2,224 results on '"Campbell, Stuart"'
Search Results
2. Radiation-induced changes in gene expression in rectal cancer specimens
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Hillson, Lily Victoria Sarah, McCulloch, Ashley Kathryn, Edwards, Joanne, Dunne, Philip David, O’Cathail, Sean Michael, and Roxburgh, Campbell Stuart
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- 2024
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3. What is missing in autonomous discovery: Open challenges for the community
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Maffettone, Phillip M., Friederich, Pascal, Baird, Sterling G., Blaiszik, Ben, Brown, Keith A., Campbell, Stuart I., Cohen, Orion A., Collins, Tantum, Davis, Rebecca L., Foster, Ian T., Haghmoradi, Navid, Hereld, Mark, Jung, Nicole, Kwon, Ha-Kyung, Pizzuto, Gabriella, Rintamaki, Jacob, Steinmann, Casper, Torresi, Luca, and Sun, Shijing
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Condensed Matter - Materials Science - Abstract
Self-driving labs (SDLs) leverage combinations of artificial intelligence, automation, and advanced computing to accelerate scientific discovery. The promise of this field has given rise to a rich community of passionate scientists, engineers, and social scientists, as evidenced by the development of the Acceleration Consortium and recent Accelerate Conference. Despite its strengths, this rapidly developing field presents numerous opportunities for growth, challenges to overcome, and potential risks of which to remain aware. This community perspective builds on a discourse instantiated during the first Accelerate Conference, and looks to the future of self-driving labs with a tempered optimism. Incorporating input from academia, government, and industry, we briefly describe the current status of self-driving labs, then turn our attention to barriers, opportunities, and a vision for what is possible. Our field is delivering solutions in technology and infrastructure, artificial intelligence and knowledge generation, and education and workforce development. In the spirit of community, we intend for this work to foster discussion and drive best practices as our field grows.
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- 2023
4. Self-driving Multimodal Studies at User Facilities
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Maffettone, Phillip M., Allan, Daniel B., Campbell, Stuart I., Carbone, Matthew R., Caswell, Thomas A., DeCost, Brian L., Gavrilov, Dmitri, Hanwell, Marcus D., Joress, Howie, Lynch, Joshua, Ravel, Bruce, Wilkins, Stuart B., Wlodek, Jakub, and Olds, Daniel
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Condensed Matter - Materials Science ,Computer Science - Human-Computer Interaction - Abstract
Multimodal characterization is commonly required for understanding materials. User facilities possess the infrastructure to perform these measurements, albeit in serial over days to months. In this paper, we describe a unified multimodal measurement of a single sample library at distant instruments, driven by a concert of distributed agents that use analysis from each modality to inform the direction of the other in real time. Powered by the Bluesky project at the National Synchrotron Light Source II, this experiment is a world's first for beamline science, and provides a blueprint for future approaches to multimodal and multifidelity experiments at user facilities., Comment: 36th Conference on Neural Information Processing Systems (NeurIPS 2022). AI4Mat Workshop
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- 2023
5. ACCOUNTING FOR CHANGE?
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Campbell, Stuart, primary
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- 2023
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6. Signaling network model of cardiomyocyte morphological changes in familial cardiomyopathy.
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Khalilimeybodi, Ali, Riaz, Muhammad, Campbell, Stuart, Qyang, Yibing, Saucerman, Jeffrey, McCulloch, Andrew, and Omens, Jeffrey
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Cardiac growth ,DCM ,Familial cardiomyopathy ,Genotype to phenotype ,HCM ,Inherited cardiomyopathy ,Patient-specific iPSC-CMs ,Signaling ,Animals ,Mice ,Connectin ,Myocytes ,Cardiac ,Cardiomyopathy ,Hypertrophic ,Calcium ,Phosphatidylinositol 3-Kinases ,Proto-Oncogene Proteins c-akt ,Cardiomyopathies ,Heart Failure - Abstract
Familial cardiomyopathy is a precursor of heart failure and sudden cardiac death. Over the past several decades, researchers have discovered numerous gene mutations primarily in sarcomeric and cytoskeletal proteins causing two different disease phenotypes: hypertrophic (HCM) and dilated (DCM) cardiomyopathies. However, molecular mechanisms linking genotype to phenotype remain unclear. Here, we employ a systems approach by integrating experimental findings from preclinical studies (e.g., murine data) into a cohesive signaling network to scrutinize genotype to phenotype mechanisms. We developed an HCM/DCM signaling network model utilizing a logic-based differential equations approach and evaluated model performance in predicting experimental data from four contexts (HCM, DCM, pressure overload, and volume overload). The model has an overall prediction accuracy of 83.8%, with higher accuracy in the HCM context (90%) than DCM (75%). Global sensitivity analysis identifies key signaling reactions, with calcium-mediated myofilament force development and calcium-calmodulin kinase signaling ranking the highest. A structural revision analysis indicates potential missing interactions that primarily control calcium regulatory proteins, increasing model prediction accuracy. Combination pharmacotherapy analysis suggests that downregulation of signaling components such as calcium, titin and its associated proteins, growth factor receptors, ERK1/2, and PI3K-AKT could inhibit myocyte growth in HCM. In experiments with patient-specific iPSC-derived cardiomyocytes (MLP-W4R;MYH7-R723C iPSC-CMs), combined inhibition of ERK1/2 and PI3K-AKT rescued the HCM phenotype, as predicted by the model. In DCM, PI3K-AKT-NFAT downregulation combined with upregulation of Ras/ERK1/2 or titin or Gq protein could ameliorate cardiomyocyte morphology. The model results suggest that HCM mutations that increase active force through elevated calcium sensitivity could increase ERK activity and decrease eccentricity through parallel growth factors, Gq-mediated, and titin pathways. Moreover, the model simulated the influence of existing medications on cardiac growth in HCM and DCM contexts. This HCM/DCM signaling model demonstrates utility in investigating genotype to phenotype mechanisms in familial cardiomyopathy.
