Search

Your search keyword '"Carapetis, J"' showing total 459 results
Start Over Author "Carapetis, J"
459 results on '"Carapetis, J"'

1. Otitis media at 6-monthly assessments of Australian First Nations children between ages 12–36 months: Findings from two randomised controlled trials of combined pneumococcal conjugate vaccines

Author

Leach, A.J., Wilson, N., Arrowsmith, B., Beissbarth, J., Mulholland, E.K., Santosham, M., Torzillo, P.J., McIntyre, P., Smith-Vaughan, H., Skull, S.A., Oguoma, V.M., Chatfield, M., Lehmann, D., Binks, M.J., Licciardi, P.V., Andrews, R., Snelling, T., Krause, V., Carapetis, J., Chang, A.B., and Morris, P.S.

Published
2023
Full Text
View/download PDF

3. Hearing loss at 6-monthly assessments from age 12 to 36 months: secondary outcomes from randomised controlled trials of novel pneumococcal conjugate vaccine schedules

Author

Leach, A.J., primary, Wilson, N., additional, Arrowsmith, B., additional, Beissbarth, J., additional, Mulholland, E.K., additional, Santosham, M., additional, Torzillo, P.J., additional, McIntyre, P., additional, Smith-Vaughan, H., additional, Skull, S.A., additional, Oguoma, V.M., additional, Chatfield, M.D., additional, Lehmann, D., additional, Brennan-Jones, C. G., additional, Binks, M. J., additional, Licciardi, P.V., additional, Andrews, R., additional, Snelling, T., additional, Krause, V., additional, Carapetis, J., additional, Chang, A.B., additional, and Morris, P.S., additional

Published
2024
Full Text
View/download PDF

17. Immunogenicity of a Third Scheduled Dose of Rotarix in Australian Indigenous Infants: A Phase IV, Double-blind, Randomized, Placebo-Controlled Clinical Trial

Author

Middleton, BF, Danchin, M, Jones, MA, Leach, AJ, Cunliffe, N, Kirkwood, CD, Carapetis, J, Gallagher, S, Kirkham, L-A, Granland, C, McNeal, M, Marsh, JA, Waddington, CS, Snelling, TL, Middleton, BF, Danchin, M, Jones, MA, Leach, AJ, Cunliffe, N, Kirkwood, CD, Carapetis, J, Gallagher, S, Kirkham, L-A, Granland, C, McNeal, M, Marsh, JA, Waddington, CS, and Snelling, TL

Abstract

BACKGROUND: Rotarix (GlaxoSmithKline) oral rotavirus vaccine is licensed as 2 doses in the first 6 months of life. In settings with high child mortality rates, clinical protection conferred by 2 doses of Rotarix is reduced. We assessed vaccine immune response when an additional dose of Rotarix was given to Australian Aboriginal children 6 to <12 months old. METHODS: ORVAC is a 2-stage, double-blind, randomized, placebo-controlled trial. Australian Aboriginal children 6 to <12 months old who had received 1 or 2 prior doses of Rotarix rotavirus vaccine were randomized 1:1 to receive an additional dose of Rotarix or matched placebo. The primary immunological end point was seroresponse defined as an anti-rotavirus immunoglobulin A level ≥20 AU/mL, 28-56 days after the additional dose of Rotarix or placebo. RESULTS: Between March 2018 and August 2020, a total of 253 infants were enrolled. Of these, 178 infants (70%) had analyzable serological results after follow-up; 89 were randomized to receive Rotarix, and 89 to receive placebo. The proportion with seroresponse was 85% after Rotarix compared with 72% after placebo. There were no occurrences of intussusception or any serious adverse events. CONCLUSIONS: An additional dose of Rotarix administered to Australian Aboriginal infants 6 to <12 months old increased the proportion with a vaccine seroresponse. CLINICAL TRIALS REGISTRATION: NCT02941107.

Published
2022

18. Risk factors for group A streptococcal pharyngitis and skin infections: A case control study

Author

Bennett, J, Moreland, NJ, Zhang, J, Crane, J, Sika-Paotonu, D, Carapetis, J, Williamson, DA, Baker, MG, Bennett, J, Moreland, NJ, Zhang, J, Crane, J, Sika-Paotonu, D, Carapetis, J, Williamson, DA, and Baker, MG

Abstract

BACKGROUND: Group A streptococcal (GAS) infections can trigger an immune-mediated response resulting in acute rheumatic fever (ARF). The role of social and environmental risk factors for GAS pharyngitis and skin infections are not well understood. This study aimed to identify factors associated with GAS pharyngitis and skin infections, and to determine if these are the same as those for ARF. METHODS: A case-control study, including 733 children aged 5-14 years, was undertaken between March 2018 and October 2019 in Auckland, New Zealand. Healthy controls (n = 190) and symptomatic cases including GAS pharyngitis (n = 210), GAS seronegative carriers (n = 182), and GAS skin infections (n = 151) were recruited. Trained interviewers administered a comprehensive, pre-tested, face-to-face questionnaire. FINDINGS: Multivariable analysis identified strong associations between barriers to accessing primary healthcare and having GAS pharyngitis (adjusted OR 3·3; 95% CI 1·8-6·0), GAS carriage (aOR 2·9; 95% CI 1·5-6·0) or a GAS skin infection (aOR 3·5; 95% CI 1·6-7·6). Children who had GAS skin infections were more likely than all other groups to report living in a crowded home (aOR 1·9; 95% CI 1·0-3·4), have Māori or Pacific grandparents (aOR 3·0; 95% CI 1·2-7·6), a family history of ARF (aOR 2·2; 95% CI 1·1-4·3), or having a previous diagnosis of eczema (aOR 3·9; 95% CI 2·2-6·9). INTERPRETATION: Reducing barriers to accessing primary healthcare (including financial restrictions, the inability to book an appointment, lack of transport, and lack of childcare for other children) to treat GAS pharyngitis and skin infections could potentially reduce these infections and lead to a reduction in their sequelae, including ARF. These strategies should be co-designed and culturally appropriate for the communities being served and carefully evaluated. FUNDING: This work was supported by the Health Research Council of New Zealand (HRC), award number 16/005.

Published
2022

19. Study protocol for controlled human infection for penicillin G against Streptococcus pyogenes: a double-blinded, placebo-controlled, randomised trial to determine the minimum concentration required to prevent experimental pharyngitis (the CHIPS trial)

Author

Hla, TK, Osowicki, J, Salman, S, Batty, KT, Marsh, JA, Kado, J, Barr, R, Enkel, SL, Snelling, TL, McCarthy, J, Steer, AC, Carapetis, J, Manning, L, Hla, TK, Osowicki, J, Salman, S, Batty, KT, Marsh, JA, Kado, J, Barr, R, Enkel, SL, Snelling, TL, McCarthy, J, Steer, AC, Carapetis, J, and Manning, L

Abstract

INTRODUCTION: Regular intramuscular benzathine penicillin G injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. As the pharmacological correlate of protection remains unknown, it is difficult to recommend changes to this established regimen. Determining the minimum effective penicillin exposure required to prevent Streptococcus pyogenes infection will accelerate development of new long-acting penicillins for RHD prevention as well as inform opportunities to improve existing regimens. The CHIPS trial will address this knowledge gap by directly testing protection afforded by different steady state plasma concentrations of penicillin in an established model of experimental human S. pyogenes pharyngitis. METHODS AND ANALYSIS: This is a double-blinded, placebo-controlled, randomised experimental human infection study. Sixty healthy adult volunteers aged 18-40 years will be recruited and randomised 1:1:1:1:1 to continuous intravenous penicillin infusions targeting five different steady state plasma concentrations of 0 (placebo), 3, 6, 12 and 20 ng/mL via a midline catheter. Each participant's penicillin pharmacokinetic parameters will be established prior to the challenge, to ensure accurate dosing for the continuous infusion. Following the challenge with a well-characterised strain of S. pyogenes, participants will be observed for up to 6 days for the development of pharyngitis and treated with antibiotics prior to discharge. The primary objective is to determine the minimum effective steady-state plasma penicillin concentration required to prevent experimental pharyngitis. Secondary objectives will explore systemic and mucosal immunoinflammatory responses during pharyngitis, bacterial colonisation dynamics, environmental contamination and qualitative evaluation of the participant experience. ETHICS AND DISSEMINATION: Ethical approval has been obtained (Bellberry Human Research Ethics Committee). Findings will be r

