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7. Comparative Study of Lipid Profile for Mice Treated with Cyclophosphamide by HPLC-HRMS and Bioinformatics.

Author

Demicheva, Ekaterina, Polanco Espino, Fernando Jonathan, Vedeneev, Pavel, Shevyrin, Vadim, Buhler, Aleksey, Mukhlynina, Elena, Berdiugina, Olga, Mondragon, Alicia del Carmen, Cepeda Sáez, Alberto, Lopez-Santamarina, Aroa, Cardelle-Cobas, Alejandra, Solovyova, Olga, Danilova, Irina, Miranda, Jose Manuel, and Kovaleva, Elena

Subjects
BLOOD testing, MASS spectrometry, LIPIDOMICS, DIAGNOSIS, BIOMARKERS, BLOOD plasma
Abstract

Purpose: Immunodeficiency conditions, which are characterized by reduced immune activity that promotes the development of chronic diseases, are needed for efficient monitoring. A promising area of monitoring and early diagnosis of immunodeficiency diseases is the determination of metabolic biomarkers in the blood. Methods: In this work, we identified a set of lipid biomarkers of immunodeficiency states by performing high-performance liquid chromatography–high-resolution mass spectrometry (HPLC-HRMS) analysis of blood plasma samples from mice and processing them with bioinformatics approaches. Potential biomarkers were selected through statistical analysis and further validated by MS/MS. Conclusions: As a result, 15 lipids were confirmed and selected as potential biomarkers of immunodeficiency states. The selected biomarkers can be further studied and serve as promising targets for the early diagnosis of immunodeficiency diseases. [ABSTRACT FROM AUTHOR]

Published
2025
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9. Contributors

