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1. COBALT: A Confirmatory Trial of Obeticholic Acid in Primary Biliary Cholangitis With Placebo and External Controls.

Author

Kowdley, Kris V, Hirschfield, Gideon M, Coombs, Charles, Malecha, Elizabeth S, Bessonova, Leona, Li, Jing, Rathnayaka, Nuvan, Mells, George, Jones, David E, Trivedi, Palak J, Hansen, Bettina E, Smith, Rachel, Wason, James, Hiu, Shaun, Kareithi, Dorcas N, Mason, Andrew L, Bowlus, Christopher L, Muller, Kate, Carbone, Marco, Berenguer, Marina, Milkiewicz, Piotr, Adekunle, Femi, and Villamil, Alejandra

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Chronic Liver Disease and Cirrhosis, Clinical Research, Rare Diseases, Digestive Diseases, Women's Health, Liver Disease, 6.1 Pharmaceuticals, Oral and gastrointestinal, Gastroenterology & Hepatology, Clinical sciences
Abstract

ObjectivesObeticholic acid (OCA) treatment for primary biliary cholangitis (PBC) was conditionally approved in the phase 3 POISE trial. The COBALT confirmatory trial assessed whether clinical outcomes in PBC patients improve with OCA therapy.MethodsPatients randomized to OCA (5-10 mg) were compared with placebo (randomized controlled trial [RCT]) or external control (EC). The primary composite endpoint was time to death, liver transplant, model for end-stage liver disease score ≥15, uncontrolled ascites, or hospitalization for hepatic decompensation. A prespecified propensity score-weighted EC group was derived from a US healthcare claims database.ResultsIn the RCT, the primary endpoint occurred in 28.6% of OCA (n=168) and 28.9% of placebo patients (n=166; intent-to-treat [ITT] analysis hazard ratio [HR]=1.01, 95% CI=0.68-1.51), but functional unblinding and crossover to commercial therapy occurred, especially in the placebo arm. Correcting for these using inverse probability of censoring weighting (IPCW) and as-treated analyses shifted the HR to favor OCA. In the EC (n=1051), the weighted primary endpoint occurred in 10.1% of OCA and 21.5% of non-OCA patients (HR=0.39; 95% CI=0.22-0.69; P=0.001). No new safety signals were identified in the RCT.ConclusionsFunctional unblinding and treatment crossover, particularly in the placebo arm, confounded the ITT estimate of outcomes associated with OCA in the RCT. Comparison with the real-world EC showed that OCA treatment significantly reduced the risk of negative clinical outcomes. These analyses demonstrate the value of EC data in confirmatory trials and suggest that treatment with OCA improves clinical outcomes in patients with PBC.

Published
2024

2. A Logical Interpretation of Asynchronous Multiparty Compatibility

Author

Carbone, Marco, Marin, Sonia, and Schürmann, Carsten

Subjects
Computer Science - Logic in Computer Science
Abstract

Session types are types for specifying the protocols that communicating processes must follow in a concurrent system. When composing two or more well-typed processes, a session typing system must check whether such processes are multiparty compatible, a property that guarantees that all sent messages are eventually received and no deadlock ever occurs. Previous work has shown that duality and the more general notion of coherence are sufficient syntactic conditions for guaranteeing the multiparty compatibility property. In this paper, following a propositions-as-types fashion which relates session types to linear logic, we generalise coherence to forwarders. Forwarders are processes that act as middleware by forwarding messages according to a given protocol. Our main result shows that forwarders not only generalise coherence, but fully capture all well-typed multiparty compatible processes., Comment: arXiv admin note: substantial text overlap with arXiv:2112.07636

Published
2023

4. The Concurrent Calculi Formalisation Benchmark

Author

Carbone, Marco, Castro-Perez, David, Ferreira, Francisco, Gheri, Lorenzo, Jacobsen, Frederik Krogsdal, Momigliano, Alberto, Padovani, Luca, Scalas, Alceste, Tirore, Dawit, Vassor, Martin, Yoshida, Nobuko, Zackon, Daniel, Hartmanis, Juris, Founding Editor, van Leeuwen, Jan, Series Editor, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Kobsa, Alfred, Series Editor, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Nierstrasz, Oscar, Series Editor, Pandu Rangan, C., Editorial Board Member, Sudan, Madhu, Series Editor, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Vardi, Moshe Y, Series Editor, Goos, Gerhard, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Castellani, Ilaria, editor, and Tiezzi, Francesco, editor

Published
2024
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5. A Probabilistic Choreography Language for PRISM

Author

Carbone, Marco, Veschetti, Adele, Hartmanis, Juris, Founding Editor, van Leeuwen, Jan, Series Editor, Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Kobsa, Alfred, Series Editor, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Nierstrasz, Oscar, Series Editor, Pandu Rangan, C., Editorial Board Member, Sudan, Madhu, Series Editor, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Vardi, Moshe Y, Series Editor, Goos, Gerhard, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Castellani, Ilaria, editor, and Tiezzi, Francesco, editor

Published
2024
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6. Proceedings of the 13th International Workshop on Programming Language Approaches to Concurrency and Communication-cEntric Software

Author

Carbone, Marco and Neykova, Rumyana

Subjects
Computer Science - Programming Languages, Computer Science - Distributed, Parallel, and Cluster Computing, Computer Science - Logic in Computer Science
Abstract

The increasingly concurrent and parallel landscape of hardware and software infrastructures demands the exploration and understanding of a wide variety of foundational and practical ideas. The International Workshop on Programming Language Approaches to Concurrency and Communication-cEntric Software (PLACES) is dedicated to work in this area. The workshop offers a forum for researchers from different fields to exchange new ideas about these challenges to modern and future programming, where concurrency and distribution are the norm rather than a marginal concern. The topic is central and combines well with the main conferences of ETAPS, in particular with ESOP.

