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4. Non-T depleted haploidentical stem cell transplantation in AML patients achieving first complete remission after one versus two induction courses: a study from the ALWP/EBMT

Author

Nagler, Arnon, Labopin, Myriam, Huang, Xiao-jun, Blaise, Didier, Arcese, William, Araujo, Mercedes Colorado, Socié, Gerard, Forcade, Edouard, Ciceri, Fabio, Canaani, Jonathan, Giebel, Sebastian, Brissot, Eolia, Caballer, Jaime Sanz, Bazarbachi, Ali, Yakoub-Agha, Ibrahim, and Mohty, Mohamad

Published
2022
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8. Acute Myeloid Leukemia in Adults

Author

Versluis, Jurjen, Cornelissen, Jan J., Craddock, Charles, Sanz, Miguel Á., Canaani, Jonathan, Nagler, Arnon, Carreras, Enric, editor, Dufour, Carlo, editor, Mohty, Mohamad, editor, and Kröger, Nicolaus, editor

Published
2019
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9. Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Nagler, Arnon, Labopin, Myriam, Houhou, Mohamed, Aljurf, Mahmoud, Mousavi, Ashrafsadat, Hamladji, Rose-Marie, Al Zahrani, Mohsen, Bondarenko, Sergey, Arat, Mutlu, Angelucci, Emanuele, Koc, Yener, Gülbas, Zafer, Sica, Simona, Bourhis, Jean Henri, Canaani, Jonathan, Brissot, Eolia, Giebel, Sebastian, and Mohty, Mohamad

Published
2021
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11. Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients Age >69 Years with Acute Myelogenous Leukemia: On Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Ringdén, Olle, Boumendil, Ariane, Labopin, Myriam, Canaani, Jonathan, Beelen, Dietrich, Ehninger, Gerhard, Niederwieser, Dietger, Finke, Jurgen, Stelljes, Matthias, Gerbitz, Armin, Ganser, Arnold, Kröger, Nicolaus, Kantz, Lothar, Brecht, Arne, Savani, Bipin, Sadeghi, Behnam, Mohty, Mohamad, and Nagler, Arnon

Published
2019
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15. Impact of Cytogenetic Risk on Outcomes of Non-T-Cell–Depleted Haploidentical Hematopoietic Cell Transplantation in Patients with Relapsed or Refractory Acute Myeloid Leukemia

Author

Nagler, Arnon, Labopin, Myriam, Dholaria, Bhagirathbhai, Ciceri, Fabio, Fraccaroli, Alessia, Blaise, Didier, Fanin, Renato, Bruno, Benedetto, Forcade, Edouard, Vydra, Jan, Chevallier, Patrice, Bulabois, Claude Eric, Jindra, Pavel, Bornhäuser, Martin, Canaani, Jonathan, Sanz, Jaime, Savani, Bipin N., Spyridonidis, Alexandros, Giebel, Sebastian, Brissot, Eolia, Bazarbachi, Ali, Esteve, Jordi, and Mohty, Mohamad

Published
2022
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16. Venetoclax‐based salvage therapy for adult patients with relapsed/refractory acute lymphoblastic leukemia

Author

Canaani, Jonathan, primary, Frisch, Avraham, additional, Pollyea, Daniel A., additional, Schwartz, Marc, additional, Aumann, Shlomzion, additional, Ganzel, Chezi, additional, Haran, Arnon, additional, Even‐Zohar, Noa Gross, additional, Shaulov, Adir, additional, Vainstein, Vladimir, additional, Moshe, Yakir, additional, Ofran, Yishai, additional, Wolach, Ofir, additional, and Nachmias, Boaz, additional

Published
2023
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17. Graft-versus-Host Disease Prophylaxis with Post-Transplantation Cyclophosphamide versus Cyclosporine A and Methotrexate in Matched Sibling Donor Transplantation

