2,873 results on '"Capria, A"'
Search Results
2. Observation, Analysis and Evaluation of the Industrial Contribution to the Peer-Reviewed Public Access of the ESRF: A Pilot Study
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Zhang, Junhanlu, Capria, Ennio, Gutleber, Johannes, editor, and Charitos, Panagiotis, editor
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- 2025
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3. Hematopoietic stem cell transplantation for DLBCL: a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years
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Berning, Philipp, Fekom, Mathilde, Ngoya, Maud, Goldstone, Anthony H., Dreger, Peter, Montoto, Silvia, Finel, Hervé, Shumilov, Evgenii, Chevallier, Patrice, Blaise, Didier, Strüssmann, Tim, Carpenter, Ben, Forcade, Edouard, Castilla-Llorente, Cristina, Trneny, Marek, Ghesquieres, Hervé, Capria, Saveria, Thieblemont, Catherine, Blau, Igor Wolfgang, Meijer, Ellen, Broers, Annoek E. C., Huynh, Anne, Caillot, Denis, Rösler, Wolf, Nguyen Quoc, Stephanie, Bittenbring, Jörg, Nagler, Arnon, Galimard, Jacques-Emmanuel, Glass, Bertram, Sureda, Anna, and Schmitz, Norbert
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- 2024
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4. Hematopoietic stem cell transplantation for DLBCL: a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years
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Philipp Berning, Mathilde Fekom, Maud Ngoya, Anthony H. Goldstone, Peter Dreger, Silvia Montoto, Hervé Finel, Evgenii Shumilov, Patrice Chevallier, Didier Blaise, Tim Strüssmann, Ben Carpenter, Edouard Forcade, Cristina Castilla-Llorente, Marek Trneny, Hervé Ghesquieres, Saveria Capria, Catherine Thieblemont, Igor Wolfgang Blau, Ellen Meijer, Annoek E. C. Broers, Anne Huynh, Denis Caillot, Wolf Rösler, Stephanie Nguyen Quoc, Jörg Bittenbring, Arnon Nagler, Jacques-Emmanuel Galimard, Bertram Glass, Anna Sureda, and Norbert Schmitz
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Autologous(auto-) and allogeneic(allo-) hematopoietic stem cell transplantation (HSCT) are key treatments for relapsed/refractory diffuse large B-cell lymphoma (DLBCL), although their roles are challenged by CAR-T-cells and other immunotherapies. We examined the transplantation trends and outcomes for DLBCL patients undergoing auto-/allo-HSCT between 1990 and 2021 reported to EBMT. Over this period, 41,148 patients underwent auto-HSCT, peaking at 1911 cases in 2016, while allo-HSCT saw a maximum of 294 cases in 2018. The recent decline in transplants corresponds to increased CAR-T treatments (1117 cases in 2021). Median age for auto-HSCT rose from 42 (1990–1994) to 58 years (2015–2021), with peripheral blood becoming the primary stem cell source post-1994. Allo-HSCT median age increased from 36 (1990–1994) to 54 (2015–2021) years, with mobilized blood as the primary source post-1998 and reduced intensity conditioning post-2000. Unrelated and mismatched allo-HSCT accounted for 50% and 19% of allo-HSCT in 2015–2021. Three-year overall survival (OS) after auto-HSCT improved from 56% (1990–1994) to 70% (2015–2021), p 40,000 transplants, providing insights for evaluating emerging DLBCL therapies.
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- 2024
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5. Evolution of pits at the surface of 67P/Churyumov-Gerasimenko
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Benseguane, Selma, Guilbert-Lepoutre, Aurélie, Lasue, Jérémie, Besse, Sébastien, Leyrat, Cédric, Beth, Arnaud, Sitjà, Marc Costa, Grieger, Björn, and Capria, Maria Teresa
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The observation of pits at the surface of comets offers the opportunity to take a glimpse into the properties and the mechanisms that shape a nucleus through cometary activity. If the origin of these pits is still a matter of debate, multiple studies have recently suggested that known phase transitions alone could not have carved these morphological features on the surface of 67P/C-G. We want to understand how the progressive modification of 67P's surface due to cometary activity might have affected the characteristics of pits. In particular, we aim to understand whether signatures of the formation mechanism of these morphological features can still be identified. To quantify the amount of erosion sustained at the surface of 67P since it arrived on its currently observed orbit, we selected 380 facets of a medium-resolution shape model of the nucleus, sampling 30 pits across the surface. We computed the surface energy balance with a high temporal resolution, including shadowing and self-heating. We then applied a thermal evolution model to assess the amount of erosion sustained after ten orbital revolutions under current illumination conditions. We find that the maximum erosion sustained after ten orbital revolutions is on the order of 80 m, for facets located in the southern hemisphere. We thus confirm that progressive erosion cannot form pits and alcoves, as local erosion is much lower than their observed depth and diameter. We find that plateaus tend to erode more than bottoms, especially for the deepest depressions, and that some differential erosion can affect their morphology. As a general rule, our results suggest that sharp morphological features tend to be erased by progressive erosion. This study supports the assumption that deep circular pits, such as Seth1, are the least processed morphological features at the surface of 67P, or the best preserved since their formation.
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- 2022
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6. Neutral genetic diversity follows a latitudinal gradient in the endangered plant Arnica montana L.: a range-wide study
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Capria, Loris, Liepelt, Sascha, Eimert, Klaus, Leyer, Ilona, and Mosner, Eva
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- 2024
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7. On Selleri's 'Weak Relativity'
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Mamone-Capria, Marco
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General Relativity and Quantum Cosmology ,Physics - History and Philosophy of Physics - Abstract
F. Selleri's main arguments for the restoration of absolute simultaneity in physics are analysed and shown to be faulty. In particular both the classical Sagnac effect and the recent so-called linear Sagnac effect can be dealt with within special relativity in a natural way. The appeal to the conventionality of simultaneity thesis is also shown to be ineffectual. Other arguments, such as the two spaceships' argument and the block universe argument are briefly examined. Notwithstanding a negative overall assessment, the importance of keeping alive the research on the foundations of relativity is emphasized and Selleri's role in this undertaking appreciated., Comment: 27 pages, 8 figures
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- 2022
8. Impressive weight loss induced by a very low-calorie ketogenic diet in a morbidly complex obese patient with a recent episode of acute kidney injury and advanced chronic kidney disease: a case report
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Vincenzo Trapanese, Maria Chiara Pelle, Maria Capria, Nazareno Carullo, Clara Vatalaro, Francesca Cosentino, Melania Melina, Maria Resilde Natale, Federica Giofrè, and Franco Arturi
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Ketogenic diet ,chronic kidney disease ,obesity ,acute kidney injury ,case report ,Medicine - Abstract
The very low-calorie ketogenic diet (VLCKD), characterized by a marked energy restriction that induces rapid weight loss, has recently been proposed as a valid nutritional strategy for managing obesity. VLCKD is commonly considered dangerous for the kidneys due to the misconception that it is high in protein, beyond the risk of electrolyte imbalances and an increase in diuresis. We report a case of safe and effective weight loss induced by VLCKD in a 43-year-old Caucasian woman with a recent episode of acute kidney injury on advanced chronic kidney disease. Surprisingly, we observed that after the diet-induced weight loss, not only did renal function not worsen, but proteinuria also improved. The principal value of this case report is its singular demonstration of impressive weight loss induced by VLCKD in a complex obese patient that was apparently not accompanied by the development of serious adverse sequelae.
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- 2024
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9. Associations between e-cigarette marketing exposure and vaping nicotine and cannabis among U.S. adults, 2021
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Chen-Sankey, Julia, La Capria, Kathryn, Glasser, Allison, Padon, Alisa A., Moran, Meghan B., Wagoner, Kimberly G., Jackson, Kristina M., and Berg, Carla J.