Author

Aguilar, José Francisco Noguera, primary, Alhayek-Aí, Mohammed, additional, Alonso Aguirre, Pedro A., additional, Álvarez-Chaver, Paula, additional, Alvarez-Gonzalez, Sara, additional, Álvarez-Santullano, Lucía, additional, Alvariño, Javier Castro, additional, Amigo, Jorge, additional, Antón Aparicio, Luis M., additional, Aptsiauri, Natalia, additional, Ares, María Sánchez, additional, Balea, Begoña Campos, additional, Balo, Paula Vieiro, additional, Barcia, Lucía, additional, Bou, Germán, additional, Barreiro, Vanesa Balboa, additional, Bendayán, Isaac Martínez, additional, Bernal, Mónica, additional, Briones, Pedro Carpintero, additional, Brozos-Vázquez, Elena, additional, Bueno, Begoña Bravo, additional, Burundarena, Alba, additional, Caamaño, Antonio Gómez, additional, Calviño, José Manuel Mera, additional, Calvo, Marcos, additional, Candamio-Folgar, Sonia, additional, Cardelle-Cobas, Alejandra, additional, Carracedo, Ángel, additional, Carrasco, Ainhoa, additional, Castro, Álvaro Gómez, additional, Castro, Ana María Carballo, additional, Cepeda, Alberto, additional, Cepeda-Emiliani, Alfonso, additional, Concha, Ángel, additional, Conde, Benito González, additional, Cordero, Oscar J., additional, Cortés, Alberto Centeno, additional, Cotoré, Jesús Paredes, additional, Crespo, Patricia Calvo, additional, de Castro, Alain García, additional, De Chiara, Loretta, additional, de la Ballina González, Enrique González, additional, de Llano, Sofía Rodríguez Martínez, additional, Deben, Manuel Núñez, additional, del Carmen Corujeira Rivera, M., additional, Díaz, Cristina Méndez, additional, Díaz, Sonia Pértega, additional, Diéguez, Leticia García, additional, D'Jesús, Antonio Rodríguez, additional, Dourado, Ramón Vázquez, additional, Dovigo, Alba Gómez, additional, Fajardo, Paloma Sosa, additional, Fernández, Nereida Fernández, additional, Fernández, Rafaela Soler, additional, Fernández, Rosalía, additional, Fernández, Sergio Manuel Estévez, additional, Fernandez-Lozano, Carlos, additional, Fernández-Rozadilla, Ceres, additional, Ferreiro, Raquel Sardina, additional, Ferreiro, Silvia Varela, additional, Figueiras, Roberto García, additional, Figueroa, Angélica, additional, Fontoira, Lydia Fraga, additional, Franco, Carlos M.N, additional, Gallardo-Gómez, María, additional, García, Concepción Crespo, additional, García, Esther Rodríguez, additional, García-López, Alba, additional, Garrido, Federico, additional, González, Javier Aguirrezabalaga, additional, González-Carreró, Joaquín, additional, Gonzalez-Rivas, Diego, additional, Graña-Suárez, Begoña, additional, Hernández, Vicent, additional, Higuero, Paula Peleteiro, additional, Iglesias, Héctor Lázare, additional, Lago, Orlando Fernández, additional, Lamas, Alexandre, additional, Liñares-Blanco, Jose, additional, Llanas, María Jose Martinez-Sapiña, additional, López, Fernando Fernández, additional, López, José Ramón Antúnez, additional, López-López, Rafael, additional, López-Novo, Anael, additional, Lorenzo, Carmen Álvarez, additional, Loureiro, Miguel Pereira, additional, Macenlle García, Ramiro Manuel, additional, Maldonado, Shirly Margarita Nieves, additional, Marcos, Sara Seijas, additional, Marqués, Eva Martí, additional, Martín, Cristina González, additional, Martínez, Arantza Germade, additional, Martínez Lago, Nieves, additional, Martínez-Bernal, Gala, additional, Martínez-Pérez, Julia, additional, Mato-Abad, Virginia, additional, Méndez, Silvia Louzao, additional, Montalvo, Manuel Bustamante, additional, Mosquera, Beatriz Romero, additional, Muñoz, Catuxa Celeiro, additional, Munteanu, Cristian R., additional, Nine, Ángel Concheiro, additional, Novoa, Alejandra García, additional, Oreiro, Martina Lema, additional, Osuna, Francisco Ruíz-Cabello, additional, Otero, María, additional, Otero Muinelo, Susana A., additional, Parada, Pilar Díaz, additional, Paredes Cotoré, Jesús P., additional, Pazos, Alejandro, additional, Pazos García, Alejandro, additional, Pazos García, Carla, additional, Pedreira, Nieves, additional, Pillado, María Teresa Seoane, additional, Piñeiro, Susana López, additional, Poza, Margarita, additional, Purriños, Natalia Cal, additional, Queipo, Francisco, additional, Regal, Patricia, additional, Reinquet, Fernando Zelaya, additional, Rey, María Teresa Vázquez, additional, Rivas, Andrés Dacal, additional, Rocha, José Luis Ulla, additional, Rodríguez, Alejandro Ledo, additional, Rodríguez, Francisco Javier González, additional, Rodríguez, Gerardo Baños, additional, Rodríguez, María Teresa García, additional, Rodríguez, Máximo Fraga, additional, Rojas, Miriam, additional, Rosés, Leopoldo López, additional, Rúa, Marta Covela, additional, Ruiz-Bañobre, Juan, additional, Ruiz-Ponte, Clara, additional, Saavedra, Francisco Javier Maestro, additional, Sacristán Santos, Víctor, additional, Said-Criado, Ismael, additional, Sánchez, Aliuska Duardo, additional, Santamaría, Paloma González, additional, Sardenberg, Rodrigo A.S., additional, Sieira, Antonio Jurjo, additional, Silva, Paulino Pais, additional, Suarez, Rosa Fungueiriño, additional, Taboada, Tatiana María Civeira, additional, Trillo, Adriana Barreiro, additional, Trillo, Rosa, additional, Vázquez-Tunas, M. Lidia, additional, Turnes, Alfonso Martínez, additional, Valladares, Begoña Taboada, additional, Valladares-Ayerbes, Manuel, additional, Varela, Vanesa Val, additional, Varela-Calviño, Rubén, additional, Vázquez, Beatriz I., additional, Vázquez, Carla Blanco, additional, Vázquez, Juan Turnes, additional, Vázquez, Pablo Parada, additional, Vázquez, Vanesa Vilanova, additional, Vázquez-Naya, José M., additional, Vázquez-Rivera, Francisca, additional, Veiga, Alberto, additional, Vidal-Ínsua, Yolanda, additional, Vilas, Alba María Arceo, additional, and Worner, Ignacio Couto, additional