Published
2022
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7. Latent class mixed modelling for phenotypic stratification of primary biliary cholangitis patients on first line treatment

Author

Mulcahy, Victoria, Rouanet, Anais, Gerussi, Alessio, Duckworth, Adam, Flack, Steve, Carbone, Marco, Tom, Brian, and Mells, George

Subjects
Statistics - Applications, 92C60
Abstract

In patients with primary biliary cholangitis (PBC), the serum liver biochemistry measured during treatment with ursodeoxycholic acid (the UDCA response) accurately predicts long-term outcome. In this study we sought to use liver biochemistry, and in particular alkaline phosphatase (ALP), as a surrogate marker of disease activity, for phenotypic stratification in PBC using a computational modelling approach. Our aim here was to identify distinct disease subgroups of patients with distinct disease trajectories. Methods: We used longitudinal ALP results from 1,601 PBC patients on first line treatment with UDCA, and applied latent class mixed modelling (LCMM), to identify distinct phenotypic subgroups, each with distinct disease trajectories, and risks of end stage liver disease (ESLD). Results: We identified four well discriminated phenotypic subgroups within our PBC cohort, each with distinct disease trajectories., Comment: 17 pages, 5 figures, 10 tables

Published
2022

8. Loss of biochemical response at any time worsens outcomes in UDCA-treated patients with primary biliary cholangitis

Author

Roberts, Surain B., Choi, Woo Jin, Worobetz, Lawrence, Vincent, Catherine, Flemming, Jennifer A., Cheung, Angela, Qumosani, Karim, Swain, Mark, Grbic, Dusanka, Ko, Hin Hin, Peltekian, Kevork M., Abrahamyan, Lusine, Saini, Monika, Tirona, Kattleya, Aziz, Bishoi, Lytvyak, Ellina, Invernizzi, Pietro, Ponsioen, Cyriel Y., Bruns, Tony, Cazzagon, Nora, Lindor, Keith, Dalekos, George N., Gatselis, Nikolaos K., Verhelst, Xavier, Floreani, Annarosa, Corpechot, Christophe, Mayo, Marlyn J., Levy, Cynthia, Londoño, Maria-Carlota, Battezzati, Pier M., Pares, Albert, Nevens, Frederik, van der Meer, Adriaan, Kowdley, Kris V., Trivedi, Palak J., Lleo, Ana, Thorburn, Douglas, Carbone, Marco, Selzner, Nazia, Gulamhusein, Aliya F., Janssen, Harry LA., Montano-Loza, Aldo J., Mason, Andrew L., Hirschfield, Gideon M., and Hansen, Bettina E.

Published
2024
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9. Prognostic scores for ursodeoxycholic acid-treated patients predict graft loss and mortality in recurrent primary biliary cholangitis after liver transplantation

Author

Montano-Loza, Aldo J., Lytvyak, Ellina, Hirschfield, Gideon, Hansen, Bettina E., Ebadi, Maryam, Berney, Thierry, Toso, Christian, Magini, Giulia, Villamil, Alejandra, Nevens, Frederik, Van den Ende, Natalie, Pares, Albert, Ruiz, Pablo, Terrabuio, Débora, Trivedi, Palak J., Abbas, Nadir, Donato, Maria Francesca, Yu, Lei, Landis, Charles, Dumortier, Jérôme, Dyson, Jessica Katharine, van der Meer, Adriaan J., de Veer, Rozanne, Pedersen, Mark, Mayo, Marlyn, Manns, Michael P., Taubert, Richard, Kirchner, Theresa, Belli, Luca S., Mazzarelli, Chiara, Stirnimann, Guido, Floreani, Annarosa, Cazzagon, Nora, Russo, Francesco Paolo, Burra, Patrizia, Zigmound, Udi, Houri, Inbal, Carbone, Marco, Mulinacci, Giacomo, Fagiuoli, Stefano, Pratt, Daniel Stephan, Bonder, Alan, Schiano, Thomas D., Haydel, Brandy, Lohse, Ansgar, Schramm, Christoph, Rüther, Darius, Casu, Stefania, Verhelst, Xavier, Beretta-Piccoli, Benedetta Terziroli, Robles, Mercedes, Mason, Andrew L., and Corpechot, Christophe

Published
2024
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10. Intensive care management of acute-on-chronic liver failure

Author

Perricone, Giovanni, Artzner, Thierry, De Martin, Eleonora, Jalan, Rajiv, Wendon, Julia, and Carbone, Marco

Subjects
Transplantation of organs, tissues, etc. -- Health aspects, Strategic planning (Business) -- Health aspects, Mortality -- United Kingdom -- Canada, Liver failure -- Health aspects, Liver cirrhosis -- Health aspects, Company business management, Health care industry
Abstract

Acute-on-chronic liver failure (ACLF) is a clinical syndrome defined by an acute deterioration of the liver function associated with extrahepatic organ failures requiring intensive care support and associated with a high short-term mortality. ACLF has emerged as a major cause of mortality in patients with cirrhosis and chronic liver disease. ACLF has a unique pathophysiology in which systemic inflammation plays a key role; this provides the basis of novel therapies, several of which are now in clinical trials. Intensive care unit (ICU) therapy parallels that applied in the general ICU population in some organ failures but has peculiar differential characteristics in others. Critical care management strategies and the option of liver transplantation (LT) should be balanced with futility considerations in those with a poor prognosis. Nowadays, LT is the only life-saving treatment that can radically improve the long-term prognosis of patients with ACLF. This narrative review will provide insights on the current understanding of ACLF with emphasis on intensive care management., Author(s): Giovanni Perricone [sup.1], Thierry Artzner [sup.2], Eleonora De Martin [sup.3], Rajiv Jalan [sup.4] [sup.5], Julia Wendon [sup.6], Marco Carbone [sup.7] [sup.8] Author Affiliations: (1) Hepatology and Gastroenterology Unit, ASST [...]

Published
2023
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11. Forwarders as Process Compatibility, Logically

Author

Carbone, Marco, Marin, Sonia, and Schürmann, Carsten

Subjects
Computer Science - Programming Languages, Computer Science - Logic in Computer Science
Abstract

Session types define protocols that processes must follow when communicating. The special case of binary session types, i.e. type annotations of protocols between two parties, is known to be in a propositions-as-types correspondence with linear logic. In previous work, we have shown that the generalization to multiparty session types can be expressed either by coherence proofs or by arbiters, processes that act as middleware by forwarding messages according to the given protocol. In this paper, following the propositions-as-types fashion, we generalize arbiters to a logic, which we call forwarder logic, a fragment of classical linear logic still satisfying cut-elimination. Our main result is summarized as follows: forwarders generalize coherence and give an elegant proof-theoretic characterization of multiparty compatibility, a property of concurrent systems guaranteeing that all sent messages are eventually received and no deadlock ever occurs.

Published
2021

13. Synchronous Forwarders

Author

Carbone, Marco, Marin, Sonia, and Schürmann, Carsten

Subjects
Computer Science - Programming Languages, Computer Science - Logic in Computer Science
Abstract

Session types are types for specifying protocols that processes must follow when communicating with each other. Session types are in a propositions-as-types correspondence with linear logic. Previous work has shown that a multiparty session type, a generalisation of session types to protocols of two or more parties, can be modelled as a proof of coherence, a generalisation of linear logic duality. And, protocols expressed as coherence can be simulated by arbiters, processes that act as a middleware by forwarding messages according to the given protocol. In this paper, we generalise the concept of arbiter to that of synchronous forwarder, that is a processes that implements the behaviour of an arbiter in several different ways. In a propositions-as-types fashion, synchronous forwarders form a logic equipped with cut elimination which is a special restriction of classical linear logic. Our main result shows that synchronous forwarders are a characterisation of coherence, i.e., coherence proofs can be transformed into synchronous forwarders and, viceversa, every synchronous forwarder corresponds to a coherence proofs.

