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5. Hypoalbuminemia and Risk of Portal Vein Thrombosis in Cirrhosis

Author

Giuseppe, Palasciano, Felicia, D’Alitto, Ostilio, Palmieri Vincenzo, Daniela, Santovito, Dario, Di Michele, Giuseppe, Croce, David, Sacerdoti, Silvia, Brocco, Silvano, Fasolato, Lara, Cecchetto, Giancarlo, Bombonato, Michele, Bertoni, Tea, Restuccia, Paola, Andreozzi, Livia, Liguori Maria, Francesco, Perticone, Benedetto, Caroleo, Maria, Perticone, Orietta, Staltari, Roberto, Manfredini, Alfredo, De Giorgi, Maurizio, Averna, Antonina, Giammanco, Alessandro, Granito, Irene, Pettinari, Sara, Marinelli, Luigi, Bolondi, Lorenzo, Falsetti, Aldo, Salvi, Emanuele, Durante-Mangoni, Flavio, Cesaro, Vincenza, Farinaro, Enrico, Ragone, Ignazio, Morana, Angelo, Andriulli, Antonio, Ippolito, Angelo, Iacobellis, Grazia, Niro, Antonio, Merla, Giovanni, Raimondo, Sergio, Maimone, Irene, Cacciola, Doriana, Varvara, Davide, Drenaggi, Silvia, Staffolani, Antonio, Picardi, Umberto, Vespasiani-Gentilucci, Giovanni, Galati, Paolo, Gallo, Giovanni, Davì, Cosima, Schiavone, Francesca, Santilli, Claudio, Tana, Anna, Licata, Maurizio, Soresi, Battista, Bianchi Giovanni, Isabella, Carderi, Antonio, Pinto, Antonino, Tuttolomondo, Giovanni, Ferrari, Paolo, Gresele, Tiziana, Fierro, Olivia, Morelli, Giacomo, Laffi, Giulio, Romanelli Roberto, Umberto, Arena, Cristina, Stasi, Antonio, Gasbarrini, Matteo, Gargovich, Assunta, Zocco Maria, Laura, Riccardi, Elena, Ainora Maria, William, Capeci, Pio, Martino Giuseppe, Lorenzo, Nobili, Maurizio, Cavallo, Pierluigi, Frugiuele, Antonio, Greco, Antonello, Pietrangelo, Paolo, Ventura, Chiara, Cuoghi, Matteo, Marcacci, Gaetano, Serviddio, Gianluigi, Vendemiale, Rosanna, Villani, Ruggiero, Gargano, Gianpaolo, Vidili, Valentina, Di Cesare, Maristella, Masala, Giuseppe, Delitala, Pietro, Invernizzi, Giovanni, Di Minno, Antonella, Tufano, Francesco, Purrello, Graziella, Privitera, Alessandra, Forgione, Valentina, Curigliano, Marco, Senzolo, Kryssia Isabel, Rodríguez-Castro, Gianluigi, Giannelli, Carla, Serra, Sergio, Neri, Pietro, Pignataro, Mario, Rizzetto, Wilma, Debernardi Venon, Gianluca, Svegliati Baroni, Gaetano, Bergamaschi, Michela, Masotti, Filippo, Costanzo, Roberto, Corazza Gino, Hugh, Caldwell Stephen, Francesco, Angelico, Ben Maria, Del, Laura, Napoleone, Licia, Polimeni, Marco, Proietti, Valeria, Raparelli, Francesco, Romiti Giulio, Eleonora, Ruscio, Andrea, Severoni, Giovanni, Talerico, Filippo, Toriello, Annarita, Vestri, Cangemi, Roberto, Raparelli, Valeria, Talerico, Giovanni, Basili, Stefania, and Violi, Francesco

Published
2024
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6. Association between PaO2/FiO2 ratio and thrombotic events in COVID-19 patients

Author

Loffredo, Lorenzo, Pignatelli, Pasquale, Pirro, Matteo, Ceccarelli, Giancarlo, Oliva, Alessandra, Maggio, Enrico, Cancelli, Francesca, D’Ardes, Damiano, Amitrano, Maria, Zicari, Anna Maria, Cinicola, Bianca Laura, Taliani, Gloria, Cangemi, Roberto, Lichtner, Miriam, Falcone, Marco, Orlando, Federica, Pugliese, Francesco, Venditti, Mario, Mastroianni, Claudio Maria, and Violi, Francesco

