75 results on '"Cangemi, M."'
Search Results
2. Zirconium and hafnium fractionation and distribution of Rare Earth Elements in neutral–alkaline waters: Case study of Lake Van hydrothermal system, Turkey
- Author
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Sasmaz, A., Zuddas, P., Cangemi, M., Piazzese, D., Ozek, G., Venturi, M., and Censi, P.
- Published
- 2021
- Full Text
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3. Predictive Value of CD8 Expression and FoxP3 Methylation in Nasopharyngeal Carcinoma Patients Treated with Chemoradiotherapy in a Non-endemic Area
- Author
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Muraro, E., Vaccher, E., Furlan, C., Fratta, E., Fanetti, G., Fae’, D. A., Martorelli, D., Cangemi, M., Polesel, J., Navarria, F., Gobitti, C., Comaro, E., Scaini, C., Pratesi, C., Zanussi, S., Lupato, V., Grando, G., Giacomarra, V., Sulfaro, S., Barzan, L., Dolcetti, R., Steffan, A., Canzonieri, V., and Franchin, G.
- Published
- 2020
- Full Text
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4. Shallow landslide generation at La Fossa cone, Vulcano island (Italy): a multidisciplinary perspective
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Madonia, P., Cangemi, M., Olivares, L., Oliveri, Y., Speziale, S., and Tommasi, P.
- Published
- 2019
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5. Ricerche a Solunto (2022)
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LIMONCELLI M, PORTALE C., MONTALI G, POLIZZI G, CANGEMI M, LIMONCELLI M, PORTALE C., MONTALI G, POLIZZI G, and CANGEMI M
- Subjects
Settore L-ANT/10 - Metodologie Della Ricerca Archeologica ,Solunto, Fieldwork, Sanctuary above the Theatre, Agora Baths, Virtual Reconstruction - Abstract
New Investigations at Solunto (2022) ∙ The last fieldwork campaign in Solunto by the University of Palermo, in the sanctuary above the theatre and in the baths near the agora (the North Baths), obtained some relevant results concerning both the building sequences and the architectural configurations. In the sanctuary, a clearer picture is emerging of the oldest layout, dating from the 4th century B.C. (1st phase). After the first reshaping of the street grid and of the urban layout (2nd phase), in the second half of 2nd century B.C., an overall restyling (3rd phase) gave the whole sanctuary area an impressive organization into terraces linked through ramps and stairways. A striking feature, till now unnoticed, is the stairway aligned with the front of the temple with two cellae and forecourt, which enhances the theatre on its central axis; the theatre itself has a rectilinear analemma wall on the corresponding rear (W) part. In the baths, an eastern extension of the building has been discovered and some new evidence for the function of the complex has been obtained. At the same time, the virtual reconstruction project is being carried out, integrating the results from the fieldwork into the overall framework, with the twofold objective: to test the new acquisitions, and to create a virtual tour of the ancient city, allowing a “Solunto experience”.
- Published
- 2023
6. Boron and lithium behaviour in river waters under semiarid climatic conditions
- Author
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Censi, V., primary, Zuddas, P., additional, Sposito, F., additional, Cangemi, M., additional, Inguaggiato, C., additional, and Piazzese, D., additional
- Published
- 2022
- Full Text
- View/download PDF
7. Multi-parametric study of an eruptive phase comprising unrest, major explosions, crater failure, pyroclastic density currents and lava flows: Stromboli volcano, 1 December 2020–30 June 2021
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Calvari, S., primary, Di Traglia, F., additional, Ganci, G., additional, Bruno, V., additional, Ciancitto, F., additional, Di Lieto, B., additional, Gambino, S., additional, Garcia, A., additional, Giudicepietro, F., additional, Inguaggiato, S., additional, Vita, F., additional, Cangemi, M., additional, Inguaggiato, C., additional, Macedonio, G., additional, Mattia, M., additional, Miraglia, L., additional, Nolesini, T., additional, Pompilio, M., additional, Romano, P., additional, Salerno, G., additional, Casagli, N., additional, Re, G., additional, Del Carlo, P., additional, Di Roberto, A., additional, Cappello, A., additional, Corradino, C., additional, Amato, E., additional, Torrisi, F., additional, Del Negro, C., additional, Esposito, A. M., additional, De Cesare, W., additional, Caputo, T., additional, Buongiorno, M. F., additional, Musacchio, M., additional, Romaniello, V., additional, Silvestri, M., additional, Marotta, E., additional, Avino, R., additional, Avvisati, G., additional, and Belviso, P., additional
- Published
- 2022
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8. Discrimination between Effects Induced by Microbial Activity and Water-Rock Interactions under Hydrothermal Conditions According to REE Behaviour
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Censi, P., Cangemi, M., Madonia, P., Saiano, F., Brusca, L., and Zuddas, P.
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- 2013
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9. Emerging Role of Immunomonitoring to Predict the Clinical Outcome of Patients With Malignant Pleural Mesothelioma Treated With Radical Radiation Therapy
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Cangemi, M., Montico, M., Trovo, M., Minatel, E., Di Gregorio, E., Corona, G., Giordari, F., Comaro, E., Colizzi, F., Baboci, L., Steffan, A., Revelant, A., and Muraro, E.
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Cancer Research ,Radiation ,Oncology ,Radiology, Nuclear Medicine and imaging - Abstract
The present study aimed at evaluating the baseline immune profile and the immunomodulating effects of radical hemithoracic radiation therapy (RT) in patients affected by malignant pleural mesothelioma (MPM) to identify potential predictive biomarkers of therapy response, toxicity development, and eligibility for further immunotherapeutic treatments.Blood samples were collected from 55 patients with MPM, enrolled in a phase 3 trial comparing radical hemithoracic RT (interventional arm, n = 28) with local palliative RT (control arm, n = 27). Immunomonitoring was performed before RT, at the end of treatment, and 1 month after therapy, characterizing natural killer cells, B and T lymphocytes, activated CD4 and CD8 T cells, interferon-γ- and tumor necrosis factor-α-producing T helper (Th) 1 cells, regulatory T cells, and Th17 and Th22 lymphocytes, through flow cytometry. Serum levels of interleukin (IL)-6, -8, -10 and mesothelin were quantified through Enzyme-Linked Immunosorbent Assay (ELISA) assays at the same time points. Variations in the immune parameters were investigated by Friedman test and Wilcoxon signed rank post hoc test with Bonferroni correction for multiple testing, while the prognostic effect of immune biomarkers was evaluated through Kaplan-Meier method and Spearman's correlation analysis.Major immune variations were noticed after radical RT compared with palliative treatment, in particular an improvement in activated T cells and in interferon-γ-producing Th1 cells after RT. In the interventional arm, baseline high levels of Th22 and IL-10 and an increase in T cells were associated with an improved survival, whereas a fold increase in serum mesothelin correlated with the development of severe toxicity. An improvement of immunosuppressive regulatory T cells was observed in both arms of treatment.The immunomonitoring performed in patients with MPM revealed potential prognostic biomarkers for radical hemithoracic RT treatment and identified specific immune signatures induced by RT immunomodulation, which could suggest a synergistic effect with an immunotherapeutic treatment.
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- 2022
10. Anomalous Behavior of Zirconium and Hafnium in Volcanic Fumarolic Fluids
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Censi, P., primary, Zuddas, P., additional, Caracausi, A., additional, Sortino, F., additional, Cangemi, M., additional, Piazzese, D., additional, Censi, V., additional, and Falcone, E., additional
- Published
- 2022
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11. CYTOKINE-INDUCED KILLER (CIK) CELLS EFFECTIVELY KILL CHEMO-RESISTANT MELANOMA INCLUDING PUTATIVE CANCER STEM CELLS: PH-O125
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Gammaitoni, L., Giraudo, L., Leuci, V., Mesiano, G., Todorovic, M., Cangemi, M., Zaccagna, A., Gallo, S., Pisacane, A., Carnevale-Schianca, F., Aglietta, M., and Sangiolo, D.
- Published
- 2014
12. Studio per la definizione dei modelli concettuali dei corpi idrici sotterranei di Peloritani, Nebrodi e ragu-sano e indagini geofisiche correlate
- Author
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Granata A., Castrianni G., Pasotti L. Favara R., Gagliano Candela E., Scaletta C., Madonia P., Morici S., Bellomo S., La Pica L., Gagliano A. L., Nicolosi M., Di Martino R., DI FIGLIA, Maria Grazia, Costa N., Bonfar-deci A., Perricone M., Capizzi P., Pellerito S., Cangemi M., Di Stefano P., Renda P., Martorana R., and Granata A., Castrianni G., Pasotti L. Favara R., Gagliano Candela E., Scaletta C., Madonia P., Morici S., Bellomo S., La Pica L., Gagliano A.L., Nicolosi M., Di Martino R., Di Figlia M.G., Costa N., Bonfar-deci A., Perricone M., Capizzi P., Pellerito S., Cangemi M., Di Stefano P., Renda P., Martorana R.
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Settore GEO/02 - Geologia Stratigrafica E Sedimentologica ,Settore GEO/11 - Geofisica Applicata ,Peloritani, Nebrodi, Ragusano, idrogeologia, geofisica, geochimica ,Settore GEO/08 - Geochimica E Vulcanologia - Published
- 2018
13. A meta-regression study of the clinical significance of serum aminotransferases in COVID-19.
- Author
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SOTGIA, S., MANGONI, A. A., MELLINO, S., CANGEMI, M., PALIOGIANNIS, P., FOIS, A. G., CARRU, C., and ZINELLU, A.
