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155 results on '"Cao, Y. Charles"'

2. Functional Selection of Tau Oligomerization‐Inhibiting Aptamers.

Author

Wang, Bang, Pan, Xiaoshu, Teng, I‐Ting, Li, Xiaowei, Kobeissy, Firas, Wu, Zo‐Yu, Zhu, Jiepei, Cai, Guangzheng, Yan, He, Yan, Xin, Liang, Mingwei, Yu, Fahong, Lu, Jianrong, Yang, Zunyi, Biondi, Elisa, Haskins, William, Cao, Y. Charles, Benner, Steven A., Tan, Weihong, and Wang, Kevin K.

Subjects
TAU proteins, APTAMERS, ALZHEIMER'S disease, TAUOPATHIES, ARACHIDONIC acid, MICROTUBULE-associated proteins, NEURODEGENERATION
Abstract

Pathological hyperphosphorylation and aggregation of microtubule‐associated Tau protein contribute to Alzheimer's Disease (AD) and other related tauopathies. Currently, no cure exists for Alzheimer's Disease. Aptamers offer significant potential as next‐generation therapeutics in biotechnology and the treatment of neurological disorders. Traditional aptamer selection methods for Tau protein focus on binding affinity rather than interference with pathological Tau. In this study, we developed a new selection strategy to enrich DNA aptamers that bind to surviving monomeric Tau protein under conditions that would typically promote Tau aggregation. Employing this approach, we identified a set of aptamer candidates. Notably, BW1c demonstrates a high binding affinity (Kd=6.6 nM) to Tau protein and effectively inhibits arachidonic acid (AA)‐induced Tau protein oligomerization and aggregation. Additionally, it inhibits GSK3β‐mediated Tau hyperphosphorylation in cell‐free systems and okadaic acid‐mediated Tau hyperphosphorylation in cellular milieu. Lastly, retro‐orbital injection of BW1c tau aptamer shows the ability to cross the blood brain barrier and gain access to neuronal cell body. Through further refinement and development, these Tau aptamers may pave the way for a first‐in‐class neurotherapeutic to mitigate tauopathy‐associated neurodegenerative disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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3. A New Folding Motif Formed with an Expanded Genetic Alphabet

Author

Benner, Steven, primary, Wang, Bang, additional, Rocca, James, additional, Hoshika, Shuichi, additional, Chen, Cen, additional, Yang, Zunyi, additional, Esmaeeli, Reza, additional, Wang, Jiangguo, additional, Pan, Xiaoshu, additional, Lu, Jianrong, additional, Wang, Kevin, additional, Cao, Y. Charles, additional, and Tan, Weihong, additional

Published
2022
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11. List of Contributors

Author

Alvarez, Mar, primary, Anderson, George P., additional, Bachmann, Jutta, additional, Biran, Israel, additional, Blake, Diane A., additional, Cao, Y. Charles, additional, Cho, Eun Jeong, additional, Delehanty, James B., additional, Ellington, Andrew D., additional, Goldman, Ellen R., additional, Hayhurst, Andrew, additional, Homola, Jiří, additional, Jacobson, James W., additional, Joos, Thomas O., additional, Kang, Huizhi, additional, Kusterbeck, Anne W., additional, Lechuga, Laura M., additional, Lee, Joo-Woon, additional, Lehmann, Kevin K., additional, Ligler, Frances S., additional, Liu, Jinny L., additional, Medintz, Igor L., additional, Moreno, Miguel, additional, Myszka, David, additional, O'Donoghue, Meghan, additional, Piletsky, Sergey A., additional, Rajendran, Manjula, additional, Richter, Mark M., additional, Sapsford, Kim, additional, Stroock, Abraham D., additional, Taitt, Chris Rowe, additional, Tan, Weihong, additional, Tarsa, Peter B., additional, Thompson, Richard B., additional, Turner, Anthony P.F., additional, Vo-Dinh, Tuan, additional, Walt, David R., additional, Wang, Lin, additional, Yee, Sinclair S., additional, Yu, Xin, additional, and Zinoviev, Kirill, additional

Published
2008
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15. Synthesis of water-soluble 2,2'-diphenyl-1-picrylhydrazyl nanoparticles: a new standard for electron paramagnetic resonance spectroscopy

Author

Ou Chen, Jiaqi Zhuang, Guzzetta, Fabrizio, Lynch, Jared, Angerhofer, Alexander, and Cao, Y. Charles

Subjects
Electron paramagnetic resonance spectroscopy -- Usage, Solvation -- Analysis, Chemistry
Abstract

A size-controlled synthesis of water-soluble 2,2'-diphenyl-1-picrylhydrazyl (DPPH) nanoparticles (NPs) is described. The nanoparticles have displayed size-dependent absorption spectra and fast spin exchange-narrowed single-line electron paramagnetic resonance (EPR) spectra, which have made these water-soluble DPPH NPs suitable for use as a new type of EPR standard.