Published
2021

14. Deep Learning helps discriminating Autoimmune Hepatitis and Primary Biliary Cholangitis

Author

Gerussi, Alessio, Saldanha, Oliver Lester, Cazzaniga, Giorgio, Verda, Damiano, Carrero, Zunamys I., Engel, Bastian, Taubert, Richard, Bolis, Francesca, Cristoferi, Laura, Malinverno, Federica, Colapietro, Francesca, Akpinar, Reha, Di Tommaso, Luca, Terracciano, Luigi, Lleo, Ana, Viganó, Mauro, Rigamonti, Cristina, Cabibi, Daniela, Calvaruso, Vincenza, Gibilisco, Fabio, Caldonazzi, Nicoló, Valentino, Alessandro, Ceola, Stefano, Canini, Valentina, Nofit, Eugenia, Muselli, Marco, Calderaro, Julien, Tiniakos, Dina, L’Imperio, Vincenzo, Pagni, Fabio, Zucchini, Nicola, Invernizzi, Pietro, Carbone, Marco, and Kather, Jakob Nikolas

Published
2024
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15. Dynamics of Liver Stiffness Measurement and Clinical Course of Primary Biliary Cholangitis

Author

Lam, Laurent, Soret, Pierre-Antoine, Lemoinne, Sara, Hansen, Bettina, Hirschfield, Gideon, Gulamhusein, Aliya, Montano-Loza, Aldo J., Lytvyak, Ellina, Parés, Albert, Olivas, Ignasi, Londono, Maria-Carlota, Rodríguez-Tajes, Sergio, Eaton, John E., Osman, Karim T., Schramm, Christoph, Sebode, Marcial, Lohse, Ansgar W., Dalekos, George, Gatselis, Nikolaos, Nevens, Frederik, Cazzagon, Nora, Zago, Alessandra, Russo, Francesco Paolo, Floreani, Annarosa, Abbas, Nadir, Trivedi, Palak, Thorburn, Douglas, Saffioti, Francesca, Barkai, Laszlo, Roccarina, Davide, Calvaruso, Vicenza, Fichera, Anna, Delamarre, Adèle, Sobenko, Natalia, Villamil, Alejandra Maria, Medina-Morales, Esli, Bonder, Alan, Patwardhan, Vilas, Rigamonti, Cristina, Carbone, Marco, Invernizzi, Pietro, Cristoferi, Laura, van der Meer, Adriaan, de Veer, Rozanne, Zigmond, Ehud, Yehezkel, Eyal, Kremer, Andreas E., Deibel, Ansgar, Bruns, Tony, Große, Karsten, Wetten, Aaron, Dyson, Jessica Katharine, Jones, David, Levy, Cynthia, Tanaka, Atsushi, Dumortier, Jérôme, Pageaux, Georges-Philippe, de Lédinghen, Victor, Carrat, Fabrice, Chazouillères, Olivier, and Corpechot, Christophe

Published
2024
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17. Development and Validation of a Scoring System to Predict Response to Obeticholic Acid in Primary Biliary Cholangitis

Author

Scaravaglio, Miki, Nofit, Eugenia, Gallo, Paolo, Galati, Giovanni, Pezzato, Francesco, Rollo, Paolo, D’Ovidio, Erica, Coco, Barbara, Tortora, Annalisa, Fiorini, Cecilia, Venere, Rosanna, Scifo, Gaetano, Cannavò, Mariarita, Feletti, Valentina, Pizzolante, Fabrizio, Giannini, Edoardo Giovanni, Cotugno, Rosa, Fanella, Silvia, Losito, Francesco, Grassi, Giuseppe, Manfredi, Giulia Francesca, Buzzanca, Valerio, Omazzi, Barbara, Casella, Silvia, Zani, Francesca, Ricci, Chiara, Bellia, Valentina, Abenavoli, Ludovico, Morelli, Olivia, Crocè, Lory Saveria, Scivetti, Paolo, Panero, Antonio, Boano, Valentina, Poggi, Guido, Gimignani, Giancarlo, Conforti, Alessandro, Frazzetto, Evelise, Rapisarda, Laura, Demma, Shrin, De Vincentis, Antonio, Ampuero, Javier, Terracciani, Francesca, D’Amato, Daphne, Gerussi, Alessio, Cristoferi, Laura, Cazzagon, Nora, Bonaiuto, Emanuela, Floreani, Annarosa, Calvaruso, Vincenza, Cadamuro, Luca, Degasperi, Elisabetta, Morgando, Anna, Vanni, Ester, Lleo, Ana, Colapietro, Francesca, Alvaro, Domenico, Castellaneta, Antonino, Labanca, Sara, Viganò, Mauro, Distefano, Marco, Pace Palitti, Valeria, De Matthaeis, Nicoletta, Marzioni, Marco, Gómez-Dominguez, Elena, Montero, Jose-Luis, Molina, Esther, Garcia-Buey, Luisa, Casado, Marta, Berenguer, Marina, Conde, Isabel, Simon, Miguel-Angel, Fuentes, Javier, Costa-Moreira, Pedro, Macedo, Guilherme, Jorquera, Francisco, Morillas, Rosa-Maria, Presa, Jose, Sousa, Jose-Manuel, Gomes, Dario, Santos, Luis, Olveira, Antonio, Hernandez-Guerra, Manuel, Aburruza, Leire, Santos, Arsenio, Carvalho, Armando, Uriz, Juan, Gutierrez, Maria-Luisa, Perez, Elia, Chessa, Luchino, Pellicelli, Adriano, Marignani, Massimo, Muratori, Luigi, Niro, Grazia Anna, Brunetto, Maurizia, Ponziani, Francesca Romana, Pompili, Maurizio, Marra, Fabio, Galli, Andrea, Mussetto, Alessandro, Alagna, Giuliano, Simone, Loredana, Bertino, Gaetano, Rosina, Floriano, Cozzolongo, Raffaele, Russello, Maurizio, Baiocchi, Leonardo, Saitta, Carlo, Terreni, Natalia, Zolfino, Teresa, Rigamonti, Cristina, Vigano, Raffaella, Cuccorese, Giuseppe, Pozzoni, Pietro, Pedone, Claudio, Grasso, Simone, Picardi, Antonio, Invernizzi, Pietro, Sacco, Rodolfo, Izzi, Antonio, Fernandez-Rodriguez, Conrado, Vespasiani-Gentilucci, Umberto, and Carbone, Marco