Published
2022

23. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study

Author

Roth, G, Mensah, G, Johnson, C, Addolorato, G, Ammirati, E, Baddour, L, Barengo, N, Beaton, A, Benjamin, E, Benziger, C, Bonny, A, Brauer, M, Brodmann, M, Cahill, T, Carapetis, J, Catapano, A, Chugh, S, Cooper, L, Coresh, J, Criqui, M, Decleene, N, Eagle, K, Emmons-Bell, S, Feigin, V, Fernandez-Sola, J, Fowkes, G, Gakidou, E, Grundy, S, He, F, Howard, G, Hu, F, Inker, L, Karthikeyan, G, Kassebaum, N, Koroshetz, W, Lavie, C, Lloyd-Jones, D, Lu, H, Mirijello, A, Temesgen, A, Mokdad, A, Moran, A, Muntner, P, Narula, J, Neal, B, Ntsekhe, M, Moraes de Oliveira, G, Otto, C, Owolabi, M, Pratt, M, Rajagopalan, S, Reitsma, M, Ribeiro, A, Rigotti, N, Rodgers, A, Sable, C, Shakil, S, Sliwa-Hahnle, K, Stark, B, Sundstrom, J, Timpel, P, Tleyjeh, I, Valgimigli, M, Vos, T, Whelton, P, Yacoub, M, Zuhlke, L, Murray, C, Fuster, V, Fowkes, F, Misganaw, A, Oliveira, G, Sliwa, K, Abbasi-Kangevari, M, Abdi, A, Abedi, A, Aboyans, V, Abrha, W, Abu-Gharbieh, E, Abushouk, A, Acharya, D, Adair, T, Adebayo, O, Ademi, Z, Advani, S, Afshari, K, Afshin, A, Agarwal, G, Agasthi, P, Ahmad, S, Ahmadi, S, Ahmed, M, Aji, B, Akalu, Y, Akande-Sholabi, W, Aklilu, A, Akunna, C, Alahdab, F, Al-Eyadhy, A, Alhabib, K, Alif, S, Alipour, V, Aljunid, S, Alla, F, Almasi-Hashiani, A, Almustanyir, S, Al-Raddadi, R, Amegah, A, Amini, S, Aminorroaya, A, Amu, H, Amugsi, D, Ancuceanu, R, Anderlini, D, Andrei, T, Andrei, C, Ansari-Moghaddam, A, Anteneh, Z, Antonazzo, I, Antony, B, Anwer, R, Appiah, L, Arabloo, J, Arnlov, J, Artanti, K, Ataro, Z, Ausloos, M, Avila-Burgos, L, Awan, A, Awoke, M, Ayele, H, Ayza, M, Azari, S, B, D, Baheiraei, N, Baig, A, Bakhtiari, A, Banach, M, Banik, P, Baptista, E, Barboza, M, Barua, L, Basu, S, Bedi, N, Bejot, Y, Bennett, D, Bensenor, I, Berman, A, Bezabih, Y, Bhagavathula, A, Bhaskar, S, Bhattacharyya, K, Bijani, A, Bikbov, B, Birhanu, M, Boloor, A, Brant, L, Brenner, H, Briko, N, Butt, Z, Caetano dos Santos, F, Cahill, L, Cahuana-Hurtado, L, Camera, L, Campos-Nonato, I, Cantu-Brito, C, Car, J, Carrero, J, Carvalho, F, Castaneda-Orjuela, C, Catala-Lopez, F, Cerin, E, Charan, J, Chattu, V, Chen, S, Chin, K, Choi, J, Chu, D, Chung, S, Cirillo, M, Coffey, S, Conti, S, Costa, V, Cundiff, D, Dadras, O, Dagnew, B, Dai, X, Damasceno, A, Dandona, L, Dandona, R, Davletov, K, De la Cruz-Gongora, V, De la Hoz, F, De Neve, J, Denova-Gutierrez, E, Derbew Molla, M, Derseh, B, Desai, R, Deuschl, G, Dharmaratne, S, Dhimal, M, Dhungana, R, Dianatinasab, M, Diaz, D, Djalalinia, S, Dokova, K, Douiri, A, Duncan, B, Duraes, A, Eagan, A, Ebtehaj, S, Eftekhari, A, Eftekharzadeh, S, Ekholuenetale, M, El Nahas, N, Elgendy, I, Elhadi, M, El-Jaafary, S, Esteghamati, S, Etisso, A, Eyawo, O, Fadhil, I, Faraon, E, Faris, P, Farwati, M, Farzadfar, F, Fernandes, E, Fernandez Prendes, C, Ferrara, P, Filip, I, Fischer, F, Flood, D, Fukumoto, T, Gad, M, Gaidhane, S, Ganji, M, Garg, J, Gebre, A, Gebregiorgis, B, Gebregzabiher, K, Gebremeskel, G, Getacher, L, Obsa, A, Ghajar, A, Ghashghaee, A, Ghith, N, Giampaoli, S, Gilani, S, Gill, P, Gillum, R, Glushkova, E, Gnedovskaya, E, Golechha, M, Gonfa, K, Goudarzian, A, Goulart, A, Guadamuz, J, Guha, A, Guo, Y, Gupta, R, Hachinski, V, Hafezi-Nejad, N, Haile, T, Hamadeh, R, Hamidi, S, Hankey, G, Hargono, A, Hartono, R, Hashemian, M, Hashi, A, Hassan, S, Hassen, H, Havmoeller, R, Hay, S, Hayat, K, Heidari, G, Herteliu, C, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Iavicoli, I, Ibeneme, C, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Iqbal, U, Irvani, S, Islam, S, Islam, R, Iso, H, Iwagami, M, Jain, V, Javaheri, T, Jayapal, S, Jayaram, S, Jayawardena, R, Jeemon, P, Jha, R, Jonas, J, Jonnagaddala, J, Joukar, F, Jozwiak, J, Jurisson, M, Kabir, A, Kahlon, T, Kalani, R, Kalhor, R, Kamath, A, Kamel, I, Kandel, H, Kandel, A, Karch, A, Kasa, A, Katoto, P, Kayode, G, Khader, Y, Khammarnia, M, Khan, M, Khan, E, Khatab, K, Kibria, G, Kim, Y, Kim, G, Kimokoti, R, Kisa, S, Kisa, A, Kivimaki, M, Kolte, D, Koolivand, A, Korshunov, V, Koulmane Laxminarayana, S, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Kuate Defo, B, Kucuk Bicer, B, Kulkarni, V, Kumar, G, Kumar, N, Kurmi, O, Kusuma, D, Kwan, G, La Vecchia, C, Lacey, B, Lallukka, T, Lan, Q, Lasrado, S, Lassi, Z, Lauriola, P, Lawrence, W, Laxmaiah, A, Legrand, K, Li, M, Li, B, Li, S, Lim, S, Lim, L, Lin, H, Lin, Z, Lin, R, Liu, X, Lopez, A, Lorkowski, S, Lotufo, P, Lugo, A, M, N, Madotto, F, Mahmoudi, M, Majeed, A, Malekzadeh, R, Malik, A, Mamun, A, Manafi, N, Mansournia, M, Mantovani, L, Martini, S, Mathur, M, Mazzaglia, G, Mehata, S, Mehndiratta, M, Meier, T, Menezes, R, Meretoja, A, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, I, Miller, T, Mirrakhimov, E, Mirzaei, H, Moazen, B, Moghadaszadeh, M, Mohammad, Y, Mohammad, D, Mohammed, S, Mohammed, M, Mokhayeri, Y, Molokhia, M, Montasir, A, Moradi, G, Moradzadeh, R, Moraga, P, Morawska, L, Moreno Velasquez, I, Morze, J, Mubarik, S, Muruet, W, Musa, K, Nagarajan, A, Nalini, M, Nangia, V, Naqvi, A, Narasimha Swamy, S, Nascimento, B, Nayak, V, Nazari, J, Nazarzadeh, M, Negoi, R, Neupane Kandel, S, Nguyen, H, Nixon, M, Norrving, B, Noubiap, J, Nouthe, B, Nowak, C, Odukoya, O, Ogbo, F, Olagunju, A, Orru, H, Ortiz, A, Ostroff, S, Padubidri, J, Palladino, R, Pana, A, Panda-Jonas, S, Parekh, U, Park, E, Parvizi, M, Pashazadeh Kan, F, Patel, U, Pathak, M, Paudel, R, Pepito, V, Perianayagam, A, Perico, N, Pham, H, Pilgrim, T, Piradov, M, Pishgar, F, Podder, V, Polibin, R, Pourshams, A, Pribadi, D, Rabiee, N, Rabiee, M, Radfar, A, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Ur Rahman, M, Rahman, M, Rahmani, A, Rakovac, I, Ram, P, Ramalingam, S, Rana, J, Ranasinghe, P, Rao, S, Rathi, P, Rawal, L, Rawasia, W, Rawassizadeh, R, Remuzzi, G, Renzaho, A, Rezapour, A, Riahi, S, Roberts-Thomson, R, Roever, L, Rohloff, P, Romoli, M, Roshandel, G, Rwegerera, G, Saadatagah, S, Saber-Ayad, M, Sabour, S, Sacco, S, Sadeghi, M, Saeedi Moghaddam, S, Safari, S, Sahebkar, A, Salehi, S, Salimzadeh, H, Samaei, M, Samy, A, Santos, I, Santric-Milicevic, M, Sarrafzadegan, N, Sarveazad, A, Sathish, T, Sawhney, M, Saylan, M, Schmidt, M, Schutte, A, Senthilkumaran, S, Sepanlou, S, Sha, F, Shahabi, S, Shahid, I, Shaikh, M, Shamali, M, Shamsizadeh, M, Shawon, M, Sheikh, A, Shigematsu, M, Shin, M, Shin, J, Shiri, R, Shiue, I, Shuval, K, Siabani, S, Siddiqi, T, Silva, D, Singh, J, Mtech, A, Skryabin, V, Skryabina, A, Soheili, A, Spurlock, E, Stockfelt, L, Stortecky, S, Stranges, S, Suliankatchi Abdulkader, R, Tadbiri, H, Tadesse, E, Tadesse, D, Tajdini, M, Tariqujjaman, M, Teklehaimanot, B, Temsah, M, Tesema, A, Thakur, B, Thankappan, K, Thapar, R, Thrift, A, Timalsina, B, Tonelli, M, Touvier, M, Tovani-Palone, M, Tripathi, A, Tripathy, J, Truelsen, T, Tsegay, G, Tsegaye, G, Tsilimparis, N, Tusa, B, Tyrovolas, S, Umapathi, K, Unim, B, Unnikrishnan, B, Usman, M, Vaduganathan, M, Valdez, P, Vasankari, T, Velazquez, D, Venketasubramanian, N, Vu, G, Vujcic, I, Waheed, Y, Wang, Y, Wang, F, Wei, J, Weintraub, R, Weldemariam, A, Westerman, R, Winkler, A, Wiysonge, C, Wolfe, C, Wubishet, B, Xu, G, Yadollahpour, A, Yamagishi, K, Yan, L, Yandrapalli, S, Yano, Y, Yatsuya, H, Yeheyis, T, Yeshaw, Y, Yilgwan, C, Yonemoto, N, Yu, C, Yusefzadeh, H, Zachariah, G, Zaman, S, Zaman, M, Zamanian, M, Zand, R, Zandifar, A, Zarghi, A, Zastrozhin, M, Zastrozhina, A, Zhang, Z, Zhang, Y, Zhang, W, Zhong, C, Zou, Z, Zuniga, Y, Roth G. A., Mensah G. A., Johnson C. O., Addolorato G., Ammirati E., Baddour L. M., Barengo N. C., Beaton A. Z., Benjamin E. J., Benziger C. P., Bonny A., Brauer M., Brodmann M., Cahill T. J., Carapetis J., Catapano A. L., Chugh S. S., Cooper L. T., Coresh J., Criqui M., DeCleene N., Eagle K. A., Emmons-Bell S., Feigin V. L., Fernandez-Sola J., Fowkes G., Gakidou E., Grundy S. M., He F. J., Howard G., Hu F., Inker L., Karthikeyan G., Kassebaum N., Koroshetz W., Lavie C., Lloyd-Jones D., Lu H. S., Mirijello A., Temesgen A. M., Mokdad A., Moran A. E., Muntner P., Narula J., Neal B., Ntsekhe M., Moraes de Oliveira G., Otto C., Owolabi M., Pratt M., Rajagopalan S., Reitsma M., Ribeiro A. L. P., Rigotti N., Rodgers A., Sable C., Shakil S., Sliwa-Hahnle K., Stark B., Sundstrom J., Timpel P., Tleyjeh I. M., Valgimigli M., Vos T., Whelton P. K., Yacoub M., Zuhlke L., Murray C., Fuster V., Beaton A., Carapetis J. R., Chugh S., Criqui M. H., DeCleene N. K., Fowkes F. G. R., Kassebaum N. J., Koroshetz W. J., Misganaw A. T., Mokdad A. H., Oliveira G. M. M., Otto C. M., Owolabi M. O., Reitsma M. B., Rigotti N. A., Sable C. A., Shakil S. S., Sliwa K., Stark B. A., Tleyjeh I. I., Zuhlke L. J., Abbasi-Kangevari M., Abdi A., Abedi A., Aboyans V., Abrha W. A., Abu-Gharbieh E., Abushouk A. I., Acharya D., Adair T., Adebayo O. M., Ademi Z., Advani S. M., Afshari K., Afshin A., Agarwal G., Agasthi P., Ahmad S., Ahmadi S., Ahmed M. B., Aji B., Akalu Y., Akande-Sholabi W., Aklilu A., Akunna C. J., Alahdab F., Al-Eyadhy A., Alhabib K. F., Alif S. M., Alipour V., Aljunid S. M., Alla F., Almasi-Hashiani A., Almustanyir S., Al-Raddadi R. M., Amegah A. K., Amini S., Aminorroaya A., Amu H., Amugsi D. A., Ancuceanu R., Anderlini D., Andrei T., Andrei C. L., Ansari-Moghaddam A., Anteneh Z. A., Antonazzo I. C., Antony B., Anwer R., Appiah L. T., Arabloo J., Arnlov J., Artanti K. D., Ataro Z., Ausloos M., Avila-Burgos L., Awan A. T., Awoke M. A., Ayele H. T., Ayza M. A., Azari S., B D. B., Baheiraei N., Baig A. A., Bakhtiari A., Banach M., Banik P. C., Baptista E. A., Barboza M. A., Barua L., Basu S., Bedi N., Bejot Y., Bennett D. A., Bensenor I. M., Berman A. E., Bezabih Y. M., Bhagavathula A. S., Bhaskar S., Bhattacharyya K., Bijani A., Bikbov B., Birhanu M. M., Boloor A., Brant L. C., Brenner H., Briko N. I., Butt Z. A., Caetano dos Santos F. L., Cahill L. E., Cahuana-Hurtado L., Camera L. A., Campos-Nonato I. R., Cantu-Brito C., Car J., Carrero J. J., Carvalho F., Castaneda-Orjuela C. A., Catala-Lopez F., Cerin E., Charan J., Chattu V. K., Chen S., Chin K. L., Choi J. -Y. J., Chu D. -T., Chung S. -C., Cirillo M., Coffey S., Conti S., Costa V. M., Cundiff D. K., Dadras O., Dagnew B., Dai X., Damasceno A. A. M., Dandona L., Dandona R., Davletov K., De la Cruz-Gongora V., De la Hoz F. P., De Neve J. -W., Denova-Gutierrez E., Derbew Molla M., Derseh B. T., Desai R., Deuschl G., Dharmaratne S. D., Dhimal M., Dhungana R. R., Dianatinasab M., Diaz D., Djalalinia S., Dokova K., Douiri A., Duncan B. B., Duraes A. R., Eagan A. W., Ebtehaj S., Eftekhari A., Eftekharzadeh S., Ekholuenetale M., El Nahas N., Elgendy I. Y., Elhadi