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1. Therapeutic Management of Patients with FLT3 + Acute Myeloid Leukemia: Case Reports and Focus on Gilteritinib Monotherapy

Author

Bocchia M, Carella AM, Mulè A, Rizzo L, Turrini M, Abbenante MC, Cairoli R, Calafiore V, Defina M, Gardellini A, Luzi G, Patti C, Pinazzi MB, Riva M, Rossi G, Sammartano V, and Rigacci L

Subjects
acute myeloid leukemia, flt3, midostaurin, gilteritinib, Therapeutics. Pharmacology, RM1-950
Abstract

Monica Bocchia,1 Angelo Michele Carella,2 Antonino Mulè,3 Lorenzo Rizzo,4 Mauro Turrini,5 Maria Chiara Abbenante,2 Roberto Cairoli,4 Valeria Calafiore,3 Marzia Defina,1 Angelo Gardellini,5 Giovanni Luzi,6 Caterina Patti,3 Maria Beatrice Pinazzi,6 Marta Riva,4 Giovanni Rossi,2 Vincenzo Sammartano,1 Luigi Rigacci6 1Hematology Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy; 2Division of Hematology with Hematologic Intensive Care Unit and Cellular Therapies, Department of Medical Science, Fondazione IRCCS Casa Sollievo Della Sofferenza, Foggia, Italy; 3UOC Hematology and Oncology, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy; 4Department of Haematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy; 5Division of Hematology, Valduce Hospital, Como, Italy; 6UOC Hematology and Stem Cell Transplant Unit, Ospedale S, Camillo, Rome, ItalyCorrespondence: Angelo Michele Carella, Division of Hematology with Hematologic Intensive Care Unit and Cellular Therapies, Department of Medical Science, Fondazione IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, San Giovanni Rotondo, Foggia, 71013, Italy, Tel +390882410054, Fax +390882410322, Email am.carella@operapadrepio.itAbstract: Acute myeloid leukemia is a malignant disorder of the bone marrow, characterized by differentiation, clonal expansion, and uncontrolled proliferation of malignant myeloid progenitor cells and by several molecular and genetic abnormalities. A mutation of FMS-like tyrosine kinase 3 gene can be observed in about one-third of cases of acute myeloid leukemia. Two FLT3 inhibitors are actually approved for FLT3 mutated acute myeloid leukemia: midostaurin, a multikinase first generation inhibitor with lower affinity for FLT3 binding, and gilteritinib fumarate, a potent second-generation inhibitor of both FLT3-ITD and TKD. Gilteritinib is a new effective and well-tolerated drug for patients with relapsing or refractory FLT3-positive acute myeloid leukemia. Thanks to its efficacy, low toxicity, its good manageability (oral formulation), this drug is suitable for all the patients, including elderly frail patient with concomitant therapies or pre-existing or underlying diseases, and can be used also in the outpatient setting, reducing risks and costs related to the hospitalization. We report and discuss seven cases of different patients with FLT3 positive acute myeloid leukemia successfully managed with gilteritinib in the real clinical practice.Keywords: acute myeloid leukemia, FLT3, midostaurin, gilteritinib

Published
2022

2. Density of Squarefree Totients $p-1$ and Primitive Roots

Author

Carella, N. A.

Subjects
Mathematics - General Mathematics, Primary 11A07, Secondary 11N05
Abstract

This note determines an effective asymptotic formula for the number of squarefree totients $p-1$ with a fixed primitive root $u\ne \pm 1, v^2$., Comment: Twenty Pages. Keywords: Primitive root; Squarefree totient; Distribution of primes. arXiv admin note: text overlap with arXiv:2106.00544