Published
2024
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19. Artificial Intelligence and liver: Opportunities and barriers

Author

Brunetto, Maurizia Rossana, Bonino, Ferruccio, Montalti, Roberto, Campanile, Silvia, Persico, Marcello, Alvaro, Domenico, Santini, Silvano, Jr., Invernizzi, Pietro, Carbone, Marco, Masarone, Mario, Eccher, Albino, Siciliano, Bruno, Vento, Mario, Ficuciello, Fanny, Cabitza, Federico, Penasa, Simone, Donatelli, Piergiorgio, Balsano, Clara, Burra, Patrizia, Duvoux, Christophe, Alisi, Anna, Piscaglia, Fabio, and Gerussi, Alessio

Published
2023
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21. A Sound Algorithm for Asynchronous Session Subtyping and its Implementation

Author

Bravetti, Mario, Carbone, Marco, Lange, Julien, Yoshida, Nobuko, and Zavattaro, Gianluigi

Subjects
Computer Science - Programming Languages
Abstract

Session types, types for structuring communication between endpoints in distributed systems, are recently being integrated into mainstream programming languages. In practice, a very important notion for dealing with such types is that of subtyping, since it allows for typing larger classes of system, where a program has not precisely the expected behaviour but a similar one. Unfortunately, recent work has shown that subtyping for session types in an asynchronous setting is undecidable. To cope with this negative result, the only approaches we are aware of either restrict the syntax of session types or limit communication (by considering forms of bounded asynchrony). Both approaches are too restrictive in practice, hence we proceed differently by presenting an algorithm for checking subtyping which is sound, but not complete (in some cases it terminates without returning a decisive verdict). The algorithm is based on a tree representation of the coinductive definition of asynchronous subtyping; this tree could be infinite, and the algorithm checks for the presence of finite witnesses of infinite successful subtrees. Furthermore, we provide a tool that implements our algorithm. We use this tool to test our algorithm on many examples that cannot be managed with the previous approaches, and to provide an empirical evaluation of the time and space cost of the algorithm., Comment: This is an extended version of the CONCUR'19 version

Published
2019
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24. Study Typology: An Overview

Author

Mulinacci, Giacomo, Carbone, Marco, Coccolini, Federico, Series Editor, Coimbra, Raul, Series Editor, Kirkpatrick, Andrew W., Series Editor, Di Saverio, Salomone, Series Editor, Ansaloni, Luca, Editorial Board Member, Balogh, Zsolt, Editorial Board Member, Biffl, Walt, Editorial Board Member, Catena, Fausto, Editorial Board Member, Davis, Kimberly, Editorial Board Member, Ferrada, Paula, Editorial Board Member, Fraga, Gustavo, Editorial Board Member, Ivatury, Rao, Editorial Board Member, Kluger, Yoram, Editorial Board Member, Leppaniemi, Ari, Editorial Board Member, Maier, Ron, Editorial Board Member, Moore, Ernest E., Editorial Board Member, Napolitano, Lena, Editorial Board Member, Peitzman, Andrew, Editorial Board Member, Reilly, Patrick, Editorial Board Member, Rizoli, Sandro, Editorial Board Member, Sakakushev, Boris E., Editorial Board Member, Sartelli, Massimo, Editorial Board Member, Scalea, Thomas, Editorial Board Member, Spain, David, Editorial Board Member, Stahel, Philip, Editorial Board Member, Sugrue, Michael, Editorial Board Member, Velmahos, George, Editorial Board Member, Weber, Dieter, Editorial Board Member, Ceresoli, Marco, editor, Abu-Zidan, Fikri M., editor, and Staudenmayer, Kristan L., editor

Published
2022
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25. THU-125 Key questions that patients with primary biliary cholangitis should ask their physician -Delphi method-

Author

Werner, Ellen, primary, van Hooff, Maria C., additional, Abbas, Nadir, additional, Gerussi, Alessio, additional, Willemse, José A., additional, Mitchell-Thain, Robert, additional, Leburgue, Angela, additional, Hirschfield, Gideon M., additional, Corpechot, Christophe, additional, Schramm, Christoph, additional, Levy, Cynthia, additional, Nevens, Frederik, additional, Verbeek, Jef, additional, Mason, Andrew L., additional, Dalekos, George, additional, Cazzagon, Nora, additional, Mells, George F., additional, Kowdley, Kris V., additional, Carbone, Marco, additional, Jones, David E., additional, Hansen, Bettina E., additional, Trivedi, Palak J., additional, and van der Meer, Adriaan J., additional

Published
2024
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26. THU-161 Hepatic sarcoidosis diagnosis and management: an italian multicenter study

Author

Corte, Cristina Della, primary, D'Amato, Daphne, additional, Rocchetti, Adele, additional, Viganò, Mauro, additional, Martini, Andrea, additional, Morelli, Maria Cristina, additional, Terracciani, Francesca, additional, Campigotto, Michele, additional, Pugliese, Nicola, additional, Giannini, Edoardo, additional, Simone, Loredana, additional, Malinverno, Federica, additional, Reati, Raffaella, additional, Degasperi, Elisabetta, additional, Federico, Alessandro, additional, Mangoni, Emanuele Durante, additional, Missale, Gabriele, additional, Svegliati-Baroni, Gianluca, additional, Morana, Ester, additional, Rapetti, Rachele, additional, Lorenzo, Surace, additional, Arena, Ilaria, additional, Cespiati, Annalisa, additional, Del Poggio, Paolo, additional, Germani, Giacomo, additional, Marin, Renato, additional, Federica, Mirici, additional, Rosaria, Piras Maria, additional, Perricone, Giovanni, additional, Sciarrone, Salvatore, additional, Rendina, Maria Grazia, additional, Strona, Silvia, additional, Giampaolo, Luca, additional, Montagnese, Sara, additional, Saibeni, Simone, additional, Manes, Giampiero, additional, and Carbone, Marco, additional

Published
2024
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27. THU-101 Non-invasive tests for ruling out high-risk esophageal varices in patients with primary biliary cholangitis based on the cholestasis degree

