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12. Management of Pouchitis

Author

Gionchetti, Paolo, Morselli, Claudia, Rizzello, Fernando, Tambasco, Rosy, Poggioli, Gilberto, Laureti, Silvio, Ugolini, Federica, Pierangeli, Filippo, Campieri, Massimo, and Delaini, Gian Gaetano, editor

Published
2006
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20. Functional magnetic resonance imaging study reveals differences in the habituation to psychological stress in patients with Crohn's disease versus healthy controls

Author

Agostini, Alessandro, Filippini, Nicola, Benuzzi, Francesca, Bertani, Angela, Scarcelli, Antonella, Leoni, Chiara, Farinelli, Valentina, Riso, Donatella, Tambasco, Rosy, Calabrese, Carlo, Rizzello, Fernando, Gionchetti, Paolo, Ercolani, Mauro, Nichelli, Paolo, and Campieri, Massimo

Subjects
Neural circuitry -- Research -- Physiological aspects, Magnetic resonance imaging -- Usage, Crohn's disease -- Diagnosis -- Psychological aspects, Stress (Psychology) -- Risk factors, Psychology and mental health
Abstract

In patients with Crohn's disease (CD) stress is believed to increase the incidence of disease relapse. The brain processes stressful stimuli and triggers the stress-evoked responses. Habituation to stress is an adaptive process that allows minimizing these responses. We hypothesized inadequate habituation to stress in CD patients. The aim of this study was to compare the neural habituation between CD patients and controls. Twenty CD patients and eighteen controls underwent a functional magnetic resonance imaging while performing two repeated runs of a stress-evoking task. The task elicited different neural activity between the groups across runs in (1) amygdala, hippocampus, (2) insula, putamen (3) cerebellar regions, suggesting altered habituation to stress in patients. These structures regulate the neuroendocrine and autonomic stress-evoked responses that control the proinflammatory responses. The inadequate habituation to stress that we found in patients could play a role in the relationship between stress and inflammatory exacerbations in CD. Keywords Functional magnetic resonance imaging * Psychological stress * Habituation * Crohn's disease, Introduction Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is an idiopathic, chronic, inflammatory disorder of the bowel with a relapsing and remitting clinical course. In CD patients, [...]

Published
2013
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24. A phase II study of laquinimod in Crohnʼs disease

Author

DʼHaens, Geert, Sandborn, William J, Colombel, Jean Frederic, Rutgeerts, Paul, Brown, Kurt, Barkay, Hadas, Sakov, Anat, Haviv, Asi, Feagan, Brian G, Baert, Filip, Dupas, Jean-Louis, Bouhnik, Yoram, Bonaz, Bruno, Hebuterne, Xavier, Allez, Matthieu, Israeli, Eran, Fraser, Gerald, Segol, Ori, Fishman, Sigal, Lahat, Adi, Melzer, Ehud, Pallone, Francesco, Campieri, Massimo, Gasbarrini, Antonio, Kohn, Anna, Vecchi, Maurizo, Ponsioen, Cyriel, Van der Woude, Janneke, Rydzewska, Grazyna, Mach, Tomasz, Paradowski, Leszek, Wright, John Philip, Watermeyer, Gillian Ann, Pettengell, Keith Edward, Mahomed, Adam Dawood, Prins, Maarten Jeroen, Aboo, Nazimuddin, Diaz, Julian Panes, Taxonera, Carlos, Gisbert, Javier, Hinojosa, Joaquin, Garcia, Fernand Gomollon, Sanchez, Valle Garcia, Parkes, Miles, Probert, Chris, Leiper, Keith, Nwokolo, Chuka, Mayberry, John, and Bloom, Stuart

Published
2015
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28. Ulcerative Colitis

Author

Gilberto Poggioli, Carlo Calabrese, Luca Boschi, Andrea Calafiore, Lucia Calandrini, Campieri Massimo, Alberta Cappelli, Maurizio Coscia, Antonietta D'Errico, Massimo P. Di Simone, Lorenzo Gentilini, Federico Ghignone, Paolo Gionchetti, Silvio Laureti, Deborah Malvi, Marta Mazza, Chiara Praticò, Hana Privitera Hrustemovic, Nicola Renzi, Fernando Rizzello, Matteo Rottoli, Marco Salice, Carla Serra, Federica Ugolini, Laura Vittori, Gilberto Poggioli, Carlo Calabrese, Luca Boschi, Andrea Calafiore, Lucia Calandrini, Campieri Massimo, Alberta Cappelli, Maurizio Coscia, Antonietta D'Errico, Massimo P. Di Simone, Lorenzo Gentilini, Federico Ghignone, Paolo Gionchetti, Silvio Laureti, Deborah Malvi, Marta Mazza, Chiara Praticò, Hana Privitera Hrustemovic, Nicola Renzi, Fernando Rizzello, Matteo Rottoli, Marco Salice, Carla Serra, Federica Ugolini, and Laura Vittori

Subjects
Ulcerative Colitis
Abstract

None

Published
2019

42. Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease

Author

Belluzzi, Andrea, Brignola, Corrado, Campieri, Massimo, Pera, Angelo, Boschi, Stefano, and Miglioli, Mario

Subjects
Crohn's disease -- Diet therapy, Fish oils -- Evaluation, Enteric-coated tablets -- Evaluation
Abstract

Enteric-coated fish oil capsules may be beneficial in the treatment of Crohn's disease. Crohn's disease is an inflammatory bowel disease. Thirty-nine people in remission from Crohn's disease took three enteric-coated capsules containing 500 milligrams of fish oil three times a day and 39 took a placebo. They were examined at the beginning of the study and again at 3, 6, 9 and 12 months. Twenty-eight percent of those taking fish oil had a relapse, compared to 69% of those taking a placebo. At 12 months, 59% of those taking fish oil were still in remission, compared to 26% of those taking a placebo. Blood tests revealed a significant drop in chemicals involved in inflammatory processes in the people taking fish oil. Analysis of red blood cells from patients in remission indicated that the fatty acids in the fish oil had been incorporated into the red cell membranes. Four of those taking fish oil dropped out of the study because of diarrhea.

Published
1996

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