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18 results on '"Candrea, Daniel N."'

3. Intracortical Somatosensory Stimulation to Elicit Fingertip Sensations in an Individual With Spinal Cord Injury

Author

Fifer, Matthew S., McMullen, David P., Osborn, Luke E., Thomas, Tessy M., Christie, Breanne, Nickl, Robert W., Candrea, Daniel N., Pohlmeyer, Eric A., Thompson, Margaret C., Anaya, Manuel A., Schellekens, Wouter, Ramsey, Nick F., Bensmaia, Sliman J., Anderson, William S., Wester, Brock A., Crone, Nathan E., Celnik, Pablo A., Cantarero, Gabriela L., and Tenore, Francesco V.

Published
2022
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4. Stable Decoding from a Speech BCI Enables Control for an Individual with ALS without Recalibration for 3 Months

Author

Luo, Shiyu, primary, Angrick, Miguel, additional, Coogan, Christopher, additional, Candrea, Daniel N., additional, Wyse‐Sookoo, Kimberley, additional, Shah, Samyak, additional, Rabbani, Qinwan, additional, Milsap, Griffin W., additional, Weiss, Alexander R., additional, Anderson, William S., additional, Tippett, Donna C., additional, Maragakis, Nicholas J., additional, Clawson, Lora L., additional, Vansteensel, Mariska J., additional, Wester, Brock A., additional, Tenore, Francesco V., additional, Hermansky, Hynek, additional, Fifer, Matthew S., additional, Ramsey, Nick F., additional, and Crone, Nathan E., additional

Published
2023
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5. A click-based electrocorticographic brain-computer interface enables long-term high-performance switch-scan spelling

Author

Candrea, Daniel N., primary, Shah, Samyak, additional, Luo, Shiyu, additional, Angrick, Miguel, additional, Rabbani, Qinwan, additional, Coogan, Christopher, additional, Milsap, Griffin W., additional, Nathan, Kevin C., additional, Wester, Brock A., additional, Anderson, William S., additional, Rosenblatt, Kathryn R., additional, Uchil, Alpa, additional, Clawson, Lora, additional, Maragakis, Nicholas J., additional, Vansteensel, Mariska J., additional, Tenore, Francesco V., additional, Ramsey, Nicolas F., additional, Fifer, Matthew S., additional, and Crone, Nathan E., additional

Published
2023
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6. Online speech synthesis using a chronically implanted brain-computer interface in an individual with ALS

Author

Angrick, Miguel, primary, Luo, Shiyu, additional, Rabbani, Qinwan, additional, Candrea, Daniel N., additional, Shah, Samyak, additional, Milsap, Griffin W., additional, Anderson, William S., additional, Gordon, Chad R., additional, Rosenblatt, Kathryn R., additional, Clawson, Lora, additional, Maragakis, Nicholas, additional, Tenore, Francesco V., additional, Fifer, Matthew S., additional, Hermansky, Hynek, additional, Ramsey, Nick F., additional, and Crone, Nathan E., additional

Published
2023
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7. Intracortical Somatosensory Stimulation to Elicit Fingertip Sensations in an Individual With Spinal Cord Injury

Author

Highfield Research Group, Brain, Projectafdeling functional imaging, Fifer, Matthew S, McMullen, David P, Osborn, Luke E, Thomas, Tessy M, Christie, Breanne, Nickl, Robert W, Candrea, Daniel N, Pohlmeyer, Eric A, Thompson, Margaret C, Anaya, Manuel A, Schellekens, Wouter, Ramsey, Nick F, Bensmaia, Sliman J, Anderson, William S, Wester, Brock A, Crone, Nathan E, Celnik, Pablo A, Cantarero, Gabriela L, Tenore, Francesco V, Highfield Research Group, Brain, Projectafdeling functional imaging, Fifer, Matthew S, McMullen, David P, Osborn, Luke E, Thomas, Tessy M, Christie, Breanne, Nickl, Robert W, Candrea, Daniel N, Pohlmeyer, Eric A, Thompson, Margaret C, Anaya, Manuel A, Schellekens, Wouter, Ramsey, Nick F, Bensmaia, Sliman J, Anderson, William S, Wester, Brock A, Crone, Nathan E, Celnik, Pablo A, Cantarero, Gabriela L, and Tenore, Francesco V

Published
2022

8. Intracortical Somatosensory Stimulation to Elicit Fingertip Sensations in an Individual With Spinal Cord Injury

Author

Fifer, Matthew S., primary, McMullen, David P., additional, Osborn, Luke E., additional, Thomas, Tessy M., additional, Christie, Breanne, additional, Nickl, Robert W., additional, Candrea, Daniel N., additional, Pohlmeyer, Eric A., additional, Thompson, Margaret C., additional, Anaya, Manuel A., additional, Schellekens, Wouter, additional, Ramsey, Nick F., additional, Bensmaia, Sliman J., additional, Anderson, William S., additional, Wester, Brock A., additional, Crone, Nathan E., additional, Celnik, Pablo A., additional, Cantarero, Gabriela L., additional, and Tenore, Francesco V., additional