Author

Calvaruso, Vincenza, primary, Celsa, Ciro, additional, Cristoferi, Laura, additional, Scaravaglio, Miki, additional, Nofit, Eugenia, additional, Smith, Rachel, additional, Kaur, Senamjit, additional, Di Maria, Gabriele, additional, Capodicasa, Luigi, additional, Cadamuro, Luca, additional, Gerussi, Alessio, additional, Malinverno, Federica, additional, Lampertico, Pietro, additional, Cazzagon, Nora, additional, Marzioni, Marco, additional, Vespasiani-Gentilucci, Umberto, additional, Colapietro, Francesca, additional, Andreone, Pietro, additional, Lleo, Ana, additional, Rigamonti, Cristina, additional, Viganò, Mauro, additional, Giannini, Edoardo, additional, Russello, Maurizio, additional, Vanni, Ester, additional, Cerini, Federica, additional, Orlandini, Alessandra, additional, Brunetto, Maurizia, additional, Niro, Grazia Anna, additional, Vettori, Giovanni, additional, Castellaneta, Antonino, additional, Cardinale, Vincenzo, additional, Alvaro, Domenico, additional, Mega, Andrea, additional, Palitti, Valeria Pace, additional, Bellanti, Francesco, additional, Marco, Vito Di, additional, Mells, George, additional, Culver, Emma, additional, Invernizzi, Pietro, additional, Camma, Calogero, additional, and Carbone, Marco, additional

Published
2024
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28. THU-102-YI Specific glycomic profiles can identify patients at risk of poor transplant-free survival in primary biliary cholangitis

Author

Somers, Nicky, primary, Gatselis, Nikolaos, additional, van Hooff, Maria C., additional, Lygoura, Vasiliki, additional, Butaye, Emma, additional, Grossar, Lorenz, additional, Raevens, Sarah, additional, Geerts, Anja, additional, Lefere, Sander, additional, Devisscher, Lindsey, additional, Meuris, Leander, additional, Carbone, Marco, additional, Trivedi, Palak, additional, Londoño, María Carlota, additional, Levy, Cynthia, additional, Tanaka, Atsushi, additional, Hirschfield, Gideon M., additional, Corpechot, Christophe, additional, Callewaert, Nico, additional, Van Vlierberghe, Hans, additional, van der Meer, Adriaan J., additional, Dalekos, George, additional, Hansen, Bettina E., additional, and Verhelst, Xavier, additional

Published
2024
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29. LBP-038 Expanding knowledge regarding real-world treatment of patients with primary biliary cholangitis with obeticholic acid from the Italian RECAPITULATE cohort

Author

Terracciani, Francesca, primary, De Vincentis, Antonio, additional, D'Amato, Daphne, additional, Scaravaglio, Miki, additional, Invernizzi, Pietro, additional, Vanni, Ester, additional, Campion, Daniela, additional, Floreani, Annarosa, additional, Cazzagon, Nora, additional, Alvaro, Domenico, additional, Venere, Rosanna, additional, Giannini, Edoardo, additional, Labanca, Sara, additional, Lleo, Ana, additional, Colapietro, Francesca, additional, Degasperi, Elisabetta, additional, Vigano, Mauro, additional, Pesatori, Eugenia Vittoria, additional, Fagiuoli, Stefano, additional, Marzioni, Marco, additional, Buzzanca, Valerio, additional, Vigano, Raffaella, additional, D'Amico, Federico, additional, Galli, Andrea, additional, Curto, Armando, additional, Marra, Fabio, additional, Begini, Paola, additional, Baiocchi, Leonardo, additional, Carni, Paola, additional, Muratori, Luigi, additional, Coco, Barbara, additional, Brunetto, Maurizia, additional, Pizzolante, Fabrizio, additional, De Matthaeis, Nicoletta, additional, Falbo, Elisabetta, additional, Surace, Lorenzo, additional, Mattalia, Alberto, additional, Ieluzzi, Donatella, additional, Salomone, Federico, additional, Monache, Guido Delle, additional, Tatonetti, Riccardo, additional, Cavalli, Ilaria, additional, Cossiga, Valentina, additional, Morisco, Filomena, additional, Valiani, Vincenzo, additional, Gatti, Pietro, additional, Boccaccio, Vincenzo, additional, Angrisani, Debora, additional, Vettori, Giovanni, additional, Cuffari, Biagio, additional, Moretti, Alessandra, additional, Nardone, Gerardo, additional, Rocco, Alba, additional, Scivetti, Paolo, additional, Costanzo, Martina, additional, Boano, Valentina, additional, Manfredi, Giulia Francesca, additional, Simone, Loredana, additional, Palitti, Valeria Pace, additional, Russello, Maurizio, additional, Cannavo, Maria Rita, additional, Frazzetto, Evelise, additional, Bertino, Gaetano, additional, Distefano, Marco, additional, Izzi, Antonio, additional, Cerini, Federica, additional, Chessa, Luchino, additional, Miglianti, Michela, additional, Feletti, Valentina, additional, Mussetto, Alessandro, additional, Cozzolongo, Raffaele, additional, Losito, Francesco, additional, Niro, Grazia Anna, additional, Cotugno, Rosa, additional, Sacco, Rodolfo, additional, Ricci, Chiara, additional, Poisa, Paolo, additional, Cadamuro, Luca, additional, Castellaneta, Antonino, additional, Squeo, Francesco, additional, Terreni, Natalia, additional, Bina, Niccolo, additional, Pozzoni, Pietro, additional, Casella, Silvia, additional, Zani, Francesca, additional, Morelli, Olivia, additional, Cuccorese, Giuseppe, additional, Saitta, Carlo, additional, Zolfino, Teresa, additional, Rigamonti, Cristina, additional, Calvaruso, Vincenza, additional, Carbone, Marco, additional, and Vespasiani-Gentilucci, Umberto, additional

Published
2024
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30. GS-007 Prospective validation of the prognostic value of liver stiffness assessed by Fibroscan in primary sclerosing cholangitis: final results of the FICUS study

Author

Chazouillères, Olivier, primary, Schramm, Christoph, additional, Trivedi, Palak J., additional, Bellet, Jonathan, additional, du Sorbier, Aymeric Monegier, additional, Thorburn, Douglas, additional, Färkkilä, Martti, additional, Floreani, Annarosa, additional, Pares, Albert, additional, Levy, Cynthia, additional, Beuers, Ulrich, additional, Ytting, Henriette, additional, Zigmond, Ehud, additional, Eksteen, Bertus, additional, Invernizzi, Pietro, additional, Lemoinne, Sara, additional, Lohse, Ansgar W., additional, Hirschfield, Gideon M., additional, Cazzagon, Nora, additional, Llovet, Llaura, additional, Ponsioen, Cyriel, additional, Carbone, Marco, additional, Katja, Füssel, additional, Pezzato, Francesco, additional, Patel, Isha, additional, Helder, Jeltje, additional, Khan, Sheeba, additional, Belkacem, Karima Ben, additional, Farid, Gaouar, additional, Housset, Chantal, additional, Carrat, Fabrice, additional, and Corpechot, Christophe, additional

