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2. Interactions between antidepressants, sleep aids and selected breast cancer therapy

Author

Jody Jacobson Wedret, Thanh G. Tu, Doru Paul, Camille Rousseau, Augustin Bonta, and Robert G. Bota

Subjects
depression, insomnia, cancer patients, drugs interaction, Psychiatry, RC435-571
Abstract

Depression and insomnia are very significant pathologies in cancer patients as they contribute to the patient’s overall cure and quality of life. Moreover, untreated depression and ongoing insomnia are associated with decreased immune responses and lower survival rates. With all disease states and especially with cancer, close attention to drug-drug interactions and the potential impact on the efficacy of therapy is paramount. One area of particular interest due to the lack of well-done clinical trials is drug-drug interaction(s) between antidepressants and cancer treatment. Pharmacokinetics of a certain drug allows for prediction of certain drug interactions based on chemical properties of the agents involved. If the agents depend on their metabolites for activity, active drug level will be decreased through this enzyme inhibition. In this paper, we looked at the cytochrome-P450 drug interactions between antidepressants and sleep aids with Selective Estrogen Receptor Modulators (SERM). Newer SERM metabolisms are less influenced by interactions with medications used to treat depression. However, tamoxifen metabolism could be severely altered by several antidepressants. This has direct consequences as patients on tamoxifen and antidepressant can have double the risk of relapse to cancer in two years. We discussed those interactions and made recommendations for clinical use.

Published
2019
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3. Effect of aging treatment on apparent hydrogen solubility and trapping in a new generation maraging steel

Author

Remy Milet, Abdelali Oudriss, Xavier Feaugas, Mariem Msakni-Malouche, Camille Rousseau, Nicolas Saintier, Mohamed El May, Quentin Tonizzo, Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 (LaSIE), and Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, Hydrogen, chemistry.chemical_element, 02 engineering and technology, engineering.material, 01 natural sciences, [SPI.MAT]Engineering Sciences [physics]/Materials, Carbide, 0103 physical sciences, General Materials Science, Solubility, Spectroscopy, Maraging steel, ComputingMilieux_MISCELLANEOUS, 010302 applied physics, Austenite, Mechanical Engineering, Metallurgy, Metals and Alloys, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Microstructure, chemistry, Mechanics of Materials, engineering, 0210 nano-technology, Hydrogen embrittlement
Abstract

New generation maraging steel developed by the aeronautical industry meet the highest mechanical standards thanks to the controlled growth of M2C carbides and B2-NiAl precipitates during aging treatment at around 500 °C. However, the literature has reported a low resistance of precipitation-hardened steel to hydrogen embrittlement that is associated with aging treatment and trapping at precipitates or reverted austenite. Thus, in relation to the complex microstructure of X23NiCoCr 13-6-3 maraging steel, hydrogen solubility and trapping was investigated using Thermodesorption Spectroscopy. A high apparent solubility of hydrogen was observed after aging that was attributed to reversible trapping at coherent B2-NiAl precipitates.

Published
2020
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4. MAIT cell alterations in adults with recent-onset and long-term type 1 diabetes

Author

Christian Boitard, Léo Bertrand, Camille Rousseau, Pauline Soulard, Isabelle Nel, Etienne Larger, Agnès Lehuen, Matthieu Rouland, Lucie Beaudoin, Zouriatou Gouda, Institut Cochin, Inserm, CNRS, Laboratory of Excellence Inflamex, Université de Paris, Paris, France, Diabetology Department, Cochin Hospital, AP-HP Centre - Université de Paris, Paris, France, and ROULAND, Matthieu

Subjects
Antigens, Differentiation, T-Lymphocyte, Male, Granzyme B production, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Programmed Cell Death 1 Receptor, Blood Donors, Autoimmunity, medicine.disease_cause, 0302 clinical medicine, Glucose homeostasis, IL-2 receptor, ComputingMilieux_MISCELLANEOUS, Innate immunity, 0303 health sciences, Middle Aged, Flow Cytometry, 3. Good health, [SDV] Life Sciences [q-bio], Phenotype, Type 1 diabetes, Cytokine, Proto-Oncogene Proteins c-bcl-2, Cytokines, Female, Human, Adult, MAIT cells, Mucosal-Associated Invariant T Cells, Article, Young Adult, 03 medical and health sciences, Antigens, CD, Internal Medicine, medicine, Humans, Lectins, C-Type, Interleukin-7 receptor, Aged, 030304 developmental biology, Granzyme, Autoimmune disease, business.industry, Interleukin-2 Receptor alpha Subunit, medicine.disease, Diabetes Mellitus, Type 1, Immunology, business, Biomarkers, 030215 immunology
Abstract