Published
2024

3. Euclid preparation. Simulations and nonlinearities beyond $\Lambda$CDM. 2. Results from non-standard simulations

Author

Euclid Collaboration, Rácz, G., Breton, M. -A., Fiorini, B., Brun, A. M. C. Le, Winther, H. -A., Sakr, Z., Pizzuti, L., Ragagnin, A., Gayoux, T., Altamura, E., Carella, E., Pardede, K., Verza, G., Koyama, K., Baldi, M., Pourtsidou, A., Vernizzi, F., Adame, A. G., Adamek, J., Avila, S., Carbone, C., Despali, G., Giocoli, C., Hernández-Aguayo, C., Hassani, F., Kunz, M., Li, B., Rasera, Y., Yepes, G., Gonzalez-Perez, V., Corasaniti, P. -S., García-Bellido, J., Hamaus, N., Kiessling, A., Marinucci, M., Moretti, C., Mota, D. F., Piga, L., Pisani, A., Szapudi, I., Tallada-Crespí, P., Aghanim, N., Andreon, S., Baccigalupi, C., Bardelli, S., Bonino, D., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Capobianco, V., Cardone, V. F., Carretero, J., Casas, S., Castellano, M., Castignani, G., Cavuoti, S., Cimatti, A., Colodro-Conde, C., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Courbin, F., Courtois, H. M., Da Silva, A., Degaudenzi, H., De Lucia, G., Douspis, M., Dubath, F., Duncan, C. A. J., Dupac, X., Dusini, S., Ealet, A., Farina, M., Farrens, S., Ferriol, S., Fosalba, P., Frailis, M., Franceschi, E., Fumana, M., Galeotta, S., Gillis, B., Gómez-Alvarez, P., Grazian, A., Grupp, F., Haugan, S. V. H., Holmes, W., Hormuth, F., Hornstrup, A., Ilić, S., Jahnke, K., Jhabvala, M., Joachimi, B., Keihänen, E., Kermiche, S., Kilbinger, M., Kitching, T., Kubik, B., Kurki-Suonio, H., Lilje, P. B., Lindholm, V., Lloro, I., Mainetti, G., Maiorano, E., Mansutti, O., Marggraf, O., Markovic, K., Martinelli, M., Martinet, N., Marulli, F., Massey, R., Medinaceli, E., Mei, S., Mellier, Y., Meneghetti, M., Meylan, G., Moresco, M., Moscardini, L., Niemi, S. -M., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Percival, W. J., Pettorino, V., Pires, S., Polenta, G., Poncet, M., Popa, L. A., Raison, F., Rebolo, R., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Roncarelli, M., Saglia, R., Salvignol, J. -C., Sánchez, A. G., Sapone, D., Sartoris, B., Schirmer, M., Schrabback, T., Secroun, A., Seidel, G., Serrano, S., Sirignano, C., Sirri, G., Stanco, L., Steinwagner, J., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valenziano, L., Vassallo, T., Kleijn, G. Verdoes, Wang, Y., Weller, J., Zucca, E., Biviano, A., Boucaud, A., Bozzo, E., Burigana, C., Calabrese, M., Di Ferdinando, D., Vigo, J. A. Escartin, Fabbian, G., Finelli, F., Gracia-Carpio, J., Matthew, S., Mauri, N., Pezzotta, A., Pöntinen, M., Porciani, C., Scottez, V., Tenti, M., Viel, M., Wiesmann, M., Akrami, Y., Allevato, V., Anselmi, S., Archidiacono, M., Atrio-Barandela, F., Balaguera-Antolinez, A., Ballardini, M., Bertacca, D., Blot, L., Borgani, S., Bruton, S., Cabanac, R., Calabro, A., Quevedo, B. Camacho, Cappi, A., Caro, F., Carvalho, C. S., Castro, T., Chambers, K. C., Contarini, S., Cooray, A. R., De Caro, B., de la Torre, S., Desprez, G., Díaz-Sánchez, A., Diaz, J. J., Di Domizio, S., Dole, H., Escoffier, S., Ferrari, A. G., Ferreira, P. G., Ferrero, I., Fontana, A., Fornari, F., Gabarra, L., Ganga, K., Gasparetto, T., Gaztanaga, E., Giacomini, F., Gianotti, F., Gozaliasl, G., Gutierrez, C. M., Hall, A., Hildebrandt, H., Hjorth, J., Muñoz, A. Jimenez, Kajava, J. J. E., Kansal, V., Karagiannis, D., Kirkpatrick, C. C., Lacasa, F., Graet, J. Le, Legrand, L., Lesgourgues, J., Liaudat, T. I., Loureiro, A., Macias-Perez, J., Maggio, G., Magliocchetti, M., Mannucci, F., Maoli, R., Martins, C. J. A. P., Maurin, L., Metcalf, R. B., Miluzio, M., Monaco, P., Montoro, A., Mora, A., Morgante, G., Nadathur, S., Walton, Nicholas A., Patrizii, L., Popa, V., Potter, D., Reimberg, P., Risso, I., Rocci, P. -F., Sahlén, M., Schneider, A., Sereno, M., Silvestri, A., Mancini, A. Spurio, Stadel, J., Tanidis, K., Tao, C., Tessore, N., Testera, G., Teyssier, R., Toft, S., Tosi, S., Troja, A., Tucci, M., Valieri, C., Valiviita, J., Vergani, D., and Vielzeuf, P.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The Euclid mission will measure cosmological parameters with unprecedented precision. To distinguish between cosmological models, it is essential to generate realistic mock observables from cosmological simulations that were run in both the standard $\Lambda$-cold-dark-matter ($\Lambda$CDM) paradigm and in many non-standard models beyond $\Lambda$CDM. We present the scientific results from a suite of cosmological N-body simulations using non-standard models including dynamical dark energy, k-essence, interacting dark energy, modified gravity, massive neutrinos, and primordial non-Gaussianities. We investigate how these models affect the large-scale-structure formation and evolution in addition to providing synthetic observables that can be used to test and constrain these models with Euclid data. We developed a custom pipeline based on the Rockstar halo finder and the nbodykit large-scale structure toolkit to analyse the particle output of non-standard simulations and generate mock observables such as halo and void catalogues, mass density fields, and power spectra in a consistent way. We compare these observables with those from the standard $\Lambda$CDM model and quantify the deviations. We find that non-standard cosmological models can leave significant imprints on the synthetic observables that we have generated. Our results demonstrate that non-standard cosmological N-body simulations provide valuable insights into the physics of dark energy and dark matter, which is essential to maximising the scientific return of Euclid., Comment: 22 pages, 7 figures

