Search

Your search keyword '"Campieri, C"' showing total 128 results
Start Over Author "Campieri, C"
128 results on '"Campieri, C"'

5. Risk for chronic kidney disease in the general population italian reports for the the world kiney days 2007-2009

Author

Galassi, A, Brancaccio, D, Andreucci, Ve, Andreucci, M, Caglioti, A, Faga, T, Mazzitello, G, Antonelli, A, Carlini, A, Giusti, R, Rosati, A, Apperti, V, Auricchio, Mr, Avella, F, Barbato, A, Romano, P, Barzaghi, B, Bedani, Pl, Bellinghieri, G, Costantino, G, Bernardi, A, Bolasco, P, Ferrara, R, Pani, A, Bonomini, M, Busnach, G, Conte, F, Limido, A, Messa, Pg, Sinico, Ra, Spotti, D, Cadinu, F, Campieri, C, Capuano, M, Terribile, M, Cardone, F, Paglia, S, Castellino, P, Di Landro, D, Fatuzzo, P, Liuzzo, G, Sicurezza, E, Casu, Md, Centrone, E, Ciofani, A, Cossu, M, D'Amaro, E, D'Apice, L, Dal Canton, A, Fasoli, G, De Ferrari, G, Cappelli, Gianni, Gusmano, R, De Simone, W, Delgado, G, Di Iorio, B, Di Luca, M, Di Natale, E, Farfaglia, P, Cantú, P, Feriozzi, S, Galeotti, P, Fiorini, F, Frascà, Gm, Gallucci, M, Buongiorno, E, Gesualdo, L, Giannattasio, M, Detomaso, F, Giannetto, M, Gianni, S, Giliberti, A, Grassi, C, Lupi, Gp, Imperiali, P, Juliano, P, Li Vecchi, M, Lucenti, T, Maffucci, G, Anelli, Am, Manno, M, Schena, Fp, Mazzaferro, S, Migliorati, M, Morrone, L, Mura, M, Petrarulo, F, Pizzarelli, F, Ricciardi, B, Riccobene, G, Rondanini, V, Russo, D, Sasdelli, M, Mura, C, Scarpino, L, Selvi, S, Tarchini, R, Tedesco, A, Timio, F, Traversari, L, Venditti, G, Viganò, S, Locatelli, F., Galassi, A., Andreucci, M, Caglioti, A., Faga, T., Mazzitello, G., Antonelli, A., Carlini, A., Giusti, R., Rosati, A., Apperti, V., Auricchio, M. R., Avella, F., Barbato, A., Romano, P., Barzaghi, B., Bedani, P. L., Bellinghieri, G., Costantino, G., Bernardi, A., Bolasco, P., Ferrara, R., Pani, A., Bonomini, M., Brancaccio, D., Busnach, G., Conte, F., Limido, A., Messa, P. G., Sinico, R. A., Spotti, D., Cadinu, F., Campieri, C., Capuano, M., Terribile, M., Cardone, F., Paglia, S., Castellino, P., Di Landro, D., Fatuzzo, P., Liuzzo, G., Sicurezza, E., Casu, M. D., Centrone, E., Ciofani, A., Cossu, M., D'Amaro, E., D'Apice, L., Dal Canton, A., Fasoli, G., De Ferrari, G., Cappelli, G., Gusmano, R., De Simone, W., Delgado, G., Di Iorio, B., Di Luca, M., Di Natale, E., Farfaglia, P., Cantù, P., Feriozzi, S., Galeotti, P., Fiorini, F., Frascà, G. M., Gallucci, M., Buongiorno, E., Gesualdo, L., Giannattasio, M., Detomaso, F., Giannetto, M., Gianni, S., Giliberti, A., Grassi, C., Lupi, G. P., Imperiali, P., Juliano, P., Li Vecchi, M., Lucenti, T., Maffucci, G., Anelli, A. M., Manno, M., Schena, F. P., Mazzaferro, S., Migliorati, M., Morrone, L., Mura, M., Petrarulo, F., Pizzarelli, F., Ricciardi, B., Riccobene, G., Rondanini, V., Russo, Domenico, Sasdelli, M., Mura, C., Scarpino, L., Selvi, S., Tarchini, R., Tedesco, A., Timio, M., Traversari, L., Venditti, G., Viganò, S., Locatelli, F., Galassi, A, Caglioti, A, Faga, T, Mazzitello, G, Antonelli, A, Carlini, A, Giusti, R, Rosati, A, Apperti, V, Auricchio, M, Avella, F, Barbato, A, Romano, P, Barzaghi, B, Bedani, P, Bellinghieri, G, Costantino, G, Bernardi, A, Bolasco, P, Ferrara, R, Pani, A, Bonomini, M, Brancaccio, D, Busnach, G, Conte, F, Limido, A, Messa, P, Sinico, R, Spotti, D, Cadinu, F, Campieri, C, Capuano, M, Terribile, M, Cardone, F, Paglia, S, Castellino, P, Di Landro, D, Fatuzzo, P, Liuzzo, G, Sicurezza, E, Casu, M, Centrone, E, Ciofani, A, Cossu, M, D'Amaro, E, D'Apice, L, Dal Canton, A, Fasoli, G, De Ferrari, G, Cappelli, G, Gusmano, R, De Simone, W, Delgado, G, Di Iorio, B, Di Luca, M, Di Natale, E, Farfaglia, P, Cantù, P, Feriozzi, S, Galeotti, P, Fiorini, F, Frascà, G, Gallucci, M, Buongiorno, E, Gesualdo, L, Giannattasio, M, Detomaso, F, Giannetto, M, Gianni, S, Giliberti, A, Grassi, C, Lupi, G, Imperiali, P, Juliano, P, Li Vecchi, M, Lucenti, T, Maffucci, G, Anelli, A, Manno, M, Schena, F, Mazzaferro, S, Migliorati, M, Morrone, L, Mura, M, Petrarulo, F, Pizzarelli, F, Ricciardi, B, Riccobene, G, Rondanini, V, Russo, D, Sasdelli, M, Mura, C, Scarpino, L, Selvi, S, Tarchini, R, Tedesco, A, Timio, M, Traversari, L, Venditti, G, Viganò, S, and Locatelli, F