Published
2021
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9. Novel intraoperative online functional mapping of somatosensory finger representations for targeted stimulating electrode placement: technical note

Author

Projectafdeling functional imaging, Brain, Highfield Research Group, McMullen, David P, Thomas, Tessy M, Fifer, Matthew S, Candrea, Daniel N, Tenore, Francesco V, Nickl, Robert W, Pohlmeyer, Eric A, Coogan, Christopher, Osborn, Luke E, Schiavi, Adam, Wojtasiewicz, Teresa, Gordon, Chad R, Cohen, Adam B, Ramsey, Nick F, Schellekens, Wouter, Bensmaia, Sliman J, Cantarero, Gabriela L, Celnik, Pablo A, Wester, Brock A, Anderson, William S, Crone, Nathan E, Projectafdeling functional imaging, Brain, Highfield Research Group, McMullen, David P, Thomas, Tessy M, Fifer, Matthew S, Candrea, Daniel N, Tenore, Francesco V, Nickl, Robert W, Pohlmeyer, Eric A, Coogan, Christopher, Osborn, Luke E, Schiavi, Adam, Wojtasiewicz, Teresa, Gordon, Chad R, Cohen, Adam B, Ramsey, Nick F, Schellekens, Wouter, Bensmaia, Sliman J, Cantarero, Gabriela L, Celnik, Pablo A, Wester, Brock A, Anderson, William S, and Crone, Nathan E

Published
2021

10. Novel intraoperative online functional mapping of somatosensory finger representations for targeted stimulating electrode placement: technical note

Author

McMullen, David P., primary, Thomas, Tessy M., additional, Fifer, Matthew S., additional, Candrea, Daniel N., additional, Tenore, Francesco V., additional, Nickl, Robert W., additional, Pohlmeyer, Eric A., additional, Coogan, Christopher, additional, Osborn, Luke E., additional, Schiavi, Adam, additional, Wojtasiewicz, Teresa, additional, Gordon, Chad R., additional, Cohen, Adam B., additional, Ramsey, Nick F., additional, Schellekens, Wouter, additional, Bensmaia, Sliman J., additional, Cantarero, Gabriela L., additional, Celnik, Pablo A., additional, Wester, Brock A., additional, Anderson, William S., additional, and Crone, Nathan E., additional

Published
2021
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11. Novel intraoperative online functional mapping of somatosensory finger representations for targeted stimulating electrode placement

Author

McMullen, David P., primary, Thomas, Tessy M., additional, Fifer, Matthew S., additional, Candrea, Daniel N., additional, Tenore, Francesco V., additional, Nickl, Robert W., additional, Pohlmeyer, Eric A., additional, Coogan, Christopher, additional, Osborn, Luke E., additional, Schiavi, Adam, additional, Wojtasiewicz, Teresa, additional, Gordon, Chad, additional, Cohen, Adam B., additional, Ramsey, Nick F., additional, Schellekens, Wouter, additional, Bensmaia, Sliman J., additional, Cantarero, Gabriela L., additional, Celnik, Pablo A., additional, Wester, Brock A., additional, Anderson, William S., additional, and Crone, Nathan E., additional

Published
2020
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12. “Characteristics and stability of sensorimotor activity driven by isolated-muscle group activation in a human with tetraplegia”

Author

Nickl, Robert W., primary, Anaya, Manuel A., additional, Thomas, Tessy M., additional, Fifer, Matthew S., additional, McMullen, David P, additional, Thompson, Margaret C., additional, Candrea, Daniel N., additional, Anderson, William S., additional, Wester, Brock A., additional, Tenore, Francesco V., additional, Crone, Nathan E., additional, Celnik, Pablo A., additional, and Cantarero, Gabriela L., additional

Published
2020
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13. Simultaneous classification of bilateral hand gestures using bilateral microelectrode recordings in a tetraplegic patient

Author

Thomas, Tessy M., primary, Nickl, Robert W., additional, Thompson, Margaret C., additional, Candrea, Daniel N., additional, Fifer, Matthew S., additional, McMullen, David P., additional, Osborn, Luke E., additional, Pohlmeyer, Eric A., additional, Anaya, Manuel, additional, Anderson, William S., additional, Wester, Brock A., additional, Tenore, Francesco V., additional, Cantarero, Gabriela L., additional, Celnik, Pablo A., additional, and Crone, Nathan E., additional

Published
2020
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14. Intracortical Microstimulation Elicits Human Fingertip Sensations

Author

Fifer, Matthew S, primary, McMullen, David P, additional, Thomas, Tessy M, additional, Osborn, Luke E, additional, Nickl, Robert W, additional, Candrea, Daniel N, additional, Pohlmeyer, Eric A, additional, Thompson, Margaret C, additional, Anaya, Manuel, additional, Schellekens, Wouter, additional, Ramsey, Nick F, additional, Bensmaia, Sliman J, additional, Anderson, William S, additional, Wester, Brock A, additional, Crone, Nathan E, additional, Celnik, Pablo A, additional, Cantarero, Gabriela L, additional, and Tenore, Francesco V, additional

Published
2020
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16. A click-based electrocorticographic brain-computer interface enables long-term high-performance switch scan spelling.

