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450 results on '"Canoui-Poitrine, Florence"'

1. CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy

Author

Gonnin, Cécile, Leemans, Michelle, Canoui-Poitrine, Florence, Lebraud, Morgane, Corneau, Aurélien, Roquebert, Louise, Caillet, Philippe, Gay, Pierre, Canovas, Johanna, Histe, Axelle, Blanc, Catherine, El-Sissy, Carine, Larbi, Anis, Poisson, Johanne, Ober, Pauline, Boudou-Rouquette, Pascaline, Natella, Pierre-André, Vallet, Hélène, Saadaoui, Besma, Layese, Richard, Tartour, Eric, Paillaud, Elena, and Granier, Clémence

Published
2024
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3. Efficacy and safety of dapsone in adult primary immune thrombocytopenia

Author

Larue, Marion, Moulis, Guillaume, Rueter, Manuela, Audia, Sylvain, Terriou, Louis, Viallard, Jean François, Pan Petesch, Brigitte, Royer, Bruno, Bonnotte, Bernard, Galicier, Lionel, Lambotte, Olivier, Lefrere, François, Cheze, Stéphane, Ebbo, Mikael, Duong, Tu Ahn, Boutin, Emmanuelle, Languille, Laetitia, Mahevas, Matthieu, Godeau, Bertrand, Canoui-Poitrine, Florence, and Michel, Marc

Published
2025
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7. Predictors of three-month mortality and severe chemotherapy-related adverse events in patients aged 70 years and older with metastatic non-small-cell lung cancer: A secondary analysis of ESOGIA-GFPC-GECP 08–02 study

Author

Gendarme, Sébastien, Zebachi, Sonia, Corre, Romain, Greillier, Laurent, Justeau, Grégoire, Bylicki, Olivier, Decroisette, Chantal, Auliac, Jean-Bernard, Guisier, Florian, Geier, Margaux, Ricordel, Charles, Frelaut, Maxime, Paillaud, Elena, Chouaïd, Christos, and Canouï-Poitrine, Florence

Published
2024
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13. Changes in amyloidosis phenotype over 11 years in a cardiac amyloidosis referral centre cohort in France

Author

Damy, Thibaud, Zaroui, Amira, de Tournemire, Marie, Kharoubi, Mounira, Gounot, Romain, Galat, Arnault, Guendouz, Soulef, Funalot, Benoit, Itti, Emmanuel, Roulin, Louise, Audard, Vincent, Fanen, Pascale, Leroy, Vincent, Poulot, Elsa, Belhadj, Karim, Mallet, Sophie, Deep Singh Chadah, Gagan, Planté-Bordeneuve, Violaine, Gendre, Thierry, Chevalier, Xavier, Guignard, Sandra, Bequignon, Emilie, Bartier, Sophie, Folliguet, Thierry, Lemonier, François, Audureau, Etienne, Tixier, Denis, Canoui-Poitrine, Florence, Lefaucheur, Jean-Pascal, Souvannanorath, Sarah, Authier, Francois-Jerome, Maupou, Steven, Hittinger, Luc, Molinier-Frenkel, Valérie, David, Jean-Philippe, Broussier, Amaury, Oghina, Silvia, and Teiger, Emmanuel

Published
2023
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14. Should we screen for colorectal cancer in people aged 75 and over? A systematic review - collaborative work of the French geriatric oncology society (SOFOG) and the French federation of digestive oncology (FFCD)

Author

Guittet, Lydia, Quipourt, Valérie, Aparicio, Thomas, Carola, Elisabeth, Seitz , Jean-François, Paillaud, Elena, Lievre, Astrid, Boulahssass, Rabia, Vitellius, Carole, Bengrine, Leila, Canoui-Poitrine, Florence, and Manfredi, Sylvain

Published
2023
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16. Prolonged response after TPO-RA discontinuation in primary ITP: results of a prospective multicenter study