M., El-Jaafary S. I., Esteghamati S., Etisso A. E., Eyawo O., Fadhil I., Faraon E. J. A., Faris P. S., Farwati M., Farzadfar F., Fernandes E., Fernandez Prendes C., Ferrara P., Filip I., Fischer F., Flood D., Fukumoto T., Gad M. M., Gaidhane S., Ganji M., Garg J., Gebre A. K., Gebregiorgis B. G., Gebregzabiher K. Z., Gebremeskel G. G., Getacher L., Obsa A. G., Ghajar A., Ghashghaee A., Ghith N., Giampaoli S., Gilani S. A., Gill P. S., Gillum R. F., Glushkova E. V., Gnedovskaya E. V., Golechha M., Gonfa K. B., Goudarzian A. H., Goulart A. C., Guadamuz J. S., Guha A., Guo Y., Gupta R., Hachinski V., Hafezi-Nejad N., Haile T. G., Hamadeh R. R., Hamidi S., Hankey G. J., Hargono A., Hartono R. K., Hashemian M., Hashi A., Hassan S., Hassen H. Y., Havmoeller R. J., Hay S. I., Hayat K., Heidari G., Herteliu C., Holla R., Hosseini M., Hosseinzadeh M., Hostiuc M., Hostiuc S., Househ M., Huang J., Humayun A., Iavicoli I., Ibeneme C. U., Ibitoye S. E., Ilesanmi O. S., Ilic I. M., Ilic M. D., Iqbal U., Irvani S. S. N., Islam S. M. S., Islam R. M., Iso H., Iwagami M., Jain V., Javaheri T., Jayapal S. K., Jayaram S., Jayawardena R., Jeemon P., Jha R. P., Jonas J. B., Jonnagaddala J., Joukar F., Jozwiak J. J., Jurisson M., Kabir A., Kahlon T., Kalani R., Kalhor R., Kamath A., Kamel I., Kandel H., Kandel A., Karch A., Kasa A. S., Katoto P. D. M. C., Kayode G. A., Khader Y. S., Khammarnia M., Khan M. S., Khan M. N., Khan M., Khan E. A., Khatab K., Kibria G. M. A., Kim Y. J., Kim G. R., Kimokoti R. W., Kisa S., Kisa A., Kivimaki M., Kolte D., Koolivand A., Korshunov V. A., Koulmane Laxminarayana S. L., Koyanagi A., Krishan K., Krishnamoorthy V., Kuate Defo B., Kucuk Bicer B., Kulkarni V., Kumar G. A., Kumar N., Kurmi O. P., Kusuma D., Kwan G. F., La Vecchia C., Lacey B., Lallukka T., Lan Q., Lasrado S., Lassi Z. S., Lauriola P., Lawrence W. R., Laxmaiah A., LeGrand K. E., Li M. -C., Li B., Li S., Lim S. S., Lim L. -L., Lin H., Lin Z., Lin R. -T., Liu X., Lopez A. D., Lorkowski S., Lotufo P. A., Lugo A., M N. K., Madotto F., Mahmoudi M., Majeed A., Malekzadeh R., Malik A. A., Mamun A. A., Manafi N., Mansournia M. A., Mantovani L. G., Martini S., Mathur M. R., Mazzaglia G., Mehata S., Mehndiratta M. M., Meier T., Menezes R. G., Meretoja A., Mestrovic T., Miazgowski B., Miazgowski T., Michalek I. M., Miller T. R., Mirrakhimov E. M., Mirzaei H., Moazen B., Moghadaszadeh M., Mohammad Y., Mohammad D. K., Mohammed S., Mohammed M. A., Mokhayeri Y., Molokhia M., Montasir A. A., Moradi G., Moradzadeh R., Moraga P., Morawska L., Moreno Velasquez I., Morze J., Mubarik S., Muruet W., Musa K. I., Nagarajan A. J., Nalini M., Nangia V., Naqvi A. A., Narasimha Swamy S., Nascimento B. R., Nayak V. C., Nazari J., Nazarzadeh M., Negoi R. I., Neupane Kandel S., Nguyen H. L. T., Nixon M. R., Norrving B., Noubiap J. J., Nouthe B. E., Nowak C., Odukoya O. O., Ogbo F. A., Olagunju A. T., Orru H., Ortiz A., Ostroff S. M., Padubidri J. R., Palladino R., Pana A., Panda-Jonas S., Parekh U., Park E. -C., Parvizi M., Pashazadeh Kan F., Patel U. K., Pathak M., Paudel R., Pepito V. C. F., Perianayagam A., Perico N., Pham H. Q., Pilgrim T., Piradov M. A., Pishgar F., Podder V., Polibin R. V., Pourshams A., Pribadi D. R. A., Rabiee N., Rabiee M., Radfar A., Rafiei A., Rahim F., Rahimi-Movaghar V., Ur Rahman M. H., Rahman M. A., Rahmani A. M., Rakovac I., Ram P., Ramalingam S., Rana J., Ranasinghe P., Rao S. J., Rathi P., Rawal L., Rawasia W. F., Rawassizadeh R., Remuzzi G., Renzaho A. M. N., Rezapour A., Riahi S. M., Roberts-Thomson R. L., Roever L., Rohloff P., Romoli M., Roshandel G., Rwegerera G. M., Saadatagah S., Saber-Ayad M. M., Sabour S., Sacco S., Sadeghi M., Saeedi Moghaddam S., Safari S., Sahebkar A., Salehi S., Salimzadeh H., Samaei M., Samy A. M., Santos I. S., Santric-Milicevic M. M., Sarrafzadegan N., Sarveazad A., Sathish T., Sawhney M., Saylan M., Schmidt M. I., Schutte A. E., Senthilkumaran S., Sepanlou S. G., Sha F., Shahabi S., Shahid I., Shaikh M. A., Shamali M., Shamsizadeh M., Shawon M. S. R., Sheikh A., Shigematsu M., Shin M. -J., Shin J. I., Shiri R., Shiue I., Shuval K., Siabani S., Siddiqi T. J., Silva D. A. S., Singh J. A., Mtech A. S., Skryabin V. Y., Skryabina A. A., Soheili A., Spurlock E. E., Stockfelt L., Stortecky S., Stranges S., Suliankatchi Abdulkader R., Tadbiri H., Tadesse E. G., Tadesse D. B., Tajdini M., Tariqujjaman M., Teklehaimanot B. F., Temsah M. -H., Tesema A. K., Thakur B., Thankappan K. R., Thapar R., Thrift A. G., Timalsina B., Tonelli M., Touvier M., Tovani-Palone M. R., Tripathi A., Tripathy J. P., Truelsen T. C., Tsegay G. M., Tsegaye G. W., Tsilimparis N., Tusa B. S., Tyrovolas S., Umapathi K. K., Unim B., Unnikrishnan B., Usman M. S., Vaduganathan M., Valdez P. R., Vasankari T. J., Velazquez D. Z., Venketasubramanian N., Vu G. T., Vujcic I. S., Waheed Y., Wang Y., Wang F., Wei J., Weintraub R. G., Weldemariam A. H., Westerman R., Winkler A. S., Wiysonge C. S., Wolfe C. D. A., Wubishet B. L., Xu G., Yadollahpour A., Yamagishi K., Yan L. L., Yandrapalli S., Yano Y., Yatsuya H., Yeheyis T. Y., Yeshaw Y., Yilgwan C. S., Yonemoto N., Yu C., Yusefzadeh H., Zachariah G., Zaman S. B., Zaman M. S., Zamanian M., Zand R., Zandifar A., Zarghi A., Zastrozhin M. S., Zastrozhina A., Zhang Z. -J., Zhang Y., Zhang W., Zhong C., Zou Z., Zuniga Y. M. H., Murray C. J. L., Roth, G, Mensah, G, Johnson, C, Addolorato, G, Ammirati, E, Baddour, L, Barengo, N, Beaton, A, Benjamin, E, Benziger, C, Bonny, A, Brauer, M, Brodmann, M, Cahill, T, Carapetis, J, Catapano, A, Chugh, S, Cooper, L, Coresh, J, Criqui, M, Decleene, N, Eagle, K, Emmons-Bell, S, Feigin, V, Fernandez-Sola, J, Fowkes, G, Gakidou, E, Grundy, S, He, F, Howard, G, Hu, F, Inker, L, Karthikeyan, G, Kassebaum, N, Koroshetz, W, Lavie, C, Lloyd-Jones, D, Lu, H, Mirijello, A, Temesgen, A, Mokdad, A, Moran, A, Muntner, P, Narula, J, Neal, B, Ntsekhe, M, Moraes de Oliveira, G, Otto, C, Owolabi, M, Pratt, M, Rajagopalan, S, Reitsma, M, Ribeiro, A, Rigotti, N, Rodgers, A, Sable, C, Shakil, S, Sliwa-Hahnle, K, Stark, B, Sundstrom, J, Timpel, P, Tleyjeh, I, Valgimigli, M, Vos, T, Whelton, P, Yacoub, M, Zuhlke, L, Murray, C, Fuster, V, Fowkes, F, Misganaw, A, Oliveira, G, Sliwa, K, Abbasi-Kangevari, M, Abdi, A, Abedi, A, Aboyans, V, Abrha, W, Abu-Gharbieh, E, Abushouk, A, Acharya, D, Adair, T, Adebayo, O, Ademi, Z, Advani, S, Afshari, K, Afshin, A, Agarwal, G, Agasthi, P, Ahmad, S, Ahmadi, S, Ahmed, M, Aji, B, Akalu, Y, Akande-Sholabi, W, Aklilu, A, Akunna, C, Alahdab, F, Al-Eyadhy, A, Alhabib, K, Alif, S, Alipour, V, Aljunid, S, Alla, F, Almasi-Hashiani, A, Almustanyir, S, Al-Raddadi, R, Amegah, A, Amini, S, Aminorroaya, A, Amu, H, Amugsi, D, Ancuceanu, R, Anderlini, D, Andrei, T, Andrei, C, Ansari-Moghaddam, A, Anteneh, Z, Antonazzo, I, Antony, B, Anwer, R, Appiah, L, Arabloo, J, Arnlov, J, Artanti, K, Ataro, Z, Ausloos, M, Avila-Burgos, L, Awan, A, Awoke, M, Ayele, H, Ayza, M, Azari, S, B, D, Baheiraei, N, Baig, A, Bakhtiari, A, Banach, M, Banik, P, Baptista, E, Barboza, M, Barua, L, Basu, S, Bedi, N, Bejot, Y, Bennett, D, Bensenor, I, Berman, A, Bezabih, Y, Bhagavathula, A, Bhaskar, S, Bhattacharyya, K, Bijani, A, Bikbov, B, Birhanu, M, Boloor, A, Brant, L, Brenner, H, Briko, N, Butt, Z, Caetano dos Santos, F, Cahill, L, Cahuana-Hurtado, L, Camera, L, Campos-Nonato, I, Cantu-Brito, C, Car, J, Carrero, J, Carvalho, F, Castaneda-Orjuela, C, Catala-Lopez, F, Cerin, E, Charan, J, Chattu, V, Chen, S, Chin, K, Choi, J, Chu, D, Chung, S, Cirillo, M, Coffey, S, Conti, S, Costa, V, Cundiff, D, Dadras, O, Dagnew, B, Dai, X, Damasceno, A, Dandona, L, Dandona, R, Davletov, K, De la Cruz-Gongora, V, De la Hoz, F, De Neve, J, Denova-Gutierrez, E, Derbew Molla, M, Derseh, B, Desai, R, Deuschl, G, Dharmaratne, S, Dhimal, M, Dhungana, R, Dianatinasab, M, Diaz, D, Djalalinia, S, Dokova, K, Douiri, A, Duncan, B, Duraes, A, Eagan, A, Ebtehaj, S, Eftekhari, A, Eftekharzadeh, S, Ekholuenetale, M, El Nahas, N, Elgendy, I, Elhadi, M, El-Jaafary, S, Esteghamati, S, Etisso, A, Eyawo, O, Fadhil, I, Faraon, E, Faris, P, Farwati, M, Farzadfar, F, Fernandes, E, Fernandez Prendes, C, Ferrara, P, Filip, I, Fischer, F, Flood, D, Fukumoto, T, Gad, M, Gaidhane, S, Ganji, M, Garg, J, Gebre, A, Gebregiorgis, B, Gebregzabiher, K, Gebremeskel, G, Getacher, L, Obsa, A, Ghajar, A, Ghashghaee, A, Ghith, N, Giampaoli, S, Gilani, S, Gill, P, Gillum, R, Glushkova, E, Gnedovskaya, E, Golechha, M, Gonfa, K, Goudarzian, A, Goulart, A, Guadamuz, J, Guha, A, Guo, Y, Gupta, R, Hachinski, V, Hafezi-Nejad, N, Haile, T, Hamadeh, R, Hamidi, S, Hankey, G, Hargono, A, Hartono, R, Hashemian, M, Hashi, A, Hassan, S, Hassen, H, Havmoeller, R, Hay, S, Hayat, K, Heidari, G, Herteliu, C, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Iavicoli, I, Ibeneme, C, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Iqbal, U, Irvani, S, Islam, S, Islam, R, Iso, H, Iwagami, M, Jain, V, Javaheri, T, Jayapal, S, Jayaram, S, Jayawardena, R, Jeemon, P, Jha, R, Jonas, J, Jonnagaddala, J, Joukar, F, Jozwiak, J, Jurisson, M, Kabir, A, Kahlon, T, Kalani, R, Kalhor, R, Kamath, A, Kamel, I, Kandel, H, Kandel, A, Karch, A, Kasa, A, Katoto, P, Kayode, G, Khader, Y, Khammarnia, M, Khan, M, Khan, E, Khatab, K, Kibria, G, Kim, Y, Kim, G, Kimokoti, R, Kisa, S, Kisa, A, Kivimaki, M, Kolte, D, Koolivand, A, Korshunov, V, Koulmane Laxminarayana, S, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Kuate Defo, B, Kucuk Bicer, B, Kulkarni, V, Kumar, G, Kumar, N, Kurmi, O, Kusuma, D, Kwan, G, La Vecchia, C, Lacey, B, Lallukka, T, Lan, Q, Lasrado, S, Lassi, Z, Lauriola, P, Lawrence, W, Laxmaiah, A, Legrand, K, Li, M, Li, B, Li, S, Lim, S, Lim, L, Lin, H, Lin, Z, Lin, R, Liu, X, Lopez, A, Lorkowski, S, Lotufo, P, Lugo, A, M, N, Madotto, F, Mahmoudi, M, Majeed, A, Malekzadeh, R, Malik, A, Mamun, A, Manafi, N, Mansournia, M, Mantovani, L, Martini, S, Mathur, M, Mazzaglia, G, Mehata, S, Mehndiratta, M, Meier, T, Menezes, R, Meretoja, A, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, I, Miller, T, Mirrakhimov, E, Mirzaei, H, Moazen, B, Moghadaszadeh, M, Mohammad, Y, Mohammad, D, Mohammed, S, Mohammed, M, Mokhayeri, Y, Molokhia, M, Montasir, A, Moradi, G, Moradzadeh, R, Moraga, P, Morawska, L, Moreno Velasquez, I, Morze, J, Mubarik, S, Muruet, W, Musa, K, Nagarajan, A, Nalini, M, Nangia, V, Naqvi, A, Narasimha Swamy, S, Nascimento, B, Nayak, V, Nazari, J, Nazarzadeh, M, Negoi, R, Neupane Kandel, S, Nguyen, H, Nixon, M, Norrving, B, Noubiap, J, Nouthe, B, Nowak, C, Odukoya, O, Ogbo, F, Olagunju, A, Orru, H, Ortiz, A, Ostroff, S, Padubidri, J, Palladino, R, Pana, A, Panda-Jonas, S, Parekh, U, Park, E, Parvizi, M, Pashazadeh