Published
2023
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8. Breakthrough infections after COVID-19 vaccinations do not elicit platelet hyperactivation and are associated with high platelet–lymphocyte and low platelet–neutrophil aggregates

Author

Maiorca, Francesca, Lombardi, Ludovica, Marrapodi, Ramona, Pallucci, Davide, Sabetta, Annamaria, Zingaropoli, Maria Antonella, Perri, Valentina, Flego, Davide, Romiti, Giulio Francesco, Corica, Bernadette, Miglionico, Marzia, Russo, Gianluca, Pasculli, Patrizia, Ciardi, Maria Rosa, Mastroianni, Claudio M., Ruberto, Franco, Pugliese, Francesco, Pulcinelli, Fabio, Raparelli, Valeria, Cangemi, Roberto, Visentini, Marcella, Basili, Stefania, and Stefanini, Lucia

Published
2023
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9. Endothelial dysfunction, oxidative stress and low-grade endotoxemia in COVID-19 patients hospitalised in medical wards

Author

Ciacci, Paolo, Paraninfi, Aurora, Orlando, Federica, Rella, Silvia, Maggio, Enrico, Oliva, Alessandra, Cangemi, Roberto, Carnevale, Roberto, Bartimoccia, Simona, Cammisotto, Vittoria, D'Amico, Alessandra, Magna, Arianna, Nocella, Cristina, Mastroianni, Claudio Maria, Pignatelli, Pasquale, Violi, Francesco, and Loffredo, Lorenzo

Published
2023
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15. Association Between NOX2-Mediated Oxidative Stress, Low-Grade Endotoxemia, Hypoalbuminemia, and Clotting Activation in COVID-19.

Author

Carnevale, Roberto, Nocella, Cristina, Marocco, Raffaella, Zuccalà, Paola, Carraro, Anna, Picchio, Vittorio, Oliva, Alessandra, Cangemi, Roberto, Miele, Maria Claudia, De Angelis, Massimiliano, Cancelli, Francesca, Casciaro, Giovanni Enrico, Cristiano, Luca, Pignatelli, Pasquale, Frati, Giacomo, Venditti, Mario, Pugliese, Francesco, Mastroianni, Claudio Maria, Violi, Francesco, and Ridola, Lorenzo

Subjects
COVID-19, ADULT respiratory distress syndrome, ENDOTOXEMIA, SERUM albumin, BLOOD coagulation, ALBUMINS
Abstract

Low-grade endotoxemia by lipopolysaccharide (LPS) has been detected in COVID-19 and could favor thrombosis via eliciting a pro-inflammatory and pro-coagulant state. The aim of this study was to analyze the mechanism accounting for low-grade endotoxemia and its relationship with oxidative stress and clotting activation thrombosis in COVID-19. We measured serum levels of sNOX2-dp, zonulin, LPS, D-dimer, and albumin in 175 patients with COVID-19, classified as having or not acute respiratory distress syndrome (ARDS), and 50 healthy subjects. Baseline levels of sNOX2-dp, LPS, zonulin, D-dimer, albumin, and hs-CRP were significantly higher in COVID-19 compared to controls. In COVID-19 patients with ARDS, sNOX2-dp, LPS, zonulin, D-dimer, and hs-CRP were significantly higher compared to COVID-19 patients without ARDS. Conversely, concentration of albumin was lower in patients with ARDS compared with those without ARDS and inversely associated with LPS. In the COVID-19 cohort, the number of patients with ARDS progressively increased according to sNOX2-dp and LPS quartiles; a significant correlation between LPS and sNOX2-dp and LPS and D-dimer was detected in COVID-19. In a multivariable logistic regression model, LPS/albumin levels and D-dimer predicted thrombotic events. In COVID-19 patients, LPS is significantly associated with a hypercoagulation state and disease severity. In vitro, LPS can increase endothelial oxidative stress and coagulation biomarkers that were reduced by the treatment with albumin. In conclusion, impaired gut barrier permeability, increased NOX2 activation, and low serum albumin may account for low-grade endotoxemia and may be implicated in thrombotic events in COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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16. A Focus on the Pathophysiology of Adrenomedullin Expression: Endothelitis and Organ Damage in Severe Viral and Bacterial Infections

