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GenoML is a Python package automating machine learning workflows for genomics (genetics and multi-omics) with an open science philosophy. Genomics data require significant domain expertise to clean, pre-process, harmonize and perform quality control of the data. Furthermore, tuning, validation, and interpretation involve taking into account the biology and possibly the limitations of the underlying data collection, protocols, and technology. GenoML's mission is to bring machine learning for genomics and clinical data to non-experts by developing an easy-to-use tool that automates the full development, evaluation, and deployment process. Emphasis is put on open science to make workflows easily accessible, replicable, and transferable within the scientific community. Source code and documentation is available at https://genoml.com.

Model-free reinforcement learning (RL) can be used to learn effective policies for complex tasks, such as Atari games, even from image observations. However, this typically requires very large amounts of interaction -- substantially more, in fact, than a human would need to learn the same games. How can people learn so quickly? Part of the answer may be that people can learn how the game works and predict which actions will lead to desirable outcomes. In this paper, we explore how video prediction models can similarly enable agents to solve Atari games with fewer interactions than model-free methods. We describe Simulated Policy Learning (SimPLe), a complete model-based deep RL algorithm based on video prediction models and present a comparison of several model architectures, including a novel architecture that yields the best results in our setting. Our experiments evaluate SimPLe on a range of Atari games in low data regime of 100k interactions between the agent and the environment, which corresponds to two hours of real-time play. In most games SimPLe outperforms state-of-the-art model-free algorithms, in some games by over an order of magnitude.

Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression rate, impairment of memory and cognitive abilities. Due to these variabilities, personalized care and treatment planning, as well as patient counseling about their individual progression is limited. Recent developments in machine learning to detect hidden patterns in complex, multi-dimensional datasets provides significant opportunities to address this critical need. In this work, we use unsupervised and supervised machine learning approaches for subtype identification and prediction. We apply machine learning methods to the extensive clinical observations available at the Alzheimer's Disease Neuroimaging Initiative (ADNI) data set to identify patient subtypes and to predict disease progression. Our analysis depicts the progression space for the Alzheimer's disease into low, moderate and high disease progression zones. The proposed work will enable early detection and characterization of distinct disease subtypes based on clinical heterogeneity. We anticipate that our models will enable patient counseling, clinical trial design, and ultimately individualized clinical care., Comment: This volume represents the accepted submissions from the Machine Learning for Health (ML4H) workshop at the conference on Neural Information Processing Systems (NeurIPS) 2018, held on December 8, 2018 in Montreal, Canada

State-of-the-art deep learning systems rely on iterative distributed training to tackle the increasing complexity of models and input data. The iteration time in these communication-heavy systems depends on the computation time, communication time and the extent of overlap of computation and communication. In this work, we identify a shortcoming in systems with graph representation for computation, such as TensorFlow and PyTorch, that result in high variance in iteration time --- random order of received parameters across workers. We develop a system, TicTac, to improve the iteration time by fixing this issue in distributed deep learning with Parameter Servers while guaranteeing near-optimal overlap of communication and computation. TicTac identifies and enforces an order of network transfers which improves the iteration time using prioritization. Our system is implemented over TensorFlow and requires no changes to the model or developer inputs. TicTac improves the throughput by up to $37.7\%$ in inference and $19.2\%$ in training, while also reducing straggler effect by up to $2.3\times$. Our code is publicly available.

Predicting the future in real-world settings, particularly from raw sensory observations such as images, is exceptionally challenging. Real-world events can be stochastic and unpredictable, and the high dimensionality and complexity of natural images requires the predictive model to build an intricate understanding of the natural world. Many existing methods tackle this problem by making simplifying assumptions about the environment. One common assumption is that the outcome is deterministic and there is only one plausible future. This can lead to low-quality predictions in real-world settings with stochastic dynamics. In this paper, we develop a stochastic variational video prediction (SV2P) method that predicts a different possible future for each sample of its latent variables. To the best of our knowledge, our model is the first to provide effective stochastic multi-frame prediction for real-world video. We demonstrate the capability of the proposed method in predicting detailed future frames of videos on multiple real-world datasets, both action-free and action-conditioned. We find that our proposed method produces substantially improved video predictions when compared to the same model without stochasticity, and to other stochastic video prediction methods. Our SV2P implementation will be open sourced upon publication.