Author

Guillet, Stéphanie, Crickx, Etienne, Azzaoui, Imane, Chappert, Pascal, Boutin, Emmanuelle, Viallard, Jean-François, Rivière, Etienne, Gobert, Delphine, Galicier, Lionel, Malphettes, Marion, Cheze, Stéphane, Lefrere, François, Audia, Sylvain, Bonnotte, Bernard, Lambotte, Olivier, Noel, Nicolas, Fain, Olivier, Moulis, Guillaume, Hamidou, Mohamed, Gerfaud-Valentin, Mathieu, Marolleau, Jean-Pierre, Terriou, Louis, Martis, Nihal, Morin, Anne-Sophie, Perlat, Antoinette, Le Gallou, Thomas, Roy-Peaud, Frédérique, Robbins, Ailsa, Lega, Jean-Christophe, Puyade, Matthieu, Comont, Thibault, Limal, Nicolas, Languille, Laetitia, Zarrour, Anissa, Luka, Marine, Menager, Mickael, Belmondo, Thibault, Hue, Sophie, Canoui-Poitrine, Florence, Michel, Marc, Godeau, Bertrand, and Mahévas, Matthieu

Published
2023
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19. Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study

Author

Guillet, Stéphanie, Loustau, Valentine, Boutin, Emmanuelle, Zarour, Anissa, Comont, Thibault, Souchaud-Debouverie, Odile, Costedoat Chalumeau, Nathalie, Pan-Petesch, Brigitte, Gobert, Delphine, Cheze, Stéphane, Viallard, Jean Francois, Morin, Anne-Sophie, Sauvetre, Gaetan, Cliquennois, Manuel, Royer, Bruno, Masseau, Agathe, Terriou, Louis, Fieschi, Claire, Lambotte, Olivier, Girault, Stéphane, Lioger, Bertrand, Audia, Sylvain, Sacre, Karim, Lega, Jean Christophe, Langlois, Vincent, Benachi, Alexandra, Orvain, Corentin, Devidas, Alain, Humbert, Sebastien, Gambier, Nicolas, Ruivard, Marc, Zarrouk, Virginie, Ebbo, Mikael, Willems, Lise, Segaux, Lauriane, Mahevas, Matthieu, Haddad, Bassam, Michel, Marc, Canoui-Poitrine, Florence, and Godeau, Bertrand

Published
2023
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20. High-Dose Steroids for Nonresolving Acute Respiratory Distress Syndrome in Critically Ill COVID-19 Patients Treated With Dexamethasone: A Multicenter Cohort Study

Author

Lopinto, Julien, Arrestier, Romain, Peiffer, Bastien, Gaillet, Antoine, Voiriot, Guillaume, Urbina, Tomas, Luyt, Charles-Edouard, Bellaïche, Raphaël, Pham, Tái, Ait-Hamou, Zakaria, Roux, Damien, Clere-Jehl, Raphaël, Azoulay, Elie, Gaudry, Stéphane, Mayaux, Julien, Mekontso Dessap, Armand, Canoui-Poitrine, Florence, and de Prost, Nicolas

Published
2023
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22. Analysis of mRNA vaccination-elicited RBD-specific memory B cells reveals strong but incomplete immune escape of the SARS-CoV-2 Omicron variant

Author

Sokal, Aurélien, Broketa, Matteo, Barba-Spaeth, Giovanna, Meola, Annalisa, Fernández, Ignacio, Fourati, Slim, Azzaoui, Imane, de La Selle, Andrea, Vandenberghe, Alexis, Roeser, Anais, Bouvier-Alias, Magali, Crickx, Etienne, Languille, Laetitia, Michel, Marc, Godeau, Bertrand, Gallien, Sébastien, Melica, Giovanna, Nguyen, Yann, Zarrouk, Virginie, Canoui-Poitrine, Florence, Noizat-Pirenne, France, Megret, Jérôme, Pawlotsky, Jean-Michel, Fillatreau, Simon, Simon-Lorière, Etienne, Weill, Jean-Claude, Reynaud, Claude-Agnès, Rey, Félix A., Bruhns, Pierre, Chappert, Pascal, and Mahévas, Matthieu

Published
2022
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24. Energy expenditure profiles and the risk of early limiting toxicity in older patients with cancer: The ELCAPA-25 prospective cohort survey