- Abstract
OBJECTIVE: The aim of the study was to appraise the capacity of serum aminotransferases to discriminate between hepatic and other extra-pulmonary COVID-19-related manifestations and, potentially, to serve as predictors of poor clinical outcomes. MATERIALS AND METHODS: Ninety-eight studies were identified (79% from China), including 43,554 patients (57% males), 9,983 (62% males) with poor outcomes and 33,571 (50% males) with favorable outcomes. After splitting studies depending on whether serum alanine aminotransferase (ALT) concentrations were statistically different between patients with poor vs. favorable outcomes, the 35 'hepatic involvement' articles (p<0.05) included 28,510 patients (51% males), 5,279 (66% males) and 23,231 subjects (48% males) with poor and favorable outcomes, respectively. The 63 'extra-hepatic involvement' studies (p>0.05) included 15,044 patients (54% males), 4,704 (60% males) with poor outcomes and 10,340 (51% males) with favorable outcomes. RESULTS: The meta-analysis shows that serum aspartate aminotransferase (AST) concentrations were significantly higher in patients with poor outcomes than those with favorable outcomes (WMD 12.5 UI/L, 95% CI 10.9 to 14.1 p<0.001). Similarly, AST concentrations were significantly higher in the 'hepatic involvement' studies (WMD 16.3 UI/L, 95% CI 13.4 to 19.2 p<0.001) and in the 'extra-hepatic involvement' studies (WMD 10.3 UI/L, 95% CI 8.6 to 12.0 p<0.001). CONCLUSIONS: The different association of serum AST concentrations with some clinical, demographic, and biochemical factors in the two clusters suggests that in COVID-19 patients, serum AST elevation is not necessarily linked to real liver damage. [ABSTRACT FROM AUTHOR]
- Published
- 2021
14. Platelet count does not predict bleeding in cirrhotic patients: Results from the PRO-LIVER Study
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Basili, S. a, Raparelli, V. b., Napoleone, L. b., Talerico, G. a., Corazza, G. R. c., Perticone, F. d., Sacerdoti, D. e., Andriulli, A. f., Licata, A. g., Pietrangelo, A., Picardi, A. i., Raimondo, G. j., Violi, F., Palasciano, G., D’Alitto, F., Palmieri, V. O., Santovito, D., Michele, Di, Croce, D., Brocco, G., Fasolato, S., Cecchetto, S., Bombonato, L., Bertoni, G., Restuccia, M., Andreozzi, T., Liguori, P., Caroleo, M. L., Perticone, B., Staltari, M., Manfredini, O., Giorgi, De, Averna, A., Giammanco, M., Granito, A., Pettinari, A., Marinelli, I., Bolondi, S., Falsetti, L., Salvi, L., Durante-Mangoni, A., Cesaro, E., Farinaro, F., Ragone, V., Morana, E., Ippolito, I., Iacobellis, A., Niro, A., Merla, G., Maimone, A., Cacciola, S., Varvara, I., Drenaggi, D., Staffolani, D., Vespasiani-Gentilucci, S., Galati, U., Gallo, G., Davì, P., Schiavone, G., Santilli, C., Tana, F., Soresi, C., Bianchi, Giovanni, Carderi, B., Pinto, I., Tuttolomondo, A., Ferrari, A., Gresele, G., Fierro, P., Morelli, T., Laffi, O., Romanelli, G., Arena, R. G., Stasi, U., Gasbarrini, A., Garcovich, M., Zocco, M. A., Riccardi, L., Ainora, M. E., Capeci, W., Martino, Giuseppe, Nobili, P., Cavallo, L., Frugiuele, M., Greco, P., Ventura, P., Cuoghi, C., Marcacci, M., Serviddio, G., Vendemiale, G., Villani, R., Gargano, R., Vidili, G., Cesare, Di, Masala, V., Delitala, M., Invernizzi, G., Vincenzo, P., Minno, Di, Tufano, G., Purrello, A., Privitera, F., Forgione, G., Curigliano, A., Senzolo, V., Rodríguez-Castro, M., Giannelli, K. I., Serra, G., Neri, C., Pignataro, S., Rizzetto, P., Debernardi, M., Svegliati, V. W., Bergamaschi, B. G., Masotti, G., Costanzo, M., Antonio, F., Angelico, F., Del, Ben, Polimeni, M., Proietti, L., Cangemi, M., Romiti, R., Toriello, G. F., Sperduti, F., Santangelo, N., Visioli, G., Todisco, G., Vestri, Anna, Farcomeni, R., Corrao, A., Gobbi, S., Corradini, E., Costantino, G., Tripepi, G., Angelico, M., Bolondi, L., D’Amico, G., Franchis, De, Gatta, R., Tassone, A., Anzaldi, E. J., Barone, M., Bazzini, M., Bianchi, C., Boari, P. I., Bracco, B., Buonauro, C., Buttà, A., Buzzetti, E., Calabria, S., Caradio, F., Carleo, P., Carrabba, Maria, Castorani, D., Cecchetto, L., Cicco, L., Cimini, S., Colombo, C., B. M., Vuono, De, Denegri, S., Del, Corso, Giosia, Di, Donnarumma, P., Giorgini, E., Grassi, P., Grembiale, D., Hijazi, A., Iamele, D., Lorusso, L., Marchese, G., Marra, Alberto, Masala, M., Miceli, M., Montebianco, G., Murgia, A. L., Naccarato, G., Padula, P., Pattoneri, D., Perego, P., Pesce, F., Petramala, P., Piano, L., Pinto, S., Pinna, D., Pignataro, M., Pretti, F. S., Pucci, V., Salinaro, G., Salzano, F., Santarossa, A., Scarpini, C., Scicali, F., Sirico, R., Suppressa, D., Talia, P., Torres, M., Traversa, D., Vazzana, M., Vecchio, Claudia, Vettore, R., Vitale, E., Basili, S., Raparelli, V., Napoleone, L., Talerico, G., Corazza, G.R., Perticone, F., Sacerdoti, D., Andriulli, A., Licata, A., Pietrangelo, A., Picardi, A., Raimondo, G., Violi, F., Palasciano, Giuseppe, D’Alitto, Felicia, Palmieri, Vincenzo Ostilio, Santovito, Daniela, Di Michele, Dario, Croce, Giuseppe, Brocco, Silvia, Fasolato, Silvano, Cecchetto, Lara, Bombonato, Giancarlo, Bertoni, Michele, Restuccia, Tea, Andreozzi, Paola, Liguori, Maria Livia, Caroleo, Benedetto, Perticone, Maria, Staltari, Orietta, Manfredini, Roberto, De Giorgi, Alfredo, Averna, Maurizio, Giammanco, Antonina, Granito, Alessandro, Pettinari, Irene, Marinelli, Sara, Bolondi, Luigi, Falsetti, Lorenzo, Salvi, Aldo, Durante-Mangoni, Emanuele, Cesaro, Flavio, Farinaro, Vincenza, Ragone, Enrico, Morana, Ignazio, Ippolito, Antonio, Iacobellis, Angelo, Niro, Grazia, Merla, Antonio, Maimone, Sergio, Cacciola, Irene, Varvara, Doriana, Drenaggi, Davide, Staffolani, Silvia, Vespasiani-Gentilucci, Umberto, Galati, Giovanni, Gallo, Paolo, Davì, Giovanni, Schiavone, Cosima, Santilli, Francesca, Tana, Claudio, Soresi, Maurizio, Bianchi Giovanni, Battista, Carderi, Isabella, Pinto, Antonio, Tuttolomondo, Antonino, Ferrari, Giovanni, Gresele, Paolo, Fierro, Tiziana, Morelli, Olivia, Laffi, Giacomo, Romanelli, Roberto Giulio, Arena, Umberto, Stasi, Cristina, Gasbarrini, Antonio, Garcovich, Matteo, Zocco, Maria Assunta, Riccardi, Laura, Ainora, Maria Elena, Capeci, William, Martino Giuseppe, Pio, Nobili, Lorenzo, Cavallo, Maurizio, Frugiuele, Pierluigi, Greco, Antonio, Ventura, Paolo, Cuoghi, Chiara, Marcacci, Matteo, Serviddio, Gaetano, Vendemiale, Gianluigi, Villani, Rosanna, Gargano, Ruggiero, Vidili, Gianpaolo, Di Cesare, Valentina, Masala, Maristella, Delitala, Giuseppe, Invernizzi, Pietro, Vincenzo, Ronca, Di Minno, Giovanni, Tufano, Antonella, Purrello, Francesco, Privitera, Graziella, Forgione, Alessandra, Curigliano, Valentina, Senzolo, Marco, Rodríguez-Castro, Kryssia Isabel, Giannelli, Gianluigi, Serra, Carla, Neri, Sergio, Pignataro, Pietro, Rizzetto, Mario, Debernardi, Venon Wilma, Svegliati, Baroni Gianluca, Bergamaschi, Gaetano, Masotti, Michela, Costanzo, Filippo, Antonio, Figliomeni, Angelico, Francesco, Del Ben, Maria, Polimeni, Licia, Proietti, Marco, Cangemi, Roberto, Romiti Giulio, Francesco, Toriello, Filippo, Sperduti, Nicolò, Santangelo, Giuseppe, Visioli, Giacomo, Todisco, Tommaso, Vestri Anna, Rita, Farcomeni, Alessio, Corrao, Salvatore, Gobbi, Paolo, Corradini, Elena, Costantino, Giorgio, Tripepi, Giovanni, Angelico, Mario, D’Amico, Gennaro, De Franchis, Roberto, Gatta, Angelo, Tassone, Eliezer Joseph, Anzaldi, Massimiliano, Barone, Milena, Bazzini, Cristina, Bianchi, Paola Ilaria, Boari, Benedetta, Bracco, Christian, Buonauro, Agostino, Buttà, Carmelo, Buzzetti, Elena, Calabria, Stefano, Caradio, Federica, Carleo, Pietro, Carrabba Maria, Domenica, Castorani, Luigi, Cicco, Sebastiano, Cimini, Claudia, Colombo, Barbara Maria, De Vuono, Stefano, Denegri, Andrea, Del Corso, Lisette, Di Giosia, Paolo, Donnarumma, Emilia, Giorgini, Paolo, Grassi, Davide, Grembiale, Alessandro, Hijazi, Daniel, Iamele, Luigi, Lorusso, Giusi, Marchese, Alessandra, Marra Alberto, Maria, Miceli, Giuseppe, Montebianco, Abenavoli Ludovico, Murgia, Giuseppe, Naccarato, Paola, Padula, Donatella, Pattoneri, Paolo, Perego, Francesca, Pesce, Paola, Petramala, Luigi, Piano, Salvatore, Pinto, Daniela, Pinna, Miriam, Pignataro, Francesca Serena, Pretti, Vincenzo, Pucci, Giacomo, Salinaro, Francesco, Salzano, Andrea, Santarossa, Claudia, Scarpini, Francesca, Scicali, Roberto, Sirico, Domenico, Suppressa, Patrizia, Talia, Michela, Torres, Daniele, Traversa, Matteo, Vazzana, Natale, Vecchio Claudia, Rita, Vettore, Elia, Vitale, Francesco, Basili, S, Raparelli, V, Napoleone, L, Talerico, G, Corazza, G, Perticone, F, Sacerdoti, D, Andriulli, A, Licata, A, Pietrangelo, A, Picardi, A, Raimondo, G, Violi, F, Palasciano, G, D'Alitto, F, Palmieri, V, Santovito, D, Di