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328 results on '"Capon RJ"'

1. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

Author

McAlpine, JB, Chen, SN, Kutateladze, A, Macmillan, JB, Appendino, G, Barison, A, Beniddir, MA, Biavatti, MW, Bluml, S, Boufridi, A, Butler, MS, Capon, RJ, Choi, YH, Coppage, D, Crews, P, Crimmins, MT, Csete, M, Dewapriya, P, Egan, JM, Garson, MJ, Genta-Jouve, G, Gerwick, WH, Gross, H, Harper, MK, Hermanto, P, Hook, JM, Hunter, L, Jeannerat, D, Ji, NY, Johnson, TA, Kingston, DGI, Koshino, H, Lee, HW, Lewin, G, Li, J, Linington, RG, Liu, M, McPhail, KL, Molinski, TF, Moore, BS, Nam, JW, Neupane, RP, Niemitz, M, Nuzillard, JM, Oberlies, NH, Ocampos, FMM, Pan, G, Quinn, RJ, Reddy, DS, Renault, JH, Rivera-Chávez, J, Robien, W, Saunders, CM, Schmidt, TJ, Seger, C, Shen, B, Steinbeck, C, Stuppner, H, Sturm, S, Taglialatela-Scafati, O, Tantillo, DJ, Verpoorte, R, Wang, BG, Williams, CM, Williams, PG, Wist, J, Yue, JM, Zhang, C, Xu, Z, Simmler, C, Lankin, DC, Bisson, J, Pauli, GF, McAlpine, JB, Chen, SN, Kutateladze, A, Macmillan, JB, Appendino, G, Barison, A, Beniddir, MA, Biavatti, MW, Bluml, S, Boufridi, A, Butler, MS, Capon, RJ, Choi, YH, Coppage, D, Crews, P, Crimmins, MT, Csete, M, Dewapriya, P, Egan, JM, Garson, MJ, Genta-Jouve, G, Gerwick, WH, Gross, H, Harper, MK, Hermanto, P, Hook, JM, Hunter, L, Jeannerat, D, Ji, NY, Johnson, TA, Kingston, DGI, Koshino, H, Lee, HW, Lewin, G, Li, J, Linington, RG, Liu, M, McPhail, KL, Molinski, TF, Moore, BS, Nam, JW, Neupane, RP, Niemitz, M, Nuzillard, JM, Oberlies, NH, Ocampos, FMM, Pan, G, Quinn, RJ, Reddy, DS, Renault, JH, Rivera-Chávez, J, Robien, W, Saunders, CM, Schmidt, TJ, Seger, C, Shen, B, Steinbeck, C, Stuppner, H, Sturm, S, Taglialatela-Scafati, O, Tantillo, DJ, Verpoorte, R, Wang, BG, Williams, CM, Williams, PG, Wist, J, Yue, JM, Zhang, C, Xu, Z, Simmler, C, Lankin, DC, Bisson, J, and Pauli, GF

Abstract

Covering: up to 2018 With contributions from the global natural product (NP) research community, and continuing the Raw Data Initiative, this review collects a comprehensive demonstration of the immense scientific value of disseminating raw nuclear magnetic resonance (NMR) data, independently of, and in parallel with, classical publishing outlets. A comprehensive compilation of historic to present-day cases as well as contemporary and future applications show that addressing the urgent need for a repository of publicly accessible raw NMR data has the potential to transform natural products (NPs) and associated fields of chemical and biomedical research. The call for advancing open sharing mechanisms for raw data is intended to enhance the transparency of experimental protocols, augment the reproducibility of reported outcomes, including biological studies, become a regular component of responsible research, and thereby enrich the integrity of NP research and related fields.

Published
2019

2. Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

Author

Overman, J, Fontaine, F, Moustaqil, M, Mittal, D, Sierecki, E, Sacilotto, N, Zuegg, J, Robertson, AAB, Holmes, K, Salim, AA, Mamidyala, S, Butler, MS, Robinson, AS, Lesieur, E, Johnston, W, Alexandrov, K, Black, BL, Hogan, BM, De Val, S, Capon, RJ, Carroll, JS, Bailey, TL, Koopman, P, Jauch, R, Smyth, MJ, Cooper, MA, Gambin, Y, Francois, M, Overman, J, Fontaine, F, Moustaqil, M, Mittal, D, Sierecki, E, Sacilotto, N, Zuegg, J, Robertson, AAB, Holmes, K, Salim, AA, Mamidyala, S, Butler, MS, Robinson, AS, Lesieur, E, Johnston, W, Alexandrov, K, Black, BL, Hogan, BM, De Val, S, Capon, RJ, Carroll, JS, Bailey, TL, Koopman, P, Jauch, R, Smyth, MJ, Cooper, MA, Gambin, Y, and Francois, M

