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62 results on '"Campos, S. M."'

2. Searching for Dark Matter with the Southern Wide-field Gamma-ray Observatory (SWGO)

Author

Viana, A., Albert, A., Harding, J. P., Hinton, J., Schoorlemmer, H., Souza, V., Abreu, P., Angüner, E. O., Arcaro, C., Arnaldi, L. H., Arteaga-Velázquez, J. C., Assis, P., Bakalová, A., Almeida, U. B., Batković, I., Bellido, J., Belmont-Moreno, E., Bisconti, F., Blanco, A., Bohacova, M., Bottacini, E., Bretz, T., Brisbois, C., Brogueira, P., Brown, A. M., Bulik, T., Mora, K. S. C., Campos, S. M., Chiavassa, A., Chytka, L., Ruben Conceição, Consolati, G., Paleta, J. C., Dasso, S., Angelis, A., Bom, C. R., La Fuente, E., Depaoli, D., Di Sciascio, G., Dib, C. O., Dorner, D., Doro, M., Du Vernois, M., Ergin, T., Fan, K. L., Fraija, N., Funk, S., García, J. I., García-González, J. A., García Roca, S. T., Giacinti, G., Goksu, H., González, B. S., Guarino, F., Guillén, A., Haist, F., Hansen, P. M., Hofmann, W., Hona, B., Hoyos, D., Huentemeyer, P., Hueyotl-Zahuantitla, F., Insolia, A., Janecek, P., Joshi, V., Khelifi, B., Kunwar, S., La Mura, G., Lapington, J., Laspiur, M. R., Leitl, F., Longo, F., Lopes, L., Lopez-Coto, R., Mandat, D., Mariazzi, A. G., Mariotti, M., Marques Moraes, A., Martínez-Castro, J., Martínez-Huerta, H., May, S., Melo, D. G., Mendes, L. F., Mendes, L. M., Mineeva, T., Mitchell, A., Mohan, S., Morales Olivares, O. G., Moreno-Barbosa, E., Nellen, L., Novotny, V., Olivera-Nieto, L., Orlando, E., Pech, M., Pichel, A., Pimenta, M., Albuquerque, M. P., Prandini, E., Rado Cuchills, M. S., Reisenegger, A., Reville, B., Rho, C. D., Rovero, A. C., Ruiz-Velasco, E., Salazar, G. A., Sandoval, A., Santander, M., Schüssler, F., Serrano, V. H., Shellard, R. C., Sinha, A., Smith, A. J., Surajbali, P., Tomé, B., Torres Aguilar, I., Eldik, C., Vergara-Quispe, I. D., Vícha, J., Vigorito, C. F., Wang, X., Werner, F., White, R., and Zamalloa Jara, M. A.

Subjects
Physics, Annihilation, Astrophysics::High Energy Astrophysical Phenomena, Galactic Center, Dark matter, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Galactic halo, SWGO - Abteilung Hinton, Observatory, Weakly interacting massive particles, Large Magellanic Cloud, Astrophysics::Galaxy Astrophysics, Dwarf galaxy
Abstract

Despite mounting evidence that dark matter (DM) exists in the Universe, its fundamental nature remains unknown. We present sensitivity estimates to detect DM particles with a future very-high-energy ($\gtrsim$ TeV) wide field-of-view gamma-ray observatory in the Southern Hemisphere, currently in its research and development phase under the name Southern Wide field-of-view Gamma-ray Observatory (SWGO). This observatory would search for gamma rays from the annihilation or decay of DM particles in many key targets in the Southern sky, such as the Galactic halo, several dwarf galaxies, including the promising Reticulum II, and the Large Magellanic Cloud. With a wide field of view and long exposures, such observatory will have unprecedented sensitivity to DM in the mass range of $\sim$100 GeV to a few PeV from observations of a large fraction of the Galactic halo around the Galactic Center and from Galactic subhalos targets. These results, combined with those from other present and future gamma-ray observatories, will likely probe the thermal relic annihilation cross section of Weakly Interacting Massive Particles for all masses from $\sim$80 TeV down to the GeV range in most annihilation channels.

Published
2022

3. The Southern Wide-field Gamma-ray Observatory reach for Primordial Black Hole evaporation

Author

Abreu, P., Albert, A., Angüner, E. O., Arcaro, C., Arnaldi, L. H., Arteaga-Velázquez, J. C., Assis, P., Bakalová, A., Almeida, U. B., Batković, I., Bellido, J., Belmont-Moreno, E., Bisconti, F., Blanco, A., Bohacova, M., Bottacini, E., Bretz, T., Brisbois, C., Brogueira, P., Brown, A. M., Bulik, T., Caballero Mora, K. S., Campos, S. M., Chiavassa, A., Chytka, L., Conceição, R., Consolati, G., Cotzomi Paleta, J., Dasso, S., Angelis, A., Bom, C. R., La Fuente, E., Souza, V., Depaoli, D., Di Sciascio, G., Dib, C. O., Dorner, D., Doro, M., Du Vernois, M., Ergin, T., Fan, K. L., Fraija, N., Funk, S., García, J. I., García-González, J. A., García Roca, S. T., Giacinti, G., Goksu, H., González, B. S., Guarino, F., Guillén, A., Haist, F., Hansen, P. M., Harding, J. P., Hinton, J., Hofmann, W., Hona, B., Hoyos, D., Huentemeyer, P., Hueyotl-Zahuantitla, F., Insolia, A., Janecek, P., Joshi, V., Khelifi, B., Samridha Kunwar, La Mura, G., Lapington, J., Laspiur, M. R., Leitl, F., Longo, F., Lopes, L., Lopez-Coto, R., Mandat, D., Mariazzi, A. G., Mariotti, M., Marques Moraes, A., Martínez-Castro, J., Martínez-Huerta, H., May, S., Melo, D. G., Mendes, L. F., Mendes, L. M., Mineeva, T., Mitchell, A., Mohan, S., Morales Olivares, O. G., Moreno-Barbosa, E., Nellen, L., Novotny, V., Olivera-Nieto, L., Orlando, E., Pech, M., Pichel, A., Pimenta, M., Albuquerque, M. P., Prandini, E., Rado Cuchills, M. S., Reisenegger, A., Reville, B., Rho, C. D., Rovero, A. C., Ruiz-Velasco, E., Salazar, G. A., Sandoval, A., Santander, M., Schoorlemmer, H., Schüssler, F., Serrano, V. H., Shellard, R. C., Sinha, A., Smith, A. J., Surajbali, P., Tomé, B., Torres Aguilar, I., Eldik, C., Vergara-Quispe, I. D., Viana, A., Vícha, J., Vigorito, C. F., Wang, X., Werner, F., White, R., and Zamalloa Jara, M. A.