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- 2023
7. MLExchange: A web-based platform enabling exchangeable machine learning workflows for scientific studies
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Zhao, Zhuowen, Chavez, Tanny, Holman, Elizabeth A., Hao, Guanhua, Green, Adam, Krishnan, Harinarayan, McReynolds, Dylan, Pandolfi, Ronald, Roberts, Eric J., Zwart, Petrus H., Yanxon, Howard, Schwarz, Nicholas, Sankaranarayanan, Subramanian, Kalinin, Sergei V., Mehta, Apurva, Campbell, Stuart, and Hexemer, Alexander
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
Machine learning (ML) algorithms are showing a growing trend in helping the scientific communities across different disciplines and institutions to address large and diverse data problems. However, many available ML tools are programmatically demanding and computationally costly. The MLExchange project aims to build a collaborative platform equipped with enabling tools that allow scientists and facility users who do not have a profound ML background to use ML and computational resources in scientific discovery. At the high level, we are targeting a full user experience where managing and exchanging ML algorithms, workflows, and data are readily available through web applications. Since each component is an independent container, the whole platform or its individual service(s) can be easily deployed at servers of different scales, ranging from a personal device (laptop, smart phone, etc.) to high performance clusters (HPC) accessed (simultaneously) by many users. Thus, MLExchange renders flexible using scenarios -- users could either access the services and resources from a remote server or run the whole platform or its individual service(s) within their local network., Comment: The accepted version with DOI and IEEE copyright notice in the first page
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- 2022
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8. Bronchiectasis among Australian Aboriginal and non-Aboriginal patients in the regional and remote population of the Northern Territory of Australia
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Mehra, Sumit, Chang, Anne B, Lam, Chor K, Campbell, Stuart, Mingi, Joy J, Thomas, Izaak, Harwood, Suzanne, Maguire, Graeme, and Heraganahally, Subash
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- 2021
9. Rational engineering of lung alveolar epithelium
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Leiby, Katherine L., Yuan, Yifan, Ng, Ronald, Raredon, Micha Sam Brickman, Adams, Taylor S., Baevova, Pavlina, Greaney, Allison M., Hirschi, Karen K., Campbell, Stuart G., Kaminski, Naftali, Herzog, Erica L., and Niklason, Laura E.
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- 2023
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10. Artificial Intelligence Driven Experiments at User Facilities
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Maffettone, Phillip M., primary, Allan, Daniel B., additional, Barbour, Andi, additional, Caswell, Thomas A., additional, Gavrilov, Dmitri, additional, Hanwell, Marcus D., additional, Morris, Thomas, additional, Olds, Daniel, additional, Rakitin, Max, additional, Campbell, Stuart I., additional, and Ravel, Bruce, additional
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- 2023
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11. Machine learning enabling high-throughput and remote operations at large-scale user facilities
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Konstantinova, Tatiana, Maffettone, Phillip M., Ravel, Bruce, Campbell, Stuart I., Barbour, Andi M., and Olds, Daniel
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Computer Science - Machine Learning ,Physics - Applied Physics - Abstract
Imaging, scattering, and spectroscopy are fundamental in understanding and discovering new functional materials. Contemporary innovations in automation and experimental techniques have led to these measurements being performed much faster and with higher resolution, thus producing vast amounts of data for analysis. These innovations are particularly pronounced at user facilities and synchrotron light sources. Machine learning (ML) methods are regularly developed to process and interpret large datasets in real-time with measurements. However, there remain conceptual barriers to entry for the facility general user community, whom often lack expertise in ML, and technical barriers for deploying ML models. Herein, we demonstrate a variety of archetypal ML models for on-the-fly analysis at multiple beamlines at the National Synchrotron Light Source II (NSLS-II). We describe these examples instructively, with a focus on integrating the models into existing experimental workflows, such that the reader can easily include their own ML techniques into experiments at NSLS-II or facilities with a common infrastructure. The framework presented here shows how with little effort, diverse ML models operate in conjunction with feedback loops via integration into the existing Bluesky Suite for experimental orchestration and data management., Comment: 12 pages, 5 figures
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- 2022
12. GSK-3β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation
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Stachowski-Doll, Marisa J, Papadaki, Maria, Martin, Thomas G, Ma, Weikang, Gong, Henry M, Shao, Stephanie, Shen, Shi, Muntu, Nitha Aima, Kumar, Mohit, Perez, Edith, Martin, Jody L, Moravec, Christine S, Sadayappan, Sakthivel, Campbell, Stuart G, Irving, Thomas, and Kirk, Jonathan A
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Medical Physiology ,Biomedical and Clinical Sciences ,Heart Disease ,Cardiovascular ,Aetiology ,Underpinning research ,2.1 Biological and endogenous factors ,1.1 Normal biological development and functioning ,Animals ,Connectin ,Glycogen Synthase Kinase 3 beta ,Heart Failure ,Humans ,Mice ,Mice ,Knockout ,Myocytes ,Cardiac ,Phosphorylation ,Rats ,calcium ,cardiac myocytes ,connectin ,mice ,myofibrils ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
BackgroundAltered kinase localization is gaining appreciation as a mechanism of cardiovascular disease. Previous work suggests GSK-3β (glycogen synthase kinase 3β) localizes to and regulates contractile function of the myofilament. We aimed to discover GSK-3β's in vivo role in regulating myofilament function, the mechanisms involved, and the translational relevance.MethodsInducible cardiomyocyte-specific GSK-3β knockout mice and left ventricular myocardium from nonfailing and failing human hearts were studied.ResultsSkinned cardiomyocytes from knockout mice failed to exhibit calcium sensitization with stretch indicating a loss of length-dependent activation (LDA), the mechanism underlying the Frank-Starling Law. Titin acts as a length sensor for LDA, and knockout mice had decreased titin stiffness compared with control mice, explaining the lack of LDA. Knockout mice exhibited no changes in titin isoforms, titin phosphorylation, or other thin filament phosphorylation sites known to affect passive tension or LDA. Mass spectrometry identified several z-disc proteins as myofilament phospho-substrates of GSK-3β. Agreeing with the localization of its targets, GSK-3β that is phosphorylated at Y216 binds to the z-disc. We showed pY216 was necessary and sufficient for z-disc binding using adenoviruses for wild-type, Y216F, and Y216E GSK-3β in neonatal rat ventricular cardiomyocytes. One of GSK-3β's z-disc targets, abLIM-1 (actin-binding LIM protein 1), binds to the z-disc domains of titin that are important for maintaining passive tension. Genetic knockdown of abLIM-1 via siRNA in human engineered heart tissues resulted in enhancement of LDA, indicating abLIM-1 may act as a negative regulator that is modulated by GSK-3β. Last, GSK-3β myofilament localization was reduced in left ventricular myocardium from failing human hearts, which correlated with depressed LDA.ConclusionsWe identified a novel mechanism by which GSK-3β localizes to the myofilament to modulate LDA. Importantly, z-disc GSK-3β levels were reduced in patients with heart failure, indicating z-disc localized GSK-3β is a possible therapeutic target to restore the Frank-Starling mechanism in patients with heart failure.
