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17 results on '"Capra, Lucetta"'

1. Narrative review on the management of moderate-severe atopic dermatitis in pediatric age of the Italian Society of Pediatric Allergology and Immunology (SIAIP), of the Italian Society of Pediatric Dermatology (SIDerP) and of the Italian Society of Pediatrics (SIP)

Author

Galli, Elena, Fortina, Anna Belloni, Ricci, Giampaolo, Maiello, Nunzia, Neri, Iria, Baldo, Ermanno, Berti, Irene, Bonamonte, Domenico, Capra, Lucetta, Carboni, Elena, Carello, Rossella, Caroppo, Francesca, Cavagni, Giovanni, Chinellato, Iolanda, Cipriani, Francesca, Comberiati, Pasquale, Diociaiuti, Andrea, Di Lernia, Vito, Duse, Marzia, Filippeschi, Cesare, Giannetti, Arianna, Giovannini, Mattia, Licari, Amelia, Marseglia, Gian Luigi, Pace, Manuela, Patrizi, Annalisa, Pajno, Giovanni Battista, Peroni, Diego, Villani, Alberto, and Eichenfield, Lawrence

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Pediatric Research Initiative, Good Health and Well Being, Adolescent, Child, Dermatitis, Atopic, Dermatology, Humans, Hyperplasia, Pediatricians, Pediatrics, Atopic Dermatitis, Childhood, Position Paper, Management, Topical Therapies, New Drugs, Paediatrics and Reproductive Medicine, Paediatrics
Abstract

Currently, there are a few detailed guidelines on the overall management of children and adolescents with moderate-severe atopic dermatitis. AD ​​is a complex disease presenting with different clinical phenotypes, which require an individualized and multidisciplinary approach. Therefore, appropriate interaction between primary care pediatricians, pediatric allergists, and pediatric dermatologists is crucial to finding the best management strategy. In this manuscript, members of the Italian Society of Pediatric Allergology and Immunology (SIAIP), the Italian Society of Pediatric Dermatology (SIDerP), and the Italian Society of Pediatrics (SIP) with expertise in the management of moderate-severe atopic dermatitis have reviewed the latest scientific evidence in the field. This narrative review aims to define a pathway to appropriately managing children and adolescents with moderate-severe atopic dermatitis.

Published
2022

2. Consensus Conference on Clinical Management of pediatric Atopic Dermatitis

Author

Galli, Elena, Neri, Iria, Ricci, Giampaolo, Baldo, Ermanno, Barone, Maurizio, Belloni Fortina, Anna, Bernardini, Roberto, Berti, Irene, Caffarelli, Carlo, Calamelli, Elisabetta, Capra, Lucetta, Carello, Rossella, Cipriani, Francesca, Comberiati, Pasquale, Diociaiuti, Andrea, El Hachem, Maya, Fontana, Elena, Gruber, Michaela, Haddock, Ellen, Maiello, Nunzia, Meglio, Paolo, Patrizi, Annalisa, Peroni, Diego, Scarponi, Dorella, Wielander, Ingrid, and Eichenfield, Lawrence F

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Digestive Diseases, Child, Dermatitis, Atopic, Evidence-Based Medicine, Humans, Italy, Pediatrics, Paediatrics and Reproductive Medicine, Paediatrics
Abstract

The Italian Consensus Conference on clinical management of atopic dermatitis in children reflects the best and most recent scientific evidence, with the aim to provide specialists with a useful tool for managing this common, but complex clinical condition. Thanks to the contribution of experts in the field and members of the Italian Society of Pediatric Allergology and Immunology (SIAIP) and the Italian Society of Pediatric Dermatology (SIDerP), this Consensus statement integrates the basic principles of the most recent guidelines for the management of atopic dermatitis to facilitate a practical approach to the disease. The therapeutical approach should be adapted to the clinical severity and requires a tailored strategy to ensure good compliance by children and their parents. In this Consensus, levels and models of intervention are also enriched by the Italian experience to facilitate a practical approach to the disease.