Published
2024
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31. OS-017 Deep learning discriminates autoimmune hepatitis and primary biliary cholangitis

Author

Gerussi, Alessio, primary, Saldanha, Oliver, additional, Cazzaniga, Giorgio, additional, Verda, Damiano, additional, Carrero, Zunamys, additional, Engel, Bastian, additional, Taubert, Richard, additional, Bolis, Francesca, additional, Cristoferi, Laura, additional, Malinverno, Federica, additional, Colapietro, Francesca, additional, Akpinar, Reha, additional, Di Tommaso, Luca, additional, Terracciano, Luigi, additional, Lleo, Ana, additional, Viganò, Mauro, additional, Rigamonti, Cristina, additional, Cabibi, Daniela, additional, Calvaruso, Vincenza, additional, Gibilisco, Fabio, additional, Caldonazzi, Nicoló, additional, Valentino, Alessandro, additional, Ceola, Stefano, additional, Canini, Valentina, additional, Nofit, Eugenia, additional, Muselli, Marco, additional, Calderaro, Julien, additional, Tiniakos, Dina, additional, L'Imperio, Vincenzo, additional, Pagni, Fabio, additional, Zucchini, Nicola, additional, Invernizzi, Pietro, additional, Carbone, Marco, additional, and Kather, Jakob Nikolas, additional

Published
2024
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32. THU-167 Diagnostic and therapeutic trends in primary biliary cholangitis: insights from the european reference network registry (R-LIVER)

Author

Gerussi, Alessio, primary, Bernasconi, Davide, additional, Kroll, Claudia, additional, Groß, Finja, additional, Schregel, Ida, additional, Marini, Alberto, additional, Cristoferi, Laura, additional, Papp, Maria, additional, Dalekos, George, additional, Rigopoulou, Eirini, additional, Gatselis, Nikolaos, additional, Janik, Maciej, additional, Milkiewicz, Piotr, additional, Kruk, Beata, additional, Villamil, Alejandra, additional, Ytting, Henriette, additional, Di Bartolomeo, Claudia, additional, Terziroli, Benedetta, additional, Jirsa, Milan, additional, Zigmond, Ehud, additional, Sebode, Marcial, additional, Lohse, Ansgar W., additional, Hansen, Bettina E., additional, Carbone, Marco, additional, Schramm, Christoph, additional, and Invernizzi, Pietro, additional

Published
2024
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33. THU-133-YI Radiomics for prognostication in primary sclerosing cholangitis: a proof-of-concept using GLRLM run entropy

Author

Cristoferi, Laura, primary, Maino, Cesare, additional, Bernasconi, Davide, additional, Savino, Alberto, additional, Ripamonti, Ilaria, additional, Scaravaglio, Miki, additional, Pesatori, Eugenia Vittoria, additional, D'Amato, Daphne, additional, Gerussi, Alessio, additional, Alberzoni, Chiara, additional, Valsecchi, Maria Grazie, additional, Corso, Rocco, additional, Ippolito, Davide, additional, Invernizzi, Pietro, additional, De Bernardi, Elisabetta, additional, and Carbone, Marco, additional

Published
2024
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35. THU-098 Appraising gain of an extended 2-year placebo-controlled trial in primary biliary cholangitis: challenges for evaluating clinical outcomes

Author

Hansen, Bettina E., primary, Hirschfield, Gideon M., additional, Perez, Carla Fiorella Murillo, additional, McWherter, Charles A., additional, Dickinson, Klara, additional, Mason, Andrew L., additional, Montano-Loza, Aldo J, additional, Lytvyak, Ellina, additional, Dalekos, George, additional, Gatselis, Nikolaos, additional, Nevens, Frederik, additional, Cazzagon, Nora, additional, Levy, Cynthia, additional, Abbas, Nadir, additional, Trivedi, Palak, additional, Thorburn, Douglas, additional, Bonder, Alan, additional, Patwardhan, Vilas, additional, Londoño, María Carlota, additional, Carbone, Marco, additional, Cristoferi, Laura, additional, van der Meer, Adriaan J., additional, de Veer, Rozanne C., additional, Tanaka, Atsushi, additional, Janssen, Harry L.A., additional, Zigmond, Ehud, additional, Yehezkel, Eyal, additional, Kremer, Andreas E., additional, Deibel, Ansgar, additional, Bruns, Tony, additional, Große, Karsten, additional, Kowdley, Kris V., additional, Lleo, Ana, additional, Mayo, Marlyn J., additional, Verhelst, Xavier, additional, and Corpechot, Christophe, additional

Published
2024
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36. THU-093 Biochemical response and liver stiffness variation over time predict liver-related events in patients with primary biliary cholangitis treated with Obeticholic acid

Author

Vincentis, Antonio De, primary, Terracciani, Francesca, additional, D'Amato, Daphne, additional, Scaravaglio, Miki, additional, Invernizzi, Pietro, additional, Vanni, Ester, additional, Campion, Daniela, additional, Floreani, Annarosa, additional, Cazzagon, Nora, additional, Alvaro, Domenico, additional, Venere, Rosanna, additional, Giannini, Edoardo, additional, Labanca, Sara, additional, Lleo, Ana, additional, Colapietro, Francesca, additional, Degasperi, Elisabetta, additional, Viganò, Mauro, additional, Pesatori, Eugenia Vittoria, additional, Fagiuoli, Stefano, additional, Marzioni, Marco, additional, Buzzanca, Valerio, additional, Viganò, Raffaella, additional, D'Amico, Federico, additional, Galli, Andrea, additional, Curto, Armando, additional, Marra, Fabio, additional, Begini, Paola, additional, Baiocchi, Leonardo, additional, Carnì, Paola, additional, Muratori, Luigi, additional, Coco, Barbara, additional, Brunetto, Maurizia, additional, Pizzolante, Fabrizio, additional, Matthaeis, Nicoletta De, additional, Falbo, Elisabetta, additional, Surace, Lorenzo, additional, Mattalia, Alberto, additional, Ieluzzi, Donatella, additional, Salomone, Federico, additional, Monache, Guido Delle, additional, Tatonetti, Riccardo, additional, Cavalli, Ilaria, additional, Cossiga, Valentina, additional, Morisco, Filomena, additional, Valiani, Vincenzo, additional, Gatti, Pietro, additional, Boccaccio, Vincenzo, additional, Angrisani, Debora, additional, Vettori, Giovanni, additional, Cuffari, Biagio, additional, Moretti, Alessandra, additional, Rocco, Alba, additional, Nardone, Gerardo, additional, Scivetti, Paolo, additional, Costanzo, Martina, additional, Boano, Valentina, additional, Manfredi, Giulia Francesca, additional, Simone, Loredana, additional, Palitti, Valeria Pace, additional, Russello, Maurizio, additional, Cannavò, Maria Rita, additional, Frazzetto, Evelise, additional, Bertino, Gaetano, additional, Distefano, Marco, additional, Izzi, Antonio, additional, Cerini, Federica, additional, Chessa, Luchino, additional, Miglianti, Michela, additional, Feletti, Valentina, additional, Mussetto, Alessandro, additional, Cozzolongo, Raffaele, additional, Losito, Francesco, additional, Niro, Grazia Anna, additional, Cotugno, Rosa, additional, Sacco, Rodolfo, additional, Ricci, Chiara, additional, Poisa, Paolo, additional, Cadamuro, Luca, additional, Castellaneta, Antonino, additional, Squeo, Francesco, additional, Terreni, Natalia, additional, Bina, Niccolò, additional, Pozzoni, Pietro, additional, Casella, Silvia, additional, Zani, Francesca, additional, Morelli, Olivia, additional, Cuccorese, Giuseppe, additional, Saitta, Carlo, additional, Zolfino, Teresa, additional, Rigamonti, Cristina, additional, Calvaruso, Vincenza, additional, Carbone, Marco, additional, and Vespasiani-Gentilucci, Umberto, additional