Published
2022

4. Monitoring Gamma-Ray Burst VHE emission with the Southern Wide-field-of-view Gamma-ray Observatory

Author

La Mura, G., Abreu, P., Albert, A., Angüner, E. O., Arcaro, C., Arnaldi, L. H., Arteaga-Velázquez, J. C., Assis, P., Bakalová, A., Barres Almeida, U., Batković, I., Bellido, J., Belmont-Moreno, E., Bisconti, F., Blanco, A., Bohacova, M., Bottacini, E., Bretz, T., Brisbois, C., Brogueira, P., Brown, A. M., Bulik, T., Caballero Mora, K. S., Campos, S. M., Chiavassa, A., Chytka, L., Conceição, R., Consolati, G., Cotzomi Paleta, J., Dasso, S., Angelis, A., Bom, C. R., La Fuente, E., Souza, V., Depaoli, D., Di Sciascio, G., Dib, C. O., Dorner, D., Doro, M., Du Vernois, M., Ergin, T., Fan, K. L., Fraija, N., Funk, S., García, J. I., García-González, J. A., García Roca, S. T., Giacinti, G., Goksu, H., González, B. S., Guarino, F., Guillén, A., Haist, F., Hansen, P. M., Harding, J. P., Hinton, J., Hofmann, W., Hona, B., Hoyos, D., Huentemeyer, P., Hueyotl-Zahuantitla, F., Insolia, A., Janecek, P., Joshi, V., Khelifi, B., Samridha Kunwar, Lapington, J., Laspiur, M. R., Leitl, F., Longo, F., Lopes, L., Lopez-Coto, R., Mandat, D., Mariazzi, A. G., Mariotti, M., Marques Moraes, A., Martínez-Castro, J., Martínez-Huerta, H., May, S., Melo, D. G., Mendes, L. F., Mendes, L. M., Mineeva, T., Mitchell, A., Mohan, S., Morales Olivares, O. G., Moreno-Barbosa, E., Nellen, L., Novotny, V., Olivera-Nieto, L., Orlando, E., Pech, M., Pichel, A., Pimenta, M., Portes Albuquerque, M., Prandini, E., Rado Cuchills, M. S., Reisenegger, A., Reville, B., Rho, C. D., Rovero, A. C., Ruiz-Velasco, E., Salazar, G. A., Sandoval, A., Santander, M., Schoorlemmer, H., Schüssler, F., Serrano, V. H., Shellard, R. C., Sinha, A., Smith, A. J., Surajbali, P., Tomé, B., Torres Aguilar, I., Eldik, C., Vergara-Quispe, I. D., Viana, A., Vícha, J., Vigorito, C. F., Wang, X., Werner, F., White, R., and Zamalloa Jara, M. A.

Subjects
Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Observatory, Astrophysics::High Energy Astrophysical Phenomena, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astrophysics, Gamma-ray burst, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Wide field, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

It has been established that Gamma-Ray Bursts (GRB) can produce Very High Energy radiation (E > 100 GeV), opening a new window on the investigation of particle acceleration and radiation properties in the most energetic domain. We expect that next-generation instruments, such as the Cherenkov Telescope Array (CTA), will mark a huge improvement in their observation. However, constraints on the target visibility and the limited duty cycle of Imaging Atmospheric Cherenkov Telescopes (IACT) reduce their ability to react promptly to transient events and to characterise their general properties. Here we show that an instrument based on the Extensive Air Shower (EAS) array concept, proposed by the Southern Wide Field-of-view Gamma-ray Observatory (SWGO) Collaboration, has promising possibilities to detect and track VHE emission from GRBs. Observations made by the Fermi Large Area Telescope (Fermi-LAT) identified some events with a distinct spectral component, extending above $1\,$GeV or even $10\,$GeV, which can represent a substantial fraction of the emitted energy and also arise in early stages of the process. Using models based on these properties, we estimate the possibilities that a wide field of view and large effective area ground-based monitoring facility has to probe VHE emission from GRBs. We show that the ability to monitor VHE transients with a nearly continuous scanning of the sky grants an opportunity to access simultaneous electromagnetic counterparts to Multi-Messenger triggers up to cosmological scales, in a way that is not available to IACTs., Proceedings of the 37th International Cosmic-Ray Conference. Accepted by PoS

Published
2021

5. Technological options for the Southern Wide-field Gamma-ray Observatory (SWGO) and current design status

Author

Werner, F., Nellen, L., Abreu, P., Albert, A., Angüner, E. O., Arcaro, C., Arnaldi, L. H., Arteaga-Velázquez, J. C., Assis, P., Bakalová, A., Barres Almeida, U., Batković, I., Bellido, J., Belmont-Moreno, E., Bisconti, F., Blanco, A., Bohacova, M., Bottacini, E., Bretz, T., Brisbois, C., Brogueira, P., Brown, A. M., Bulik, T., Caballero Mora, K. S., Campos, S. M., Chiavassa, A., Chytka, L., Ruben Conceição, Consolati, G., Cotzomi Paleta, J., Dasso, S., Angelis, A., Bom, C. R., La Fuente, E., Souza, V., Depaoli, D., Di Sciascio, G., Dib, C. O., Dorner, D., Doro, M., Du Vernois, M., Ergin, T., Fan, K. L., Fraija, N., Funk, S., García, J. I., García-González, J. A., García Roca, S. T., Giacinti, G., Goksu, H., González, B. S., Guarino, F., Guillén, A., Haist, F., Hansen, P. M., Harding, J. P., Hinton, J., Hofmann, W., Hona, B., Hoyos, D., Huentemeyer, P., Hueyotl-Zahuantitla, F., Insolia, A., Janecek, P., Joshi, V., Khelifi, B., Kunwar, S., La Mura, G., Lapington, J., Laspiur, M. R., Leitl, F., Longo, F., Lopes, L., Lopez-Coto, R., Mandat, D., Mariazzi, A. G., Mariotti, M., Marques Moraes, A., Martínez-Castro, J., Martínez-Huerta, H., May, S., Melo, D. G., Mendes, L. F., Mendes, L. M., Mineeva, T., Mitchell, A., Mohan, S., Morales Olivares, O. G., Moreno-Barbosa, E., Novotny, V., Olivera-Nieto, L., Orlando, E., Pech, M., Pichel, A., Pimenta, M., Portes Albuquerque, M., Prandini, E., Rado Cuchills, M. S., Reisenegger, A., Reville, B., Rho, C. D., Rovero, A. C., Ruiz-Velasco, E., Salazar, G. A., Sandoval, A., Santander, M., Schoorlemmer, H., Schüssler, F., Serrano, V. H., Shellard, R. C., Sinha, A., Smith, A. J., Surajbali, P., Tomé, B., Torres Aguilar, I., Eldik, C., Vergara-Quispe, I. D., Viana, A., Vícha, J., Vigorito, C. F., Wang, X., White, R., and Zamalloa Jara, M. A.