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- 2022
13. On the colour tuning and stability of carbene-metal-amide organic light-emitting diodes
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Matthews, Campbell Stuart Baldwin, Credgington, Dan, and Greenham, Neil
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carbene-metal-amide ,CMA ,OLED ,organic light-emitting diode - Abstract
This thesis focusses on the development of a family of light emitting molecules and their incorporation into organic light emitting diodes (OLEDs). OLEDs are currently widely utilised in consumer display products. Blue OLEDs, however, are unable to simultaneous meet the industrial requirements of colour purity, efficiency and device lifetime. Most consumer products choose to compromise on efficiency and hence most commercial blue OLEDs are relatively inefficient compared to their red and green counterparts. The need for an efficient and stable blue emitter is clear and requires investigations into new classes of emitters. One such possibility are carbene-metal-amides (CMAs). CMAs are a family of charge transfer type photoemitters which luminescence through a thermally activated delayed fluorescence mechanism. CMAs have been previously incorporated into highly efficient green OLEDs. In chapter 4, CMAs are first chemically modified through the addition of electron donating and withdrawing groups on the carbazole. The modifications achieve a predictable spectral shift in the luminescence, which can be further tuned by the use of host polarity. Efficient deep blue CMA OLEDs are demonstrated but suffer from exceptionally poor device lifetime. In chapter 5, attempts are made to improve the device lifetime. The CMAs are first chemically modified to improve stability to electro chemical oxidation. Although stability improvements are observed in the cyclic voltammetry, there is no correlating improvement in device lifetime. The CMA material is also purified to try and reduce impurity induced degradation. Again no improvement in device lifetime is achieved. In Chapter 6, an investigation is made into the intrinsic mechanism which drives degradation in CMA OLEDs. Bimolecular exciton-exciton interactions are identified as the primary degradation pathway. Attempts are made to minimise this interaction and lead to some improvement. Ultimately, however, the device lifetime of CMA OLEDs remains extremely short. Future work must find a way to substantially improve the stability of CMAs and may lead to the development of a similar, but new class of emitters.
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- 2022
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14. Modifying Candidacy and Management to Improve Extracorporeal Support During Supply-Demand Mismatch
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Tham, Elwin, Amoateng, Emmanuel, Campbell, Stuart, Sappington, Penny, McCarthy, Paul, and Hayanga, J.W. Awori
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- 2024
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15. TTN truncation variants produce sarcomere-integrating proteins of uncertain functional significance
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Hinson, J. Travis and Campbell, Stuart G.
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Cardiomyopathy, Dilated -- Genetic aspects -- Development and progression ,Muscle proteins -- Physiological aspects -- Genetic aspects ,Genetic variation -- Physiological aspects -- Health aspects ,Muscle cells -- Physiological aspects -- Health aspects ,Health care industry - Abstract
Titin (TTN) is one of the largest and most complex proteins expressed in humans, and truncation variants are the most prevalent genetic lesion identified in individuals with dilated cardiomyopathy (DCM) or other disorders of impaired cardiac contractility. Two reports in this issue of the JCI shed light on a potential mechanism involving truncated TTN sarcomere integration and the potential for disruption of sarcomere structural integrity. Kellermayer, Tordai, and colleagues confirmed the presence of truncated TTN protein in human DCM samples. McAfee and authors developed a patient-specific TTN antibody to study truncated TTN subcellular localization and to explore its functional consequences. A 'poison peptide' mechanism emerges that inspires alternative therapeutic approaches while opening new lines for inquiry, such as the role of haploinsufficiency of full- length TTN protein, mechanisms explaining sarcomere dysfunction, and explanations for variable penetrance., TTN structure and function The sarcomere is the fundamental contractile unit of the myocyte and is commonly subdivided into Z-disc, I-band, A-band, and M-line regions, and the titin (TTN) protein [...]
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- 2024
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16. Ovarian cancer symptoms in pre-clinical invasive epithelial ovarian cancer – An exploratory analysis nested within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
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Dilley, James, Gentry-Maharaj, Aleksandra, Ryan, Andy, Burnell, Matthew, Manchanda, Ranjit, Kalsi, Jatinderpal, Singh, Naveena, Woolas, Robert, Sharma, Aarti, Williamson, Karin, Mould, Tim, Fallowfield, Lesley, Campbell, Stuart, Skates, Steven J., McGuire, Alistair, Parmar, Mahesh, Jacobs, Ian, and Menon, Usha
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- 2023
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17. Inequalities in Student to Course Match: Evidence from Linked Administrative Data. CEP Discussion Paper No. 1647
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London School of Economics and Political Science (United Kingdom), Centre for Economic Performance (CEP), Campbell, Stuart, Macmillan, Lindsey, Murphy, Richard, and Wyness, Gill
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This paper examines inequalities in the match between student quality and university quality using linked administrative data from schools, universities and tax authorities. We analyse two measures of match at the university-subject (course) level, based on student academic attainment, and graduate earnings. We find that students from lower socio-economic groups systematically undermatch for both measures across the distribution of attainment, with particularly stark socio-economic gaps for the most undermatched. While there are negligible gender gaps in academic match, high-attaining women systematically undermatch in terms of expected earnings, largely driven by subject choice.
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- 2019
18. Tumour stage, treatment, and survival of women with high-grade serous tubo-ovarian cancer in UKCTOCS: an exploratory analysis of a randomised controlled trial
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Menon, Usha, Gentry-Maharaj, Aleksandra, Burnell, Matthew, Ryan, Andy, Singh, Naveena, Manchanda, Ranjit, Kalsi, Jatinderpal K, Woolas, Robert, Arora, Rupali, Casey, Laura, Dawnay, Anne, Sharma, Aarti, Williamson, Karin, Apostolidou, Sophia, Fallowfield, Lesley, McGuire, Alistair J, Campbell, Stuart, Skates, Steven J, Jacobs, Ian J, and Parmar, Mahesh K B
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- 2023
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19. Clinical presentation and outcomes following infection with Vibrio spp., Aeromonas spp., Chromobacterium violaceum and Shewanella spp. (VACS) water-associated organisms in tropical Australia, 2015-2022
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Campbell, Stuart, primary, MacGregor, Kirsten, additional, Smith, Emma L, additional, Kanitkar, Tanmay, additional, Janson, Sonja, additional, Baird, Robert W, additional, Currie, Bart J, additional, and Venkatesan, Sudharsan, additional
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- 2024
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20. Abstract 17931: Auxotonic MyoPod® Engineered Heart Tissues Enable Longitudinal Tracking of in vitro Development of Hypertrophic Cardiomyopathy
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Rupert, Cassady, Archer, Benjamin, Dau, Viet, Cirilli, Shannon, li, xia, and Campbell, Stuart G
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- 2023
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21. Catalyzing sustainable fisheries management through behavior change interventions
