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21 results on '"Carbonneau, Seth"'

1. Author Correction: DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Author

Schröder, Martin, Renatus, Martin, Liang, Xiaoyou, Meili, Fabian, Zoller, Thomas, Ferrand, Sandrine, Gauter, Francois, Li, Xiaoyan, Sigoillot, Frederic, Gleim, Scott, Stachyra, Therese-Marie, Thomas, Jason R., Begue, Damien, Khoshouei, Maryam, Lefeuvre, Peggy, Andraos-Rey, Rita, Chung, BoYee, Ma, Renate, Pinch, Benika, Hofmann, Andreas, Schirle, Markus, Schmiedeberg, Niko, Imbach, Patricia, Gorses, Delphine, Calkins, Keith, Bauer-Probst, Beatrice, Maschlej, Magdalena, Niederst, Matt, Maher, Rob, Henault, Martin, Alford, John, Ahrne, Erik, Tordella, Luca, Hollingworth, Greg, Thomä, Nicolas H., Vulpetti, Anna, Radimerski, Thomas, Holzer, Philipp, Carbonneau, Seth, and Thoma, Claudio R.

Published
2024
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2. DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

Author

Schröder, Martin, Renatus, Martin, Liang, Xiaoyou, Meili, Fabian, Zoller, Thomas, Ferrand, Sandrine, Gauter, Francois, Li, Xiaoyan, Sigoillot, Frederic, Gleim, Scott, Stachyra, Therese-Marie, Thomas, Jason R., Begue, Damien, Khoshouei, Maryam, Lefeuvre, Peggy, Andraos-Rey, Rita, Chung, BoYee, Ma, Renate, Pinch, Benika, Hofmann, Andreas, Schirle, Markus, Schmiedeberg, Niko, Imbach, Patricia, Gorses, Delphine, Calkins, Keith, Bauer-Probst, Beatrice, Maschlej, Magdalena, Niederst, Matt, Maher, Rob, Henault, Martin, Alford, John, Ahrne, Erik, Tordella, Luca, Hollingworth, Greg, Thomä, Nicolas H., Vulpetti, Anna, Radimerski, Thomas, Holzer, Philipp, Carbonneau, Seth, and Thoma, Claudio R.

Published
2024
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3. Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy

Author

Bonazzi, Simone, d’Hennezel, Eva, Beckwith, Rohan E.J., Xu, Lei, Fazal, Aleem, Magracheva, Anna, Ramesh, Radha, Cernijenko, Artiom, Antonakos, Brandon, Bhang, Hyo-eun C., Caro, Roxana García, Cobb, Jennifer S., Ornelas, Elizabeth, Ma, Xiaolei, Wartchow, Charles A., Clifton, Matthew C., Forseth, Ry R., Fortnam, Bethany Hughes, Lu, Hongbo, Csibi, Alfredo, Tullai, Jennifer, Carbonneau, Seth, Thomsen, Noel M., Larrow, Jay, Chie-Leon, Barbara, Hainzl, Dominik, Gu, Yi, Lu, Darlene, Meyer, Matthew J., Alexander, Dylan, Kinyamu-Akunda, Jacqueline, Sabatos-Peyton, Catherine A., Dales, Natalie A., Zécri, Frédéric J., Jain, Rishi K., Shulok, Janine, Wang, Y. Karen, Briner, Karin, Porter, Jeffery A., Tallarico, John A., Engelman, Jeffrey A., Dranoff, Glenn, Bradner, James E., Visser, Michael, and Solomon, Jonathan M.

