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14 results on '"Caporali, Sabrina"'

5. OTX Genes in Adult Tissues.

Author

Terrinoni, Alessandro, Micheloni, Giovanni, Moretti, Vittoria, Caporali, Sabrina, Bernardini, Sergio, Minieri, Marilena, Pieri, Massimo, Giaroni, Cristina, Acquati, Francesco, Costantino, Lucy, Ferrara, Fulvio, Valli, Roberto, and Porta, Giovanni

Subjects
HOMEOBOX genes, NASAL mucosa, MAMMARY glands, GENE amplification, PITUITARY gland, GENES, TISSUES
Abstract

OTX homeobox genes have been extensively studied for their role in development, especially in neuroectoderm formation. Recently, their expression has also been reported in adult physiological and pathological tissues, including retina, mammary and pituitary glands, sinonasal mucosa, in several types of cancer, and in response to inflammatory, ischemic, and hypoxic stimuli. Reactivation of OTX genes in adult tissues supports the notion of the evolutionary amplification of functions of genes by varying their temporal expression, with the selection of homeobox genes from the "toolbox" to drive or contribute to different processes at different stages of life. OTX involvement in pathologies points toward these genes as potential diagnostic and/or prognostic markers as well as possible therapeutic targets. [ABSTRACT FROM AUTHOR]

Published
2023
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7. The miR-133a, TPM4 and TAp63γ Role in Myocyte Differentiation Microfilament Remodelling and Colon Cancer Progression

Author

Caporali, Sabrina, primary, Calabrese, Cosimo, additional, Minieri, Marilena, additional, Pieri, Massimo, additional, Tarantino, Umberto, additional, Marini, Mario, additional, D’Ottavio, Stefano, additional, Angeletti, Silvia, additional, Mauriello, Alessandro, additional, Cortese, Claudio, additional, Bernardini, Sergio, additional, and Terrinoni, Alessandro, additional

Published
2021
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8. Post Zygotic, Somatic, Deletion in KERATIN 1 V1 Domain Generates Structural Alteration of the K1/K10 Dimer, Producing a Monolateral Palmar Epidermolytic Nevus

Author

Caporali, Sabrina, primary, Didona, Biagio, additional, Paradisi, Mauro, additional, Mauriello, Alessandro, additional, Campione, Elena, additional, Falconi, Mattia, additional, Iacovelli, Federico, additional, Minieri, Marilena, additional, Pieri, Massimo, additional, Bernardini, Sergio, additional, and Terrinoni, Alessandro, additional

Published
2021
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9. Anti-Inflammatory and Proliferative Properties of Luteolin-7-O-Glucoside

Author

De Stefano, Alessandro, primary, Caporali, Sabrina, additional, Di Daniele, Nicola, additional, Rovella, Valentina, additional, Cardillo, Carmine, additional, Schinzari, Francesca, additional, Minieri, Marilena, additional, Pieri, Massimo, additional, Candi, Eleonora, additional, Bernardini, Sergio, additional, Tesauro, Manfredi, additional, and Terrinoni, Alessandro, additional

Published
2021
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10. Luteolin-7-O-β-d-Glucoside Inhibits Cellular Energy Production Interacting with HEK2 in Keratinocytes

Author

Palombo, Ramona, primary, Caporali, Sabrina, additional, Falconi, Mattia, additional, Iacovelli, Federico, additional, Morozzo Della Rocca, Blasco, additional, Lo Surdo, Alessandro, additional, Campione, Elena, additional, Candi, Eleonora, additional, Melino, Gerry, additional, Bernardini, Sergio, additional, and Terrinoni, Alessandro, additional

Published
2019
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13. Role of p63 isoform balance in recurrent nasal polyps

Author

Terrinoni, Alessandro, primary, Palombo, Ramona, additional, Pitolli, Consuelo, additional, Caporali, Sabrina, additional, Berardinis, Rita De, additional, Ciccarone, Silvana, additional, Lanzillotta, Alessia, additional, Mauramati, Simone, additional, Melino, Gerry, additional, Bernardini, Sergio, additional, and Bruno, Ernesto, additional

Published
2018
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14. The circulating miRNAs as diagnostic and prognostic markers.

Author

Terrinoni, Alessandro, Calabrese, Cosimo, Basso, Daniela, Aita, Ada, Caporali, Sabrina, Plebani, Mario, and Bernardini, Sergio

Subjects
HUMAN genome, MICRORNA, BIOLOGICAL tags, NON-coding RNA, LIPIDS
Abstract

A large portion of the human genome transcribes RNA sequences that do not code for any proteins. The first of these sequences was identified in 1993, and the best known noncoding RNAs are microRNA (miRNAs). It is now fully established that miRNAs regulate approximately 30% of the known genes that codify proteins. miRNAs are involved in several biological processes, like cell proliferation, differentiation, apoptosis and metastatization. These RNA products regulate gene expression at the post-transcriptional level, modulating or inhibiting protein expression by interacting with specific sequences of mRNAs. Mature miRNAs can be detected in blood plasma, serum and also in a wide variety of biological fluids. They can be found associated with proteins, lipids as well as enclosed in exosome vesicles. We know that circulating miRNAs (C-miRNAs) can regulate several key cellular processes in tissues different from the production site. C-miRNAs behave as endogenous mediators of RNA translation, and an extraordinary knowledge on their function has been obtained in the last years. They can be secreted in different tissue cells and associated with specific pathological conditions. Significant evidence indicates that the initiation and progression of several pathologies are "highlighted" by the presence of specific C-miRNAs, underlining their potential diagnostic relevance as clinical biomarkers. Here we review the current literature on the possible use of this new class of molecules as clinical biomarkers of diseases. [ABSTRACT FROM AUTHOR]

Published
2019
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