Aims/hypothesis Mucosal-associated invariant T (MAIT) cells are innate-like T lymphocytes expressing an αβ T cell antigen receptor that recognises the MHC-related 1 molecule. MAIT cells are altered in children at risk for and with type 1 diabetes, and mouse model studies have shown MAIT cell involvement in type 1 diabetes development. Since several studies support heterogeneity in type 1 diabetes physiopathology according to the age of individuals, we investigated whether MAIT cells were altered in adults with type 1 diabetes. Methods MAIT cell frequency, phenotype and function were analysed by flow cytometry, using fresh peripheral blood from 21 adults with recent-onset type 1 diabetes (2–14 days after disease onset) and 47 adults with long-term disease (>2 years after diagnosis) compared with 55 healthy blood donors. We also separately analysed 17 women with long-term type 1 diabetes and an associated autoimmune disease, compared with 30 healthy women and 27 women with long-term type 1 diabetes. Results MAIT cells from adults with recent-onset type 1 diabetes, compared with healthy adult donors, harboured a strongly activated phenotype indicated by an elevated CD25+ MAIT cell frequency. In adults with long-term type 1 diabetes, MAIT cells displayed an activated and exhausted phenotype characterised by high CD25 and programmed cell death 1 (PD1) expression and a decreased production of proinflammatory cytokines, IL-2, IFN-γ and TNF-α. Even though MAIT cells from these patients showed upregulated IL-17 and IL-4 production, the polyfunctionality of MAIT cells was decreased (median 4.8 vs 13.14% of MAIT cells, p

Published
2021
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5. Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity

Author

Léo Bertrand, Antoine C. Monteiro, Jade Ghosn, Christian Boitard, Héloïse Flament, Yazdan Yazdanpanah, Agnès Lehuen, Muriel Andrieu, Karine Bailly, Xavier Lescure, Frédéric Pène, Jean-François Gautier, Diane Descamps, Benjamin Terrier, Benjamin Saintpierre, Sandrine Luce, Christophe Paget, Youenn Jouan, Camille Rousseau, Margarita Hurtado-Nedelec, Renato C. Monteiro, Mustapha Si-Tahar, Matthieu Rouland, Benoit Visseaux, Samuel Lebourgeois, Lucie Cagninacci, Lucie Beaudoin, Nadine Ajzenberg, Anaïs Vallet-Pichard, Amine Toubal, Zouriatou Gouda, Jean-François Timsit, Thomas Baranek, Pauline Soulard, Franck Letourneur, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Excellence INFLAMEX [Paris], Université Sorbonne Paris Cité (USPC), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Centre d’Etude des Pathologies Respiratoires (CEPR), UMR 1100 (CEPR), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hôpital Cochin [AP-HP], Hôpital Lariboisière-Fernand-Widal [APHP], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Gonzalez, Loïc, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), LabEx Inflamex, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, and Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, 0301 basic medicine, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Interleukin-1beta, Bronchoalveolar Lavage, Severity of Illness Index, Monocytes, Cohort Studies, 0302 clinical medicine, Chlorocebus aethiops, Macrophage, Cytotoxic T cell, Immunology and Allergy, RNA-Seq, Aged, 80 and over, Interleukin-15, Interleukin-18, Middle Aged, Interleukin-10, 3. Good health, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Cytokine, Female, France, Single-Cell Analysis, medicine.symptom, Cell activation, Adult, Immunology, Inflammation, Mucosal-Associated Invariant T Cells, Immunophenotyping, Proinflammatory cytokine, Young Adult, 03 medical and health sciences, Immune system, medicine, Animals, Humans, Vero Cells, Aged, Interleukin-6, SARS-CoV-2, business.industry, Macrophages, Monocyte, Interleukin-8, COVID-19, Interferon-alpha, 030104 developmental biology, Case-Control Studies, business, 030215 immunology
Abstract