Subjects
Cost estimate, Work (electrical), SWGO - Abteilung Hinton, Duty cycle, Process (engineering), Computer science, Observatory, Detector, Systems engineering, Systems design, Wide field
Abstract

The SWGO Collaboration is in the process of designing and prototyping a wide field of view, high duty cycle complement to CTA and the existing ground-based particle detectors of the Northern Hemisphere (HAWC and LHAASO). In this contribution, we will compare the various technological options for designing the detector and present an overarching system design accommodating them. We will introduce a feasible reference configuration that is used for the first large-scale simulations and cost estimates, and show ongoing prototyping work focused on reaching a maintenance-free and cost-effective detector.

Published
2021

6. Double-layered Water Cherenkov Detector for SWGO

Author

Samridha Kunwar, Abreu, P., Albert, A., Angüner, E. O., Arcaro, C., Arnaldi, L. H., Arteaga-Velázquez, J. C., Assis, P., Bakalová, A., Almeida, U. B., Batković, I., Bellido, J., Belmont-Moreno, E., Bisconti, F., Blanco, A., Bohacova, M., Bottacini, E., Bretz, T., Brisbois, C., Brogueira, P., Brown, A. M., Bulik, T., Mora, K. S. C., Campos, S. M., Chiavassa, A., Chytka, L., Conceição, R., Consolati, G., Paleta, J. C., Dasso, S., Angelis, A., Bom, C. R., La Fuente, E., Souza, V., Depaoli, D., Di Sciascio, G., Dib, C. O., Dorner, D., Doro, M., Du Vernois, M., Ergin, T., Fan, K. L., Fraija, N., Funk, S., García, J. I., García-González, J. A., Roca, S. T. G., Giacinti, G., Goksu, H., González, B. S., Guarino, F., Guillén, A., Haist, F., Hansen, P. M., Harding, J. P., Hinton, J., Hofmann, W., Hona, B., Hoyos, D., Huentemeyer, P., Hueyotl-Zahuantitla, F., Insolia, A., Janecek, P., Joshi, V., Khelifi, B., La Mura, G., Lapington, J., Laspiur, M. R., Leitl, F., Longo, F., Lopes, L., Lopez-Coto, R., Mandat, D., Mariazzi, A. G., Mariotti, M., Moraes, A. M., Martínez-Castro, J., Martínez-Huerta, H., May, S., Melo, D. G., Mendes, L. F., Mendes, L. M., Mineeva, T., Mitchell, A., Mohan, S., Olivares, O. G. M., Moreno-Barbosa, E., Nellen, L., Novotny, V., Olivera-Nieto, L., Orlando, E., Pech, M., Pichel, A., Pimenta, M., Albuquerque, M. P., Prandini, E., Cuchills, M. S. R., Reisenegger, A., Reville, B., Rho, C. D., Rovero, A. C., Ruiz-Velasco, E., Salazar, G. A., Sandoval, A., Santander, M., Schoorlemmer, H., Schüssler, F., Serrano, V. H., Shellard, R. C., Sinha, A., Smith, A. J., Surajbali, P., Tomé, B., Aguilar, I. T., Eldik, C., Vergara-Quispe, I. D., Viana, A., Vícha, J., Vigorito, C. F., Wang, X., Werner, F., White, R., and Jara, M. A. Z.

Subjects
Physics, Muon, Physics::Instrumentation and Detectors, business.industry, Cherenkov detector, Astrophysics::High Energy Astrophysical Phenomena, Detector, Photodetector, Aspect ratio (image), law.invention, Optics, SWGO - Abteilung Hinton, law, Observatory, High Energy Physics::Experiment, business, Sensitivity (electronics), Cherenkov radiation
Abstract

The Southern Wide-field Gamma-ray Observatory (SWGO) will use the well-established and cost-effective technique of detecting Cherenkov light produced in water-filled detection units for TeV gamma-ray astronomy. Leveraging detector material reflectivity together with an optimised aspect ratio is an option to improve the performance of an array of such detector units. The double-layered Water Cherenkov Detector units comprise chambers with single photosensors in each. A reflective upper compartment enhances sensitivity to impinging secondary particles. A shallow lower compartment enables muon tagging and consequently improves the gamma hadron separation power of the observatory. Here we present detailed studies on the double-layered unit design.

Published
2021

7. Benchmarking the Science for the Southern Wide-Field Gamma-ray Observatory (SWGO)

Author

Abreu, P., Albert, A., Angüner, E. O., Arcaro, C., Arnaldi, L. H., Arteaga-Velázquez, J. C., Assis, P., Bakalová, A., Almeida, U. B., Batković, I., Bellido, J., Belmont-Moreno, E., Bisconti, F., Blanco, A., Bohacova, M., Bottacini, E., Bretz, T., Brisbois, C., Brogueira, P., Brown, A. M., Bulik, T., Caballero Mora, K. S., Campos, S. M., Chiavassa, A., Chytka, L., Conceição, R., Consolati, G., Cotzomi Paleta, J., Dasso, S., Angelis, A., Bom, C. R., La Fuente, E., Souza, V., Depaoli, D., Di Sciascio, G., Dib, C. O., Dorner, D., Doro, M., Du Vernois, M., Ergin, T., Fan, K. L., Fraija, N., Funk, S., García, J. I., García-González, J. A., García Roca, S. T., Giacinti, G., Goksu, H., González, B. S., Guarino, F., Guillén, A., Haist, F., Hansen, P. M., Harding, J. P., Hinton, J., Hofmann, W., Hona, B., Hoyos, D., Huentemeyer, P., Hueyotl-Zahuantitla, F., Insolia, A., Janecek, P., Joshi, V., Khelifi, B., Samridha Kunwar, La Mura, G., Lapington, J., Laspiur, M. R., Leitl, F., Longo, F., Lopes, L., Lopez-Coto, R., Mandat, D., Mariazzi, A. G., Mariotti, M., Marques Moraes, A., Martínez-Castro, J., Martínez-Huerta, H., May, S., Melo, D. G., Mendes, L. F., Mendes, L. M., Mineeva, T., Mitchell, A., Mohan, S., Morales Olivares, O. G., Moreno-Barbosa, E., Nellen, L., Novotny, V., Olivera-Nieto, L., Orlando, E., Pech, M., Pichel, A., Pimenta, M., Albuquerque, M. P., Prandini, E., Rado Cuchills, M. S., Reisenegger, A., Reville, B., Rho, C. D., Rovero, A. C., Ruiz-Velasco, E., Salazar, G. A., Sandoval, A., Santander, M., Schoorlemmer, H., Schüssler, F., Serrano, V. H., Shellard, R. C., Sinha, A., Smith, A. J., Surajbali, P., Tomé, B., Torres Aguilar, I., Eldik, C., Vergara-Quispe, I. D., Viana, A., Vícha, J., Vigorito, C. F., Wang, X., Werner, F., White, R., and Zamalloa Jara, M. A.