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McDonald, Gavin, Wilson, Molly, Veríssimo, Diogo, Twohey, Rebecca, Clemence, Michaela, Apistar, Dean, Box, Stephen, Butler, Paul, Cadiz, Fel Cesar, Campbell, Stuart J, Cox, Courtney, Effron, Micah, Gaines, Steve, Jakub, Raymond, Mancao, Roquelito H, Rojas, Pablo T, Tirona, Rocky Sanchez, and Vianna, Gabriel
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Environmental Sciences ,Environmental Management ,Behavioral and Social Science ,Life Below Water ,Animals ,Brazil ,Conservation of Natural Resources ,Fisheries ,Fishes ,Indonesia ,Philippines ,behavior change campaigns ,fisheries management ,impact evaluation ,monitoring and evaluation ,perceptions data ,small-scale fisheries ,social marketing ,TURF reserve ,TURF 保护区 ,behavior change campaigns ,fisheries management ,impact evaluation ,monitoring and evaluation ,perceptions data ,campañas de cambio de comportamiento ,datos de percepción ,evaluación de impacto ,manejo de pesquerías ,mercadotecnia social ,monitoreo y evaluación ,pesquerías a pequeña escala ,reserva TURF ,social marketing ,TURF reserve ,小型渔业 ,影响评估 ,渔业管理 ,监测和评估 ,社会营销 ,行为改变活动 ,认知数据 ,Biological Sciences ,Agricultural and Veterinary Sciences ,Ecology ,Zoology ,Environmental management - Abstract
Small-scale fisheries are an important livelihood and primary protein source for coastal communities in many of the poorest regions in the world, yet many are overfished and thus require effective and scalable management solutions. Positive ecological and socioeconomic responses to management typically lag behind immediate costs borne by fishers from fishing pressure reductions necessary for fisheries recovery. These short-term costs challenge the long-term success of these interventions. However, social marketing may increase perceptions of management benefits before ecological and socioeconomic benefits are fully realized, driving new social norms and ultimately long-term sustainable behavior change. By conducting underwater visual surveys to quantify ecological conditions and by conducting household surveys with community members to quantify their perceptions of management support and socioeconomic conditions, we assessed the impact of a standardized small-scale fisheries management intervention that was implemented across 41 sites in Brazil, Indonesia, and the Philippines. The intervention combines TURF reserves (community-based territorial use rights for fishing coupled with no-take marine reserves) with locally tailored social-marketing behavior change campaigns. Leveraging data across 22 indicators and 4 survey types, along with data from 3 control sites, we found that ecological and socioeconomic impacts varied and that communities supported the intervention and were already changing their fishing practices. These results suggest that communities were developing new social norms and fishing more sustainably before long-term ecological and socioeconomic benefits of fisheries management materialized.
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- 2020
22. Insights from UKCTOCS for design, conduct and analyses of large randomised controlled trials
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Menon Usha, Gentry-Maharaj Aleksandra, Burnell Matthew, Apostolidou Sophia, Ryan Andy, Kalsi Jatinderpal K, Singh Naveena, Fallowfield Lesley, McGuire Alistair J, Campbell Stuart, Skates Steven J, Dawnay Anne, Parmar Mahesh, and Jacobs Ian J
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screening ,randomised controlled trial ,conduct ,design ,ovarian cancer ,Medical technology ,R855-855.5 - Abstract
Randomised controlled trials are challenging to deliver. There is a constant need to review and refine recruitment and implementation strategies if they are to be completed on time and within budget. We present the strategies adopted in the United Kingdom Collaborative Trial of Ovarian Cancer Screening, one of the largest individually randomised controlled trials in the world. The trial recruited over 202,000 women (2001–5) and delivered over 670,000 annual screens (2001–11) and over 3 million women-years of follow-up (2001–20). Key to the successful completion were the involvement of senior investigators in the day-to-day running of the trial, proactive trial management and willingness to innovate and use technology. Our underlying ethos was that trial participants should always be at the centre of all our processes. We ensured that they were able to contact either the site or the coordinating centre teams for clarifications about their results, for follow-up and for rescheduling of appointments. To facilitate this, we shared personal identifiers (with consent) with both teams and had dedicated reception staff at both site and coordinating centre. Key aspects were a comprehensive online trial management system which included an electronic data capture system (resulting in an almost paperless trial), biobanking, monitoring and project management modules. The automation of algorithms (to ascertain eligibility and classify results and ensuing actions) and processes (scheduling of appointments, printing of letters, etc.) ensured the protocol was closely followed and timelines were met. Significant engagement with participants ensured retention and low rates of complaints. Our solutions to the design, conduct and analyses issues we faced are highly relevant, given the renewed focus on trials for early detection of cancer. Future work There is a pressing need to increase the evidence base to support decision making about all aspects of trial methodology. Trial registration ISRCTN-22488978; ClinicalTrials.gov-NCT00058032. Funding This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number 16/46/01. The long-term follow-up UKCTOCS (2015 20) was supported by National Institute for Health and Care Research (NIHR HTA grant 16/46/01), Cancer Research UK, and The Eve Appeal. UKCTOCS (2001–14) was funded by the MRC (G9901012 and G0801228), Cancer Research UK (C1479/A2884), and the UK Department of Health, with additional support from The Eve Appeal. Researchers at UCL were supported by the NIHR UCL Hospitals Biomedical Research Centre and by the MRC Clinical Trials Unit at UCL core funding (MC_UU_00004/09, MC_UU_00004/08, MC_UU_00004/07). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the UK Department of Health and Social Care. Plain language summary Randomised controlled trials help us decide whether new health-care approaches are better than those in current use. To successfully complete these on time and within budget, there is a constant need to review and revise the procedures used for delivering various aspects such as invitation, enrolment, follow-up of participants, delivery of the new test, data collection, and analysis. We report on the processes used in the United Kingdom Collaborative Trial of Ovarian Cancer Screening, one of the largest such trials. The United Kingdom Collaborative Trial of Ovarian Cancer Screening enrolled over 202,000 women (2001–5), delivered over 670,000 yearly screens (2001–11) and followed all participants until 2020. Key to our successful completion were the involvement of senior investigators in day-to-day running of the trial, a pre-emptive approach to issues, a willingness to innovate, and the use of technology. Our underlying ethos was that trial participants should always be at the centre of all our processes. We ensured that they were able to always contact either their local or the central team for clarifications and rescheduling of appointments. To facilitate this, we shared participant contact details (with consent) with both teams. We built a comprehensive electronic system to manage all aspects of the trial. This included online forms that the teams completed in real time (resulting in an almost paperless trial) and systems to check and manage trial processes and track blood samples. We automated key steps such as checking whether participants were eligible, assigning correct action based on results of screening tests, scheduling appointments and printing letters. As a result, all participants were treated as set out in the trial plan. Our engagement with participants ensured that they continued participating and we had a low rate of complaints. We faced issues with regard to our initial trial design and the way we planned to analyse the data. We feel that our solutions are highly relevant, especially as there is a renewed focus on trials for early detection of cancer.