International audience; Immune system dysfunction is paramount in coronavirus disease 2019 (COVID-19) severity and fatality rate. Mucosal-associated invariant T (MAIT) cells are innate-like T cells involved in mucosal immunity and protection against viral infections. Here, we studied the immune cell landscape, with emphasis on MAIT cells, in cohorts totaling 208 patients with various stages of disease. MAIT cell frequency is strongly reduced in blood. They display a strong activated and cytotoxic phenotype that is more pronounced in lungs. Blood MAIT cell alterations positively correlate with the activation of other innate cells, proinflammatory cytokines, notably interleukin (IL)-18, and with the severity and mortality of severe acute respiratory syndrome coronavirus 2 infection. We also identified a monocyte/macrophage interferon (IFN)-α-IL-18 cytokine shift and the ability of infected macrophages to induce the cytotoxicity of MAIT cells in an MR1-dependent manner. Together, our results suggest that altered MAIT cell functions due to IFN-α-IL-18 imbalance contribute to disease severity, and their therapeutic manipulation may prevent deleterious inflammation in COVID-19 aggravation.

Published
2021
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6. Outcome of SARS-CoV-2 infection linked to MAIT cell activation and cytotoxicity: evidence for an IL-18 dependent mechanism

Author

Renato Costa Monteiro, Christian Boitard, Maria Hurtado-Nedelec, Frédéric Pène, Héloïse Flament, Benjamin Terrier, Samuel Lebourgeois, Jean-François Timsit, Muriel Andrieu, Nadine Ajzenberg, Sandrine Luce, Jean-François Gautier, Jade Ghosn, Yazdan Yazdanpanah, Amine Toubal, Camille Rousseau, Agnès Lehuen, Diane Descamps, Léo Bertrand, Lucie Beaudoin, Karine Bailly, B Visseaux, Matthieu Rouland, Anaïs Vallet-Pichard, Pauline Soulard, Zouriatou Gouda, Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Dysfonctionnements Immunitaires [AP-HP Hôpital Bichat, Paris], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Nord Val de Seine, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Service de Virologie [CHU Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de diabétologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Département d'hépatologie [CHU Cochin], Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de diabétologie et d'endocrinologie [CHU Lariboisière], Hôpital Lariboisière-Fernand-Widal [APHP], Laboratoire d'Hématologie [Bichat], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Medical Intensive Care Unit, AP-HP, Cochin University Hospital, Paris, France., Unité de Soins Intensifs [CHU Cochin], Service de médecine interne et centre de référence des maladies rares [CHU Cochin], Unité de soins intensifs médicaux et infectieux [AP-HP Hôpital Bichat-Claude-Bernard], Lehuen, Agnès, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Hôpital Cochin [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
0303 health sciences, [SDV.IMM] Life Sciences [q-bio]/Immunology, business.industry, Mechanism (biology), Cell, Phenotype, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Immune system, 030220 oncology & carcinogenesis, Immunology, Medicine, Cytotoxic T cell, [SDV.IMM]Life Sciences [q-bio]/Immunology, Interleukin 18, business, Cell activation, Cytotoxicity, 030304 developmental biology
Abstract

Immune system dysfunction is paramount in Coronavirus disease 2019 (COVID-19) severity and fatality rate. Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells involved in mucosal immunity and protection against viral infections. Here, we studied the immune cell landscape, with emphasis on MAIT cells, in a cohort of 182 patients including patients at various stages of disease activity. A profound decrease of MAIT cell counts in blood of critically ill patients was observed. These cells showed a strongly activated and cytotoxic phenotype that positively correlated with circulating pro-inflammatory cytokines, notably IL-18. MAIT cell alterations markedly correlated with disease severity and patient mortality. SARS-CoV-2-infected macrophages activated MAIT cells in a cytokine-dependent manner involving an IFNα-dependent early phase and an IL-18-induced later phase. Therefore, altered MAIT cell phenotypes represent valuable biomarkers of disease severity and their therapeutic manipulation might prevent the inflammatory phase involved in COVID-19 aggravation.

