1. A Meta-Analysis Evaluating Clinical Outcomes of Patients with Renal Cell Carcinoma Harboring Chromosome 9P Loss
- Author
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Matteo Brunelli, Michelangelo Fiorentino, Matteo Santoni, Riccardo Schiavina, Francesco Massari, Albino Eccher, Veronica Mollica, Anna Caliò, Guido Martignoni, Lidia Gatto, Michele Milella, Vincenzo Di Nunno, Rodolfo Montironi, Eugenio Brunocilla, and Di Nunno V, Mollica V, Brunelli M, Gatto L, Schiavina R, Fiorentino M, Santoni M, Montironi R, Caliò A, Eccher A, Milella M, Martignoni G, Brunocilla E, Massari F
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Renal oncocytoma ,Population ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Neoplasms ,Internal medicine ,Genetics ,medicine ,Carcinoma ,Humans ,Genetic Predisposition to Disease ,Renal Cell Carcinoma, Chromosome 9P Loss, Clinical Outcomes ,education ,Carcinoma, Renal Cell ,Genetic Association Studies ,Survival analysis ,Pharmacology ,education.field_of_study ,business.industry ,Hazard ratio ,Renal Cell ,General Medicine ,Prognosis ,medicine.disease ,Survival Analysis ,Kidney Neoplasms ,Confidence interval ,Patient Outcome Assessment ,030104 developmental biology ,Carcinoma, Renal Cell, Neoplasms, Renal oncocytoma ,030220 oncology & carcinogenesis ,Relative risk ,Meta-analysis ,Molecular Medicine ,Chromosome Deletion ,Chromosomes, Human, Pair 9 ,business - Abstract
CONTEXT: 9p loss appears a reliable and promising marker able to differentiate specific categories of patients with renal cell carcinoma associated with a worse prognosis. OBJECTIVE: The aim was to systematically evaluate relative risk of death, cancer-specific survival (CSS) and disease-free survival (DFS) among patients harboring 9p loss. EVIDENCE SYNTHESIS: We found a total of 92 potentially relevant articles focused on the detection of 9p loss in patients with renal cell carcinoma and clinical outcomes of this population. Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were employed to carry out this work. Fourteen studies resulted to be eligible for this analysis; 11 of these reported data on 5-year overall survival, six on CSS and four on DFS. An increased risk of death has been observed in patients harboring 9p loss (pooled relative risk of 3.965; 95% confidence interval [CI] 2.647-5.940, p
- Published
- 2019
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