Subjects
Observatory, Gamma ray, Environmental science, Astronomy, Benchmarking, Wide field
Published
2021

8. Galactic Science with the Southern Wide-field Gamma-ray Observatory

Author

Abreu, P., Albert, A., Angüner, E. O., Arcaro, C., Arnaldi, L. H., Arteaga-Velázquez, J. C., Assis, P., Bakalová, A., Almeida, U. B., Batković, I., Bellido, J., Belmont-Moreno, E., Bisconti, F., Blanco, A., Bohacova, M., Bottacini, E., Bretz, T., Brisbois, C., Brogueira, P., Brown, A. M., Bulik, T., Caballero Mora, K. S., Campos, S. M., Chiavassa, A., Chytka, L., Ruben Conceição, Consolati, G., Cotzomi Paleta, J., Dasso, S., Angelis, A., Bom, C. R., La Fuente, E., Souza, V., Depaoli, D., Di Sciascio, G., Dib, C. O., Dorner, D., Doro, M., Du Vernois, M., Ergin, T., Fan, K. L., Fraija, N., Funk, S., García, J. I., García-González, J. A., García Roca, S. T., Giacinti, G., Goksu, H., González, B. S., Guarino, F., Guillén, A., Haist, F., Hansen, P. M., Harding, J. P., Hinton, J., Hofmann, W., Hona, B., Hoyos, D., Huentemeyer, P., Hueyotl-Zahuantitla, F., Insolia, A., Janecek, P., Joshi, V., Khelifi, B., Kunwar, S., La Mura, G., Lapington, J., Laspiur, M. R., Leitl, F., Longo, F., Lopes, L., Lopez-Coto, R., Mandat, D., Mariazzi, A. G., Mariotti, M., Marques Moraes, A., Martínez-Castro, J., Martínez-Huerta, H., May, S., Melo, D. G., Mendes, L. F., Mendes, L. M., Mineeva, T., Mitchell, A., Mohan, S., Morales Olivares, O. G., Moreno-Barbosa, E., Nellen, L., Novotny, V., Olivera-Nieto, L., Orlando, E., Pech, M., Pichel, A., Pimenta, M., Albuquerque, M. P., Prandini, E., Rado Cuchills, M. S., Reisenegger, A., Reville, B., Rho, C. D., Rovero, A. C., Ruiz-Velasco, E., Salazar, G. A., Sandoval, A., Santander, M., Schoorlemmer, H., Schüssler, F., Serrano, V. H., Shellard, R. C., Sinha, A., Smith, A. J., Surajbali, P., Tomé, B., Torres Aguilar, I., Eldik, C., Vergara-Quispe, I. D., Viana, A., Vícha, J., Vigorito, C. F., Wang, X., Werner, F., White, R., Zamalloa Jara, M. A., Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and SWGO

Subjects
Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics::High Energy Astrophysical Phenomena, Detector, Gamma rays, Gamma ray, Astronomy, FOS: Physical sciences, Galaxy, Cosmology, Tellurium compounds, Pulsar, SWGO - Abteilung Hinton, Observatory, Angular resolution, Halo, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Southern Hemisphere, Astrophysics::Galaxy Astrophysics, Pulsars
Abstract

The Southern Wide-field Gamma-ray Observatory (SWGO) is a proposed ground-based gamma-ray detector that will be located in the Southern Hemisphere and is currently in its design phase. In this contribution, we will outline the prospects for Galactic science with this Observatory. Particular focus will be given to the detectability of extended sources, such as gamma-ray halos around pulsars; optimisation of the angular resolution to mitigate source confusion between known TeV sources; and studies of the energy resolution and sensitivity required to study the spectral features of PeVatrons at the highest energies. Such a facility will ideally complement contemporaneous observatories in studies of high energy astrophysical processes in our Galaxy., PoS: Proceedings of Science, 395, ISSN:1824-8039, 37th International Cosmic Ray Conference (ICRC 2021)

Published
2021

9. Mekuido: intervención en línea para escolares chilenos de apoyo a la prevención del sobrepeso

Author

Campos S, M. Cecilia, Jaimovich P, Sonia, Campos, María Sylvia, Herrera L, Luz María, Lillo S, Verónica, Martínez S, Dayann, Del Río C, María Paz, and Arellano F, Valentina

Subjects
conducta alimentaria, obesity, sobrepeso, self care, overweight, feeding behavior, Nutrición escolar, obesidad, autocuidado, Child nutrition
Abstract

Se describe la intervención MeKuido disenada para el proyecto "Prevención del sobrepeso y de la obesidad en escolares chilenos: Apuesta a la capacidad emprendedora de los niños" (FONIS SA10I20016). Sujetos y Método: Estudio descriptivo de la intervención realizada a población seleccionada mediante muestreo aleatorio por conglomerado del 50% de los colegios municipalizados de la comuna de La Pintana, conformada por los niños/as que en marzo de 2011, cursaban 5° y 6° año básico, (n=468) y aceptaron participar. Mekuido elemento central de la intervención, es un software con cuatro secciones construidas según marco referencial Orem. Post intervención, se aplicó cuestionario de satisfacción. Resultados: La implementación en el contexto de las actividades escolares demostró ser factible, pero no exenta de dificultades. El cuestionario de satisfacción fue respondido por 355 niños/as (90,8%). En todas las preguntas cerradas más del 80% muestran satisfacción con la intervención y recomendarían su uso. Conclusiones. El marco de referencia de Orem permite diseñar intervenciones para cambio de conductas asociadas a alimentación. Su uso es factible en el contexto escolar, requiere de decisión y compromiso de los profesores. La estrategia puede ser incorporada al curriculum y contribuir al desarrollo de objetivos transversales. La satisfacción con la intervención fue alta. The MeKuido intervention is described, designed for the project "Prevention of overweight and obesity in Chilean children: Bettinhg on the enterprising capacity of children" (FONIS SA10I20016). Subjects and Method: A descriptive intervention study on a randomly selected population by cluster at 50% of municipal schools in the district of La Pintana, with children enrolled in 5th and 6th grade of primary school who agreed to participate (n = 468). Mekuido, central element is a software with four sections built according to Orem's referential framework. Post intervention, a satisfaction questionnaire was applied. Results: The implementation in the context of school activities proved feasible but not without difficulties. The satisfaction questionnaire was answered by 355 children (90.8%). All closed questions showed over 80% of satisfaction with the intervention and would recommend their use. Conclusion: The Orem framework allows the design of interventions to change behaviors related to feeding. Its use is feasible in the school context, requires determination and commitment of teachers. The strategy can be incorporated into the curriculum and contribute to the development of transversal objectives.

Published
2013

10. Educação ambiental na formação da consciência e prática ambiental em uma escola pública do município de BenjaminConstant-am.

Author

Campos, S. M., Alves, C. N., Gomez, D. M., and Souza, J. S.

