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2. Infectious Toscana Virus in Seminal Fluid of Young Man Returning from Elba Island, Italy

Author

Matusali, Giulia, D'Abramo, Alessandra, Terrosi, Chiara, Carletti, Fabrizio, Colavita, Francesca, Vairo, Francesco, Savellini, Gianni Gori, Gandolfo, Claudia, Anichini, Gabriele, Lalle, Eleonora, Bordi, Licia, Corpolongo, Angela, Maritti, Micaela, Marchioni, Luisa, Capobianchi, Maria Rosaria, Castilletti, Concetta, Cusi, Maria Grazia, and Nicastri, Emanuele

Subjects
Semen -- Case studies -- Health aspects, Bunyaviruses -- Case studies -- Identification and classification, RNA virus infections -- Case studies -- Risk factors -- Diagnosis, Viral meningitis -- Case studies -- Risk factors -- Diagnosis, Health
Abstract

Toscana virus (TOSV) is an arthropodborne virus, belonging to the genus Phlebovirus, that was first isolated in Monte Argentario in 1971 from the sand flies Phlebotomus perniciosus and P. perfiliewi [...]

Published
2022
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3. Full Genome Characterization of the First Oropouche Virus Isolate Imported in Europe from Cuba.

Author

Deiana, Michela, Malagò, Simone, Mori, Antonio, Accordini, Silvia, Matucci, Andrea, Passarelli Mantovani, Rebeca, Gianesini, Natasha, Huits, Ralph, Piubelli, Chiara, Gobbi, Federico Giovanni, Capobianchi, Maria Rosaria, and Castilletti, Concetta

Subjects
WHOLE genome sequencing, EMERGING infectious diseases, GENETIC variation, GENOMES, GENOTYPES
Abstract

On 27 May 2024, the Cuban Ministry of Health reported the first outbreak of Oropouche fever on the island. The etiologic agent, Oropouche virus (OROV), is a poorly understood arbovirus that has been known since the 1960s and represents a public health burden in Latin America. We report the whole-genome characterization of the first European OROV isolate from a returning traveler from Cuba with Oropouche fever-like symptoms. The isolate was obtained from the patient's serum; whole-genome sequencing was performed by next-generation sequencing, followed by phylogenetic analysis and genetic variability studies. The analysis showed that the most closely related sequence was from the French Guiana 2020 outbreak. Interestingly, our isolate is a reassortant virus, included in a highly supported monophyletic clade containing recent OROV cases (Brazil 2015–Colombia 2021), separated from the other four previously known genotypes. More deeply, it was found to be included in a distinct branch containing the sequences of the Brazil 2022–2024 outbreak. The reassortment event involved the S and L segments, which have high similarity with sequences belonging to a new cluster (here defined as OROV_SCDC_2024), while the M segment shows high similarity with older sequences. These results likely describe the viral strain responsible for the current outbreak in Cuba, which may also reflect the ongoing outbreak in Latin America. Further studies are needed to understand how OROV evolves towards traits that facilitate its spread and adaptation outside its original basin, and to track its spread and evolution in the European continent. [ABSTRACT FROM AUTHOR]

Published
2024
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5. COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models

Author

Conforti, Antonella, Marra, Emanuele, Palombo, Fabio, Roscilli, Giuseppe, Ravà, Micol, Fumagalli, Valeria, Muzi, Alessia, Maffei, Mariano, Luberto, Laura, Lione, Lucia, Salvatori, Erika, Compagnone, Mirco, Pinto, Eleonora, Pavoni, Emiliano, Bucci, Federica, Vitagliano, Grazia, Stoppoloni, Daniela, Pacello, Maria Lucrezia, Cappelletti, Manuela, Ferrara, Fabiana Fosca, D’Acunto, Emanuela, Chiarini, Valerio, Arriga, Roberto, Nyska, Abraham, Di Lucia, Pietro, Marotta, Davide, Bono, Elisa, Giustini, Leonardo, Sala, Eleonora, Perucchini, Chiara, Paterson, Jemma, Ryan, Kathryn Ann, Challis, Amy-Rose, Matusali, Giulia, Colavita, Francesca, Caselli, Gianfranco, Criscuolo, Elena, Clementi, Nicola, Mancini, Nicasio, Groß, Rüdiger, Seidel, Alina, Wettstein, Lukas, Münch, Jan, Donnici, Lorena, Conti, Matteo, De Francesco, Raffaele, Kuka, Mirela, Ciliberto, Gennaro, Castilletti, Concetta, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Guidotti, Luca G., Rovati, Lucio, Iannacone, Matteo, and Aurisicchio, Luigi