Author

Spoto, Silvia, primary, Basili, Stefania, additional, Cangemi, Roberto, additional, Yuste, José Ramón, additional, Lucena, Felipe, additional, Romiti, Giulio Francesco, additional, Raparelli, Valeria, additional, Argemi, Josepmaria, additional, D’Avanzo, Giorgio, additional, Locorriere, Luciana, additional, Masini, Francesco, additional, Calarco, Rodolfo, additional, Testorio, Giulia, additional, Spiezia, Serenella, additional, Ciccozzi, Massimo, additional, and Angeletti, Silvia, additional

Published
2024
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17. NOX2 as a Biomarker of Academic Performance: Evidence from University Students during Examination

Author

Nocella, Cristina, primary, D’Amico, Alessandra, additional, Cangemi, Roberto, additional, Fossati, Chiara, additional, Pigozzi, Fabio, additional, Mannacio, Elena, additional, Cammisotto, Vittoria, additional, Bartimoccia, Simona, additional, Castellani, Valentina, additional, Sarto, Gianmarco, additional, Simeone, Beatrice, additional, Rocco, Erica, additional, Frati, Giacomo, additional, Sciarretta, Sebastiano, additional, Pignatelli, Pasquale, additional, Carnevale, Roberto, additional, and SMiLe Group, SMiLe Group, additional

Published
2024
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21. Prediction of new-onset atrial fibrillation with the C2HEST score in patients admitted with community-acquired pneumonia.

Author

Pastori, Daniele, Menichelli, Danilo, Romiti, Giulio Francesco, Speziale, Angela Pia, Pignatelli, Pasquale, Basili, Stefania, Violi, Francesco, and Cangemi, Roberto

Subjects
ATRIAL fibrillation risk factors, PREDICTIVE tests, RISK assessment, RECEIVER operating characteristic curves, HOSPITAL care, MULTIPLE regression analysis, HYPERTENSION, PROBABILITY theory, MULTIVARIATE analysis, DESCRIPTIVE statistics, HEART failure, SEVERITY of illness index, COMMUNITY-acquired pneumonia, LONGITUDINAL method, HYPERTHYROIDISM, STROKE, CONFIDENCE intervals, COMPARATIVE studies, PROPORTIONAL hazards models, TRANSIENT ischemic attack, SENSITIVITY & specificity (Statistics), DISEASE complications
Abstract

Purpose: Patients hospitalized for community-acquired pneumonia (CAP) may have a higher risk of new-onset atrial fibrillation (NOAF). The C2HEST score was developed to evaluate the NOAF risk in the general population. Data on the value of the C2HEST score in acute patients admitted with CAP are lacking. We want to establish the predictive value of C2HEST score for NOAF in patients with CAP. Methods: Patients with CAP enrolled in the SIXTUS cohort were enrolled. C2HEST score was calculated at baseline. In-hospital NOAF was recorded. Receiver-operating Characteristic (ROC) curve and multivariable Cox proportional hazard regression analysis were performed. Results: We enrolled 473 patients (36% women, mean age 70.6 ± 16.5 years), and 54 NOAF occurred. Patients with NOAF were elderly, more frequently affected by hypertension, heart failure, previous stroke/transient ischemic attack, peripheral artery disease and hyperthyroidism. NOAF patients had also higher CURB-65, PSI class and CHA2DS2-VASc score. The C-index of C2HEST score for NOAF was 0.747 (95% confidence interval [95%CI] 0.705–0.786), higher compared to CURB-65 (0.611, 95%CI 0.566–0.655, p = 0.0016), PSI (0.665, 95%CI 0.621–0.708, p = 0.0199) and CHA2DS2-VASc score (0.696, 95%CI 0.652–0.737, p = 0.0762). The best combination of sensitivity (67%) and specificity (70%) was observed with a C2HEST score ≥ 4. This result was confirmed by the multivariable Cox analysis (Hazard Ratio [HR] for C2HEST score ≥ 4 was 10.7, 95%CI 2.0–57.9; p = 0.006), independently from the severity of pneumonia. Conclusion: The C2HEST score was a useful predictive tool to identify patients at higher risk for NOAF during hospitalization for CAP. Clinical Trial Registration: www.clinicaltrials.gov (NCT01773863) [ABSTRACT FROM AUTHOR]

Published
2024
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22. Mid-Regional Pro-Adrenomedullin Can Predict Organ Failure and Prognosis in Sepsis?