Published
2023
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6. CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

Author

Ross, Nathan T., Lohmann, Felix, Carbonneau, Seth, Fazal, Aleem, Weihofen, Wilhelm A., Gleim, Scott, Salcius, Michael, Sigoillot, Frederic, Henault, Martin, Carl, Sarah H., Rodríguez-Molina, Juan B., Miller, Howard R., Brittain, Scott M., Murphy, Jason, Zambrowski, Mark, Boynton, Geoffrey, Wang, Yuan, Chen, Aye, Molind, Gregory J., Wilbertz, Johannes H., Artus-Revel, Caroline G., Jia, Min, Akinjiyan, Favour A., Turner, Jonathan, Knehr, Judith, Carbone, Walter, Schuierer, Sven, Reece-Hoyes, John S., Xie, Kevin, Saran, Chitra, Williams, Eric T., Roma, Guglielmo, Spencer, Matt, Jenkins, Jeremy, George, Elizabeth L., Thomas, Jason R., Michaud, Gregory, Schirle, Markus, Tallarico, John, Passmore, Lori A., Chao, Jeffrey A., and Beckwith, Rohan E. J.

Published
2020
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8. Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings

Author

Schroeder, Martin, primary, Renatus, Martin, additional, Liang, Xiaoyou, additional, Meili, Fabian, additional, Ferrand, Sandrine, additional, Gauter, Francois, additional, Li, Xiaoyan, additional, Sigoillot, Fred, additional, Gleim, Scott, additional, Stachyra, Marie-Therese, additional, Thomas, Jason, additional, Schirle, Markus, additional, Zoller, Thomas, additional, Begue, Damien, additional, Lefeuvre, Peggy, additional, Chung, BoYee, additional, Ma, Renate, additional, Carbonneau, Seth, additional, Pinch, Benika, additional, Schmiedeberg, Niko, additional, Imbach, Patricia, additional, Hofmann, Andreas, additional, Rey, Rita, additional, Gorses, Delphine, additional, Calkins, Keith, additional, Bauer-Probst, Bea, additional, Maschlej, Magdalena, additional, Niederst, Matt, additional, Maher, Rob, additional, Henault, Martin, additional, Alford, John, additional, Ahrne, Erik, additional, Hollingworth, Greg, additional, Thomae, Nicolas H., additional, Vulpetti, Anna, additional, Radimerski, Thomas, additional, Holzer, Philipp, additional, and Thoma, Claudio R., additional

Published
2023
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9. Author Correction: CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

Author

Ross, Nathan T., Lohmann, Felix, Carbonneau, Seth, Fazal, Aleem, Weihofen, Wilhelm A., Gleim, Scott, Salcius, Michael, Sigoillot, Frederic, Henault, Martin, Carl, Sarah H., Rodríguez-Molina, Juan B., Miller, Howard R., Brittain, Scott M., Murphy, Jason, Zambrowski, Mark, Boynton, Geoffrey, Wang, Yuan, Chen, Aye, Molind, Gregory J., Wilbertz, Johannes H., Artus-Revel, Caroline G., Jia, Min, Akinjiyan, Favour A., Turner, Jonathan, Knehr, Judith, Carbone, Walter, Schuierer, Sven, Reece-Hoyes, John S., Xie, Kevin, Saran, Chitra, Williams, Eric T., Roma, Guglielmo, Spencer, Matt, Jenkins, Jeremy, George, Elizabeth L., Thomas, Jason R., Michaud, Gregory, Schirle, Markus, Tallarico, John, Passmore, Lori A., Chao, Jeffrey A., and Beckwith, Rohan E. J.

Published
2020
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10. Targeted degradation of IKZF2 for cancer immunotherapy

Author

Solomon, Jonathan, primary, Bonazzi, Simone, additional, d'Hennezel, Eva, additional, Beckwith, Rohan, additional, Xu, Lei, additional, Fazal, Aleem, additional, Magracheva, Anna, additional, Ramesh, Radha, additional, Cernijenko, Artiom, additional, Antonakos, Brandon, additional, Bhang, Hyo-eun, additional, Caro, Roxana Garcia, additional, Cobb, Jennifer, additional, Ornelas, Elizabeth, additional, Ma, Xiaolei, additional, Wartchow, Charles, additional, Clifton, Matt, additional, Forseth, Ry, additional, Fortnam, Bethany, additional, Lu, Hongbo, additional, Csibi, Alfredo, additional, Tullai, Jennifer, additional, Carbonneau, Seth, additional, Thomsen, Noel, additional, Larrow, Jay, additional, Chie-Leon, Barbara, additional, Hainzl, Dominik, additional, Gu, Yi, additional, Lu, Darlene, additional, Meyer, Matthew, additional, Alexander, Dylan, additional, Kinyamu-Akunda, Jacqueline, additional, Sabatos-Peyton, Catherine, additional, Dales, Natalie, additional, Zecri, Frederic, additional, Jain, Rishi, additional, Shulok, Janine, additional, Wang, Y. Karen, additional, Briner, Karin, additional, Porter, Jeffrey, additional, Tallarico, John, additional, Engelman, Jeffrey, additional, Dranoff, Glenn, additional, Bradner, Jay, additional, and Visser, Michael, additional