Published
2020
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7. How does a domestication process modulate oogenesis and reproduction performance in Eurasian perch?

Author

Patrick Kestemont, Yannick Ledoré, Sandrine Viot, Pascal Fontaine, Amine Khendek, Tomas Policar, Robert Mandiki, Maud Alix, Camille Rousseau, Sylvain Milla, Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Biologie environnementale et évolutive (URBE), Département de Biologie, Université de Namur [Namur] (UNamur)-Université de Namur [Namur] (UNamur), and České Vysoké Učení Technické (CVUT)

Subjects
0106 biological sciences, media_common.quotation_subject, Population, Broodstock, Aquatic Science, 01 natural sciences, Recirculating aquaculture system, 14. Life underwater, Domestication, education, ComputingMilieux_MISCELLANEOUS, media_common, Perch, education.field_of_study, biology, Ecology, [SDV.BA]Life Sciences [q-bio]/Animal biology, 010604 marine biology & hydrobiology, 04 agricultural and veterinary sciences, biology.organism_classification, Perca fluviatilis, Gonadosomatic Index, GnRH, 040102 fisheries, 0401 agriculture, forestry, and fisheries, Vitellogenesis, Reproduction, Adaptation, Sexual steroids, Gonadotropins
Abstract

The domestication process is accompanied by adaptation of the animals to captive conditions. It induces changes at different levels thereby affecting a variety of biological functions. While there is abundant literature on the domestication effects on growth and stress response in teleosts, the effects on reproduction have received limited attention. In this work, we investigated the domestication effect on the reproductive ability of Eurasian perch (Perca fluviatilis L.), a promising candidate for the development of European aquaculture and whose reproductive physiological processes through the domestication history have not been questioned yet. To address this question, two populations of F1 and “domesticated” females were subjected to a photothermal program allowing the control of gonadogenesis advancement. Gonadosomatic index, 17β-Estradiol levels, and oocyte diameter were significantly higher in the “domesticated” population than in F1 population. In contrast, testosterone, 11-ketotestosterone, and vitellogenin levels were found to be higher in F1 females than in their “domesticated” counterparts. Lower reproductive performance was observed in the “domesticated” population compared to the F1 population in terms of embryo survival, percentage of eyed-stage larvae, hatching and percentage of malformation rates. In conclusion, this study shows that despite a positive effect on advancing gonadogenesis and vitellogenesis, this domestication route negatively affected the reproductive performance under our conditions. Statement of relevance This work will give information to producers to choose good broodstock populations (wild or domesticated) to have optimal reproductive performances in Eurasian perch, and thus improve fish production.

Published
2017
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8. Interactions between antidepressants, sleep aids and selected breast cancer therapy

Author

Doru Paul, Camille Rousseau, Robert G. Bota, Thanh G. Tu, Jody Jacobson Wedret, and Augustin Bonta

Subjects
Oncology, Drug, medicine.medical_specialty, lcsh:RC435-571, media_common.quotation_subject, insomnia, lcsh:Medicine, Disease, Review, Breast cancer, lcsh:Psychiatry, Internal medicine, medicine, media_common, drugs interaction, business.industry, lcsh:R, Cancer, medicine.disease, Clinical trial, Psychiatry and Mental health, Selective estrogen receptor modulator, depression, Antidepressant, business, cancer patients, Tamoxifen, medicine.drug
Abstract

Depression and insomnia are very significant pathologies in cancer patients as they contribute to the patient’s overall cure and quality of life. Moreover, untreated depression and ongoing insomnia are associated with decreased immune responses and lower survival rates. With all disease states and especially with cancer, close attention to drug-drug interactions and the potential impact on the efficacy of therapy is paramount. One area of particular interest due to the lack of well-done clinical trials is drug-drug interaction(s) between antidepressants and cancer treatment. Pharmacokinetics of a certain drug allows for prediction of certain drug interactions based on chemical properties of the agents involved. If the agents depend on their metabolites for activity, active drug level will be decreased through this enzyme inhibition. In this paper, we looked at the cytochrome-P450 drug interactions between antidepressants and sleep aids with Selective Estrogen Receptor Modulators (SERM). Newer SERM metabolisms are less influenced by interactions with medications used to treat depression. However, tamoxifen metabolism could be severely altered by several antidepressants. This has direct consequences as patients on tamoxifen and antidepressant can have double the risk of relapse to cancer in two years. We discussed those interactions and made recommendations for clinical use.