Published
2016

8. Microbiota in Healthy Skin and in Atopic Eczema

Author

Baviera, Giuseppe, Leoni, Maria Chiara, Capra, Lucetta, Cipriani, Francesca, Longo, Giorgio, Maiello, Nunzia, Ricci, Giampaolo, and Galli, Elena

Subjects
integumentary system, Article Subject
Abstract

The Italian interest group (IG) on atopic eczema and urticaria is member of the Italian Society of Allergology and Immunology. The aim of our IG is to provide a platform for scientists, clinicians, and experts. In this review we discuss the role of skin microbiota not only in healthy skin but also in skin suffering from atopic dermatitis (AD). A Medline and Embase search was conducted for studies evaluating the role of skin microbiota. We examine microbiota composition and its development within days after birth; we describe the role of specific groups of microorganisms that colonize distinct anatomical niches and the biology and clinical relevance of antimicrobial peptides expressed in the skin. Specific AD disease states are characterized by concurrent and anticorrelated shifts in microbial diversity and proportion of Staphylococcus. These organisms may protect the host, defining them not as simple symbiotic microbes but rather as mutualistic microbes. These findings reveal links between microbial communities and inflammatory diseases such as AD and provide novel insights into global shifts of bacteria relevant to disease progression and treatment. This review also highlights recent observations on the importance of innate immune systems and the relationship with normal skin microflora for the maintenance of healthy skin.

Published
2014
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12. Clinical effects of a Long-term Educational Program for Children with Asthma – Aironet®. A 1-yr randomized controlled trial.

Author

Indinnimeo, Luciana, Bonci, Enea, Capra, Lucetta, La Grutta, Stefania, Monaco, Francesca, Paravati, Francesco, Passalacqua, Giovanni, Silvestre, Gaetano, and Duse, Marzia

Subjects
ASTHMA in children, ALLERGY in children, EDUCATIONAL programs, ADRENOCORTICAL hormones, STEROID hormones
Abstract

Educational self-management programs for children with asthma have now become a routine feature in the management of the disease, as international guidelines underline. We designed this trial to find out whether Aironet®, an educational program developed for children with asthma, influenced asthma severity and improved parents’ knowledge of the disease. In a multicenter, prospective, randomized controlled trial we enrolled 123 children, 72 boys, mean age 8.78 yr (±2.33 s.d.), with intermittent or mild persistent asthma. Participants were randomly assigned to an education group, who received Aironet® at baseline and 2 months later (60 children), or to a control group who did not (63 children). Follow-up lasted 12 months and included out-patient clinic visits and spirometry at 2, 4 and 12 months. At baseline and at 12 months follow-up, parents were questioned about their knowledge of asthma, and their children’s asthmatic attacks, use of systemic corticosteroids, family physician or hospital emergency room visits, hospitalizations and asthma-related school absences. Questionnaire replies at 12-month follow-up reported significantly fewer asthma attacks in patients who received the program than in those who did not (1.65 ± 1.21 vs. 2.34 ± 1.73; p < 0.05). For the subgroup of children who had ≥3 asthma attacks at baseline, parents’ knowledge improved significantly more in the educational group than in the control group. The out-patient educational program Aironet® reduces the number of asthma attacks in children with intermittent or mild persistent asthma and improves knowledge of the disease. [ABSTRACT FROM AUTHOR]

Published
2009
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13. Consensus Conference Italiana 'La gestione clinica della dermatite atopica in età pediatrica'

Author

Galli, E., Neri, I., Barone, M., Belloni Fortina, A., Bernardini, R., Berti, I., Boner, A., Caffarelli, C., Calamelli, E., Capra, L., Carello, R., Pasquale Comberiati, Diociaiuti, A., El Hachem, M., Fontana, E., Gruber, M., Maiello, N., Meglio, P., Patrizi, A., Diego Peroni, Ricci, G., Scarponi, D., Wielander, I., Baldo, E., Galli, Elena, Neri, Iria, Barone, Maurizio, Fortina, Anna Belloni, Bernardini, Roberto, Berti, Irene, Boner, Attilio, Caffarelli, Carlo, Calamelli, Elisabetta, Capra, Lucetta, Carello, Rossella, Comberiati, Pasquale, Diociaiuti, Andrea, Hachem, Maya El, Fontana, Elena, Gruber, Michaela, Maiello, Nunzia, Meglio, Paolo, Patrizi, Annalisa, Peroni, Diego, Ricci, Giampaolo, Scarponi, Dorella, Wielander, Ingrid, and Baldo, Ermanno.

