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2 results on '"Canine gastric polyps"'

1. An immunohistochemical study of canine spontaneous gastric polyps.

Author

Amorim, Irina, Taulescu, Marian, Ferreira, Andreia, Rêma, Alexandra, Reis, Celso, Faustino, Augusto, Cătoi, Cornel, and Gärtner, Fátima

Subjects
*NEOPLASTIC cell transformation, *PHYSICAL sciences, *MUCOUS membranes, *MOLECULAR physics, *GRAM-negative bacteria
Abstract

Background Gastric polyps (GP) are characterised by luminal overgrowths projecting above the plane of the mucosal surface that can be classified as non-neoplastic and neoplastic lesions. In humans, recent studies have drawn attention the malignant potential of some of these lesions. However, gastric polyps are uncommon lesions in dogs. Findings In this study, the presence of Helicobacter spp., the cellular proliferative activity, potential phenotypic alterations, COX-2 and p53 expression in canine spontaneous gastric polyps were investigated. The expression of these molecules was also studied in normal canine gastric mucosa in order to gain further knowledge of the significance of their loss or overexpression in gastric lesions. Conclusions The normal expression of almost all the factors evaluated, along with the reduced proliferative activity is strongly suggestive that, in dogs, spontaneous gastric polyps are not only a rare finding but also of benign nature. [ABSTRACT FROM AUTHOR]

Published
2014
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2. An immunohistochemical study of canine spontaneous gastric polyps

Author

Cornel Catoi, Augusto Faustino, Alexandra Rêma, Celso A. Reis, Marian Taulescu, Fátima Gärtner, Andreia Ferreira, and Irina Amorim

Subjects
Male, p53, Pathology, medicine.medical_specialty, Histology, 040301 veterinary sciences, Helicobacter spp, Stomach Diseases, Short Report, Canine gastric polyps, Biology, Gastroenterology, Pathology and Forensic Medicine, 0403 veterinary science, 03 medical and health sciences, 0302 clinical medicine, Dogs, Polyps, Internal medicine, otorhinolaryngologic diseases, medicine, Prevalence, Animals, Dog Diseases, CDX2, Cell Proliferation, Helicobacter pylori, 04 agricultural and veterinary sciences, General Medicine, COX-2, Immunohistochemistry, digestive system diseases, 3. Good health, Gastric Polyp, Cyclooxygenase 2, Gastric Mucosa, 030220 oncology & carcinogenesis, Female, Tumor Suppressor Protein p53, Ki67
Abstract

Background Gastric polyps (GP) are characterised by luminal overgrowths projecting above the plane of the mucosal surface that can be classified as non-neoplastic and neoplastic lesions. In humans, recent studies have drawn attention to the malignant potential of some of these lesions. However, gastric polyps are uncommon lesions in dogs. Findings In this study, the presence of Helicobacter spp., the cellular proliferative activity, potential phenotypic alterations, COX-2 and p53 expression in canine spontaneous gastric polyps were investigated. The expression of these molecules was also studied in normal canine gastric mucosa in order to gain further knowledge of the significance of their loss or overexpression in gastric lesions. Conclusions The normal expression of almost all the factors evaluated, along with the reduced proliferative activity is strongly suggestive that, in dogs, spontaneous gastric polyps are not only a rare finding but also of benign nature. Virtual Slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_166

Published
2014

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