Published
2022
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12. Contributors

Author

Abriouel, Hikmate, primary, Almeida, Milena Evangelista, additional, Barbosa, Joana Cristina, additional, Benomar, Nabil, additional, Bernardes, Andressa Ladeira, additional, Bressan, Josefina, additional, Calatayud, Guillermo Álvarez, additional, Callou, Kátia Rau de Almeida, additional, Campos, Débora A., additional, Cardelle-Cobas, Alejandra, additional, Cassani, Lucía, additional, Castro, Joice da Silva, additional, Cepeda, Alberto, additional, Chaudhary, Nisha, additional, Chaudhary, Vandana, additional, Chieffi, Daniele, additional, Cruz Neto, José Patrocínio Ribeiro, additional, da Costa, Whyara Karoline Almeida, additional, Dangi, Priya, additional, da Silva, Alda Cássia Alves, additional, da Silva, Moisés Tolentino Bento, additional, de Brito Alves, José Luiz, additional, de Moura e Dias, Mariana, additional, de Oliveira, Maria Elieidy Gomes, additional, de Souza, Evandro Leite, additional, de Souza, Eliana Carla Gomes, additional, dos Santos, Carolina Araújo, additional, dos Santos Cruz, Bruna Cristina, additional, De Simone, Claudio, additional, Dejani, Naiara Naiana, additional, Dewan, Aastha, additional, Fanelli, Francesca, additional, Fusco, Vincenzina, additional, Gerbino, Esteban, additional, Gomes, Ana Maria, additional, Gomes, Aline Corado, additional, Gómez-Zavaglia, Andrea, additional, Hassan, Hadeel, additional, Hoffmann, Christian, additional, Joshi, Shourabh, additional, Katia, Sivieri, additional, Lacerda, Diego Cabral, additional, Lamas, Alexandre, additional, Loureiro, Laís Monteiro Rodrigues, additional, Machado, Daniela, additional, Majhenič, Andreja Čanžek, additional, Marazzato, Massimiliano, additional, Marciane, Magnani, additional, Marzet, Christian Boggio, additional, Matijašić, Bojana Bogovič, additional, Melgaço, Ana Clara Correia, additional, Meurman, Jukka, additional, Milagro, Fermin I., additional, Miranda, Jose Manuel, additional, Moreno-Indias, Isabel, additional, Mota, João Felipe, additional, Paulino do Nascimento, Luciana Caroline, additional, Paveljšek, Diana, additional, Peluzio, Maria do Carmo Gouveia, additional, Pereira, Irislene Costa, additional, Pereira, Mariana de Fátima Albuquerque, additional, Pessoa, Wallace Felipe Blohem, additional, Pimentel, Tatiana Colombo, additional, Pintado, Manuela, additional, Ribeiro, Andréia Queiroz, additional, Romano, Carla Cristina, additional, Rosa, Carla de Oliveira Barbosa, additional, Sablania, Vandana, additional, Sampaio, Karoliny Brito, additional, Santos, Thalis Ferreira, additional, Severo, Juliana Soares, additional, Siddqui, Saleem, additional, Sinisterra-Loaiza, Laura I., additional, Stamatova, Iva, additional, Sônia Mariza Luiz, de Oliveira, additional, Tammy Priscilla Chioda, Delfino, additional, Tinahones, Francisco J., additional, Torres-Leal, Francisco Leonardo, additional, Trabazo, Rosaura Leis, additional, Treven, Primož, additional, Trindade da Costa, Paulo César, additional, Voss, Glenise Bierhalz, additional, and Yadav, Ajar Nath, additional