Published
2022
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7. Persistent Spike-specific T cell immunity despite antibody reduction after 3 months from SARS-CoV-2 BNT162b2-mRNA vaccine

Author

Agrati, Chiara, Castilletti, Concetta, Goletti, Delia, Sacchi, Alessandra, Bordoni, Veronica, Mariotti, Davide, Notari, Stefania, Matusali, Giulia, Meschi, Silvia, Petrone, Linda, Aiello, Alessandra, Najafi Fard, Saeid, Farroni, Chiara, Colavita, Francesca, Lapa, Daniele, Leone, Sara, Agresta, Alessandro, Capobianchi, Maria, Ippolito, Giuseppe, Vaia, Francesco, and Puro, Vincenzo

Published
2022
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10. Wide Real-Life Data Support Reduced Sensitivity of Antigen Tests for Omicron SARS-CoV-2 Infections

Author

Piubelli, Chiara, primary, Treggiari, Davide, additional, Lavezzari, Denise, additional, Deiana, Michela, additional, Dishnica, Klevia, additional, Tosato, Emma Maria Sole, additional, Mazzi, Cristina, additional, Cattaneo, Paolo, additional, Mori, Antonio, additional, Pomari, Elena, additional, Nicolini, Lavinia, additional, Leonardi, Martina, additional, Perandin, Francesca, additional, Formenti, Fabio, additional, Giorgetti, Alejandro, additional, Conti, Antonio, additional, Capobianchi, Maria Rosaria, additional, Gobbi, Federico Giovanni, additional, and Castilletti, Concetta, additional

Published
2024
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11. Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

Author

Miersch, Shane, Li, Zhijie, Saberianfar, Reza, Ustav, Mart, Brett Case, James, Blazer, Levi, Chen, Chao, Ye, Wei, Pavlenco, Alevtina, Gorelik, Maryna, Garcia Perez, Julia, Subramania, Suryasree, Singh, Serena, Ploder, Lynda, Ganaie, Safder, Chen, Rita E., Leung, Daisy W., Pandolfi, Pier Paolo, Novelli, Giuseppe, Matusali, Giulia, Colavita, Francesca, Capobianchi, Maria R., Jain, Suresh, Gupta, J.B., Amarasinghe, Gaya K., Diamond, Michael S., Rini, James, and Sidhu, Sachdev S.

Published
2021
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12. Immunogenicity of a new gorilla adenovirus vaccine candidate for COVID-19

Author

Capone, Stefania, Raggioli, Angelo, Gentile, Michela, Battella, Simone, Lahm, Armin, Sommella, Andrea, Contino, Alessandra Maria, Urbanowicz, Richard A., Scala, Romina, Barra, Federica, Leuzzi, Adriano, Lilli, Eleonora, Miselli, Giuseppina, Noto, Alessia, Ferraiuolo, Maria, Talotta, Francesco, Tsoleridis, Theocharis, Castilletti, Concetta, Matusali, Giulia, Colavita, Francesca, Lapa, Daniele, Meschi, Silvia, Capobianchi, Maria, Soriani, Marco, Folgori, Antonella, Ball, Jonathan K., Colloca, Stefano, and Vitelli, Alessandra