Subjects
Proteinuria, Time Factors, Italy, Risk Factors, Nephrology, Chronic Disease, Diabetic Nephropathies/etiology, Hypertension, Humans, Diabetic Nephropathies, Kidney Diseases
Published
2010

8. La Prevenzione in Nefrologia

Author

Andreucci, Ve, Amendola, G, Andreucci, M, Auricchio, Mr, Avella, F, Bedani, Pl, Bellinghieri, G, Bernardi, Am, Bonomini, M, Brancaccio, D, Buoncristiani, U, Buzio, C, Cadinu, F, Caglioti, A, Campieri, C, Capuano, M, Carlini, A, Castellino, Pietro, Casu, Md, Cavatorta, F, Ciofani, A, Cossu, M, Cozzolino, M, D'Apice, L, DE SIMONE, W, DEL PRETE, M, DI IORIO BR, Faga, T, Frascà, G, Fuiano, G, Galassi, A, Gallucci, M, Gesualdo, L, Giannattasio, M, Gianni, S, Giliberti, A, Grassi, C, Iuliano, P, LI VECCHI, M, Lusenti, T, Marrocco, A, Mazzaferro, S, Mazzitello, G, Migliorati, M, Morrone, L, Pallotta, G, Petrarulo, F, Pizzarelli, F, Ricciardi, B, Rondanini, V, Russo, D, Sasdelli, M, Scarpino, L, Selvi, A, Tarchini, R, Tedesco, A, Timio, M, and Vernaglione, L.

Published
2008

13. HIV prevalence in dialysis patients in Italy

Author

Ippolito G, Petrosillo N, Puro V, Arici C, Cesare S, Berardi MP, Campieri C, Daglio M, Della Volpe M, Di Legge R, Maggi P, Ippolito, G, Petrosillo, N, Puro, V, Arici, C, Cesare, S, Berardi, Mp, Campieri, C, Daglio, M, Della Volpe, M, Di Legge, R, and Maggi, P