Published
2022
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13. Contributors

Author

Agregán, Rubén, primary, Aleu, Gonzalo, additional, Alves, Susana P., additional, Astray, Gonzalo, additional, Barba, Francisco J., additional, Berrada, Houda, additional, Bohrer, Benjamin M., additional, Campagnol, Paulo Cezar Bastianello, additional, Cantalapiedra, Jesús, additional, Cardelle-Cobas, Alejandra, additional, Cepeda, Alberto, additional, Cichoski, Alexandre José, additional, Cittadini, Aurora, additional, Conte-Junior, Carlos A., additional, Costa, Patricia, additional, de Menezes, Cristiano Ragagnin, additional, del Río, Pablo G., additional, Derewiaka, Dorota, additional, Domínguez, Rubén, additional, Echegaray, Noemí, additional, Ferrer, Emilia, additional, Franco, Daniel, additional, Garrote, Gil, additional, Gullón, Beatriz, additional, Heck, Rosane Teresinha, additional, Jerónimo, Eliana, additional, López-Pedrouso, María, additional, Lorenzo, José M., additional, Munekata, Paulo Eduardo Sichetti, additional, Nawaz, Asad, additional, Nebot, Carolina, additional, Nieto, Gema, additional, Oliveira, Diana, additional, Pallarés, Noelia, additional, Pateiro, Mirian, additional, Pérez-Álvarez, José Ángel, additional, Popova, Teodora, additional, Purriños, Laura, additional, Rosmini, Marcelo R., additional, Ruiz-Capillas, Claudia, additional, Santos, Bibiana Alves Dos, additional, Santos, Eva M., additional, Sarriés, María V., additional, Sosa-Morales, María Elena, additional, Teixeira, Alfredo, additional, Vázquez, Beatriz, additional, Walayat, Noman, additional, Wang, Min, additional, Zamuz, Sol, additional, and Zhou, Jianjun, additional

Published
2022
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14. Effects of Dietary Inclusion of Saccharina latissima and Ulva lactuca on Growth Performance and Gut Health in Growing Rabbits.

Author

Al-Soufi, Sabela, Losada, Ana Paula, López-Alonso, Marta, Cardelle-Cobas, Alejandra, Mora, Azucena, Lamas, Alexandre, Panadero, Rosario, Miranda, Marta, Muíños, Antonio, Cegarra, Eugenio, and García, Javier

Subjects
INTESTINAL barrier function, GUT microbiome, RABBIT diseases, RABBIT meat, TIGHT junctions
Abstract

Rabbit meat production faces challenges due to the prevalence of gastrointestinal diseases in rabbits, exacerbated by restrictions on antibiotic use in European animal production. Marine macroalgae, rich in bioactive compounds such as soluble polysaccharides, represent promising solutions to this problem. However, research on the effects of macroalgae and the underlying mechanisms in rabbits is limited, especially in commercial settings. This study aimed to evaluate the impact of Saccharina latissima (dehydrated) and Ulva lactuca (dehydrated and hydrolyzed extract) on rabbit on growth performance and gut health in a commercial farm context. A total of 96 litters (8 rabbits/litter) of crossbred rabbits weaned at 33 days of age were randomly assigned to 4 experimental groups (control, Saccharina latissima dehydrated, Ulva lactuca dehydrated and Ulva lactuca hydrolyzed extract; 24 replicates/treatment) and monitored from weaning to slaughter at 61 days of age. The key indicators of gut health were assessed 14 days post-weaning by counting coccidia, isolating specific microflora and examining histological samples. Additionally, the relevant intestinal markers (microbiome composition, mucin content and gene expression related to immune response and tight junction proteins) were determined in order to elucidate the potential mechanisms involved. The inclusion of macroalgae in the diet did not influence growth performance of the animals. S. latissima had a positive effect in reducing coccidia counts (p = 0.10) and improving mucosal morphology (p < 0.001), which can possibly be attributed to modulation of the microbiota and improved mucosal functionality. Ulva lactuca had a favorable effect on gut tight junction proteins (p < 0.001), enhancing intestinal barrier function. These findings suggest the potential of macroalgae to modify the intestinal microbiome by reducing the presence of inflammatory bacteria. Further research is warranted to elucidate the mechanisms involved and optimize macroalgae supplementation in rabbit nutrition for enhanced gut health. [ABSTRACT FROM AUTHOR]