Published
2024
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38. Development and validation of a scoring system to predict response to obeticholic acid in primary biliary cholangitis.

Author

De Vincentis, Antonio, primary, Ampuero, Javier, additional, Terracciani, Francesca, additional, D’Amato, Daphne, additional, Gerussi, Alessio, additional, Cristoferi, Laura, additional, Cazzagon, Nora, additional, Bonaiuto, Emanuela, additional, Floreani, Annarosa, additional, Calvaruso, Vincenza, additional, Cadamuro, Luca, additional, Degasperi, Elisabetta, additional, Morgando, Anna, additional, Vanni, Ester, additional, Lleo, Ana, additional, Colapietro, Francesca, additional, Alvaro, Domenico, additional, Castellaneta, Antonino, additional, Labanca, Sara, additional, Viganò, Mauro, additional, Distefano, Marco, additional, Palitti, Valeria Pace, additional, Ricci, Chiara, additional, De Matthaeis, Nicoletta, additional, Marzioni, Marco, additional, Gómez-Dominguez, Elena, additional, Montero, Jose-Luis, additional, Molina, Esther, additional, Garcia-Buey, Luisa, additional, Casado, Marta, additional, Berenguer, Marina, additional, Conde, Isabel, additional, Simon, Miguel-Angel, additional, Fuentes, Javier, additional, Costa-Moreira, Pedro, additional, Macedo, Guilherme, additional, Jorquera, Francisco, additional, Morillas, Rosa-Maria, additional, Presa, Jose, additional, Sousa, Jose-Manuel, additional, Gomes, Dario, additional, Santos, Luis, additional, Olveira, Antonio, additional, Hernandez-Guerra, Manuel, additional, Aburruza, Leire, additional, Santos, Arsenio, additional, Carvalho, Armando, additional, Uriz, Juan, additional, Gutierrez, Maria-Luisa, additional, Perez, Elia, additional, Chessa, Luchino, additional, Pellicelli, Adriano, additional, Marignani, Massimo, additional, Muratori, Luigi, additional, Niro, Grazia Anna, additional, Brunetto, Maurizia, additional, Ponziani, Francesca Romana, additional, Pompili, Maurizio, additional, Marra, Fabio, additional, Galli, Andrea, additional, Mussetto, Alessandro, additional, Alagna, Giuliano, additional, Simone, Loredana, additional, Bertino, Gaetano, additional, Rosina, Floriano, additional, Cozzolongo, Raffaele, additional, Russello, Maurizio, additional, Baiocchi, Leonardo, additional, Saitta, Carlo, additional, Terreni, Natalia, additional, Zolfino, Teresa, additional, Rigamonti, Cristina, additional, Vigano, Raffaella, additional, Cuccorese, Giuseppe, additional, Pozzoni, Pietro, additional, Pedone, Claudio, additional, Grasso, Simone, additional, Picardi, Antonio, additional, Invernizzi, Pietro, additional, Sacco, Rodolfo, additional, Izzi, Antonio, additional, Fernandez-Rodriguez, Conrado, additional, Vespasiani-Gentilucci, Umberto, additional, and Carbone, Marco, additional

Published
2024
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39. Multiparty Classical Choreographies

Author

Carbone, Marco, Cruz-Filipe, Luis, Montesi, Fabrizio, and Murawska, Agata

Subjects
Computer Science - Programming Languages, Computer Science - Logic in Computer Science
Abstract

We present Multiparty Classical Choreographies (MCC), a language model where global descriptions of communicating systems (choreographies) implement typed multiparty sessions. Typing is achieved by generalising classical linear logic to judgements that explicitly record parallelism by means of hypersequents. Our approach unifies different lines of work on choreographies and processes with multiparty sessions, as well as their connection to linear logic. Thus, results developed in one context are carried over to the others. Key novelties of MCC include support for server invocation in choreographies, as well as logic-driven compilation of choreographies with replicated processes., Comment: Post-proceedings paper presented at the 28th International Symposium on Logic-Based Program Synthesis and Transformation (LOPSTR 2018), Frankfurt am Main, Germany, 4-6 September 2018 (arXiv:1808.03326) The paper was improved and extended (+2 pages). Now more details are provided on the work

Published
2018

40. Choreographies for Reactive Programming

Author

Carbone, Marco, Montesi, Fabrizio, and Vieira, Hugo Torres

Subjects
Computer Science - Programming Languages
Abstract

Modular programming is a cornerstone in software development, as it allows to build complex systems from the assembly of simpler components, and support reusability and substitution principles. In a distributed setting, component assembly is supported by communication that is often required to follow a prescribed protocol of interaction. In this paper, we present a language for the modular development of distributed systems, where the assembly of components is supported by a choreography that specifies the communication protocol. Our language allows to separate component behaviour, given in terms of reactive data ports, and choreographies, specified as first class entities. This allows us to consider reusability and substitution principles for both components and choreographies. We show how our model can be compiled into a more operational perspective in a provably-correct way, and we present a typing discipline that addresses communication safety and progress of systems, where a notion of substitutability naturally arises.

