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3. Case Report: A Case Report of Stereotactic Ventricular Arrhythmia Radioablation (STAR) on Large Cardiac Target Volume by Highly Personalized Inter- and Intra-fractional Image Guidance

Author

Narducci, Maria Lucia, primary, Cellini, Francesco, additional, Placidi, Lorenzo, additional, Boldrini, Luca, additional, Perna, Francesco, additional, Bencardino, Gianluigi, additional, Pinnacchio, Gaetano, additional, Bertolini, Roberta, additional, Cannelli, Giorgio, additional, Frascino, Vincenzo, additional, Tagliaferri, Luca, additional, Chiesa, Silvia, additional, Mattiucci, Gian Carlo, additional, Balducci, Mario, additional, Gambacorta, Maria Antonietta, additional, Rossi, Marco, additional, Indovina, Luca, additional, Pelargonio, Gemma, additional, Valentini, Vincenzo, additional, and Crea, Filippo, additional

Published
2020
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4. Case Report: A Case Report of Stereotactic Ventricular Arrhythmia Radioablation (STAR) on Large Cardiac Target Volume by Highly Personalized Inter- and Intra-fractional Image Guidance

Author

Narducci, Maria Lucia, Cellini, Francesco, Placidi, Lorenzo, Boldrini, Luca, Perna, F., Bencardino, Gianluigi, Pinnacchio, Gaetano, Bertolini, Roberta, Cannelli, Giorgio, Frascino, Vincenzo, Tagliaferri, Luca, Chiesa, Silvia, Mattiucci, Gian Carlo, Balducci, Mario, Gambacorta, Maria Antonietta, Rossi, M., Indovina, Luca, Pelargonio, Gemma, Valentini, Vincenzo, Crea, Filippo, Narducci M. L., Cellini F. (ORCID:0000-0002-2145-2300), Placidi L., Boldrini L., Bencardino G., Pinnacchio G., Bertolini R., Cannelli G. (ORCID:0000-0002-8897-3039), Frascino V., Tagliaferri L. (ORCID:0000-0003-2308-0982), Chiesa S. (ORCID:0000-0003-0168-3459), Mattiucci G. C. (ORCID:0000-0001-6500-0413), Balducci M. (ORCID:0000-0003-0398-9726), Gambacorta M. A. (ORCID:0000-0001-5455-8737), Indovina L., Pelargonio G., Valentini V. (ORCID:0000-0003-4637-6487), Crea F. (ORCID:0000-0001-9404-8846), Narducci, Maria Lucia, Cellini, Francesco, Placidi, Lorenzo, Boldrini, Luca, Perna, F., Bencardino, Gianluigi, Pinnacchio, Gaetano, Bertolini, Roberta, Cannelli, Giorgio, Frascino, Vincenzo, Tagliaferri, Luca, Chiesa, Silvia, Mattiucci, Gian Carlo, Balducci, Mario, Gambacorta, Maria Antonietta, Rossi, M., Indovina, Luca, Pelargonio, Gemma, Valentini, Vincenzo, Crea, Filippo, Narducci M. L., Cellini F. (ORCID:0000-0002-2145-2300), Placidi L., Boldrini L., Bencardino G., Pinnacchio G., Bertolini R., Cannelli G. (ORCID:0000-0002-8897-3039), Frascino V., Tagliaferri L. (ORCID:0000-0003-2308-0982), Chiesa S. (ORCID:0000-0003-0168-3459), Mattiucci G. C. (ORCID:0000-0001-6500-0413), Balducci M. (ORCID:0000-0003-0398-9726), Gambacorta M. A. (ORCID:0000-0001-5455-8737), Indovina L., Pelargonio G., Valentini V. (ORCID:0000-0003-4637-6487), and Crea F. (ORCID:0000-0001-9404-8846)

Abstract

Introduction: Although catheter ablation is the current gold standard treatment for refractory ventricular arrhythmias, sometimes its efficacy is not optimal and it's associated with high risks of procedural complication and death. Stereotactic arrhythmia radioablation (STAR) is increasingly being adopted for such clinical presentation, considering its efficacy and safety. Case Presentation: We do report our experience managing a case of high volume of left ventricle for refractory ventricular tachycardia in advanced heart failure patient, by delivering a single fraction of STAR through an highly personalization of dose delivery applying repeated inter- and continuous intra-fraction image guidance. Conclusion: According to the literature reports, we recommend considering increasing as much as possible the personalization features and safety technical procedure as long as that is not significantly affecting the STAR duration. Moreover, the duration in itself shouldn't be the main parameter, but balanced into the frame of possibly obtainable outcome improvement. At best of our knowledge, this is the first report applying such specific technology onto this clinical setting. Future studies will clarify these issues.

Published
2020

5. IMproved MAnagement (IM-MA study) in cancer-related pain: the value of a joint approach by an integrated team of radiotherapist and anesthetist

Author

Manfrida, Stefania, Masiello, V, Cellini, Francesco, Adducci, Enrica, Polidori, Lorenzo, Longo, Silvia, Cannelli, Giorgio, Balducci, Mario, Rossi, Marco, Valentini, Vincenzo, Manfrida, S, Cellini, F (ORCID:0000-0002-2145-2300), Adducci, E (ORCID:0000-0002-8977-762X), Polidori, L, Longo, S, Cannelli, G (ORCID:0000-0002-8897-3039), Balducci, M (ORCID:0000-0003-0398-9726), Rossi, M (ORCID:0000-0002-4539-5670), Valentini, V (ORCID:0000-0003-4637-6487), Manfrida, Stefania, Masiello, V, Cellini, Francesco, Adducci, Enrica, Polidori, Lorenzo, Longo, Silvia, Cannelli, Giorgio, Balducci, Mario, Rossi, Marco, Valentini, Vincenzo, Manfrida, S, Cellini, F (ORCID:0000-0002-2145-2300), Adducci, E (ORCID:0000-0002-8977-762X), Polidori, L, Longo, S, Cannelli, G (ORCID:0000-0002-8897-3039), Balducci, M (ORCID:0000-0003-0398-9726), Rossi, M (ORCID:0000-0002-4539-5670), and Valentini, V (ORCID:0000-0003-4637-6487)