Published
2022
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11. Supplemental_material_novel_high_throughput_ubiquitination_Akinjiyan_legends – Supplemental material for A Novel Luminescence-Based High-Throughput Approach for Cellular Resolution of Protein Ubiquitination Using Tandem Ubiquitin Binding Entities (TUBEs)

Author

Favour A. Akinjiyan, Aleem Fazal, Hild, Marc, Beckwith, Rohan E. J., Ross, Nathan T., Joshiawa Paulk, and Carbonneau, Seth

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, Supplemental_material_novel_high_throughput_ubiquitination_Akinjiyan_legends for A Novel Luminescence-Based High-Throughput Approach for Cellular Resolution of Protein Ubiquitination Using Tandem Ubiquitin Binding Entities (TUBEs) by Favour A. Akinjiyan, Aleem Fazal, Marc Hild, Rohan E. J. Beckwith, Nathan T. Ross, Joshiawa Paulk and Seth Carbonneau in SLAS Discovery

Published
2020
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12. The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus

Author

Robertson, Anthony J., Croce, Jenifer, Carbonneau, Seth, Voronina, Ekaterina, Miranda, Esther, McClay, David R., and Coffman, James A.

Subjects
Sea urchins -- Genetic aspects, Cell death -- Analysis, Genomes -- Analysis, Apoptosis -- Analysis, Biological sciences
Abstract

A study on the death of cell of sea urchins examines the proteins found in its genome.

Published
2006

14. CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

Author

Ross, Nathan T., primary, Lohmann, Felix, additional, Carbonneau, Seth, additional, Fazal, Aleem, additional, Weihofen, Wilhelm A., additional, Gleim, Scott, additional, Salcius, Michael, additional, Sigoillot, Frederic, additional, Henault, Martin, additional, Carl, Sarah H., additional, Rodríguez-Molina, Juan B., additional, Miller, Howard R., additional, Brittain, Scott M., additional, Murphy, Jason, additional, Zambrowski, Mark, additional, Boynton, Geoffrey, additional, Wang, Yuan, additional, Chen, Aye, additional, Molind, Gregory J., additional, Wilbertz, Johannes H., additional, Artus-Revel, Caroline G., additional, Jia, Min, additional, Akinjiyan, Favour A., additional, Turner, Jonathan, additional, Knehr, Judith, additional, Carbone, Walter, additional, Schuierer, Sven, additional, Reece-Hoyes, John S., additional, Xie, Kevin, additional, Saran, Chitra, additional, Williams, Eric T., additional, Roma, Guglielmo, additional, Spencer, Matt, additional, Jenkins, Jeremy, additional, George, Elizabeth L., additional, Thomas, Jason R., additional, Michaud, Gregory, additional, Schirle, Markus, additional, Tallarico, John, additional, Passmore, Lori A., additional, Chao, Jeffrey A., additional, and Beckwith, Rohan E. J., additional

Published
2019
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17. The genome of the sea urchin Strongylocentrotus purpuratus

