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For about ten years, at the beginning of each new school year, the University Museum of Chieti has offered to the teachers the possibility of using museum facilities and exhibitions to implement science teaching and learning in the public schools of "Primary and Secondary Education". At the base of these meetings of "scientific teaching ludo" there are simple experiments, easily achievable by students with recycled materials. With time, the need arose to set up a teaching tool useful for tracing the guidelines of the individual game-experiments, almost a "procedure manual". For this reason the Museum has decided to produce a volume, with an intentionally operative editorial format, which represents the result of the experience and a long work of museum education experts and competent designers and graphic designers to promote the construction of thought in the user scientific. It is, in short, the first experiment in the teaching of science, directed at teachers, in which the effort of museum graphics has been developed with the aim of facilitating the use of selected final users (students and even their parents) other than those initials (teachers). The professional figures, that was used to design and create the book, started to developed the work from the dynamics at the base of the game, meant as participatory and emotional process of experience. The games outlined in the collection represent some ways to facilitate a "scientific attitude" to answer the natural questions that children have during their play. There are five macro-topics (acoustics, flotation, flight, motion and chemical transformations), each one developed through three playful activities proposed by different approaches. 1) The first activity (of each topic) is proposed with a "preconceived" modality: it is described entirely through indications to make a game or a toy with the assumption of always enhancing observation and causing that amazement needed to formulate some questions. 2) The second activities are described with a "half-conceived" method to support as much as possible the experimentation: in the description, useful variants to "try" stimulating the research for further questions are suggested to the user. In these activities the box "And if..." appears, with the invitation to continue asking questions and trying experiments to find the answer(s) to the question(s) asked. 3) The third activity is of a "customable" type. Unlike the previous one the box "And if..." does not appear being the proposal already a problem solving. This is a cooperative challenge (without winners and defeated) to be carried out in autonomy or to be "led" (in the event that a support is needed), enhancing in this way children's skills and ideas. At the end of each playful activity, the basic scientific principles are indicated. The terminology of the text has been particularly handle: the language used, while remaining strictly scientific, shows a captivating, simple and understandable style. Furthermore, to facilitate the understanding of the logical steps in the experiment, the collaboration of an expert graphic designer was used who combined artistic ability of the drawing with meticulous and detailed research to give shape to complex and abstract concepts. Furthermore the graphic designer translated into illustrations the basic steps of the experiment to avoid unintentional misunderstandings and to make easier the acquisition of contents. [ABSTRACT FROM AUTHOR]

Background: Children with high-risk medulloblastoma are treated with chemotherapeutic protocols which may affect heart function. We aimed to assesscardiovascular events (CVE) in children with medulloblastoma/primitive neuroectodermal tumors (PNET)., Methods: We retrospectively collected data from a case series of 22 children with high-risk medulloblastoma/PNET admitted to the Santobono-Pausilipon Hospital, Naples, Italy from 2008 to 2016. All patients received the Milan HART protocol for high-risk brain malignancies as first line treatment (induction phase), followed by a consolidation phase with Thiotepa and hematopoietic stem cells transplantation, except for 1 patient who received the Milan HART as second line therapy. Four patients also received second line treatment, while 4 patients also received maintenance therapy. Patients underwent cardiac examination, including ECG, echocardiography and serum biomarkers, before antineoplastic treatment initiation and then when clinically needed. Six patients developed CVE (CVE group); 16 patients had no CVE (NO-CVE group)., Findings: In the CVE group, 3 patients presented acute CVE during chemotherapy (2 patients with left ventricular (LV) dysfunction, 1 patient with arterial hypertension), while 3 patients presented chronic CVE after chemotherapy completion (2 patients with LV dysfunction, 1 patient with ectopic atrial tachycardia). After a 51 months median follow-up, 9 patients died: 4 from the CVE group (in 2 cases heart failure-related deaths) and 5 from the NO-CVE group (progression of disease)., Interpretation: A relevant percentage of children treated for medulloblastoma/PNET develops CVE. Heart failure potentially due to chemotherapy may represent a cause of death. Hence, in these patients, strict cardiac surveillance is essential., Funding: No funding was associated with this study., Competing Interests: Dr. Cuomo, Dr. Mercurio, Dr. Pugliese, Dr. Capasso, Dr. Ruotolo, Dr. Antignano, Dr. Passariello have nothing to disclose. Dr. Tocchetti reports other from Amgen, personal fees from Vivalyfe, outside the submitted work; In addition, Dr. Tocchetti has a patent Canadian Patent No. 2,613,477, issued on Dec 3, 2013. Inventors: Nazareno Paolocci, David A Kass, Carlo G Tocchetti. Owner: Johns Hopkins University, entitled: THIOL-SENSITIVE POSITIVE INOTROPES. JHU Ref.: C04755-P04755–05 with royalties paid, and a patent P75NTR ANTAGONISTS AND TREATMENT OF ACUTE AND CHRONIC CARDIAC DISEASE. Inventors: Paolocci; Nazareno; (Baltimore, MD); Feng; Ning; (Baltimore, MD); Tocchetti; Carlo G.; (Baltimore, MD); Takahashi; Cyrus; (Baltimore, MD); Carter; Bruce; (Nashville, TN). 2020. Patent office: United States Patent and Trademark Office Granted Publication. Patent number US10786543, Publication date: Sep 29, 2020 issued., (© 2021 The Author(s).)

Unlabelled: The aim of this study is to identify the criteria which would allow a differentiation between the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) profiles, obtained from patients who present with problems of minimization of attitude (dissembling) who have shown a minimization of their problems; from patients who answered in a spontaneous and genuine fashion., Methods: Six hundred and fifty five MMPI profiles of outpatients of the Clinical Psychology Unit, University Hospital, Sapienza University of Rome. Patients were subdivided into two groups, based on the reason for attending: those who submitted voluntarily to a psychodiagnostic assessment and those who were assessed by request of an outside authority, e.g., in the case of those whose driving license was suspended. It has hypothesized that the latter group would not present with problems which would preclude obtaining the benefits required. The variables analyzed were the clinical scale and the validity scale MMPI-2, index F-K and the Ds scale of Gough. On the basis of the values of the F-K index and Ds scale, the patients were reclassified into three simulation categories: spontaneous registration; defended and doubtful's., Results: All indexes, validity scales and clinical scales of the standard profile were found to have significant differences between the "dissimulation" and "normal" groups. Sensibility and specificity of profile classification was according to both indexes 76%., Conclusions: Current evidence indicates that simulation of pathology is identifiable in MMPI-2 profiles. Our data demonstrate that it is possible to identify case of defensive minimization. These results confirm the hypothesis that simulation is a dimensional characteristic of MMPI which can reach extreme values in both ways: worsening of slight problems or suppression of existing problems.