Kan, F, Patel, U, Pathak, M, Paudel, R, Pepito, V, Perianayagam, A, Perico, N, Pham, H, Pilgrim, T, Piradov, M, Pishgar, F, Podder, V, Polibin, R, Pourshams, A, Pribadi, D, Rabiee, N, Rabiee, M, Radfar, A, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Ur Rahman, M, Rahman, M, Rahmani, A, Rakovac, I, Ram, P, Ramalingam, S, Rana, J, Ranasinghe, P, Rao, S, Rathi, P, Rawal, L, Rawasia, W, Rawassizadeh, R, Remuzzi, G, Renzaho, A, Rezapour, A, Riahi, S, Roberts-Thomson, R, Roever, L, Rohloff, P, Romoli, M, Roshandel, G, Rwegerera, G, Saadatagah, S, Saber-Ayad, M, Sabour, S, Sacco, S, Sadeghi, M, Saeedi Moghaddam, S, Safari, S, Sahebkar, A, Salehi, S, Salimzadeh, H, Samaei, M, Samy, A, Santos, I, Santric-Milicevic, M, Sarrafzadegan, N, Sarveazad, A, Sathish, T, Sawhney, M, Saylan, M, Schmidt, M, Schutte, A, Senthilkumaran, S, Sepanlou, S, Sha, F, Shahabi, S, Shahid, I, Shaikh, M, Shamali, M, Shamsizadeh, M, Shawon, M, Sheikh, A, Shigematsu, M, Shin, M, Shin, J, Shiri, R, Shiue, I, Shuval, K, Siabani, S, Siddiqi, T, Silva, D, Singh, J, Mtech, A, Skryabin, V, Skryabina, A, Soheili, A, Spurlock, E, Stockfelt, L, Stortecky, S, Stranges, S, Suliankatchi Abdulkader, R, Tadbiri, H, Tadesse, E, Tadesse, D, Tajdini, M, Tariqujjaman, M, Teklehaimanot, B, Temsah, M, Tesema, A, Thakur, B, Thankappan, K, Thapar, R, Thrift, A, Timalsina, B, Tonelli, M, Touvier, M, Tovani-Palone, M, Tripathi, A, Tripathy, J, Truelsen, T, Tsegay, G, Tsegaye, G, Tsilimparis, N, Tusa, B, Tyrovolas, S, Umapathi, K, Unim, B, Unnikrishnan, B, Usman, M, Vaduganathan, M, Valdez, P, Vasankari, T, Velazquez, D, Venketasubramanian, N, Vu, G, Vujcic, I, Waheed, Y, Wang, Y, Wang, F, Wei, J, Weintraub, R, Weldemariam, A, Westerman, R, Winkler, A, Wiysonge, C, Wolfe, C, Wubishet, B, Xu, G, Yadollahpour, A, Yamagishi, K, Yan, L, Yandrapalli, S, Yano, Y, Yatsuya, H, Yeheyis, T, Yeshaw, Y, Yilgwan, C, Yonemoto, N, Yu, C, Yusefzadeh, H, Zachariah, G, Zaman, S, Zaman, M, Zamanian, M, Zand, R, Zandifar, A, Zarghi, A, Zastrozhin, M, Zastrozhina, A, Zhang, Z, Zhang, Y, Zhang, W, Zhong, C, Zou, Z, Zuniga, Y, Roth G. A., Mensah G. A., Johnson C. O., Addolorato G., Ammirati E., Baddour L. M., Barengo N. C., Beaton A. Z., Benjamin E. J., Benziger C. P., Bonny A., Brauer M., Brodmann M., Cahill T. J., Carapetis J., Catapano A. L., Chugh S. S., Cooper L. T., Coresh J., Criqui M., DeCleene N., Eagle K. A., Emmons-Bell S., Feigin V. L., Fernandez-Sola J., Fowkes G., Gakidou E., Grundy S. M., He F. J., Howard G., Hu F., Inker L., Karthikeyan G., Kassebaum N., Koroshetz W., Lavie C., Lloyd-Jones D., Lu H. S., Mirijello A., Temesgen A. M., Mokdad A., Moran A. E., Muntner P., Narula J., Neal B., Ntsekhe M., Moraes de Oliveira G., Otto C., Owolabi M., Pratt M., Rajagopalan S., Reitsma M., Ribeiro A. L. P., Rigotti N., Rodgers A., Sable C., Shakil S., Sliwa-Hahnle K., Stark B., Sundstrom J., Timpel P., Tleyjeh I. M., Valgimigli M., Vos T., Whelton P. K., Yacoub M., Zuhlke L., Murray C., Fuster V., Beaton A., Carapetis J. R., Chugh S., Criqui M. H., DeCleene N. K., Fowkes F. G. R., Kassebaum N. J., Koroshetz W. J., Misganaw A. T., Mokdad A. H., Oliveira G. M. M., Otto C. M., Owolabi M. O., Reitsma M. B., Rigotti N. A., Sable C. A., Shakil S. S., Sliwa K., Stark B. A., Tleyjeh I. I., Zuhlke L. J., Abbasi-Kangevari M., Abdi A., Abedi A., Aboyans V., Abrha W. A., Abu-Gharbieh E., Abushouk A. I., Acharya D., Adair T., Adebayo O. M., Ademi Z., Advani S. M., Afshari K., Afshin A., Agarwal G., Agasthi P., Ahmad S., Ahmadi S., Ahmed M. B., Aji B., Akalu Y., Akande-Sholabi W., Aklilu A., Akunna C. J., Alahdab F., Al-Eyadhy A., Alhabib K. F., Alif S. M., Alipour V., Aljunid S. M., Alla F., Almasi-Hashiani A., Almustanyir S., Al-Raddadi R. M., Amegah A. K., Amini S., Aminorroaya A., Amu H., Amugsi D. A., Ancuceanu R., Anderlini D., Andrei T., Andrei C. L., Ansari-Moghaddam A., Anteneh Z. A., Antonazzo I. C., Antony B., Anwer R., Appiah L. T., Arabloo J., Arnlov J., Artanti K. D., Ataro Z., Ausloos M., Avila-Burgos L., Awan A. T., Awoke M. A., Ayele H. T., Ayza M. A., Azari S., B D. B., Baheiraei N., Baig A. A., Bakhtiari A., Banach M., Banik P. C., Baptista E. A., Barboza M. A., Barua L., Basu S., Bedi N., Bejot Y., Bennett D. A., Bensenor I. M., Berman A. E., Bezabih Y. M., Bhagavathula A. S., Bhaskar S., Bhattacharyya K., Bijani A., Bikbov B., Birhanu M. M., Boloor A., Brant L. C., Brenner H., Briko N. I., Butt Z. A., Caetano dos Santos F. L., Cahill L. E., Cahuana-Hurtado L., Camera L. A., Campos-Nonato I. R., Cantu-Brito C., Car J., Carrero J. J., Carvalho F., Castaneda-Orjuela C. A., Catala-Lopez F., Cerin E., Charan J., Chattu V. K., Chen S., Chin K. L., Choi J. -Y. J., Chu D. -T., Chung S. -C., Cirillo M., Coffey S., Conti S., Costa V. M., Cundiff D. K., Dadras O., Dagnew B., Dai X., Damasceno A. A. M., Dandona L., Dandona R., Davletov K., De la Cruz-Gongora V., De la Hoz F. P., De Neve J. -W., Denova-Gutierrez E., Derbew Molla M., Derseh B. T., Desai R., Deuschl G., Dharmaratne S. D., Dhimal M., Dhungana R. R., Dianatinasab M., Diaz D., Djalalinia S., Dokova K., Douiri A., Duncan B. B., Duraes A. R., Eagan A. W., Ebtehaj S., Eftekhari A., Eftekharzadeh S., Ekholuenetale M., El Nahas N., Elgendy I. Y., Elhadi M., El-Jaafary S. I., Esteghamati S., Etisso A. E., Eyawo O., Fadhil I., Faraon E. J. A., Faris P. S., Farwati M., Farzadfar F., Fernandes E., Fernandez Prendes C., Ferrara P., Filip I., Fischer F., Flood D., Fukumoto T., Gad M. M., Gaidhane S., Ganji M., Garg J., Gebre A. K., Gebregiorgis B. G., Gebregzabiher K. Z., Gebremeskel G. G., Getacher L., Obsa A. G., Ghajar A., Ghashghaee A., Ghith N., Giampaoli S., Gilani S. A., Gill P. S., Gillum R. F., Glushkova E. V., Gnedovskaya E. V., Golechha M., Gonfa K. B., Goudarzian A. H., Goulart A. C., Guadamuz J. S., Guha A., Guo Y., Gupta R., Hachinski V., Hafezi-Nejad N., Haile T. G., Hamadeh R. R., Hamidi S., Hankey G. J., Hargono A., Hartono R. K., Hashemian M., Hashi A., Hassan S., Hassen H. Y., Havmoeller R. J., Hay S. I., Hayat K., Heidari G., Herteliu C., Holla R., Hosseini M., Hosseinzadeh M., Hostiuc M., Hostiuc S., Househ M., Huang J., Humayun A., Iavicoli I., Ibeneme C. U., Ibitoye S. E., Ilesanmi O. S., Ilic I. M., Ilic M. D., Iqbal U., Irvani S. S. N., Islam S. M. S., Islam R. M., Iso H., Iwagami M., Jain V., Javaheri T., Jayapal S. K., Jayaram S., Jayawardena R., Jeemon P., Jha R. P., Jonas J. B., Jonnagaddala J., Joukar F., Jozwiak J. J., Jurisson M., Kabir A., Kahlon T., Kalani R., Kalhor R., Kamath A., Kamel I., Kandel H., Kandel A., Karch A., Kasa A. S., Katoto P. D. M. C., Kayode G. A., Khader Y. S., Khammarnia M., Khan M. S., Khan M. N., Khan M., Khan E. A., Khatab K., Kibria G. M. A., Kim Y. J., Kim G. R., Kimokoti R. W., Kisa S., Kisa A., Kivimaki M., Kolte D., Koolivand A., Korshunov V. A., Koulmane Laxminarayana S. L., Koyanagi A., Krishan K., Krishnamoorthy V., Kuate Defo B., Kucuk Bicer B., Kulkarni V., Kumar G. A., Kumar N., Kurmi O. P., Kusuma D., Kwan G. F., La Vecchia C., Lacey B., Lallukka T., Lan Q., Lasrado S., Lassi Z. S., Lauriola P., Lawrence W. R., Laxmaiah A., LeGrand K. E., Li M. -C., Li B., Li S., Lim S. S., Lim L. -L., Lin H., Lin Z., Lin R. -T., Liu X., Lopez A. D., Lorkowski S., Lotufo P. A., Lugo A., M N. K., Madotto F., Mahmoudi M., Majeed A., Malekzadeh R., Malik A. A., Mamun A. A., Manafi N., Mansournia M. A., Mantovani L. G., Martini S., Mathur M. R., Mazzaglia G., Mehata S., Mehndiratta M. M., Meier T., Menezes R. G., Meretoja A., Mestrovic T., Miazgowski B., Miazgowski T., Michalek I. M., Miller T. R., Mirrakhimov E. M., Mirzaei H., Moazen B., Moghadaszadeh M., Mohammad Y., Mohammad D. K., Mohammed S., Mohammed M. A., Mokhayeri Y., Molokhia M., Montasir A. A., Moradi G., Moradzadeh R., Moraga P., Morawska L., Moreno Velasquez I., Morze J., Mubarik S., Muruet W., Musa K. I., Nagarajan A. J., Nalini M., Nangia V., Naqvi A. A., Narasimha Swamy S., Nascimento B. R., Nayak V. C., Nazari J., Nazarzadeh M., Negoi R. I., Neupane Kandel S., Nguyen H. L. T., Nixon M. R., Norrving B., Noubiap J. J., Nouthe B. E., Nowak C., Odukoya O. O., Ogbo F. A., Olagunju A. T., Orru H., Ortiz A., Ostroff S. M., Padubidri J. R., Palladino R., Pana A., Panda-Jonas S., Parekh U., Park E. -C., Parvizi M., Pashazadeh Kan F., Patel U. K., Pathak M., Paudel R., Pepito V. C. F., Perianayagam A., Perico N., Pham H. Q., Pilgrim T., Piradov M. A., Pishgar F., Podder V., Polibin R. V., Pourshams A., Pribadi D. R. A., Rabiee N., Rabiee M., Radfar A., Rafiei A., Rahim F., Rahimi-Movaghar V., Ur Rahman M. H., Rahman M. A., Rahmani A. M., Rakovac I., Ram P., Ramalingam S., Rana J., Ranasinghe P., Rao S. J., Rathi P., Rawal L., Rawasia W. F., Rawassizadeh R., Remuzzi G., Renzaho A. M. N., Rezapour A., Riahi S. M., Roberts-Thomson R. L., Roever L., Rohloff P., Romoli M., Roshandel G., Rwegerera G. M., Saadatagah S., Saber-Ayad M. M., Sabour S., Sacco S., Sadeghi M., Saeedi Moghaddam S., Safari S., Sahebkar A., Salehi S., Salimzadeh H., Samaei M., Samy A. M., Santos I. S., Santric-Milicevic M. M., Sarrafzadegan N., Sarveazad A., Sathish T., Sawhney M., Saylan M., Schmidt M. I., Schutte A. E., Senthilkumaran S., Sepanlou S. G., Sha F., Shahabi S., Shahid I., Shaikh M. A., Shamali M., Shamsizadeh M., Shawon M. S. R., Sheikh A., Shigematsu M., Shin M. -J., Shin J. I., Shiri R., Shiue I., Shuval K., Siabani S., Siddiqi T. J., Silva D. A. S., Singh J. A., Mtech A. S., Skryabin V. Y., Skryabina A. A., Soheili A., Spurlock E. E., Stockfelt L., Stortecky S., Stranges S., Suliankatchi Abdulkader R., Tadbiri H., Tadesse E. G., Tadesse D. B., Tajdini M., Tariqujjaman M., Teklehaimanot B. F., Temsah M. -H., Tesema A. K., Thakur B., Thankappan K. R., Thapar R., Thrift A. G., Timalsina B., Tonelli M., Touvier M., Tovani-Palone M. R., Tripathi A., Tripathy J. P., Truelsen T. C., Tsegay G. M., Tsegaye G. W., Tsilimparis N., Tusa B. S., Tyrovolas S., Umapathi K. K., Unim B., Unnikrishnan B., Usman M. S., Vaduganathan M., Valdez P. R., Vasankari T. J., Velazquez D. Z., Venketasubramanian N., Vu G. T., Vujcic I. S., Waheed Y., Wang Y., Wang F., Wei J., Weintraub R. G., Weldemariam A. H., Westerman R., Winkler A. S., Wiysonge C. S., Wolfe C. D. A., Wubishet B. L., Xu G., Yadollahpour A., Yamagishi K., Yan L. L., Yandrapalli S., Yano Y., Yatsuya H., Yeheyis T. Y., Yeshaw Y., Yilgwan C. S., Yonemoto N., Yu C., Yusefzadeh H., Zachariah G., Zaman S. B., Zaman M. S., Zamanian M., Zand R., Zandifar A., Zarghi A., Zastrozhin M. S., Zastrozhina A., Zhang Z. -J., Zhang Y., Zhang W., Zhong C., Zou Z., Zuniga Y. M. H., and Murray C. J. L.