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- 2023
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23. Adaptive time-stepping for Stochastic Partial Differential Equations with non-Lipschitz drift
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Campbell, Stuart and Lord, Gabriel
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Mathematics - Numerical Analysis ,(Primary) 65C30, 60H15, 65N12 - Abstract
We introduce an explicit, adaptive time-stepping scheme for the simulation of SPDEs with one-sided Lipschitz drift coefficients. Strong convergence rates are proven for the full space-time discretisation with multiplicative trace-class noise by considering the space and time discretisation separately. Adapting the time-step size to ensure strong convergence is shown numerically to produce more accurate solutions when compared to alternative fixed time-stepping strategies for the same computational effort., Comment: 32 pages, 4 figures
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- 2018
24. The relationship between body mass index and mortality is not linear in patients requiring venovenous extracorporeal support
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Tham, Elwin, Campbell, Stuart, Hayanga, Heather, Ammons, Jeffrey, Fang, Wei, Sappington, Penny, McCarthy, Paul, Toker, Alper, Badhwar, Vinay, and Hayanga, J.W. Awori
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- 2023
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25. Mortality impact, risks, and benefits of general population screening for ovarian cancer: the UKCTOCS randomised controlled trial
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Menon Usha, Gentry-Maharaj Aleksandra, Burnell Matthew, Ryan Andy, Kalsi Jatinderpal K, Singh Naveena, Dawnay Anne, Fallowfield Lesley, McGuire Alistair J, Campbell Stuart, Skates Steven J, Parmar Mahesh, and Jacobs Ian J
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ovarian cancer ,ovarian epithelial carcinoma ,ovarian neoplasms ,cancer screening ,early detection of cancer ,ukctocs ,randomised controlled trial ,rct ,ca-125 antigen ,transvaginal ultrasound ,ultrasonography ,general population ,Medical technology ,R855-855.5 - Abstract
Background Ovarian and tubal cancers are lethal gynaecological cancers, with over 50% of the patients diagnosed at advanced stage. Trial design Randomised controlled trial involving 27 primary care trusts adjacent to 13 trial centres based at NHS Trusts in England, Wales and Northern Ireland. Methods Participants Postmenopausal average-risk women, aged 50–74, with intact ovaries and no previous ovarian or current non-ovarian cancer. Interventions One of two annual screening strategies: (1) multimodal screening (MMS) using a longitudinal CA125 algorithm with repeat CA125 testing and transvaginal scan (TVS) as second line test (2) ultrasound screening (USS) using TVS alone with repeat scan to confirm any abnormality. The control (C) group had no screening. Follow-up was through linkage to national registries, postal follow-up questionnaires and direct communication with trial centres and participants. Objective To assess comprehensively risks and benefits of ovarian cancer screening in the general population. Outcome Primary outcome was death due to ovarian or tubal cancer as assigned by an independent outcomes review committee. Secondary outcomes included incidence and stage at diagnosis of ovarian and tubal cancer, compliance, performance characteristics, harms and cost-effectiveness of the two screening strategies and a bioresource for future research. Randomisation The trial management system confirmed eligibility and randomly allocated participants using computer-generated random numbers to MMS, USS and C groups in a 1:1:2 ratio. Blinding Investigators and participants were unblinded and outcomes review committee was masked to randomisation group. Analyses Primary analyses were by intention to screen, comparing separately MMS and USS with C using the Versatile test. Results Recruitment 1,243,282 women were invited and 205,090 attended for recruitment between April 2001 and September 2005. Randomised 202,638 women: 50,640 MMS, 50,639 USS and 101,359 C group. Numbers analysed for primary outcome 202,562 (>99.9%): 50,625 (>99.9%) MMS, 50,623 (>99.9%) USS, and 101,314 (>99.9%) C group. Outcome Women in MMS and USS groups underwent 345,570 and 327,775 annual screens between randomisation and 31 December 2011. At median follow-up of 16.3 (IQR 15.1–17.3) years, 2055 women developed ovarian or tubal cancer: 522 (1.0% of 50,625) MMS, 517 (1.0% of 50,623) USS, and 1016 (1.0% of 101314) in C group. Compared to the C group, in the MMS group, the incidence of Stage I/II disease was 39.2% (95% CI 16.1 to 66.9) higher and stage III/IV 10.2% (95% CI –21.3 to 2.4) lower. There was no difference in stage in the USS group. 1206 women died of the disease: 296 (0.6%) MMS, 291 (0.6%) USS, and 619 (0.6%) C group. There was no significant reduction in ovarian and tubal cancer deaths in either MMS (p = 0.580) or USS (p = 0.360) groups compared to the C group. Overall compliance with annual screening episode was 80.8% (345,570/420,047) in the MMS and 78.0% (327,775/420,047) in the USS group. For ovarian and tubal cancers diagnosed within one year of the last test in a screening episode, in the MMS group, the sensitivity, specificity and positive predictive values were 83.8% (95% CI 78.7 to 88.1), 99.8% (95% CI 99.8 to 99.9), and 28.8% (95% CI 25.5 to 32.2) and in the USS group, 72.2% (95% CI 65.9 to 78.0), 99.5% (95% CI 99.5 to 99.5), and 9.1% (95% CI 7.8 to 10.5) respectively. The final within-trial cost-effectiveness analysis was not undertaken as there was no mortality reduction. A bioresource (UKCTOCS Longitudinal Women’s Cohort) of longitudinal outcome data and over 0.5 million serum samples including serial annual samples in women in the MMS group was established and to date has been used in many new studies, mainly focused on early detection of cancer. Harms Both screening tests (venepuncture and TVS) were associated with minor complications with low (8.6/100,000 screens MMS; 18.6/100,000 screens USS) complication rates. Screening itself did not cause anxiety unless more intense repeat testing was required following abnormal screens. In the MMS group, for each screen-detected ovarian or tubal cancer, an additional 2.3 (489 false positives; 212 cancers) women in the MMS group had unnecessary false-positive (benign adnexal pathology or normal adnexa) surgery. Overall, 14 (489/345,572 annual screens) underwent unnecessary surgery per 10,000 screens. In the USS group, for each screen-detected ovarian or tubal cancer, an additional 10 (1630 false positives; 164 cancers) underwent unnecessary false-positive surgery. Overall, 50 (1630/327,775 annual screens) women underwent unnecessary surgery per 10,000 screens. Conclusions Population screening for ovarian and tubal cancer for average-risk women using these strategies should not be undertaken. Decreased incidence of Stage III/IV cancers during multimodal screening did not translate to mortality reduction. Researchers should be cautious about using early stage as a surrogate outcome in screening trials. Meanwhile the bioresource provides a unique opportunity to evaluate early cancer detection tests. Funding Long-term follow-up UKCTOCS (2015–2020) – National Institute for Health and Care Research (NIHR HTA grant 16/46/01), Cancer Research UK, and The Eve Appeal. UKCTOCS (2001–2014) – Medical Research Council (MRC) (G9901012/G0801228), Cancer Research UK (C1479/A2884), and the UK Department of Health, with additional support from The Eve Appeal. Researchers at UCL were supported by the NIHR UCL Hospitals Biomedical Research Centre and by MRC Clinical Trials Unit at UCL core funding (MR_UU_12023). Plain language summary What was the question? Most women with ovarian cancer are diagnosed after the disease has spread widely (advanced stage – III and IV) and more than half die within 5 years. We wanted to find out if testing women without symptoms could pick up ovarian cancer at an earlier stage before it has spread beyond the ovaries and tubes and reduce deaths. We also wanted to assess the risks and benefits of such screening. What did we