Author

Nagler, Arnon, Labopin, Myriam, Dholaria, Bhagirathbhai, Wu, Depei, Choi, Goda, Aljurf, Mahmoud, Ciceri, Fabio, Gedde-Dahl, Tobias, Meijer, Ellen, Niittyvuopio, Riitta, Bondarenko, Sergey, Bourhis, Jean Henri, Cornelissen, Jan J., Socié, Gerard, Koc, Yener, Canaani, Jonathan, Savani, Bipin, Bug, Gesine, Spyridonidis, Alexandros, Giebel, Sebastian, Brissot, Eolia, Bazarbachi, Ali, Esteve, Jordi, and Mohty, Mohamad

Published
2022
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18. Comparable results of autologous and allogeneic haematopoietic stem cell transplantation for adults with Philadelphia-positive acute lymphoblastic leukaemia in first complete molecular remission: An analysis by the Acute Leukemia Working Party of the EBMT

Author

Giebel, Sebastian, Labopin, Myriam, Potter, Michael, Poiré, Xavier, Sengeloev, Henrik, Socié, Gerard, Huynh, Anne, Afanasyev, Boris V., Schanz, Urs, Ringden, Olle, Kalhs, Peter, Beelen, Dietrich W., Campos, Antonio M., Masszi, Tamás, Canaani, Jonathan, Mohty, Mohamad, and Nagler, Arnon

Published
2018
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20. Data from Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia

Author

McMahon, Christine M., primary, Ferng, Timothy, primary, Canaani, Jonathan, primary, Wang, Eunice S., primary, Morrissette, Jennifer J.D., primary, Eastburn, Dennis J., primary, Pellegrino, Maurizio, primary, Durruthy-Durruthy, Robert, primary, Watt, Christopher D., primary, Asthana, Saurabh, primary, Lasater, Elisabeth A., primary, DeFilippis, RosaAnna, primary, Peretz, Cheryl A.C., primary, McGary, Lisa H.F., primary, Deihimi, Safoora, primary, Logan, Aaron C., primary, Luger, Selina M., primary, Shah, Neil P., primary, Carroll, Martin, primary, Smith, Catherine C., primary, and Perl, Alexander E., primary

Published
2023
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21. Supplementary Figures from Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia

Author

McMahon, Christine M., primary, Ferng, Timothy, primary, Canaani, Jonathan, primary, Wang, Eunice S., primary, Morrissette, Jennifer J.D., primary, Eastburn, Dennis J., primary, Pellegrino, Maurizio, primary, Durruthy-Durruthy, Robert, primary, Watt, Christopher D., primary, Asthana, Saurabh, primary, Lasater, Elisabeth A., primary, DeFilippis, RosaAnna, primary, Peretz, Cheryl A.C., primary, McGary, Lisa H.F., primary, Deihimi, Safoora, primary, Logan, Aaron C., primary, Luger, Selina M., primary, Shah, Neil P., primary, Carroll, Martin, primary, Smith, Catherine C., primary, and Perl, Alexander E., primary

Published
2023
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22. Supplementary Tables from Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia

Author

McMahon, Christine M., primary, Ferng, Timothy, primary, Canaani, Jonathan, primary, Wang, Eunice S., primary, Morrissette, Jennifer J.D., primary, Eastburn, Dennis J., primary, Pellegrino, Maurizio, primary, Durruthy-Durruthy, Robert, primary, Watt, Christopher D., primary, Asthana, Saurabh, primary, Lasater, Elisabeth A., primary, DeFilippis, RosaAnna, primary, Peretz, Cheryl A.C., primary, McGary, Lisa H.F., primary, Deihimi, Safoora, primary, Logan, Aaron C., primary, Luger, Selina M., primary, Shah, Neil P., primary, Carroll, Martin, primary, Smith, Catherine C., primary, and Perl, Alexander E., primary

Published
2023
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24. Defining Current Patterns of Blood Product Use during Intensive Induction Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia Patients.