Abstract

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside

Published
2020

25. Subcutaneous Infusions of High-Dose Benzathine Penicillin G (SCIP) is Safe, Tolerable and Potentially Suitable for Less Frequent Dosing for Rheumatic Heart Disease Secondary Prophylaxis

Author

Kado, J., primary, Salman, S., additional, Hla, T., additional, Enkel, S., additional, Henderson, R., additional, Hand, R., additional, Hort, A., additional, Bennett, J., additional, Anderson, A., additional, Page-Sharp, M., additional, Batty, K., additional, Carapetis, J., additional, and Manning, L., additional

Published
2022
Full Text
View/download PDF

26. Population Pharmacokinetic Study of Benzathine Penicillin G Administration in Indigenous Children and Young Adults With Rheumatic Heart Disease in the Northern Territory, Australia

Author

Kado, J., primary, Salman, S., additional, Hand, R., additional, O'Brien, M., additional, Bowen, A., additional, Page-Sharp, M., additional, Batty, K., additional, Dolman, V., additional, Francis, J., additional, Carapetis, J., additional, and Manning, L., additional

Published
2022
Full Text
View/download PDF

28. Interchangeability, immunogenicity and safety of a combined 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (Synflorix) and 13-valent-PCV (Prevenar13) schedule at 1-2-4-6 months: PREVIX_COMBO, a 3-arm randomised controlled trial.

Author

Leach, AJ, Mulholland, EK, Santosham, M, Torzillo, PJ, McIntyre, P, Smith-Vaughan, H, Wilson, N, Arrowsmith, B, Beissbarth, J, Chatfield, MD, Oguoma, VM, Licciardi, P, Skull, S, Andrews, R, Carapetis, J, McDonnell, J, Krause, V, Morris, PS, Leach, AJ, Mulholland, EK, Santosham, M, Torzillo, PJ, McIntyre, P, Smith-Vaughan, H, Wilson, N, Arrowsmith, B, Beissbarth, J, Chatfield, MD, Oguoma, VM, Licciardi, P, Skull, S, Andrews, R, Carapetis, J, McDonnell, J, Krause, V, and Morris, PS

Abstract

BACKGROUND: Aboriginal children living in remote communities are at high risk of early and persistent otitis media. Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) are primary pathogens. Vaccines with potential to prevent early OM have not been evaluated in this population. We compared immunogenicity (ELISA and opsonophagocytic activity) of a combination of Synflorix™ (PHiD-CV10, 10 serotypes and protein D of NTHi) and Prevenar13™ (PCV13, 10 serotypes plus 3, 6A, and 19A), with recommended schedules. METHODS: This open-label superiority trial randomised (1:1:1) Aboriginal infants at 28 to 38 days of age, to PCV13 (P) at 2-4-6 months (_PPP), PHiD-CV10 (S) at 2-4-6 months (_SSS), or PHiD-CV10 at 1-2-4 plus PCV13 at -6 months (SSSP). Primary outcomes (blinded) were immunogenicity against PCV13-only serotypes 3, 6A, 19A, and PHiD-CV10-only protein D at 7 months. Secondary outcomes include immunogenicity against all serotypes at 2, 4 and 7 months. FINDINGS: Between 2011 and 2017, 425 infants were allocated to _PPP(143), _SSS(141) or SSSP(1 4 1). An intention to treat approach including all available data was used. The SSSP group had superior immunogenicity against serotypes 3, 6A, and 19A compared to _SSS (OPA GMT ratios 8.1 to 59.5, p < 0.001), and against protein D compared to _PPP (GMC ratio 11.9 (95%CI 9.7 to 14.6)). Immune responses to protein D and 3, 6A, and 19A in SSSP were not significantly lower (i.e. no harm) than either _SSS or _PPP. For ten common serotypes responses at 2, 4 and 7 months were superior for SSSP (following 1-, 2-, and 4- doses) than _SSS and _PPP (following 0-, 1-, and 3- doses). At 4 months, _SSS was superior to _PPP. Reactogenicity and hospitalisations were rare and unrelated to the intervention. INTERPRETATION: From two months, the 1-2-4-6-month combined schedule (SSSP) was safe and significantly more immunogenic than 2-4-6-month schedules. The earlier responses may be beneficial in high-risk populations.