Published
2024
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16. ACE-Inhibitory Activity of Whey Proteins Fractions Derived of Fermentation by Lacticaseibacillus rhamnosus GG and Streptococcus thermophilus SY-102

Author

Olvera-Rosales, Laura Berenice, primary, Pérez-Escalante, Emmanuel, additional, Castañeda-Ovando, Araceli, additional, Contreras-López, Elizabeth, additional, Cruz-Guerrero, Alma Elizabeth, additional, Regal-López, Patricia, additional, Cardelle-Cobas, Alejandra, additional, and González-Olivares, Luis Guillermo, additional

Published
2023
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29. Effects of Unconventional Work and Shift Work on the Human Gut Microbiota and the Potential of Probiotics to Restore Dysbiosis.

Author

Lopez-Santamarina, Aroa, Mondragon, Alicia del Carmen, Cardelle-Cobas, Alejandra, Santos, Eva Maria, Porto-Arias, Jose Julio, Cepeda, Alberto, and Miranda, Jose Manuel

Abstract

The work environment is a factor that can significantly influence the composition and functionality of the gut microbiota of workers, in many cases leading to gut dysbiosis that will result in serious health problems. The aim of this paper was to provide a compilation of the different studies that have examined the influence of jobs with unconventional work schedules and environments on the gut microbiota of workers performing such work. As a possible solution, probiotic supplements, via modulation of the gut microbiota, can moderate the effects of sleep disturbance on the immune system, as well as restore the dysbiosis produced. Rotating shift work has been found to be associated with an increase in the risk of various metabolic diseases, such as obesity, metabolic syndrome, and type 2 diabetes. Sleep disturbance or lack of sleep due to night work is also associated with metabolic diseases. In addition, sleep disturbance induces a stress response, both physiologically and psychologically, and disrupts the healthy functioning of the gut microbiota, thus triggering an inflammatory state. Other workers, including military, healthcare, or metallurgy workers, as well as livestock farmers or long-travel seamen, work in environments and schedules that can significantly affect their gut microbiota. [ABSTRACT FROM AUTHOR]

Published
2023
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31. A2 Milk: New Perspectives for Food Technology and Human Health

Author

Fernández-Rico, Salvador, primary, Mondragón, Alicia del Carmen, additional, López-Santamarina, Aroa, additional, Cardelle-Cobas, Alejandra, additional, Regal, Patricia, additional, Lamas, Alexandre, additional, Ibarra, Israel Samuel, additional, Cepeda, Alberto, additional, and Miranda, José Manuel, additional

Published
2022
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32. Nutritional composition, heavy metal content and in vitro effect on the human gut microbiota of Talitrus saltator, an underutilized crustacean from the Atlantic coast

Author

Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía, López Santamarina, Aroa, Cardelle Cobas, Alejandra, Lamas Freire, Alexandre, Mondragón Portocarrero, Alicia del Carmen, Cepeda Sáez, Alberto, Miranda López, Jose Manuel, Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía, López Santamarina, Aroa, Cardelle Cobas, Alejandra, Lamas Freire, Alexandre, Mondragón Portocarrero, Alicia del Carmen, Cepeda Sáez, Alberto, and Miranda López, Jose Manuel