Published
2021
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14. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Abbonizio, Maria Alessandra, Abdeddaim, Amina, Agostini, Elisabetta, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonica, Maria Assunta, Antonini, Mario, Bartoli, Tommaso Ascoli, Baldini, Francesco, Barbaro, Raffaella, Bartolini, Barbara, Bellagamba, Rita, Benigni, Martina, Bevilacqua, Nazario, Biava, Gianluigi, Bibas, Michele, Bordi, Licia, Bordoni, Veronica, Boumis, Evangelo, Branca, Marta, Buonomo, Rosanna, Busso, Donatella, Camici, Marta, Campioni, Paolo, Canichella, Flaminia, Capobianchi, Maria Rosaria, Capone, Alessandro, Caporale, Cinzia, Caraffa, Emanuela, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Cataldo, Adriana, Cerilli, Stefano, Cerva, Carlotta, Chiappini, Roberta, Chinello, Pierangelo, Cianfarani, Maria Assunta, Ciaralli, Carmine, Cimaglia, Claudia, Cinicola, Nicola, Ciotti, Veronica, Cicalini, Stefania, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, De Palo, Maria Grazia, De Zottis, Federico, Di Bari, Virginia, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Donno, Davide, Evangelista, Francesca, Faraglia, Francesca, Farina, Anna, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Fusetti, Matteo, Galati, Vincenzo, Gagliardini, Roberta, Gallì, Paola, Garotto, Gabriele, Gaviano, Ilaria, Tekle, Saba Gebremeskel, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Granata, Guido, Greci, Maria Cristina, Grilli, Elisabetta, Grisetti, Susanna, Gualano, Gina, Iacomi, Fabio, Iaconi, Marta, Iannicelli, Giuseppina, Inversi, Carlo, Ippolito, Giuseppe, Lalle, Eleonora, Lamanna, Maria Elena, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Libertone, Raffaella, Lionetti, Raffaella, Liuzzi, Giuseppina, Loiacono, Laura, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Maffongelli, Gaetano, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Mastrobattista, Annelisa, Mastrorosa, Ilaria, Matusali, Giulia, Mazzotta, Valentina, Mencarini, Paola, Meschi, Silvia, Messina, Francesco, Micarelli, Sibiana, Mogavero, Giulia, Mondi, Annalisa, Montalbano, Marzia, Montaldo, Chiara, Mosti, Silvia, Murachelli, Silvia, Musso, Maria, Nardi, Michela, Navarra, Assunta, Nicastri, Emanuele, Nocioni, Martina, Noto, Pasquale, Noto, Roberto, Oliva, Alessandra, Onnis, Ilaria, Ottou, Sandrine, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Palombi, Giulio, Pareo, Carlo, Passeri, Virgilio, Pelliccioni, Federico, Penna, Giovanna, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pinnetti, Carmela, Pisciotta, Maria, Piselli, Pierluca, Pittalis, Silvia, Pontarelli, Agostina, Proietti, Costanza, Puro, Vincenzo, Ramazzini, Paolo Migliorisi, Rianda, Alessia, Rinonapoli, Gabriele, Rosati, Silvia, Rubino, Dorotea, Rueca, Martina, Ruggeri, Alberto, Sacchi, Alessandra, Sampaolesi, Alessandro, Sanasi, Francesco, Santagata, Carmen, Scarabello, Alessandra, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Strano, Giacomo, Taglietti, Fabrizio, Taibi, Chiara, Taloni, Giorgia, Nardi, Tetaj, Tonnarini, Roberto, Topino, Simone, Tozzi, Martina, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vergori, Alessandra, Vincenzi, Laura, Visco-Comandini, Ubaldo, Vita, Serena, Vittozzi, Pietro, Zaccarelli, Mauro, Zanetti, Antonella, Zito, Sara, Lorenzini, Patrizia, Di Gennaro, Francesco, and Girardi, Enrico

Published
2021
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16. Extremely potent human monoclonal antibodies from COVID-19 convalescent patients

Author

Andreano, Emanuele, Nicastri, Emanuele, Paciello, Ida, Pileri, Piero, Manganaro, Noemi, Piccini, Giulia, Manenti, Alessandro, Pantano, Elisa, Kabanova, Anna, Troisi, Marco, Vacca, Fabiola, Cardamone, Dario, De Santi, Concetta, Torres, Jonathan L., Ozorowski, Gabriel, Benincasa, Linda, Jang, Hyesun, Di Genova, Cecilia, Depau, Lorenzo, Brunetti, Jlenia, Agrati, Chiara, Capobianchi, Maria Rosaria, Castilletti, Concetta, Emiliozzi, Arianna, Fabbiani, Massimiliano, Montagnani, Francesca, Bracci, Luisa, Sautto, Giuseppe, Ross, Ted M., Montomoli, Emanuele, Temperton, Nigel, Ward, Andrew B., Sala, Claudia, Ippolito, Giuseppe, and Rappuoli, Rino

Published
2021
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20. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Abbonizio, Maria Alessandra, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Di Stefano, Federica, Eskild, Petersen, and Zumla, Alimuddin