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- 2024
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10. Effects of Mercury surface temperature on the sodium abundance in its exosphere
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Rognini, E., Mura, A., Capria, M. T., Milillo, A., Zinzi, A., and Galluzzi, V.
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Astrophysics - Earth and Planetary Astrophysics ,Physics - Geophysics - Abstract
The link between the surface temperature of Mercury and the exosphere sodium content has been investigated. Observations show that, along the orbit of Mercury, two maxima of total Na content are present: one at aphelion and one at perihelion. Previous models, based on a simple thermal map, were not able to reproduce the aphelion peak. Here we introduce a new thermophysical model giving soil temperatures as an input for the IAPS exospheric model already used in the past with the input of a simple thermal map. By comparing the reference model output with the new one, we show that such improved surface temperature map is crucial to explain the temporal variability of Sodium along the orbit.
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- 2022
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11. Fiori giapponesi - Esercizi superficiali
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Raffaele La Capria
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- 2024
12. La bellezza di Roma
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Raffaele La Capria
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- 2024
13. Identifying FUS amyotrophic lateral sclerosis disease signatures in patient dermal fibroblasts
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Kumbier, Karl, Roth, Maike, Li, Zizheng, Lazzari-Dean, Julia, Waters, Christopher, Hammerlindl, Sabrina, Rinaldi, Capria, Huang, Ping, Korobeynikov, Vladislav A., Phatnani, Hemali, Shneider, Neil, Jacobson, Matthew P., Wu, Lani F., and Altschuler, Steven J.
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- 2024
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14. The Comet Interceptor Mission
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Jones, Geraint H., Snodgrass, Colin, Tubiana, Cecilia, Küppers, Michael, Kawakita, Hideyo, Lara, Luisa M., Agarwal, Jessica, André, Nicolas, Attree, Nicholas, Auster, Uli, Bagnulo, Stefano, Bannister, Michele, Beth, Arnaud, Bowles, Neil, Coates, Andrew, Colangeli, Luigi, Corral van Damme, Carlos, Da Deppo, Vania, De Keyser, Johan, Della Corte, Vincenzo, Edberg, Niklas, El-Maarry, Mohamed Ramy, Faggi, Sara, Fulle, Marco, Funase, Ryu, Galand, Marina, Goetz, Charlotte, Groussin, Olivier, Guilbert-Lepoutre, Aurélie, Henri, Pierre, Kasahara, Satoshi, Kereszturi, Akos, Kidger, Mark, Knight, Matthew, Kokotanekova, Rosita, Kolmasova, Ivana, Kossacki, Konrad, Kührt, Ekkehard, Kwon, Yuna, La Forgia, Fiorangela, Levasseur-Regourd, Anny-Chantal, Lippi, Manuela, Longobardo, Andrea, Marschall, Raphael, Morawski, Marek, Muñoz, Olga, Näsilä, Antti, Nilsson, Hans, Opitom, Cyrielle, Pajusalu, Mihkel, Pommerol, Antoine, Prech, Lubomir, Rando, Nicola, Ratti, Francesco, Rothkaehl, Hanna, Rotundi, Alessandra, Rubin, Martin, Sakatani, Naoya, Sánchez, Joan Pau, Simon Wedlund, Cyril, Stankov, Anamarija, Thomas, Nicolas, Toth, Imre, Villanueva, Geronimo, Vincent, Jean-Baptiste, Volwerk, Martin, Wurz, Peter, Wielders, Arno, Yoshioka, Kazuo, Aleksiejuk, Konrad, Alvarez, Fernando, Amoros, Carine, Aslam, Shahid, Atamaniuk, Barbara, Baran, Jędrzej, Barciński, Tomasz, Beck, Thomas, Behnke, Thomas, Berglund, Martin, Bertini, Ivano, Bieda, Marcin, Binczyk, Piotr, Busch, Martin-Diego, Cacovean, Andrei, Capria, Maria Teresa, Carr, Chris, Castro Marín, José María, Ceriotti, Matteo, Chioetto, Paolo, Chuchra-Konrad, Agata, Cocola, Lorenzo, Colin, Fabrice, Crews, Chiaki, Cripps, Victoria, Cupido, Emanuele, Dassatti, Alberto, Davidsson, Björn J. R., De Roche, Thierry, Deca, Jan, Del Togno, Simone, Dhooghe, Frederik, Donaldson Hanna, Kerri, Eriksson, Anders, Fedorov, Andrey, Fernández-Valenzuela, Estela, Ferretti, Stefano, Floriot, Johan, Frassetto, Fabio, Fredriksson, Jesper, Garnier, Philippe, Gaweł, Dorota, Génot, Vincent, Gerber, Thomas, Glassmeier, Karl-Heinz, Granvik, Mikael, Grison, Benjamin, Gunell, Herbert, Hachemi, Tedjani, Hagen, Christian, Hajra, Rajkumar, Harada, Yuki, Hasiba, Johann, Haslebacher, Nico, Herranz De La Revilla, Miguel Luis, Hestroffer, Daniel, Hewagama, Tilak, Holt, Carrie, Hviid, Stubbe, Iakubivskyi, Iaroslav, Inno, Laura, Irwin, Patrick, Ivanovski, Stavro, Jansky, Jiri, Jernej, Irmgard, Jeszenszky, Harald, Jimenéz, Jaime, Jorda, Laurent, Kama, Mihkel, Kameda, Shingo, Kelley, Michael S. P., Klepacki, Kamil, Kohout, Tomáš, Kojima, Hirotsugu, Kowalski, Tomasz, Kuwabara, Masaki, Ladno, Michal, Laky, Gunter, Lammer, Helmut, Lan, Radek, Lavraud, Benoit, Lazzarin, Monica, Le Duff, Olivier, Lee, Qiu-Mei, Lesniak, Cezary, Lewis, Zoe, Lin, Zhong-Yi, Lister, Tim, Lowry, Stephen, Magnes, Werner, Markkanen, Johannes, Martinez Navajas, Ignacio, Martins, Zita, Matsuoka, Ayako, Matyjasiak, Barbara, Mazelle, Christian, Mazzotta Epifani, Elena, Meier, Mirko, Michaelis, Harald, Micheli, Marco, Migliorini, Alessandra, Millet, Aude-Lyse, Moreno, Fernando, Mottola, Stefano, Moutounaick, Bruno, Muinonen, Karri, Müller, Daniel R., Murakami, Go, Murata, Naofumi, Myszka, Kamil, Nakajima, Shintaro, Nemeth, Zoltan, Nikolajev, Artiom, Nordera, Simone, Ohlsson, Dan, Olesk, Aire, Ottacher, Harald, Ozaki, Naoya, Oziol, Christophe, Patel, Manish, Savio Paul, Aditya, Penttilä, Antti, Pernechele, Claudio, Peterson, Joakim, Petraglio, Enrico, Piccirillo, Alice Maria, Plaschke, Ferdinand, Polak, Szymon, Postberg, Frank, Proosa, Herman, Protopapa, Silvia, Puccio, Walter, Ranvier, Sylvain, Raymond, Sean, Richter, Ingo, Rieder, Martin, Rigamonti, Roberto, Ruiz Rodriguez, Irene, Santolik, Ondrej, Sasaki, Takahiro, Schrödter, Rolf, Shirley, Katherine, Slavinskis, Andris, Sodor, Balint, Soucek, Jan, Stephenson, Peter, Stöckli, Linus, Szewczyk, Paweł, Troznai, Gabor, Uhlir, Ludek, Usami, Naoto, Valavanoglou, Aris, Vaverka, Jakub, Wang, Wei, Wang, Xiao-Dong, Wattieaux, Gaëtan, Wieser, Martin, Wolf, Sebastian, Yano, Hajime, Yoshikawa, Ichiro, Zakharov, Vladimir, Zawistowski, Tomasz, Zuppella, Paola, Rinaldi, Giovanna, and Ji, Hantao
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- 2024
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15. IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA: PATHOPHYSIOLOGY, DIAGNOSIS AND OPEN ISSUES.