Abstract

In this study, an undervalued marine crustacean (Talitrus saltator) was characterized in terms of nutritional and heavy metal composition and its potential to affect human gut microbiota. Nutritional analysis of this crustacean revealed that it complies with the criteria established in European legislation to include nutritional claims in their labeling, such as “source of fiber,” “low in fat,” “low in sugars” and “high in protein.” The analysis of the heavy metal content did not reveal any risk derived from the presence of Cd, Hg, or Pb, whereas essential metals contained in 100 g exceeded the minimum daily requirements recommended in Europe for Zn (19.78 mg/kg), Cu (2.28 mg/kg), and Fe (32.96 mg/kg). Using an in vitro system, the effect of T. saltator on the human colonic microbiota shows some beneficial effects, such as fermentation-maintained populations of Bifidobacterium or Lactobacillus, did not increase Firmicutes phylum counts, decreased the Firmicutes/Bacteroidetes ratio, and stimulated 11 metabolic pathways with respect to baseline. These results are unusual in a high protein content-food. However, negative effects were also found in gut microbiota relative proportions, such as an increase in the Proteobacteria phylum and especially some opportunistic bacteria from this phylum, probably due to the antimicrobial effect of chitin on other groups more sensitive to its effect. This work shows for the first time the effect of T. saltator on human colonic microbiota using and in vitro system. The presence of chitin in its composition could provide some beneficial effects by modulating the microbiota, but as T. saltator is a high-protein food, more studies should be carried out showing these benefit

Published
2022

33. Evaluation of the potential prebiotic effect of Himanthalia elongata, an Atlantic brown seaweed, in an in vitro model of the human distal colon

Author

Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía, Universidade de Santiago de Compostela. Facultade de Veterinaria, López Santamarina, Aroa, Cardelle Cobas, Alejandra, Mondragón Portocarrero, Alicia del Carmen, Sinisterra Loaiza, Laura Isabel, Miranda López, José Manuel, Cepeda Sáez, Alberto, Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía, Universidade de Santiago de Compostela. Facultade de Veterinaria, López Santamarina, Aroa, Cardelle Cobas, Alejandra, Mondragón Portocarrero, Alicia del Carmen, Sinisterra Loaiza, Laura Isabel, Miranda López, José Manuel, and Cepeda Sáez, Alberto

Abstract

Until now, although different studies have shown the potential prebiotic effect of seaweed carbohydrates, no studies with the whole seaweeds have been carried out. In addition, the prebiotic effect throughput sequencing remains poorly investigated since most of the published works used qPCR or FISH to estimate bacterial changes. In this work, an in vitro model of the human distal colon was used to determine, for the first time, the potential prebiotic effect of a brown whole seaweed Himanthalia elongata. The whole seaweed was characterized in basis of its nutritional and mineral composition and submitted to the entire gastrointestinal digestion. The prebiotic effect was evaluated by the microbial modulation through 16S rRNA amplicon sequencing, qPCR and short-chain fatty acid analysis. The obtained results indicated that the colonic fraction of H. elongata was used selectively by the Bacteroides genus, more specifically by the specie Bacteoides ovatus, whereas inulin was used mainly by the Parabacteroides genus, being Parabacteroides distasonis the most abundant identified specie. Selective use of inulin by P. distasonis is, therefore, reported by the first time. qPCR analysis shown no significative differences in Bifidobacterium population and a decrease in Lactobacillus along the fermentation assays with both substrates. Regarding to the short-fatty acid production, maximal concentration, 56.11 ± 20.48 mM, was achieved for H. elongata, at 24 h of fermentation whereas for inulin total acid production was 93.66 ± 21.82 mM at 48 h of assay. The metabolic pathways associated with bacterial genera were not significantly different between the two tested substrates. Although more studies are necessary to elucidate the prebiotic character of H. elongata, the results presented in this work are promissory and could open new opportunities of research and application in the area of Nutrition and Food Chemistry

Published
2022

39. sj-docx-1-nah-10.1177_02601060221127115 - Supplemental material for Changes in lifestyle behaviors during COVID-19 isolation in Argentina: A cross-sectional study

Author

Flores, Luis E., Elgart, Jorge F., Abraham, Analía G., Garrote, Graciela L., Torrieri, Rocío, Cepeda, Alberto, Cardelle-Cobas, Alejandra, and Gagliardino, Juan J.