Published
2020
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22. Liver transplant recipients and prioritization of anti‐HCV therapy: an Italian cohort analysis

Author

Lanini, Simone, Nanni Costa, Alessandro, Grossi, Paolo A, Procaccio, Francesco, Ricci, Andrea, Capobianchi, Maria R, Terrault, Norah A, and Ippolito, Giuseppe

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Liver Disease, Emerging Infectious Diseases, Chronic Liver Disease and Cirrhosis, Infectious Diseases, Transplantation, Organ Transplantation, Hepatitis - C, Hepatitis, Clinical Research, Digestive Diseases, Good Health and Well Being, Antiviral Agents, Biomarkers, Cohort Studies, End Stage Liver Disease, Female, Health Priorities, Hepacivirus, Hepatitis C, Hepatitis C Antibodies, Humans, Italy, Liver Transplantation, Male, Multivariate Analysis, Patient Selection, Risk Factors, Time Factors, Treatment Failure, Virus Activation, Donor-recipient age difference, donor-recipient sex matching, liver graft failure, MELD score, multicentre study, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background and aimsIn patients with hepatitis C virus (HCV), recurrence of infection after liver transplant (LT) is universal and associated with worst survival. We present the results of an Italian cohort to compare the 3-year outcome of HCV-Ab-positive and HCV-Ab-negative LT recipients and to assess the potential interaction between HCV-Ab sero-status and other risk factors for LT failure.MethodsThe study is a multicentre cohort including a sample of liver transplant centres. Participant's information was collected at the local level. The best functional form of variables was decided according to the objective methods based on information theory. Association between transplant failure and potential risk factors was assessed in univariate and multivariate Poisson regression model with random intercept.ResultsBetween June 2007 and May 2009, 1164 LT recipients were enrolled in 16 Italian transplant centres, of them 275 (23.63%) experienced LT failure. Incidence rates of LT failure was 0.32 and 0.23 per 1000 person-days in HCV-Ab-positive and HCV-Ab-negative recipients respectively (P = 0.003). Inferential models according to Akaike information criterion indicated that donor-recipient age difference and donor-recipient sex matching were more informative to predict LT failure than the age and the sex as separate variables. Multivariate analysis provided evidence that HCV-Ab sero-status, time after LT, donor-recipient age difference, donor-recipient sex matching and recipient's MELD score were significantly associated with LT failure. Moreover, the effect of HCV-Ab sero-status on LT failure was modified by the simultaneous action of time after LT and donor-recipient age difference. No interaction was found between recipient's HCV-Ab sero-status and either recipient's MELD or donor-recipient sex matching.ConclusionIn view of the imminent introduction of new anti-HCV therapies, our study provides information to assess which LT recipients should be prioritized for receiving these highly effective, but expensive, new treatments. This is particularly relevant for those clinical settings where healthcare prioritization is endorsed by national authorities.

Published
2016

23. Humoral- and T-Cell–Specific Immune Responses to SARS-CoV-2 mRNA Vaccination in Patients With MS Using Different Disease-Modifying Therapies

Author

Tortorella, Carla, Aiello, Alessandra, Gasperini, Claudio, Agrati, Chiara, Castilletti, Concetta, Ruggieri, Serena, Meschi, Silvia, Matusali, Giulia, Colavita, Francesca, Farroni, Chiara, Cuzzi, Gilda, Cimini, Eleonora, Tartaglia, Eleonora, Vanini, Valentina, Prosperini, Luca, Haggiag, Shalom, Galgani, Simona, Quartuccio, Maria Esmeralda, Salmi, Andrea, Repele, Federica, Gerarda Altera, Anna Maria, Cristofanelli, Flavia, DʼAbramo, Alessandra, Bevilacqua, Nazario, Corpolongo, Angela, Puro, Vincenzo, Vaia, Francesco, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Nicastri, Emanuele, and Goletti, Delia

Published
2021
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24. SARS-CoV-2 Phylogenetic Analysis, Lazio Region, Italy, February-March 2020

Author

Bartolini, Barbara, Rueca, Martina, Gruber, Cesare Ernesto Maria, Messina, Francesco, Carletti, Fabrizio, Giombini, Emanuela, Lalle, Eleonora, Bordi, Licia, Matusali, Giulia, Colavita, Francesca, Castilletti, Concetta, Vairo, Francesco, Ippolito, Giuseppe, Capobianchi, Maria Rosaria, and Caro, Antonino Di

Subjects
Severe acute respiratory syndrome -- Health aspects -- Analysis, Coronaviruses -- Analysis -- Health aspects, Phylogeny -- Analysis -- Health aspects, Epidemiology -- Analysis -- Health aspects, COVID-19 -- Analysis -- Health aspects, Health
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised serious concerns because of its rapid dissemination worldwide. Italy is one of the countries with the highest number of coronavirus disease [...]