Published
2024

4. Room-temperature optical spin polarization of an electron spin qudit in a vanadyl -- free base porphyrin dimer

Author

Privitera, Alberto, Chiesa, Alessandro, Santanni, Fabio, Carella, Angelo, Ranieri, Davide, Caneschi, Andrea, Krzyaniak, Matthew D., Young, Ryan M., Wasielewski, Michael R., Carretta, Stefano, and Sessoli, Roberta

Subjects
Quantum Physics, Physics - Chemical Physics
Abstract

Photoexcited organic chromophores appended to molecular qubits can serve as a source of spin initialization or multi-level qudit generation for quantum information applications. So far, this approach has been primarily investigated in chromophore/stable radical systems. Here, we extend this concept to a meso-meso linked oxovanadium(IV) porphyrin - free base porphyrin dimer. Femtosecond transient absorption experiments reveal that photoexcitation of the free base porphyrin leads to picosecond triplet state formation via enhanced intersystem crossing. Time-resolved electron paramagnetic resonance (TREPR) experiments carried out at both 85 K and room temperature reveal the formation of a long-lived spin-polarized quartet state through triplet-doublet spin mixing. Notably, a distinct hyperfine structure arising from the interaction between the electron spin quartet state and the vanadyl nucleus (51V, I=7/2) is evident, with the quartet state exhibiting long-lived spin polarization even at room temperature. Theoretical simulations of the TREPR spectra confirm the photogenerated quartet state and provide insights into the non-Boltzmann spin populations. Exploit-ing this phenomenon affords the possibility of using photoinduced triplet states in porphyrins for quantum information as a resource to polarize and magnetically couple molecular electronic or nuclear spin qubits and qudits.