Author

Baudin, Aurélie, Bobin, Margot, Canovas, Johanna, Chaoui, Sabrina, Iratni, Lina, Garrigou, Sonia, Lacour, Sandrine, Mabungu, Helène, Morisset, Laure, Saadaoui, Besma, Boudou-Rouquette, Pascaline, de Moura, Alexandre, Martinez-Tapia, Claudia, Serrano, Adolfo Gonzalez, Chahwakilian, Anne, Jouinot, Anne, Ulmann, Guillaume, Orvoën, Galdric, Chambraud, Clélia, Durand, Jean-Philippe, Caillet, Philippe, Goldwasser, Francois, Paillaud, Elena, and Canouï-Poitrine, Florence

Published
2022
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26. mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants

Author

Sokal, Aurélien, Barba-Spaeth, Giovanna, Fernández, Ignacio, Broketa, Matteo, Azzaoui, Imane, de La Selle, Andréa, Vandenberghe, Alexis, Fourati, Slim, Roeser, Anais, Meola, Annalisa, Bouvier-Alias, Magali, Crickx, Etienne, Languille, Laetitia, Michel, Marc, Godeau, Bertrand, Gallien, Sébastien, Melica, Giovanna, Nguyen, Yann, Zarrouk, Virginie, Canoui-Poitrine, Florence, Pirenne, France, Mégret, Jérôme, Pawlotsky, Jean-Michel, Fillatreau, Simon, Bruhns, Pierre, Rey, Felix A., Weill, Jean-Claude, Reynaud, Claude-Agnès, Chappert, Pascal, and Mahévas, Matthieu

Published
2021
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27. Auto-antibodies against type I IFNs in > 10% of critically ill COVID-19 patients: a prospective multicentre study

Author

Arrestier, Romain, Bastard, Paul, Belmondo, Thibaut, Voiriot, Guillaume, Urbina, Tomas, Luyt, Charles-Edouard, Gervais, Adrian, Bizien, Lucy, Segaux, Lauriane, Ben Ahmed, Mariem, Bellaïche, Raphaël, Pham, Taï, Ait-Hamou, Zakaria, Roux, Damien, Clere-Jehl, Raphael, Azoulay, Elie, Gaudry, Stéphane, Mayaux, Julien, Fage, Nicolas, Ait-Oufella, Hafid, Moncomble, Elsa, Parfait, Mélodie, Dorgham, Karim, Gorochov, Guy, Mekontso-Dessap, Armand, Canoui-Poitrine, Florence, Casanova, Jean-Laurent, Hue, Sophie, and de Prost, Nicolas

Published
2022
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31. CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy.

Author

Gonnin, Cécile, Leemans, Michelle, Canoui-Poitrine, Florence, Lebraud, Morgane, Corneau, Aurélien, Roquebert, Louise, Caillet, Philippe, Gay, Pierre, Canovas, Johanna, Histe, Axelle, Blanc, Catherine, El-Sissy, Carine, Larbi, Anis, Poisson, Johanne, Ober, Pauline, Boudou-Rouquette, Pascaline, Natella, Pierre-André, Vallet, Hélène, Saadaoui, Besma, and Layese, Richard

Subjects
T-cell exhaustion, OLDER people, MEDICAL sciences, T cells, OLDER patients
Abstract

Background: Immune ageing complicates cancer treatment in older individuals. While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age. This study investigates different CD8+ T cell subsets usually associated with senescence, in cancer patients over 70 years old who are undergoing anti-PD-1/PD-L1 immunotherapy, and examines the relationship between these senescent cells and prior chemotherapy exposure. We analyzed data from the Elderly Cancer Patient (ELCAPA) cohort, which included 35 patients enrolled between March 2018 and March 2021. Results: Flow cytometry and unsupervised analysis were employed to characterize Effector Memory CD45RA+ (EMRA) and CD8+ T cell senescence at baseline, before initiating PD-1/PD-L1 therapy. EMRA cells were found to overexpress CD57 and KLRG1 compared to overall CD8+ T cells. Chemotherapy prior to anti-PD-1/PD-L1 was associated with an increased proportion of CD57+ EMRA CD8+ T cells (p = 0.009) and its granzyme B (GRZB) subset (p = 0.007). Using a 10% cut-off to define positivity, the six-month non-response tends to be associated with the CD57+ GRZB+ EMRA positivity (p = 0.097). Other CD8+ T cell subsets (EMRA, CD57+, or KLRG1+), usually associated with senescence, showed no significant association with previous chemotherapy or response to anti-PD-1/anti-PD-L1 therapy. Conclusions: These findings underscore the impact of prior chemotherapy on expanding the pool of senescent T cells, particularly CD57+ EMRA CD8+ T and CD57+ GRZB+ EMRA CD8+ T cells, whose expansion could potentially affect the effectiveness of anti-PD-1/PD-L1 immunotherapy in elderly patients. This highlights the need for tailored approaches in this population. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Phenotype and prognostic factors in geriatric and non‐geriatric patients with transthyretin cardiomyopathy.