Published
2019

9. Effets de l’exposition maternelle aux nanoparticules d’or par ingestion, pendant la gestation, sur le développement foeto-placentaire et la fonction placentaire, dans un modèle lapin

Author

Camille Rousseau, Delphine Rousseau-Ralliard, Michèle Dahirel, Luc Jouneau, Josiane Aioun, Denis Laloë, Sylvie Huet, Lisa Meslier, Marie-Christine Aubrière, Marie Sylvie Lallemand, Guenhaël Sanz, Valerie Gelin, Catherine Archilla, Paul Fokkens, Sophie Calderari, Eugénie Canon, Olivier Dubois, Corinne Giraud-Delville, John Boere, Véronique Duranthon, Flemming Cassee, Pascale Chavatte-Palmer, Florence Jaffrezic, Valérie Fessard, Anne Couturier-Tarrade, Biologie du Développement et Reproduction (BDR), École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Université Paris Saclay (COmUE), PremUp Foundation, Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Groupe de la francophonie Placentaire (GfP). FRA., Couturier-Tarrade, Anne, École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Sorbonne Université (SU)-Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), and AgroParisTech-Institut National de la Recherche Agronomique (INRA)

Subjects
Reproductive Biology, lapin standard, [SDV.GEN]Life Sciences [q-bio]/Genetics, [SDV]Life Sciences [q-bio], Biologie du développement, Development Biology, environnement, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, développement foetal, gestation, placenta, nanoparticules, phénotype foetal, Biologie de la reproduction, [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2019

10. Effets de l’exposition maternelle aux nanoparticules d’or par ingestion pendant la gestation, sur le développement foeto-placentaire et la fonction placentaire, dans un modèle lapin

Author

Camille Rousseau, Delphine Rousseau-Ralliard, Michèle Dahirel, Christophe Richard, Luc Jouneau, Josiane Aioun, Denis Laloë, Sylvie Huet, Lila Meslier, Marie-Christine Aubrière, Marie Sylvie Lallemand, Guenhaël Sanz, Valerie Gelin, Catherine Archilla, Fokkens, Paul H., Sophie Calderari, Eugenie Canon, Olivier Dubois, Corinne Giraud-Delville, John Boere, Véronique Duranthon, Flemming Cassee, Pascale Chavatte-Palmer, Florence Jaffrezic, Valérie Fessard, Anne Couturier-Tarrade, Biologie du Développement et Reproduction (BDR), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Université Paris Saclay (COmUE), PremUp Foundation, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Descartes - Paris 5 (UPD5)-CHI Créteil-Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7), Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Fondation PremUp, Société Francophone-DOHaD. FRA., ProdInra, Migration, École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Recherche Agronomique (INRA)-AgroParisTech

Subjects
gestation, placenta, [SDV.BDD] Life Sciences [q-bio]/Development Biology, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, phénotype foetal, [SDV.BDD]Life Sciences [q-bio]/Development Biology, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology, ComputingMilieux_MISCELLANEOUS, nanoparticules
Abstract

National audience

Published
2018

11. Effects of maternal Au-NP exposure by ingestion on feto-placental development and placental function, in a rabbit model

Author

Camille Rousseau, Delphine Rousseau-Ralliard, Véronique Duranthon, Cassee, Flemming R., Pascale Chavatte-Palmer, Florence Jaffrezic, Valérie Fessard, Anne Couturier-Tarrade, Biologie du Développement et Reproduction (BDR), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Université Paris Saclay (COmUE), PremUp Foundation, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Descartes - Paris 5 (UPD5)-CHI Créteil-Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), The Nanosafety Platform-CEA.., École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Recherche Agronomique (INRA)-AgroParisTech

Subjects
[SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDV.BDD]Life Sciences [q-bio]/Development Biology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2018

12. Validity of cardiovascular prescriptions to the guidelines in the elderly according to the STOPP and START method

Author

Marie Coupet, Philippe Lozachmeur, Delphine Renvoize, Marc Fresil, Camille Rousseau, and Dominique Somme