do? We invited over 1.2 million women living near 13 centres in England, Wales and Northern Ireland. Of them, 202,638 joined the trial. All women were between 50 and 74 and were no longer having periods. They had never been diagnosed with ovarian cancer or were not having treatment for any other cancer. They did not have many relatives with ovarian or breast cancer. The volunteers were placed into one of three groups at random: The blood test group contained 50,640 women who had yearly CA125 blood tests. If these showed a moderate or high chance of ovarian cancer, they had repeat CA125 tests and a scan. The scan group contained 50,639 women who had yearly internal scans of their ovaries and tubes which were repeated if they showed an abnormality. The no-screening group contained 101,359 women. Those in the blood and scan groups had screening every year until December 2011. We sent all women health questionnaires and also, with their permission, received information about them from the national cancer and death registries till mid-2020. What did we find? Women in the screened groups had an average of eight years of screening. We followed them for approximately 16 years after they had joined the trial. During this period, 2055 women were diagnosed with ovarian and tubal cancer. It was about 1 in 100 women (1%) in all three groups: 522 of 50,625 in the blood group 517 of 50,623 in the scan group 1016 of 101,314 in the no-screening group More women were diagnosed with early-stage cancer and fewer were diagnosed with advanced cancer in the blood group compared to the no-screening group. There was no difference in the number diagnosed with early or advanced disease between the scan and no-screening group. Despite this difference, the number of women in each group who died from ovarian and tubal cancer was similar in all three groups: 296 of 50,625 (0.6%) in the blood group, 291 of 50,623 (0.6%) in the scan group and 619 of 101,314 (0.6%) in the no-screening group. Other results showed: Overall, 81% women in the blood group and 78% in the scan group attended all of their annual screening appointments. In the blood group, screening detected 84% of ovarian and tubal cancers diagnosed within one year of the test and correctly classified as normal 99.8% of women who did not have ovarian and tubal cancer. In the scan group, screening detected 72% of ovarian and tubal cancers diagnosed within one year of the last test and correctly classified 99.5% of those who did not have ovarian and tubal cancer. Both screening tests were associated with minor complications. While screening did not increase anxiety, there was slightly increased worry in women who were asked to return for more intense repeat testing. Both screening methods picked up changes that were in fact not ovarian cancer. This meant that women had unnecessary surgery together with the worry and risk of complications that go with it. ◦In the blood group 14 women had unnecessary surgery for every 10,000 women screened annually. This means that for each woman found to have ovarian cancer, an additional 2 women had unnecessary surgery. ◦In the scan group 50 women had unnecessary surgery for every 10,000 women screened annually. This means that for each woman found to have ovarian cancer, an additional 10 women had unnecessary surgery. A biobank with all the donated data and over 0.5 million serum samples, including yearly samples from women in the blood group, was built and continues to be used in many new studies, mainly focused on early detection of cancer. What does this mean? Screening using the CA125 blood test or transvaginal ultrasound scan to test for ovarian cancer did not save lives. Additionally, it was associated with some harm. Therefore, an ovarian cancer screening programme for most women cannot be currently recommended. The trial also showed for the first time that ovarian cancer can be detected earlier through screening. However, for screening to save lives, the test needs to pick up many more women earlier in the course of the disease so that available treatments are effective. The biobank provides an opportunity for scientists to see if newer tests for cancer can detect the disease earlier.
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- 2023
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26. Innovation in plant and soil sciences to tackle critical global challenges
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Field, Katie J., primary, Carrillo, Yolima, additional, Campbell, Stuart A., additional, Ton, Jurriaan, additional, and Frew, Adam, additional
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- 2024
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27. High-Performance Multi-Mode Ptychography Reconstruction on Distributed GPUs
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Dong, Zhihua, Fang, Yao-Lung L., Huang, Xiaojing, Yan, Hanfei, Ha, Sungsoo, Xu, Wei, Chu, Yong S., Campbell, Stuart I., and Lin, Meifeng
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Physics - Computational Physics ,Condensed Matter - Mesoscale and Nanoscale Physics ,Computer Science - Distributed, Parallel, and Cluster Computing ,Physics - Optics - Abstract
Ptychography is an emerging imaging technique that is able to provide wavelength-limited spatial resolution from specimen with extended lateral dimensions. As a scanning microscopy method, a typical two-dimensional image requires a number of data frames. As a diffraction-based imaging technique, the real-space image has to be recovered through iterative reconstruction algorithms. Due to these two inherent aspects, a ptychographic reconstruction is generally a computation-intensive and time-consuming process, which limits the throughput of this method. We report an accelerated version of the multi-mode difference map algorithm for ptychography reconstruction using multiple distributed GPUs. This approach leverages available scientific computing packages in Python, including mpi4py and PyCUDA, with the core computation functions implemented in CUDA C. We find that interestingly even with MPI collective communications, the weak scaling in the number of GPU nodes can still remain nearly constant. Most importantly, for realistic diffraction measurements, we observe a speedup ranging from a factor of $10$ to $10^3$ depending on the data size, which reduces the reconstruction time remarkably from hours to typically about 1 minute and is thus critical for real-time data processing and visualization., Comment: work presented in NYSDS 2018
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- 2018
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28. Delivering real-time multi-modal materials analysis with enterprise beamlines
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Maffettone, Phillip M., Campbell, Stuart, Hanwell, Marcus D., Wilkins, Stuart, and Olds, Daniel
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- 2022
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29. Household finances and trust are key determinants of benefits from small-scale fisheries co-management
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Kushardanto, Hari, Jakub, Raymond, Suherfian, Wahid, Subarno, Tarlan, Ansyori, Ahmad Isa, Sara, La, Alimina, Naslina, Fajriah, Kardini, La Ode, de la Rosa, Emilio, Yuliani, Ade, Medianti, Eva, Pradana, Imanda, Setiawan, Haris, Muhammad, Yoni, Djafar, Lely Fajriah, Box, Stephen, Cox, Courtney, and Campbell, Stuart J.
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- 2022
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30. Benefits of measurable population connectivity metrics for area-based marine management
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Krueck, Nils C., Tong, Colm, Cox, Courtney, Treml, Eric A., Critchell, Kay, Chollett, Iliana, Adhuri, Dedi S., Beger, Maria, Muenzel, Dominic, Holstein, Daniel, Campbell, Stuart J., and Jakub, Raymond
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- 2022
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31. The mirror, the magus and more: reflections on John Dee's obsidian mirror
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Campbell, Stuart, Healey, Elizabeth, Kuzmin, Yaroslav, and Glascock, Michael D.