Author

Volpentesta, Eugenia, Kharoubi, Mounira, Donadio, Cristiano, Rebiai, Kahina, Fanen, Pascale, Funalot, Benoit, Gendre, Thierry, Audard, Vincent, Canoui‐Poitrine, Florence, Itti, Emmanuel, Teiger, Emmanuel, Planté‐Bordeneuve, Violaine, Oghina, Silvia, Tixier, Denis, Mallet, Sophie, Broussier, Amaury, Damy, Thibaud, and Zaroui, Amira

Subjects
GLOBAL longitudinal strain, ATRIAL fibrillation, CARDIAC amyloidosis, GLOMERULAR filtration rate, ALKALINE phosphatase, DEATH forecasting
Abstract

Aims: Transthyretin cardiac amyloidosis (ATTR‐CM) may be an underestimated cause of heart failure among geriatric patients and represent a unique phenotype and prognostic profile. Methods and results: This retrospective, observational, cohort study characterizes cardiac and extracardiac disorders at diagnosis and assesses prognosis among ATTR‐CM patients based on age (geriatric vs. non‐geriatric) and amyloidosis subtype (wild type, ATTRwt and hereditary, ATTRv). In total, 943 patients with ATTR‐CM were included, of which 306 had ATTRv and 637 had ATTRwt. Among these, 331 (35.1%) were non‐geriatric (<75 years), and 612 (64.9%) were geriatric (≥75 years). The population exhibited conduction abnormalities, atrial fibrillation and ischaemic heart disease that progressively deteriorated with age. Among ATTRwt patients, peripheral neuropathy, neurovegetative symptoms, and hearing loss were present across all age groups, but reports of carpal tunnel symptoms or surgery decreased with age. Conversely, among ATTRv patients, reports of extracardiac symptoms increased with age and Val122ILe mutation was highly prevalent among geriatric patients. The 3‐year survival was higher among non‐geriatric ATTR‐CM patients (76%) than geriatric patients (55%) and predictors of 3‐year mortality differed. Notably, predictors identified among geriatric patients were alkaline phosphatase (ALP) (HR = 1.004, 95% CI: [0.001–1.100)], troponin T hs (HR = 1.005, 95% CI: [1.001–1.120)] and tricuspid insufficiency (HR = 1.194, 95% CI: [1.02–1.230)]. Whereas, among non‐geriatric patients, NT‐proBNP (HR = 1.002, 95% CI: [1.02–1.04], global longitudinal strain (HR = 0.95, 95% CI: [0.922–0.989], and glomerular filtration rate (HR = 0.984, 95% CI: [0.968–1.00) were identified. We propose a 3‐stage prognostic staging system combining troponin T hs (≥44 ng/L) and ALP levels (≥119 UI/L). In the geriatric population, this model discriminated survival more precisely than the National Amyloidosis Centre staging, particularly for classifying between stage 1 (82%), stage 2 (50%) and stage 3 (32%) for ATTRv and ATTRwt. Conclusions: These diagnostic and prognostic indicators, along with ATTR subtype, highlight the distinct characteristics of this important, geriatric ATTR‐CM patient group. Recognizing these mortality markers can be valuable for geriatricians to improve the prognostic quality management of geriatric patients with ATTR‐CM. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Immune thrombocytopenia newly diagnosed during pregnancy: Outcome for mothers and neonates and comparison with chronic immune thrombocytopenia during pregnancy.