Abstract

Este trabalho apresenta uma discussão acerca da Educação Ambiental na formação da consciência e prática ambiental em uma escola pública do município de Benjamin Constant-Amazonas. Sendo um capítulo de uma pesquisa para a qualificação do mestrado pela Universidade Federal do Pará. Realizou-se o método de abordagem dialético, os instrumentos de coletas de dados foram: observação participante e pesquisa ação. Diante disso, necessita que as escolas desenvolvam iniciativas de um planejamento participativo teórico metodológico interdisciplinar do tema transversal Meio Ambiente na educação básica com o intuito de superar os entraves em relação às questões ambientais no contexto educacional, social e local. Que elas executem o planejamento pedagógico do tema transversal de forma permanente nas escolas e não apenas na semana do Meio Ambiente; Sugerem-se também, que paralelamente ao planejamento participativo coletivo permanente, elas possam desenvolver projetos socioeducativos ambientais durante o ano letivo. E, façam parcerias com a Secretaria do Meio Ambiente, na atuação eficaz acerca da educação ambiental na sociedade Benjaminense. Enfim, carece de um investimento na educação e na Secretaria do Meio Ambiente local para que os estudantes no desenvolvimento da formação intelectual adotem posturas pessoais, comportamentais e sociais na colaboração para a construção de uma sociedade ativa que discuta as problemáticas ambientais emergentes no mundo, na nação e no município de Benjamin Constant no Amazonas. [ABSTRACT FROM AUTHOR]

Published
2018

29. Simulating the performance of the Southern Wide-view Gamma-ray Observatory

Author

Schoorlemmer, H., Conceição, R., Smith, A. J., Abreu, P., Albert, A., Angüner, E. O., Arcaro, C., Arnaldi, L. H., Arteaga-Velázquez, J. C., Assis, P., Bakalová, A., Almeida, U. B., Batković, I., Bellido, J., Belmont-Moreno, E., Bisconti, F., Blanco, A., Bohacova, M., Bottacini, E., Bretz, T., Brisbois, C., Brogueira, P., Brown, A. M., Bulik, T., Mora, K. S. C., Campos, S. M., Chiavassa, A., Chytka, L., Consolati, G., Paleta, J. C., Dasso, S., Angelis, A., Bom, C. R., La Fuente, E., Souza, V., Depaoli, D., Di Sciascio, G., Dib, C. O., Dorner, D., Doro, M., Du Vernois, M., Ergin, T., Fan, K. L., Fraija, N., Funk, S., García, J. I., García-González, J. A., Roca, S. T. G., Giacinti, G., Goksu, H., González, B. S., Guarino, F., Guillén, A., Haist, F., Hansen, P. M., Harding, J. P., Hinton, J., Hofmann, W., Hona, B., Hoyos, D., Huentemeyer, P., Hueyotl-Zahuantitla, F., Insolia, A., Janecek, P., Joshi, V., Khelifi, B., Samridha Kunwar, La Mura, G., Lapington, J., Laspiur, M. R., Leitl, F., Longo, F., Lopes, L., Lopez-Coto, R., Mandat, D., Mariazzi, A. G., Mariotti, M., Moraes, A. M., Martínez-Castro, J., Martínez-Huerta, H., May, S., Melo, D. G., Mendes, L. F., Mendes, L. M., Mineeva, T., Mitchell, A., Mohan, S., Olivares, O. G. M., Moreno-Barbosa, E., Nellen, L., Novotny, V., Olivera-Nieto, L., Orlando, E., Pech, M., Pichel, A., Pimenta, M., Albuquerque, M. P., Prandini, E., Cuchills, M. S. R., Reisenegger, A., Reville, B., Rho, C. D., Rovero, A. C., Ruiz-Velasco, E., Salazar, G. A., Sandoval, A., Santander, M., Schüssler, F., Serrano, V. H., Shellard, R. C., Sinha, A., Surajbali, P., Tomé, B., Aguilar, I. T., Eldik, C., Vergara-Quispe, I. D., Viana, A., Vícha, J., Vigorito, C. F., Wang, X., Werner, F., White, R., and Jara, M. A. Z.

Subjects
SWGO - Abteilung Hinton, Observatory, Astrophysics::High Energy Astrophysical Phenomena, Detector, Large array, Astrophysics::Instrumentation and Methods for Astrophysics, Elevation, Gamma ray, Phase (waves), Environmental science, Remote sensing
Abstract

The Southern Wide-view Gamma-ray Observatory (SWGO) will be a next-generation gamma-ray observatory using a large array of particle detectors at a high elevation site in South America. This project is currently in a three years R & D phase in which the design will be optimised for cost and performance. Therefore it is crucial to efficiently evaluate the impact of different design options on the scientific objectives of the observatory. In this contribution, we will introduce the strategy and the simulation framework in which this evaluation takes place.

30. Gamma/hadron discrimination using a small-WCD with four PMTs

Author

Ruben Conceição, Assis, P., Assunção, F., Bakalová, A., Barres Almeida, U., Bom, C. R., Correia, J., Angelis, A., Dias, L., González, B. S., Guillén, A., La Mura, G., Lourenço, N., Machado, P., Marques, S., Mendes, L., Pimenta, M., Shellard, R., Tomé, B., Vicha, J., Abreu, P., Albert, A., Angüner, E. O., Arcaro, C., Arnaldi, L. H., Arteaga-Velázquez, J. C., Batković, I., Bellido, J., Belmont-Moreno, E., Bisconti, F., Blanco, A., Bohacova, M., Bottacini, E., Bretz, T., Brisbois, C., Brogueira, P., Brown, A. M., Bulik, T., Caballero Mora, K. S., Campos, S. M., Chiavassa, A., Chytka, L., Consolati, G., Cotzomi Paleta, J., Dasso, S., La Fuente, E., Souza, V., Depaoli, D., Di Sciascio, G., Dib, C. O., Dorner, D., Doro, M., Du Vernois, M., Ergin, T., Fan, K. L., Fraija, N., Funk, S., García, J. I., García-González, J. A., García Roca, S. T., Giacinti, G., Goksu, H., Guarino, F., Haist, F., Hansen, P. M., Harding, J. P., Hinton, J., Hofmann, W., Hona, B., Hoyos, D., Huentemeyer, P., Hueyotl-Zahuantitla, F., Insolia, A., Janecek, P., Joshi, V., Khelifi, B., Kunwar, S., Lapington, J., Laspiur, M. R., Leitl, F., Longo, F., Lopes, L., Lopez-Coto, R., Mandat, D., Mariazzi, A. G., Mariotti, M., Marques Moraes, A., Martínez-Castro, J., Martínez-Huerta, H., May, S., Melo, D. G., Mendes, L. F., Mendes, L. M., Mineeva, T., Mitchell, A., Mohan, S., Morales Olivares, O. G., Moreno-Barbosa, E., Nellen, L., Novotny, V., Olivera-Nieto, L., Orlando, E., Pech, M., Pichel, A., Portes Albuquerque, M., Prandini, E., Rado Cuchills, M. S., Reisenegger, A., Reville, B., Rho, C. D., Rovero, A. C., Ruiz-Velasco, E., Salazar, G. A., Sandoval, A., Santander, M., Schoorlemmer, H., Schüssler, F., Serrano, V. H., Shellard, R. C., Sinha, A., Smith, A. J., Surajbali, P., Torres Aguilar, I., Eldik, C., Vergara-Quispe, I. D., Viana, A., Vigorito, C. F., Wang, X., Werner, F., White, R., and Zamalloa Jara, M. A.