Published
2020
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25. Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

Author

Agrati, Chiara, Sacchi, Alessandra, Bordoni, Veronica, Cimini, Eleonora, Notari, Stefania, Grassi, Germana, Casetti, Rita, Tartaglia, Eleonora, Lalle, Eleonora, D’Abramo, Alessandra, Castilletti, Concetta, Marchioni, Luisa, Shi, Yufang, Mariano, Andrea, Song, Jin-Wen, Zhang, Ji-Yuan, Wang, Fu-Sheng, Zhang, Chao, Fimia, Gian Maria, Capobianchi, Maria R., Piacentini, Mauro, Antinori, Andrea, Nicastri, Emanuele, Maeurer, Markus, Zumla, Alimuddin, and Ippolito, Giuseppe

Published
2020
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26. Multi-omics approach to COVID-19: a domain-based literature review

Author

Montaldo, Chiara, Messina, Francesco, Abbate, Isabella, Antonioli, Manuela, Bordoni, Veronica, Aiello, Alessandra, Ciccosanti, Fabiola, Colavita, Francesca, Farroni, Chiara, Najafi Fard, Saeid, Giombini, Emanuela, Goletti, Delia, Matusali, Giulia, Rozera, Gabriella, Rueca, Martina, Sacchi, Alessandra, Piacentini, Mauro, Agrati, Chiara, Fimia, Gian Maria, Capobianchi, Maria Rosaria, Lauria, Francesco Nicola, and Ippolito, Giuseppe

Published
2021
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29. Exploring Viral Genome Profile in Mpox Patients during the 2022 Outbreak, in a North-Eastern Centre of Italy.

Author

Deiana, Michela, Lavezzari, Denise, Mori, Antonio, Accordini, Silvia, Pomari, Elena, Piubelli, Chiara, Malagò, Simone, Cordioli, Maddalena, Ronzoni, Niccolò, Angheben, Andrea, Tacconelli, Evelina, Capobianchi, Maria Rosaria, Gobbi, Federico Giovanni, and Castilletti, Concetta

Subjects
VIRAL genomes, MONKEYPOX, SINGLE nucleotide polymorphisms, WHOLE genome sequencing, COEXISTENCE of species, GENETIC variation
Abstract

In 2022, an unprecedented outbreak of mpox raged in several nations. Sequences from the 2022 outbreak reveal a higher nucleotide substitution if compared with the estimated rate for orthopoxviruses. Recently, intra-lesion SNVs (single nucleotide variants) have been described, and these have been suggested as possible sources of genetic variation. Until now, it has not been clear if the presence of several SNVs could represents the result of local mutagenesis or a possible co-infection. We investigated the significance of SNVs through whole-genome sequencing analysis of four unrelated mpox cases. In addition to the known mutations harboured by the circulating strains of virus (MPXV), 7 novel mutations were identified, including SNVs located in genes that are involved in immune evasion mechanisms and/or viral fitness, six of these appeared to be APOBEC3-driven. Interestingly, three patients exhibited the coexistence of mutated and wild-type alleles for five non-synonymous variants. In addition, two patients, apparently unrelated, showed an analogous pattern for two novel mutations, albeit with divergent frequencies. The coexistence of mixed viral populations, harbouring non-synonymous mutations in patients, supports the hypothesis of possible co-infection. Additional investigations of larger clinical cohorts are essential to validating intra-patient viral genome heterogeneity and determining the possibility of co-presence events of slightly divergent MPXV strains. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Relationship Between Viremia and Specific Organ Damage in Ebola Patients : A Cohort Study