Published
1992

15. Risk for chronic kidney disease in the general population: Italian reports for World Kidney Days 2007-2009

Author

Galassi, A, Andreucci, M, Caglioti, A, Faga, T, Mazzitello, G, Antonelli, A, Carlini, A, Giusti, R, Rosati, A, Apperti, V, Auricchio, M, Avella, F, Barbato, A, Romano, P, Barzaghi, B, Bedani, P, Bellinghieri, G, Costantino, G, Bernardi, A, Bolasco, P, Ferrara, R, Pani, A, Bonomini, M, Brancaccio, D, Busnach, G, Conte, F, Limido, A, Messa, P, Sinico, R, Spotti, D, Cadinu, F, Campieri, C, Capuano, M, Terribile, M, Cardone, F, Paglia, S, Castellino, P, Di Landro, D, Fatuzzo, P, Liuzzo, G, Sicurezza, E, Casu, M, Centrone, E, Ciofani, A, Cossu, M, D'Amaro, E, D'Apice, L, Dal Canton, A, Fasoli, G, De Ferrari, G, Cappelli, G, Gusmano, R, De Simone, W, Delgado, G, Di Iorio, B, Di Luca, M, Di Natale, E, Farfaglia, P, Cantù, P, Feriozzi, S, Galeotti, P, Fiorini, F, Frascà, G, Gallucci, M, Buongiorno, E, Gesualdo, L, Giannattasio, M, Detomaso, F, Giannetto, M, Gianni, S, Giliberti, A, Grassi, C, Lupi, G, Imperiali, P, Juliano, P, Li Vecchi, M, Lucenti, T, Maffucci, G, Anelli, A, Manno, M, Schena, F, Mazzaferro, S, Migliorati, M, Morrone, L, Mura, M, Petrarulo, F, Pizzarelli, F, Ricciardi, B, Riccobene, G, Rondanini, V, Russo, D, Sasdelli, M, Mura, C, Scarpino, L, Selvi, S, Tarchini, R, Tedesco, A, Timio, M, Traversari, L, Venditti, G, Viganò, S, Locatelli, F, SINICO, RENATO ALBERTO, Locatelli, F., Galassi, A, Andreucci, M, Caglioti, A, Faga, T, Mazzitello, G, Antonelli, A, Carlini, A, Giusti, R, Rosati, A, Apperti, V, Auricchio, M, Avella, F, Barbato, A, Romano, P, Barzaghi, B, Bedani, P, Bellinghieri, G, Costantino, G, Bernardi, A, Bolasco, P, Ferrara, R, Pani, A, Bonomini, M, Brancaccio, D, Busnach, G, Conte, F, Limido, A, Messa, P, Sinico, R, Spotti, D, Cadinu, F, Campieri, C, Capuano, M, Terribile, M, Cardone, F, Paglia, S, Castellino, P, Di Landro, D, Fatuzzo, P, Liuzzo, G, Sicurezza, E, Casu, M, Centrone, E, Ciofani, A, Cossu, M, D'Amaro, E, D'Apice, L, Dal Canton, A, Fasoli, G, De Ferrari, G, Cappelli, G, Gusmano, R, De Simone, W, Delgado, G, Di Iorio, B, Di Luca, M, Di Natale, E, Farfaglia, P, Cantù, P, Feriozzi, S, Galeotti, P, Fiorini, F, Frascà, G, Gallucci, M, Buongiorno, E, Gesualdo, L, Giannattasio, M, Detomaso, F, Giannetto, M, Gianni, S, Giliberti, A, Grassi, C, Lupi, G, Imperiali, P, Juliano, P, Li Vecchi, M, Lucenti, T, Maffucci, G, Anelli, A, Manno, M, Schena, F, Mazzaferro, S, Migliorati, M, Morrone, L, Mura, M, Petrarulo, F, Pizzarelli, F, Ricciardi, B, Riccobene, G, Rondanini, V, Russo, D, Sasdelli, M, Mura, C, Scarpino, L, Selvi, S, Tarchini, R, Tedesco, A, Timio, M, Traversari, L, Venditti, G, Viganò, S, Locatelli, F, SINICO, RENATO ALBERTO, and Locatelli, F.

Published
2010

29. Prevalence of Human Immunodeficiency Virus, Hepatitis B Virus and Hepatitis C Virus among Dialysis Patients

Author

Petrosillo, Nicola, primary, Puro, Vincenzo, additional, Ippolito, Giuseppe, additional, Campieri, C., additional, Arici, C., additional, Marchesi, D., additional, Beraldi, M.P., additional, Orazi, D., additional, Cesare, S., additional, Portelli, V., additional, Daglio, M., additional, Pedroni, G., additional, Vlacos, D., additional, Rosa, Dalla, additional, Pietrobon, F., additional, De Gennaro, M., additional, Maggi, P., additional, Volpe, Della, additional, Desperati, M., additional, Di Legge, R., additional, Francavilla, E., additional, Romagnoli, G.F., additional, Manescalchi, F., additional, Martinelli, F., additional, Migliori, M., additional, Soffritti, S., additional, Mirabella, C., additional, Petricca, S., additional, Poisetti, P.G., additional, Viale, P., additional, Rossi, G., additional, Tacconi, D., additional, Scaccia, F., additional, Simeoni, P.G., additional, Tanzariello, E., additional, and Zullo, G., additional