Subjects
Physics, Muon, Observatory, Astrophysics::High Energy Astrophysical Phenomena, Detector, Hadron, Astrophysics::Instrumentation and Methods for Astrophysics, Phase (waves), Elevation, Square (algebra), Cherenkov radiation, Remote sensing
Abstract

The Southern Wide-field Gamma-ray Observatory (SWGO) is the next-generation gamma-ray observatory, currently in an R\&D phase. The experiment is expected to have a large array of water Cherenkov detectors (WCD) placed at a high elevation (> 4.4 km a.s.l.) in South America. Here we present a WCD concept with reduced surface area and height of stations comprising four PMTs at the bottom. We show that it is possible to reach an excellent gamma/hadron discrimination by analysing the data gathered by this station with machine learning techniques. Such performance can be achieved by analysing the shower patterns at the ground or through the PMTs signal time structure to tag muons. Moreover, it is shown that the station's performance does not depend on the array configuration (dense or sparse) nor on the shower inclination ($\theta < 40^\circ$). Such a concept reduces the cost associated with the transport of massive amounts of water to high elevation sites while keeping a high physics performance. Therefore, it could be a good candidate station for SWGO, enabling to reach good sensitivities from low energies ($\sim 100\,$GeV) up to the PeV region, covering large ground surface areas (few square km).

31. The search for high altitude sites in South America for the SWGO detector

Author

Doro, M., Marques Moraes, A., Santander, M., Giammarchi, M., Mandat, D., Mendes, L. M., Bellido, J., Dib, C. O., May, S., Reisenegger, A., Rovero, A. C., Sandoval, A., Schussler, F., Springer, R. W., Torres, I., Vicha, J., Abreu, P., Albert, A., Angüner, E. O., Arcaro, C., Arnaldi, L. H., Arteaga-Velázquez, J. C., Assis, P., Bakalová, A., Barres Almeida, U., Batković, I., Belmont-Moreno, E., Bisconti, F., Blanco, A., Bohacova, M., Bottacini, E., Bretz, T., Brisbois, C., Brogueira, P., Brown, A. M., Bulik, T., Caballero Mora, K. S., Campos, S. M., Chiavassa, A., Chytka, L., Ruben Conceição, Consolati, G., Cotzomi Paleta, J., Dasso, S., Angelis, A., Bom, C. R., La Fuente, E., Souza, V., Depaoli, D., Di Sciascio, G., Dorner, D., Du Vernois, M., Ergin, T., Fan, K. L., Fraija, N., Funk, S., García, J. I., García-González, J. A., García Roca, S. T., Giacinti, G., Goksu, H., González, B. S., Guarino, F., Guillén, A., Haist, F., Hansen, P. M., Harding, J. P., Hinton, J., Hofmann, W., Hona, B., Hoyos, D., Huentemeyer, P., Hueyotl-Zahuantitla, F., Insolia, A., Janecek, P., Joshi, V., Khelifi, B., Kunwar, S., La Mura, G., Lapington, J., Laspiur, M. R., Leitl, F., Longo, F., Lopes, L., Lopez-Coto, R., Mariazzi, A. G., Mariotti, M., Martínez-Castro, J., Martínez-Huerta, H., Melo, D. G., Mendes, L. F., Mineeva, T., Mitchell, A., Mohan, S., Morales Olivares, O. G., Moreno-Barbosa, E., Nellen, L., Novotny, V., Olivera-Nieto, L., Orlando, E., Pech, M., Pichel, A., Pimenta, M., Portes Albuquerque, M., Prandini, E., Rado Cuchills, M. S., Reville, B., Rho, C. D., Ruiz-Velasco, E., Salazar, G. A., Schoorlemmer, H., Schüssler, F., Serrano, V. H., Shellard, R. C., Sinha, A., Smith, A. J., Surajbali, P., Tomé, B., Torres Aguilar, I., Eldik, C., Vergara-Quispe, I. D., Viana, A., Vícha, J., Vigorito, C. F., Wang, X., Werner, F., White, R., and Zamalloa Jara, M. A.

Subjects
Current (stream), Altitude, Air shower, Observatory, Front (oceanography), Environmental science, Effects of high altitude on humans, Southern Hemisphere, Cherenkov radiation, Remote sensing
Abstract

The Southern Wide-field Gamma-ray Observatory (SWGO) is a project for a new generation of extensive air shower front detectors, based primarily on the water Cherenkov technique, to be located in the Southern Hemisphere, where no other instrument of that kind is currently operating in the TeV gamma-ray energy range. The reference configuration of SWGO foresees an array of about 6,000 water Cherenkov tanks deployed over a circle of 320 m diameter, about 80,000 m$^2$ area. In order to reach a sensitivity at energies around and below 1 TeV competitive with current and future detectors, SWGO will be placed at altitude above 4,400 m a.s.l. Preliminary site searches have found several candidate sites in Argentina, Bolivia, Chile and Peru. The major challenge will be the water provision, considering that at least 10$^5$ m$^3$ of water will be required. This poster will present the challenges and status of the SWGO site search in South America.

32. AEROSITE: Autonomous Environmental and Scientific SWGO site Characterization Instrument

Author

Chytka, L., Mandát, D., Pech, M., Staník, D., Vícha, J., Trávníček, P., Boháčová, M., Tobiška, P., Bulik, T., Cieślar, M., Suchenek, M., Abreu, P., Albert, A., Angüner, E. O., Arcaro, C., Arnaldi, L. H., Arteaga-Velázquez, J. C., Assis, P., Bakalová, A., Barres Almeida, U., Batković, I., Bellido, J., Belmont-Moreno, E., Bisconti, F., Blanco, A., Bottacini, E., Bretz, T., Brisbois, C., Brogueira, P., Brown, A. M., Caballero Mora, K. S., Campos, S. M., Chiavassa, A., Ruben Conceição, Consolati, G., Cotzomi Paleta, J., Dasso, S., Angelis, A., Bom, C. R., La Fuente, E., Souza, V., Depaoli, D., Di Sciascio, G., Dib, C. O., Dorner, D., Doro, M., Du Vernois, M., Ergin, T., Fan, K. L., Fraija, N., Funk, S., García, J. I., García-González, J. A., García Roca, S. T., Giacinti, G., Goksu, H., González, B. S., Guarino, F., Guillén, A., Haist, F., Hansen, P. M., Harding, J. P., Hinton, J., Hofmann, W., Hona, B., Hoyos, D., Huentemeyer, P., Hueyotl-Zahuantitla, F., Insolia, A., Janecek, P., Joshi, V., Khelifi, B., Kunwar, S., La Mura, G., Lapington, J., Laspiur, M. R., Leitl, F., Longo, F., Lopes, L., Lopez-Coto, R., Mariazzi, A. G., Mariotti, M., Marques Moraes, A., Martínez-Castro, J., Martínez-Huerta, H., May, S., Melo, D. G., Mendes, L. F., Mendes, L. M., Mineeva, T., Mitchell, A., Mohan, S., Morales Olivares, O. G., Moreno-Barbosa, E., Nellen, L., Novotny, V., Olivera-Nieto, L., Orlando, E., Pichel, A., Pimenta, M., Portes Albuquerque, M., Prandini, E., Rado Cuchills, M. S., Reisenegger, A., Reville, B., Rho, C. D., Rovero, A. C., Ruiz-Velasco, E., Salazar, G. A., Sandoval, A., Santander, M., Schoorlemmer, H., Schüssler, F., Serrano, V. H., Shellard, R. C., Sinha, A., Smith, A. J., Surajbali, P., Tomé, B., Torres Aguilar, I., Eldik, C., Vergara-Quispe, I. D., Viana, A., Vigorito, C. F., Wang, X., Werner, F., White, R., and Zamalloa Jara, M. A.