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Silvia Maria Trisolini, Alessandro Laganà, and Saveria Capria
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rituximab ,Caplacizumab ,thrombotic thrombocytopenic purpura ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Immune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, thrombocytopenia, and ischemic end organ injury due to microvascular platelet-rich thrombi. iTTP pathophysiology is based on a severe ADAMTS13 deficiency, the specific von Willebrand factor (vWF)-cleaving protease, due to anti-ADAMTS13 autoantibodies. Early diagnosis and treatment reduce the mortality. Front-line therapy includes daily plasma exchange (PEX) with fresh frozen plasma replacement and immunosuppression with corticosteroids. Caplacizumab is recently added to the front-line therapy. Caplacizumab is a nanobody that binds to the A1 domain of vWF, blocking the interaction of ultra-large vWF multimers with the platelet, and thereby preventing the formation of platelet-rich thrombi. Caplacizumab reduces mortality due to ischemic events, refractoriness and exacerbations after PEX discontinuation. Until now, the criteria for response to treatment mainly took into account the normalization of platelet count and discontinuation of PEX, now with the use of caplacizumab, leading to rapid normalization of platelet count, it has been necessary to redefine the response criteria, taking into account also the underlying autoimmune disease. Monitoring of ADAMTS13 activity is important to identify cases with low value of activity (
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- 2024
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16. The therapeutic effects of gingival mesenchymal stem cells and their exosomes in a chimeric model of rheumatoid arthritis
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Shane Bruckner, Vittoria M. Capria, Braden Zeno, Binnaz Leblebicioglu, Kanu Goyal, William K. Vasileff, Hisham Awan, William L. Willis, Latha P. Ganesan, and Wael N. Jarjour
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Rheumatoid arthritis ,Synovial fibroblasts ,Gingival-derived mesenchymal stem cells ,Exosomes ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Rheumatoid arthritis is a chronic systemic autoimmune disease that involves transformation of the lining of synovial joints into an invasive and destructive tissue. Synovial fibroblasts become transformed, invading and destroying the bone and cartilage of the affected joint(s). Due to the significant role these cells play in the progression of the disease process, developing a therapeutic strategy to target and inhibit their invasive destructive nature could help patients who are afflicted with this debilitating disease. Gingival-derived mesenchymal stem cells are known to possess immunomodulatory properties and have been studied extensively as potential cell-based therapeutics for several autoimmune disorders. Methods A chimeric human/mouse model of synovitis was created by surgically implanting SCID mice with a piece of human articular cartilage surrounded by RASF. Mice were injected once with either GMSC or GMSCExo at 5–7 days post-implantation. Histology and IHC were used to assess RASF invasion of the cartilage. Flow cytometry was used to understand the homing ability of GMSC in vivo and the incidence of apoptosis of RASF in vitro. Results We demonstrate that both GMSC and GMSCExo are potent inhibitors of the deleterious effects of RASF. Both treatments were effective in inhibiting the invasive destructive properties of RASF as well as the potential for these cells to migrate to secondary locations and attack the cartilage. GMSC home to the site of the implant and induce programmed cell death of the RASF. Conclusions Our results indicate that both GMSC and GMSCExo can block the pathological effects of RASF in this chimeric model of RA. A single dose of either GMSC or GMSCExo can inhibit the deleterious effects of RASF. These treatments can also block the invasive migration of the RASF, suggesting that they can inhibit the spread of RA to other joints. Because the gingival tissue is harvested with little difficulty, relatively small amounts of tissue are required to expand the cells, the simple in vitro expansion process, and the increasing technological advances in the production of therapeutic exosomes, we believe that GMSCExo are excellent candidates as a potential therapeutic for RA.
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- 2023
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17. Impact of gemtuzumab ozogamicin consolidation on hematopoietic stem cells (HSCs) mobilization in AML: analysis of 20 patients
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Perrone, Salvatore, Capria, Saveria, Bernardi, Massimo, Marchesi, Francesco, Ortu La Barbera, Elettra, Trisolini, Silvia Maria, Minotti, Clara, Shafii Bafti, Mahnaz, Scerpa, Maria Cristina, Mulé, Antonino, Ciceri, Fabio, Martelli, Maurizio, and Cimino, Giuseppe
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- 2023
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18. Semaglutide and kidney function: friends or enemies?
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Federica Giofrè, Vincenzo Trapanese, Maria Resilde Natale, Clara Vatalaro, Francesca Cosentino, Melania Melina, Maria Chiara Pelle, Nazareno Carullo, Maria Capria, and Franco Arturi
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Semaglutide ,glucagon-like peptide-1 receptor agonist ,type 2 diabetes ,acute kidney injury ,obesity ,Medicine - Abstract
Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RAs) approved for the treatment of type 2 diabetes mellitus (T2DM) and chronic weight management in obesity. GLP-1RAs are being investigated to slow the decline of kidney function in type 2 diabetics with chronic kidney disease. These agents prevent renal complications and have proven beneficial effects on cardiac outcomes. We describe a rare case of semaglutide-induced acute kidney injury (AKI) in a young woman with obesity, T2DM, hypertensive cardiomyopathy, and no pre-existing chronic kidney disease (CKD). This case is relevant as GLP1-RAs is used frequently in patients with and without kidney disease. Currently, only 3 cases of AKI ascribed to semaglutide of which only 1 without CKD have been described. Only in this case, kidney function improves after semaglutide discontinuation. However, because GLP1-RAs will be prescribed more and more frequently, we sought to highlight this possible, serious adverse effect of semaglutide.
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- 2024
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19. Exocomets from a Solar System Perspective
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Strøm, Paul A., Bodewits, Dennis, Knight, Matthew M., Kiefer, Flavien, Jones, Geraint H., Kral, Quentin, Matrà, Luca, Bodman, Eva, Capria, Maria Teresa, Cleeves, Ilsedore, Fitzsimmons, Alan, Haghighipour, Nader, Harrison, John H. D., Iglesias, Daniela, Kama, Mihkel, Linnartz, Harold, Majumdar, Liton, de Mooij, Ernst J. W., Milam, Stefanie N., Opitom, Cyrielle, Rebollido, Isabel, Rogers, Laura K., Snodgrass, Colin, Sousa-Silva, Clara, Xu, Siyi, Lin, Zhong-Yi, and Zieba, Sebastian
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Exocomets are small bodies releasing gas and dust which orbit stars other than the Sun. Their existence was first inferred from the detection of variable absorption features in stellar spectra in the late 1980s using spectroscopy. More recently, they have been detected through photometric transits from space, and through far-IR/mm gas emission within debris disks. As (exo)comets are considered to contain the most pristine material accessible in stellar systems, they hold the potential to give us information about early stage formation and evolution conditions of extra Solar Systems. In the Solar System, comets carry the physical and chemical memory of the protoplanetary disk environment where they formed, providing relevant information on processes in the primordial solar nebula. The aim of this paper is to compare essential compositional properties between Solar System comets and exocomets. The paper aims to highlight commonalities and to discuss differences which may aid the communication between the involved research communities and perhaps also avoid misconceptions. Exocomets likely vary in their composition depending on their formation environment like Solar System comets do, and since exocomets are not resolved spatially, they pose a challenge when comparing them to high fidelity observations of Solar System comets. Observations of gas around main sequence stars, spectroscopic observations of "polluted" white dwarf atmospheres and spectroscopic observations of transiting exocomets suggest that exocomets may show compositional similarities with Solar System comets. The recent interstellar visitor 2I/Borisov showed gas, dust and nuclear properties similar to that of Solar System comets. This raises the tantalising prospect that observations of interstellar comets may help bridge the fields of exocomet and Solar System comets., Comment: 25 pages, 3 figures. To be published in PASP. This paper is the product of a workshop at the Lorentz Centre in Leiden, the Netherlands
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- 2020
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20. The therapeutic effects of gingival mesenchymal stem cells and their exosomes in a chimeric model of rheumatoid arthritis
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Bruckner, Shane, Capria, Vittoria M., Zeno, Braden, Leblebicioglu, Binnaz, Goyal, Kanu, Vasileff, William K., Awan, Hisham, Willis, William L., Ganesan, Latha P., and Jarjour, Wael N.