Author

INMI-EMERGENCY EBOV Sierra Leone Study Group, Lanini, Simone, Portella, Gina, Vairo, Francesco, Kobinger, Gary P., Pesenti, Antonio, Langer, Martin, Kabia, Soccoh, Brogiato, Giorgio, Amone, Jackson, Castilletti, Concetta, Miccio, Rossella, Capobianchi, Maria Rosaria, Strada, Gino, Zumla, Alimuddin, Di Caro, Antonino, and Ippolito, Giuseppe

Published
2018

31. Emerging Zika Virus Infection: A Rapidly Evolving Situation

Author

Bordi, Licia, Avsic-Zupanc, Tatjana, Lalle, Eleonora, Vairo, Francesco, Rosaria Capobianchi, Maria, da Costa Vasconcelos, Pedro Fernando, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, Rezza, Giovanni, editor, and Ippolito, Giuseppe, editor

Published
2017
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32. Enabling Rapid Response to the 2014–2016 Ebola Epidemic: The Experience and the Results of the National Institute for Infectious Diseases Lazzaro Spallanzani

Author

Nicastri, Emanuele, Castilletti, Concetta, Biava, Mirella, Fusco, Francesco Maria, Petrosillo, Nicola, Puro, Vincenzo, Lauria, Francesco Nicola, Capobianchi, Maria Rosaria, Di Caro, Antonino, Ippolito, Giuseppe, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, Rezza, Giovanni, editor, and Ippolito, Giuseppe, editor

Published
2017
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33. Inhibition of HECT E3 ligases as potential therapy for COVID-19

Author

Novelli, Giuseppe, Liu, Jing, Biancolella, Michela, Alonzi, Tonino, Novelli, Antonio, Patten, J. J., Cocciadiferro, Dario, Agolini, Emanuele, Colona, Vito Luigi, Rizzacasa, Barbara, Giannini, Rosalinda, Bigio, Benedetta, Goletti, Delia, Capobianchi, Maria Rosaria, Grelli, Sandro, Mann, Justin, McKee, Trevor D., Cheng, Ke, Amanat, Fatima, Krammer, Florian, Guarracino, Andrea, Pepe, Gerardo, Tomino, Carlo, Tandjaoui-Lambiotte, Yacine, Uzunhan, Yurdagul, Tubiana, Sarah, Ghosn, Jade, Notarangelo, Luigi D., Su, Helen C., Abel, Laurent, Cobat, Aurélie, Elhanan, Gai, Grzymski, Joseph J., Latini, Andrea, Sidhu, Sachdev S., Jain, Suresh, Davey, Robert A., Casanova, Jean-Laurent, Wei, Wenyi, and Pandolfi, Pier Paolo

Published
2021
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35. Comparative analysis of bioinformatics tools to characterize SARS-CoV-2 subgenomic RNAs

Author

Lavezzari, Denise, primary, Mori, Antonio, additional, Pomari, Elena, additional, Deiana, Michela, additional, Fadda, Antonio, additional, Bertoli, Luca, additional, Sinigaglia, Alessandro, additional, Riccetti, Silvia, additional, Barzon, Luisa, additional, Piubelli, Chiara, additional, Delledonne, Massimo, additional, Capobianchi, Maria Rosaria, additional, and Castilletti, Concetta, additional

Published
2023
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38. Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome

Author

Sacchi, Alessandra, Grassi, Germana, Bordoni, Veronica, Lorenzini, Patrizia, Cimini, Eleonora, Casetti, Rita, Tartaglia, Eleonora, Marchioni, Luisa, Petrosillo, Nicola, Palmieri, Fabrizio, D’Offizi, Gianpiero, Notari, Stefania, Tempestilli, Massimo, Capobianchi, Maria Rosaria, Nicastri, Emanuele, Maeurer, Markus, Zumla, Alimuddin, Locatelli, Franco, Antinori, Andrea, Ippolito, Giuseppe, and Agrati, Chiara

Published
2020
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41. A collaborative study to establish the 1st WHO International Standard for human cytomegalovirus for nucleic acid amplification technology

Author

Kessler, Harald, Rawlinson, William, Boivin, Guy, Preiksaitis, Jutta, Pang, Xiao-Li, Barranger, Côme, Alain, Sophie, Bressollette-Bodin, Céline, Hamprecht, Klaus, Grewing, Thomas, Constantoulakis, Pantelis, Ghisetti, Valeria, Capobianchi, Maria R., Abbate, Isabella, Olivo, Cristina, Lazzarotto, Tiziana, Baldanti, Fausto, Inoue, Naoki, Müller, Fredrik, Corcoran, Craig, Hardie, Diana, Prieto, Jacqueline, Schuurman, Rob, van Loon, Anton, Ho, Shiaolan, Hillyard, David, Hodinka, Richard, Louise Landry, Marie, Caliendo, Angela, Lurain, Nell, Sung, Lee, Gulley, Margaret, Atkinson, Claire, Bible, Jon, Guiver, Malcolm, Fryer, Jacqueline F., Heath, Alan B., and Minor, Philip D.