Published
2021

30. High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin g injections in ethiopian children and adults with rheumatic heart disease

Author

Ketema, E.B., Gishen, N.Z., Hailu, A., Leul, A., Hadgu, A., Hagos, K., Berhane, S., Tsega, T., Page-Sharp, Madhu, Davis, T.M.E., Moore, Brioni, Batty, Kevin, Carapetis, J., Salman, S., Manning, L., Ketema, E.B., Gishen, N.Z., Hailu, A., Leul, A., Hadgu, A., Hagos, K., Berhane, S., Tsega, T., Page-Sharp, Madhu, Davis, T.M.E., Moore, Brioni, Batty, Kevin, Carapetis, J., Salman, S., and Manning, L.

Abstract

Introduction: Intramuscular benzathine penicillin G (BPG) injections are a cornerstone of secondary prophylaxis to prevent acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Uncer-tainties regarding inter-ethnic and preparation variability, and target exposure profiles of BPG injection are key knowledge gaps for RHD control. Methods: To evaluate BPG pharmacokinetics (PK) in patients receiving 4-weekly doses in Ethiopia, we conducted a prospective cohort study of ARF/RHD patients attending cardiology outpa-tient clinics. Serum samples were collected weekly for one month after injection and assayed with a liquid chromatography-mass spectroscopy assay. Concentration-time data-sets for BPG were analyzed by nonlinear mixed effects modelling using NONMEM. Results: A total of 190 penicillin concentration samples from 74 patients were included in the final PK model. The median age, weight, BMI was 21 years, 47 kg and 18 kg/m2, respectively. When compared with estimates derived from Indigenous Australian patients, the estimate for median (95% confidence interval) volume of distribution (V/F) was lower (54.8 [43.9–66.3] l.70kg-1) whilst the absorption half-life (t1/2-abs2) was longer (12.0 [8.75–17.7] days). The median (IQR) percentage of time where the concentrations remained above 20 ng/mL and 10 ng/mL within the 28-day treatment cycle was 42.5% (27.5–60) and 73% (58.5–99), respectively. Conclusions: The majority of Ethiopian patients receiving BPG as secondary prophylaxis to prevent RHD do not attain target concentrations for more than two weeks during each 4-weekly injection cycle, highlighting the limitations of current BPG strategies. Between-population variation, together with PK differences between different preparations may be important consider-ations for ARF/RHD control programs.

Published
2021

37. Reframe the behaviour: Evaluation of a training intervention to increase capacity in managing detained youth with fetal alcohol spectrum disorder and neurodevelopmental impairments

Author

Passmore, H.M., Mutch, R.C., Watkins, R., Burns, S., Hall, G., Urquhart, J., Carapetis, J., Bower, C., Passmore, H.M., Mutch, R.C., Watkins, R., Burns, S., Hall, G., Urquhart, J., Carapetis, J., and Bower, C.

Abstract

The first study to investigate the prevalence of fetal alcohol spectrum disorder (FASD) within an Australian juvenile detention centre has identified the highest known prevalence of FASD among a justice-involved population worldwide. However, there has been limited investigation into the capacity of the custodial workforce to identify and manage young people in Australian detention centres with FASD or other neurodevelopmental impairment (NDI), and no published interventions aiming to develop environments appropriate for those with FASD in justice settings. Using the Template for Intervention Description and Replication checklist, this study describes the conception, implementation and evaluation of a training intervention aiming to upskill the custodial workforce in the management of youth with FASD and NDI; 117 staff participated in the intervention, and 109 completed pre- and post-intervention surveys. Improvements were seen across almost all knowledge and attitude items, and the intervention was considered highly necessary, appropriate and valuable by the workforce.