33. Prolactinoma: a condition associated with hypoadiponectinemia.

Author

de Assunção Alves Rodrigues LF, Campos SM, Miranda PA, Bizzi MF, Sales do Amaral PH, Giannetti AV, and Ribeiro-Oliveira A

Subjects
Adiponectin blood, Adiponectin deficiency, Adult, Blood Glucose analysis, Case-Control Studies, Cholesterol, HDL blood, Female, Humans, Insulin blood, Insulin Resistance, Male, Metabolism, Inborn Errors blood, Pituitary Neoplasms blood, Prolactinoma blood, Triglycerides blood, Metabolism, Inborn Errors etiology, Pituitary Neoplasms complications, Prolactinoma complications
Abstract

Prolactinomas are prolactin-secreting neoplasias accounting for 40% of the pituitary adenomas. Much is known about the effects of prolactinomas on the reproductive system, but few data are yet available regarding their induced changes on metabolism. This study was aimed at evaluating patients with prolactinomas for insulin resistance and adiponectinemia. Forty patients with prolactinoma were allocated to 2 different groups according to disease control: 20 with uncontrolled disease (UPRL) and 20 with controlled disease in the last 6 months (CPRL). Forty healthy individuals (CG) matched for age, sex, and body mass index were taken as controls. Patients with prolactinoma were compared both as a one group and according to disease control with CG. All subjects were evaluated for waist/hip ratio (WHR), blood pressure, lipid profile, fasting glucose, homeostasis assessment model of insulin resistance (HOMAIR), and adiponectin. Patients with prolactinomas (UPRL+CPRL) showed higher insulin (p<0.05) and HOMAIR (p<0.05), alongside with lower adiponectin levels (p<0.01) than matched controls. When UPRL was compared to CPRL and CG, UPRL was disclosed as a subgroup of significant altered metabolic profile as related to WHR (p<0.01 for comparisons), high-density lipoprotein cholesterol (p<0.05 for comparisons), triglycerides (p<0.05 for comparisons), HOMAIR (p<0.05 and p<0.01, respectively), and adiponectin (p<0.01 for comparisons). All these metabolic abnormalities, except hypoadiponectinemia (p<0.01), were not observed in CPRL. These data suggest that prolactinomas are associated with hypoadiponectinemia, which is further exacerbated in uncontrolled patients when insulin resistance is also prominent., (© Georg Thieme Verlag KG Stuttgart · New York.)

Published
2012
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34. A phase II study of fixed dose rate gemcitabine in patients with relapsed müllerian tumors.

Author

Penson RT, Campos SM, Seiden MV, Krasner C, Fuller AF Jr, Goodman A, Roche M, Willman A, Muzikansky A, and Matulonis UA

Subjects
Adult, Aged, Antineoplastic Agents therapeutic use, Carboplatin therapeutic use, Deoxycytidine administration & dosage, Disease Progression, Dose-Response Relationship, Drug, Drug Resistance, Neoplasm, Female, Humans, Middle Aged, Treatment Outcome, Gemcitabine, Adenocarcinoma drug therapy, Antineoplastic Agents administration & dosage, Deoxycytidine analogs & derivatives, Genital Neoplasms, Female drug therapy, Neoplasm Recurrence, Local drug therapy
Abstract

Gemcitabine (2',2'-difluorodeoxycytidine) is a novel purine analog with clinical activity against ovarian cancer. Accumulation of gemcitabine triphosphate (dFdCTP) increases in a linear fashion with prolonged infusions of gemcitabine, and there is a strong relationship between intracellular accumulation of dFdCTP and DNA damage. Women with ovarian, fallopian tube, or primary peritoneal carcinoma and documented recurrent disease were eligible for the study. Patients could not have received more than four prior lines of chemotherapy and had to have measurable or evaluable disease. Gemcitabine 800 mg/m2 administered by intravenous infusion at 10 mg/m2/min (fixed dose rate [FDR]) on days 1 and 8 of a 21-day schedule. Twenty-eight patients with a median age 60 (range, 40-77) years were treated. Although 43% were Eastern Cooperative Oncology Group 0, 50% had liver metastases. Eighty-eight cycles of therapy were delivered (median 2 [range, 1-6]). Five of the first ten patients treated at 800 mg/m2 could not receive day 8 FDR-gemcitabine because of neutropenia, and the starting dose was reduced to 700 mg/m2. Even at this dose there was cumulative hematologic toxicity resulting in dose reductions. Vomiting, mucositis, diarrhea, allergy, rash, fever, and alopecia were mild. In 28 patients, there was only one partial response (4%, 95% CI 0-18%) and median time to progression was 1.7 (interquartile range, 1.2-3.9) months. FDR-gemcitabine 700 mg/m2 administered by intravenous infusion at an FDR of 10 mg/m2/min had minimal activity against heavily pretreated recurrent tumors of müllerian origin. The optimal dose and schedule of gemcitabine is yet to be defined in this population.

Published
2005
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35. Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer.

Author

Burstein HJ, Kuter I, Campos SM, Gelman RS, Tribou L, Parker LM, Manola J, Younger J, Matulonis U, Bunnell CA, Partridge AH, Richardson PG, Clarke K, Shulman LN, and Winer EP

Subjects
Adult, Aged, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols adverse effects, Breast Neoplasms pathology, Cardiomyopathies chemically induced, Chemotherapy, Adjuvant, Female, Humans, Middle Aged, Neoplasm Metastasis, Trastuzumab, Treatment Outcome, Vinblastine administration & dosage, Vinorelbine, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Breast Neoplasms drug therapy, Breast Neoplasms genetics, Receptor, ErbB-2 genetics, Vinblastine analogs & derivatives
Abstract