Published
1993
Full Text
View/download PDF

31. Impaired fecal elastase excretion in uremic pancreopathy.

Author

Ventrucci, Maurizio, Cipolla, Antonio, Middonno, Michele, Racchini, Chiara, Simoni, Patrizia, Afandi, Khaled, Grammatico, Francesco, Campieri, Claudio, Ventrucci, M, Cipolla, A, Middonno, M, Racchini, C, Simoni, P, Afandi, K, Grammatico, F, and Campieri, C

Abstract

To evaluate pancreatic exocrine function in uremia, 25 patients undergoing regular hemodialysis without clinical evidence of pancreatic disease and 25 healthy control subjects were studied by fecal elastase 1 and chymotrypsin. Abdominal ultrasonography and measurement of serum lipase, calcium, phosphate, and parathormone were also carried out. Fecal elastase was significantly lower (P < 0.001) in patients than in controls. Abnormally low values were found in 12/25 patients of whom six had values <100 microg/g. Fecal chymotrypsin was significantly lower (P < 0.05) in patients than in controls, with lower than normal values found in 10/25 patients. Fecal elastase was not related to the serum calcium, phosphate, or parathormone levels or to the period of dialysis. In patients serum lipase was normal or slightly elevated (<300 units/liter), and there was no evidence of pancreatic disease at ultrasound examination. The results lend further support to the existence of pancreatic function impairment in a significant number of patients with renal failure despite the absence of clinical and morphological evidence of pancreatic disease. [ABSTRACT FROM AUTHOR]

Published
2000
Full Text
View/download PDF

35. The natural history of hypertensive vascular nephropathy

Author

Vangelista A, Andrea Buscaroli, Campieri C, and Bonomini V

Subjects
Hypertension, Malignant, Renin-Angiotensin System, Hypertension, Renovascular, Humans, Kidney, Antihypertensive Agents, Renal Circulation
Published
1989

36. Is Ace inhibitor treatment a possible cause of better cardiovascular remodelling in well functioning kidney transplant?

Author

La Manna G, Campieri C, Dalmastri V, Andrea Buscaroli, Tarquinii M, Giudicissi A, Neri L, Pace G, Mosconi G, and Mp, Scolari

Subjects
Adult, Male, Echocardiography, Renal Dialysis, Humans, Angiotensin-Converting Enzyme Inhibitors, Female, Hypertrophy, Left Ventricular, Middle Aged, Kidney Transplantation, Ventricular Function, Left
Abstract

Diseases of the cardiovascular system are a common cause of death in renal transplanted patients. In this study we assessed the echocardiographic morphological and functional findings after renal transplantation of two homogenous groups of transplanted patients with normal renal function. The first (A) with spontaneously normotensive patients, the second (B) with moderate hypertension treated mainly with Ace inhibitors. Analysis of these data highlights two noteworthy results: the similar left ventricle hypertrophy found in both groups and the existence of better diastolic compliance among the hypertensive transplanted patients. If this is confirmed by studies currently in progress, the importance of Ace-inhibitors treatment in remodelling cardiac dysfunction after long term dialysis treatment might be seriously considered.

42. Family recurrence and oligo-anuria predict uremic restless legs syndrome

Author

F, Pizza, E, Persici, G, La Manna, C, Campieri, G, Plazzi, E, Carretta, M L, Cappuccilli, B, Ferri, S, Stefoni, P, Montagna, Pizza, F, Persici, E, La Manna, G, Campieri, C, Plazzi, G, Carretta, E, Cappuccilli, ML, Ferri, B, Stefoni, S, and Montagna, P

Subjects
Aged, 80 and over, Male, HEMODIALYSIS, RESTLESS LEGS SYNDROME, END-STAGE KIDNEY DISEASE, RESIDUAL DIURESIS, Peripheral Nervous System Diseases, PERIPHERAL NEUROPATHY, Middle Aged, Anuria, Sex Factors, Recurrence, Renal Dialysis, Risk Factors, mental disorders, Prevalence, Humans, Kidney Failure, Chronic, Female, Aged, Uremia
Abstract