Michele, D, Croce, G, Brocco, S, Fasolato, S, Cecchetto, L, Bombonato, G, Bertoni, M, Restuccia, T, Andreozzi, P, Liguori, M, Caroleo, B, Perticone, M, Staltari, O, Manfredini, R, De Giorgi, A, Averna, M, Giammanco, A, Granito, A, Pettinari, I, Marinelli, S, Bolondi, L, Falsetti, L, Salvi, A, Durante-Mangoni, E, Cesaro, F, Farinaro, V, Ragone, E, Morana, I, Ippolito, A, Iacobellis, A, Niro, G, Merla, A, Maimone, S, Cacciola, I, Varvara, D, Drenaggi, D, Staffolani, S, Vespasiani-Gentilucci, U, Galati, G, Gallo, P, Davi, G, Schiavone, C, Santilli, F, Tana, C, Soresi, M, Bianchi Giovanni, B, Carderi, I, Pinto, A, Tuttolomondo, A, Ferrari, G, Gresele, P, Fierro, T, Morelli, O, Laffi, G, Romanelli, R, Arena, U, Stasi, C, Gasbarrini, A, Garcovich, M, Zocco, M, Riccardi, L, Ainora, M, Capeci, W, Martino Giuseppe, P, Nobili, L, Cavallo, M, Frugiuele, P, Greco, A, Ventura, P, Cuoghi, C, Marcacci, M, Serviddio, G, Vendemiale, G, Villani, R, Gargano, R, Vidili, G, Di Cesare, V, Masala, M, Delitala, G, Invernizzi, P, Vincenzo, R, Di Minno, G, Tufano, A, Purrello, F, Privitera, G, Forgione, A, Curigliano, V, Senzolo, M, Rodriguez-Castro, K, Giannelli, G, Serra, C, Neri, S, Pignataro, P, Rizzetto, M, Debernardi, V, Svegliati, B, Bergamaschi, G, Masotti, M, Costanzo, F, Antonio, F, Angelico, F, Del Ben, M, Polimeni, L, Proietti, M, Cangemi, R, Romiti, G, Toriello, F, Sperduti, N, Santangelo, G, Visioli, G, Todisco, T, Vestri Anna, R, Farcomeni, A, Corrao, S, Gobbi, P, Corradini, E, Costantino, G, Tripepi, G, Angelico, M, D'Amico, G, De Franchis, R, Gatta, A, Tassone, E, Anzaldi, M, Barone, M, Bazzini, C, Bianchi, P, Boari, B, Bracco, C, Buonauro, A, Butta, C, Buzzetti, E, Calabria, S, Caradio, F, Carleo, P, Carrabba Maria, D, Castorani, L, Cicco, S, Cimini, C, Colombo, B, De Vuono, S, Denegri, A, Del Corso, L, Di Giosia, P, Donnarumma, E, Giorgini, P, Grassi, D, Grembiale, A, Hijazi, D, Iamele, L, Lorusso, G, Marchese, A, Marra, A, Miceli, G, Montebianco, A, Murgia, G, Naccarato, P, Padula, D, Pattoneri, P, Perego, F, Pesce, P, Petramala, L, Piano, S, Pinto, D, Pinna, M, Pignataro, F, Pretti, V, Pucci, G, Salinaro, F, Salzano, A, Santarossa, C, Scarpini, F, Scicali, R, Sirico, D, Suppressa, P, Talia, M, Torres, D, Traversa, M, Vazzana, N, Vecchio Claudia, R, Vettore, E, Vitale, F, S Basili, V Raparelli, L Napoleone, G Talerico, G Corazza, F Perticone, D Sacerdoti, A Andriulli, A Licata, A Pietrangelo, A Picardi, G Raimondo, F Violi, MD on behalf of PRO-LIVER Collaborator, Palasciano Giuseppe, D’Alitto Felicia, Palmieri Vincenzo Ostilio, Santovito Daniela, Di Michele Dario, Croce Giuseppe, Brocco Silvia, Fasolato Silvano, Cecchetto Lara, Bombonato Giancarlo, Bertoni Michele, Restuccia Tea, Andreozzi Paola, Liguori Maria Livia, Caroleo Benedetto, Perticone Maria, Staltari Orietta, Manfredini Roberto, De Giorgi Alfredo, Averna Maurizio, Giammanco Antonina, Granito Alessandro, Pettinari Irene, Marinelli Sara, Bolondi Luigi, Falsetti Lorenzo, Salvi Aldo, Durante-Mangoni Emanuele, Cesaro Flavio, Farinaro Vincenza, Ragone Enrico, Morana Ignazio, Ippolito Antonio, Iacobellis Angelo, Niro Grazia, Merla Antonio, Maimone Sergio, Cacciola Irene, Varvara Doriana, Drenaggi Davide, Staffolani Silvia, Vespasiani-Gentilucci Umberto, Galati Giovanni, Gallo Paolo, Davi Giovanni, Schiavone Cosima, Santilli Francesca, Tana Claudio, Soresi Maurizio, Bianchi Giovanni Battista, Carderi Isabella, Pinto Antonio, Tuttolomondo Antonino, Ferrari Giovanni, Gresele Paolo, Fierro Tiziana, Morelli Olivia, Laffi Giacomo, Romanelli Roberto Giulio, Arena Umberto, Stasi Cristina, Gasbarrini Antonio, Garcovich Matteo, Zocco Maria Assunta, Riccardi Laura, Ainora Maria Elena, Capeci William, Martino Giuseppe Pio, Nobili Lorenzo, Cavallo Maurizio, Frugiuele Pierluigi, Greco Antonio, Ventura Paolo, Cuoghi Chiara, Marcacci Matteo, Serviddio Gaetano, Vendemiale Gianluigi, Villani Rosanna, Gargano Ruggiero, Vidili Gianpaolo, Di Cesare Valentina, Masala Maristella, Delitala Giuseppe, Invernizzi Pietro, Vincenzo Ronca, Di Minno Giovanni, Tufano Antonella, Purrello Francesco, Privitera Graziella, Forgione Alessandra, Curigliano Valentina, Senzolo Marco, Rodríguez-Castro Kryssia Isabel, Giannelli Gianluigi, Serra Carla, Neri Sergio, Pignataro Pietro, Rizzetto Mario, Debernardi Venon Wilma, Svegliati Baroni Gianluca, Bergamaschi Gaetano, Masotti Michela, Costanzo Filippo, Antonio Figliomeni, Angelico Francesco, Del Ben Maria, Polimeni Licia, Proietti Marco, Cangemi Roberto, Romiti Giulio Francesco, Toriello Filippo, Sperduti Nicolò, Santangelo Giuseppe, Visioli Giacomo, Todisco Tommaso, Vestri Anna Rita, Farcomeni Alessio, Corrao Salvatore, Gobbi Paolo, Corradini Elena, Costantino Giorgio, Tripepi Giovanni, Angelico Mario, D’Amico Gennaro, de Franchis Roberto, Gatta Angelo, Tassone Eliezer Joseph, Anzaldi Massimiliano, Barone Milena, Bazzini Cristina, Bianchi Paola Ilaria, Boari Benedetta, Bracco Christian, Buonauro Agostino, Buttà Carmelo, Buzzetti Elena, Calabria Stefano, Caradio Federica, Carleo Pietro, Carrabba Maria Domenica, Castorani Luigi, Cicco Sebastiano, Cimini Claudia, Colombo Barbara Maria, De Vuono Stefano, Denegri Andrea, Del Corso Lisette, Di Giosia Paolo, Donnarumma Emilia, Giorgini Paolo, Grassi Davide, Grembiale Alessandro, Hijazi Daniel, Iamele Luigi, Lorusso Giusi, Marchese Alessandra, Marra Alberto Maria, Miceli Giuseppe, Montebianco Abenavoli Ludovico, Murgia Giuseppe, Naccarato Paola, Padula Donatella, Pattoneri Paolo, Perego Francesca, Pesce Paola, Petramala Luigi, Piano Salvatore, Pinto Daniela, Pinna Miriam, Pignataro Francesca Serena, Pretti Vincenzo, Pucci Giacomo, Salinaro Francesco, Salzano Andrea, Santarossa Claudia, Scarpini Francesca, Scicali Roberto, Sirico Domenico, Suppressa Patrizia, Talia Michela, Torres Daniele, Traversa Matteo, Vazzana Natale, Vecchio Claudia Rita, Vettore Elia, Vitale Francesco, Corazza, G. R., Guidacci, Raimondo, Palasciano, G., D'Alitto, F., Palmieri, V. O., Santovito, D., Di Michele, D., Croce, G., Brocco, S., Fasolato, S., Cecchetto, L., Bombonato, G., Bertoni, M., Restuccia, T., Andreozzi, P., Liguori, M. L., Caroleo, B., Perticone, M., Staltari, O., Manfredini, R., De Giorgi, A., Averna, M., Giammanco, A., Granito, A., Pettinari, I., Marinelli, S., Bolondi, L., Falsetti, L., Salvi, A., Durante-Mangoni, E., Cesaro, F., Farinaro, V., Ragone, E., Morana, I., Ippolito, A., Iacobellis, A., Niro, G., Merla, A., Maimone, S., Cacciola, I., Varvara, D., Drenaggi, D., Staffolani, S., Vespasiani-Gentilucci, U., Galati, G., Gallo, P., Davi, G., Schiavone, C., Santilli, F., Tana, C., Soresi, M., Bianchi Giovanni, B., Carderi, I., Pinto, A., Tuttolomondo, A., Ferrari, G., Gresele, P., Fierro, T., Morelli, O., Laffi, G., Romanelli, R. G., Arena, U., Stasi, C., Gasbarrini, A., Garcovich, M., Zocco, M. A., Riccardi, L., Ainora, M. E., Capeci, W., Martino Giuseppe, P., Nobili, L., Cavallo, M., Frugiuele, P., Greco, A., Ventura, P., Cuoghi, C., Marcacci, M., Serviddio, G., Vendemiale, G., Villani, R., Gargano, R., Vidili, G., Di Cesare, V., Masala, M., Delitala, G., Invernizzi, P., Vincenzo, R., Di Minno, G., Tufano, A., Purrello, F., Privitera, G., Forgione, A., Curigliano, V., Senzolo, M., Rodriguez-Castro, K. I., Giannelli, G., Serra, C., Neri, S., Pignataro, P., Rizzetto, M., Debernardi, V. W., Svegliati, B. G., Bergamaschi, G., Masotti, M., Costanzo, F., Antonio, F., Angelico, F., Del Ben, M., Polimeni, L., Proietti, M., Cangemi, R., Romiti, G. F., Toriello, F., Sperduti, N., Santangelo, G., Visioli, G., Todisco, T., Vestri Anna, R., Farcomeni, A., Corrao, S., Gobbi, P., Corradini, E., Costantino, G., Tripepi, G., Angelico, M., D'Amico, G., De Franchis, R., Gatta, A., Tassone, E. J., Anzaldi, M., Barone, M., Bazzini, C., Bianchi, P. I., Boari, B., Bracco, C., Buonauro, A., Butta, C., Buzzetti, E., Calabria, S., Caradio, F., Carleo, P., Carrabba Maria, D., Castorani, L., Cicco, S., Cimini, C., Colombo, B. M., De Vuono, S., Denegri, A., Del Corso, L., Di Giosia, P., Donnarumma, E., Giorgini, P., Grassi, D., Grembiale, A., Hijazi, D., Iamele, L., Lorusso, G., Marchese, A., Marra, A. M., Miceli, G., Montebianco, A. L., Murgia, G., Naccarato, P., Padula, D., Pattoneri, P., Perego, F., Pesce, P., Petramala, L., Piano, S., Pinto, D., Pinna, M., Pignataro, F. S., Pretti, V., Pucci, G., Salinaro, F., Salzano, A., Santarossa, C., Scarpini, F., Scicali, R., Sirico, D., Suppressa, P., Talia, M., Torres, D., Traversa, M., Vazzana, N., Vecchio Claudia, R., Vettore, E., and Vitale, F.