Published
2018

41. Liver stiffness measurement by vibration-controlled transient elastography improves outcome prediction in primary biliary cholangitis

Author

Corpechot, Christophe, Carrat, Fabrice, Gaouar, Farid, Chau, Frederic, Hirschfield, Gideon, Gulamhusein, Aliya, Montano-Loza, Aldo J., Lytvyak, Ellina, Schramm, Christoph, Pares, Albert, Olivas, Ignasi, Eaton, John E., Osman, Karim T., Dalekos, George, Gatselis, Nikolaos, Nevens, Frederik, Cazzagon, Nora, Zago, Alessandra, Russo, Francesco Paolo, Abbas, Nadir, Trivedi, Palak, Thorburn, Douglas, Saffioti, Francesca, Barkai, Laszlo, Roccarina, Davide, Calvaruso, Vicenza, Fichera, Anna, Delamarre, Adèle, Medina-Morales, Esli, Bonder, Alan, Patwardhan, Vilas, Rigamonti, Cristina, Carbone, Marco, Invernizzi, Pietro, Cristoferi, Laura, van der Meer, Adriaan, de Veer, Rozanne, Zigmond, Ehud, Yehezkel, Eyal, Kremer, Andreas E., Deibel, Ansgar, Dumortier, Jérôme, Bruns, Tony, Große, Karsten, Pageaux, Georges-Philippe, Wetten, Aaron, Dyson, Jessica, Jones, David, Chazouillères, Olivier, Hansen, Bettina, and de Lédinghen, Victor

Published
2022
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43. Role of ductular reaction and ductular–canalicular junctions in identifying severe primary biliary cholangitis

Author

Overi, Diletta, Carpino, Guido, Cristoferi, Laura, Onori, Paolo, Kennedy, Lindsey, Francis, Heather, Zucchini, Nicola, Rigamonti, Cristina, Viganò, Mauro, Floreani, Annarosa, D’Amato, Daphne, Gerussi, Alessio, Venere, Rosanna, Alpini, Gianfranco, Glaser, Shannon, Alvaro, Domenico, Invernizzi, Pietro, Gaudio, Eugenio, Cardinale, Vincenzo, and Carbone, Marco

Published
2022
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46. Transformations of 'Scylla and Charybdis' : encounters with otherness and Ancient Greek myth in post-classical perspective

Author

Carbone, Marco Benoît

Subjects
398.20938
Abstract

This is a study of contemporary uses of the myth of Scylla and Charybdis, often personified as female monstrosities or explained as a rock and whirlpool in Italy’s Strait of Reggio and Messina. Focusing on theoretical, methodological, and disciplinary issues of historical transmission, it addresses media appropriations of these signifiers of Greco-Roman traditions, as well as abject femininity, animality, and Otherness. Nineteenth-century European travellers visited the Strait in search of the landmarks of Homer’s Odyssey. The area attracted the travellers’ antiquarian appreciation of the myth-place and its relation with legends of marine dangers, a narrative that later reached broader audiences through twentieth-century international tourism and media. In parallel, Scylla and Charybdis were popularized as monstrous figures in the imaginaries of travel, horror, fantasy, and erotica. Drawing on deconstructive approaches to myth studies, the thesis analyses the Scylla and Charybdis motif in the broader context of ideas about antiquity in historiographical, psychoanalytic, and positivist perspectives. Looking at under- researched media, such as travel literature, role playing and video games, and pornographic iconography, the study shows how the monsters embodied imagined encounters with the abject, the marvellous, the other-than-self, and the other-than- now. Extending critiques of Greco-Roman history’s exceptionalism developed within reception and cultural studies, the thesis conceptualizes antiquity as a series of reciprocal impacts between the present and the past, and it discusses the pliability of the myth figures and the variety of purposes they served. Ethnographic research in the Strait, presented through an accompanying Documentary Film, demonstrates how the figures became local symbols of selectively philhellenic local histories.

Published
2018

49. On the Boundary between Decidability and Undecidability of Asynchronous Session Subtyping

Author

Bravetti, Mario, Carbone, Marco, and Zavattaro, Gianluigi

Subjects
Computer Science - Programming Languages
Abstract

Session types are behavioural types for guaranteeing that concurrent programs are free from basic communication errors. Recent work has shown that asynchronous session subtyping is undecidable. However, since session types have become popular in mainstream programming languages in which asynchronous communication is the norm rather than the exception, it is crucial to detect significant decidable subtyping relations. Previous work considered extremely restrictive fragments in which limitations were imposed to the size of communication buffer (at most 1) or to the possibility to express multiple choices (disallowing them completely in one of the compared types). In this work, for the first time, we show decidability of a fragment that does not impose any limitation on communication buffers and allows both the compared types to include multiple choices for either input or output, thus yielding a fragment which is more significant from an applicability viewpoint. In general, we study the boundary between decidability and undecidability by considering several fragments of subtyping. Notably, we show that subtyping remains undecidable even if restricted to not using output covariance and input contravariance.

Published
2017

50. Improving predictive accuracy in primary biliary cholangitis: A new genetic risk score.

Author

Gerussi, Alessio, Cappadona, Claudio, Bernasconi, Davide Paolo, Cristoferi, Laura, Valsecchi, Maria Grazia, Carbone, Marco, Invernizzi, Pietro, and Asselta, Rosanna

Subjects
GENETIC risk score, CHOLANGITIS, DISEASE risk factors, HLA histocompatibility antigens, GENETIC variation
Abstract

Background and Aims: Genetic variants influence primary biliary cholangitis (PBC) risk. We established and tested an accurate polygenic risk score (PRS) using these variants. Methods: Data from two Italian cohorts (OldIT 444 cases, 901 controls; NewIT 255 cases, 579 controls) were analysed. The latest international genome‐wide meta‐analysis provided effect size estimates. The PRS, together with human leukocyte antigen (HLA) status and sex, was included in an integrated risk model. Results: Starting from 46 non‐HLA genes, 22 variants were selected. PBC patients in the OldIT cohort showed a higher risk score than controls: −.014 (interquartile range, IQR, −.023,.005) versus −.022 (IQR −.030, −.013) (p < 2.2 × 10−16). For genetic‐based prediction, the area under the curve (AUC) was.72; adding sex increased the AUC to.82. Validation in the NewIT cohort confirmed the model's accuracy (.71 without sex,.81 with sex). Individuals in the top group, representing the highest 25%, had a PBC risk approximately 14 times higher than that of the reference group (lowest 25%; p < 10−6). Conclusion: The combination of sex and a novel PRS accurately discriminated between PBC cases and controls. The model identified a subset of individuals at increased risk of PBC who might benefit from tailored monitoring. [ABSTRACT FROM AUTHOR]

Published
2024
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