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3. Walking naturally after spinal cord injury using a brain–spine interface

Author

Lorach, Henri, Galvez, Andrea, Spagnolo, Valeria, Martel, Felix, Karakas, Serpil, Intering, Nadine, Vat, Molywan, Faivre, Olivier, Harte, Cathal, Komi, Salif, Ravier, Jimmy, Collin, Thibault, Coquoz, Laure, Sakr, Icare, Baaklini, Edeny, Hernandez-Charpak, Sergio Daniel, Dumont, Gregory, Buschman, Rik, Buse, Nicholas, Denison, Tim, van Nes, Ilse, Asboth, Leonie, Watrin, Anne, Struber, Lucas, Sauter-Starace, Fabien, Langar, Lilia, Auboiroux, Vincent, Carda, Stefano, Chabardes, Stephan, Aksenova, Tetiana, Demesmaeker, Robin, Charvet, Guillaume, Bloch, Jocelyne, and Courtine, Grégoire

Published
2023
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4. Chronic Pain in Patients with Spinal Muscular Atrophy in Switzerland: A Query to the Spinal Muscular Atrophy Registry

Author

Steiner, Leonie, primary, Tscherter, Anne, additional, Henzi, Bettina, additional, Branca, Mattia, additional, Carda, Stefano, additional, Enzmann, Cornelia, additional, Fluss, Joël, additional, Jacquier, David, additional, Neuwirth, Christoph, additional, Ripellino, Paolo, additional, Scheidegger, Olivier, additional, Schlaeger, Regina, additional, Schreiner, Bettina, additional, Stettner, Georg M., additional, and Klein, Andrea, additional

Published
2024
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5. Multimodal therapy and use of adjunctive therapies to BoNT-A in spasticity management: defining terminology to help enhance spasticity treatment.

Author

Reebye, Rajiv, Jacinto, Luis Jorge, Balbert, Alexander, Biering-Sørensen, Bo, Carda, Stefano, Draulans, Nathalie, Molteni, Franco, O'Dell, Michael W., Picelli, Alessandro, Santamato, Andrea, Verduzco-Gutierrez, Monica, Walker, Heather, Wissel, Joerg, and Francisco, Gerard E.

Subjects
COMBINED modality therapy, BOTULINUM toxin, TREATMENT programs, ELECTRIC stimulation, TREATMENT effectiveness, SPASTICITY
Abstract

Spasticity management should be provided within the context of a comprehensive person-centered rehabilitation program. Furthermore, active goal setting for specific spasticity interventions is also important, with a well-established "more is better" approach. It is critical to consider adjunctive therapy and multimodal approaches if patients are not attaining their treatment goals. Often used interchangeably, there may be confusion between the terms adjunctive and multimodal therapy. Yet it is imperative to understand the differences between these approaches to achieve treatment goals in spasticity management. Addition of a secondary pharmacologic or non-pharmacologic treatment to optimize the efficacy of the initial modality, such as adding electrical stimulation or casting to BoNT-A, is considered an adjunctive therapy. Adjunctive therapy is time-specific and requires the added therapy be initiated within a specific period to enhance the primary treatment; usually within 2 weeks. Multimodal therapy is an integrated, patient-centric program of pharmacologic and nonpharmacologic strategies utilized in a concurrent/integrated or sequential manner to enhance the overall treatment effect across a variety of spasticityassociated impairments (e.g., neural and non-neural components). Moreover, within a multimodal approach, adjunctive therapy can be used to help enhance the treatment effect of one specific modality. The objectives of this paper are to clarify the differences between adjunctive and multimodal therapies, provide a brief evidence-based review of such approaches, and highlight clinical insights on selecting multimodal and adjunctive therapies in spasticity management. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Targeted neurotechnology restores walking in humans with spinal cord injury

Author

Wagner, Fabien B., Mignardot, Jean-Baptiste, Le Goff-Mignardot, Camille G., Demesmaeker, Robin, Komi, Salif, Capogrosso, Marco, Rowald, Andreas, Seáñez, Ismael, Caban, Miroslav, Pirondini, Elvira, Vat, Molywan, McCracken, Laura A., Heimgartner, Roman, Fodor, Isabelle, Watrin, Anne, Seguin, Perrine, Paoles, Edoardo, Van Den Keybus, Katrien, Eberle, Grégoire, Schurch, Brigitte, Pralong, Etienne, Becce, Fabio, Prior, John, Buse, Nicholas, Buschman, Rik, Neufeld, Esra, Kuster, Niels, Carda, Stefano, von Zitzewitz, Joachim, Delattre, Vincent, Denison, Tim, Lambert, Hendrik, Minassian, Karen, Bloch, Jocelyne, and Courtine, Grégoire

Published
2018
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22. The Lack of Systemic and Subclinical Side Effects of Botulinum Neurotoxin Type-A in Patients Affected by Post-Stroke Spasticity: A Longitudinal Cohort Study