Author

Miller, Liron, Freed-Freundlich, Mor, Shimoni, Avichai, Hellou, Tamer, Avigdor, Abraham, Misgav, Mudi, and Canaani, Jonathan

Abstract

Introduction: Blood product transfusion retains a critical role in the supportive care of patients with acute myeloid leukemia (AML). Whereas previous studies have shown increased transfusion dependency to portend inferior outcome, predictive factors of an increased transfusion burden and the prognostic impact of transfusion support have not been assessed recently. Methods/Patients: We performed a retrospective analysis on a recent cohort of patients given intensive induction chemotherapy in 2014–2022. Results: The analysis comprised 180 patients with a median age of 57 years with 80% designated as de novo AML. Fifty-four patients (31%) were FLT3-ITD mutated, and 73 patients (42%) harbored NPM1. Favorable risk and intermediate risk ELN 2017 patients accounted for 43% and 34% of patients, respectively. The median number of red blood cell (RBC) and platelet units given during induction were 9 and 7 units, respectively. Seventeen patients (9%) received cryoprecipitate, and fresh frozen plasma (FFP) was given to 12 patients (7%). Lower initial hemoglobin and platelet levels were predictive of increased use of RBC (p < 0.0001) and platelet transfusions (p < 0.0001). FFP was significantly associated with induction related mortality (42% vs. 5%; p < 0.0001) and with FLT3-ITD (72% vs. 28%; p = 0.004). Blood group AB experienced improved mean overall survival compared to blood group O patients (4.1 years vs. 2.8 years; p = 0.025). In multivariate analysis, increased number of FFP (hazard ratio [HR], 4.23; 95% confidence interval [CI], 2.1–8.6; p < 0.001) and RBC units (HR, 1.8; 95% CI, 1.2–2.8; p = 0.008) given was associated with inferior survival. Conclusion: Transfusion needs during induction crucially impact the clinical trajectory of AML patients. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Acute Myeloid Leukemia in Adults

Author

Versluis, Jurjen, primary, Cornelissen, Jan J., additional, Craddock, Charles, additional, Sanz, Miguel Á., additional, Canaani, Jonathan, additional, and Nagler, Arnon, additional

Published
2018
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28. Utilization of Antifungal Prophylaxis and Treatment for Newly Diagnosed AML Patients Treated with Venetoclax Based Regimens in Routine Clinical Practice - a Prospective Analysis from the Revive Study

Author

Stemer, Galia, primary, Wolach, Ofir, additional, Levi, Itai, additional, Nachmias, Boaz, additional, Tavor, Sigal, additional, Canaani, Jonathan, additional, Ofran, Yishai, additional, Ganzel, Chezi, additional, Zuckerman, Tsila, additional, Okasha, Doaa, additional, Hellmann, Ilana, additional, Tadmor, Tamar, additional, Dally, Najib, additional, Cohen, Raanan, additional, Berelovich, Jenia, additional, Ofek, Keren, additional, Rivlin, Noa, additional, Frankel, Neta, additional, Grunspan, Moshe, additional, and Moshe, Yakir, additional

Published
2022
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29. Interim Results from Clevo: A Non-Interventional Cohort Study Investigating the Clonal Evolution of FMS-like Tyrosine Kinase 3 (FLT3) Mutations during Disease Progression in Patients with Acute Myeloid Leukemia

Author

Papayannidis, Cristina, primary, Boluda, Blanca, additional, Canaani, Jonathan, additional, Turlure, Pascal, additional, De Becker, Ann, additional, Tandra, Anand, additional, Elsouda, Dina, additional, Houweling, Arnaud, additional, Upadhyay, Anil, additional, Wouters, Isabelle, additional, and Vyas, Paresh, additional

Published
2022
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32. Clinical Predictors for Relapse Among Patients with AML Who Responded to Venetoclax-Based Treatment - a Real-World Prospective Analysis from the Revive Study Group

