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18 results on '"Cao, Liangzi"'

2. The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress

Author

Liu, Jingwei, Cao, Liangzi, Wang, Yubang, Zou, Yu, Guo, Qiqiang, Chen, Shu, Jiang, Bo, Wu, Xuan, Zheng, Lixia, Zhang, Siyi, Lu, Songming, Zhou, Keshen, Jiang, Pengcheng, Xiao, Yutong, Yang, Ruohan, Dong, Shiyuan, Li, Ziwei, Chen, Di, Zhang, Ying, Zhang, Naijin, Sun, Guozhe, Xing, Chengzhong, Song, Xiaoyu, Wang, Zhenning, and Cao, Liu

Published
2024
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5. Identifications of genes involved in ABA and MAPK signaling pathways positively regulating cold tolerance in rice

Author

Ding, Guohua, primary, Cao, Liangzi, additional, Iqbal, Zubair, additional, Zhao, Minghui, additional, Cui, Zhibo, additional, Zhou, Jinsong, additional, Lei, Lei, additional, Luo, Yu, additional, Bai, Liangming, additional, Yang, Guang, additional, Wang, Tongtong, additional, Wang, Xueyang, additional, Wang, Rongsheng, additional, Liu, Kai, additional, Li, Zhugang, additional, Qu, Mingnan, additional, and Sun, Shichen, additional

Published
2024
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10. De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity

Author

Liu, Jingwei, primary, Zhou, Tingting, additional, Dong, Xiang, additional, Guo, Qiqiang, additional, Zheng, Lixia, additional, Wang, Xiaoxun, additional, Zhang, Naijin, additional, Li, Danni, additional, Ren, Ling, additional, Yi, Fei, additional, Zhang, Ying, additional, Li, Ziwei, additional, Wang, Xiwen, additional, Deng, Chengsi, additional, Li, Chunlu, additional, Xu, Hongde, additional, Guan, Yi, additional, Li, Xiaoman, additional, Yu, Yang, additional, Guo, Wendong, additional, Wang, Zhuo, additional, Jiang, Bo, additional, Wu, Xuan, additional, Bai, Ning, additional, Feng, Yanling, additional, Ma, Mengtao, additional, Kong, Qingquan, additional, Wei, Jiayi, additional, Wang, Zhenshuang, additional, Li, Hao, additional, Lu, Songming, additional, Cao, Liangzi, additional, Xiao, Yutong, additional, Song, Xiaoyu, additional, Wang, Zhenning, additional, Xing, Chengzhong, additional, and Cao, Liu, additional

Published
2023
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11. OsBBX11 on qSTS4 links to salt tolerance at the seeding stage in Oryza sativa L. ssp. Japonica

Author

Lei, Lei, primary, Cao, Liangzi, additional, Ding, Guohua, additional, Zhou, Jinsong, additional, Luo, Yu, additional, Bai, Liangming, additional, Xia, Tianshu, additional, Chen, Lei, additional, Wang, Jiangxu, additional, Liu, Kai, additional, Lei, Qingjun, additional, Xie, Tingting, additional, Yang, Guang, additional, Wang, Xueyang, additional, Sun, Shichen, additional, and Lai, Yongcai, additional

Published
2023
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12. Expression and regulatory network of E3 ubiquitin ligase NEDD4 family in cancers.

Author

Cao, Liangzi, Li, Hao, Liu, Xiaofang, Wang, Yubang, Zheng, Bowen, Xing, Chengzhong, Zhang, Naijin, and Liu, Jingwei

Subjects
*UBIQUITIN ligases, *AUTOPHAGY, *CELL junctions, *GENE families, *CANCER genes, *PANCREATIC cancer, *THYROID cancer
Abstract

NEDD4 family represent an important group of E3 ligases, which regulate various cellular pathways of cell proliferation, cell junction and inflammation. Emerging evidence suggested that NEDD4 family members participate in the initiation and development of tumor. In this study, we systematically investigated the molecular alterations as well as the clinical relevance regarding NEDD4 family genes in 33 cancer types. Finally, we found that NEDD4 members showed increased expression in pancreas cancer and decreased expression in thyroid cancer. NEDD4 E3 ligase family genes had an average mutation frequency in the range of 0-32.1%, of which HECW1 and HECW2 demonstrated relatively high mutation rate. Breast cancer harbors large amount of NEDD4 copy number amplification. NEDD4 family members interacted proteins were enriched in various pathways including p53, Akt, apoptosis and autophagy, which were confirmed by further western blot and flow cytometric analysis in A549 and H1299 lung cancer cells. In addition, expression of NEDD4 family genes were associated with survival of cancer patients. Our findings provide novel insight into the effect of NEDD4 E3 ligase genes on cancer progression and treatment in the future. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Validation of the QTL for grain length linked to the Rht-B1locus in two genetic backgrounds of bread wheat (Triticum aestivumL.)

Author

Onishi, Kazumitsu, Akie, Taiga, Cao, Liangzi, Mori, Masahiko, Hattori, Maya, Hira, Kazuma, Wano, Atsushi, Oki, Wakana, and Miura, Hideho

Abstract

Grain size is an important agronomic trait that influences the yield and end-use quality of bread wheat (Triticum aestivumL.). We conducted quantitative trait loci (QTL) analysis using recombinant inbred lines derived from a cross of a semi-dwarf modern variety with large grains (Zenkoujikomugi: Zen) and a landrace with small grains (Chinese Spring: CS). Grain size was evaluated as grain length (GL), grain width (GW), grain thickness (GT), and thousand-grain weight (TGW) under two environmental conditions. A major QTL (QGl.obu-4B) associated with GL was detected in both environments near the Rht-B1locus for the semi-dwarf trait on chromosome 4B, despite Zen and CS having the same Rht-B1aallele. No QTL for GW was found in the QGl.obu-4Bregion, and QTLs for GT and TGW was detected in only one environment. To validate the effect of QGl.obu-4B, we developed two backcrossed populations in the CS and Zen genetic backgrounds. The Zen-derived allele conferred larger GL, GW, and GT, resulting in greater TGW (13.7% increase compared to the CS-derived allele) in the CS background.In contrast, the QGl.obu-4Beffect was smaller in the Zen background, and the Zen-derived allele increased TGW by only 7.0%. The QTL was located within the 168-Mbp region tightly linked to the Rht-B1locus. Further characterization and fine-mapping of QGl.obu-4Bwill facilitate the use of this allele by marker-assisted selection in wheat breeding programs.

Published
2021
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