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Anthropology/archeology/folklore ,British Museum - Abstract
The obsidian mirror associated with the Elizabethan polymath and magus John Dee (1527-1608/1609) has been an object of fascination for centuries. The mirror, however, has a deeper history as an Aztec artefact brought to Europe soon after the Spanish conquest. The authors present the results of new geochemical analysis, and explore its history and changing cultural context to provide insights into its meaning during a period in which entirely new world views were emerging. The biography of the mirror demonstrates how a complex cultural history underpins an iconic object. The study highlights the value of new compositional analyses of museum objects for the reinterpretation of historically significant material culture. Keywords: Mesoamerica, Aztec, John Dee, obsidian, XRF, mirrors, Introduction One of the most well-known objects on display in the British Museum's Enlightenment Gallery is the obsidian mirror associated with John Dee, the Renaissance polymath, magus and confidant of [...]
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- 2021
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32. Marine conservation in the Sunda Banda Seascape, Indonesia
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Estradivari, Andradi-Brown, Dominic A., Amkieltiela, Handayani, Christian N., Sjahruddin, Fikri F., Agung, Muh. Firdaus, Campbell, Stuart J., Claborn, Kelly, De Nardo, Matheus, Fox, Helen E., Glew, Louise, Hakim, Amehr, Lazuardi, Muhammad Erdi, Nanlohy, Hellen, Sanjaya, Wira, Setyawan, Edy, Timisela, Natelda R., Veverka, Laura, Wiwardhana, Nara Wisesa, Welly, Marthen, Zainudin, Imam Musthofa, and Ahmadia, Gabby N.
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- 2022
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33. Marine conservation beyond MPAs: Towards the recognition of other effective area-based conservation measures (OECMs) in Indonesia
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Estradivari, Agung, Muh. Firdaus, Adhuri, Dedi Supriadi, Ferse, Sebastian C.A., Sualia, Ita, Andradi-Brown, Dominic A., Campbell, Stuart J., Iqbal, Mohamad, Jonas, Harry D., Lazuardi, Muhammad Erdi, Nanlohy, Hellen, Pakiding, Fitryanti, Pusparini, Ni Kadek Sri, Ramadhana, Hikmah C., Ruchimat, Toni, Santiadji, I Wayan Veda, Timisela, Natelda R., Veverka, Laura, and Ahmadia, Gabby N.
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- 2022
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34. Mild Approaches in Ovarian Stimulation
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Datta, Adrija Kumar, primary, Campbell, Stuart, additional, and Nargund, Geeta, additional
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- 2022
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35. Energy potential of the Ecca Group from the southern Main Karoo Basin, South Africa
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Campbell, Stuart Alexander
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553.2 ,G Geography (General) - Abstract
Energy shortages and sporadic, controlled blackouts have been a defining feature of South Africa’s aging national energy grid for more than a decade. To investigate local energy sources from shale gas, two boreholes were drilled in the southern Main Karoo Basin into the Permian-aged Ecca Group by the Karoo Research Initiative. Borehole KZF-1 (Western Cape) intersected thick shale successions of the lower Ecca Group and revealed the stratigraphic duplication of the Whitehill (shale gas target) and Prince Albert Formations. This structural deformation was most likely as a result of the organic-rich formations, acting as a decollement for thrust faults related to the north-south directed compression of the Cape Orogeny. Reservoir compartmentalisation and gas escape along porous fault zones hinder hydrocarbon exploration in the area. Borehole KWV-1 (Eastern Cape) revealed thick successions of turbiditic sandstones and a moderately elevated geothermal gradient. The clastic rocks have low permeabilities and high thermal conductivities. Analysis of the petro- and thermophysical data from the Ripon Formation sandstones, from both the core and nearby Ecca Pass outcrop location, show the potential of the formation as an Enhanced Geothermal Reservoir, with temperatures exceeding 100°C being suitable for energy production from a binary geothermal power plant. The comparison of combined gamma-ray logs, geothermal potential of samples (specific heat capacity, thermal diffusivity, and thermal conductivity) and lithological logs show a correlation between lithological composition and geothermal reservoir potential that can be identified in gamma-ray log patterns. These correlations can be extrapolated for purposes of geothermal exploration in non-cored nearby boreholes. The numerous pre-existing faults, decreasing from the basin’s southern margin towards the basin interior, elevate the risk of inducing seismic events from the use of reservoir stimulation techniques associated with energy exploration, as well as wastewater management associated with future extraction activities.
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- 2018
36. Myofilament glycation in diabetes reduces contractility by inhibiting tropomyosin movement, is rescued by cMyBPC domains
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Papadaki, Maria, Kampaengsri, Theerachat, Barrick, Samantha K., Campbell, Stuart G., von Lewinski, Dirk, Rainer, Peter P., Harris, Samantha P., Greenberg, Michael J., and Kirk, Jonathan A.
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- 2022
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37. Xi-cam: a versatile interface for data visualization and analysis.
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Pandolfi, Ronald J, Allan, Daniel B, Arenholz, Elke, Barroso-Luque, Luis, Campbell, Stuart I, Caswell, Thomas A, Blair, Austin, De Carlo, Francesco, Fackler, Sean, Fournier, Amanda P, Freychet, Guillaume, Fukuto, Masafumi, Gürsoy, Dogˇa, Jiang, Zhang, Krishnan, Harinarayan, Kumar, Dinesh, Kline, R Joseph, Li, Ruipeng, Liman, Christopher, Marchesini, Stefano, Mehta, Apurva, N'Diaye, Alpha T, Parkinson, Dilworth Y, Parks, Holden, Pellouchoud, Lenson A, Perciano, Talita, Ren, Fang, Sahoo, Shreya, Strzalka, Joseph, Sunday, Daniel, Tassone, Christopher J, Ushizima, Daniela, Venkatakrishnan, Singanallur, Yager, Kevin G, Zwart, Peter, Sethian, James A, and Hexemer, Alexander
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GISAXS ,GIWAXS ,NEXAFS ,SAXS ,WAXS ,XAS ,scattering ,software ,spectroscopy ,tomography ,GISAX ,Biophysics ,Condensed Matter Physics ,Optical Physics ,Physical Chemistry (incl. Structural) - Abstract
Xi-cam is an extensible platform for data management, analysis and visualization. Xi-cam aims to provide a flexible and extensible approach to synchrotron data treatment as a solution to rising demands for high-volume/high-throughput processing pipelines. The core of Xi-cam is an extensible plugin-based graphical user interface platform which provides users with an interactive interface to processing algorithms. Plugins are available for SAXS/WAXS/GISAXS/GIWAXS, tomography and NEXAFS data. With Xi-cam's `advanced' mode, data processing steps are designed as a graph-based workflow, which can be executed live, locally or remotely. Remote execution utilizes high-performance computing or de-localized resources, allowing for the effective reduction of high-throughput data. Xi-cam's plugin-based architecture targets cross-facility and cross-technique collaborative development, in support of multi-modal analysis. Xi-cam is open-source and cross-platform, and available for download on GitHub.