We present a mechanism that puts users in the center of control and empowers them to dictate the access to their collections of data. Revisiting the fundamental mechanisms in security for providing protection, our solution uses capabilities, access lists, and access rights following well-understood formal notions for reasoning about access. This contribution presents a practical, correct, auditable, transparent, distributed, and decentralized mechanism that is well-matched to the current emerging environments including Internet of Things, smart city, precision medicine, and autonomous cars. It is based on well-tested principles and practices used in a distributed authorization, cryptocurrencies, and scalable computing.

In an effort to overcome the data deluge in computational biology and bioinformatics and to facilitate bioinformatics research in the era of big data, we identify some of the most influential algorithms that have been widely used in the bioinformatics community. These top data mining and machine learning algorithms cover classification, clustering, regression, graphical model-based learning, and dimensionality reduction. The goal of this study is to guide the focus of scalable computing experts in the endeavor of applying new storage and scalable computation designs to bioinformatics algorithms that merit their attention most, following the engineering maxim of "optimize the common case".

While there exist many isolation mechanisms that are available to cloud service providers, including virtual machines, containers, etc., the problem of side-channel increases in importance as a remaining security vulnerability, particularly in the presence of shared caches and multicore processors. In this paper we present a hardware-software mechanism that improves the isolation of cloud processes in the presence of shared caches on multicore chips. Combining the Intel CAT architecture that enables cache partitioning on the fly with novel scheduling techniques and state cleansing mechanisms, we enable cache-side-channel free computing for Linux-based containers and virtual machines, in particular, those managed by KVM. We do a preliminary evaluation of our system using a CPU bound workload. Our system allows Simultaneous Multithreading (SMT) to remain enabled and does not require application level changes.

Convolutional autoregressive models have recently demonstrated state-of-the-art performance on a number of generation tasks. While fast, parallel training methods have been crucial for their success, generation is typically implemented in a na\"{i}ve fashion where redundant computations are unnecessarily repeated. This results in slow generation, making such models infeasible for production environments. In this work, we describe a method to speed up generation in convolutional autoregressive models. The key idea is to cache hidden states to avoid redundant computation. We apply our fast generation method to the Wavenet and PixelCNN++ models and achieve up to $21\times$ and $183\times$ speedups respectively., Comment: Accepted at ICLR 2017 Workshop

During the past decade, machine learning has become extremely popular and can be found in many aspects of our every day life. Nowayadays with explosion of data while rapid growth of computation capacity, Distributed Deep Neural Networks (DDNNs) which can improve their performance linearly with more computation resources, have become hot and trending. However, there has not been an in depth study of the performance of these systems, and how well they scale. In this paper we analyze CNTK, one of the most commonly used DDNNs, by first building a performance model and then evaluating the system two settings: a small cluster with all nodes in a single rack connected to a top of rack switch, and in large scale using Blue Waters with arbitary placement of nodes. Our main focus was the scalability of the system with respect to adding more nodes. Based on our results, this system has an excessive initialization overhead because of poor I/O utilization which dominates the whole execution time. Because of this, the system does not scale beyond a few nodes (4 in Blue Waters). Additionally, due to a single server-multiple worker design the server becomes a bottleneck after 16 nodes limiting the scalability of the CNTK.

Neural networks are usually over-parameterized with significant redundancy in the number of required neurons which results in unnecessary computation and memory usage at inference time. One common approach to address this issue is to prune these big networks by removing extra neurons and parameters while maintaining the accuracy. In this paper, we propose NoiseOut, a fully automated pruning algorithm based on the correlation between activations of neurons in the hidden layers. We prove that adding additional output neurons with entirely random targets results into a higher correlation between neurons which makes pruning by NoiseOut even more efficient. Finally, we test our method on various networks and datasets. These experiments exhibit high pruning rates while maintaining the accuracy of the original network.

Application-level peer-to-peer (P2P) network overlays are an emerging paradigm that facilitates decentralization and flexibility in the scalable deployment of applications such as group communication, content delivery, and data sharing. However the construction of the overlay graph topology optimized for low latency, low link and node stress and lookup performance is still an open problem. We present a design of an overlay constructed on top of a social network and show that it gives a sizable improvement in lookups, average round-trip delay and scalability as opposed to other overlay topologies. We build our overlay on top of the topology of a popular real-world social network namely Orkut. We show Orkuts suitability for our purposes by evaluating the clustering behavior of its graph structure and the socializing pattern of its members., Comment: 9 pages 8 figures