Author

Sodergren, Erica, Weinstock, George M., Davidson, Eric H., Cameron, R. Andrew, Gibbs, Richard A., Angerer, Robert C., Angerer, Lynne M., Arnone, Maria Ina, Burgess, David R., Burke, Robert D., Coffman, James A., Dean, Michael, Elphick, Maurice R., Ettensohn, Charles A., Foltz, Kathy R., Hamdoun, Amro, Hynes, Richard O., Klein, William H., Marzluff, William, McClay, David R., Morris, Robert L., Mushegian, Arcady, Rast, Jonathan P., Smith, L. Courtney, Thorndyke, Michael C., Vacquier, Victor D., Wessel, Gary M., Wray, Greg, Zhang, Lan, Elsik, Christine G., Ermolaeva, Olga, Hlavina, Wratko, Hofmann, Gretchen, Kitts, Paul, Landrum, Melissa J., Mackey, Aaron J., Maglott, Donna, Panopoulou, Georgia, Poustka, Albert J., Pruitt, Kim, Sapojnikov, Victor, Song, Xingzhi, Souvorov, Alexandre, Solovyev, Victor, Wei, Zheng, Whittaker, Charles A., Worley, Kim, Durbin, K. James, Shen, Yufeng, Fedrigo, Olivier, Garfield, David, Haygood, Ralph, Primus, Alexander, Satija, Rahul, Severson, Tonya, Gonzalez-Garay, Manuel L., Jackson, Andrew R., Milosavljevic, Aleksandar, Tong, Mark, Killian, Christopher E., Livingston, Brian T., Wilt, Fred H., Adams, Nikki, Belle, Robert, Carbonneau, Seth, Cheung, Rocky, Cormier, Patrick, Cosson, Bertrand, Croce, Jenifer, Fernandez-Guerra, Antonio, Geneviere, Anne-Marie, Goel, Manisha, Kelkar, Hemant, Morales, Julia, Mulner-Lorillon, Odile, Robertson, Anthony J., Goldstone, Jared V., Cole, Bryan, Epel, David, Gold, Bert, Hahn, Mark E., Howard-Ashby, Meredith, Scally, Mark, Stegeman, John J., Allgood, Erin L., Cool, Jonah, Judkins, Kyle M., McCafferty, Shawn S., Musante, Ashlan M., Obar, Robert A., Rawson, Amanda P., Rossetti, Blair J., Gibbons, Ian R., Hoffman, Matthew P., Leone, Andrew, Istrail, Sorin, Materna, Stefan C., Samanta, Manoj P., Stolc, Viktor, Tongprasit, Waraporn, Tu, Qiang, Bergeron, Karl-Frederik, Brandhorst, Bruce P., Whittle, James, Berney, Kevin, Bottjer, David J., Calestani, Cristina, Peterson, Kevin, Chow, Elly, Yuan, Qiu Autumn, Elhaik, Eran, Graur, Dan, Reese, Justin T., Bosdet, Ian, Heesun, Shin, Marra, Marco A., Schein, Jacqueline, Anderson, Michele K., Brockton, Virginia, Buckley, Katherine M., Cohen, Avis H., Fugmann, Sebastian D., Hibino, Taku, Loza-Coll, Mariano, Majeske, Audrey J., Messier, Cynthia, Nair, Sham V., Pancer, Zeev, Terwilliger, David P., Agca, Cavit, Arboleda, Enrique, Chen, Nansheng, Churcher, Allison M., Hallböök, Finn, Humphrey, Glen W., Idris, Mohammed M., Kiyama, Takae, Liang, Shuguang, Mellott, Dan, Mu, Xiuqian, Murray, Greg, Olinski, Robert P., Raible, Florian, Rowe, Matthew, Taylor, John S., Tessmar-Raible, Kristin, Wang, D., Wilson, Karen H., Yaguchi, Shunsuke, Gaasterland, Terry, Galindo, Blanca