Author

Battaglia, Marco, primary, Borg, Margherita Beatrice, additional, Torgano, Lara, additional, Loro, Alberto, additional, Cosenza, Lucia, additional, Bertoni, Michele, additional, Picelli, Alessandro, additional, Santamato, Andrea, additional, Invernizzi, Marco, additional, Uberti, Francesca, additional, Molinari, Claudio, additional, Carda, Stefano, additional, and Baricich, Alessio, additional

Published
2022
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23. International Recommendations to Manage Poststroke Equinovarus Foot Deformity Validated by a Panel of Experts Using Delphi

Author

Salga, Marjorie, primary, Gatin, Laure, additional, Deltombe, Thierry, additional, Gustin, Thierry, additional, Carda, Stefano, additional, Marque, Philippe, additional, Winston, Paul, additional, Reebye, Rajiv, additional, Wein, Theodore, additional, Esquenazi, Alberto, additional, Keenan, Mary-Ann, additional, Molteni, Franco, additional, Zerbinati, Paolo, additional, Picelli, Alessandro, additional, Coroian, Flavia, additional, Coulet, Bertrand, additional, Sturbois-Nachef, Nadine, additional, Fontaine, Christian, additional, Yelnik, Alain, additional, Parratte, Bernard, additional, Henry, Prakash, additional, Venkatakrishnan, Srikant, additional, Rigoard, Philippe, additional, David, Romain, additional, Denormandie, Philippe, additional, Schnitzler, Alexis, additional, Allart, Etienne, additional, and Genet, François, additional

Published
2022
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24. Module 4

Author

Ketchum, Nicholas, primary, Carda, Stefano, additional, O'Dell, Michael W, additional, Säterö, Patrik, additional, Jacinto, Jorge, additional, Deltombe, Thierry, additional, and Francisco, Gerard E., additional

Published
2022
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25. International recommendations to manage post-stroke Equinovarus Foot deformity validated by a panel of experts using DELPHI.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de médecine physique et revalidation, UCL - (MGD) Service de neurochirurgie, Salga, Marjorie, Gatin, Laure, Deltombe, Thierry, Gustin, Thierry, Carda, Stefano, Marque, Philippe, Winston, Paul, Reebye, Rajiv, Wein, Theodore, Esquenazi, Alberto, Keenan, Mary-Ann, Molteni, Franco, Zerbinati, Paolo, Picelli, Alessandro, Coroian, Flavia, Coulet, Bertrand, Sturbois-Nachef, Nadine, Fontaine, Christian, Yelnik, Alain, Parratte, Bernard, Henry, Prakash, Venkatakrishnan, Srikant, Rigoard, Philippe, David, Romain, Denormandie, Philippe, Schnitzler, Alexis, Allart, Etienne, Genet, François, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de médecine physique et revalidation, UCL - (MGD) Service de neurochirurgie, Salga, Marjorie, Gatin, Laure, Deltombe, Thierry, Gustin, Thierry, Carda, Stefano, Marque, Philippe, Winston, Paul, Reebye, Rajiv, Wein, Theodore, Esquenazi, Alberto, Keenan, Mary-Ann, Molteni, Franco, Zerbinati, Paolo, Picelli, Alessandro, Coroian, Flavia, Coulet, Bertrand, Sturbois-Nachef, Nadine, Fontaine, Christian, Yelnik, Alain, Parratte, Bernard, Henry, Prakash, Venkatakrishnan, Srikant, Rigoard, Philippe, David, Romain, Denormandie, Philippe, Schnitzler, Alexis, Allart, Etienne, and Genet, François

Abstract

This study intended to establish international recommendations for the management of spastic equinovarus foot deformity. Delphi method SETTING: International study PARTICIPANTS: 24 international experts in neuro-orthopedic deformities, from different specialties (Physical and Rehabilitation Medicine physicians, neurologists, geriatricians, orthopaedic surgeons, neurosurgeons, and plastic surgeons) INTERVENTIONS: Experts answered three rounds of questions related to important aspects of diagnosis, assessment and treatment of spastic equinovarus foot deformity. A consensus was established when at least 80% of experts agreed on a statement RESULTS: : A total of 52 items reached consensus. Experts recommend assessing impact of the deformity on functional activities before treatment. Before treatment, it is crucial to differentiate spastic muscle overactivity from soft tissue contractures, identify which muscles are involved in the deformity and evaluate the activity of antagonist muscles. Motor nerve blocks, two-dimensional video analysis and radiological exams are often required to complement a clinical exam. The treatment of equinovarus foot depends on the correctability of the deformity, but also the patient's ability to stand or walk. The preoperative assessment should include an interdisciplinary consultation that must finalize a formal agreement between doctors and the patient, which will define personalized attainable goals before surgery. The establishment of guidelines on managing equinovarus foot will help physicians and surgeons, specialists, and non-specialists to diagnoses and assess the deformity and direct patients to a network of experts, in order to optimize patient functional recovery and improve their autonomy.