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Liver Cirrhosis ,Male ,Settore MED/09 - Medicina Interna ,030204 cardiovascular system & hematology ,Gastroenterology ,Severity of Illness Index ,cjirrhosis ,ACTIVATION ,0302 clinical medicine ,Risk Factors ,Medicine ,Platelet ,Prospective Studies ,Prospective cohort study ,RISK ,Aged, 80 and over ,medicine.diagnostic_test ,PRO-LIVER ,Platelet, cirrhosis, gastrointestinal bleeding ,ASSOCIATION ,Middle Aged ,Prognosis ,Italy ,030211 gastroenterology & hepatology ,Female ,Gastrointestinal Hemorrhage ,Human ,Adult ,Platelets ,medicine.medical_specialty ,Prognosi ,Liver Cirrhosi ,MEDLINE ,COAGULATION ,gastrointestinal bleeding ,Socio-culturale ,Hemorrhage ,Hepatology ,Follow-Up Studie ,03 medical and health sciences ,Text mining ,Internal medicine ,Severity of illness ,ENDOTOXEMIA ,Pro-Liver Study ,Humans ,HEMOSTASIS ,International Normalized Ratio ,Aged ,Proportional Hazards Models ,Prothrombin time ,Cirrhosi ,Platelet Count, Bleeding, Liver Cirrhosis ,business.industry ,Proportional hazards model ,Platelet Count ,Risk Factor ,cirrhosis ,bleeding ,Thrombocytopenia ,Prospective Studie ,THROMBOSIS ,Platelets, cjirrhosis, bleeding, PRO-LIVER ,Proportional Hazards Model ,Prothrombin Time ,business ,DECOMPENSATED CIRRHOSIS ,Follow-Up Studies - Abstract
OBJECTIVES: Thrombocytopenia is a hallmark for patients with cirrhosis and it is perceived as a risk factor for bleeding events. However, the relationship between platelet count and bleeding is still unclear. METHODS: We investigated the relationship between platelet count and major or clinical relevant nonmajor bleedings during a follow-up of â¼4 years. RESULTS: A total of 280 cirrhotic patients with different degrees of liver disease (67% males; age 64±37 years; 47% ChildâPugh B and C) were followed up for a median of 1,129 (interquartile range: 800â1,498) days yielding 953.12 patient-year of observation. The annual rate of any significant bleeding was 5.45%/year (3.57%/year and 1.89%/year for major and minor bleeding, respectively). Fifty-two (18.6%) patients experienced a major (n=34) or minor (n=18) bleeding event, predominantly from gastrointestinal origin. Platelet counts progressively decreased with the worsening of liver disease and were similar in patients with or without major or minor bleeding: a platelet count â¤50Ã103/μl was detected in 3 (6%) patients with and in 20 (9%) patients without any bleeding event. Conversely, prothrombin time-international normalized ratio was slightly higher in patients with overall or major bleeding. On Cox proportional hazard analysis, only a previous gastrointestinal bleeding (hazard ratio (HR): 1.96; 95% confidence interval: 1.11â3.47; P=0.020) and encephalopathy (HR: 2.05; 95% confidence interval: 1.16â3.62; P=0.013) independently predicted overall bleeding events. CONCLUSIONS: Platelet count does not predict unprovoked major or minor bleeding in cirrhotic patients.
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- 2018
15. INTRANODAL TREATMENT WITH IFNΑ-DENDRITIC CELLS AND RITUXIMAB INDUCES SYSTEMIC CLINICAL RESPONSE AND ENDOGENOUS VACCINATION AGAINST FOLLICULAR LYMPHOMA: FINAL RESULT OF A PHASE I STUDY
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Cox, C., primary, Castiello, L., additional, Mattei, M., additional, Santodonato, L., additional, D'agostino, G., additional, Muraro, E., additional, Martorelli, D., additional, Lapenta, C., additional, Di Napoli, A., additional, Di Landro, F., additional, Cangemi, M., additional, Pavan, A., additional, Castaldo, P., additional, Hohaus, S., additional, Donati, S., additional, Montefiore, E., additional, Berdini, C., additional, Borgioni, S., additional, Carlei, D., additional, Monque, D., additional, Ruco, L., additional, Prosperi, D., additional, Tafuri, A., additional, Spadaro, F., additional, Sestili, P., additional, Spada, M., additional, Dolcetti, R., additional, Santini, S., additional, Rozera, C., additional, Arico', E., additional, Capone, I., additional, and Belardelli, F., additional
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- 2019
- Full Text
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16. Potentially harmful elements released by volcanic ashes: Examples from the Mediterranean area
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Cangemi, M. Speziale, S. Madonia, P. D'Alessandro, W. Andronico, D. Bellomo, S. Brusca, L. Kyriakopoulos, K.
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technology, industry, and agriculture ,complex mixtures - Abstract
We have performed leaching experiments on the fine (< 2 mm) particulate sampled in seven active and quiescent volcanic systems in the Mediterranean area. We reacted the particulate both in pure water and in a synthetic gastric solution. The amount of As, Mn, Pb, Ba, U and Ni leached by pure water exceeded the MAC limits for drinking water in all the materials under investigation. We defined a tolerable ash intake index (TAI) to evaluate the impact of ash ingestion, and we find that 0.2 g and 12 g of ingested fine ash from Vesuvius and Vulcano are enough to exceed the safety limits for Pb and As. Six grams of fine ashes from Stromboli are sufficient to overstep the safety limits for As. Based on our mineralogical characterisation of the particulate, we expect that the submillimetric ash fraction, with a higher surface/volume ratio, releases a greater relative amount of trace metals, which are concentrated in the thin surface layer produced by the reaction of the pristine volcanic particles with coexisting volcanic gases. This means that our measurements represent lower bounds to the actual amount of metal released in aqueous solutions by the volcanic ashes from the locations under investigation. Our results place the first constraints on the mobilisation of toxic elements from volcanic ash, which are necessary to assess the associated potential health risk of volcanic areas. © 2017 Elsevier B.V.
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- 2017
17. Diseño de viviendas de interés social : Su adecuación a las condiciones climáticas de Tucumán
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Cangemi, M. C., Ledesma, Sara Lía, and Nota, V. M.
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Energía ,Vivienda social ,Ingeniería ,Habitabilidad ,Clima ,Arquitectura - Abstract
El trabajo presenta la propuesta de diseño de viviendas de interés social desarrollada por el Instituto Provincial de la Vivienda y Desarrollo Urbano de Tucumán, en el marco del Proyecto GEF “Eficiencia energética y energías renovables en la vivienda social”. Se tuvo como premisa de diseño disminuir la demanda energética en las viviendas construidas por el Estado y se proyectaron respondiendo a pautas bioclimáticas adecuadas al sitio de emplazamiento. Se evaluó el comportamiento energético-ambiental de las propuestas comparativamente con las viviendas sociales convencionales. A partir de cálculos computacionales, ecuaciones simplificadas y métodos gráficos se analizó el comportamiento térmico, condiciones de asoleamiento y ventilación natural de las viviendas. Los resultados alcanzados demuestran que es posible mejorar sustancialmente el comportamiento energético de las viviendas a partir de un diseño eficiente, sin incrementar significativamente sus costos., The work presents the design proposal of social housing developed by the Provincial Institute of Housing and Urban Development (IPVyDU) of Tucuman, in the context of the GEF (Global Environment Facility) "Energy efficiency and renewable energies in social housing". The design is focused on reducing energy demand in homes built by the State and projected under patterns of adaptation in response to the climatic conditions of the proposed site. We evaluated the energyenvironmental behavior of the proposals in comparison with conventional proyects designed by IPVyDU. From computer calculations, simplified equations and graphical methods, we analyzed the thermal behavior, conditions of sunlight and natural ventilation of houses. The results obtained show that it is possible to substantially improve the energy performance of social housing from an efficient design without significantly increasing costs., Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES)
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- 2013
18. The behavior of rare-earth elements, Zr and Hf during biologically-mediated deposition of silica-stromatolites and carbonate-rich microbial mats
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Censi, P., primary, Cangemi, M., additional, Brusca, L., additional, Madonia, P., additional, Saiano, F., additional, and Zuddas, P., additional
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- 2015
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19. A SEM Record of Proteins-Derived Microcellular Silicon Carbide Foams
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Pizzi, A., primary, Zollfrank, C., additional, Li, X., additional, Cangemi, M., additional, and Celzard, A., additional
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- 2014
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20. Sur la theorie des anneaux excellents en caractéristique p, III: Algébres Kahlhériennes
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Seydi, H, Restuccia, Gaetana, Bonanzinga, V, Cangemi, M. R., and Utano, Rosanna
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- 1996
21. Algebre con modulo universale finito dei differenziali
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Bonanzinga, V, Cangemi, M. R., and Utano, Rosanna
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- 1996
22. Insulation rigid and elastic foams based on albumin
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Li, X., primary, Pizzi, A., additional, Cangemi, M., additional, Navarrete, P., additional, Segovia, C., additional, Fierro, V., additional, and Celzard, A., additional
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- 2012
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23. Flexible natural tannin-based and protein-based biosourced foams
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Li, X., primary, Pizzi, A., additional, Cangemi, M., additional, Fierro, V., additional, and Celzard, A., additional
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- 2012
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24. Geomorphological and geochemical characterization of the 11 August 2008 mud volcano eruption at S. Barbara village (Sicily, Italy) and its possible relationship with seismic activity
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Madonia, P., primary, Grassa, F., additional, Cangemi, M., additional, and Musumeci, C., additional
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- 2011
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25. SOME PROBLEMS ON P-MORPHISMS IN CODIMENSION AND CODEPTH k
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Imbesi, Maurizio and Cangemi, M. R.
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- 1993
26. EUVL dosimetry at NIST
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Tarrio, C., primary, Grantham, S., additional, Cangemi, M., additional, Vest, R. E., additional, Lucatorto, T. B., additional, and Harned, Noreen, additional
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- 2009
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27. EUVL dosimetry at NIST.