E., Gunaratne, Herath J., Juliano, Celina, Kinukawa, Masashi, Moy, Gary W., Neill, Anna T., Nomura, Mamoru, Raisch, Michael, Reade, Anna, Roux, Michelle M., Song, Jia L., Su, Yi-Hsien, Townley, Ian K., Voronina, Ekaterina, Wong, Julian L., Amore, Gabriele, Branno, Margherita, Brown, Euan R., Cavalieri, Vincenzo, Duboc, Veronique, Duloquin, Louise, Flytzanis, Constantin, Gache, Christian, Lapraz, Francois, Lepage, Thierry, Locascio, Annamaria, Martinez, Pedro, Matassi, Giorgio, Matranga, Valeria, Range, Ryan, Rizzo, Francesca, Roettinger, Eric, Wilson, Karen, Beane, Wendy, Bradham, Cynthia, Byrum, Christine, Glenn, Tom, Hussain, Sofia, Loza, Mariano, Manning, Gerard, Miranda, Esther, Thomason, Rebecca, Walton, Katherine, Wikramanayke, Athula, Whittaker, Charles, Wu, Shu-Yu, Xu, Ronghui, Brown, C. Titus, Chen, Lili, Gray, Rachel F., Lee, Pei Yun, Nam, Jongmin, Oliveri, Paola, Smith, Joel, Muzny, Donna, Bell, Stephanie, Chacko, Joseph, Cree, Andrew, Curry, Stacey, Davis, Clay, Dinh, Huyen, Dugan-Rocha, Shannon, Fowler, Jerry, Gill, Rachel, Hamilton, Cerrissa, Hernandez, Judith, Hines, Sandra, Hume, Jennifer, Jackson, LaRonda, Jolivet, Angela, Kovar, Christie, Lee, Sandra, Lewis, Lora, Miner, George, Morgan, Margaret, Nazareth, Lynne V., Okwuonu, Geoffrey, Parker, David, Pu, Ling-Ling, Thom, Rachel, Wright, Rita, Sodergren, Erica, Weinstock, George M., Davidson, Eric H., Cameron, R. Andrew, Gibbs, Richard A., Angerer, Robert C., Angerer, Lynne M., Arnone, Maria Ina, Burgess, David R., Burke, Robert D., Coffman, James A., Dean, Michael, Elphick, Maurice R., Ettensohn, Charles A., Foltz, Kathy R., Hamdoun, Amro, Hynes, Richard O., Klein, William H., Marzluff, William, McClay, David R., Morris, Robert L., Mushegian, Arcady, Rast, Jonathan P., Smith, L. Courtney, Thorndyke, Michael C., Vacquier, Victor D., Wessel, Gary M., Wray, Greg, Zhang, Lan, Elsik, Christine G., Ermolaeva, Olga, Hlavina, Wratko, Hofmann, Gretchen, Kitts, Paul, Landrum, Melissa J., Mackey, Aaron J., Maglott, Donna, Panopoulou, Georgia, Poustka, Albert J., Pruitt, Kim, Sapojnikov, Victor, Song, Xingzhi, Souvorov, Alexandre, Solovyev, Victor, Wei, Zheng, Whittaker, Charles A., Worley, Kim, Durbin, K. James, Shen, Yufeng, Fedrigo, Olivier, Garfield, David, Haygood, Ralph, Primus, Alexander, Satija, Rahul, Severson, Tonya, Gonzalez-Garay, Manuel L., Jackson, Andrew R., Milosavljevic, Aleksandar, Tong, Mark, Killian, Christopher E., Livingston, Brian T., Wilt, Fred H., Adams, Nikki, Belle, Robert, Carbonneau, Seth, Cheung, Rocky, Cormier, Patrick, Cosson, Bertrand, Croce, Jenifer, Fernandez-Guerra, Antonio, Geneviere, Anne-Marie, Goel, Manisha, Kelkar, Hemant, Morales, Julia, Mulner-Lorillon, Odile, Robertson, Anthony