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- 2023
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21. True vs. false immune-mediated thrombotic thrombocytopenic purpura exacerbations: a clinical case in the caplacizumab era
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Laganà, Alessandro, Trisolini, Silvia Maria, Maglione, Raffaele, Mahnaz, Shafii Bafti, Imperatore, Stefano, Vitullo, Diana, and Capria, Saveria
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- 2024
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22. Pediatric Autologous Hematopoietic Stem Cell Transplantation: Safety, Efficacy, and Patient Outcomes. Literature Review
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Testi AM, Moleti ML, Angi A, Bianchi S, Barberi W, and Capria S
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autologous stem cell transplant ,pediatric age ,acute leukemia ,chronic myeloid leukemia ,hodgkin lymphoma ,non-hodgkin lymphoma ,Pediatrics ,RJ1-570 - Abstract
Anna Maria Testi, Maria Luisa Moleti, Alessia Angi, Simona Bianchi, Walter Barberi, Saveria Capria Department of Translational and Precision Medicine, Sapienza, University of Rome, Rome, ItalyCorrespondence: Anna Maria Testi, Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Via Benevento 6, Rome, 00161, Italy, Tel +39-06-49974731, Fax +39-06-44241984, Email testi@bce.uniroma1.itAbstract: Autologous stem cell transplantation (auto-HSCT) is a part of the therapeutic strategy for various oncohematological diseases. The auto-HSCT procedure enables hematological recovery after high-dose chemotherapy, otherwise not tolerable, by the infusion of autologous hematopoietic stem cells. Unlike allogeneic transplant (allo-HSCT), auto-HSCT has the advantage of lacking acute-graft-versus-host disease (GVHD) and prolonged immunosuppression, however, these advantages are counterbalanced by the absence of graft-versus-leukemia. Moreover, in hematological malignancies, the autologous hematopoietic stem cell source may be contaminated by neoplastic cells, leading to disease reappearance. In recent years, allogeneic transplant-related mortality (TRM) has progressively decreased, almost approaching auto-TRM, and many alternative donor sources are available for the majority of patients eligible for transplant procedures. In adults, the role of auto-HSCT compared to conventional chemotherapy (CT) in hematological malignancies has been well defined in many extended randomized trials; however, such trials are lacking in pediatric cohorts. Therefore, the role of auto-HSCT in pediatric oncohematology is limited, in both first- and second-line therapies and still remains to be defined. Nowadays, the accurate stratification in risk groups, according to the biological characteristics of the tumors and therapy response, and the introduction of new biological therapies, have to be taken into account in order to assign auto-HSCT a precise role in the therapeutic strategies, also considering that in the developmental age, auto-HSCT has a clear advantage over allo-HSCT, in terms of late sequelae, such as organ damage and second neoplasms. The purpose of this review is to report the results obtained with auto-HSCT in the different pediatric oncohematological diseases, focusing on the most significant literature data in the context of the various diseases and discussing this data in the light of the current therapeutic landscape.Keywords: autologous stem cell transplant, pediatric age, acute leukemia, chronic myeloid leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma
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- 2023
23. A new X-ray beam induced current setup, coupled with X-ray diffraction imaging, for diamonds and semiconductors characterization by synchrotron techniques at ESRF
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Lafont, F., Baruchel, J., Bousquet, J., Capria, E., Celestre, R., Cotte, M., Dauvergne, D., Everaere, P., Gallin-Martel, M.L., Hoarau, C., Ibourk, O., Letellier, J., Molle, R., Muraz, J.-F., Nusimovici, D.Z., Reynaud, M., and Tran-Caliste, T.N.
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- 2023
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24. SDR-based passive radar technology
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Capria, Amerigo, primary, Saverino, Anna Lisa, additional, Giusti, Elisa, additional, and Martorella, Marco, additional
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- 2023
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25. Materials characterisation and software tools as key enablers in Industry 5.0 and wider acceptance of new methods and products
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Konstantopoulos, Georgios, Charitidis, Costas A., Bañares, Miguel A., Portela, Raquel, Zangenberg, Nikolaj, Capria, Ennio, Sebastiani, Marco, Goldbeck, Gerhard, Koumoulos, Elias, Boskovic, Bojan, Diplas, Spyros, Konchakova, Natalia, Todorov, Ilian, Dykeman, Donna, Avataneo, Silvia Giovanna, Falzetti, Marco, Diz, Enrique Lozano, Reinosa, Julian J., Burov, Ekaterina, Škrelić, Dejan, Jeliazkova, Nina, Barton, Bastian, Masotti, Giovanni, Tamarozzi, Tommaso, and Alcón, Iván Moya
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- 2023
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26. Virtual European Solar & Planetary Access (VESPA): a Planetary Science Virtual Observatory cornerstone
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Erard, S., Cecconi, B., Sidaner, P. Le, Chauvin, C., Rossi, A. P., Minin, M., Capria, T., Ivanovski, S., Schmitt, B., Genot, V., Andre, N., Marmo, C., Vandaele, A. C., Trompet, L., Scherf, M., Hueso, R., Maattanen, A., Carry, B., Achilleos, N., Soucek, J., Pisa, D., Benson, K., Fernique, P., and Millour, E.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
The Europlanet-2020 programme, which ended on Aug 31st, 2019, included an activity called VESPA (Virtual European Solar and Planetary Access), which focused on adapting Virtual Observatory (VO) techniques to handle Planetary Science data. This paper describes some aspects of VESPA at the end of this 4-years development phase and at the onset of the newly selected Europlanet-2024 programme starting in 2020. The main objectives of VESPA are to facilitate searches both in big archives and in small databases, to enable data analysis by providing simple data access and online visualization functions, and to allow research teams to publish derived data in an interoperable environment as easily as possible. VESPA encompasses a wide scope, including surfaces, atmospheres, magnetospheres and planetary plasmas, small bodies, helio-physics, exoplanets, and spectroscopy in solid phase. This system relies in particular on standards and tools developed for the Astronomy VO (IVOA) and extends them where required to handle specificities of Solar System studies. It also aims at making the VO compatible with tools and protocols developed in different contexts, for instance GIS for planetary surfaces, or time series tools for plasma-related measurements. An essential part of the activity is to publish a significant amount of high-quality data in this system, with a focus on derived products resulting from data analysis or simulations., Comment: Submitted to Data Science Journal
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- 2019
27. Diurnal variation of dust and gas production in comet 67P/Churyumov-Gerasimenko at the inbound equinox as seen by OSIRIS and VIRTIS-M on board Rosetta
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Tubiana, C., Rinaldi, G., Güttler, C., Snodgrass, C., Shi, X., Hu, X., Marschall, R., Fulle, M., Bockelée-Morvan, D., Naletto, G., Capaccioni, F., Sierks, H., Arnold, G., Barucci, M. A., Bertaux, J. -L., Bertini, I., Bodewits, D., Capria, M. T., Ciarniello, M., Cremonese, G., Crovisier, J., Da Deppo, V., Debei, S., De Cecco, M., Deller, J., De Sanctis, M. C., Davidsson, B., Doose, L., Erard, S., Filacchione, G., Fink, U., Formisano, M., Fornasier, S., Gutiérrez, P. J., Ip, W. -H., Ivanovski, S., Kappel, D., Keller, H. U., Kolokolova, L., Koschny, D., Krueger, H., La Forgia, F., Lamy, P. L., Lara, L. M., Lazzarin, M., Levasseur-Regourd, A. C., Lin, Z. -Y., Longobardo, A., López-Moreno, J. J., Marzari, F., Migliorini, A., Mottola, S., Rodrigo, R., Taylor, F., Toth, I., and Zakharov, V.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