Objectives - To determine clinical and laboratory predictors of restless legs syndrome (RLS) in patients with end-stage kidney disease (ESKD) undergoing long-term hemodialysis (HD). Materials and Methods - One hundred and sixty-two consecutive patients were assessed. History of sleep disturbances, neurological examination, clinical, and laboratory data were collected. Patients with and without RLS were compared, and a logistic regression model described the relations between independent predictors and RLS. Results - Fifty-one patients (32%) currently had RLS (RLS+). RLS+ vs RLS- patients were more frequently women (49% vs 29%, P = 0.012), had first-degree relative with RLS (22% vs 6%, P = 0.004), insomnia (59% vs 36%, P = 0.007), peripheral neuropathy (41% vs 21%, P = 0.006), and low residual diuresis (92% vs 68% with below 500 ml/24 h, P = 0.001). Low (OR = 8.71, CI = 2.27-33.41; P = 0.002) and absent (OR = 4.96, CI = 1.52-16.20; P = 0.008) residual diuresis, peripheral neuropathy (OR = 4.00, CI = 1.44-11.14; P = 0.008), and first-degree relative with RLS (OR = 3.82, CI = 1.21-12.13; P = 0.023) significantly predicted RLS in ESKD patients undergoing HD. Conclusion - Positive family history for RLS together with reduced/absent residual renal function and peripheral neuropathy predicts the risk for RLS in ESKD patients undergoing HD. Longitudinal studies are warranted to correlate RLS occurrence with genetic and environmental factors.

Published
2012

43. Group I nonreciprocal inhibition in restless legs syndrome secondary to chronic renal failure

Author

Giovanni Rizzo, Sara Marconi, Claudio Campieri, Paolo Martinelli, Pasquale Montagna, Gaetano La Manna, Sergio Stefoni, Fabio Pizza, Roberto Vetrugno, Cesa Scaglione, Giuseppe Plazzi, Marconi, S, Scaglione, C, Pizza, F, Rizzo, G, Plazzi, G, Vetrugno, R, La Manna, G, Campieri, C, Stefoni, S, Montagna, P, and Martinelli, P

Subjects
Adult, Male, RESTLESS LEGS SYNDROME, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Neural Conduction, Stimulation, Gastroenterology, Severity of Illness Index, Statistics, Nonparametric, H-Reflex, Polyneuropathies, Renal Dialysis, Internal medicine, Restless Legs Syndrome, mental disorders, medicine, Reaction Time, Humans, Restless legs syndrome, Muscle, Skeletal, Subclinical infection, Aged, Neurologic Examination, UREMIA, Analysis of Variance, business.industry, Neural Inhibition, Middle Aged, Spinal cord, medicine.disease, Pathophysiology, Uremia, Electric Stimulation, Surgery, medicine.anatomical_structure, Neurology, GROUP I NONRECIPROCAL (IB) INHIBITION, SPINAL REFLEXES, Kidney Failure, Chronic, Female, Neurology (clinical), Hemodialysis, Geriatrics and Gerontology, business, Polyneuropathy
Abstract

Background Neurophysiological investigations disclosed spinal cord hyperexcitability in primary restless legs syndrome (p-RLS). Uremic RLS (u-RLS) is the most common secondary form, but its pathophysiological mechanisms remain unsettled. Aim of this study was to explore spinal cord excitability by evaluating group I nonreciprocal (Ib) inhibition in u-RLS patients in comparison with p-RLS patients and healthy subjects. Methods Eleven u-RLS patients undergoing long-term hemodialysis treatment, nine p-RLS patients and ten healthy subjects were studied. Soleus H reflex latency (HR-L), H max / M max ratio, and Ib inhibition were evaluated. Ib inhibition was tested measuring the amplitude changes in soleus H reflex following stimulation of the synergist gastrocnemius medialis (GM) nerve at rest. Nerve conduction studies were performed in the uremic patients. Results The H max / M max ratio did not differ in the three groups. The u-RLS patients showed a normal Ib inhibition comparable with the healthy group, whereas the p-RLS group had evidence of a reduced active inhibition compared with both u-RLS patients (P = 0.04) and controls (P = 0.007), prominently at 5 ms (P = 0.007) and at 6 ms (P = 0.02) of conditioning-test interval. Neurophysiological examination disclosed abnormalities ranging from higher HR-L to clear-cut polyneuropathy in most u-RLS patients. Conclusions Unlike p-RLS patients, u-RLS patients had normal Ib inhibition, suggesting a regular supraspinal control of Ib spinal interneurons. Subclinical peripheral nerve abnormalities were detected in most uremic patients. Peripherally disrupted sensory modulation may represent the major pathophysiological determinant of uremic RLS.