Subjects
111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-nah-10.1177_02601060221127115 for Changes in lifestyle behaviors during COVID-19 isolation in Argentina: A cross-sectional study by Luis E. Flores, Jorge F. Elgart, Analía G. Abraham, Graciela L. Garrote, Rocío Torrieri, Alberto Cepeda, Alejandra Cardelle-Cobas and Juan J. Gagliardino in Nutrition and Health

Published
2022
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41. Identification and Quantification of 29 Active Substances by HPLC–ESI-MS/MS in Lyophilized Swine Manure Samples.

Author

Nebot, Carolina, Cardelle-Cobas, Alejandra, García-Presedo, Ignacio, Patyra, Ewelina, Cepeda, Alberto, and Franco, Carlos M.

Subjects
*SWINE manure, *MANURES, *VETERINARY drugs, *ANTIPARASITIC agents, *DRUG administration, *ANIMAL health, *ANTIBIOTICS
Abstract

Veterinary drugs are frequently employed to treat and prevent diseases in food-producing animals to improve animal health and to avoid the introduction of microorganisms into the food chain. The analysis of the presence of pharmaceutical residues in animal manure could help to evaluate the legal and illegal practices during food production without harming the animals and to correctly manage manure when it is going to be applied as a fertilizer. This article describes a method for the simultaneous analysis of 29 active substances, mostly antibiotics and antiparasitic agents. Substances were extracted from lyophilized manure with a methanol:McIlvaine solution and analyzed with HPLC–ESI-MS/MS and a C18 HPLC column. The method was validated following European guidelines, the achieved trueness was between 63 and 128% (depending on the analytes), and the linearity was between 100 and 1500 µg/kg. The applicability of the method was demonstrated in 40 manure samples collected from pig farms where tetracycline was quantified in 7.5% of the samples. These results show the viability of this non-invasive method for the control of the legal and illegal administration of pharmaceuticals in food-producing animals. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Supplementary material.docx

Author

Cardelle Cobas, Alejandra, Lopez-Santamarina, Aroa, Mirnada, Jose Manuel, Cepeda Saez, Alberto, Sinisterra-Loaiza, Laura, and Mondrag��n, Alicia

Abstract

Supplementary materialManuscript:Evaluation of the potential prebiotic effect of Himanthalia elongata, an Atlantic brown seaweed, in an in vitro model of the human distal colonJournal of food and bioprocess Technology

Published
2021
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45. Effects of a green seaweed from the Atlantic coast (Ulva lactuca)on gut microbiota, using an in vitrocolon model

Author

López-Santamarina, Aroa, Roade-Pérez, Paula, Mondragón-Portocarrero, Alicia del Carmen, Cardelle-Cobas, Alejandra, Cepeda, Alberto, and Miranda, José Manuel

Abstract

Recently, it has been seen that carbohydrates from seaweeds can modify the composition of the gut microbiota and stimulate the production of short chain fatty acids. Seaweed as an interesting alternative to animal protein and possesses, in addition to these carbohydrates, other bioactive components of interest. For this reason, we evaluated the effects of the whole green seaweed Ulva lactucaon the intestinal with in vitrocolonic simulation. Proximate analysis showed that U. lactucais rich in fibre and calcium. In addition, in vitrocolonic fermentation of this seaweed indicated that it could be used as a carbon source by the gut microbiota; it did not show significant differences in amplicon sequence variants compared with inulin fermentation. Compared with the negative control, the predominant bacterial species after fermentation of U. lactucawere Parabacteroides distasonisand Bacteroides ovatus. Moreover, although to a lesser extent than did inulin, fermentation of U. lactucastimulated the production of short-chain fatty acids. Regarding to the metabolic pathways, statistical differences were found among assays, founding 11 pathways increased for the assays with U. lactuca(e.g. PWY-5507 or TOMCAT-PWY, among other 8 and 2 for those developed with inulin (PWY-5304 and PWY-6572). Although more studies are necessaries to confirm the positive effect of U. lactucaon the human gut microbiota, this study showed that it has a similar behaviour to inulin, opening new opportunities to investigate the effects of consumption of this whole seaweed in the human health.