Published
2020

38. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

Author

Roth, GA, Mensah, GA, Johnson, CO, Addolorato, G, Ammirati, E, Baddour, LM, Barengo, NC, Beaton, AZ, Benjamin, EJ, Benziger, CP, Bonny, A, Brauer, M, Brodmann, M, Cahill, TJ, Carapetis, J, Catapano, AL, Chugh, SS, Cooper, LT, Coresh, J, Criqui, M, DeCleene, N, Eagle, KA, Emmons-Bell, S, Feigin, VL, Fernández-Solà, J, Fowkes, G, Gakidou, E, Grundy, SM, He, FJ, Howard, G, Hu, F, Inker, L, Karthikeyan, G, Kassebaum, N, Koroshetz, W, Lavie, C, Lloyd-Jones, D, Lu, HS, Mirijello, A, Temesgen, AM, Mokdad, A, Moran, AE, Muntner, P, Narula, J, Neal, B, Ntsekhe, M, Moraes de Oliveira, G, Otto, C, Owolabi, M, Pratt, M, Rajagopalan, S, Reitsma, M, Ribeiro, ALP, Rigotti, N, Rodgers, A, Sable, C, Shakil, S, Sliwa-Hahnle, K, Stark, B, Sundström, J, Timpel, P, Tleyjeh, IM, Valgimigli, M, Vos, T, Whelton, PK, Yacoub, M, Zuhlke, L, Murray, C, Fuster, V, Beaton, A, Carapetis, JR, Chugh, S, Criqui, MH, DeCleene, NK, Fernández-Sola, J, Fowkes, FGR, Kassebaum, NJ, Koroshetz, WJ, Misganaw, AT, Mokdad, AH, Oliveira, GMM, Otto, CM, Owolabi, MO, Reitsma, MB, Rigotti, NA, Sable, CA, Shakil, SS, Sliwa, K, Stark, BA, Tleyjeh, II, Zuhlke, LJ, Abbasi-Kangevari, M, Abdi, A, Abedi, A, Aboyans, V, Abrha, WA, Abu-Gharbieh, E, Abushouk, AI, Acharya, D, Adair, T, Adebayo, OM, Ademi, Z, Advani, SM, Afshari, K, Afshin, A, Agarwal, G, Agasthi, P, Ahmad, S, Ahmadi, S, Ahmed, MB, Aji, B, Akalu, Y, Akande-Sholabi, W, Aklilu, A, Akunna, CJ, Alahdab, F, Al-Eyadhy, A, Alhabib, KF, Alif, SM, Alipour, V, Aljunid, SM, Alla, F, Almasi-Hashiani, A, Almustanyir, S, Al-Raddadi, RM, Amegah, AK, Amini, S, Aminorroaya, A, Amu, H, Amugsi, DA, Ancuceanu, R, Anderlini, D, Andrei, T, Andrei, CL, Ansari-Moghaddam, A, Anteneh, ZA, Antonazzo, IC, Antony, B, Anwer, R, Appiah, LT, Arabloo, J, Ärnlöv, J, Artanti, KD, Ataro, Z, Ausloos, M, Avila-Burgos, L, Awan, AT, Awoke, MA, Ayele, HT, Ayza, MA, Azari, S, B, DB, Baheiraei, N, Baig, AA, Bakhtiari, A, Banach, M, Banik, PC, Baptista, EA, Barboza, MA, Barua, L, Basu, S, Bedi, N, Béjot, Y, Bennett, DA, Bensenor, IM, Berman, AE, Bezabih, YM, Bhagavathula, AS, Bhaskar, S, Bhattacharyya, K, Bijani, A, Bikbov, B, Birhanu, MM, Boloor, A, Brant, LC, Brenner, H, Briko, NI, Butt, ZA, Caetano dos Santos, FL, Cahill, LE, Cahuana-Hurtado, L, Cámera, LA, Campos-Nonato, IR, Cantu-Brito, C, Car, J, Carrero, JJ, Carvalho, F, Castañeda-Orjuela, CA, Catalá-López, F, Cerin, E, Charan, J, Chattu, VK, Chen, S, Chin, KL, Choi, J-YJ, Chu, D-T, Chung, S-C, Cirillo, M, Coffey, S, Conti, S, Costa, VM, Cundiff, DK, Dadras, O, Dagnew, B, Dai, X, Damasceno, AAM, Dandona, L, Dandona, R, Davletov, K, De la Cruz-Góngora, V, De la Hoz, FP, De Neve, J-W, Denova-Gutiérrez, E, Derbew Molla, M, Derseh, BT, Desai, R, Deuschl, G, Dharmaratne, SD, Dhimal, M, Dhungana, RR, Dianatinasab, M, Diaz, D, Djalalinia, S, Dokova, K, Douiri, A, Duncan, BB, Duraes, AR, Eagan, AW, Ebtehaj, S, Eftekhari, A, Eftekharzadeh, S, Ekholuenetale, M, El Nahas, N, Elgendy, IY, Elhadi, M, El-Jaafary, SI, Esteghamati, S, Etisso, AE, Eyawo, O, Fadhil, I, Faraon, EJA, Faris, PS, Farwati, M, Farzadfar, F, Fernandes, E, Fernandez Prendes, C, Ferrara, P, Filip, I, Fischer, F, Flood, D, Fukumoto, T, Gad, MM, Gaidhane, S, Ganji, M, Garg, J, Gebre, AK, Gebregiorgis, BG, Gebregzabiher, KZ, Gebremeskel, GG, Getacher, L, Obsa, AG, Ghajar, A, Ghashghaee, A, Ghith, N, Giampaoli, S, Gilani, SA, Gill, PS, Gillum, RF, Glushkova, EV, Gnedovskaya, EV, Golechha, M, Gonfa, KB, Goudarzian, AH, Goulart, AC, Guadamuz, JS, Guha, A, Guo, Y, Gupta, R, Hachinski, V, Hafezi-Nejad, N, Haile, TG, Hamadeh, RR, Hamidi, S, Hankey, GJ, Hargono, A, Hartono, RK, Hashemian, M, Hashi, A, Hassan, S, Hassen, HY, Havmoeller, RJ, Hay, SI, Hayat, K, Heidari, G, Herteliu, C, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Iavicoli, I, Ibeneme, CU, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Iqbal, U, Irvani, SSN, Shariful Islam, Sheikh, Islam, RM, Iso, H, Iwagami, M, Jain, V, Javaheri, T, Jayapal, SK, Jayaram, S, Jayawardena, R, Jeemon, P, Jha, RP, Jonas, JB, Jonnagaddala, J, Joukar, F, Jozwiak, JJ, Jürisson, M, Kabir, A, Kahlon, T, Kalani, R, Kalhor, R, Kamath, A, Kamel, I, Kandel, H, Kandel, A, Karch, A, Kasa, AS, Katoto, PDMC, Kayode, GA, Khader, YS, Khammarnia, M, Khan, MS, Khan, MN, Khan, M, Khan, EA, Khatab, K, Kibria, GMA, Kim, YJ, Kim, GR, Kimokoti, RW, Kisa, S, Kisa, A, Kivimäki, M, Kolte, D, Koolivand, A, Korshunov, VA, Koulmane Laxminarayana, SL, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Kuate Defo, B, Kucuk Bicer, B, Kulkarni, V, Kumar, GA, Kumar, N, Kurmi, OP, Kusuma, D, Kwan, GF, La Vecchia, C, Lacey, B, Lallukka, T, Lan, Q, Lasrado, S, Lassi, ZS, Lauriola, P, Lawrence, WR, Laxmaiah, A, LeGrand, KE, Li, M-C, Li, B, Li, S, Lim, SS, Lim, L-L, Lin, H, Lin, Z, Lin, R-T, Liu, X, Lopez, AD, Lorkowski, S, Lotufo, PA, Lugo, A, M, NK, Madotto, F, Mahmoudi, M, Majeed, A, Malekzadeh, R, Malik, AA, Mamun, AA, Manafi, N, Mansournia, MA, Mantovani, LG, Martini, S, Mathur, MR, Mazzaglia, G, Mehata, S, Mehndiratta, MM, Meier, T, Menezes, RG, Meretoja, A, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirrakhimov, EM, Mirzaei, H, Moazen, B, Moghadaszadeh, M, Mohammad, Y, Mohammad, DK, Mohammed, S, Mohammed, MA, Mokhayeri, Y, Molokhia, M, Montasir, AA, Moradi, G, Moradzadeh, R, Moraga, P, Morawska, L, Moreno Velásquez, I, Morze, J, Mubarik, S, Muruet, W, Musa, KI, Nagarajan, AJ, Nalini, M, Nangia, V, Naqvi, AA, Narasimha Swamy, S, Nascimento, BR, Nayak, VC, Nazari, J, Nazarzadeh, M, Negoi, RI, Neupane Kandel, S, Nguyen, HLT, Nixon, MR, Norrving, B, Noubiap, JJ, Nouthe, BE, Nowak, C, Odukoya, OO, Ogbo, FA, Olagunju, AT, Orru, H, Ortiz, A, Ostroff, SM, Padubidri, JR, Palladino, R, Pana, A, Panda-Jonas, S, Parekh, U, Park, E-C, Parvizi, M, Pashazadeh Kan, F, Patel, UK, Pathak, M, Paudel, R, Pepito, VCF, Perianayagam, A, Perico, N, Pham, HQ, Pilgrim, T, Piradov, MA, Pishgar, F, Podder, V, Polibin, RV, Pourshams, A, Pribadi, DRA, Rabiee, N, Rabiee, M, Radfar, A, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Ur Rahman, MH, Rahman, Muhammad, Rahmani, AM, Rakovac, I, Ram, P, Ramalingam, S, Rana, J, Ranasinghe, P, Rao, SJ, Rathi, P, Rawal, L, Rawasia, WF, Rawassizadeh, R, Remuzzi, G, Renzaho, AMN, Rezapour, A, Riahi, SM, Roberts-Thomson, RL, Roever, L, Rohloff, P, Romoli, M, Roshandel, G, Rwegerera, GM, Saadatagah, S, Saber-Ayad, MM, Sabour, S, Sacco, S, Sadeghi, M, Saeedi Moghaddam, S, Safari, S, Sahebkar, A, Salehi, S, Salimzadeh, H, Samaei, M, Samy, AM, Santos, IS, Santric-Milicevic, MM, Sarrafzadegan, N, Sarveazad, A, Sathish, T, Sawhney, M, Saylan, M, Schmidt, MI, Schutte, AE, Senthilkumaran, S, Sepanlou, SG, Sha, F, Shahabi, S, Shahid, I, Shaikh, MA, Shamali, M, Shamsizadeh, M, Shawon, MSR, Sheikh, A, Shigematsu, M, Shin, M-J, Shin, JI, Shiri, R, Shiue, I, Shuval, K, Siabani, S, Siddiqi, TJ, Silva, DAS, Singh, JA, Mtech, AS, Skryabin, VY, Skryabina, AA, Soheili, A, Spurlock, EE, Stockfelt, L, Stortecky, S, Stranges, S, Suliankatchi Abdulkader, R, Tadbiri, H, Tadesse, EG, Tadesse, DB, Tajdini, M, Tariqujjaman, M, Teklehaimanot, BF, Temsah, M-H, Tesema, AK, Thakur, B, Thankappan, KR, Thapar, R, Thrift, AG, Timalsina, B, Tonelli, M, Touvier, M, Tovani-Palone, MR, Tripathi, A, Tripathy, JP, Truelsen, TC, Tsegay, GM, Tsegaye, GW, Tsilimparis, N, Tusa, BS, Tyrovolas, S, Umapathi, KK, Unim, B, Unnikrishnan, B, Usman, MS, Vaduganathan, M, Valdez, PR, Vasankari, TJ, Velazquez, DZ, Venketasubramanian, N, Vu, GT, Vujcic, IS, Waheed, Y, Wang, Y, Wang, F, Wei, J, Weintraub, RG, Weldemariam, AH, Westerman, R, Winkler, AS, Wiysonge, CS, Wolfe, CDA, Wubishet, BL, Xu, G, Yadollahpour, A, Yamagishi, K, Yan, LL, Yandrapalli, S, Yano, Y, Yatsuya, H, Yeheyis, TY, Yeshaw, Y, Yilgwan, CS, Yonemoto, N, Yu, C, Yusefzadeh, H, Zachariah, G, Zaman, SB, Zaman, MS, Zamanian, M, Zand, R, Zandifar, A, Zarghi, A, Zastrozhin, MS, Zastrozhina, A, Zhang, Z-J, Zhang, Y, Zhang, W, Zhong, C, Zou, Z, Zuniga, YMH, Murray, CJL, Roth, GA, Mensah, GA, Johnson, CO, Addolorato, G, Ammirati, E, Baddour, LM, Barengo, NC, Beaton, AZ, Benjamin, EJ, Benziger, CP, Bonny, A, Brauer, M, Brodmann, M, Cahill, TJ, Carapetis, J, Catapano, AL, Chugh, SS, Cooper, LT, Coresh, J, Criqui, M, DeCleene, N, Eagle, KA, Emmons-Bell, S, Feigin, VL, Fernández-Solà, J, Fowkes, G, Gakidou, E, Grundy, SM, He, FJ, Howard, G, Hu, F, Inker, L, Karthikeyan, G, Kassebaum, N, Koroshetz, W, Lavie, C, Lloyd-Jones, D, Lu, HS, Mirijello, A, Temesgen, AM, Mokdad, A, Moran, AE, Muntner, P, Narula, J, Neal, B, Ntsekhe, M, Moraes de Oliveira, G, Otto, C, Owolabi, M, Pratt, M, Rajagopalan, S, Reitsma, M, Ribeiro, ALP, Rigotti, N, Rodgers, A, Sable, C, Shakil, S, Sliwa-Hahnle, K, Stark, B, Sundström, J, Timpel, P, Tleyjeh, IM, Valgimigli, M, Vos, T, Whelton, PK, Yacoub, M, Zuhlke, L, Murray, C, Fuster, V, Beaton, A, Carapetis, JR, Chugh, S, Criqui, MH, DeCleene, NK, Fernández-Sola, J, Fowkes, FGR, Kassebaum, NJ, Koroshetz, WJ, Misganaw, AT, Mokdad, AH, Oliveira, GMM, Otto, CM, Owolabi, MO, Reitsma, MB, Rigotti, NA, Sable, CA, Shakil, SS, Sliwa, K, Stark, BA, Tleyjeh, II, Zuhlke, LJ, Abbasi-Kangevari, M, Abdi, A, Abedi, A, Aboyans, V, Abrha, WA, Abu-Gharbieh, E, Abushouk, AI, Acharya, D, Adair, T, Adebayo, OM, Ademi, Z, Advani, SM, Afshari, K, Afshin, A, Agarwal, G, Agasthi, P, Ahmad, S, Ahmadi, S, Ahmed, MB, Aji, B, Akalu, Y, Akande-Sholabi, W, Aklilu, A, Akunna, CJ, Alahdab, F, Al-Eyadhy, A, Alhabib, KF, Alif, SM, Alipour, V, Aljunid, SM, Alla, F, Almasi-Hashiani, A, Almustanyir, S, Al-Raddadi, RM, Amegah, AK, Amini, S, Aminorroaya, A, Amu, H, Amugsi, DA, Ancuceanu, R, Anderlini, D, Andrei, T, Andrei, CL, Ansari-Moghaddam, A, Anteneh, ZA, Antonazzo, IC, Antony, B, Anwer, R, Appiah, LT, Arabloo, J, Ärnlöv, J, Artanti, KD, Ataro, Z, Ausloos, M, Avila-Burgos, L, Awan, AT, Awoke, MA, Ayele, HT, Ayza, MA, Azari, S, B, DB, Baheiraei, N, Baig, AA, Bakhtiari, A, Banach, M, Banik, PC, Baptista, EA, Barboza, MA, Barua, L, Basu, S, Bedi, N, Béjot, Y, Bennett, DA, Bensenor, IM, Berman, AE, Bezabih, YM, Bhagavathula, AS, Bhaskar, S, Bhattacharyya, K, Bijani, A, Bikbov, B, Birhanu, MM, Boloor, A, Brant, LC, Brenner, H, Briko, NI, Butt, ZA, Caetano dos Santos, FL, Cahill, LE, Cahuana-Hurtado, L, Cámera, LA, Campos-Nonato, IR, Cantu-Brito, C, Car, J, Carrero, JJ, Carvalho, F, Castañeda-Orjuela, CA, Catalá-López, F, Cerin, E, Charan, J, Chattu, VK, Chen, S, Chin, KL, Choi, J-YJ, Chu, D-T, Chung, S-C, Cirillo, M, Coffey, S, Conti, S, Costa, VM, Cundiff, DK, Dadras, O, Dagnew, B, Dai, X, Damasceno, AAM, Dandona, L, Dandona, R, Davletov, K, De la Cruz-Góngora, V, De la Hoz, FP, De Neve, J-W, Denova-Gutiérrez, E, Derbew Molla, M, Derseh, BT, Desai, R, Deuschl, G, Dharmaratne, SD, Dhimal, M, Dhungana, RR, Dianatinasab, M, Diaz, D, Djalalinia, S, Dokova, K, Douiri, A, Duncan, BB, Duraes, AR, Eagan, AW, Ebtehaj, S, Eftekhari, A, Eftekharzadeh, S, Ekholuenetale, M, El Nahas, N, Elgendy, IY, Elhadi, M, El-Jaafary, SI, Esteghamati, S, Etisso, AE, Eyawo, O, Fadhil, I, Faraon, EJA, Faris, PS, Farwati, M, Farzadfar, F, Fernandes, E, Fernandez Prendes, C, Ferrara, P, Filip, I, Fischer, F, Flood, D, Fukumoto, T, Gad, MM, Gaidhane, S, Ganji, M, Garg, J, Gebre, AK, Gebregiorgis, BG, Gebregzabiher, KZ, Gebremeskel, GG, Getacher, L, Obsa, AG, Ghajar, A, Ghashghaee, A, Ghith, N, Giampaoli, S, Gilani, SA, Gill, PS, Gillum, RF, Glushkova, EV, Gnedovskaya, EV, Golechha, M, Gonfa, KB, Goudarzian, AH, Goulart, AC, Guadamuz, JS, Guha, A, Guo, Y, Gupta, R, Hachinski, V, Hafezi-Nejad, N, Haile, TG, Hamadeh, RR, Hamidi, S, Hankey, GJ, Hargono, A, Hartono, RK, Hashemian, M, Hashi, A, Hassan, S, Hassen, HY, Havmoeller, RJ, Hay, SI, Hayat, K, Heidari, G, Herteliu, C, Holla, R, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Humayun, A, Iavicoli, I, Ibeneme, CU, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Iqbal, U, Irvani, SSN, Shariful Islam, Sheikh, Islam, RM, Iso, H, Iwagami, M, Jain, V, Javaheri, T, Jayapal, SK, Jayaram, S, Jayawardena, R, Jeemon, P, Jha, RP, Jonas, JB, Jonnagaddala, J, Joukar, F, Jozwiak, JJ, Jürisson, M, Kabir, A, Kahlon, T, Kalani, R, Kalhor, R, Kamath, A, Kamel, I, Kandel, H, Kandel, A, Karch, A, Kasa, AS, Katoto, PDMC, Kayode, GA, Khader, YS, Khammarnia, M, Khan, MS, Khan, MN, Khan, M, Khan, EA, Khatab, K, Kibria, GMA, Kim, YJ, Kim, GR, Kimokoti, RW, Kisa, S, Kisa, A, Kivimäki, M, Kolte, D, Koolivand, A, Korshunov, VA, Koulmane Laxminarayana, SL, Koyanagi, A, Krishan, K, Krishnamoorthy, V, Kuate Defo, B, Kucuk Bicer, B, Kulkarni, V, Kumar, GA, Kumar, N, Kurmi, OP, Kusuma, D, Kwan, GF, La Vecchia, C, Lacey, B, Lallukka, T, Lan, Q, Lasrado, S, Lassi, ZS, Lauriola, P, Lawrence, WR, Laxmaiah, A, LeGrand, KE, Li, M-C, Li, B, Li, S, Lim, SS, Lim, L-L, Lin, H, Lin, Z, Lin, R-T, Liu, X, Lopez, AD, Lorkowski, S, Lotufo, PA, Lugo, A, M, NK, Madotto, F, Mahmoudi, M, Majeed, A, Malekzadeh, R, Malik, AA, Mamun, AA, Manafi, N, Mansournia, MA, Mantovani, LG, Martini, S, Mathur, MR, Mazzaglia, G, Mehata, S, Mehndiratta, MM, Meier, T, Menezes, RG, Meretoja, A, Mestrovic, T, Miazgowski, B, Miazgowski, T, Michalek, IM, Miller, TR, Mirrakhimov, EM, Mirzaei, H, Moazen, B, Moghadaszadeh, M, Mohammad, Y, Mohammad, DK, Mohammed, S, Mohammed, MA, Mokhayeri, Y, Molokhia, M, Montasir, AA, Moradi, G, Moradzadeh, R, Moraga, P, Morawska, L, Moreno Velásquez, I, Morze, J, Mubarik, S, Muruet, W, Musa, KI, Nagarajan, AJ, Nalini, M, Nangia, V, Naqvi, AA, Narasimha Swamy, S, Nascimento, BR, Nayak, VC, Nazari, J, Nazarzadeh, M, Negoi, RI, Neupane Kandel, S, Nguyen, HLT, Nixon, MR, Norrving, B, Noubiap, JJ, Nouthe, BE, Nowak, C, Odukoya, OO, Ogbo, FA, Olagunju, AT, Orru, H, Ortiz, A, Ostroff, SM, Padubidri, JR, Palladino, R, Pana, A, Panda-Jonas, S, Parekh, U, Park, E-C, Parvizi, M, Pashazadeh Kan, F, Patel, UK, Pathak, M, Paudel, R, Pepito, VCF, Perianayagam, A, Perico, N, Pham, HQ, Pilgrim, T, Piradov, MA, Pishgar, F, Podder, V, Polibin, RV, Pourshams, A, Pribadi, DRA, Rabiee, N, Rabiee, M, Radfar, A, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Ur Rahman, MH, Rahman, Muhammad, Rahmani, AM, Rakovac, I, Ram, P, Ramalingam, S, Rana, J, Ranasinghe, P, Rao, SJ, Rathi, P, Rawal, L, Rawasia, WF, Rawassizadeh, R, Remuzzi, G, Renzaho, AMN, Rezapour, A, Riahi, SM, Roberts-Thomson, RL, Roever, L, Rohloff, P, Romoli, M, Roshandel, G, Rwegerera, GM, Saadatagah, S, Saber-Ayad, MM, Sabour, S, Sacco, S, Sadeghi, M, Saeedi Moghaddam, S, Safari, S, Sahebkar, A, Salehi, S, Salimzadeh, H, Samaei, M, Samy, AM, Santos, IS, Santric-Milicevic, MM, Sarrafzadegan, N, Sarveazad, A, Sathish, T, Sawhney, M, Saylan, M, Schmidt, MI, Schutte, AE, Senthilkumaran, S, Sepanlou, SG, Sha, F, Shahabi, S, Shahid, I, Shaikh, MA, Shamali, M, Shamsizadeh, M, Shawon, MSR, Sheikh, A, Shigematsu, M, Shin, M-J, Shin, JI, Shiri, R, Shiue, I, Shuval, K, Siabani, S, Siddiqi, TJ, Silva, DAS, Singh, JA, Mtech, AS, Skryabin, VY, Skryabina, AA, Soheili, A, Spurlock, EE, Stockfelt, L, Stortecky, S, Stranges, S, Suliankatchi Abdulkader, R, Tadbiri, H, Tadesse, EG, Tadesse, DB, Tajdini, M, Tariqujjaman, M, Teklehaimanot, BF, Temsah, M-H, Tesema, AK, Thakur, B, Thankappan, KR, Thapar, R, Thrift, AG, Timalsina, B, Tonelli, M, Touvier, M, Tovani-Palone, MR, Tripathi, A, Tripathy, JP, Truelsen, TC, Tsegay, GM, Tsegaye, GW, Tsilimparis, N, Tusa, BS, Tyrovolas, S, Umapathi, KK, Unim, B, Unnikrishnan, B, Usman, MS, Vaduganathan, M, Valdez, PR, Vasankari, TJ, Velazquez, DZ, Venketasubramanian, N, Vu, GT, Vujcic, IS, Waheed, Y, Wang, Y, Wang, F, Wei, J, Weintraub, RG, Weldemariam, AH, Westerman, R, Winkler, AS, Wiysonge, CS, Wolfe, CDA, Wubishet, BL, Xu, G, Yadollahpour, A, Yamagishi, K, Yan, LL, Yandrapalli, S, Yano, Y, Yatsuya, H, Yeheyis, TY, Yeshaw, Y, Yilgwan, CS, Yonemoto, N, Yu, C, Yusefzadeh, H, Zachariah, G, Zaman, SB, Zaman, MS, Zamanian, M, Zand, R, Zandifar, A, Zarghi, A, Zastrozhin, MS, Zastrozhina, A, Zhang, Z-J, Zhang, Y, Zhang, W, Zhong, C, Zou, Z, Zuniga, YMH, and Murray, CJL