On 27 Apr 2015, when 67P/C-G was at 1.76 au from the Sun and moving towards perihelion, the OSIRIS and VIRTIS-M instruments on Rosetta observed the evolving dust and gas coma during a complete rotation of the comet. We aim to characterize the dust, H2O and CO2 gas spatial distribution in the inner coma. To do this we performed a quantitative analysis of the release of dust and gas and compared the observed H2O production rate with the one calculated using a thermo-physical model. For this study we selected OSIRIS WAC images at 612 nm (dust) and VIRTIS-M image cubes at 612 nm, 2700 nm (H2O) and 4200 nm (CO2). We measured the average signal in a circular annulus, to study spatial variation around the comet, and in a sector of the annulus, to study temporal variation in the sunward direction with comet rotation, both at a fixed distance of 3.1 km from the comet centre. The spatial correlation between dust and water, both coming from the sun-lit side of the comet, shows that water is the main driver of dust activity in this time period. The spatial distribution of CO2 is not correlated with water and dust. There is no strong temporal correlation between the dust brightness and water production rate as the comet rotates. The dust brightness shows a peak at 0deg sub-solar longitude, which is not pronounced in the water production. At the same epoch, there is also a maximum in CO2 production. An excess of measured water production, with respect to the value calculated using a simple thermo-physical model, is observed when the head lobe and regions of the Southern hemisphere with strong seasonal variations are illuminated. A drastic decrease in dust production, when the water production (both measured and from the model) displays a maximum, happens when typical Northern consolidated regions are illuminated and the Southern hemisphere regions with strong seasonal variations are instead in shadow., Comment: 15 pages, accepted for publication in A&A
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- 2019
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28. VIRTIS-H observations of comet 67P's dust coma: spectral properties and color temperature variability with phase and elevation
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Bockelée-Morvan, D., Leyrat, C., Erard, S., Andrieu, F., Capaccioni, F., Filacchione, G., Hasselmann, P. H., Crovisier, J., Drossart, P., Arnold, G., Ciarniello, M., Kappel, D., Longobardo, A., Capria, M. -T., De Sanctis, M. C., Rinaldi, G., and Taylor, F.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We analyze 2-5 micrometre spectroscopic observations of the dust coma of comet 67P/Churyumov-Gerasimenko obtained with the VIRTIS-H instrument onboard Rosetta from 3 June to 29 October 2015 at heliocentric distances r_h = 1.24-1.55 AU. The 2-2.5 micrometre color, bolometric albedo, and color temperature are measured using spectral fitting. Data obtained at alpha = 90{\deg} solar phase angle show an increase of the bolometric albedo (0.05 to 0.14) with increasing altitude (0.5 to 8 km), accompanied by a possible marginal decrease of the color and color temperature. Possible explanations include the presence in the inner coma of dark particles on ballistic trajectories, and radial changes in particle composition. In the phase angle range 50-120{\deg}, phase reddening is significant (0.031 %/100 nm/{\deg}), for a mean color of 2 %/100 nm at alpha = 90{\deg}, that can be related to the roughness of the dust particles. Moreover, a decrease of the color temperature with decreasing phase angle is also observed at a rate of ~ 0.3 K/{\deg}, consistent with the presence of large porous particles, with low thermal inertia, and showing a significant day-to-night temperature contrast. Comparing data acquired at fixed phase angle (alpha = 90{\deg}), a 20% increase of the bolometric albedo is observed near perihelion. Heliocentric variations of the dust color are not significant in the analyzed time period. Measured color temperatures are varying from 260 to 320 K, and follow a r^0.6 variation in the r_h = 1.24-1.5 AU range, close to the expected r_h^0.5 value., Comment: 13 pages, 11 figures. Accepted for publication in Astronomy & Astrophysics
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- 2019
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29. Benefits and Safety of Empiric Antibiotic Treatment Active Against KPC-K. pneumoniae in Febrile Neutropenic Patients with Acute Leukemia Who are Colonized with KPC-K. pneumoniae. A 7-Years Retrospective Observational Cohort Study
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Micozzi A, Minotti C, Capria S, Cartoni C, Trisolini SM, Assanto GM, Barberi W, Moleti ML, Santilli S, Martelli M, and Gentile G
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ceftazidime-avibactam ,colistin ,haematological malignancies ,kpc-k.pneumoniae-bsi mortality rate ,Infectious and parasitic diseases ,RC109-216 - Abstract
Alessandra Micozzi,1 Clara Minotti,2 Saveria Capria,2 Claudio Cartoni,2 Silvia Maria Trisolini,2 Giovanni Manfredi Assanto,1 Walter Barberi,2 Maria Luisa Moleti,2 Stefania Santilli,3 Maurizio Martelli,1 Giuseppe Gentile1 1Haematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; 2Department of Haematology, Oncology and Dermatology, Azienda Policlinico Umberto I, Rome, Italy; 3Department of Diagnostics, Azienda Policlinico Umberto I, Rome, ItalyCorrespondence: Alessandra Micozzi, Haematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Via Benevento 6, Rome, 00161, Italy, Tel +39 6 857951, Fax +39 6 44241984, Email alessandra.micozzi@uniroma1.itPurpose: To evaluate the benefits and safety of the empiric antibiotic treatment (EAT) active against KPC-K. pneumoniae in febrile neutropenic patients with acute leukaemia (AL) who are colonised by KPC-K. pneumoniae.Patients and Methods: A 7-year (2013– 2019) retrospective observational cohort study was conducted at the Haematology, Sapienza Rome University (Italy) on 94 febrile neutropenia episodes (FNE) in AL patients KPC-K. pneumoniae carriers treated with active EAT.Results: Eighty-two (87%) FNE were empirically treated with antibiotic combinations [38 colistin-based and 44 ceftazidime-avibactam (CAZAVI)-based], 12 with CAZAVI monotherapy. Successful outcomes were observed in 88/94 (94%) FNE, 46/49 (94%) microbiologically documented infections, and 24/27 (89%) gram-negative bloodstream infections (GNB-BSI). Mortality due to infective causes was 4.2% (2.1% within 1 week). KPC-K. pneumoniae infections caused 28/94 FNE (30%) and KPC-K. pneumoniae-BSI was documented in 22 FNE (23.4%) (85% of GNB-BSI), in all cases patients received active EAT, and 21 survived. KPC-K.pneumoniae-BSI mortality rate was 4.5%. CAZAVI-based EAT showed better results than colistin-based EAT (55/56 vs 33/38, p = 0.037), overall and without EAT modification (41/56 vs 20/38, p = 0.02). Empirical combinations including CAZAVI were successful in 98% of cases (43/44 vs 33/38 for colistin-based EAT, p = 0.01), without modifications in 82% (36/44 vs 20/28, p = 0.02). All deaths occurred in patients treated with colistin-based EAT (4/38 vs 0/56, p = 0.02). CAZAVI-containing EAT was the only independent factor for an overall successful response (HR 0.058, CI 0.013– 1.072, p = 0.058). Nephrotoxicity occurred in 3(8%) patients undergoing colistin-based EAT (none in those undergoing CAZAVI-based EAT, p = 0.02).Conclusion: KPC-K. pneumoniae infections are frequent in colonised AL patients with FNE. EAT with active antibiotics, mainly CAZAVI-based combinations, was effective, safe, and associated with low overall and KPC-K. pneumoniae-BSI-related mortality.Keywords: ceftazidime-avibactam, colistin, haematological malignancies, KPC-K. pneumoniae-BSI mortality rate
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- 2023
30. Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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Rinaldi, Capria, Waters, Christopher S., Li, Zizheng, Kumbier, Karl, Rao, Lee, Nichols, R. Jeremy, Jacobson, Matthew P., Wu, Lani F., and Altschuler, Steven J.