Author

Guillet, Stéphanie, Loustau, Valentine, Boutin, Emmanuelle, Souchaud‐Debouverie, Odile, Chalumeau, Nathalie Costedoat, Pascal, Laurent, Gilardin, Laurent, Terriou, Louis, Graveleau, Julie, Comont, Thibault, Henique, Helene, Reynaud, Quitterie, Mahévas, Matthieu, Michel, Marc, Canoui‐Poitrine, Florence, and Godeau, Bertrand

Published
2024
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35. Beyond lung cancer screening, an opportunity for early detection of chronic obstructive pulmonary disease and cardiovascular diseases.

Author

Gendarme, Sébastien, Maitre, Bernard, Hanash, Sam, Pairon, Jean-Claude, Canoui-Poitrine, Florence, and Chouaïd, Christos

Subjects
CORONARY artery calcification, CHRONIC obstructive pulmonary disease, OBSTRUCTIVE lung diseases, HYPERTENSION risk factors, DISEASE risk factors
Abstract

Background Lung cancer screening programs concern smokers at risk for cardiovascular diseases (CVDs) and chronic obstructive pulmonary disease (COPD). The LUMASCAN (LUng Cancer Screening, MArkers and low-dose computed tomography SCANner) study aimed to evaluate the acceptability and feasibility of screening for these 3 diseases in a community population with centralized organization and to determine low-dose computed tomography (CT) markers associated with each disease. Methods This cohort enrolled participants meeting National Comprehensive Cancer Network criteria (v1.2014) in an organized lung cancer–screening program including low-dose CT scans; spirometry; evaluations of coronary artery calcifications (CACs); and a smoking cessation plan at inclusion, 1, and 2 years; then telephone follow-up. Outcomes were the participation rate and the proportion of participants affected by lung cancer, obstructive lung disease, or CVD events. Logistic-regression models were used to identify radiological factors associated with each disease. Results Between 2016 and 2019, a total of 302 participants were enrolled: 61% men; median age 58.8 years; 77% active smoker; 11% diabetes; 38% hypertension; and 27% taking lipid-lowering agents. Inclusion, 1-year, and 2-year participation rates were 99%, 81%, 79%, respectively. After a median follow-up of 5.81 years, screenings detected 12 (4%) lung cancer, 9 of 12 via low-dose CT (78% localized) and 3 of 12 during follow-up (all stage IV), 83 (27%) unknown obstructive lung disease, and 131 (43.4%) moderate to severe CACs warranting a cardiology consultation. Preexisting COPD and moderate to severe CACs were associated with major CVD events with odds ratios of 1.98 (95% confident interval [CI] = 1.00 to 3.88) and 3.27 (95% CI = 1.72 to 6.43), respectively. Conclusion The LUMASCAN study demonstrated the feasibility of combined screening for lung cancer, COPD, and CVD in a community population. Its centralized organization enabled high participation and coordination of healthcare practitioners. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter Coranosmia cohort study

Author

Salmon Ceron, Dominique, Bartier, Sophie, Hautefort, Charlotte, Nguyen, Yann, Nevoux, Jérôme, Hamel, Anne-Laure, Camhi, Yohan, Canouï-Poitrine, Florence, Verillaud, Benjamin, Slama, Dorsaf, Haim-Boukobza, Stephanie, Sourdeau, Elise, Cantin, Delphine, Corré, Alain, Bryn, Agnes, Etienne, Nicolas, Rozenberg, Flore, Layese, Richard, Papon, Jean-François, and Bequignon, Emilie

Published
2020
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41. Long-term Quality of Life in Adult Patients Surviving Purpura Fulminans : An Exposed-Unexposed Multicenter Cohort Study