Published
2016
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42. No metagenomic evidence of tumorigenic viruses in cancers from a selected cohort of immunosuppressed subjects

Author

Passaro, Nunzia, Casagrande, Andrea, Chiara, Matteo, Fosso, Bruno, Manzari, Caterina, D’Erchia, Anna Maria, Iesari, Samuele, Pisani, Francesco, Famulari, Antonio, Tulissi, Patrizia, Mastrosimone, Stefania, Maresca, Maria Cristina, Mercante, Giuseppe, Spriano, Giuseppe, Corrado, Giacomo, Vizza, Enrico, Garbuglia, Anna Rosa, Capobianchi, Maria Rosaria, Mottini, Carla, Cenci, Alessandra, Tartaglia, Marco, Costa, Alessandro Nanni, Pesole, Graziano, and Crescenzi, Marco

Published
2019
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44. Tracking the Selective Pressure Profile and Gene Flow of SARS-CoV-2 Delta Variant in Italy from April to October 2021 and Frequencies of Key Mutations from Three Representative Italian Regions.

Author

Lo Presti, Alessandra, Di Martino, Angela, Ambrosio, Luigina, De Sabato, Luca, Knijn, Arnold, Vaccari, Gabriele, Di Bartolo, Ilaria, Morabito, Stefano, Terregino, Calogero, Fusaro, Alice, Monne, Isabella, Giussani, Edoardo, Tramuto, Fabio, Maida, Carmelo Massimo, Mazzucco, Walter, Costantino, Claudio, Rueca, Martina, Giombini, Emanuela, Gruber, Cesare Ernesto Maria, and Capobianchi, Maria Rosaria

Subjects
SARS-CoV-2 Delta variant, COVID-19, PROTEIN stability, GENE flow, VIRAL mutation, GENETIC mutation
Abstract

The SARS-CoV-2 Delta variant of concern (VOC) was often associated with serious clinical course of the COVID-19 disease. Herein, we investigated the selective pressure, gene flow and evaluation on the frequencies of mutations causing amino acid substitutions in the Delta variant in three Italian regions. A total of 1500 SARS-CoV-2 Delta genomes, collected in Italy from April to October 2021 were investigated, including a subset of 596 from three Italian regions. The selective pressure and the frequency of amino acid substitutions and the prediction of their possible impact on the stability of the proteins were investigated. Delta variant dataset, in this study, identified 68 sites under positive selection: 16 in the spike (23.5%), 11 in nsp2 (16.2%) and 10 in nsp12 (14.7%) genes. Three of the positive sites in the spike were located in the receptor-binding domain (RBD). In Delta genomes from the three regions, 6 changes were identified as very common (>83.7%), 4 as common (>64.0%), 21 at low frequency (2.1%–25.0%) and 29 rare (≤2.0%). The detection of positive selection on key mutations may represent a model to identify recurrent signature mutations of the virus. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Enterovirus D68-Associated Acute Flaccid Myelitis in Immunocompromised Woman, Italy

Author

Giombini, Emanuela, Rueca, Martina, Barberi, Walter, Iori, Anna Paola, Inghilleri, Maurizio, Castilletti, Concetta, Scognamiglio, Paola, Vairo, Francesco, Ippolito, Giuseppe, Capobianchi, Maria Rosaria, and Valli, Maria Beatrice

Subjects
Myelitis -- Diagnosis -- Care and treatment -- Case studies, Enterovirus diseases -- Case studies -- Diagnosis -- Care and treatment, Health
Abstract

Enteroviruses are the most common viruses circulating worldwide and lead to a broad spectrum of clinical illnesses: respiratory infection; hand, foot, and mouth disease; acute and chronic cardiac disease; meningitis; [...]

Published
2017
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