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- 2023
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31. Nutrition intake in critically ill patients with coronavirus disease (COVID-19): A nationwide, multicentre, observational study in Argentina
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Chapela, Sebastián Pablo, Manzanares, William, Quesada, Eliana, Reberendo, María Jimena, Baccaro, Fernando, Aversa, Irina, Kecskes, Claudia Elisabeth, Magnifico, Lorena, Gonzalez, Victoria, Bolzicco, Daniela, Baraglia, Nancy, Navarrete, Priscila, Manrique, Ezequiel, Cascaron, María Fernanda, Dietrich, Ailen, Asparch, Jesica, Peralta, Leticia Betiana, Galletti, Cayetano, Capria, María Laura, Lombi, Yamila, Rodriguez, Marian Cecilia, Luna, Camila Ester, and Martinuzzi, Andrés Luciano Nicolas
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- 2023
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32. Autologous stem cell transplantation in favorable-risk acute myeloid leukemia: single-center experience and current challenges
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Capria, Saveria, Trisolini, Silvia Maria, Diverio, Daniela, Minotti, Clara, Breccia, Massimo, Cartoni, Claudio, Carmini, Daniela, Gozzer, Maria, La Rocca, Ursula, Shafii Bafti, Mahnaz, and Martelli, Maurizio
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- 2022
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33. The enabling power of international cooperation
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Perino, Maria Antonietta, primary, Ammannito, Eleonora, additional, Arrigo, Gabriella, additional, Capria, Maria Teresa, additional, Foing, Bernard, additional, Green, James, additional, Li, Ming, additional, Kim, Jyeong Ja, additional, Madi, Mohammad, additional, Onoda, Masami, additional, Toukaku, Yoshio, additional, Dehant, Véronique, additional, Blanc, Michel, additional, Rauer, Heike, additional, Bousquet, Pierre, additional, Lasue, Jérémie, additional, Grande, Manuel, additional, Guo, Linli, additional, Hutzler, Aurore, additional, and Lewis, Jonathan, additional
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- 2023
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34. Contributors
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Alves, Jorge, primary, Ammannito, Eleonora, additional, André, Nicolas, additional, Arrigo, Gabriella, additional, Asmar, Sami, additional, Atkinson, David, additional, Autino, Adriano, additional, Beck, Pierre, additional, Berger, Gilles, additional, Blanc, Michel, additional, Bolton, Scott, additional, Bourdon, Anne, additional, Bousquet, Pierre, additional, Bunce, Emma, additional, Capria, Maria Teresa, additional, Chabert, Pascal, additional, Charnoz, Sébastien, additional, Chide, Baptiste, additional, Chien, Steve, additional, Cinelli, Ilaria, additional, Day, John, additional, Dehant, Véronique, additional, Demory, Brice, additional, Domagal-Goldman, Shawn, additional, Dorn, Caroline, additional, Fairén, Alberto G., additional, Filice, Valerio, additional, Fletcher, Leigh N., additional, Foing, Bernard, additional, Forget, François, additional, Freeman, Anthony, additional, Gaudi, B. Scott, additional, Genova, Antonio, additional, Grande, Manuel, additional, Green, James, additional, Griton, Léa, additional, Guo, Linli, additional, Hammel, Heidi, additional, Heinicke, Christiane, additional, Helled, Ravit, additional, Heng, Kevin, additional, Herique, Alain, additional, Höning, Dennis, additional, Hook, Joshua Vander, additional, Hutzler, Aurore, additional, Imamura, Takeshi, additional, Jackman, Caitriona, additional, Kaspi, Yohai, additional, Kim, Jyeong Ja, additional, Kitzman, Daniel, additional, Kofman, Wlodek, additional, Kokubo, Eiichiro, additional, Korablev, Oleg, additional, Lasue, Jérémie, additional, Lazio, Joseph, additional, Leconte, Jérémy, additional, Lellouch, Emmanuel, additional, Le Sergeant d'Hendecourt, Louis, additional, Lewis, Jonathan, additional, Li, Ming, additional, Mackwell, Steve, additional, Madi, Mohammad, additional, Makaya, Advenit, additional, Mangold, Nicolas, additional, Marty, Bernard, additional, Maurice, Sylvestre, additional, McNutt, Ralph, additional, Michel, Patrick, additional, Morbidelli, Alessandro, additional, Mordasini, Christoph, additional, Mousis, Olivier, additional, Nesvorny, David, additional, Noack, Lena, additional, Onoda, Masami, additional, Opher, Merav, additional, Ori, Gian Gabriele, additional, Owen, James, additional, Paranicas, Chris, additional, Parro, Victor, additional, Perino, Maria Antonietta, additional, Plainaki, Christina, additional, Preston, Robert, additional, Prieto-Ballesteros, Olga, additional, Qin, Liping, additional, Quanz, Sascha, additional, Rauer, Heike, additional, Rodriguez-Manfredi, Jose A., additional, Schmidt, Juergen, additional, Senske, Dave, additional, Snellen, Ignas, additional, Soderlund, Krista M., additional, Sotin, Christophe, additional, Spilker, Linda, additional, Spohn, Tilman, additional, Stephenson, Keith, additional, Sterken, Veerle J., additional, Testi, Leonardo, additional, Tosi, Nicola, additional, Toukaku, Yoshio, additional, Udry, Stéphane, additional, Vandaele, Ann C., additional, Vazan, Allona, additional, Venturini, Julia, additional, Vernazza, Pierre, additional, Waite, J. Hunter, additional, Wambsganss, Joachim, additional, Wedler, Armin, additional, Westall, Frances, additional, Zarka, Philippe, additional, Zine, Sonia, additional, and Zong, Qiugang, additional
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- 2023
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35. Introduction to the “Planetary Exploration, Horizon 2061” foresight exercise
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Blanc, Michel, primary, Lewis, Jonathan, additional, Bousquet, Pierre, additional, Dehant, Véronique, additional, Foing, Bernard, additional, Grande, Manuel, additional, Guo, Linli, additional, Hutzler, Aurore, additional, Lasue, Jérémie, additional, Perino, Maria Antonietta, additional, Rauer, Heike, additional, Ammannito, Eleonora, additional, and Capria, Maria Teresa, additional
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- 2023
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36. Un giorno d'impazienza
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Raffaele La Capria
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- 2023
37. Dalla parte di Cassandra
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Carolina Capria
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- 2023
38. Quantification of particle number concentration in liposomal suspensions by Laser Transmission Spectroscopy (LTS)
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Sennato, Simona, Sarra, Angelo, Capria, Carlo Panella La, Bombelli, Cecilia, Donati, Enrica, Postorino, Paolo, and Bordi, Federico
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- 2023
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39. The SSDC contribution to the improvement of knowledge by means of 3D data projections of minor bodies
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Zinzi, Angelo, Ciarniello, Mauro, Della Corte, Vincenzo, Ivanovski, Stavro, Longobardo, Andrea, Migliorini, Alessandra, Capria, Maria Teresa, Palomba, Ernesto, and Rotundi, Alessandra
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The latest developments of planetary exploration missions devoted to minor bodies required new solutions to correctly visualize and analyse data acquired over irregularly shaped bodies. ASI Space Science Data Center (SSDC-ASI, formerly ASDC-ASI Science Data Center) worked on this task since early 2013, when started developing the web tool MATISSE (Multi-purpose Advanced Tool for the Instruments of the Solar System Exploration) mainly focused on the Rosetta/ESA space mission data. In order to visualize very high-resolution shape models, MATISSE uses a Python module (vtpMaker), which can also be launched as a stand-alone command-line software. MATISSE and vtpMaker are part of the SSDC contribution to the new challenges imposed by the "orbital exploration" of minor bodies: 1) MATISSE allows to search for specific observations inside datasets and then analyse them in parallel, providing high-level outputs; 2) the 3D capabilities of both tools are critical in inferring information otherwise difficult to retrieve for non-spherical targets and, as in the case for the GIADA instrument onboard Rosetta, to visualize data related to the coma. New tasks and features adding valuable capabilities to the minor bodies SSDC tools are planned for the near future thanks to new collaborations.