Published
2024

5. Euclid. I. Overview of the Euclid mission

Author

Euclid Collaboration, Mellier, Y., Abdurro'uf, Barroso, J. A. Acevedo, Achúcarro, A., Adamek, J., Adam, R., Addison, G. E., Aghanim, N., Aguena, M., Ajani, V., Akrami, Y., Al-Bahlawan, A., Alavi, A., Albuquerque, I. S., Alestas, G., Alguero, G., Allaoui, A., Allen, S. W., Allevato, V., Alonso-Tetilla, A. V., Altieri, B., Alvarez-Candal, A., Alvi, S., Amara, A., Amendola, L., Amiaux, J., Andika, I. T., Andreon, S., Andrews, A., Angora, G., Angulo, R. E., Annibali, F., Anselmi, A., Anselmi, S., Arcari, S., Archidiacono, M., Aricò, G., Arnaud, M., Arnouts, S., Asgari, M., Asorey, J., Atayde, L., Atek, H., Atrio-Barandela, F., Aubert, M., Aubourg, E., Auphan, T., Auricchio, N., Aussel, B., Aussel, H., Avelino, P. P., Avgoustidis, A., Avila, S., Awan, S., Azzollini, R., Baccigalupi, C., Bachelet, E., Bacon, D., Baes, M., Bagley, M. B., Bahr-Kalus, B., Balaguera-Antolinez, A., Balbinot, E., Balcells, M., Baldi, M., Baldry, I., Balestra, A., Ballardini, M., Ballester, O., Balogh, M., Bañados, E., Barbier, R., Bardelli, S., Baron, M., Barreiro, T., Barrena, R., Barriere, J. -C., Barros, B. J., Barthelemy, A., Bartolo, N., Basset, A., Battaglia, P., Battisti, A. J., Baugh, C. M., Baumont, L., Bazzanini, L., Beaulieu, J. -P., Beckmann, V., Belikov, A. N., Bel, J., Bellagamba, F., Bella, M., Bellini, E., Benabed, K., Bender, R., Benevento, G., Bennett, C. L., Benson, K., Bergamini, P., Bermejo-Climent, J. R., Bernardeau, F., Bertacca, D., Berthe, M., Berthier, J., Bethermin, M., Beutler, F., Bevillon, C., Bhargava, S., Bhatawdekar, R., Bianchi, D., Bisigello, L., Biviano, A., Blake, R. P., Blanchard, A., Blazek, J., Blot, L., Bosco, A., Bodendorf, C., Boenke, T., Böhringer, H., Boldrini, P., Bolzonella, M., Bonchi, A., Bonici, M., Bonino, D., Bonino, L., Bonvin, C., Bon, W., Booth, J. T., Borgani, S., Borlaff, A. S., Borsato, E., Bose, B., Botticella, M. T., Boucaud, A., Bouche, F., Boucher, J. S., Boutigny, D., Bouvard, T., Bouwens, R., Bouy, H., Bowler, R. A. A., Bozza, V., Bozzo, E., Branchini, E., Brando, G., Brau-Nogue, S., Brekke, P., Bremer, M. N., Brescia, M., Breton, M. -A., Brinchmann, J., Brinckmann, T., Brockley-Blatt, C., Brodwin, M., Brouard, L., Brown, M. L., Bruton, S., Bucko, J., Buddelmeijer, H., Buenadicha, G., Buitrago, F., Burger, P., Burigana, C., Busillo, V., Busonero, D., Cabanac, R., Cabayol-Garcia, L., Cagliari, M. S., Caillat, A., Caillat, L., Calabrese, M., Calabro, A., Calderone, G., Calura, F., Quevedo, B. Camacho, Camera, S., Campos, L., Canas-Herrera, G., Candini, G. P., Cantiello, M., Capobianco, V., Cappellaro, E., Cappelluti, N., Cappi, A., Caputi, K. I., Cara, C., Carbone, C., Cardone, V. F., Carella, E., Carlberg, R. G., Carle, M., Carminati, L., Caro, F., Carrasco, J. M., Carretero, J., Carrilho, P., Duque, J. Carron, Carry, B., Carvalho, A., Carvalho, C. S., Casas, R., Casas, S., Casenove, P., Casey, C. M., Cassata, P., Castander, F. J., Castelao, D., Castellano, M., Castiblanco, L., Castignani, G., Castro, T., Cavet, C., Cavuoti, S., Chabaud, P. -Y., Chambers, K. C., Charles, Y., Charlot, S., Chartab, N., Chary, R., Chaumeil, F., Cho, H., Chon, G., Ciancetta, E., Ciliegi, P., Cimatti, A., Cimino, M., Cioni, M. -R. L., Claydon, R., Cleland, C., Clément, B., Clements, D. L., Clerc, N., Clesse, S., Codis, S., Cogato, F., Colbert, J., Cole, R