Published
2009

16. Cylindrical superparticles from semiconductor nanorods

Author

Jiaqi Zhuang, Shaller, Andrew D., Lynch, Jared, Huimeng Wu, Ou Chen, Li, Alexander D.Q., and Cao, Y. Charles

Subjects
Anisotropy -- Analysis, Cadmium -- Chemical properties, Cadmium -- Electric properties, Nanotechnology -- Research, Selenium -- Chemical properties, Selenium -- Electric properties, Solvation -- Analysis, Chemistry
Abstract

Anisotropic colloidal superparticles (SPs) are prepared from CdSe/CdS semiconductor nanorods. These anisotropic SPs are cylindrical disks and the major driving forces controlling the SP shape is attributed to interparticle interactions between nanorods and solvophobic interactions between a superparticle and its surrounding solvent.

Published
2009

17. On doping CdS/ZnS core/shell nanocrystals with Mn

Author

Yongan Yang, Ou Chen, Angerhofer, Alexander, and Cao, Y. Charles

Subjects
Cadmium -- Atomic properties, Cadmium -- Electric properties, Manganese -- Chemical properties, Semiconductor doping -- Analysis, Zinc compounds -- Chemical properties, Zinc compounds -- Electric properties, Chemistry
Abstract

A mechanistic study on the doping of CdS/ZnS core/shell semiconductor nanocrystals with Mn based on a three-step synthesis is presented. The results have provided a mechanism in which nanocrystal doping is obtained by the chemical kinetics of three activation-controlled processes, including dopant absorption, replacement and ZnS-shell growth.

Published
2008

18. Supercrystalline colloidal particles from artificial atoms

Author

Jiaqi Zhuang, Huimeng Wu, Yongan Yang, and Cao, Y. Charles

Subjects
Colloids -- Research, Nanoparticles -- Research, Solvents -- Research, Transmission electron microscopes -- Technology application, Technology application, Chemistry
Abstract

The synthesis of various supercrystalline colloidal particles from different artificial atoms is described. These particles are found to be highly stable in polar solvents and hence can be used in several biomedical applications.

Published
2007

20. One-pot synthesis of high-quality zinc-blende CdS nanocrystals

Author

Cao, Y. Charles and Jianhui Wang

Subjects
Nanotechnology -- Research, Chemical synthesis -- Observations, Chemistry
Abstract

A one-pot synthetic method for producing high-quality CdS nanocrystals is described. It is shown that the nanocrystal nucleation and growth stages can be automatically separated in a homogeneous system with the presence of nucleation initiators.

Published
2004

22. Understanding Fe3O4Nanocube Assembly with Reconstruction of a Consistent Superlattice Phase Diagram

Author

Huang, Xin, Zhu, Jinlong, Ge, Binghui, Deng, Kerong, Wu, Xiaotong, Xiao, Tianyuan, Jiang, Tian, Quan, Zewei, Cao, Y. Charles, and Wang, Zhongwu

Abstract

Nanocube (NC) assemblies display complex superlattice behaviors, which require a systematic understanding of their nucleation and growth as well transformation toward construction of a consistent superlattice phase diagram. This work made use of Fe3O4NCs with controlled environments, and assembled NCs into three-dimensional (3D) superlattices of simple cubic (sc), body-centered cubic (bcc), and face-centered cubic (fcc), acute and obtuse rhombohedral (rh) polymorphs, and 2D superlattices of square and hexagon. Controlled experiments and computations of in situ and static small-angle X-ray scattering (SAXS) as well as electron microscopic imaging revealed that the fcc and bcc polymorphs preferred a primary nucleation at the early stage of NC assembly, which started from the high packing planes of fcc(111) and bcc(110), respectively, in both 3D and 2D cases. Upon continuous growth of superlattice grain (or domain), a confinement stress appeared and distorted fcc and bcc into acute and obtuse rh polymorphs, respectively. The variable magnitudes of competitive interactions between configurational and directional entropy determine the primary superlattice polymorph of either fcc or bcc, while emergent enhancement of confinement effect on enlarged grains attributes to late developed superlattice transformations. Differently, the formation of a sc polymorph requires a strong driving force that either emerges simultaneously or is applied externally so that one easy case of the sc formation can be achieved in 2D thin films. Unlike the traditional Bath deformation pathway that involves an intermediate body-centered tetragonal lattice, the observed superlattice transformations in NC assembly underwent a simple rhombohedral distortion, which was driven by a growth-induced in-plane compressive stress. Establishment of a consistent phase diagram of NC-based superlattices and reconstruction of their assembly pathways provide critical insight and a solid base for controlled design and scalable fabrication of nanocube-based functional materials with desired superlattices and collective properties for real-world applications.

Published
2019
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24. Raman dye-labeled nanoparticles probes for proteins

Author

Cao, Y. Charles, Rongchao Jin, Nam, Jwa-Min, Thaxton, C. Shad, and Mirkin, Chad A.

Subjects
Hydroquinone -- Chemical properties, Nanotechnology -- Research, Proteins -- Properties, Chemistry
Abstract

The demonstration of how one could chemically design Raman dye-functionalized nanoparticle probes with specific protein-binding affinities is presented. The use of the probes, coupled with surface-enhanced Raman scattering spectroscopy, to perform multiplexed screening of protein-small molecule interactions and protein-protein interactions in a microarray format is demonstrated.

Published
2003

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