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- 2018
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40. Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.
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McCarroll, Matthew N, Gendelev, Leo, Kinser, Reid, Taylor, Jack, Bruni, Giancarlo, Myers-Turnbull, Douglas, Helsell, Cole, Carbajal, Amanda, Rinaldi, Capria, Kang, Hye Jin, Gong, Jung Ho, Sello, Jason K, Tomita, Susumu, Peterson, Randall T, Keiser, Michael J, and Kokel, David
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Neurons ,Animals ,Zebrafish ,Zebrafish Proteins ,Receptors ,Serotonin ,Receptors ,GABA-A ,Serotonin Antagonists ,Ligands ,Conscious Sedation ,Behavior ,Animal ,Neural Inhibition ,Receptors ,Serotonin ,GABA-A ,Behavior ,Animal - Abstract
Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity-a phenomenon known as paradoxical excitation. Previous studies have identified GABAA receptors as the primary targets of most anesthetic drugs, but how these compounds produce paradoxical excitation is poorly understood. To identify and understand such compounds, we applied a behavior-based drug profiling approach. Here, we show that a subset of central nervous system depressants cause paradoxical excitation in zebrafish. Using this behavior as a readout, we screened thousands of compounds and identified dozens of hits that caused paradoxical excitation. Many hit compounds modulated human GABAA receptors, while others appeared to modulate different neuronal targets, including the human serotonin-6 receptor. Ligands at these receptors generally decreased neuronal activity, but paradoxically increased activity in the caudal hindbrain. Together, these studies identify ligands, targets, and neurons affecting sedation and paradoxical excitation in vivo in zebrafish.
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- 2019
41. Understanding drug–drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs
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Benet, Leslie Z, Bowman, Christine M, Koleske, Megan L, Rinaldi, Capria L, and Sodhi, Jasleen K
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Patient Safety ,Digestive Diseases ,Liver Disease ,Good Health and Well Being ,Area Under Curve ,Drug Interactions ,Half-Life ,Humans ,Metabolic Clearance Rate ,Pharmaceutical Preparations ,Pharmacogenetics ,Drug-drug interactions ,Pharmacogenomics ,Area under the curve ,Operational half-lives ,Maximum systemic concentrations ,Pharmacology & Pharmacy ,Pharmacology and pharmaceutical sciences - Abstract
Here we characterize and summarize the pharmacokinetic changes for metabolized drugs when drug-drug interactions and pharmacogenomic variance are observed. Following multiple dosing to steady-state, oral systemic concentration-time curves appear to follow a one-compartment body model, with a shorter rate limiting half-life, often significantly shorter than the single dose terminal half-life. This simplified disposition model at steady-state allows comparisons of measurable parameters (i.e., area under the curve, half-life, maximum concentration and time to maximum concentration) following drug interaction or pharmacogenomic variant studies to be utilized to characterize whether a drug is low versus high hepatic extraction ratio, even without intravenous dosing. The characteristics of drugs based on the ratios of area under the curve, maximum concentration and half-life are identified with recognition that volume of distribution is essentially unchanged for drug interaction and pharmacogenomic variant studies where only metabolic outcomes are changed and transporters are not significantly involved. Comparison of maximum concentration changes following single dose interaction and pharmacogenomic variance studies may also identify the significance of intestinal first pass changes. The irrelevance of protein binding changes on pharmacodynamic outcomes following oral and intravenous dosing of low hepatic extraction ratio drugs, versus its relevance for high hepatic extraction ratio drugs is re-emphasized.
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- 2019
42. SARS-CoV-2 evolution during persistent infection in a CAR-T recipient shows an escape to both sotrovimab and T-cell responses
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Paola Mazzetti, Pietro Giorgio Spezia, Anna-Lisa Capria, Giulia Freer, Maria Sidoti, Silvia Costarelli, Alice Cara, Alfredo Rosellini, Susi Frateschi, Giovanna Moscato, Iacopo Franconi, Michele Curcio, Maria Linda Vatteroni, Michele Lai, Paola Quaranta, Daniele Focosi, Spartaco Sani, and Mauro Pistello
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Infectious and parasitic diseases ,RC109-216 - Published
- 2023
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43. Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity
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Capria Rinaldi, Christopher S. Waters, Zizheng Li, Karl Kumbier, Lee Rao, R. Jeremy Nichols, Matthew P. Jacobson, Lani F. Wu, and Steven J. Altschuler
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CP: Cell biology ,Biology (General) ,QH301-705.5 - Abstract
Summary: Parkinson’s disease-causing leucine-rich repeat kinase 2 (LRRK2) mutations lead to varying degrees of Rab GTPase hyperphosphorylation. Puzzlingly, LRRK2 GTPase-inactivating mutations—which do not affect intrinsic kinase activity—lead to higher levels of cellular Rab phosphorylation than kinase-activating mutations. Here, we investigate whether mutation-dependent differences in LRRK2 cellular localization could explain this discrepancy. We discover that blocking endosomal maturation leads to the rapid formation of mutant LRRK2+ endosomes on which LRRK2 phosphorylates substrate Rabs. LRRK2+ endosomes are maintained through positive feedback, which mutually reinforces membrane localization of LRRK2 and phosphorylated Rab substrates. Furthermore, across a panel of mutants, cells expressing GTPase-inactivating mutants form strikingly more LRRK2+ endosomes than cells expressing kinase-activating mutants, resulting in higher total cellular levels of phosphorylated Rabs. Our study suggests that the increased probability that LRRK2 GTPase-inactivating mutants are retained on intracellular membranes compared to kinase-activating mutants leads to higher substrate phosphorylation.