Author

Ganzel, Chezi, primary, Moshe, Yakir, additional, Levi, Itai, additional, Nachmias, Boaz, additional, Tavor, Sigal, additional, Canaani, Jonathan, additional, Zuckerman, Tsila, additional, Okasha, Doaa, additional, Hellmann, Ilana, additional, Tadmor, Tamar, additional, Dally, Najib, additional, Stemer, Galia, additional, Cohen, Raanan, additional, Berelovich, Jenia, additional, Rivlin, Noa, additional, Frankel, Neta, additional, Grunspan, Moshe, additional, Ofek, Keren, additional, Ofran, Yishai, additional, and Wolach, Ofir, additional

Published
2022
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36. Thiotepa‐based conditioning versus total body irradiation as myeloablative conditioning prior to allogeneic stem cell transplantation for acute lymphoblastic leukemia: A matched‐pair analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Eder, Sandra, Canaani, Jonathan, Beohou, Eric, Labopin, Myriam, Sanz, Jaime, Arcese, William, Or, Reuven, Finke, Juergen, Cortelezzi, Agostino, Beelen, Dietrich, Passweg, Jakob, Socié, Gerard, Gurman, Gunhan, Aljurf, Mahmoud, Stelljes, Matthias, Giebel, Sebastian, Mohty, Mohamad, and Nagler, Arnon

Published
2017
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39. Cytogenetic risk classification maintains its prognostic significance in transplanted FLT3-ITD mutated acute myeloid leukemia patients: On behalf of the acute leukemia working party/European society of blood and marrow transplantation

Author

Nagler, Arnon, Labopin, Myriam, Craddock, Charles, Socié, Gerard, Yakoub-Agha, Ibrahim, Gedde-Dahl, Tobias, Niittyvuopio, Riitta, Byrne, Jennifer Louise, Cornelissen, Jan J., Labussière-Wallet, Hélène, Arcese, William, Milpied, Noel, Esteve, Jordi, Canaani, Jonathan, Mohty, Mohamad, and Hematology

Abstract

FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutational status is a pivotal prognosticator in acute myeloid leukemia (AML) patients and significantly increases the risk of disease relapse. However, it remains unclear whether in FLT3-ITD patients referred for allogeneic stem cell transplantation (allo-SCT), baseline cytogenetics significantly impacts clinical outcome. Using the European Society of Blood and Marrow Transplantation registry, we performed a retrospective analysis of 1631 FLT3-ITD AML patients who underwent allo-SCT with the aim of determining the influence of cytogenetic risk category on patient outcomes. Median patient age was 49 years and median follow-up duration was 36 months. Two-year leukemia-free survival (LFS) and incidence of relapse were 54% and 31.6%, respectively. Non-relapse mortality was experienced by 14.4% with a 2-year overall survival (OS) of 60.1%. On multivariate analysis, LFS was significantly lower in patients with intermediate and adverse risk cytogenetics compared with those with favorable risk cytogenetics, (hazard ratio [HR] = 1.48, 95% confidence interval [CI], 1.06–2.06; p =.02), and (HR = 01.65, 95% CI, 1.13–2.40; p =.009), respectively. OS was significantly lower in patients with adverse risk cytogenetics compared with patients with favorable risk cytogenetics (HR = 1.74, 95% CI, 1.16–2.61; p =.008) with a trend toward lower OS in patients with intermediate risk cytogenetics compared to those with favorable risk cytogenetics (HR = 1.43, 95% CI, 1.00–2.05; p =.052). In addition, adverse risk patients and intermediate risk patients experienced higher relapse rates compared with favorable risk patients (HR = 1.83, 95% CI, 1.13–2.94; p =.013 and HR = 1.82, 95% CI, 1.19–2.77; p =.005). Overall, cytogenetic studies aid in refinement of risk stratification in transplanted FLT3-ITD AML patients.