Author

Spoto, Silvia, primary, Basili, Stefania, additional, Cangemi, Roberto, additional, D’Avanzo, Giorgio, additional, Lupoi, Domenica Marika, additional, Romiti, Giulio Francesco, additional, Argemi, Josepmaria, additional, Yuste, José Ramón, additional, Lucena, Felipe, additional, Locorriere, Luciana, additional, Masini, Francesco, additional, Testorio, Giulia, additional, Calarco, Rodolfo, additional, Fogolari, Marta, additional, Francesconi, Maria, additional, Battifoglia, Giulia, additional, Costantino, Sebastiano, additional, and Angeletti, Silvia, additional

Published
2023
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26. Reply to Frencken et al

Author

SIXTUS Study Group, Violi, Francesco, Cangemi, Roberto, Farcomeni, Alessio, and Corrales-Medina, Vicente F.

Published
2017

28. Neutrophil Cathepsin G and Thrombosis in COVID-19.

Author

Violi, Francesco, Bartimoccia, Simona, Cangemi, Roberto, Nocella, Cristina, D'Amico, Alessandra, Oliva, Alessandra, Venditti, Mario, Pugliese, Francesco, Mastroianni, Claudio Maria, Ridola, Lorenzo, Lichtner, Miriam, Cardinale, Vincenzo, Alvaro, Domenico, Cammisotto, Vittoria, Castellani, Valentina, Pignatelli, Pasquale, and Carnevale, Roberto

Published
2024
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30. Mid-Regional Pro-Adrenomedullin and N-Terminal Pro-B-Type Natriuretic Peptide Measurement: A Multimarker Approach to Diagnosis and Prognosis in Acute Heart Failure

Author

Spoto, Silvia, primary, Argemi, Josepmaria, additional, Di Costanzo, Roberta, additional, Gavira Gomez, Juan Josè, additional, Gonzales, Salterain, additional, Basili, Stefania, additional, Cangemi, Roberto, additional, Abbate, Antonio, additional, Locorriere, Luciana, additional, Masini, Francesco, additional, Testorio, Giulia, additional, Calarco, Rodolfo, additional, Battifoglia, Giulia, additional, Mangiacapra, Fabio, additional, Fogolari, Marta, additional, Costantino, Sebastiano, additional, and Angeletti, Silvia, additional

Published
2023
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31. Platelets from patients with decompensated cirrhosis display pro-inflammatory features

Author

Di Cola, Simone, primary, Stefanini, Lucia, additional, Lombardi, Ludovica, additional, Fonte, Stefano, additional, Maiorca, Francesca, additional, Pallucci, Davide, additional, Marrapodi, Ramona, additional, Sabetta, Annamaria, additional, Miglionico, Marzia, additional, Cangemi, Roberto, additional, Visentini, Marcella, additional, Riggio, Oliviero, additional, Merli, Manuela, additional, and Basili, Stefania, additional

Published
2023
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32. Impaired flow-mediated dilation in hospitalized patients with community-acquired pneumonia

Author

Loffredo, Lorenzo, Cangemi, Roberto, Perri, Ludovica, Catasca, Elisa, Calvieri, Camilla, Carnevale, Roberto, Nocella, Cristina, Equitani, Francesco, Ferro, Domenico, Violi, Francesco, Battaglia, Simona, Bertazzoni, Giuliano, Biliotti, Elisa, Bucci, Tommaso, Calabrese, Cinzia Myriam, Casciaro, Marco, Celestini, Andrea, De Angelis, Maurizio, De Marzio, Paolo, Esvan, Rozenn, Falcone, Marco, Fazi, Lucia, Sulekova, Lucia Fontanelli, Franchi, Cristiana, Giordo, Laura, Grieco, Stefania, Manzini, Elisa, Marinelli, Paolo, Mordenti, Michela, Morelli, Sergio, Palange, Paolo, Pastori, Daniele, Pignatelli, Pasquale, Capparuccia, Marco Rivano, Romiti, Giulio Francesco, Rossi, Elisabetta, Ruscio, Eleonora, Russo, Alessandro, Scarpellini, Maria Gabriella, Solimando, Luisa, Taliani, Gloria, Trapè, Stefano, and Toriello, Filippo

Published
2016
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33. Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study