Abstract

n/a

Published
2019

6. Dietary Conjugated Linoleic Acid-Enriched Cheeses Influence the Levels of Circulating n-3 Highly Unsaturated Fatty Acids in Humans

Author

Murru, Elisabetta, primary, Carta, Gianfranca, additional, Cordeddu, Lina, additional, Melis, Maria, additional, Desogus, Erika, additional, Ansar, Hastimansooreh, additional, Chilliard, Yves, additional, Ferlay, Anne, additional, Stanton, Catherine, additional, Coakley, Mairéad, additional, Ross, R., additional, Piredda, Giovanni, additional, Addis, Margherita, additional, Mele, Maria, additional, Cannelli, Giorgio, additional, Banni, Sebastiano, additional, and Manca, Claudia, additional

Published
2018
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7. Low back pain: comparison between epidural steroid and sympathetic lumbar block with ropivacaine

Author

Mascaro, Adriana, Gualtieri, Elisabetta, Zappia, Luca, Adducci, Enrica, Cannelli, Giorgio, Rinaldi, Silvia, Gualtieri, Elisabetta (ORCID:0000-0003-2745-9500), Adducci, Enrica (ORCID:0000-0002-8977-762X), Cannelli, Giorgio (ORCID:0000-0002-8897-3039), Mascaro, Adriana, Gualtieri, Elisabetta, Zappia, Luca, Adducci, Enrica, Cannelli, Giorgio, Rinaldi, Silvia, Gualtieri, Elisabetta (ORCID:0000-0003-2745-9500), Adducci, Enrica (ORCID:0000-0002-8977-762X), and Cannelli, Giorgio (ORCID:0000-0002-8897-3039)

Abstract

The purpose of this randomized study was to compare analgesic efficacy of epidural injection of steroid and sympathetic lumbar block with ropivacaina in patients sufferingfrom low back pain.

Published
2009

8. Immune response at birth, long term immune memory and 2 years follow-up after in utero anti-HBV DNA immunization

Author

Fazio, Vito Michele, Ria, Francesco, Franco, E, Rosati, Paolo, Cannelli, Giorgio, Signori, E, Parrella, P, Zaratti, L, Iannace, Erika, Monego, Giovanni, Blogna, S, Fioretti, D, Iurescia, S, Filippetti, R, Rinaldi, Monica Fernanda, Ria, Francesco (ORCID:0000-0002-8444-0307), Rosati, Paolo (ORCID:0000-0003-0270-7328), Cannelli, Giorgio (ORCID:0000-0002-8897-3039), Monego, Giovanni (ORCID:0000-0002-1007-1385), Fazio, Vito Michele, Ria, Francesco, Franco, E, Rosati, Paolo, Cannelli, Giorgio, Signori, E, Parrella, P, Zaratti, L, Iannace, Erika, Monego, Giovanni, Blogna, S, Fioretti, D, Iurescia, S, Filippetti, R, Rinaldi, Monica Fernanda, Ria, Francesco (ORCID:0000-0002-8444-0307), Rosati, Paolo (ORCID:0000-0003-0270-7328), Cannelli, Giorgio (ORCID:0000-0002-8897-3039), and Monego, Giovanni (ORCID:0000-0002-1007-1385)

Abstract

Infections occurring at the end of pregnancy, during birth or by breastfeeding are responsible for the high toll of death among first-week infants. In-utero DNA immunization has demonstrated the effectiveness in inducing specific immunity in newborns. A major contribution to infant immunization would be achieved if a vaccine proved able to be protective as early as at the birth, preventing the typical 'first-week infections'. To establish its potential for use in humans, in-utero DNA vaccination efficiency has to be evaluated for short- and long-term safety, protection at delivery, efficacy of boosts in adults and effective window/s for modulation of immune response during pregnancy, in an animal model suitable with human development. Here we show that a single intramuscular in-utero anti-HBV DNA immunization at two-thirds of pig gestation produces, at birth, antibody titers considered protective in humans. The boost of antibody titers in every animal following recall at 4 and 10 months demonstrates the establishment of immune memory. The safety of in-utero fetus manipulation is guaranteed by short-term (no fetus loss, lack of local alterations, at-term spontaneous delivery, breastfeeding) and long-term (2 years) monitoring. Treatment of fetuses closer to delivery results in immune ignorance without induction of tolerance. This result highlights the repercussion of selecting the appropriate time point when this approach is used to deliver therapeutic genes. All these findings illustrate the relevance of naked DNA-based vaccination technology in therapeutic efforts aimed to prevent the high toll of death among first-week infants.

Published
2004

9. Sympathetic blockade in oncologic pain

Author

Mascaro, Adriana, Adducci, Enrica, Cannelli, Giorgio, Morelli Sbarra, Gloria, Boninsegna, R, Evangelista, Maurizio, Iodice, Francesco, and Camaioni, Domenico

Subjects
DOLORE ONCOLOGICO, BLOCCO DEL SISTEMA NERVOSO SIMPATICO, Settore MED/41 - ANESTESIOLOGIA
Published
1999

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