J., Goldstone, Jared V., Cole, Bryan, Epel, David, Gold, Bert, Hahn, Mark E., Howard-Ashby, Meredith, Scally, Mark, Stegeman, John J., Allgood, Erin L., Cool, Jonah, Judkins, Kyle M., McCafferty, Shawn S., Musante, Ashlan M., Obar, Robert A., Rawson, Amanda P., Rossetti, Blair J., Gibbons, Ian R., Hoffman, Matthew P., Leone, Andrew, Istrail, Sorin, Materna, Stefan C., Samanta, Manoj P., Stolc, Viktor, Tongprasit, Waraporn, Tu, Qiang, Bergeron, Karl-Frederik, Brandhorst, Bruce P., Whittle, James, Berney, Kevin, Bottjer, David J., Calestani, Cristina, Peterson, Kevin, Chow, Elly, Yuan, Qiu Autumn, Elhaik, Eran, Graur, Dan, Reese, Justin T., Bosdet, Ian, Heesun, Shin, Marra, Marco A., Schein, Jacqueline, Anderson, Michele K., Brockton, Virginia, Buckley, Katherine M., Cohen, Avis H., Fugmann, Sebastian D., Hibino, Taku, Loza-Coll, Mariano, Majeske, Audrey J., Messier, Cynthia, Nair, Sham V., Pancer, Zeev, Terwilliger, David P., Agca, Cavit, Arboleda, Enrique, Chen, Nansheng, Churcher, Allison M., Hallböök, Finn, Humphrey, Glen W., Idris, Mohammed M., Kiyama, Takae, Liang, Shuguang, Mellott, Dan, Mu, Xiuqian, Murray, Greg, Olinski, Robert P., Raible, Florian, Rowe, Matthew, Taylor, John S., Tessmar-Raible, Kristin, Wang, D., Wilson, Karen H., Yaguchi, Shunsuke, Gaasterland, Terry, Galindo, Blanca E., Gunaratne, Herath J., Juliano, Celina, Kinukawa, Masashi, Moy, Gary W., Neill, Anna T., Nomura, Mamoru, Raisch, Michael, Reade, Anna, Roux, Michelle M., Song, Jia L., Su, Yi-Hsien, Townley, Ian K., Voronina, Ekaterina, Wong, Julian L., Amore, Gabriele, Branno, Margherita, Brown, Euan R., Cavalieri, Vincenzo, Duboc, Veronique, Duloquin, Louise, Flytzanis, Constantin, Gache, Christian, Lapraz, Francois, Lepage, Thierry, Locascio, Annamaria, Martinez, Pedro, Matassi, Giorgio, Matranga, Valeria, Range, Ryan, Rizzo, Francesca, Roettinger, Eric, Wilson, Karen, Beane, Wendy, Bradham, Cynthia, Byrum, Christine, Glenn, Tom, Hussain, Sofia, Loza, Mariano, Manning, Gerard, Miranda, Esther, Thomason, Rebecca, Walton, Katherine, Wikramanayke, Athula, Whittaker, Charles, Wu, Shu-Yu, Xu, Ronghui, Brown, C. Titus, Chen, Lili, Gray, Rachel F., Lee, Pei Yun, Nam, Jongmin, Oliveri, Paola, Smith, Joel, Muzny, Donna, Bell, Stephanie, Chacko, Joseph, Cree, Andrew, Curry, Stacey, Davis, Clay, Dinh, Huyen, Dugan-Rocha, Shannon, Fowler, Jerry, Gill, Rachel, Hamilton, Cerrissa, Hernandez, Judith, Hines, Sandra, Hume, Jennifer, Jackson, LaRonda, Jolivet, Angela, Kovar, Christie, Lee, Sandra, Lewis, Lora, Miner, George, Morgan, Margaret, Nazareth, Lynne V., Okwuonu, Geoffrey, Parker, David, Pu, Ling-Ling, Thom, Rachel, and Wright, Rita