Author

Raparelli, Valeria, Pastori, Daniele, Pignataro, Serena Francesca, Vestri, Anna Rita, Pignatelli, Pasquale, Cangemi, Roberto, Proietti, Marco, Davì, Giovanni, Hiatt, William Robert, Lip, Gregory Yoke Hong, Corazza, Gino Roberto, Perticone, Francesco, Violi, Francesco, Basili, Stefania, and ARAPACIS Study Collaborators

Published
2018
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36. Relation of Cardiac Complications in the Early Phase of Community-Acquired Pneumonia to Long-Term Mortality and Cardiovascular Events

Author

Battaglia, Simona, Biliotti, Elisa, Calabrese, Cinzia M., Casciaro, Marco, De Angelis, Maurizio, De Marzio, Paolo, Esvan, Rozenn, Fazi, Lucia, Sulekova, Lucia F., Franchi, Cristiana, Giordo, Laura, Grieco, Stefania, Manzini, Elisa, Marinelli, Paolo, Mordenti, Michela, Morelli, Sergio, Palange, Paolo, Pastori, Daniele, Pignatelli, Pasquale, Capparuccia, Marco R., Romiti, Giulio F., Rossi, Elisabetta, Ruscio, Eleonora, Russo, Alessandro, Solimando, Luisa, Trapè, Stefano, Toriello, Filippo, Cangemi, Roberto, Calvieri, Camilla, Falcone, Marco, Bucci, Tommaso, Bertazzoni, Giuliano, Scarpellini, Maria G., Barillà, Francesco, Taliani, Gloria, and Violi, Francesco

Published
2015
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39. Platelet Activation Is Associated With Myocardial Infarction in Patients With Pneumonia

Author

Albanese, Fabiana, Biliotti, Elisa, Carnevale, Roberto, Catasca, Elisa, Celestini, Andrea, Esvan, Rozenn, Fazi, Lucia, Marinelli, Paolo, Mordenti, Michela, Napoleone, Laura, Palumbo, Michela, Pastori, Daniele, Perri, Ludovica, Proietti, Marco, Capparuccia Marco, Rivano, Russo, Alessandro, Russo, Roberta, Sarallo, Valentino, Salvatori, Gabriele, Scarpellini, Maria Gabriella, Ullo, Ines, Cangemi, Roberto, Casciaro, Marco, Rossi, Elisabetta, Calvieri, Camilla, Bucci, Tommaso, Calabrese, Cinzia Myriam, Taliani, Gloria, Falcone, Marco, Palange, Paolo, Bertazzoni, Giuliano, Farcomeni, Alessio, Grieco, Stefania, Pignatelli, Pasquale, and Violi, Francesco

Published
2014
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40. Adherence to the Mediterranean Diet in Preventing Major Cardiovascular Events in Patients with Ischemic Heart Disease: The EVA Study.

Author

Cangemi, Roberto, Miglionico, Marzia, D'Amico, Tania, Fasano, Salvatore, Proietti, Marco, Romiti, Giulio Francesco, Corica, Bernadette, Stefanini, Lucia, Tanzilli, Gaetano, Basili, Stefania, Raparelli, Valeria, and Tarsitano, Maria Grazia

Abstract

Background: Adherence to healthy dietary patterns, such as the Mediterranean diet (Med-diet), is recommended for the maintenance of cardiovascular health. The determinants for adherence to Med-diet and its importance in secondary cardiovascular disease prevention are still unclear. The aim of the study was to evaluate the influence of sex- and psycho-socio-cultural (i.e., gender-related) factors on Med-diet adherence and its role in preventing major cardiovascular events (MACEs) in patients with ischemic heart disease (IHD). Methods: Med-diet adherence was evaluated among 503 consecutive adults with IHD. MACEs were collected during a long-term follow-up. Results: Male Bem Sex-Role Inventory score (i.e., male personality traits) and physical functional capacity were associated with higher adherence, while cohabitation with a smoker and physical inactivity with poorer adherence. During a median follow-up of 22 months, 48 participants experienced MACEs (17.5%, 8.1%, and 3.9% of patients with low, medium, and high adherence, respectively; p = 0.016). At multivariate Cox--regression analysis, a greater adherence remained inversely associated with MACEs (HR: 0.49; 95% CI: 0.29–0.82; p = 0.006) after adjusting for confounding factors. Conclusion: The study suggests that gender-related factors have a role in maintaining a healthy dietary pattern. Improving Med-diet adherence may lower the risk of recurring cardiovascular events. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Cholesterol-adjusted vitamin E serum levels are associated with cardiovascular events in patients with non-valvular atrial fibrillation