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- 2023
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44. Macro and micro structures of pebble-made cometary nuclei reconciled by seasonal evolution
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Ciarniello, Mauro, Fulle, Marco, Raponi, Andrea, Filacchione, Gianrico, Capaccioni, Fabrizio, Rotundi, Alessandra, Rinaldi, Giovanna, Formisano, Michelangelo, Magni, Gianfranco, Tosi, Federico, De Sanctis, Maria Cristina, Capria, Maria Teresa, Longobardo, Andrea, Beck, Pierre, Fornasier, Sonia, Kappel, David, Mennella, Vito, Mottola, Stefano, Rousseau, Batiste, and Arnold, Gabriele
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- 2022
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45. Surface Exospheric Interactions
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Teolis, Ben, Sarantos, Menelaos, Schorghofer, Norbert, Jones, Brant, Grava, Cesare, Mura, Alessandro, Prem, Parvathy, Greenhagen, Ben, Capria, Maria Teresa, Cremonese, Gabriele, Lucchetti, Alice, and Galluzzi, Valentina
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- 2023
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46. ELN2017 risk stratification improves outcome prediction when applied to the prospective GIMEMA AML1310 protocol
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Buccisano, Francesco, Palmieri, Raffaele, Piciocchi, Alfonso, Arena, Valentina, Candoni, Anna, Melillo, Lorella, Calafiore, Valeria, Cairoli, Roberto, de Fabritiis, Paolo, Storti, Gabriella, Salutari, Prassede, Lanza, Francesco, Martinelli, Giovanni, Luppi, Mario, Capria, Saveria, Maurillo, Luca, Del Principe, Maria Ilaria, Paterno, Giovangiacinto, Irno Consalvo, Maria Antonietta, Ottone, Tiziana, Lavorgna, Serena, Voso, Maria Teresa, Fazi, Paola, Vignetti, Marco, Arcese, William, and Venditti, Adriano
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- 2022
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47. The Castalia Mission to Main Belt Comet 133P/Elst-Pizarro
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Snodgrass, C., Jones, G. H., Boehnhardt, H., Gibbings, A., Homeister, M., Andre, N., Beck, P., Bentley, M. S., Bertini, I., Bowles, N., Capria, M. T., Carr, C., Ceriotti, M., Coates, A. J., Della Corte, V., Hanna, K. L. Donaldson, Fitzsimmons, A., Gutierrez, P. J., Hainaut, O. R., Herique, A., Hilchenbach, M., Hsieh, H. H., Jehin, E., Karatekin, O., Kofman, W., Lara, L. M., Laudan, K., Licandro, J., Lowry, S. C., Marzari, F., Masters, A., Meech, K. J., Moreno, F., Morse, A., Orosei, R., Pack, A., Plettemeier, D., Prialnik, D., Rotundi, A., Rubin, M., Sanchez, J. P., Sheridan, S., Trieloff, M., and Winterboer, A.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We describe Castalia, a proposed mission to rendezvous with a Main Belt Comet (MBC), 133P/Elst-Pizarro. MBCs are a recently discovered population of apparently icy bodies within the main asteroid belt between Mars and Jupiter, which may represent the remnants of the population which supplied the early Earth with water. Castalia will perform the first exploration of this population by characterising 133P in detail, solving the puzzle of the MBC's activity, and making the first in situ measurements of water in the asteroid belt. In many ways a successor to ESA's highly successful Rosetta mission, Castalia will allow direct comparison between very different classes of comet, including measuring critical isotope ratios, plasma and dust properties. It will also feature the first radar system to visit a minor body, mapping the ice in the interior. Castalia was proposed, in slightly different versions, to the ESA M4 and M5 calls within the Cosmic Vision programme. We describe the science motivation for the mission, the measurements required to achieve the scientific goals, and the proposed instrument payload and spacecraft to achieve these., Comment: Accepted for publication in Advances in Space Research (special issue on Small Body Exploration). 30 pages
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- 2017
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48. Comet 67P outbursts and quiescent coma at 1.3 AU from the Sun: dust properties from Rosetta/VIRTIS-H observations
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Bockelée-Morvan, D., Rinaldi, G., Erard, S., Leyrat, C., Capaccioni, F., Drossart, P., Filacchione, G., Migliorini, A., Quirico, E., Mottola, S., Tozzi, G., Arnold, G., Biver, N., Combes, M., Crovisier, J., Longobardo, A., Blecka, M., and Capria, M. -T.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We present 2-5 $\mu$m spectroscopic observations of the dust coma of 67P/Churyumov-Gerasimenko obtained with the VIRTIS-H instrument onboard Rosetta during two outbursts that occurred on 2015, 13 September 13.6 h UT and 14 September 18.8 h UT at 1.3 AU from the Sun. Scattering and thermal properties measured before the outburst are in the mean of values measured for moderately active comets. The colour temperature excess (or superheat factor) can be attributed to submicrometre-sized particles composed of absorbing material or to porous fractal-like aggregates such as those collected by the Rosetta in situ dust instruments. The power law index of the dust size distribution is in the range 2-3. The sudden increase of infrared emission associated to the outbursts is correlated with a large increase of the colour temperature (from 300 K to up to 630 K) and a change of the dust colour at 2-2.5 $\mu$m from red to blue colours, revealing the presence of very small grains ($\leq$ 100 nm) in the outburst material. In addition, the measured large bolometric albedos ($\sim$ 0.7) indicate bright grains in the ejecta, which could either be silicatic grains, implying the thermal degradation of the carbonaceous material, or icy grains. The 3-$\mu$m absorption band from water ice is not detected in the spectra acquired during the outbursts, whereas signatures of organic compounds near 3.4 $\mu$m are observed in emission. The H$_2$O 2.7-$\mu$m and CO$_2$ 4.3-$\mu$m vibrational bands do not show any enhancement during the outbursts., Comment: Accepted for publication in the Monthly Notices of the Royal Astronomical Society
- Published
- 2017
- Full Text
- View/download PDF
49. VESPA: a community-driven Virtual Observatory in Planetary Science
- Author
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Erard, S., Cecconi, B., Sidaner, P. Le, Rossi, A. P., Capria, T., Schmitt, B., Génot, V., André, N., Vandaele, A. C., Scherf, M., Hueso, R., Määttänen, A., Thuillot, W., Carry, B., Achilleos, N., Marmo, C., Santolik, O., Benson, K., Fernique, P., Beigbeder, L., Millour, E., Rousseau, B., Andrieu, F., Chauvin, C., Minin, M., Ivanoski, S., Longobardo, A., Bollard, P., Albert, D., Gangloff, M., Jourdane, N., Bouchemit, M., Glorian, J. -M., Trompet, L., Al-Ubaidi, T., Juaristi, J., Desmars, J., Guio, P., Delaa, O., Lagain, A., Soucek, J., and Pisa, D.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
The VESPA data access system focuses on applying Virtual Observatory (VO) standards and tools to Planetary Science. Building on a previous EC-funded Europlanet program, it has reached maturity during the first year of a new Europlanet 2020 program (started in 2015 for 4 years). The infrastructure has been upgraded to handle many fields of Solar System studies, with a focus both on users and data providers. This paper describes the broad lines of the current VESPA infrastructure as seen by a potential user, and provides examples of real use cases in several thematic areas. These use cases are also intended to identify hints for future developments and adaptations of VO tools to Planetary Science., Comment: Planetary and Space Sciences (in press), Special Issue "Enabling Open and Interoperable Access to Planetary Science and Heliophysics Databases and Tools". 43 pages, 14 figures, 1 table
- Published
- 2017
- Full Text
- View/download PDF
50. On the Incompatibility of Special Relativity and Quantum Mechanics
- Author
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Mamone-Capria, Marco
- Subjects
General Relativity and Quantum Cosmology ,Physics - History and Philosophy of Physics - Abstract
Some of the strategies which have been put forward in order to deal with the inconsistency between quantum mechanics and special relativity are examined. The EPR correlations are discussed as a simple example of quantum mechanical macroscopic effects with spacelike separation from their causes. It is shown that they can be used to convey information, whose reliability can be estimated by means of Bayes' theorem. Some of the current reasons advanced to deny that quantum mechanics contradicts special relativity are refuted, and an historical perspective is provided on the issue., Comment: A few misprints corrected. 28 pages. Keywords: EPR correlations, Bohr-Einstein debate, neo-Lorentzian relativity, speed of causal influences, causality reversal, Bayes' theorem
- Published
- 2017
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