Author

Hopeful Study Group, Contou, Damien, Canoui-Poitrine, Florence, Coudroy, Rémi, Préau, Sébastien, Cour, Martin, Barbier, François, Terzi, Nicolas, Schnell, Guillaume, Galbois, Arnaud, Zafrani, Lara, Zuber, Benjamin, Ehrmann, Stephan, Gelisse, Elodie, Colling, Delphine, Schmidt, Matthieu, Jaber, Samir, Conia, Alexandre, Sonneville, Romain, Colin, Gwenhaël, Guérin, Laurent, Roux, Damien, Jochmans, Sébastien, Kentish-Barnes, Nancy, Audureau, Etienne, Layese, Richard, Alves, Aline, Ouedraogo, Rachida, Brun-Buisson, Christian, Dessap, Armand Mekontso, and de Prost, Nicolas

Published
2019

42. Epidemiology of Colorectal Cancer: Incidence, Survival, and Risk Factors

Author

Canouï-Poitrine, Florence, Martinez-Tapia, Claudia, Guittet, Lydia, Bouvier, Anne-Marie, Coccolini, Federico, Series Editor, Coimbra, Raul, Series Editor, Kirkpatrick, Andrew W., Series Editor, Di Saverio, Salomone, Series Editor, Ansaloni, Luca, Editorial Board Member, Balogh, Zsolt, Editorial Board Member, Biffl, Walt, Editorial Board Member, Catena, Fausto, Editorial Board Member, Davis, Kimberly, Editorial Board Member, Ferrada, Paula, Editorial Board Member, Fraga, Gustavo, Editorial Board Member, Ivatury, Rao, Editorial Board Member, Kluger, Yoram, Editorial Board Member, Leppaniemi, Ari, Editorial Board Member, Maier, Ron, Editorial Board Member, E. Moore, Ernest, Editorial Board Member, Napolitano, Lena, Editorial Board Member, Peitzman, Andrew, Editorial Board Member, Rielly, Patrick, Editorial Board Member, Rizoli, Sandro, Editorial Board Member, Sakakushev, Boris, Editorial Board Member, Sartelli, Massimo, Editorial Board Member, Scalea, Thomas, Editorial Board Member, Spain, David, Editorial Board Member, Stahel, Philip, Editorial Board Member, Sugrue, Michael, Editorial Board Member, Velmahos, George, Editorial Board Member, Weber, Dieter, Editorial Board Member, de'Angelis, Nicola, editor, and Brunetti, Francesco, editor

Published
2019
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45. Impact of 3-week citrulline supplementation on postprandial protein metabolism in malnourished older patients: The Ciproage randomized controlled trial

Author

Bouillanne, Olivier, Melchior, Jean-Claude, Faure, Cécile, Paul, Muriel, Canouï-Poitrine, Florence, Boirie, Yves, Chevenne, Didier, Forasassi, Christine, Guery, Ester, Herbaud, Stéphane, Le Corvoisier, Philippe, Neveux, Nathalie, Nivet-Antoine, Valérie, Astier, Alain, Raynaud-Simon, Agathe, Walrand, Stéphane, Cynober, Luc, and Aussel, Christian

Published
2019
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48. HIV infection and COVID-19: risk factors for severe disease

Author

Etienne, Nicolas, Karmochkine, Marina, Slama, Laurence, Pavie, Juliette, Batisse, Dominique, Usubillaga, Rafael, Letembet, Valerie-Anne, Brazille, Patricia, Canouï, Etienne, Slama, Dorsaf, Joumaa, Hassan, Canoui-Poitrine, Florence, Segaux, Lauriane, Weiss, Laurence, Viard, Jean-Paul, and Salmon, Dominique

Published
2020
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49. Prognostic value of the G8 and modified-G8 screening tools for multidimensional health problems in older patients with cancer

Author

Caillet, P., Laurent, M., Paillaud, E., Tournigand, C., Lagrange, J.-L., Canouï-Poitrine, F., Bastuji-Garin, S., Audureau, E., Natella, P.A., Segaux, L., Reinald, N., Allain, M., Ibrahim, R., Raccah, S., Martinez-Tapia, Claudia, Paillaud, Elena, Liuu, Evelyne, Tournigand, Christophe, Ibrahim, Rima, Fossey-Diaz, Virginie, Culine, Stéphane, Canoui-Poitrine, Florence, and Audureau, Etienne

Published
2017
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