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Tarrio, C., Grantham, S., Cangemi, M., Vest, R. E., Lucatorto, T. B., and Harned, Noreen
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- 2009
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28. Rare earths release from dissolving atmospheric dust and their accumulation into crystallising halite. The dead-sea example
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P. Censi, I. Sirota, P. Zuddas, N.G. Lensky, O. Crouvi, M. Cangemi, D. Piazzese, Censi, P, Sirota, null, Zuddas, P, Lensky, N G, Crouvi, O, Cangemi, M, and Piazzese, D
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Environmental Engineering ,Dead Sea brines, Halite, Lanthanum anomaly, Rare earth elements ,Environmental Chemistry ,Pollution ,Waste Management and Disposal - Abstract
The industrial extraction of Y and lanthanides (hereafter defined as Rare Earth Elements, REE) often requires the achievement of leaching procedures removing these metals from primary rocks and their transfer in aqueous leachates or incorporated in newly forming soluble solids. These procedures are the most dangerous to the environment in relation to the composition of leachates. Hence, the recognition of natural settings where these processes currently occur, represents a worthy challenge for learning how to carry out similar industrial procedures under natural and more eco-friendly conditions. Accordingly, the REE distribution was studied in the brine of Dead Sea, a terminal evaporating basin where brines dissolve atmospheric fallout particles and crystallise halite. Our results indicate that the shale-like fractionation of shale-normalised REE patterns in brines, inherited during the dissolution of atmospheric fallout, changes because of the halite crystallisation. This process leads to crystallising halite mainly enriched in elements from Sm to Ho (medium REE, MREE) and coexisting mother brines enriched in La and some other light REE (LREE). We suggest that the dissolution of atmospheric dust in brines corresponds to the REE extraction from primary silicate rocks, whereas halite crystallisation represents the REE transfer into a secondary more soluble deposit with reduced environmental health outcomes.
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- 2023
29. Predictive Value of CD8 Expression and FoxP3 Methylation in Nasopharyngeal Carcinoma Patients Treated with Chemoradiotherapy in a Non-endemic Area
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Damiana Antonia Faè, Riccardo Dolcetti, Debora Martorelli, Luigi Barzan, Carlo Gobitti, E. Comaro, F. Navarria, C. Furlan, Giuseppe Fanetti, Sandro Sulfaro, Elena Muraro, Agostino Steffan, Giovanni Franchin, Chiara Pratesi, Stefania Zanussi, Emanuela Vaccher, Valentina Lupato, Jerry Polesel, Michela Cangemi, Vittorio Giacomarra, Vincenzo Canzonieri, C. Scaini, Giuseppe Grando, Elisabetta Fratta, Muraro, E., Vaccher, E., Furlan, C., Fratta, E., Fanetti, G., Fae', D. A., Martorelli, D., Cangemi, M., Polesel, J., Navarria, F., Gobitti, C., Comaro, E., Scaini, C., Pratesi, C., Zanussi, S., Lupato, V., Grando, G., Giacomarra, V., Sulfaro, S., Barzan, L., Dolcetti, R., Steffan, A., Canzonieri, V., and Franchin, G.
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Male ,0301 basic medicine ,Oncology ,Epstein-Barr Virus Infections ,Cancer Research ,medicine.medical_treatment ,Radiation Tolerance ,0302 clinical medicine ,Tumor Microenvironment ,CD8 ,Chemoradiotherapy ,EBV-specific immunity ,FoxP3 ,Immunosuppression ,Nasopharyngeal carcinoma ,ELISPOT ,FOXP3 ,Forkhead Transcription Factors ,General Medicine ,Middle Aged ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,Adult ,medicine.medical_specialty ,Adolescent ,CD8 Antigens ,T cell ,Pathology and Forensic Medicine ,Viral Proteins ,Young Adult ,03 medical and health sciences ,Immune system ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Aged ,Retrospective Studies ,business.industry ,Nasopharyngeal Neoplasms ,DNA Methylation ,medicine.disease ,030104 developmental biology ,Drug Resistance, Neoplasm ,business - Abstract
Undifferentiated Nasopharyngeal Carcinoma (UNPC) is associated with Epstein-Barr Virus (EBV) and characterized by an abundant immune infiltrate potentially influencing the prognosis. Thus, we retrospectively assessed the significance of immunosuppression in the UNPC microenvironment as prognostic biomarker of treatment failure in a non-endemic area, and monitored the variation of systemic EBV-specific immunity before and after chemoradiotherapy (CRT). DNA and RNA were extracted from diagnostic biopsies obtained by tumor and adjacent mucosa from 63 consecutive EBV+ UNPC patients who underwent radical CRT. Among these patients 11 relapsed within 2 years. The expression of the EBV-derived UNPC-specific BARF1 gene and several immune-related genes was monitored through quantitative RT-PCR and methylation-specific PCR analyses. Peripheral T cell responses against EBV and BARF1 were measured in 14 patients (7 relapses) through IFN-γ ELISPOT assay. We found significantly higher expression levels of BARF1, CD8, IFN-γ, IDO, PD-L1, and PD-1 in UNPC samples compared to healthy tissues. CD8 expression was significantly reduced in both tumor and healthy tissues in UNPC patients who relapsed within two years. We observed a hypomethylated FOXP3 intron 1 exclusively in relapsed UNPC patients. Finally, we noticed a significant decrease in EBV- and BARF1-specific T-cells after CRT only in relapsing patients. Our data suggest that a high level of immunosuppression (low CD8, hypomethylated FoxP3) in UNPC microenvironment may predict treatment failure and may allow an early identification of patients who could benefit from the addition of immune modulating strategies to improve first line CRT.
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- 2020
30. Zirconium and hafnium fractionation and distribution of Rare Earth Elements in neutral–alkaline waters: Case study of Lake Van hydrothermal system, Turkey
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M. Venturi, G. Ozek, Paolo Censi, Ahmet Sasmaz, Pierpaolo Zuddas, Marianna Cangemi, Daniela Piazzese, Firat University, Institut des Sciences de la Terre de Paris (iSTeP), Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut national des sciences de l'Univers (INSU - CNRS), Università degli studi di Palermo - University of Palermo, Sasmaz A., Zuddas P., Cangemi M., Piazzese D., Ozek G., Venturi M., and Censi P.
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Calcite ,Zirconium ,Aqueous solution ,Turkey ,Chemistry ,Inorganic chemistry ,Carbonate minerals ,chemistry.chemical_element ,Alkaline lakes, REE, Turkey, Zr/Hf ratio ,Authigenic ,Fractionation ,010501 environmental sciences ,010502 geochemistry & geophysics ,REE ,Alkaline lakes ,01 natural sciences ,6. Clean water ,Hydrothermal circulation ,chemistry.chemical_compound ,Adsorption ,[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry ,Geochemistry and Petrology ,Zr/Hf ratio ,Economic Geology ,0105 earth and related environmental sciences - Abstract
International audience; We investigated the distribution of Zr, Hf, and rare earth elements (REE) as the sum of lanthanides plus Y in the hydrothermal system in the Lake Van area of south-eastern Turkey. This system is characterised by water with variable pH in alkaline conditions resulting from hydrothermal CO2 upraise and neoformation of calcite minerals in near equilibrium with the interacting waters. Zr, Hf, and REE determinations were carried out for aqueous phases and suspended solids in lake water and surrounding thermal springs. We found that dissolved Hf is partitioned relative to Zr during calcite formation and that such fractionation is a function of the Ca2+ activity in warm water. The observed Zrsingle bondHf fractionation is explained by coulombic interactions that occur between suspended solid particles and dissolved phases at the calcite-water interface. There, the surfaces of carbonate minerals demonstrated greater reactivity towards aqueous Hf-bearing species relative to Zr-complexes. This evidence involves a coulombic mechanism of reactivity at the calcite-water interface because Hf complexes are negatively charged while Zr compounds are uncharged. Thus, authigenic calcite can behave as a suitable host for dissolved metal ion species to adsorb on crystal surfaces to remediate waste waters from mine drainage.
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- 2021
31. Shallow landslide generation at La Fossa cone, Vulcano island (Italy): a multidisciplinary perspective
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Paolo Tommasi, Paolo Madonia, Lucio Olivares, Ygor Oliveri, Sergio Speziale, Marianna Cangemi, Madonia, P., Cangemi, M., Olivares, L., Oliveri, Y., Speziale, S., and Tommasi, P.
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Rainfall ,021110 strategic, defence & security studies ,geography ,geography.geographical_feature_category ,Moisture ,Hydraulic conductivity ,Shallow landslides ,0211 other engineering and technologies ,Landslide ,02 engineering and technology ,Geotechnical Engineering and Engineering Geology ,Hydrothermal circulation ,Hydrothermal alteration ,slope stability ,Permeability (earth sciences) ,Hydraulic conductivity Hydrothermal alteration Shallow landslides Rainfall ,Volcano island ,Volcano ,Soil water ,Water content ,Geomorphology ,Geology ,021101 geological & geomatics engineering - Abstract
Several shallow landslides occurred at La Fossa cone (Vulcano Island, Aeolian Archipelago, Italy) in the last 30 years, during both unrests and periods of quiet volcanic activity. The main event occurred in 1988, during a volcanic unrest, when a landslide collapsed into the sea from the NE flank of La Fossa cone, producing a small tsunami. Hydrothermal activity has been suggested as a potential trigger for landslide generation in this area. However, no specific investigations were carried out to test this hypothesis. With the aim of filling this gap, we studied the mineralogy and hydraulic conductivity of La Fossa cone deposits, the relationships between shallow hydrothermal circulation and rainfall dynamics and their role in triggering slope failures. We also measured rainfall rate, volumetric soil moisture content and soil suction at two automated stations installed in areas with and without active hydrothermal circulation. We found that hydrothermally altered low-conductivity materials show higher background water contents and lower soil suctions than pristine deposits, and their water content is modulated by impulsive increments following rainfalls. This behaviour is due to the combination of lower permeability and direct condensation of hydrothermal vapour. We conclude that shallow hydrothermal circulation produces conditions for slope failures following transients in soil moisture content caused by rainfall infiltration. These considerations allow to identify the areas immediately NW and SE of the 1988 landslide as the most prone to future mass movements.
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- 2019
32. Carbonate precipitation in the alkaline lake Specchio di Venere (Pantelleria Island, Italy) and the possible role of microbial mats
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Ygor Oliveri, Dorothea Hause-Reitner, Marianna Cangemi, Paolo Madonia, Giovannella Pecoraino, Andreas Reimer, Walter D'Alessandro, Paolo Censi, Joachim Reitner, Cangemi, M., Censi, P., Reimer, A., D'Alessandro, W., Hause Reitner, D., Madonia, P., Oliveri, Y., Pecoraino, G., and Reitner, J.
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Mediterranean climate ,010504 meteorology & atmospheric sciences ,δ13C ,Aragonite ,Geochemistry ,Authigenic ,engineering.material ,010502 geochemistry & geophysics ,01 natural sciences ,Pollution ,Diagenesis ,Alkaline lake, Carbonate precipitation, Hydrochemistry, Pantelleria ,chemistry.chemical_compound ,chemistry ,13. Climate action ,Geochemistry and Petrology ,engineering ,Environmental Chemistry ,Carbonate ,14. Life underwater ,Microbial mat ,Hydromagnesite ,Geology ,0105 earth and related environmental sciences - Abstract
Alkaline lakes like the hydrothermally affected lake Specchio di Venere (Pantelleria Island, Central Mediterranean) are typical geological settings harbouring calcified microbial mats. The present work is focused on the discrimination between biotic and abiotic processes driving carbonate precipitation in this lake, using hydrochemical, mineralogical and isotopic data. Hydrochemical analyses demonstrate that the lake is nearly 10−fold supersaturated with regard to aragonite and seasonally reaches hydromagnesite supersaturation. Microscopic observations depict organosedimentary laminated structures consisting of microbial communities and aragonitic precipitates, which are rather disseminated in pores than directly linked to microorganisms. Oxygen isotopic data indicate that authigenic carbonate crystallisation from evaporating water is the dominant precipitation process, further suggested by the absence of textural evidence of diagenetic processes. Conversely, the observed δ13C values reflect an influence of extracellular polymeric substances (EPS) on carbon fractionation during the precipitation process, due to the selective sequestration of 12C in the biomass. The above considerations suggest that at lake Specchio di Venere the carbonate precipitation is mainly of inorganic nature, but a minor role played by biologically influenced processes in microbial mats is not excluded.