Subjects
età pediatrica, Socio-culturale, dermatite atopica, NA, dermatite atopica, età pediatrica
Abstract

NA

Published
2015

14. Microbiota in healthy skin and in atopic eczema

Author

Elena Galli, Maria Chiara Leoni, Giuseppe Baviera, Nunzia Maiello, Giorgio Longo, Lucetta Capra, Giampaolo Ricci, Francesca Cipriani, Baviera, Giuseppe, Leoni, Maria Chiara, Capra, Lucetta, Cipriani, Francesca, Longo, Giorgio, Maiello, Nunzia, Ricci, Giampaolo, and Galli, Elena

Subjects
Allergy, Immunology and Microbiology (all), MEDLINE, Staphylococcus, Antimicrobial peptides, lcsh:Medicine, Disease, Review Article, Biology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Dermatitis, Atopic, Staphylococcu, Immunity, medicine, Humans, Clinical significance, Skin, Antimicrobial Cationic Peptide, Biochemistry, Genetics and Molecular Biology (all), Innate immune system, General Immunology and Microbiology, integumentary system, Medicine (all), Microbiota, lcsh:R, General Medicine, Atopic dermatitis, medicine.disease, Immunity, Innate, Immunology, Human, Antimicrobial Cationic Peptides
Abstract

The Italian interest group (IG) on atopic eczema and urticaria is member of the Italian Society of Allergology and Immunology. The aim of our IG is to provide a platform for scientists, clinicians, and experts. In this review we discuss the role of skin microbiota not only in healthy skin but also in skin suffering from atopic dermatitis (AD). A Medline and Embase search was conducted for studies evaluating the role of skin microbiota. We examine microbiota composition and its development within days after birth; we describe the role of specific groups of microorganisms that colonize distinct anatomical niches and the biology and clinical relevance of antimicrobial peptides expressed in the skin. Specific AD disease states are characterized by concurrent and anticorrelated shifts in microbial diversity and proportion ofStaphylococcus. These organisms may protect the host, defining them not as simple symbiotic microbes but rather as mutualistic microbes. These findings reveal links between microbial communities and inflammatory diseases such as AD and provide novel insights into global shifts of bacteria relevant to disease progression and treatment. This review also highlights recent observations on the importance of innate immune systems and the relationship with normal skin microflora for the maintenance of healthy skin.

Published
2014

15. Autoimmunity in atopic dermatitis: Biomarker or simply epiphenomenon?

Author

Elena Galli, Maria Chiara Leoni, Lucetta Capra, Francesca Cipriani, Giorgio Longo, Nunzia Maiello, Giuseppe Baviera, Giampaolo Ricci, Cipriani, Francesca, Ricci, Giampaolo, Leoni, Maria Chiara, Capra, Lucetta, Baviera, Giuseppe, Longo, Giorgio, Maiello, Nunzia, and Galli, Elena

Subjects
atopic dermatiti, medicine.medical_specialty, Epiphenomenon, Dermatology, Disease, Immunoglobulin E, medicine.disease_cause, Autoantigens, Autoimmunity, Dermatitis, Atopic, Pathogenesis, Humans, Medicine, Autoantibodies, Skin, biology, business.industry, Medicine (all), autoimmunity, self antigen, Autoantibody, General Medicine, Atopic dermatitis, Biomarker, medicine.disease, autoantibodie, autoantigen, body regions, Immunology, biology.protein, Biomarker (medicine), business, Biomarkers, Human
Abstract

The idea that a mechanism of autoimmunity could play a role in the pathogenesis of atopic dermatitis gained support from the observation that patients with atopic dermatitis display IgE reactivity to a variety of human protein antigens, several of which have been characterized at molecular level. A broad spectrum of at least 140 IgE-binding self-antigens associated with atopic dermatitis has been demonstrated; they might promote, perpetuate, or both, skin inflammation by binding IgE antibodies or activating specific T cells. Even if the presence of autoreactivity seems to be associated with the severity of the disease and may be used as a parameter reflecting chronic tissue damage, at the state of art the role of autoimmunity in atopic dermatitis is far from clear. Data from the literature show that the use of autoantibodies as biomarkers of atopic dermatitis are still limited by the evidence that the epiphenomenon of autoreactivity is detectable only in a percentage of patients and that the involved self-allergens often are not the same; further longitudinal case-control studies are needed to investigate and to clarify the pathogenethic role of autoimmunity in the course of atopic dermatitis. © 2014 Japanese Dermatological Association.