Published
2025
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46. Probiotic Effects against Virus Infections: New Weapons for an Old War

Author

Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía, López Santamarina, Aroa, Lamas Freire, Alexandre, Mondragón Portocarrero, Alicia del Carmen, Cardelle Cobas, Alejandra, Regal López, Patricia, Rodríguez Ávila, José Antonio, Miranda López, José Manuel, Franco Abuín, Carlos Manuel, Cepeda Sáez, Alberto, Universidade de Santiago de Compostela. Departamento de Química Analítica, Nutrición e Bromatoloxía, López Santamarina, Aroa, Lamas Freire, Alexandre, Mondragón Portocarrero, Alicia del Carmen, Cardelle Cobas, Alejandra, Regal López, Patricia, Rodríguez Ávila, José Antonio, Miranda López, José Manuel, Franco Abuín, Carlos Manuel, and Cepeda Sáez, Alberto

Abstract

This review aimed to gather the available literature investigating the effects of probiotics against the most common viral infections using in vitro trials in cell lines and in vivo clinical trials in both experimental animals and humans. Probiotics were employed to prevent and reduce symptoms of infections caused by common viruses, especially respiratory tract viruses, but also for viral digestive infections (such as rotavirus, coronavirus, or norovirus) and other viral infections (such as viruses that cause hepatitis, human papillomavirus, human immunodeficiency virus, and herpes simplex virus). Different probiotics have been studied to see their possible effect against the abovementioned viruses, among which different Lactobacillus species, Bifidobacterium, Clostridium, Enterococcus, and Streptococcus can be highlighted. In many cases, mixtures of various probiotic strains were used. Although the results obtained did not show similar results, in most cases, probiotic supplementation improved both barrier and biochemical immune responses, decreased susceptibility to viral infections, and enhanced the effects of concomitant vaccines. Works collected in this review show a beneficial effect of probiotics in the prevention and treatment of different viral infections. We found interesting results related to the prevention of viral infections, reduction of the duration of diseases, and decrease of symptoms

Published
2021

47. Probiotic Effects against Virus Infections: New Weapons for an Old War

Author

Lopez-Santamarina, Aroa, primary, Lamas, Alexandre, additional, del Carmen Mondragón, Alicia, additional, Cardelle-Cobas, Alejandra, additional, Regal, Patricia, additional, Rodriguez-Avila, José Antonio, additional, Miranda, José Manuel, additional, Franco, Carlos Manuel, additional, and Cepeda, Alberto, additional

Published
2021
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48. Influence of the Intestinal Microbiota on Diabetes Management

Author

Alvarez-Vieites, Eva, primary, López-Santamarina, Arora, additional, Miranda, José M., additional, del Carmen Mondragón, Alicia, additional, Lamas, Alexandre, additional, Cardelle-Cobas, Alejandra, additional, Nebot, Carolina, additional, Franco, Carlos M., additional, and Cepeda, Alberto, additional

Published
2020
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49. Low fat goat meat sausage with chitosan-glucose Maillard reaction product: impact on quality and shelf life

Author

AMARAL, Deborah Silva do, primary, CARDELLE-COBAS, Alejandra, additional, DIAS, Celina de Castro Querino, additional, LIMA, Darlinne Amanda Soares, additional, PEREIRA, Sérgio de Ferreira, additional, ARCANJO, Naciza Maria de Oliveira, additional, DALMÁS, Paulo Sérgio, additional, MADRUGA, Marta Suely, additional, and PINTADO, Maria Manuela Estevez, additional

Published
2020
Full Text
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