- Published
- 2016
33. The behavior of Rare-Earth Elements, Zr and Hf during biologically-mediated deposition of silica-stromatolites and carbonate-rich microbial mats
- Author
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Lorenzo Brusca, Filippo Saiano, Paolo Censi, Pierpaolo Zuddas, Marianna Cangemi, Paolo Madonia, Department of Earth and Marine Sciences, Università di Palermo, I.A.M.C., National Research Council [Italy] (CNR), Istituto Nazionale di Geofisica e Vulcanologia - Sezione di Palermo (INGV), Istituto Nazionale di Geofisica e Vulcanologia, SAF Department, Univesità di Palermo, Institut des Sciences de la Terre de Paris (iSTeP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Palermo - University of Palermo, Censi, P., Cangemi, M., Brusca, L., Madonia, P., Saiano, F., and Zuddas, P.
- Subjects
geochemistry, rare earth elements, Zr/Hf ratio, Silica-stromatolites, Pantelleria Island ,Mineral ,media_common.quotation_subject ,Geochemistry ,[SDU.STU]Sciences of the Universe [physics]/Earth Sciences ,Geology ,Phosphate ,Hydrothermal circulation ,chemistry.chemical_compound ,Speciation ,Deposition (aerosol physics) ,chemistry ,13. Climate action ,Environmental chemistry ,Carbonate ,Seawater ,14. Life underwater ,Microbial mat ,media_common - Abstract
Venere Lake, in the Pantelleria Island thermal system (Central Mediterranean Sea) consists of a mix of seawater and hydrothermal volcanic fluids containing high levels of dissolved SiO 2 . Close to the lake's thermal springs, siliceous stromatolites are deposed under high bacterial activity conditions whereas roughly interlaminated Ca-carbonates and microbial mats are widely scattered in the lake. The dissolved REE speciation in lake waters is dominated by [REE(CO 3 ) 2 ] − , [REE(CO 3 )] + and [REE(H 3 SiO 4 )] 2 + complexes. On the contrary the most abundant Zr and Hf species are hydroxyl- and fluoride-complexes. The behavior of REE Zr and Hf in the Venere lake waters is controlled by precipitation of amorphous silica, carbonates and bacterial activity. Chondrite-normalized REE patterns in stromatolites are characterized by positive La anomalies, superchondritic Y/Ho ratios and negative Eu anomalies. The Eu depletion is also found in microbial mats where is associated to a “chondritic” Y/Ho signature. Zr and Hf differently behave in dissolved phase and in newly-formed siliceous and carbonatic material: Hf reacts easily into amorphous silica surfaces whereas Zr is preferentially partitioned onto phosphate binding sites on microbial cell surfaces similar to the observed behavior of heavy REE (HREE). We suggest that the Zr-Hf relationship reflect the interface processes between mineral phases and bacterial membranes or compounds produced by bacterial activity.
- Published
- 2015
34. Discrimination between effects induced by microbial activity and water-rock interactions under hydrothermal conditions according to REE behaviour
- Author
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Pierpaolo Zuddas, Paolo Madonia, Lorenzo Brusca, Marianna Cangemi, Paolo Censi, Filippo Saiano, Censi, P, Cangemi, M, Madonia, P, Saiano, F, Brusca, L, and Zuddas, P
- Subjects
Rare Earth Elements ,biology ,Rock-water interactions ,Stromatolites ,Bacterial activity ,Rock-water interactions, Hydrothermal system ,Rare earth ,Geochemistry ,Mineralogy ,Earth and Planetary Sciences(all) ,General Medicine ,biology.organism_classification ,Hydrothermal circulation ,Stromatolite ,Rare Earth Element ,Hydrothermal system ,Deposition (aerosol physics) ,Microbial mat ,Geology - Abstract
Rare earth elements (REE) were investigated in siliceous stromatolites forming in the Specchio di Venere Lake on Pantelleria Island. Chondrite-normalised patterns show significant La enrichments and Eu depletions suggesting that fluids involved in stromatolite growth experienced strong rock-water interactions under hydrothermal conditions. At the same time, enrichments in heavy REE (HREE) with respect to intermediate REE (MREE) suggest that hydrothermal fluids interacted with microbial mats during deposition of the stromatolites. The above-mentioned features suggest that rock-water interactions and bacterial activity were simultaneously recorded in the REE patterns of stromatolites, and can be discriminated in terms of amplitudes of the La anomaly, and the HREE/MREE ratio.
- Published
- 2013
35. Geochemistry and mineralogy of sediments and authigenic carbonates from the Malta Plateau, Strait of Sicily (Central Mediterranean): Relationships with mud/fluid release from a mud volcano system
- Author
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Adriana Bellanca, Andrew B. Cundy, Rodolfo Neri, Marianna Cangemi, Massimo Angelone, R. Di Leonardo, Cangemi, M, Di Leonardo, R, Bellanca, A, Cundy, A, Neri, R, and Angelone, M
- Subjects
Methane oxidation ,Geochemistry ,Mineralogy ,engineering.material ,chemistry.chemical_compound ,Mediterranean sea ,Seep carbonate ,Geochemistry and Petrology ,geography ,Plateau ,geography.geographical_feature_category ,δ13C ,Aragonite ,Sediment geochemistry ,Settore GEO/07 - Petrologia E Petrografia ,Geology ,Authigenic ,Stable isotope ,Settore GEO/08 - Geochimica E Vulcanologia ,Strait of Sicily ,chemistry ,Anaerobic oxidation of methane ,engineering ,Carbonate ,Mud volcano - Abstract
A mud volcano field was recently discovered within the Malta Plateau in the Strait of Sicily (Central Mediterranean Sea). Box-core sediments and associated authigenic carbonates have been collected in water depths of 140–170 m from two distinctive sectors of the area, and analyzed for major, trace and rare earth elements, stable isotopes, and mineralogy. Relative homogeneity in the mineralogy and geochemistry of bulk sediments, and 210Pb activity distributions, argue against an active mud ejection activity. In the Malta Plateau western sector, the sediments show high concentrations of Fe, As, Sb, and Mo, exceeding the background values estimated for the Strait of Sicily. Active fluid seepage in this area is thought to be responsible for these enrichments and for the formation of authigenic carbonate crusts. Evidence of bacterial involvement in carbonate (mainly aragonite) formation is recorded in the authigenic crusts, which contain flat and spiralled filaments resembling Beggiatoa-like sulphide oxidising bacteria and biofilm-like remains which occur inside the interspaces. Carbonate crusts consistently show extremely negative δ13C values (down to − 49‰) that suggest contribution of carbon originating from anaerobic methane oxidation. Heavy oxygen isotopic compositions of the authigenic carbonates (2−3‰ higher than those in box-core sediments) are interpreted as due to precipitation from fluids enriched in 18O due to seepage of deep, isotopically-heavy, relict Messinian brines.
- Published
- 2010
36. Geochemistry and petrography of box-core sediments from a methane seep setting in the Strait of Sicily, central Mediterranean
- Author
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CANGEMI, Marianna, DI LEONARDO, Rossella, BELLANCA, Adriana, NERI, Rodolfo, Cangemi, M, Di Leonardo, R, Bellanca, A, and Neri, R
- Subjects
box-core sediment, mud volcano, SE Sicily ,Settore GEO/08 - Geochimica E Vulcanologia - Published
- 2008
37. Biomineralization events in Recent volcanic and sedimentary settings: textural features and isotope signatures
- Author
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CANGEMI, Marianna, BELLANCA, Adriana, NERI, Rodolfo, SCOPELLITI, Giovanna, CANGEMI, M, BELLANCA, A, NERI, R, and SCOPELLITI, G
- Subjects
bacterial activity, siliceous stromatolites, carbonate crusts - Published
- 2008
38. Emerging Role of Immunomonitoring to Predict the Clinical Outcome of Patients With Malignant Pleural Mesothelioma Treated With Radical Radiation Therapy.
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Cangemi M, Montico M, Trovo M, Minatel E, Di Gregorio E, Corona G, Giordari F, Comaro E, Colizzi F, Baboçi L, Steffan A, Revelant A, and Muraro E
- Subjects
- Humans, Mesothelin, Interferon-gamma, Mesothelioma, Malignant, Mesothelioma radiotherapy, Mesothelioma pathology, Lung Neoplasms pathology, Pleural Neoplasms
- Abstract
Purpose: The present study aimed at evaluating the baseline immune profile and the immunomodulating effects of radical hemithoracic radiation therapy (RT) in patients affected by malignant pleural mesothelioma (MPM) to identify potential predictive biomarkers of therapy response, toxicity development, and eligibility for further immunotherapeutic treatments., Methods and Materials: Blood samples were collected from 55 patients with MPM, enrolled in a phase 3 trial comparing radical hemithoracic RT (interventional arm, n = 28) with local palliative RT (control arm, n = 27). Immunomonitoring was performed before RT, at the end of treatment, and 1 month after therapy, characterizing natural killer cells, B and T lymphocytes, activated CD4 and CD8 T cells, interferon-γ- and tumor necrosis factor-α-producing T helper (Th) 1 cells, regulatory T cells, and Th17 and Th22 lymphocytes, through flow cytometry. Serum levels of interleukin (IL)-6, -8, -10 and mesothelin were quantified through Enzyme-Linked Immunosorbent Assay (ELISA) assays at the same time points. Variations in the immune parameters were investigated by Friedman test and Wilcoxon signed rank post hoc test with Bonferroni correction for multiple testing, while the prognostic effect of immune biomarkers was evaluated through Kaplan-Meier method and Spearman's correlation analysis., Results: Major immune variations were noticed after radical RT compared with palliative treatment, in particular an improvement in activated T cells and in interferon-γ-producing Th1 cells after RT. In the interventional arm, baseline high levels of Th22 and IL-10 and an increase in T cells were associated with an improved survival, whereas a fold increase in serum mesothelin correlated with the development of severe toxicity. An improvement of immunosuppressive regulatory T cells was observed in both arms of treatment., Conclusions: The immunomonitoring performed in patients with MPM revealed potential prognostic biomarkers for radical hemithoracic RT treatment and identified specific immune signatures induced by RT immunomodulation, which could suggest a synergistic effect with an immunotherapeutic treatment., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
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39. The volcanic activity changes occurred in the 2021-2022 at Vulcano island (Italy), inferred by the abrupt variations of soil CO 2 output.