Abstract

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019.Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019.Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside hi

Published
2020

39. 10-Valent pneumococcal non-typeable H. influenzae protein D conjugate vaccine (PHiD-CV10) versus 13-valent pneumococcal conjugate vaccine (PCV13) as a booster dose to broaden and strengthen protection from otitis media (PREVIX_BOOST) in Australian Aboriginal children: study protocol for a randomised controlled trial.

Author

Oguoma, VM, Wilson, N, Mulholland, K, Santosham, M, Torzillo, P, McIntyre, P, Smith-Vaughan, H, Balloch, A, Chatfield, M, Lehmann, D, Binks, MJ, Chang, A, Carapetis, J, Krause, V, Andrews, R, Snelling, T, Licciardi, P, Morris, P, Leach, AJ, Oguoma, VM, Wilson, N, Mulholland, K, Santosham, M, Torzillo, P, McIntyre, P, Smith-Vaughan, H, Balloch, A, Chatfield, M, Lehmann, D, Binks, MJ, Chang, A, Carapetis, J, Krause, V, Andrews, R, Snelling, T, Licciardi, P, Morris, P, and Leach, AJ

Abstract

INTRODUCTION: Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) are major otitis media pathogens that densely co-colonise the nasopharynx and infect the middle ear of Australian Aboriginal infants from very early in life. Our co-primary hypotheses are that at 18 months of age infants receiving 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) compared with those receiving 13-valent pneumococcal conjugate vaccine (PCV13) as a booster at 12 months of age will have higher antibody levels to Haemophilus influenzae protein D and that infants receiving PCV13 will have higher antibody levels to PCV13-only serotypes 3, 6A and 19A. METHODS AND ANALYSES: Our randomised controlled trial will enrol 270 Aboriginal children at 12 months of age to a booster dose of either PHiD-CV10 or PCV13. Children who completed the three-dose primary course schedules of PHiD-CV10 at 2, 4, 6 months of age; PCV13 at 2, 4, 6 months of age; or a combination schedule of PHiD-CV10 at 1, 2, 4 months of age plus PCV13 at 6 months of age are eligible. The co-primary assessor-blinded outcomes when the infants are 18 months of age are as follows: (a) IgG geometric mean concentration (GMC) and proportion with IgG ≥100 EU/mL for protein D, and (b) IgG GMC and the proportion with IgG ≥0.35 µg/mL for pneumococcal serotypes 3, 6A and 19A. Secondary immunogenicity comparisons of six primary and booster dose schedules of 10 shared serotypes at 18 months of age, nasopharyngeal carriage, all forms of otitis media, hearing loss and developmental milestones at 18, 24, 30 and 36 months of age will be reported. ETHICS AND DISSEMINATION: Ethics committees of NT Department of Health, Menzies, WA Department of Health and WA Aboriginal Health approved the study. Results will be presented to communities, at conferences and published in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT01735084.

Published
2020

40. Subcutaneous administration of benzathine benzylpenicillin G has favourable pharmacokinetic characteristics for the prevention of rheumatic heart disease compared with intramuscular injection: A randomized, crossover, population pharmacokinetic study in healthy adult volunteers

Author

Kado, J.H., Salman, S., Henderson, R., Hand, R., Wyber, R., Page-Sharp, Madhu, Batty, Kevin, Carapetis, J., Manning, L., Kado, J.H., Salman, S., Henderson, R., Hand, R., Wyber, R., Page-Sharp, Madhu, Batty, Kevin, Carapetis, J., and Manning, L.

Abstract

Background: Benzathine penicillin G has been used as monthly deep intramuscular (IM) injections since the 1950s for secondary prevention of acute rheumatic fever and rheumatic heart disease (RHD). Injection frequency and pain are major programmatic barriers for adherence, prompting calls for development of better long-Acting penicillin preparations to prevent RHD. We hypothesized that subcutaneous (SC) administration of benzathine penicillin G could delay penicillin absorption when compared with IMinjections. Methods: To compare the pharmacokinetic profile and tolerability of benzathine penicillin G according to different routes of administration, 15 healthy males participated in a randomized crossover study to receive benzathine penicillin G by either SC or IM routes, with a 10 week washout period before the second dose by the alternative route. Ultrasound guidance confirmed injection location. Penicillin concentrations and pain scores were measured for 6 weeks following injections. Results: SC administration was well tolerated with no significant differences in pain scores. Following SC injection, the principal absorption half-life (95% CI) was 20.1 (16.3-29.5) days and 89.6% (87.1%-92.0%) of the drug was directed via this pathway compared with 10.2 (8.6-12.5) days and 71.3% (64.9%-77.4%) following IM administration. Lower peak and higher trough penicillin concentrations resulted following SC injection. Simulations demonstrated that SC infusion of higher doses of benzathine penicillin G could provide therapeutic penicillin concentrations for 3months. Conclusions: SC administration of benzathine penicillin G is safe and significantly delays penicillin absorption. High-dose benzathine penicillin G via the SC route would fulfil many product characteristics required for the next generation of longer-Acting penicillins for use in RHD.

Published
2020

49. P3131Evolution of subclinical rheumatic heart disease: a multi-centre retrospective cohort study

Author

Sanyahumbi, A, primary, Karthikeyan, G, additional, Aliku, T, additional, Beaton, A, additional, Carapetis, J, additional, Culliford-Semmens, N, additional, Engelman, D, additional, Kado, J, additional, Maguire, G, additional, Okello, E, additional, Penny, D J, additional, Remond, M, additional, Sable, C A, additional, Steer, A, additional, and Wilson, N, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results