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11 results on '"Cardeiro, Alexander"'

4. The combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events

Author

Osborne, Michael T., primary, Abohashem, Shady, additional, Naddaf, Nicki, additional, Abbasi, Taimur, additional, Zureigat, Hadil, additional, Mezue, Kenechukwu, additional, Ghoneem, Ahmed, additional, Dar, Tawseef, additional, Cardeiro, Alexander J., additional, Mehta, Nehal N., additional, Rajagopalan, Sanjay, additional, Fayad, Zahi A., additional, and Tawakol, Ahmed, additional

Published
2022
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7. Abstract 13203: Exercise Decreases Stress-Associated Neural Activity Predominantly by Upregulating Regulatory Medial Prefrontal Cortical Activity

Author

Zureigat, Hadil, primary, Abohashem, Shady, additional, Gharios, Charbel, additional, Mezue, Kenechukwu, additional, Abbasi, Taimur, additional, Cardeiro, Alexander, additional, Shin, Lisa, additional, Baggish, Aaron L, additional, Fayad, Zahi A, additional, Osborne, Michael, additional, and Tawakol, Ahmed A, additional

Published
2021
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8. Abstract 12985: Genetic Susceptibility for Coronary Artery Disease Accentuates the Cardiovascular Disease Risk Associated With Air Pollution

Author

Abohashem, Shady, primary, Abbasi, Taimur, additional, Atlas, Samantha, additional, Atlas, Diana, additional, Zureigat, Hadil, additional, Gharios, Charbel, additional, Mezue, Kenechukwu, additional, Cardeiro, Alexander, additional, Aragam, Krishna, additional, Rajagopalan, Sanjay, additional, Khera, Amit V, additional, Osborne, Michael T, additional, and Tawakol, Ahmed A, additional

Published
2021
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11. Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk.

Author

Mezue, Kenechukwu, Osborne, Michael T., Abohashem, Shady, Zureigat, Hadil, Gharios, Charbel, Grewal, Simran S., Radfar, Azar, Cardeiro, Alexander, Abbasi, Taimur, Choi, Karmel W., Fayad, Zahi A., Smoller, Jordan W., Rosovsky, Rachel, Shin, Lisa, Pitman, Roger, and Tawakol, Ahmed

Subjects
*MAJOR adverse cardiovascular events, *CARDIOVASCULAR diseases risk factors, *POSITRON emission tomography, *HEALTH behavior, *PSYCHOLOGICAL stress
Abstract

Chronic stress associates with major adverse cardiovascular events (MACE) via increased stress-related neural network activity (SNA). Light/moderate alcohol consumption (AC l/m) has been linked to lower MACE risk, but the mechanisms are unclear. The purpose of this study was to evaluate whether the association between AC l/m and MACE is mediated by decreased SNA. Individuals enrolled in the Mass General Brigham Biobank who completed a health behavior survey were studied. A subset underwent 18F-fluorodeoxyglucose positron emission tomography, enabling assessment of SNA. Alcohol consumption was classified as none/minimal, light/moderate, or high (<1, 1-14, or >14 drinks/week, respectively). Of 53,064 participants (median age 60 years, 60% women), 23,920 had no/minimal alcohol consumption and 27,053 AC l/m. Over a median follow-up of 3.4 years, 1,914 experienced MACE. AC l/m (vs none/minimal) associated with lower MACE risk (HR: 0.786; 95% CI: 0.717-0.862; P < 0.0001) after adjusting for cardiovascular risk factors. In 713 participants with brain imaging, AC l/m (vs none/minimal) associated with decreased SNA (standardized beta −0.192; 95% CI: −0.338 to −0.046; P = 0.01). Lower SNA partially mediated the beneficial effect of AC l/m on MACE (log OR: −0.040; 95% CI: −0.097 to −0.003; P < 0.05). Further, AC l/m associated with larger decreases in MACE risk among individuals with (vs without) prior anxiety (HR: 0.60 [95% CI: 0.50-0.72] vs 0.78 [95% CI: 0.73-0.80]; P interaction = 0.003). AC l/m associates with reduced MACE risk, in part, by lowering activity of a stress-related brain network known for its association with cardiovascular disease. Given alcohol's potential health detriments, new interventions with similar effects on SNA are needed. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2023
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