- Author
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Inguaggiato S, Vita F, Diliberto IS, Inguaggiato C, Mazot A, Cangemi M, and Corrao M
- Subjects
- Italy, Carbon Dioxide
- Abstract
The active cone of La Fossa is a close conduit volcano characterized by solphataric activity, manifested by discharging fluids through fumaroles and soil degassing. Since 1978 several degassing crises have been observed and interpreted as early signals of volcanic unrests. Recently, from June 2021 to May 2022, we measured the changes in soils CO
2 release to evaluating the level and duration of the actual exhaling crises. The CO2 output has been evaluated by surveys carried out in anomalously degassing areas, located both in the La Fossa cone summit area and in other peripheral zones, coupled to near-real time monitoring data acquired by three automated stations. The strong and deep input of volatiles released from an underlying magma batch modified the chemical composition of the shallow plumbing system, bringing the system to a higher level of CO2 total pressure. This work highlights that a geochemical networks of stations, located at some distance from the fumaroles release and/or from eruptive conduits, is useful and can be applied to characterizing and monitoring any other active volcanic system. This type of studies can be useful to contribute to forecast the next evolution of the studied systems., (© 2022. The Author(s).)- Published
- 2022
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40. Atmospheric Concentration of CO 2 and PM 2.5 at Salina, Stromboli, and Vulcano Islands (Italy): How Anthropogenic Sources, Ordinary Volcanic Activity and Unrests Affect Air Quality.
- Author
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Madonia P, Cangemi M, Colajanni M, and Winkler A
- Subjects
- Carbon Dioxide analysis, Humans, Italy, Particulate Matter, Air Pollution analysis, COVID-19, Groundwater
- Abstract
Geogenic and anthropogenic sources of atmospheric particulate and CO
2 can lead to threats to human health in volcanic areas. Although the volcanic CO2 hazard is a topic frequently debated in the related scientific literature, space and time distribution of PM2.5 are poorly known. The results of combined CO2 /PM2.5 surveys, carried out at Salina, Stromboli, and Vulcano islands (Aeolian archipelago, Italy) in the years 2020-2021, and integrated with investigations on bioaccumulation of metallic particulate matter by the mean of data on the magnetic properties of oleander leaves, are presented in this work. The retrieved results indicate that no significant anthropogenic sources for both CO2 and PM2.5 are active in these islands, at the net of a minor contribution due to vehicular traffic. Conversely, increments in volcanic activity, as the unrest experienced by Vulcano island since the second half of 2021, pose serious threats to human health, due to the near-ground accumulation of CO2 , and the presence of suspended micro-droplets of condensed hydrothermal vapor, fostering the diffusion of atmophile viruses, such as the COVID-19. Gas hazard conditions can be generated, not only by volcanic vents or fumarolic fields, but also by unconventional sources, such as the outgassing from shallow hydrothermal aquifers through drilled or hand-carved wells.- Published
- 2022
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41. Biological Predictors of De Novo Tumors in Solid Organ Transplanted Patients During Oncological Surveillance: Potential Role of Circulating TERT mRNA.
- Author
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Cangemi M, Zanussi S, Rampazzo E, Bidoli E, Giunco S, Tedeschi R, Pratesi C, Martorelli D, Casarotto M, Martellotta F, Schioppa O, Serraino D, Steffan A, De Rossi A, Dolcetti R, and Vaccher E
- Abstract
Background: De novo tumors are a major cause of morbidity and mortality after long-term solid organ transplantation. Chronic immunosuppression strongly affects solid organ transplanted (SOT) patients' immune system by promoting immune evasion strategies and reactivations of viruses with oncogenic potential, ultimately leading to cancer onset. In this scenario, an oncological Surveillance Protocol integrated with biobanking of peripheral blood samples and evaluation of immunovirological and molecular parameters was activated for SOT patients at CRO-IRCCS Aviano, with the aim of identifying suitable biomarkers of cancer development., Methods: An exploratory longitudinal study was designed based on two serial peripheral blood samples collected at least three months apart. Forty nine SOT patients were selected and stratified by tumor onset during follow-up. Spontaneous T-cell responses to EBV, CMV and tumor associated antigens, EBV-DNA and CMV-DNA loads, and circulating TERT mRNA levels were investigated., Results: Significantly higher levels of circulating TERT mRNA were observed 3.5-23.5 months before and close to the diagnosis of cancer as compared to tumor-free patients. Plasmatic TERT mRNA levels >97.73 copies/mL at baseline were significantly associated with the risk of developing de novo tumors (HR=4.0, 95%C.I. = 1.4-11.5, p=0.01). In particular, the risk significantly increased by 4% with every ten-unit increment in TERT mRNA (HR=1.04, 95%C.I. = 1.01-1.07, p=0.01)., Conclusions: Although obtained in an exploratory study, our data support the importance of identifying early biomarkers of tumor onset in SOT patients useful to modulate the pace of surveillance visits., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Cangemi, Zanussi, Rampazzo, Bidoli, Giunco, Tedeschi, Pratesi, Martorelli, Casarotto, Martellotta, Schioppa, Serraino, Steffan, De Rossi, Dolcetti and Vaccher.)
- Published
- 2021
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42. Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis.
- Author
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Paliogiannis P, Mangoni AA, Cangemi M, Fois AG, Carru C, and Zinellu A
- Subjects
- C-Reactive Protein metabolism, COVID-19 blood, Humans, Leukocyte Count, Severity of Illness Index, COVID-19 metabolism, Down-Regulation, Serum Albumin metabolism
- Abstract
Coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for the most threatening pandemic in modern history. The aim of this systematic review and meta-analysis was to investigate the associations between serum albumin concentrations and COVID-19 disease severity and adverse outcomes. A systematic literature search was conducted in PubMed, from inception to October 30, 2020. Sixty-seven studies in 19,760 COVID-19 patients (6141 with severe disease or poor outcome) were selected for analysis. Pooled results showed that serum albumin concentrations were significantly lower in patients with severe disease or poor outcome (standard mean difference, SMD: - 0.99 g/L; 95% CI, - 1.11 to - 0.88, p < 0.001). In multivariate meta-regression analysis, age (t = - 2.13, p = 0.043), publication geographic area (t = 2.16, p = 0.040), white blood cell count (t = - 2.77, p = 0.008) and C-reactive protein (t = - 2.43, p = 0.019) were significant contributors of between-study variance. Therefore, lower serum albumin concentrations are significantly associated with disease severity and adverse outcomes in COVID-19 patients. The assessment of serum albumin concentrations might assist with early risk stratification and selection of appropriate care pathways in this group.
- Published
- 2021
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43. Radical Hemithoracic Radiotherapy Induces Systemic Metabolomics Changes That Are Associated with the Clinical Outcome of Malignant Pleural Mesothelioma Patients.
- Author
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Di Gregorio E, Miolo G, Saorin A, Muraro E, Cangemi M, Revelant A, Minatel E, Trovò M, Steffan A, and Corona G
- Abstract
Radical hemithoracic radiotherapy (RHRT) represents an advanced therapeutic option able to improve overall survival of malignant pleural mesothelioma patients. This study aims to investigate the systemic effects of this radiotherapy modality on the serum metabolome and their potential implications in determining the individual clinical outcome. Nineteen patients undergoing RHRT at the dose of 50 Gy in 25 fractions were enrolled. Serum targeted metabolomics profiles were investigated at baseline and the end of radiotherapy by liquid chromatography and tandem mass spectrometry. Univariate and multivariate OPLS-DA analyses were applied to study the serum metabolomics changes induced by RHRT while PLS regression analysis to evaluate the association between such changes and overall survival. RHRT was found to affect almost all investigated metabolites classes, in particular, the amino acids citrulline and taurine, the C14, C18:1 and C18:2 acyl-carnitines as well as the unsaturated long chain phosphatidylcholines PC ae 42:5, PC ae 44:5 and PC ae 44:6 were significantly decreased. The enrichment analysis showed arginine metabolism and the polyamine biosynthesis as the most perturbed pathways. Moreover, specific metabolic changes encompassing the amino acids and acyl-carnitines resulted in association with the clinical outcome accounting for about 60% of the interpatients overall survival variability. This study highlighted that RHRT can induce profound systemic metabolic effects some of which may have a significant prognostic value. The integration of metabolomics in the clinical assessment of the malignant pleural mesothelioma could be useful to better identify the patients who can achieve the best benefit from the RHRT treatment.
- Published
- 2021
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44. Clinical and Antitumor Immune Responses in Relapsed/Refractory Follicular Lymphoma Patients after Intranodal Injections of IFNα-Dendritic Cells and Rituximab: a Phase I Clinical Trial.
- Author
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Cox MC, Castiello L, Mattei M, Santodonato L, D'Agostino G, Muraro E, Martorelli D, Lapenta C, Di Napoli A, Di Landro F, Cangemi M, Pavan A, Castaldo P, Hohaus S, Donati S, Montefiore E, Berdini C, Carlei D, Monque DM, Ruco L, Prosperi D, Tafuri A, Spadaro F, Sestili P, Spada M, Dolcetti R, Santini SM, Rozera C, Aricò E, Capone I, and Belardelli F
- Subjects
- Adult, Aged, Animals, Antineoplastic Agents, Immunological administration & dosage, Combined Modality Therapy, Dendritic Cells drug effects, Dendritic Cells immunology, Drug Resistance, Neoplasm, Female, Granulocyte-Macrophage Colony-Stimulating Factor pharmacology, Humans, Injections, Intralymphatic, Interferon-alpha pharmacology, Lymphoma, Follicular immunology, Lymphoma, Follicular pathology, Male, Mice, Mice, Inbred NOD, Mice, SCID, Middle Aged, Neoplasm Recurrence, Local immunology, Neoplasm Recurrence, Local pathology, Remission Induction, Salvage Therapy, Xenograft Model Antitumor Assays, Dendritic Cells transplantation, Immunotherapy, Adoptive methods, Lymphoma, Follicular therapy, Neoplasm Recurrence, Local therapy, Rituximab administration & dosage
- Abstract
Purpose: This study was aimed at evaluating the feasibility, safety, immunologic and clinical responses in patients with follicular lymphoma treated with monocyte-derived dendritic cells generated in the presence of IFNα and GM-CSF (IFN-DC) in combination with low doses of rituximab., Patients and Methods: Firstly, we analyzed in vitro and in vivo the immunologic properties of IFN-DC against follicular lymphoma. Thus, we performed a phase I trial in 8 patients with refractory and relapsed follicular lymphoma based on sequential intranodal injections of low-dose of rituximab and unloaded IFN-DC and report the safety, clinical, and immunologic results of the enrolled patients., Results: Preclinical studies indicated that IFN-DC can synergize with rituximab leading to increased cytotoxicity and T-cell tumor infiltration. The clinical evaluation showed that the combined treatment was totally safe. The overall response rate was 50%, PET-negative complete response rate 37%, and remission is still ongoing in 2/4 of responding patients (median follow-up 26 months, range 11-47). Notably, following the combined therapy all patients showed induction/enhancement of T-cell responses by CD107 degranulation or IFNγ ELISPOT assay against patient-specific tumor IGHV sequences., Conclusions: These results represent the proof-of-principle on the effectiveness of unloaded IFN-DC in inducing durable clinical responses and promoting induction of tumor-specific peripheral T cells, thus suggesting the occurrence of an effective endogenous antitumor vaccination. The overall findings indicate that some unique properties of IFN-DC can be successfully exploited to induce/enhance antitumor responses, thus representing a valuable antitumor strategy for novel and more effective combination therapies in patients with cancer., (©2019 American Association for Cancer Research.)