Abstract

We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.

Published
2006
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18. Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53

Author

Sorrells, Shelly, primary, Carbonneau, Seth, additional, Harrington, Erik, additional, Chen, Aye T., additional, Hast, Bridgid, additional, Milash, Brett, additional, Pyati, Ujwal, additional, Major, Michael B., additional, Zhou, Yi, additional, Zon, Leonard I., additional, Stewart, Rodney A., additional, Look, A. Thomas, additional, and Jette, Cicely, additional

Published
2012
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20. The Genome of the Sea Urchin Strongylocentrotus purpuratus

Author

Sodergren, Erica, primary, Weinstock, George M., additional, Davidson, Eric H, additional, Cameron, R. Andrew, additional, Gibbs, Richard A., additional, Angerer, Robert C., additional, Angerer, Lynne M., additional, Arnone, Maria Ina, additional, Burgess, David R., additional, Burke, Robert D., additional, Coffman, James A., additional, Dean, Michael, additional, Elphick, Maurice R., additional, Ettensohn, Charles A., additional, Foltz, Kathy R., additional, Hamdoun, Amro, additional, Hynes, Richard O., additional, Klein, William H., additional, Marzluff, William, additional, McClay, David R., additional, Morris, Robert L., additional, Mushegian, Arcady, additional, Rast, Jonathan P., additional, Smith, L. Courtney, additional, Thorndyke, Michael C., additional, Vacquier, Victor D., additional, Wessel, Gary M., additional, Wray, Greg, additional, Zhang, Lan, additional, Elsik, Christine G., additional, Ermolaeva, Olga, additional, Hlavina, Wratko, additional, Hofmann, Gretchen, additional, Kitts, Paul, additional, Landrum, Melissa J., additional, Mackey, Aaron J., additional, Maglott, Donna, additional, Panopoulou, Georgia, additional, Poustka, Albert J., additional, Pruitt, Kim, additional, Sapojnikov, Victor, additional, Song, Xingzhi, additional, Souvorov, Alexandre, additional, Solovyev, Victor, additional, Wei, Zheng, additional, Whittaker, Charles A., additional, Worley, Kim, additional, Durbin, K. James, additional, Shen, Yufeng, additional, Fedrigo, Olivier, additional, Garfield, David, additional, Haygood, Ralph, additional, Primus, Alexander, additional, Satija, Rahul, additional, Severson, Tonya, additional, Gonzalez-Garay, Manuel L., additional, Jackson, Andrew R., additional, Milosavljevic, Aleksandar, additional, Tong, Mark, additional, Killian, Christopher E., additional, Livingston, Brian T., additional, Wilt, Fred H., additional, Adams, Nikki, additional, Bellé, Robert, additional, Carbonneau, Seth, additional, Cheung, Rocky, additional, Cormier, Patrick, additional, Cosson, Bertrand, additional, Croce, Jenifer, additional, Fernandez-Guerra, Antonio, additional, Genevière, Anne-Marie, additional, Goel, Manisha, additional, Kelkar, Hemant, additional, Morales, Julia, additional, Mulner-Lorillon, Odile, additional, Robertson, Anthony J., additional, Goldstone, Jared V., additional, Cole, Bryan, additional, Epel, David, additional, Gold, Bert, additional, Hahn, Mark E., additional, Howard-Ashby, Meredith, additional, Scally, Mark, additional, Stegeman, John J., additional, Allgood, Erin L., additional, Cool, Jonah, additional, Judkins, Kyle M., additional, McCafferty, Shawn S., additional, Musante, Ashlan M., additional, Obar, Robert A., additional, Rawson, Amanda P., additional, Rossetti, Blair J., additional, Gibbons, Ian R., additional, Hoffman, Matthew P., additional, Leone, Andrew, additional, Istrail, Sorin, additional, Materna, Stefan C., additional, Samanta, Manoj P., additional, Stolc, Viktor, additional, Tongprasit, Waraporn, additional, Tu, Qiang, additional, Bergeron, Karl-Frederik, additional, Brandhorst, Bruce P., additional, Whittle, James, additional, Berney, Kevin, additional, Bottjer, David J., additional, Calestani, Cristina, additional, Peterson, Kevin, additional, Chow, Elly, additional, Yuan, Qiu Autumn, additional, Elhaik, Eran, additional, Graur, Dan, additional, Reese, Justin T., additional, Bosdet, Ian, additional, Heesun, Shin, additional, Marra, Marco A., additional, Schein, Jacqueline, additional, Anderson, Michele K., additional, Brockton, Virginia, additional, Buckley, Katherine M., additional, Cohen, Avis H., additional, Fugmann, Sebastian D., additional, Hibino, Taku, additional, Loza-Coll, Mariano, additional, Majeske, Audrey J., additional, Messier, Cynthia, additional, Nair, Sham V., additional, Pancer, Zeev, additional, Terwilliger, David P., additional, Agca, Cavit, additional, Arboleda, Enrique, additional, Chen, Nansheng, additional, Churcher, Allison M., additional, Hallböök, F., additional, Humphrey, Glen W., additional, Idris, Mohammed M., additional, Kiyama, Takae, additional, Liang, Shuguang, additional, Mellott, Dan, additional, Mu, Xiuqian, additional, Murray, Greg, additional, Olinski, Robert P., additional, Raible, Florian, additional, Rowe, Matthew, additional, Taylor, John S., additional, Tessmar-Raible, Kristin, additional, Wang, D., additional, Wilson, Karen H., additional, Yaguchi, Shunsuke, additional, Gaasterland, Terry, additional, Galindo, Blanca E., additional, Gunaratne, Herath J., additional, Juliano, Celina, additional, Kinukawa, Masashi, additional, Moy, Gary W., additional, Neill, Anna T., additional, Nomura, Mamoru, additional, Raisch, Michael, additional, Reade, Anna, additional, Roux, Michelle M., additional, Song, Jia L., additional, Su, Yi-Hsien, additional, Townley, Ian K., additional, Voronina, Ekaterina, additional, Wong, Julian L., additional, Amore, Gabriele, additional, Branno, Margherita, additional, Brown, Euan R., additional, Cavalieri, Vincenzo, additional, Duboc, Véronique, additional, Duloquin, Louise, additional, Flytzanis, Constantin, additional, Gache, Christian, additional, Lapraz, François, additional, Lepage, Thierry, additional, Locascio, Annamaria, additional, Martinez, Pedro, additional, Matassi, Giorgio, additional, Matranga, Valeria, additional, Range, Ryan, additional, Rizzo, Francesca, additional, Röttinger, Eric, additional, Beane, Wendy, additional, Bradham, Cynthia, additional, Byrum, Christine, additional, Glenn, Tom, additional, Hussain, Sofia, additional, Manning, Gerard, additional, Miranda, Esther, additional, Thomason, Rebecca, additional, Walton, Katherine, additional, Wikramanayke, Athula, additional, Wu, Shu-Yu, additional, Xu, Ronghui, additional, Brown, C. 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Published
2006
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21. Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53