Author

Cangemi, Roberto, Pignatelli, Pasquale, Carnevale, Roberto, Corazza, Gino Roberto, Pastori, Daniele, Farcomeni, Alessio, Basili, Stefania, Davì, Giovanni, Ferro, Domenico, Hiatt, William R., Licata, Giuseppe, Lip, Gregory Y.H., Loffredo, Lorenzo, Mannucci, Pier Mannuccio, Vestri, Annarita, and Violi, Francesco

Published
2013
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45. Association between PaO2/FiO2 ratio and thrombotic events in COVID-19 patients.

Author

Loffredo, Lorenzo, Pignatelli, Pasquale, Pirro, Matteo, Ceccarelli, Giancarlo, Oliva, Alessandra, Maggio, Enrico, Cancelli, Francesca, D'Ardes, Damiano, Amitrano, Maria, Zicari, Anna Maria, Cinicola, Bianca Laura, Taliani, Gloria, Cangemi, Roberto, Lichtner, Miriam, Falcone, Marco, Orlando, Federica, Pugliese, Francesco, Venditti, Mario, Mastroianni, Claudio Maria, and Violi, Francesco

Abstract

PaO2/FiO2 (P/F ratio) is considered a marker of hypoxia/hypoxemia and mortality. Several prothrombotic changes are associated with the decrease of P/F ratio. The role of P/F ratio in patients with arterial and venous thrombosis remains unclear. The aim of this study was to assess in patients with coronavirus disease 2019 (COVID-19), the association between P/F ratio and arterial/venous thrombosis. One thousand and four hundred and six COVID-19 patients were recruited; 289 (21%) patients had P/F ratio < 200 and 1117 (79%) ≥ 200. Compared to the patients with P/F ratio ≥ 200, those with P/F ratio < 200 were older and with higher levels of glycemia, D–dimer and lower levels of albumin. Multiple linear regression analysis showed that albumin (standardized coefficient β: 0.156; SE: 0.001; p = 0.0001) and D–dimer (standardized coefficient β: -0.135; SE: 0.0001; p = 0.0001) were associated with P/F ratio. During the hospitalization 159 patients were transferred in intensive care unit (ICU), 253 patients died, 156 patients had arterial or venous thrombotic events. A bivariate logistic analysis was performed to analyze the predictors of thrombosis in COVID-19 patients; P/F ratio < 200 (Odds Ratio: [OR] 1.718, 95% Confidence Interval [CI] 1.085–2.718, p = 0.021), albumin (OR 1.693, 95% CI 1.055–2.716, p = 0.029), D-dimer (OR 3.469, 95% CI 2.110–5.703, p < 0.0001), coronary artery disease (CAD) (OR 1.800, 95% CI 1.086–2.984, p = 0.023) and heart failure (OR 2.410 95% CI 1.385–4.193, p = 0.002) independently predicted thrombotic events in this population. This study suggests that the P/F ratio is associated with thrombotic events by promoting a hypercoagulation state in patients hospitalized for COVID-19. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Correction to: Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study

Author

Raparelli, Valeria, Pastori, Daniele, Pignataro, Serena Francesca, Vestri, Anna Rita, Pignatelli, Pasquale, Cangemi, Roberto, Proietti, Marco, Davì, Giovanni, Hiatt, William Robert, Lip, Gregory Yoke Hong, Corazza, Gino Roberto, Perticone, Francesco, Violi, Francesco, Basili, Stefania, and ARAPACIS Study Collaborators

Published
2018
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48. Serological response and relationship with gender-sensitive variables among healthcare workers after SARS-CoV-2 vaccination

Author

Cangemi, Roberto, Di Franco, Manuela, Angeloni, Antonio, Zicari, Alessandra, Cardinale, Vincenzo, Visentini, Marcella, Antonelli, Guido, Napoli, Anna, Anastasi, Emanuela, Romiti, Giulio Francesco, D'Alba, Fabrizio, Alvaro, Domenico, Polimeni, Antonella, Basili, Stefania, and Sapienzavax Collaborators, Null