Published
2022

26. International Recommendations to Manage Poststroke Equinovarus Foot Deformity Validated by a Panel of Experts Using Delphi.

Author

Salga, Marjorie, Gatin, Laure, Deltombe, Thierry, Gustin, Thierry, Carda, Stefano, Marque, Philippe, Winston, Paul, Reebye, Rajiv, Wein, Theodore, Esquenazi, Alberto, Keenan, Mary-Ann, Molteni, Franco, Zerbinati, Paolo, Picelli, Alessandro, Coroian, Flavia, Coulet, Bertrand, Sturbois-Nachef, Nadine, Fontaine, Christian, Yelnik, Alain, and Parratte, Bernard

Abstract

To establish international recommendations for the management of spastic equinovarus foot deformity. Delphi method. International study. A total of 24 international experts (N=24) in neuro-orthopedic deformities, from different specialties (Physical and Rehabilitation Medicine physicians, neurologists, geriatricians, orthopedic surgeons, neurosurgeons, plastic surgeons). Experts answered 3 rounds of questions related to important aspects of diagnosis, assessment, and treatment of spastic equinovarus foot deformity. A consensus was established when at least 80% of experts agreed on a statement A total of 52 items reached consensus. Experts recommend assessing effect of the deformity on functional activities before treatment. Before treatment, it is crucial to differentiate spastic muscle overactivity from soft tissue contractures, identify which muscles are involved in the deformity, and evaluate the activity of antagonist muscles. Motor nerve blocks, 2-dimensional video analysis, and radiologic examinations are often required to complement a clinical examination. The treatment of equinovarus foot depends on the correctability of the deformity and the patient's ability to stand or walk. The preoperative assessment should include an interdisciplinary consultation that must finalize a formal agreement between physicians and the patient, which will define personalized attainable goals before surgery. The establishment of guidelines on managing equinovarus foot will help physicians and surgeons, specialists, and nonspecialists to diagnoses and assess the deformity and direct patients to a network of experts to optimize patient functional recovery and improve their autonomy. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Ergonomic Recommendations in Ultrasound-Guided Botulinum Neurotoxin Chemodenervation for Spasticity: An International Expert Group Opinion

Author

Lagnau, Philippe, primary, Lo, Alto, additional, Sandarage, Ryan, additional, Alter, Katharine, additional, Picelli, Alessandro, additional, Wissel, Jorg, additional, Verduzco-Gutierrez, Monica, additional, Suputtitada, Areerat, additional, Munin, Michael C., additional, Carda, Stefano, additional, Khan, Omar, additional, Koçer, Serdar, additional, and Reebye, Rajiv, additional

Published
2021
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37. Using Kinematic Analysis to Evaluate Constraint-Induced Movement Therapy in Chronic Stroke Patients

Author

Caimmi, Marco, Carda, Stefano, Giovanzana, Chiara, Maini, Eliseo Stefano, Sabatini, Angelo Maria, Smania, Nicola, and Molteni, Franco

Subjects
Exercise therapy -- Health aspects -- Research -- Usage, Kinematics -- Usage -- Health aspects -- Research, Stroke patients -- Health aspects -- Research -- Usage, Psychology and mental health, Usage, Research, Health aspects
Abstract

Keywords: Constraint-induced therapy; Upper extremity; Biomechanics; Movement; Cerebrovascular accident-Hemiplegia. 31 Using Kinematic Analysis to Evaluate Constraint-Induced Movement Therapy in Chronic Stroke Patients SAGE Publications, Inc.200810.1177/1545968307302923 MarcoCaimmi IR Villa Beretta Rehabilitation [...]

Published
2008
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38. COVID-19 pandemic. What should PRM specialists do? A clinician's perspective

Author

Carda, Stefano, Invernizzi, Marco, Bavikatte, Ganesh, Bensmaïl, Djamel, Bianchi, Francesca, Deltombe, Thierry, Draulans, Nathalie, Esquenazi, Alberto, Francisco, Gerard E, Gross, Raphaël, Jacinto, Luis J, Moraleda Pérez, Susana, O'dell, Michael W, Reebye, Rajiv, Verduzco-Gutierrez, Monica, Wissel, Jörg, Molteni, Franco, UCL - SSS/IONS - Institute of NeuroScience, and UCL - (MGD) Service de médecine physique et revalidation

