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8 results on '"Capón, Alicia"'

3. Assessment of the use and quick preparation of saliva for rapid microbiological diagnosis of COVID-19

Author

Fernández-Pittol, Mariana, primary, Hurtado, Juan Carlos, additional, Moreno-García, Estela, additional, Rubio, Elisa, additional, Navarro, Mireia, additional, Valiente, Marta, additional, Peiró, Aida, additional, Capón, Alicia, additional, Seijas, Nuria, additional, Martínez, Miguel J., additional, Casals-Pascual, Climent, additional, and Vila, Jordi, additional

Published
2020
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4. Improvement in detecting cytomegalovirus drug resistance mutations in solid organ transplant recipients with suspected resistance using next generation sequencing

Author

López-Aladid, Rúben, Guiu, Alba, Mosquera, María Mar, López-Medrano, Francisco, Cofan, Frederic, Linares, Laura, Torre-Cisneros, Julián, Vidal, Elisa, Moreno Camacho, Asunción, Aguado, José María, Cordero, Elisa, Martin-Gandul, Cecilia, Carratalà, Jordi, Sabé, Núria, Niubó, Jordi, Cervera, Carlos, Capón, Alicia, Cervilla, Anna, Santos, Marta, Bodro, Marta, Muñoz, Patricia, Fariñas, María Carmen, Antón, Andrés, Aranzamendi Zaldumbide, Maitane, Montejo, Miguel, Pérez-Romero, Pilar, Len, Oscar, Marcos, María Ángeles, Universitat Autònoma de Barcelona, Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, European Commission, Fundació La Marató de TV3, Universidad de Cantabria, Instituto de Salud Carlos III, Agencia de Gestio d'Ajuts Universitaris i de Recerca, Fundación La Marató TV3, [López-Aladid R, Guiu A, Mosquera MM] Department of Clinical Microbiology, Hospital Clinic, Universidad de Barcelona, Barcelona, Spain. Institute for Global Health (ISGlobal), Barcelona, Spain. [López-Medrano F] Unit of Infectious Diseases, Instituto de Investigación Hospital 12 Octubre (i + 12), University Hospital 12 de Octubre, Madrid, Spain. Universidad Complutense, Madrid, Spain. [Cofán F] Department of Nephrology and Renal Transplant, Hospital Clinic, Universidad de Barcelona, Barcelona, Spain. [Linares L] Department of Infectious Diseases, Hospital Clinic, Universidad de Barcelona, Barcelona, Spain. Institut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona, Spain. [Antón A] Servei de Microbiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Len O] Servei de Malalties Infeccioses, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
Male, 0301 basic medicine, Trasplantació d'òrgans, teixits, etc, Genes, Viral, Molecular biology, Gene Identification and Analysis, Trasplantament hepàtic, Cytomegalovirus, Drug resistance, Pathology and Laboratory Medicine, Sequencing techniques, Cytomegaloviruses, Medicine and Health Sciences, DNA sequencing, Respiratory System Procedures, Multidisciplinary, Microbial Mutation, Antiviral therapy, High-Throughput Nucleotide Sequencing, Genomics, Middle Aged, Medical Microbiology, Viral Pathogens, Viruses, regiones corporales::trasplantes [ANATOMÍA], Medicine, Human Cytomegalovirus, Female, Body Regions::Transplants [ANATOMY], ADN - Anàlisi, Pathogens, Anatomy, Transcriptome Analysis, Research Article, Lung Transplantation, Next-Generation Sequencing, fenómenos microbiológicos::farmacorresistencia microbiana::farmacorresistencia viral [FENÓMENOS Y PROCESOS], Herpesviruses, técnicas de investigación::técnicas genéticas::análisis de secuencias::análisis de secuencias de ADN [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Science, 030106 microbiology, Congenital cytomegalovirus infection, Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Microbial::Drug Resistance, Viral [PHENOMENA AND PROCESSES], Surgical and Invasive Medical Procedures, Microbiology, 03 medical and health sciences, Viral genetics, Microbial Control, Drug Resistance, Viral, Genetics, medicine, Humans, Mutation detection, Microbial Pathogens, Mutation Detection, Resistència als medicaments, Pharmacology, Transplantation, business.industry, Organisms, Dideoxy DNA sequencing, Biology and Life Sciences, Computational Biology, Kidneys, Organ Transplantation, Renal System, Genome Analysis, medicine.disease, Virology, Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNA [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Transplant Recipients, Research and analysis methods, Molecular biology techniques, 030104 developmental biology, Mutation, Citomegalovirus, Disease prevention, Antimicrobial Resistance, DNA viruses, Hepatic transplantation, Solid organ transplantation, business
Abstract

[Objetives] The aim of this study was to identify CMV drug resistance mutations (DRM) in solid organ transplant (SOT) recipients with suspected resistance comparing next-generation sequencing (NGS) with Sanger sequencing and assessing risk factors and the clinical impact of resistance., [Methods] Using Sanger sequencing as the reference method, we prospectively assessed the ability of NGS to detect CMV DRM in the UL97 and UL54 genes in a nationwide observational study from September 2013 to August 2016., [Results] Among 44 patients recruited, 14 DRM were detected by Sanger in 12 patients (27%) and 20 DRM were detected by NGS, in 16 (36%). NGS confirmed all the DRM detected by Sanger. The additional six mutations detected by NGS were present in, [Conclusions] NGS showed a higher yield than Sanger sequencing for detecting CMV resistance mutations in SOT recipients. The presence of DRM detected by NGS was independently associated with longer antiviral treatment., M.A.M. was supported in part by: Agency for Health Technology Assessment and Research Supported by Ministerio de Economía y Competitividad, Instituto de Salud Carlos III (PS12/02131 and PI17/02150); Agència de Gestió d´Ajuts Universitaris I de Recerca, Generalitat de Catalunya, 2017 SGR 794; and Fundació Marató TV3 project code 201824.