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- 2018
38. Legislation and Persuasion; Portable Antiquities and the Limits of the Law: Some Scottish and British Perspectives
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Campbell, Stuart, Campbell, Stuart, editor, White, Liz, editor, and Thomas, Suzie, editor
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- 2019
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39. Introduction
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White, Liz, Campbell, Stuart, Thomas, Suzie, Campbell, Stuart, editor, White, Liz, editor, and Thomas, Suzie, editor
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- 2019
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40. Hypocalcemic Crisis: Acute Postoperative and Long-Term Management of Hypocalcemia
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Campbell, Stuart, primary, Corrigan, Tara, additional, Bilezikian, John P., additional, and Shifrin, Alexander, additional
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- 2022
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41. CONTRIBUTORS
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Ahmadi, Sara, primary, Akula, Monika S., additional, Alexander, Erik K., additional, Angell, Trevor E., additional, Anderson, Maureen McCartney, additional, Bilezikian, John P., additional, Bornstein, Stefan Richard, additional, Calissendorff, Jan, additional, Campbell, Stuart, additional, Chukir, Tariq, additional, Corrigan, Tara, additional, Falhammar, Henrik, additional, Farooki, Azeez, additional, Flippo, Chelsi, additional, Frasier, Lane L., additional, Gemma, Vincent, additional, Girotra, Monica, additional, Goel, Ansha, additional, Goodier, Christopher G., additional, Guzman, Heidi, additional, Ishii, Makoto, additional, Ito, Yasuhiro, additional, Kazim, Michael, additional, Keating, Jane J., additional, Kotwal, Anupam, additional, Krasnova, Svetlana L., additional, Lam, David W., additional, Lechner, Melissa G., additional, Loftley, Aundrea Eason, additional, Lubitz, Sara E., additional, Mandel, Louis, additional, Masuoka, Hiroo, additional, Mestman, Jorge H., additional, Miyauchi, Akira, additional, Nguyen, Caroline T., additional, Ong, Raquel Kristin Sanchez, additional, Owen, Randall P., additional, Pommier, Rodney F., additional, Prescott, Jason D., additional, Punati, Ramya, additional, Romero-Velez, Gustavo, additional, Schneider, Arthur B., additional, Seitz, Alison P., additional, Shifrin, Alexander L., additional, Shiroff, Adam Michael, additional, Stan, Marius N., additional, Stratakis, Constantine A., additional, Tatsi, Christina, additional, Toft, Daniel J., additional, Topilow, Arthur, additional, Tran, Ann Q., additional, Verbalis, Joseph G., additional, Wartofsky, Leonard, additional, Wonn, Sarah M., additional, Ylli, Dorina, additional, and Young, William F., additional
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- 2022
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42. Preseason weight-bearing ankle dorsiflexion in male professional football players with and without a history of severe ankle injury: A novel analysis in an English Premier League club
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Clark, Nicholas C. and Campbell, Stuart D.
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- 2021
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43. Estimating the Ovarian Cancer CA-125 Preclinical Detectable Phase, In-Vivo Tumour Doubling Time, and Window for Detection in Early Stage: An Exploratory Analysis of UKCTOCS
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Bedia, Jacob S., primary, Jacobs, Ian J., additional, Ryan, Andy, additional, Gentry-Maharaj, Aleksandra, additional, Burnell, Matthew, additional, Manchanda, Ranjit, additional, Kalsi, Jatinderpal K., additional, Dawnay, Anne, additional, Fallowfield, Lesley, additional, McGuire, Alistair, additional, Campbell, Stuart, additional, Parmar, Mahesh KB, additional, Menon, Usha, additional, and Skates, Steven J., additional
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- 2024
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44. A Data-Driven Approach to Understanding Customer Satisfaction
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Barzizza, Elena, primary, Campbell, Stuart, additional, Ceccato, Riccardo, additional, Dobosz, Anna, additional, Haag, Marco, additional, Martins, Rafaella, additional, and Salmaso, Luigi, additional
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- 2024
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45. Classifying pathogenicity of TPM1 variants of unknown significance using in vitro and in silico approaches
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Campbell, Stuart, primary, Creso, Jenette, additional, Firlar, Ilayda, additional, Halder, Saiti, additional, Lehman, William, additional, Rynkiewicz, Michael, additional, and Moore, Jeffrey, additional
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- 2024
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46. MicroRNA function can be reversed by altering target gene expression levels
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Svoronos, Alexander A., Campbell, Stuart G., and Engelman, Donald M.
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- 2021
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47. Evidence for synergy between sarcomeres and fibroblasts in an in vitro model of myocardial reverse remodeling
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Shen, Shi, Sewanan, Lorenzo R., and Campbell, Stuart G.
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- 2021
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48. Enabling Scientific Discovery at Next-Generation Light Sources with Advanced AI and HPC
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Schwarz, Nicholas, Campbell, Stuart, Hexemer, Alexander, Mehta, Apurva, Thayer, Jana, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Nichols, Jeffrey, editor, Verastegui, Becky, editor, Maccabe, Arthur ‘Barney’, editor, Hernandez, Oscar, editor, Parete-Koon, Suzanne, editor, and Ahearn, Theresa, editor
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- 2020
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49. Biodiversity needs every tool in the box: use OECMs
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Gurney, Georgina G., Darling, Emily S., Ahmadia, Gabby N., Agostini, Vera N., Ban, Natalie C., Blythe, Jessica, Claudet, Joachim, Epstein, Graham, Cornell-Himes, Amber, Jonas, Harry D., Armitage, Derek, Campbell, Stuart J., Cox, Courtney, Friedman, Whitney R., Gill, David, Lestari, Peni, and Mangubhai, Sangeeta
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Nature conservation -- Methods ,Wilderness areas -- Identification and classification ,Biological diversity -- Environmental aspects ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
To conserve global biodiversity, countries must forge equitable alliances that support sustainability in traditional pastoral lands, fisheries-management areas, Indigenous territories and more. To conserve global biodiversity, countries must forge equitable alliances that support sustainability in traditional pastoral lands, fisheries-management areas, Indigenous territories and more., Author(s): Georgina G. Gurney, Emily S. Darling, Gabby N. Ahmadia, Vera N. Agostini, Natalie C. Ban, Jessica Blythe, Joachim Claudet, Graham Epstein, Estradivari, Amber Himes-Cornell, Harry D. Jonas, Derek Armitage, [...]
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- 2021
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50. Proteomic analysis of archaeological ceramics from Tell Khaiber, southern Iraq
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Chowdhury, Manasij Pal, Campbell, Stuart, and Buckley, Michael
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- 2021
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