Abstract

COVID-19 pandemic is rapidly spreading all over the world, creating the risk for an healthcare collapse. While acute care and intensive care units are the main pillars of the early response to the disease, rehabilitative medicine should play an important part in allowing COVID-19 survivors to reduce disability and optimize the function of acute hospital setting. To share the experience and the international perspective of different rehabilitation centers, treating COVID-19 survivors. Not applicable. COVID-19 survivors. A group of Physical Medicine & Rehabilitation specialists from eleven different countries in Europe and North America have shared their clinical experience in dealing with COVID-19 survivors and how they have managed the re-organization of rehabilitation services. In our experience the most important sequelae of severe and critical forms of COVID-19 are: 1) respiratory; 2) cognitive, central and peipheral nervous system; 3) deconditioning; 4) critical illness related myopathy and neuropathy; 5) dysphagia; 6) joint stiffness and pain; 7) psychiatric. We analyze all these consequences and propose some practical treatment options, based on current evidence and clinical experience, as well as several suggestions for management of rehabilitation services and patients with suspected or confirmed infection by SARS-CoV-2. COVID-19 survivors have some specific rehabilitation needs. Experience from other centers may help colleagues in organizing their services and providing better care to their patients.

Published
2020

42. Efficacy of a hip flexion assist orthosis in adults with hemiparesis after stroke

Author

Carda, Stefano, Invernizzi, Marco, Cognolato, Gianluca, Piccoli, Eugenio, Baricich, Alessio, and Cisari, Carlo

Subjects
Stroke (Disease) -- Physiological aspects -- Patient outcomes, Orthopedic equipment and supplies -- Usage, Therapeutics, Physiological -- Methods -- Patient outcomes, Physical therapy -- Methods -- Patient outcomes, Hemiplegia -- Care and treatment -- Physiological aspects, Health
Abstract

Background. During gait, the hip flexors generate 40% of the total power. Nevertheless, no device has been tested extensively for clinical purposes to cope with weakness in the hip flexors in patients with stroke. Objective. The purpose of this study was to assess the efficacy and safety of a newly developed hip flexion assist orthosis in adult patients with hemiparesis after stroke. Design. The study used a prospective, randomized, before-after trial design. The inclusion criteria were hemiparesis resulting from stroke (onset [greater than or equal to]8 weeks); ability to walk, even ff with assistance; and hip flexion weakness (Medical Research Council Scale score [less than or equal to]4). Methods. The main outcome measures were the 10-Meter Walk Test and the Six-Minute Walk Test. Patients also were evaluated with the Trunk Control Test, the Functional Ambulation Categories, the Motricity Index, and hip flexor strength on the Medical Research Council Scale. Sixty-two survivors of stroke were tested in random order with and without the orthosis. Any adverse event associated with its use was recorded. Results. Both the Six-Minute Walk Test and the 10-Meter Walk Test scores improved with the use of the orthosis. A significant negative correlation was found for improvement between scores on the 2 main outcome measures with the orthosis and the Functional Ambulation Categories scores. The improvement in Six-Minute Walk Test scores with the orthosis was related inversely to hip flexor strength. Conclusions. The data showed that the use of a hip flexion assist orthosis can improve gait in patients with poststroke hemiparesis, particularly those with more severe walking impairment., Stroke, the primary cause of adult disability, leads to impairments in mobility and walking. Even though about a third of patients with stroke survive 5 years after the event, mobility [...]

Published
2012
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43. COVID-19 pandemic. What should Physical and Rehabilitation Medicine specialists do? A clinician's perspective

Author

Carda, Stefano, primary, Invernizzi, Marco, additional, Bavikatte, Ganesh, additional, Bensmaïl, Djamel, additional, Bianchi, Francesca, additional, Deltombe, Thierry, additional, Draulans, Nathalie, additional, Esquenazi, Alberto, additional, Francisco, Gerard E., additional, Gross, Raphaël, additional, Jacinto, Luis J., additional, Moraleda Pérez, Susana, additional, O'''''Dell, Michael W., additional, Reebye, Rajiv, additional, Verduzco-Gutierrez, Monica, additional, Wissel, Jörg, additional, and Molteni, Franco, additional

Published
2020
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50. A PRACTICAL GUIDE TO OPTIMIZING THE BENEFITS OF POST-STROKE SPASTICITY INTERVENTIONS WITH BOTULINUM TOXIN A: AN INTERNATIONAL GROUP CONSENSUS.

Author

FRANCISCO, Gerard E., BALBERT, Alexander, BAVIKATTE, Ganesh, BENSMAIL, Djamel, CARDA, Stefano, DELTOMBE, Thierry, DRAULANS, Nathalie, ESCALDI, Steven, GROSS, Raphaël, JACINTO, Jorge, KETCHUM, Nicholas, MOLTENI, Franco, MORALEDA, Susana, O'DELL, Michael W., REEBYE, Rajiv, SÄTERÖ, Patrik, VERDUZCO-GUTIERREZ, Monica, WALKER, Heather, and WISSEL, Jörg

Published
2021
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