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Since 2016, UOW Library staff have been engaged in developing a culture of agility, strong digital literacy, and experimental exploration as part of the Future-Ready Library and the Thriving Digital Library strategies. This culture enabled the trial and implementation of a proactive chat widget at University of Wollongong Library prior to the COVID-19 pandemic. Qualitative and quantitative data show how valuable proactive chat was to the students and staff at UOW during a period of high uncertainty. Pro-active chat achieved the goal of equitable provision of resources to library users at a time when visitor and travel rules restricted physical access to UOW Library buildings and on-site staff. The pandemic has been declared over, however, UOW Library continues to utilise proactive chat and to build upon and expand its functionality. The lessons learned during the COVID-19 pandemic have shown that to withstand and succeed in the face of continued change to the provision of services in the GLAM sector, the attributes of agility and flexibility as well as strong and ongoing growth in digital literacy skills are vital. [ABSTRACT FROM AUTHOR]

The author of this article contends that the U.S. government, in conjunction with public and private sectors, are failing American society by failing the vast majority of America's urban youth. This failure is seen in America's public inner city schools where the numbers of students graduating from high school vs. the number of students dropping out of high school are, at best, one to one. A disproportionate number of these students are Black and Hispanic (Dei, G. et. al., 1997). Some studies show rates as high as 47% for Hispanics and 61% for Blacks while Hispanics make up only 13% of the U.S. population and Blacks make up 12% of the total population (Tucker, C. and Herman, K., 2002 and Hanmmack, 1986). Similar statistics are seen in the City School District of Rochester, New York, where approximately 80% of the dropouts within the City are Black and/or Hispanic (Rochester City School District; Year End Statistical Report). It becomes apparent that the social goal of educational equity for all students is not being met. In this paper, the author presents her thoughts on how to resolve these issues: (1) develop a theoretical framework that attempts to deconstruct the discourses, practices, and policies that hinder and prohibit a society from reaching its potential within an education environment; (2) explore how current practices, policies, and discourses intended to combat high attrition rates actually perpetuate and exacerbate the problem; (3) move beyond simple "band aid" solutions to explore the complexity of how power orders, maintains, and reifies social interactions; and (4) using an action research model, move towards a reflective and inclusive ideal of human potential.

Many regulatory bodies now recommend that tobacco product manufacturers provide information regarding new tobacco products' abuse liability to inform regulatory authorization of currently marketed tobacco products or new product applications (including premarket tobacco product applications in the United States). In addition, the US Food and Drug Administration (FDA) recommends including this information as part of modified risk tobacco product applications. Regulators, including FDA, and many public health officials and researchers consider abuse liability assessment a model which predicts the likelihood that the use of the tobacco product would result in addiction and be used repeatedly or even sporadically resulting in undesirable effects. Abuse liability of a new, potentially reduced harm product can also inform its ability to substitute completely for more harmful tobacco products. While many methods exist, no standard tobacco product abuse liability assessment has been established. The purpose of this review is to provide background information and practical recommendations for human abuse liability testing methods to meet tobacco regulatory needs. A combination of nicotine test product pharmacokinetic, subjective effect and/or behavioral response, and physiological response data relative to comparator products with known abuse liability satisfies some regulatory requirements. Implications: This review provides a practical inspection of the current, international regulatory recommendations for abuse liability assessment of tobacco and regulatory review of such information within the United States and also recommends study designs and methods for abuse liability testing of tobacco products based on scientific and regulatory knowledge. Given that tobacco product abuse liability testing is of increasing interest to regulatory bodies globally, especially with the emergence of novel tobacco products, this timely work provides background and functional recommendations for tobacco product abuse liability testing. [ABSTRACT FROM AUTHOR]

Summary: In seeds and other parts of cultivated, tetraploid cotton (Gossypium hirsutum L.), multicellular groups of cells lysigenously form dark glands containing toxic terpenoids such as gossypol that defend the plant against pests and pathogens. Using RNA‐seq analysis of embryos from near‐isogenic glanded (Gl2Gl2Gl3Gl3) versus glandless (gl2gl2gl3gl3) plants, we identified 33 genes that expressed exclusively or at higher levels in embryos just prior to gland formation in glanded plants. Virus‐induced gene silencing against three gene pairs led to significant reductions in the number of glands in the leaves, and significantly lower levels of gossypol and related terpenoids. These genes encode transcription factors and have been designated the 'Cotton Gland Formation' (CGF) genes. No sequence differences were found between glanded and glandless cotton for CGF1 and CGF2 gene pairs. The glandless cotton has a transposon insertion within the coding sequence of the GoPGF (synonym CGF3) gene of the A subgenome and extensive mutations in the promoter of D subgenome homeolog. Overexpression of GoPGF (synonym CGF3) led to a dramatic increase in gossypol and related terpenoids in cultured cells, whereas CRISPR/Cas9 knockout of GoPGF (synonym CGF3) genes resulted in glandless phenotype. Taken collectively, the results show that the GoPGF (synonym CGF3) gene plays a critical role in the formation of glands in the cotton plant. Seed‐specific silencing of CGF genes, either individually or in combination, could eliminate glands, thus gossypol, from the cottonseed to render it safe as food or feed for monogastrics. [ABSTRACT FROM AUTHOR]