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2. Effects of the active amyloid beta immunotherapy CAD106 on PET measurements of amyloid plaque deposition in cognitively unimpaired APOE ε4 homozygotes

Author

Riviere, Marie‐Emmanuelle, primary, Langbaum, Jessica B., additional, Turner, R. Scott, additional, Rinne, Juha O., additional, Sui, Yihan, additional, Cazorla, Pilar, additional, Ricart, Javier, additional, Meneses, Kathleen, additional, Caputo, Angelika, additional, Tariot, Pierre N., additional, Reiman, Eric M., additional, and Graf, Ana, additional

Published
2023
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3. The Alzheimer's Prevention Initiative Generation Program: Study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease

Author

Lopez Lopez, Cristina, Tariot, Pierre N., Caputo, Angelika, Langbaum, Jessica B., Liu, Fonda, Riviere, Marie-Emmanuelle, Langlois, Carolyn, Rouzade-Dominguez, Marie-Laure, Zalesak, Martin, Hendrix, Suzanne, Thomas, Ronald G., Viglietta, Vissia, Lenz, Rob, Ryan, J. Michael, Graf, Ana, and Reiman, Eric M.

Published
2019
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4. Effects of the active amyloid beta immunotherapy CAD106 on PET measurements of amyloid plaque deposition in cognitively unimpaired APOE ε4 homozygotes.

Author

Riviere, Marie‐Emmanuelle, Langbaum, Jessica B., Turner, R. Scott, Rinne, Juha O., Sui, Yihan, Cazorla, Pilar, Ricart, Javier, Meneses, Kathleen, Caputo, Angelika, Tariot, Pierre N., Reiman, Eric M., and Graf, Ana

Abstract

INTRODUCTION: Alzheimer's Prevention Initiative Generation Study 1 evaluated amyloid beta (Aβ) active immunotherapy (vaccine) CAD106 and BACE‐1 inhibitor umibecestat in cognitively unimpaired 60‐ to 75‐year‐old participants at genetic risk for Alzheimer's disease (AD). The study was reduced in size and terminated early. Results from the CAD106 cohort are presented. METHODS: Sixty‐five apolipoprotein E ε4 homozygotes with/without amyloid deposition received intramuscular CAD106 450 μg (n = 42) or placebo (n = 23) at baseline; Weeks 1, 7, 13; and quarterly; 51 of them had follow‐up Aβ positron emission tomography (PET) scans at 18 to 24 months. RESULTS: CAD106 induced measurable serum Aβ immunoglobulin G titers in 41/42 participants, slower rates of Aβ plaque accumulation (mean [standard deviation] annualized change from baseline in amyloid PET Centiloid: −0.91[5.65] for CAD106 versus 8.36 [6.68] for placebo; P < 0.001), and three amyloid‐related imaging abnormality cases (one symptomatic). DISCUSSION: Despite early termination, these findings support the potential value of conducting larger prevention trials of Aβ active immunotherapies in individuals at risk for AD. Highlights: This was the first amyloid‐lowering prevention trial in persons at genetic risk of late‐onset Alzheimer's disease (AD).Active immunotherapy targeting amyloid (CAD106) was tested in this prevention trial.CAD106 significantly slowed down amyloid plaque deposition in apolipoprotein E homozygotes.CAD106 was generally safe and well tolerated, with only three amyloid‐related imaging abnormality cases (one symptomatic).Such an approach deserves further evaluation in larger AD prevention trials. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Diskrete Zufallsvariablen

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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8. Parameterschätzung

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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9. Mehr über Zufallsvariablen und Verteilungen

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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10. Mehrdimensionale Zufallsvariablen

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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12. Stetige Zufallsvariablen

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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13. Wahrscheinlichkeitsrechnung

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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14. Multivariate Deskription und Exploration

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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15. Computeraufgaben

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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16. Regressionsanalyse

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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17. Übergreifende Aufgaben

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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18. Zeitreihen

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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19. Varianzanalyse

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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20. Spezielle Testprobleme

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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21. Testen von Hypothesen

Author

Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, Tutz, Gerhard, Caputo, Angelika, Fahrmeir, Ludwig, Künstler, Rita, Lang, Stefan, Pigeot-Kübler, Iris, and Tutz, Gerhard

Published
2009
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22. Additional file 1 of Rationale for the selection of dual primary endpoints in prevention studies of cognitively unimpaired individuals at genetic risk for developing symptoms of Alzheimer’s disease

Author

Caputo, Angelika, Racine, Amy, Paule, Ines, Tariot, Pierre N., Langbaum, Jessica B., Coello, Neva, Riviere, Marie-Emmanuelle, Ryan, J. Michael, Lopez, Cristina Lopez, and Graf, Ana

Abstract

Additional file 1: Supplemental material. Fig. S1. Cognitive composites over time by genotype: individual time profiles and LOESS estimates for progressors to dementia. Fig. S2. Cross validation of TTE model structure. Fig. S3. Model diagnostic of the APCC model for non-progressors (VPC).

Published
2023
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23. Stetige Zufallsvariablen

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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24. Parameterschätzung

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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25. Mehrdimensionale Zufallsvariablen

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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26. Multivariate Deskription und Exploration

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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28. Diskrete Zufallsvariablen

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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30. Wahrscheinlichkeitsrechnung

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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31. Computeraufgaben

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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32. Zeitreihen

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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33. Varianzanalyse

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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34. Übergreifende Aufgaben

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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35. Spezielle Testprobleme

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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36. Regressionsanalyse

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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37. Testen von Hypothesen

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, Lang, Stefan, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Tutz, Gerhard, Caputo, Angelika, and Lang, Stefan

Published
2003
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38. Diskrete Zufallsvariablen

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, Tutz, Gerhard, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, and Tutz, Gerhard

Published
2001
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39. Parameterschätzung

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, Tutz, Gerhard, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, and Tutz, Gerhard

Published
2001
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40. Mehrdimensionale Zufallsvariablen

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, Tutz, Gerhard, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, and Tutz, Gerhard

Published
2001
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41. Computeraufgaben

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, Tutz, Gerhard, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, and Tutz, Gerhard

Published
2001
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43. Stetige Zufallsvariablen

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, Tutz, Gerhard, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, and Tutz, Gerhard

Published
2001
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44. Wahrscheinlichkeitsrechnung

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, Tutz, Gerhard, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, and Tutz, Gerhard

Published
2001
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45. Zeitreihen

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, Tutz, Gerhard, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, and Tutz, Gerhard

Published
2001
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46. Multivariate Deskription und Exploration

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, Tutz, Gerhard, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, and Tutz, Gerhard

Published
2001
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48. Varianzanalyse

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, Tutz, Gerhard, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, and Tutz, Gerhard

Published
2001
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49. Spezielle Testprobleme

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, Tutz, Gerhard, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, and Tutz, Gerhard

Published
2001
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50. Regressionsanalyse

Author

Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, Tutz, Gerhard, Fahrmeir, Ludwig, Künstler, Rita, Pigeot, Iris, Lang, Stefan, Caputo, Angelika, and Tutz, Gerhard

Published
2001
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