Published
2022

43. Cytogenetic risk classification maintains its prognostic significance in transplanted FLT3‐ITD mutated acute myeloid leukemia patients: On behalf of the acute leukemia working party / European society of blood and marrow transplantation

Author

Nagler, Arnon, primary, Labopin, Myriam, additional, Craddock, Charles, additional, Socié, Gerard, additional, Yakoub‐Agha, Ibrahim, additional, Gedde‐Dahl, Tobias, additional, Niittyvuopio, Riitta, additional, Byrne, Jennifer Louise, additional, Cornelissen, Jan J., additional, Labussière‐Wallet, Hélène, additional, Arcese, William, additional, Milpied, Noel, additional, Esteve, Jordi, additional, Canaani, Jonathan, additional, and Mohty, Mohamad, additional

Published
2022
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46. Real World Prospective Observational Multicenter Trial of Venetoclax-Based Therapy for Patients with AML Reveals Unique Patterns of Patient Selection and Treatment Utilization - Revive Study

Author

Wolach, Ofir, primary, Levi, Itai, additional, Lavie, David, additional, Canaani, Jonathan, additional, Tavor, Sigal, additional, Hellmann, Ilana, additional, Tadmor, Tamar, additional, Zuckerman, Tsila, additional, Stemer, Galia, additional, Berelovich, Jenia, additional, Ofek, Keren, additional, Frankel, Neta, additional, Grunspan, Moshe, additional, Ofran, Yishai, additional, and Moshe, Yakir, additional

Published
2021
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48. GVHD Prophylaxis With Post Transplantation Cyclophosphamide (PTCY) Versus Cyclosporine A / Methotrexate Post Allogeneic Transplantation (HSCT) From Matched Siblings For AML: From The ALWP/EBMT

Author

Nagler, Arnon, Labopin, Myriam, Wu, Depei, Choi, Goda, Aljurf, Mahmoud, Ciceri, Fabio, Gedde-Dahl, Tobias, Meijer, Ellen, Niittyvuopio, Riitta, Moiseev, Ivan, Bourhis, Jean Henri, Cornelissen, Jan. J., Socie, Gerard, Koc, Yener, Canaani, Jonathan, Savani, Bipin, Bug, Gesine, Spyridonidis, Alexandros, Giebel, Sebastian, Brissot, Eolia, Bazarbachi, Ali, Esteve, Jordi, and Mohty, Mohamd

Published
2021

49. 32 - Non T–Cell Depleted Haploidentical Versus Matched Sibling Donor Hematopoietic Stem Cell Transplantation in Adult Patients with Acute Lymphoblastic Leukemia in Remission: A Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Nagler, Arnon, Labopin, Myriam, Houhou, Mohamed, Aljurf, Mahmoud Deeb, Mousavi, Ashrafsadat, Hamladji, Rose-Marie, Alzahrani, Mohsen, Bondarenko, Sergey N., Arat, Mutlu, Angelucci, Emanuele, Koc, Yener, Gülbas, Zafer, Sica, Simona, Bourhis, Jean Henri, Canaani, Jonathan, Brissot, Eolia, Giebel, Sebastian, and Mohty, Mohamad

Published
2021
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50. Additional file 2 of Outcome of haploidentical versus matched sibling donors in hematopoietic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Nagler, Arnon, Labopin, Myriam, Houhou, Mohamed, Aljurf, Mahmoud, Ashrafsadat Mousavi, Rose-Marie Hamladji, Zahrani, Mohsen Al, Bondarenko, Sergey, Arat, Mutlu, Angelucci, Emanuele, Koc, Yener, Gülbas, Zafer, Sica, Simona, Bourhis, Jean Henri, Canaani, Jonathan, Eolia Brissot, Giebel, Sebastian, and Mohty, Mohamad

Subjects
InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES, ComputerApplications_COMPUTERSINOTHERSYSTEMS
Abstract

Additional file 2: Supplementary tables.

Published
2021
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