Subjects
Male, medicine.medical_specialty, Population, Myocardial Infarction, Angiotensin-Converting Enzyme Inhibitors, Inappropriate Prescribing, Comorbidity, Acute care, Internal medicine, Atrial Fibrillation, Humans, Medicine, Myocardial infarction, education, Biological Psychiatry, Aged, Retrospective Studies, Cause of death, Aged, 80 and over, Heart Failure, education.field_of_study, business.industry, Anticoagulants, Cardiovascular Agents, Atrial fibrillation, Calcium Channel Blockers, medicine.disease, Inappropriate Prescriptions, Drug Utilization, Neuropsychology and Physiological Psychology, Cardiovascular Diseases, Heart failure, Hypertension, Cardiovascular agent, Female, France, Guideline Adherence, Neurology (clinical), Geriatrics and Gerontology, business, Constipation
Abstract

Cardiovascular diseases are the first cause of death in elderly patients. So it seems important to estimate the adequacy of the medical prescriptions to the guidelines in this population and for these diseases. A retrospective analysis was performed in nine hospitals on 736 patients aged 65 years old and over hospitalized in the acute care geriatric unit. Cardiovascular prescribing were analyzed for each patient according to STOPP and START. The population (n=736) has a mean age of 86.7 years and belongs in 45.0% of the cases to the group of dependence GIR3-4. According to STOPP, two inappropriate prescriptions are noticed: calcium channel blockers with chronic constipation concerning 9% of the included population and aspirin at dose > 150 mg/day representing 8.4% of this population. According to START, angiotensin converting enzyme inhibitor are under-prescribed in elderly patients with heart failure (140 patients = 19.0% of the population) and following acute myocardial infarction (116 patients = 15.8%). Anticoagulation in patients with atrial fibrillation is also under-prescribed: 82 patients are concerned (11.0% of the population). The prescription of ACE inhibitor is influenced by renal insufficency in patients with heart failure. The anticoagulation in atrial fibrillation is age and dependence-related. This analysis demonstrates an inadequacy between the clinical practice and guidelines for two major cardiovascular diseases: the heart failure and the atrial fibrillation. The importance of the inadequacy was suspected of opportunities for improvement, in particular in the presence of their risk factors: very elderly patients, loss of autonomy and renal insufficiency.

Published
2013
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14. Supplémenter en Vitamine D sans doser : quelles conséquences sur le taux à 2 mois ?

Author

Radet, Caroline, Université de Rennes 1 - Faculté de Médecine (UR1 Médecine), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), and Camille Rousseau

Subjects
Vitamines D -- Prescription médicale, MESH: Vitamine D -- administration et posologie, Carence en vitamines D -- Chez la personne âgée, MESH: Gériatrie, [SDV]Life Sciences [q-bio], MESH: Carence en vitamine D -- Sujet âgé, Gériatrie
Abstract

Background : Epidemiologic studies show that the prevalence of Vitamin D insufficiency in French population is 80% varying from 76% to 100% depending on studies on old people. French National Authority for Health (HAS) do not recommands a systematic control of the vitamin D concentration, before initiation of the supplementation, but we lack data on efficacy and security of this attitude. The objective of this study is to show that for people older than 65 years old hospitalised in Geriatric Unit and naive to the history of vitamin D treatment, the dosage before the supllementation is unnecessary. Design : Our hypothesis was that in this population, the recommanded level of Vitamin 25(OH)D (>30ng/ml and 30). Conclusion : Our mono-centric, and exploratory study were realised for a medicine thesis work. It confirms our hypothesis in spite of some weaknesses like a low inclusion level. In this way, patients hospitalized in Geriatric Units could obtain a level of Vitamin 25(OH)D in the recommanded norms (>30ng/ml, 30ng/ml, 30).Conclusion: Notre étude mono-centrique et réalisée de façon exploratoire dans le cadre d’une thèse de médecine confirme notre hypothèse malgré quelques faiblesses dont un taux d’inclusion un peu faible. Ainsi, en hospitalisation en Gériatrie un taux dans les normes recommandées de vitamine 25(OH)D (>30ng/ml

Published
2017

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