Published
2014

16. Consensus Conference on Clinical Management of pediatric Atopic Dermatitis

Author

E. Fontana, Anna Belloni Fortina, Lucetta Capra, Irene Berti, Francesca Cipriani, Rossella Carello, Ermanno Baldo, Maya El Hachem, Maurizio Barone, Dorella Scarponi, Andrea Diociaiuti, Giampaolo Ricci, Pasquale Comberiati, Ingrid Wielander, Annalisa Patrizi, Paolo Meglio, Iria Neri, Ellen S. Haddock, Lawrence F. Eichenfield, Nunzia Maiello, Elena Galli, Michaela Gruber, Elisabetta Calamelli, Diego Peroni, Roberto Bernardini, Carlo Caffarelli, Galli, Elena, Neri, Iria, Ricci, Giampaolo, Baldo, Ermanno, Barone, Maurizio, Belloni Fortina, Anna, Bernardini, Roberto, Berti, Irene, Caffarelli, Carlo, Calamelli, Elisabetta, Capra, Lucetta, Carello, Rossella, Cipriani, Francesca, Comberiati, Pasquale, Diociaiuti, Andrea, El Hachem, Maya, Fontana, Elena, Gruber, Michaela, Haddock, Ellen, Maiello, Nunzia, Meglio, Paolo, Patrizi, Annalisa, Peroni, Diego, Scarponi, Dorella, Wielander, Ingrid, and Eichenfield, Lawrence F.

Subjects
Pediatrics, medicine.medical_specialty, Consensus, MEDLINE, Dermatitis, Consensu, Review, Disease, Atopic, Dermatitis, Atopic, Scientific evidence, Paediatrics and Reproductive Medicine, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Intervention (counseling), Humans, Medicine, Clinical severity, Child, Atopic dermatitis, Pediatric, Evidence-Based Medicine, business.industry, Consensus conference, Evidence-based medicine, Perinatology and Child Health, Atopic dermatiti, medicine.disease, Childhood, Management, Italy, 030228 respiratory system, Family medicine, Pediatrics, Perinatology and Child Health, Digestive Diseases, business
Abstract

The Italian Consensus Conference on clinical management of atopic dermatitis in children reflects the best and most recent scientific evidence, with the aim to provide specialists with a useful tool for managing this common, but complex clinical condition. Thanks to the contribution of experts in the field and members of the Italian Society of Pediatric Allergology and Immunology (SIAIP) and the Italian Society of Pediatric Dermatology (SIDerP), this Consensus statement integrates the basic principles of the most recent guidelines for the management of atopic dermatitis to facilitate a practical approach to the disease. The therapeutical approach should be adapted to the clinical severity and requires a tailored strategy to ensure good compliance by children and their parents. In this Consensus, levels and models of intervention are also enriched by the Italian experience to facilitate a practical approach to the disease.

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17. Effectiveness of intranasal corticosteroids.

Author

Grzincich G, Capra L, Cammarata MG, Spaggiari C, and Pisi G

Subjects
Administration, Intranasal, Humans, Adrenal Cortex Hormones administration & dosage, Rhinitis, Allergic, Perennial drug therapy, Rhinitis, Allergic, Seasonal drug therapy
Abstract

Intranasal corticosteroids (IC) are most commonly prescribed to treat allergic rhinitis (perennial and seasonal). There are now many IC available to treat rhinitis, all effective on nasal obstruction, rhinorrhea, sneezing, itching and post-nasal drip. IC are superior to oral antihistamines for the relief of all nasal symptoms; however, antihistamines are first line therapy if allergic conjunctivitis coexists. At present the data do not support the use of IC in the management of otitis media with effusion (OME), nasal polyposis and sinusitis, but when topical IC are administered together with antibiotic therapy they facilitate a more rapid improvement of symptoms.

Published
2004

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