Author

Candrea DN, Shah S, Luo S, Angrick M, Rabbani Q, Coogan C, Milsap GW, Nathan KC, Wester BA, Anderson WS, Rosenblatt KR, Uchil A, Clawson L, Maragakis NJ, Vansteensel MJ, Tenore FV, Ramsey NF, Fifer MS, and Crone NE

Abstract

Background: Brain-computer interfaces (BCIs) can restore communication for movement- and/or speech-impaired individuals by enabling neural control of computer typing applications. Single command click detectors provide a basic yet highly functional capability., Methods: We sought to test the performance and long-term stability of click decoding using a chronically implanted high density electrocorticographic (ECoG) BCI with coverage of the sensorimotor cortex in a human clinical trial participant (ClinicalTrials.gov, NCT03567213) with amyotrophic lateral sclerosis. We trained the participant's click detector using a small amount of training data (<44 min across 4 days) collected up to 21 days prior to BCI use, and then tested it over a period of 90 days without any retraining or updating., Results: Using a click detector to navigate a switch scanning speller interface, the study participant can maintain a median spelling rate of 10.2 characters per min. Though a transient reduction in signal power modulation can interrupt usage of a fixed model, a new click detector can achieve comparable performance despite being trained with even less data (<15 min, within 1 day)., Conclusions: These results demonstrate that a click detector can be trained with a small ECoG dataset while retaining robust performance for extended periods, providing functional text-based communication to BCI users., (© 2024. The Author(s).)

Published
2024
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17. Real-time detection of spoken speech from unlabeled ECoG signals: A pilot study with an ALS participant.

Author

Angrick M, Luo S, Rabbani Q, Joshi S, Candrea DN, Milsap GW, Gordon CR, Rosenblatt K, Clawson L, Maragakis N, Tenore FV, Fifer MS, Ramsey NF, and Crone NE

Abstract

Objective: Brain-Computer Interfaces (BCIs) hold significant promise for restoring communication in individuals with partial or complete loss of the ability to speak due to paralysis from amyotrophic lateral sclerosis (ALS), brainstem stroke, and other neurological disorders. Many of the approaches to speech decoding reported in the BCI literature have required time-aligned target representations to allow successful training - a major challenge when translating such approaches to people who have already lost their voice., Approach: In this pilot study, we made a first step toward scenarios in which no ground truth is available. We utilized a graph-based clustering approach to identify temporal segments of speech production from electrocorticographic (ECoG) signals alone. We then used the estimated speech segments to train a voice activity detection (VAD) model using only ECoG signals. We evaluated our approach using held-out open-loop recordings of a single dysarthric clinical trial participant living with ALS, and we compared the resulting performance to previous solutions trained with ground truth acoustic voice recordings., Main Results: Our approach achieves a median error rate of around 0.5 seconds with respect to the actual spoken speech. Embedded into a real-time BCI, our approach is capable of providing VAD results with a latency of only 10 ms., Significance: To the best of our knowledge, our results show for the first time that speech activity can be predicted purely from unlabeled ECoG signals, a crucial step toward individuals who cannot provide this information anymore due to their neurological condition, such as patients with locked-in syndrome., Clinical Trial Information: ClinicalTrials.gov, registration number NCT03567213., Competing Interests: Competing Interests The authors declare that they have no competing interests.

Published
2024
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18. Online speech synthesis using a chronically implanted brain-computer interface in an individual with ALS.

Author

Angrick M, Luo S, Rabbani Q, Candrea DN, Shah S, Milsap GW, Anderson WS, Gordon CR, Rosenblatt KR, Clawson L, Maragakis N, Tenore FV, Fifer MS, Hermansky H, Ramsey NF, and Crone NE

Abstract

Recent studies have shown that speech can be reconstructed and synthesized using only brain activity recorded with intracranial electrodes, but until now this has only been done using retrospective analyses of recordings from able-bodied patients temporarily implanted with electrodes for epilepsy surgery. Here, we report online synthesis of intelligible words using a chronically implanted brain-computer interface (BCI) in a clinical trial participant (ClinicalTrials.gov, NCT03567213) with dysarthria due to amyotrophic lateral sclerosis (ALS). We demonstrate a reliable BCI that synthesizes commands freely chosen and spoken by the user from a vocabulary of 6 keywords originally designed to allow intuitive selection of items on a communication board. Our results show for the first time that a speech-impaired individual with ALS can use a chronically implanted BCI to reliably produce synthesized words that are intelligible to human listeners while preserving the participants voice profile., Competing Interests: Competing Interests The authors declare that they have no competing interests.

Published
2023
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