Published
2011

44. Therapy strategies in the prevention of chronic allograft nephropathy

Author

SCOLARI, MARIA, CAPPUCCILLI, MARIA, COMAI, GIORGIA, PICCARI, MATTEO, ORTOLANI, MICHELA, CONTE, DILETTA, LANCI, NICOLE, BIANCHI, FRANCESCA, TODESCHINI, PAOLA, CAMPIERI, CLAUDIO, STEFONI, SERGIO, Scolari MP, Cappuccilli ML, Comai G, Piccari M, Ortolani M, Conte D, Lanci N, Bianchi F, Todeschini P, Campieri C, and Stefoni S.

Subjects
FTY720, Immunosuppressive therapy, Chronic allograft nephropathy, Calcineurin inhibitor, food and beverages, Kidney transplant, Nephrotoxicity
Abstract

Chronic allograft nephropathy (CAN) is an anatomical and clinical alteration, characterized by proteinuria, hypertension and a progressive decline in kidney function, which begins at variable times (months, years) and can lead to the loss of the transplanted organ. CAN pathogenesis, which remains to be fully clarified, involves both immunological (early acute rejection, hyperimmunization, HLA-mismatches between donor and recipient, suboptimal immunosuppression, etc) and non-immunological factors (ischemia/reperfusion injury, reduced nephron mass, age differences between donor and recipient, dialysis time, hypertension, dislipidemia, proteinuria, etc). The possible prevention strategies for CAN consist of procedures aimed at the reduction of some potential risk factors: optimization of the conditions for organ explantation, diminution of ischemia/reperfusion injury, aggressive pharmacological treatment of acute rejection episodes, routine utilization of anti-hypertensive and hypolipidemic agents, and appropriate and rational immunosuppressive regimen. Moreover, some categories of immunosuppressive drugs, such as calcineurin inhibitors, can have a nephrotoxic effect, often regardless of therapeutic dosage. The introduction in clinical practice of novel immunosuppressive drugs with no nephrotoxicity, like mycophenolate mofetil and rapamycin, makes therapeutical strategies able to reduce the incidence of CAN feasible.

Published
2005

45. Marcello Malpighi and his academic opponents in Bologna

Author

CAMPIERI, CLAUDIO, PERSICI, ELISA, STEFONI, SERGIO, Campieri C, Persici E, and Stefoni S.

Abstract

Marcello Malpighi was born in Crevalcore on March 10, 1628 and died in Rome on July 25, 1694. In Bologna he had among his opponents Giovanni Gerolamo Sbaraglia and Paoli Mini who prevented him being appointed to the chair of anatomy. This paper describes the reasons for this long term debate.

Published
2004

46. Clinical and neurophysiologic features of progressive myoclonus epilepsy without renal failure caused by SCARB2 mutations.

Author

Rubboli G, Franceschetti S, Berkovic SF, Canafoglia L, Gambardella A, Dibbens LM, Riguzzi P, Campieri C, Magaudda A, Tassinari CA, and Michelucci R

Subjects
Adult, Brain pathology, Electroencephalography, Electromyography, Female, Humans, Magnetic Resonance Imaging methods, Male, Myoclonic Epilepsies, Progressive complications, Myoclonic Epilepsies, Progressive pathology, Photic Stimulation, Reflex physiology, Renal Insufficiency complications, Renal Insufficiency genetics, Time Factors, Young Adult, Brain physiopathology, Evoked Potentials, Somatosensory physiology, Evoked Potentials, Visual physiology, Lysosomal Membrane Proteins genetics, Mutation genetics, Myoclonic Epilepsies, Progressive genetics, Receptors, Scavenger genetics
Abstract