Author

Zon, Leonard I., Milash, Brett, Harrington, Erik, Jette, Cicely, Pyati, Ujwal, Sorrells, Shelly, Hast, Bridgid, Carbonneau, Seth, Look, A. Thomas, Stewart, Rodney A., Major, Michael B., Zhou, Yi, and Chen, Aye T.

Subjects
3. Good health
Abstract

DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought to mediate the successful elimination of cancer cells. However, cancer cells often evolve to evade the cytotoxicity induced by DNA DSBs, thereby forming the basis for treatment resistance. As such, a better understanding of the DSB DNA damage response (DSB–DDR) pathway will facilitate the design of more effective strategies to overcome chemo- and radioresistance. To identify novel mechanisms that protect cells from the cytotoxic effects of DNA DSBs, we performed a forward genetic screen in zebrafish for recessive mutations that enhance the IR–induced apoptotic response. Here, we describe radiosensitizing mutation 7 (rs7), which causes a severe sensitivity of zebrafish embryonic neurons to IR–induced apoptosis and is required for the proper development of the central nervous system. The rs7 mutation disrupts the coding sequence of ccdc94, a highly conserved gene that has no previous links to the DSB–DDR pathway. We demonstrate that Ccdc94 is a functional member of the Prp19 complex and that genetic knockdown of core members of this complex causes increased sensitivity to IR–induced apoptosis. We further show that Ccdc94 and the Prp19 complex protect cells from IR–induced apoptosis by repressing the expression of p53 mRNA. In summary, we have identified a new gene regulating a dosage-sensitive response to DNA DSBs during embryonic development. Future studies in human cancer cells will determine whether pharmacological inactivation of CCDC94 reduces the threshold of the cancer cell apoptotic response.

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