Subjects
mRNA vaccine, COVID-19, BNT162b2, SARS-CoV-2, antibody response, Medicine (miscellaneous)
Abstract

Vaccine-induced immunity is a key strategy in the long-term control of the COVID-19 pandemic. The aim of our study was to explore the relationship between mRNA vaccine-induced antibodies and gender-sensitive variables among healthcare workers. Two thousand-sixty-five volunteers who received the BNT162b2 vaccine were enrolled in the study and followed up. Demographic, clinical, and social variables (educational level, marital status, occupation, childcare) were evaluated through a self-administered questionnaire. Anti-Spike (S) IgG were measured at 1 month (T1) and at 5 months (T2) after the second vaccine dose. At T1, median anti-S IgG values were 693 [394–>800] AU/mL (1 AU = 2.6 BAU). Values > 800 AU/mL (2080 BAU/mL) were directly associated with a previous COVID-19 (p < 0.001) infection and inversely with age (p < 0.001), smoking habit (p < 0.001), and autoimmune diseases (p < 0.001). At T2, a significant decreasing in anti-S IgG values was observed (187 [81–262] AU/mL), with a median decrease of 72 [60–82]%. On multivariate data analysis, a reduction of more than 82% was directly associated with male sex (p < 0.021), age (p < 0.001), smoking (p = 0.038), hypertension (p = 0.042), and, inversely, with previous COVID-19 infection (p < 0.001) and being “cohabiting” (p = 0.005). Our findings suggest that demographic, clinical, and social variables play a role in anti-S IgG values decreasing in long-term follow up and should be considered to find personalized vaccine schedules.

Published
2022

49. THE ADA (AGE-D-DIMER-ALBUMIN) SCORE TO PREDICT THROMBOSIS IN SARS-CoV-2

Author

Violi, Francesco, Pignatelli, Pasquale, Vestri, Anna Rita, Spagnoli, Alessandra, Cipollone, Francesco, Ceccarelli, Giancarlo, Oliva, Alessandra, Amitrano, Maria, Pirro, Matteo, Taliani, Gloria, Cangemi, Roberto, Lichtner, Miriam, Pugliese, Francesco, Falcone, Marco, D'Ardes, Damiano, Venditti, Mario, Mastroianni, Claudio Maria, Loffredo, Lorenzo, D'Agostino, Fausto, Agrò, Felice Eugenio, Mattei, Alessia, Tibullo, Loredana, Nunziata, Maria Grazia, Iorio, Valeria, Iuliano, Natalia, Mangiacapra, Sara, Raimondo, Mariangela, Atteno, Mariangela, Ferri, Claudio, Grassi, Davide, Desideri, Giovambattista, Abballe, Stefano, Dell'Isola, Serena, Rocco, Monica, Alampi, Daniela, Del Borgo, Cosmo, Bianconi, Vanessa, Mannarino, Massimo Raffaele, Figorilli, Filippo, Maggio, Enrico, and Fino, Pasquale.

Subjects
Fibrin Fibrinogen Degradation Products, SARS-CoV-2, COVID-19, Humans, Hematology, venous thrombosis, viral infection, thrombosis, Serum Albumin
Abstract

Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related pneumonia is associated with venous and arterial thrombosis. Aim of the study was to find out a new score for predicting thrombosis in patients with SARS-CoV-2. Methods We included a cohort of 674 patients affected by SARS-CoV-2, not requiring intensive care units, and followed-up during the hospitalization until discharge. Routine analyses performed at in-hospital admission included also serum albumin and D-dimer while arterial and venous thromboses were the endpoints of the study. Results During the follow-up, 110 thrombotic events were registered; patients with thrombotic events were older and had lower albumin and higher D-dimer, compared with thrombotic event-free ones. On multivariable logistic regression with step-by-step procedure age, serum albumin, and D-dimer were independently associated with thrombotic events. The linear combination of age, D-dimer, and albumin allowed to build-up the ADA (age-D-dimer-albumin) score, whose area under the curve (AUC) was 0.752 (95% confidence interval [CI], 0.708–0.795). ADA score was internally validated by bootstrap sampling procedure giving an AUC of 0.752 (95% CI: 0.708–0.794). Conclusion Combination of age, D-dimer, and albumin in the ADA score allows identifying SARS-CoV-2 patients at higher risk of thrombotic events.

Published
2022

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