Abstract

© Overman et al. Pharmacological targeting of transcription factors holds great promise for the development of new therapeutics, but strategies based on blockade of DNA binding, nuclear shuttling, or individual protein partner recruitment have yielded limited success to date. Transcription factors typically engage in complex interaction networks, likely masking the effects of specifically inhibiting single protein-protein interactions. Here, we used a combination of genomic, proteomic and biophysical methods to discover a suite of protein-protein interactions involving the SOX18 transcription factor, a known regulator of vascular development and disease. We describe a small-molecule that is able to disrupt a discrete subset of SOX18-dependent interactions. This compound selectively suppressed SOX18 transcriptional outputs in vitro and interfered with vascular development in zebrafish larvae. In a mouse pre-clinical model of breast cancer, treatment with this inhibitor significantly improved survival by reducing tumour vascular density and metastatic spread. Our studies validate an interactome-based molecular strategy to interfere with transcription factor activity, for the development of novel disease therapeutics.

Published
2017

48. Two Epimeric Dibromo Nitriles From the Australian Sponge Aplysina laevis

Author

Capon, RJ and Macleod, JK

Abstract

Two dibromo nitriles, (1′R,5′S,6′S)-2-(3′,5′-dibromo-1′,6′-dihydroxy-4′-oxocyclohex-2′- enyl) acetonitrile (5) and the (l′R,5′R,6′S) epimer (6), possessing antimicrobial activity, have been isolated from the sponge Aplysina laevis (Carter). Cometabolites (+)-aeroplysinin-1 (1) and the dibromo ketone (2) were also identified. Structures (5) and (6) were assigned on the basis of spectroscopic evidence and synthesis from (1).

Published
1987
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49. Bryotoxins B and C, Toxic Bufadienolide Orthoacetates From the Flowers of Bryophyllum Tubiflorum (Crassulaceae)

Author

Capon, RJ, Macleod, JK, and Oelrichs, PB

Abstract

A mixture of bryotoxins B and C, two new toxins from the flowers of Bryophyllum tubiflorum, was resolved after acetylation and semipreparative silica h.p.l.c . Spectroscopic analysis of the isolated acetates resulted in identification of the toxins as the bufadienolide orthoacetates (3) and (4).

Published
1986
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50. Chemotaxonomy of marine sponges: Families Microcionidae, Raspailiidae and Axinellidae, and their relationships with other families in the orders Poecilosclerida and Axinellida (Porifera : Demospongiae)

Author

Hooper, JNA, Capon, RJ, Keenan, CP, Parry, DL, and Smit, N

Abstract

Biochemical studies on 72 species of marine sponges from tropical Australia showed that 42 of 132 biochemical characters were useful in describing relationships between the families Microcionidae, Raspailiidae and Axinellidae, and other members of the orders Poecilosclerida and Axinellida. Chemotaxonomic characters were obtained from profiles of free amino acids (34 species), carotenoid pigments (41 species), general proteins (62 species) and antibiotic activity against three human pathogens (42 species of sponges). Biochemical data essentially supported the existing division within class Demospongiae, i.e. Ceractinomorpha and Tetractinomorpha, with the notable exception that the 'tetractinomorph' families Raspailiidae and two genera of Axinellidae were found to be more closely related to the Ceractinomorpha. Within-group comparisons demonstrated that Microcionidae (14 species) and Raspailiidae (15 species) were relatively homogeneous in their biochemical profiles, indicating that they should remain separated at the family level, supporting similar conclusions based on morphological data. Similar trends were also shown for the families Desmacellidae (2 species) and Desmoxyidae (3 species), contrary to recent taxonomic revisions by other authors who hypothesised that these families might be heterogenous. Conversely, Axinellidae (27 species) contained at least three disparate groups of genera: one (i.e. Phakellia, Reniochalina) showing strong affinities with ceractinomorphs, a second (i.e. Acanthella, Pseudaxinyssa) and possibly a third (i.e. Axinella, Teichaxinella) showing closer similarities to Desmoxyidae, Hemiasterellidae and outgroups from Hadromerida and 'Lithistida'. These results provided a measure of support for the removal of Raspailiidae to Poecilosclerida, and the division of Axinellidae into several families, as proposed independently in recent revisions based on morphological evidence.

Published
1992
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