- Published
- 2019
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45. Dissecting the Multiplicity of Immune Effects of Immunosuppressive Drugs to Better Predict the Risk of de novo Malignancies in Solid Organ Transplant Patients.
- Author
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Cangemi M, Montico B, Faè DA, Steffan A, and Dolcetti R
- Abstract
De novo malignancies constitute an emerging cause of morbidity after solid organ transplant (SOT), significantly affecting the long-term survival of transplant recipients. Pharmacologic immunosuppression may functionally impair the immunosurveillance in these patients, thereby increasing the risk of cancer development. Nevertheless, the multiplicity and heterogeneity of the immune effects induced by immunosuppressive drugs limit the current possibilities to reliably predict the risk of de novo malignancy in SOT patients. Therefore, there is the pressing need to better characterize the immune dysfunctions induced by the different immunosuppressive regimens administered to prevent allograft rejection to tailor more precisely the therapeutic schedule and decrease the risk of de novo malignancies. We herein highlight the impact exerted by different classes of immunosuppressants on the most relevant immune cells, with a particular focus on the effects on dendritic cells (DCs), the main regulators of the balance between immunosurveillance and tolerance.
- Published
- 2019
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46. Heavy Metal Concentrations in the Groundwater of the Barcellona-Milazzo Plain (Italy): Contributions from Geogenic and Anthropogenic Sources.
- Author
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Cangemi M, Madonia P, Albano L, Bonfardeci A, Di Figlia MG, Di Martino RMR, Nicolosi M, and Favara R
- Subjects
- Agriculture, Environmental Monitoring methods, Humans, Italy, Water Wells, Groundwater chemistry, Metals, Heavy analysis, Water Pollutants, Chemical analysis
- Abstract
We collected and analysed 58 samples of groundwater from wells in the Barcellona-Milazzo Plain, one of the most important coastal aquifers of Sicily (Italy), to determine major, minor, and trace element concentrations. In this area, geogenic and anthropogenic sources of heavy metals and other pollutants co-act, making the individuation of the main pollution sources difficult. Our work was aimed at the application of geostatistical criteria for discriminating between these pollution sources. We used probability plots for separating anomalous values from background concentrations, which were plotted on maps and related to possible sources of pollutants. Our results indicate that hydrothermal fluid circulation and the water⁻rock interaction of country rocks that host mineralized ore deposits generate a significant flux of heavy metals to groundwater, as well as anthropogenic sources like intense agriculture and industrial activities. In particular, NO₃, F, and Ni exceed the Maximum Admitted Concentrations (MACs) established by the WHO and Italian legislation for drinking-water. The spatial distributions of geogenic and anthropogenic sources were so deeply interlocked that their separation was not easy, also employing geostatistical tools. This complex scenario makes the implementation of human health risk mitigation actions difficult, since the flow of pollutants is in many cases controlled by simple water⁻rock interaction processes.
- Published
- 2019
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47. Cytokine-Induced Killer Cells Kill Chemo-surviving Melanoma Cancer Stem Cells.
- Author
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Gammaitoni L, Giraudo L, Macagno M, Leuci V, Mesiano G, Rotolo R, Sassi F, Sanlorenzo M, Zaccagna A, Pisacane A, Senetta R, Cangemi M, Cattaneo G, Martin V, Coha V, Gallo S, Pignochino Y, Sapino A, Grignani G, Carnevale-Schianca F, Aglietta M, and Sangiolo D
- Subjects
- Animals, Carcinogenesis genetics, Carcinogenesis immunology, Cell Line, Tumor, Cytokine-Induced Killer Cells immunology, Drug Resistance, Neoplasm genetics, Drug Resistance, Neoplasm immunology, Humans, Imidazoles administration & dosage, Lentivirus genetics, Melanoma drug therapy, Melanoma immunology, Melanoma pathology, Mice, Neoplasm Recurrence, Local, Neoplastic Stem Cells immunology, Neoplastic Stem Cells transplantation, Nitrosourea Compounds administration & dosage, Organophosphorus Compounds administration & dosage, Oximes administration & dosage, Proto-Oncogene Proteins B-raf antagonists & inhibitors, Proto-Oncogene Proteins B-raf genetics, Xenograft Model Antitumor Assays, Cytokine-Induced Killer Cells transplantation, Cytotoxicity, Immunologic, Immunotherapy, Adoptive methods, Melanoma therapy
- Abstract
Purpose: The MHC-unrestricted activity of cytokine-induced killer (CIK) cells against chemo-surviving melanoma cancer stem cells (mCSC) was explored, as CSCs are considered responsible for chemoresistance and relapses. Experimental Design: Putative mCSCs were visualized by engineering patient-derived melanoma cells (MC) with a lentiviral vector encoding eGFP under expression control by stemness gene promoter oct4 Their stemness potential was confirmed in vivo by limiting dilution assays. We explored the sensitivity of eGFP
+ mCSCs to chemotherapy (CHT), BRAF inhibitor (BRAFi) or CIK cells, as single agents or in sequence, in vitro First, we treated MCs in vitro with fotemustine or dabrafenib (BRAF-mutated cases); then, surviving MCs, enriched in mCSCs, were challenged with autologous CIK cells. CIK cell activity against chemoresistant mCSCs was confirmed in vivo in two distinct immunodeficient murine models. Results: We visualized eGFP+ mCSCs (14% ± 2.1%) in 11 MCs. The tumorigenic precursor rate in vivo was higher within eGFP+ MCs (1/42) compared with the eGFP- counterpart (1/4,870). In vitro mCSCs were relatively resistant to CHT and BRAFi, but killed by CIK cells ( n = 11, 8/11 autologous), with specific lysis ranging from 95% [effector:tumor ratio (E:T), 40:1] to 20% (E:T 1:3). In vivo infusion of autologous CIK cells into mice bearing xenografts from three distinct melanomas demonstrated significant tumor responses involving CHT-spared eGFP+ mCSCs ( P = 0.001). Sequential CHT-immunotherapy treatment retained antitumor activity ( n = 12, P = 0.001) reducing mCSC rates ( P = 0.01). Conclusions: These findings are the first demonstration that immunotherapy with CIK cells is active against autologous mCSCs surviving CHT or BRAFi. An experimental platform for mCSC study and rationale for CIK cells in melanoma clinical study is provided. Clin Cancer Res; 23(9); 2277-88. ©2016 AACR ., (©2016 American Association for Cancer Research.)- Published
- 2017
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48. Fighting Viral Infections and Virus-Driven Tumors with Cytotoxic CD4 + T Cells.
- Author
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Muraro E, Merlo A, Martorelli D, Cangemi M, Dalla Santa S, Dolcetti R, and Rosato A
- Abstract
CD4
+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and specific functions. Nonetheless, a growing body of evidence indicates that CD4+ T cells can also exert a direct effector activity, which depends on intrinsic cytotoxic properties acquired and carried out along with the evolution of several pathogenic infections. The relevant role of CD4+ T cell lytic features in the control of such infectious conditions also leads to their exploitation as a new immunotherapeutic approach. This review aims at summarizing currently available data about functional and therapeutic relevance of cytotoxic CD4+ T cells in the context of viral infections and virus-driven tumors.- Published
- 2017
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49. Adoptive immunotherapy against sarcomas.
- Author
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Mesiano G, Leuci V, Giraudo L, Gammaitoni L, Carnevale Schianca F, Cangemi M, Rotolo R, Capellero S, Pignochino Y, Grignani G, Aglietta M, and Sangiolo D
- Subjects
- Animals, Cytokine-Induced Killer Cells immunology, Cytokine-Induced Killer Cells transplantation, Cytokines immunology, Humans, Immunotherapy, Adoptive trends, Sarcoma diagnosis, T-Lymphocytes immunology, T-Lymphocytes transplantation, Immunotherapy, Adoptive methods, Sarcoma immunology, Sarcoma therapy
- Abstract
Introduction: Conventional treatments reached an unsatisfactory therapeutic plateau in the treatment of advanced unresectable bone and soft tissue sarcomas that remain an unsolved medical need. Several evidences support the concept that adoptive immunotherapy may effectively integrate within the complex and multidisciplinary treatment of sarcomas., Areas Covered: In this work we reviewed adoptive immunotherapy strategies that have been explored in sarcoma settings, with specific focus on issues related to their clinic transferability. We schematically divided approaches based on T lymphocytes specific for MHC-restricted tumor-associated antigens or relying on MHC-independent immune effectors such as natural killer (NK), cytokine-induced killer (CIK) or γδ T cells., Expert Opinion: Preclinical findings and initial clinical reports showed the potentialities and drawbacks of different adoptive immunotherapy strategies. The expansion of tumor infiltrating lymphocytes is difficult to be reproduced outside melanoma. Genetically redirected T cells appear to be a promising option and initial reports are encouraging against patients with sarcomas. Adoptive immunotherapy with MHC-unrestricted effectors such as NK, CIK or γδ T cells has recently shown great preclinical potential in sarcoma setting and biologic features that may favor clinical transferability. Combination of different immunotherapy approaches and integration with conventional treatments appear to be key issues for successful designing of next clinical trials.
- Published
- 2015
- Full Text
- View/download PDF
50. Cytokine-induced killer cells as immunotherapy for solid tumors: current evidence and perspectives.
- Author
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Giraudo L, Gammaitoni L, Cangemi M, Rotolo R, Aglietta M, and Sangiolo D
- Subjects
- Animals, Clinical Trials as Topic, Cytokine-Induced Killer Cells transplantation, Disease Models, Animal, Humans, Neoplasms immunology, Cytokine-Induced Killer Cells immunology, Immunotherapy, Adoptive, NK Cell Lectin-Like Receptor Subfamily K metabolism, Neoplasms therapy
- Abstract
Cytokine-induced killer (CIK) cells are ex vivo expanded T lymphocytes endowed with potent MHC-independent antitumor activity. CIK cells are emerging as promising therapeutic approach in the field of cancer adoptive immunotherapy, with biologic features favoring their transferability into clinical applications. Aim of this review is to present the biologic characteristic of CIK cells, discussing the main preclinical findings and initial clinical applications in the field of solid tumors.
- Published
- 2015
- Full Text
- View/download PDF
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