Purpose: Mutations of the SCARB2 gene cause action myoclonus renal failure syndrome (AMRF), a rare condition that combines progressive myoclonus epilepsy (PME) with severe renal dysfunction. We describe the clinical and neurophysiologic features of PME associated with SCARB2 mutations without renal impairment., Methods: Clinical and neurophysiologic investigations, including wakefulness and sleep electroencephalography (EEG), polygraphic recording (with jerk-locked back-averaging and analysis of the EEG-EMG (electromyography) relationship by coherence spectra and phase calculation), multimodal evoked potentials, and electromyography were performed on five Italian patients with SCARB2 mutations., Key Findings: The main clinical features were adolescent-young adulthood onset, progressive action myoclonus, ataxia, absence of cognitive deterioration and, in most cases, epilepsy. The severity of the epilepsy could vary from uncontrolled seizures and status epilepticus in patients with adolescent onset to absent or rare seizures in patients with adult onset. Relevant neurophysiologic findings were a pronounced photosensitivity and massive action myoclonus associated with rhythmic myoclonic jerks at a frequency of 12-20 Hz, clinically resembling a postural tremor. The cortical origin of rhythmic myoclonus was demonstrated mainly by coherence and phase analysis of EEG-EMG signals indicating a significant EEG-EMG coupling and a direct corticospinal transfer., Significance: Our patients with SCARB2 mutations showed the clinical and neurophysiologic phenotype of PME, in which epilepsy could be extremely severe, extending the spectrum reported in the typical AMRF syndrome. Patients with PME of unknown origin of adolescent or young adult onset, with these neurophysiologic features, should be tested for SCARB2 mutations, even in the absence of renal impairment., (Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.)

Published
2011
Full Text
View/download PDF

47. [Therapy strategies in the prevention of chronic allograft nephropathy].

Author

Scolari MP, Cappuccilli ML, Comai G, Piccari M, Ortolani M, Conte D, Lanci N, Bianchi F, Todeschini P, Campieri C, and Stefoni S

Subjects
Chronic Disease, Humans, Immunosuppression Therapy, Kidney Diseases etiology, Kidney Diseases prevention & control, Kidney Transplantation adverse effects
Abstract

Chronic allograft nephropathy (CAN) is an anatomical and clinical alteration, characterized by proteinuria, hypertension and a progressive decline in kidney function, which begins at variable times (months, years) and can lead to the loss of the transplanted organ. CAN pathogenesis, which remains to be fully clarified, involves both immunological (early acute rejection, hyperimmunization, HLA-mismatches between donor and recipient, suboptimal immunosuppression, etc) and non-immunological factors (ischemia/reperfusion injury, reduced nephron mass, age differences between donor and recipient, dialysis time, hypertension, dislipidemia, proteinuria, etc). The possible prevention strategies for CAN consist of procedures aimed at the reduction of some potential risk factors: optimization of the conditions for organ explantation, diminution of ischemia/reperfusion injury, aggressive pharmacological treatment of acute rejection episodes, routine utilization of anti-hypertensive and hypolipidemic agents, and appropriate and rational immunosuppressive regimen. Moreover, some categories of immunosuppressive drugs, such as calcineurin inhibitors, can have a nephrotoxic effect, often regardless of therapeutic dosage. The introduction in clinical practice of novel immunosuppressive drugs with no nephrotoxicity, like mycophenolate mofetil and rapamycin, makes therapeutical strategies able to reduce the incidence of CAN feasible.

Published
2005

48. Marcello Malpighi and his academic opponents in Bologna.

Author

Campieri C, Persici E, and Stefoni S

Subjects
Histology history, History, 17th Century, Humans, Italy, Schools, Medical history, Schools, Medical organization & administration, Anatomy history, Dissent and Disputes history, Interprofessional Relations
Abstract

Marcello Malpighi was born in Crevalcore on March 10, 1628 and died in Rome on July 25, 1694. In Bologna he had among his opponents Giovanni Gerolamo Sbaraglia and Paoli Mini who prevented him being appointed to the chair of anatomy. This paper describes the reasons for this long term debate.

Published
2004

49. The history of clinical renal transplant.

Author

Stefoni S, Campieri C, Donati G, and Orlandi V

Subjects
History, 20th Century, Humans, Kidney Transplantation history
Abstract

After pioneeristic clinical and experimental work done by Jaboulay and Carrel in Lyon at the begining of the XX century, it was only in 1936 that Yu Yu Voronoy in Ukraine and then in 1945 Landsteiner and Hufnagel in Boston, USA, transplanted human kidneys. In 1955 Murray reported the first successful homotransplantation in identical twins and he later received the Nobel Prize in 1990 for this achievement. These milestones associated to the broadening of knowledge in the field of tissue typing, allowed the diffusion of kidney and other organ transplantation.

Published
2004

Catalog

Books, media, physical & digital resources
See catalog results