Purpose: To determine the response rate and toxicity profile of trastuzumab administered concurrently with weekly vinorelbine in women with HER2-overexpressing advanced breast cancer., Patients and Methods: Forty women with HER2-positive (+3 by immunohistochemistry, n = 30; +2 or positive, n = 10) breast cancer were enrolled onto a study of trastuzumab (4 mg/kg x 1, 2 mg/kg weekly thereafter) and vinorelbine (25 mg/m2 weekly, with dose adjusted each week for neutrophil count). Eighty-two percent of women had received prior chemotherapy as part of adjuvant (30%), metastatic (25%), or both (28%) treatment, including substantial portions of patients who had previously received either anthracyclines (20%), taxanes (15%), or both types (38%) of chemotherapy., Results: Responses were observed in 30 of 40 patients (overall response rate, 75%, conditional corrected 95% confidence interval, 57% to 89%). The response rate was 84% in patients treated with trastuzumab and vinorelbine as first-line therapy for metastatic disease, and 80% among HER2 +3 positive patients. High response rates were also seen in women treated with second- or third-line therapy, and among patients previously treated with anthracyclines and/or taxanes. Combination therapy was feasible; patients received concurrent trastuzumab and vinorelbine in 93% of treatment weeks. Neutropenia was the only grade 4 toxicity. No patients had symptomatic heart failure. Grade 2 cardiac toxicity was observed in three patients. Prior cumulative doxorubicin dose in excess of 240 mg/m2 and borderline pre-existing cardiac function were associated with grade 2 cardiac toxicity., Conclusion: Trastuzumab in combination with vinorelbine is highly active in women with HER2-overexpressing advanced breast cancer and is well tolerated.

Published
2001
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36. The clinical utility of liposomal doxorubicin in recurrent ovarian cancer.

Author

Campos SM, Penson RT, Mays AR, Berkowitz RS, Fuller AF, Goodman A, Matulonis UA, Muzikansky A, and Seiden MV

Subjects
Adult, Aged, Antibiotics, Antineoplastic adverse effects, Doxorubicin adverse effects, Female, Humans, Liposomes, Middle Aged, Neoplasm Recurrence, Local drug therapy, Neoplasm Recurrence, Local metabolism, Ovarian Neoplasms metabolism, Receptor, ErbB-2 biosynthesis, Retrospective Studies, Antibiotics, Antineoplastic administration & dosage, Doxorubicin administration & dosage, Ovarian Neoplasms drug therapy
Abstract

Objectives: The aim of this study was to determine the efficacy and toxicity of single agent off-protocol, liposomal doxorubicin (Doxil Alza), in consecutive patients with recurrent ovarian cancer and to investigate the influence of HER-2/neu expression on response to liposomal doxorubicin., Patients and Methods: Retrospective analysis of 72 consecutive patients treated, typically with liposomal doxorubicin 40 mg/m(2) q28 days between January 1997 and December 1998. Results. Twenty-nine patients (40%) had platinum- and taxane-resistant tumors. Nineteen patients (27%) responded with clinical or radiological evidence of response with reduction in CA-125 of >50%. One complete response (CR) and 7 partial responses (PRs) occurred in platinum- and taxane-resistant patients (radiological response (RR) 29%) and 8 PRs occurred in patients with visceral metastases (RR 28%). Time to progression was 5.3 (2.1-12.1) months. Only 7 dose delays (3%) and 20 dose reductions (8%) were necessary in 265 cycles of treatment. Hematological toxicity was generally mild with grade (Gr) > or =III neutropenia in 1 (2%), Gr > or =III thrombocytopenia in 1 (1%), and Gr > or =III anemia in 8 patients (11%). One patient (1%) was admitted with fever and neutropenia. Other toxicity was minimal with Gr > or =III mucositis occurring in 3 patients (4%). Gr > or =III cutaneous toxicity was seen in 6 patients (8%). Three patients (4%) had a >10% fall in ejection fraction but there was no unequivocal clinical heart failure., Conclusions: The data suggest that liposomal doxorubicin is an active drug in both taxane- and platinum-sensitive and resistant recurrent ovarian cancer. Liposomal doxorubicin is associated with tolerable toxicity and is particularly well tolerated in patients with multiple prior lines of treatment., (Copyright 2001 Academic Press.)

Published
2001
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38. Effect of polishing burs and stones on the micro-hardness of dental amalgam.

Author

Ribeiro SA, do Nascimento TN, Centola AL, Teixeira LC, and Campos SM

Subjects
Analysis of Variance, Dental Restoration, Permanent, Hardness, Humans, Dental Amalgam chemistry, Dental Polishing instrumentation
Abstract

Square standard cavities were prepared in human teeth and restored with amalgam obtained from alloys of different trade-marks. Twenty-four hours after condensation, excess amalgam was removed from three of the four margins, each with a different rotatory instrument (number 4 bur, multiblade finishing bur, and fine green stone). No rotatory instrument was used on the fourth margin (control), and this control was polished with pumice and zinc-oxide pastes and Sweeney's brushes. Vickers' tests for micro-hardness of the amalgam were performed on the four margins of the restorations. The restorations were then submitted to metallographic polishing, and a second micro-hardness measurement was made seven days later. The statistical analysis of the data showed that micro-hardness values were higher at the margins on which no rotatory instruments were used. The lowest micro-hardness values were found at the margins where finishing and/or round burs were used. Polishing with fine green stones gave intermediate values.

Published
1992

39. Study of mandibular head volume in rats submitted to occlusal alterations.

Author

Campos MN, Campos SM, Angerami JR, and Pagnano VO

Subjects
Analysis of Variance, Animals, Dental Occlusion, Traumatic etiology, Jaw, Edentulous, Partially physiopathology, Male, Mandibular Condyle pathology, Rats, Rats, Inbred Strains, Dental Occlusion, Traumatic physiopathology, Jaw, Edentulous, Partially complications, Mandibular Condyle growth & development
Abstract

The possible alterations caused by occlusal modifications in mandibular head volume were studied in rats by morphometric techniques. The results permitted the authors to conclude that, within the conditions of the experiments, the total volume of the mandibular head was unchanged, although alterations in the direction of growth may occur.

Published
1991

44. [Gastric lipoma. Presentation of 2 cases].

Author

Safatle NF, Campos SM, de Almeida MC, Costacurta MA, and França LC

Subjects
Adult, Female, Humans, Lipoma diagnostic imaging, Male, Middle Aged, Radiography, Stomach Neoplasms diagnostic imaging, Lipoma pathology, Stomach Neoplasms pathology
Published
1980

45. [Microhardness of margins of amalgam restorations].

Author

Centola Al, Ribeiro SA, Campos SM, Campos GM, and Nonaka T

Subjects
Dental Alloys, Dental High-Speed Equipment, Dental Leakage prevention & control, Dental Polishing, Hardness, Humans, Surface Properties, Dental Amalgam
Published
1988

49. [PANCREATIC HYPOGLYCEMIA].

Author

BOVE P, DE OLIVEIRA MR, SPERANZINI MB, FUJIMURA I, and CAMPOS SM

Subjects
Humans, Adenoma, Islet Cell, Calculi, Hypoglycemia, Neurologic Manifestations, Pancreas, Pancreatic Ducts, Pancreatic Neoplasms, Surgical Procedures, Operative
Published
1963

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