Published
2019

5. Improvement in detecting cytomegalovirus drug resistance mutations in solid organ transplant recipients with suspected resistance using next generation sequencing

Author

López-Aladid, Rubén, primary, Guiu, Alba, additional, Mosquera, Maria Mar, additional, López-Medrano, Francisco, additional, Cofán, Frederic, additional, Linares, Laura, additional, Torre-Cisneros, Julián, additional, Vidal, Elisa, additional, Moreno, Asunción, additional, Aguado, Jose María, additional, Cordero, Elisa, additional, Martin-Gandul, Cecilia, additional, Carratalá, Jordi, additional, Sabé, Nuria, additional, Niubó, Jordi, additional, Cervera, Carlos, additional, Capón, Alicia, additional, Cervilla, Anna, additional, Santos, Marta, additional, Bodro, Marta, additional, Muñoz, Patricia, additional, Fariñas, Maria Carmen, additional, Antón, Andrés, additional, Aranzamendi, Maitane, additional, Montejo, Miguel, additional, Pérez-Romero, Pilar, additional, Len, Oscar, additional, and Marcos, Maria Ángeles, additional

Published
2019
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6. Improvement in detecting cytomegalovirus drug resistance mutations in solid organ transplant recipients with suspected resistance using next generation sequencing

Author

Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, European Commission, Fundació La Marató de TV3, López-Aladid, Rubén, Guiu, Alba, Mosquera, María Mar, López-Medrano, Francisco, Cofán, Frederic, Linares, Laura, Torre-Cisneros, Julián, Vidal, Elisa, Moreno, Asunción, Aguado, José María, Cordero-Matía, Elisa, Martín-Gandul, Cecilia, Carratalà, Jordi, Sabé, Nuria, Niubó, Nuria, Cervera, Carlos, Capón, Alicia, Cervilla, Anna, Santos, Marta, Bodro, Marta, Muñoz García, Patricia, Fariñas, María del Carmen, Antón, Andrés, Aranzamendi Zaldumbide, Maitane, Montejo, Miguel, Pérez-Romero, Pilar, Len, Óscar, Marcos, María Ángeles, Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, European Commission, Fundació La Marató de TV3, López-Aladid, Rubén, Guiu, Alba, Mosquera, María Mar, López-Medrano, Francisco, Cofán, Frederic, Linares, Laura, Torre-Cisneros, Julián, Vidal, Elisa, Moreno, Asunción, Aguado, José María, Cordero-Matía, Elisa, Martín-Gandul, Cecilia, Carratalà, Jordi, Sabé, Nuria, Niubó, Nuria, Cervera, Carlos, Capón, Alicia, Cervilla, Anna, Santos, Marta, Bodro, Marta, Muñoz García, Patricia, Fariñas, María del Carmen, Antón, Andrés, Aranzamendi Zaldumbide, Maitane, Montejo, Miguel, Pérez-Romero, Pilar, Len, Óscar, and Marcos, María Ángeles

Abstract

[Objetives] The aim of this study was to identify CMV drug resistance mutations (DRM) in solid organ transplant (SOT) recipients with suspected resistance comparing next-generation sequencing (NGS) with Sanger sequencing and assessing risk factors and the clinical impact of resistance., [Methods] Using Sanger sequencing as the reference method, we prospectively assessed the ability of NGS to detect CMV DRM in the UL97 and UL54 genes in a nationwide observational study from September 2013 to August 2016., [Results] Among 44 patients recruited, 14 DRM were detected by Sanger in 12 patients (27%) and 20 DRM were detected by NGS, in 16 (36%). NGS confirmed all the DRM detected by Sanger. The additional six mutations detected by NGS were present in <20% of the sequenced population, being located in the UL97 gene and conferring high-level resistance to ganciclovir. The presence of DRM by NGS was associated with lung transplantation (p = 0.050), the administration of prophylaxis (p = 0.039), a higher mean time between transplantation and suspicion of resistance (p = 0.038) and longer antiviral treatment duration before suspicion (p = 0.024). However, the latter was the only factor independently associated with the presence of DRM by NGS in the multivariate analysis (OR 2.24, 95% CI 1.03 to 4.87)., [Conclusions] NGS showed a higher yield than Sanger sequencing for detecting CMV resistance mutations in SOT recipients. The presence of DRM detected by NGS was independently associated with longer antiviral treatment.

Published
2019

7. Evaluation of a multiplex panel for the diagnosis of acute infectious diarrhea in immunocompromised hematologic patients

Author

Alejo-Cancho, Izaskun, primary, Fernández Avilés, Francesc, additional, Capón, Alicia, additional, Rodríguez, Cristina, additional, Barrachina, Josep, additional, Salvador, Pilar, additional, Valls, Mª Eugenia, additional, Álvarez-Martínez, Miriam J., additional, Zboromyrska, Yuliya, additional, Vila, Jordi, additional, and Marcos, Mª Ángeles, additional

Published
2017
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8. Zika Virus Screening among Spanish Team Members After 2016 Rio de Janeiro, Brazil, Olympic Games

Author

Rodriguez-Valero, Natalia, primary, Borobia, Alberto M., additional, Lago, Mar, additional, Sánchez-Seco, Maria Paz, additional, de Ory, Fernando, additional, Vázquez, Ana, additional, Pérez-Arellano, Jose Luis, additional, Rodríguez, Cristina Carranza, additional, Martínez, Miguel J., additional, Capón, Alicia, additional, Cañas, Elias, additional, Salas-Coronas, Joaquin, additional, Galparsoro, Arkaitz Azcune, additional, and Muñoz, Jose, additional

Published
2017
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