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2 results on '"Canaria Park"'

1. Small RNA sequencing of circulating small extracellular vesicles microRNAs in patients with amyotrophic lateral sclerosis

Author

Jin-Ah Kim, Canaria Park, Jung-Joon Sung, Do-Jin Seo, Seok-Jin Choi, and Yoon-Ho Hong

Subjects
Medicine, Science
Abstract

Abstract Dysregulation of microRNAs (miRNA) in small extracellular vesicles (sEV) such as exosomes have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Although circulating cell-free miRNA have been extensively investigated in ALS, sEV-derived miRNAs have not been systemically explored yet. Here, we performed small RNA sequencing analysis of serum sEV and identified 5 differentially expressed miRNA in a discovery cohort of 12 patients and 11 age- and sex-matched healthy controls (fold change > 2, p

Published
2023
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2. B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients with Myasthenia Gravis

Author

Je Young Shin, Yoon-Ho Hong, Jung-Joon Sung, Young Gi Min, Canaria Park, and Young Nam Kwon

Subjects
0301 basic medicine, CD19, Flow cytometry, Transcriptome, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Immunophenotyping, B-lymphocytes, Medicine, Distribution (pharmacology), Myasthenia gravis, B cell, biology, medicine.diagnostic_test, business.industry, Autoantibody, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Immunology, biology.protein, Original Article, Neurology (clinical), business, 030217 neurology & neurosurgery, Biomarkers
Abstract

Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorders mediated by various autoantibodies. Although most patients with MG require chronic immunosuppressive treatment to control disease activity, appropriate surveillance biomarkers that monitor disease activity or potential toxicity of immunosuppressants are yet to be developed. Herein, we investigated quantitative distribution of peripheral blood B cell subsets and transcriptional profiles of memory B cells (CD19+ CD27+) in several subgroups of MG patients classified according to the Myasthenia Gravis Foundation of America (MGFA) Clinical Classification. This study suggests potential immunologic B-cell markers that may guide treatment decision in future clinical settings.

Published
2019

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