. E., Coles, P., Collett, T. E., Collins, R. S., Colodro-Conde, C., Colombo, C., Combes, F., Conforti, V., Congedo, G., Conseil, S., Conselice, C. J., Contarini, S., Contini, T., Conversi, L., Cooray, A. R., Copin, Y., Corasaniti, P. -S., Corcho-Caballero, P., Corcione, L., Cordes, O., Corpace, O., Correnti, M., Costanzi, M., Costille, A., Courbin, F., Mifsud, L. Courcoult, Courtois, H. M., Cousinou, M. -C., Covone, G., Cowell, T., Cragg, C., Cresci, G., Cristiani, S., Crocce, M., Cropper, M., Crouzet, P. E, Csizi, B., Cuby, J. -G., Cucchetti, E., Cucciati, O., Cuillandre, J. -C., Cunha, P. A. C., Cuozzo, V., Daddi, E., D'Addona, M., Dafonte, C., Dagoneau, N., Dalessandro, E., Dalton, G. B., D'Amico, G., Dannerbauer, H., Danto, P., Das, I., Da Silva, A., da Silva, R., Doumerg, W. d'Assignies, Daste, G., Davies, J. E., Davini, S., Dayal, P., de Boer, T., Decarli, R., De Caro, B., Degaudenzi, H., Degni, G., de Jong, J. T. A., de la Bella, L. F., de la Torre, S., Delhaise, F., Delley, D., Delucchi, G., De Lucia, G., Denniston, J., De Paolis, F., De Petris, M., Derosa, A., Desai, S., Desjacques, V., Despali, G., Desprez, G., De Vicente-Albendea, J., Deville, Y., Dias, J. D. F., Díaz-Sánchez, A., Diaz, J. J., Di Domizio, S., Diego, J. M., Di Ferdinando, D., Di Giorgio, A. M., Dimauro, P., Dinis, J., Dolag, K., Dolding, C., Dole, H., Sánchez, H. Domínguez, Doré, O., Dournac, F., Douspis, M., Dreihahn, H., Droge, B., Dryer, B., Dubath, F., Duc, P. -A., Ducret, F., Duffy, C., Dufresne, F., Duncan, C. A. J., Dupac, X., Duret, V., Durrer, R., Durret, F., Dusini, S., Ealet, A., Eggemeier, A., Eisenhardt, P. R. M., Elbaz, D., Elkhashab, M. Y., Ellien, A., Endicott, J., Enia, A., Erben, T., Vigo, J. A. Escartin, Escoffier, S., Sanz, I. Escudero, Essert, J., Ettori, S., Ezziati, M., Fabbian, G., Fabricius, M., Fang, Y., Farina, A., Farina, M., Farinelli, R., Farrens, S., Faustini, F., Feltre, A., Ferguson, A. M. N., Ferrando, P., Ferrari, A. G., Ferré-Mateu, A., Ferreira, P. G., Ferreras, I., Ferrero, I., Ferriol, S., Ferruit, P., Filleul, D., Finelli, F., Finkelstein, S. L., Finoguenov, A., Fiorini, B., Flentge, F., Focardi, P., Fonseca, J., Fontana, A., Fontanot, F., Fornari, F., Fosalba, P., Fossati, M., Fotopoulou, S., Fouchez, D., Fourmanoit, N., Frailis, M., Fraix-Burnet, D., Franceschi, E., Franco, A., Franzetti, P., Freihoefer, J., Frenk, C. . S., Frittoli, G., Frugier, P. -A., Frusciante, N., Fumagalli, A., Fumagalli, M., Fumana, M., Fu, Y., Gabarra, L., Galeotta, S., Galluccio, L., Ganga, K., Gao, H., García-Bellido, J., Garcia, K., Gardner, J. P., Garilli, B., Gaspar-Venancio, L. -M., Gasparetto, T., Gautard, V., Gavazzi, R., Gaztanaga, E., Genolet, L., Santos, R. Genova, Gentile, F., George, K., Gerbino, M., Ghaffari, Z., Giacomini, F., Gianotti, F., Gibb, G. P. S., Gillard, W., Gillis, B., Ginolfi, M., Giocoli, C., Girardi, M., Giri, S. K., Goh, L. W. K., Gómez-Alvarez, P., Gonzalez-Perez, V., Gonzalez, A. H., Gonzalez, E. J., Gonzalez, J. C., Beauchamps, S. Gouyou, Gozaliasl, G., Gracia-Carpio, J., Grandis, S., Granett, B. R., Granvik, M., Grazian, A., Gregorio, A., Grenet, C., Grillo, C., Grupp, F., Gruppioni, C., Gruppuso, A., Guerbuez, C., Guerrini, S., Guidi, M., Guillard, P., Gutierrez, C. M., Guttridge, P., Guzzo, L., Gwyn, S., Haapala, J., Haase, J., Haddow, C. R., Hailey, M., Hall, A., Hall, D., Hamaus, N., Haridasu, B. S., Harnois-Déraps, J., Harper, C., Hartley, W. G., Hasinger, G., Hassani, F., Hatch, N. A., Haugan, S. V. H., Häußler, B., Heavens, A., Heisenberg, L., Helmi, A., Helou, G., Hemmati, S., Henares, K., Herent, O., Hernández-Monteagudo, C., Heuberger, T., Hewett, P. C., Heydenreich, S., Hildebrandt, H., Hirschmann, M., Hjorth, J., Hoar, J., Hoekstra, H., Holland, A. D., Holliman, M. S., Holmes, W., Hook, I., Horeau, B., Hormuth, F., Hornstrup, A., Hosseini, S., Hu, D., Hudelot, P., Hudson, M. J., Huertas-Company, M., Huff, E. M., Hughes, A. C. N., Humphrey, A., Hunt, L. K., Huynh, D. D., Ibata, R., Ichikawa, K., Iglesias-Groth, S., Ilbert, O., Ilić, S., Ingoglia, L., Iodice, E., Israel, H., Israelsson, U. E., Izzo, L., Jablonka, P., Jackson, N., Jacobson, J., Jafariyazani, M., Jahnke, K., Jain, B., Jansen, H., Jarvis, M. J., Jasche, J., Jauzac, M., Jeffrey, N., Jhabvala, M., Jimenez-Teja, Y., Muñoz, A. Jimenez, Joachimi, B., Johansson, P. H., Joudaki, S., Jullo, E., Kajava, J. J. E., Kang, Y., Kannawadi, A., Kansal, V., Karagiannis, D., Kärcher, M., Kashlinsky, A., Kazandjian, M. V., Keck, F., Keihänen, E., Kerins, E., Kermiche, S., Khalil, A., Kiessling, A., Kiiveri, K., Kilbinger, M., Kim, J., King, R., Kirkpatrick, C. C., Kitching, T., Kluge, M., Knabenhans, M., Knapen, J. H., Knebe, A., Kneib, J. -P., Kohley, R., Koopmans, L. V. E., Koskinen, H., Koulouridis, E., Kou, R., Kovács, A., Kovačić, I., Kowalczyk, A., Koyama, K., Kraljic, K., Krause, O., Kruk, S., Kubik, B., Kuchner, U., Kuijken, K., Kümmel, M., Kunz, M., Kurki-Suonio, H., Lacasa, F., Lacey, C. G., La Franca, F., Lagarde, N., Lahav, O., Laigle, C., La Marca, A., La Marle, O., Lamine, B., Lam, M. C., Lançon, A., Landt, H., Langer, M., Lapi, A., Larcheveque, C., Larsen, S. S., Lattanzi, M., Laudisio, F., Laugier, D., Laureijs, R., Laurent, V., Lavaux, G., Lawrenson, A., Lazanu, A., Lazeyras, T., Boulc'h, Q. Le, Brun, A. M. C. Le, Brun, V. Le, Leclercq, F., Lee, S., Graet, J. Le, Legrand, L., Leirvik, K. N., Jeune, M. Le, Lembo, M., Mignant, D. Le, Lepinzan, M. D., Lepori, F., Reun, A. Le, Leroy, G., Lesci, G. F., Lesgourgues, J., Leuzzi, L., Levi, M. E., Liaudat, T. I., Libet, G., Liebing, P., Ligori, S., Lilje, P. B., Lin, C. -C., Linde, D., Linder, E., Lindholm, V., Linke, L., Li, S. -S., Liu, S. J., Lloro, I., Lobo, F. S. N., Lodieu, N., Lombardi, M., Lombriser, L., Lonare, P., Longo, G., López-Caniego, M., Lopez, X. Lopez, Alvarez, J. Lorenzo, Loureiro, A., Loveday, J., Lusso, E., Macias-Perez, J., Maciaszek, T., Maggio, G., Magliocchetti, M., Magnard, F., Magnier, E. A., Magro, A., Mahler, G., Mainetti, G., Maino, D., Maiorano, E., Malavasi, N., Mamon, G. A., Mancini, C., Mandelbaum, R., Manera, M., Manjón-García, A., Mannucci, F., Mansutti, O., Outeiro, M. Manteiga, Maoli, R., Maraston, C., Marcin, S., Marcos-Arenal, P., Margalef-Bentabol, B., Marggraf, O., Marinucci, D., Marinucci, M., Markovic, K., Marleau, F. R., Marpaud, J., Martignac, J., Martín-Fleitas, J., Martin-Moruno, P., Martin, E. L., Martinelli, M., Martinet, N., Martin, H., Martins, C. J. A. P., Marulli, F., Massari, D., Massey, R., Masters, D. C., Matarrese, S., Matsuoka, Y., Matthew, S., Maughan, B. J., Mauri, N., Maurin, L., Maurogordato, S., McCarthy, K., McConnachie, A. W., McCracken, H. J., McDonald, I., McEwen, J. D., McPartland, C. J. R., Medinaceli, E., Mehta, V., Mei, S., Melchior, M., Melin, J. -B., Ménard, B., Mendes, J., Mendez-Abreu, J., Meneghetti, M., Mercurio, A., Merlin, E., Metcalf, R. B., Meylan, G., Migliaccio, M., Mignoli, M., Miller, L., Miluzio, M., Milvang-Jensen, B., Mimoso, J. P., Miquel, R., Miyatake, H., Mobasher, B., Mohr, J. J., Monaco, P., Monguió, M., Montoro, A., Mora, A., Dizgah, A. Moradinezhad, Moresco, M., Moretti, C., Morgante, G., Morisset, N., Moriya, T. J., Morris, P. W., Mortlock, D. J., Moscardini, L., Mota, D. F., Mottet, S., Moustakas, L. A., Moutard, T., Müller, T., Munari, E., Murphree, G., Murray, C., Murray, N., Musi, P., Nadathur, S., Nagam, B. C., Nagao, T., Naidoo, K., Nakajima, R., Nally, C., Natoli, P., Navarro-Alsina, A., Girones, D. Navarro, Neissner, C., Nersesian, A., Nesseris, S., Nguyen-Kim, H. N., Nicastro, L., Nichol, R. C., Nielbock, M., Niemi, S. -M., Nieto, S., Nilsson, K., Noller, J., Norberg, P., Nouri-Zonoz, A., Ntelis, P., Nucita, A. A., Nugent, P., Nunes, N. J., Nutma, T., Ocampo, I., Odier, J., Oesch, P. A., Oguri, M., Oliveira, D. Magalhaes, Onoue, M., Oosterbroek, T., Oppizzi, F., Ordenovic, C., Osato, K., Pacaud, F., Pace, F., Padilla, C., Paech, K., Pagano, L., Page, M. J., Palazzi, E., Paltani, S., Pamuk, S., Pandolfi, S., Paoletti, D., Paolillo, M., Papaderos, P., Pardede, K., Parimbelli, G., Parmar, A., Partmann, C., Pasian, F., Passalacqua, F., Paterson, K., Patrizii, L., Pattison, C., Paulino-Afonso, A., Paviot, R., Peacock, J. A., Pearce, F. R., Pedersen, K., Peel, A., Peletier, R. F., Ibanez, M. Pellejero, Pello, R., Penny, M. T., Percival, W. J., Perez-Garrido, A., Perotto, L., Pettorino, V., Pezzotta, A., Pezzuto, S., Philippon, A., Pierre, M., Piersanti, O., Pietroni, M., Piga, L., Pilo, L., Pires, S., Pisani, A., Pizzella, A., Pizzuti, L., Plana, C., Polenta, G., Pollack, J. E., Poncet, M., Pöntinen, M., Pool, P., Popa, L. A., Popa, V., Popp, J., Porciani, C., Porth, L., Potter, D., Poulain, M., Pourtsidou, A., Pozzetti, L., Prandoni, I., Pratt, G. W., Prezelus, S., Prieto, E., Pugno, A., Quai, S., Quilley, L., Racca, G. D., Raccanelli, A., Rácz, G., Radinović, S., Radovich, M., Ragagnin, A., Ragnit, U., Raison, F., Ramos-Chernenko, N., Ranc, C., Rasera, Y., Raylet, N., Rebolo, R., Refregier, A., Reimberg, P., Reiprich, T. H., Renk, F., Renzi, A., Retre, J., Revaz, Y., Reylé, C., Reynolds, L., Rhodes, J., Ricci, F., Ricci, M., Riccio, G., Ricken, S. O., Rissanen, S., Risso, I., Rix, H. -W., Robin, A. C., Rocca-Volmerange, B., Rocci, P. -F., Rodenhuis, M., Rodighiero, G., Monroy, M. Rodriguez, Rollins, R. P., Romanello, M., Roman, J., Romelli, E., Romero-Gomez, M., Roncarelli, M., Rosati, P., Rosset, C., Rossetti, E., Roster, W., Rottgering, H. J. A., Rozas-Fernández, A., Ruane, K., Rubino-Martin, J. A., Rudolph, A., Ruppin, F., Rusholme, B., Sacquegna, S., Sáez-Casares, I., Saga, S., Saglia, R., Sahlén, M., Saifollahi, T., Sakr, Z., Salvalaggio, J., Salvaterra, R., Salvati, L., Salvato, M., Salvignol, J. -C., Sánchez, A. G., Sanchez, E., Sanders, D. B., Sapone, D., Saponara, M., Sarpa, E., Sarron, F., Sartori, S., Sartoris, B., Sassolas, B., Sauniere, L., Sauvage, M., Sawicki, M., Scaramella, R., Scarlata, C., Scharré, L., Schaye, J., Schewtschenko, J. A., Schindler, J. -T., Schinnerer, E., Schirmer, M., Schmidt, F., Schmidt, M., Schneider, A., Schneider, M., Schneider, P., Schöneberg, N., Schrabback, T., Schultheis, M., Schulz, S., Schuster, N., Schwartz, J., Sciotti, D., Scodeggio, M., Scognamiglio, D., Scott, D., Scottez, V., Secroun, A., Sefusatti, E., Seidel, G., Seiffert, M., Sellentin, E., Selwood, M., Semboloni, E., Sereno, M., Serjeant, S., Serrano, S., Setnikar, G., Shankar, F., Sharples, R. M., Short, A., Shulevski, A., Shuntov, M., Sias, M., Sikkema, G., Silvestri, A., Simon, P., Sirignano, C., Sirri, G., Skottfelt, J., Slezak, E., Sluse, D., Smith, G. P., Smith, L. C., Smith, R. E., Smit, S. J. A., Soldano, F., Solheim, B. G. B., Sorce, J. G., Sorrenti, F., Soubrie, E., Spinoglio, L., Mancini, A. Spurio, Stadel, J., Stagnaro, L., Stanco, L., Stanford, S. A., Starck, J. -L., Stassi, P., Steinwagner, J., Stern, D., Stone, C., Strada, P., Strafella, F., Stramaccioni, D., Surace, C., Sureau, F., Suyu, S. H., Swindells, I., Szafraniec, M., Szapudi, I., Taamoli, S., Talia, M., Tallada-Crespí, P., Tanidis, K., Tao, C., Tarrío, P., Tavagnacco, D., Taylor, A. N., Taylor, J. E., Taylor, P. L., Teixeira, E. M., Tenti, M., Idiago, P. Teodoro, Teplitz, H. I., Tereno, I., Tessore, N., Testa, V., Testera, G., Tewes, M., Teyssier, R., Theret, N., Thizy, C., Thomas, P. D., Toba, Y., Toft, S., Toledo-Moreo, R., Tolstoy, E., Tommasi, E., Torbaniuk, O., Torradeflot, F., Tortora, C., Tosi, S., Tosti, S., Trifoglio, M., Troja, A., Trombetti, T., Tronconi, A., Tsedrik, M., Tsyganov, A., Tucci, M., Tutusaus, I., Uhlemann, C., Ulivi, L., Urbano, M., Vacher, L., Vaillon, L., Valageas, P., Valdes, I., Valentijn, E. A., Valenziano, L., Valieri, C., Valiviita, J., Broeck, M. Van den, Vassallo, T., Vavrek, R., Vega-Ferrero, J., Venemans, B., Venhola, A., Ventura, S., Kleijn, G. Verdoes, Vergani, D., Verma, A., Vernizzi, F., Veropalumbo, A., Verza, G., Vescovi, C., Vibert, D., Viel, M., Vielzeuf, P., Viglione, C., Viitanen, A., Villaescusa-Navarro, F., Vinciguerra, S., Visticot, F., Voggel, K., von Wietersheim-Kramsta, M., Vriend, W. J., Wachter, S., Walmsley, M., Walth, G., Walton, D. M., Walton, N. A., Wander, M., Wang, L., Wang, Y., Weaver, J. R., Weller, J., Wetzstein, M., Whalen, D. J., Whittam, I. H., Widmer, A., Wiesmann, M., Wilde, J., Williams, O. R., Winther, H. -A., Wittje, A., Wong, J. H. W., Wright, A. H., Yankelevich, V., Yeung, H. W., Yoon, M., Youles, S., Yung, L. Y. A., Zacchei, A., Zalesky, L., Zamorani, G., Vitorelli, A. Zamorano, Marc, M. Zanoni, Zennaro, M., Zerbi, F. M., Zinchenko, I. A., Zoubian, J., Zucca, E., and Zumalacarregui, M.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance., Comment: Accepted for publication in the A&A special issue`Euclid on Sky'

Published
2024

6. Small Prime $k$th Power Residues and Nonresidues in Arithmetic Progressions

Author

Carella, N. A.

Subjects
Mathematics - General Mathematics, Primary 11A15, Secondary 11L40, 11E25, 11R29
Abstract

Let $p$ be a large odd prime, let $x=(\log p)^{1+\varepsilon}$ and let $q\ll\log\log p$ be an integer, where $\varepsilon>0$ is a small number. This note proves the existence of small prime quadratic residues and prime quadratic nonresidues in the arithmetic progression $a+qm\ll x$, with relatively prime $1\leq a

Published
2024

7. International multicenter validation of AI-driven ultrasound detection of ovarian cancer

Author

Christiansen, Filip, Konuk, Emir, Ganeshan, Adithya Raju, Welch, Robert, Palés Huix, Joana, Czekierdowski, Artur, Leone, Francesco Paolo Giuseppe, Haak, Lucia Anna, Fruscio, Robert, Gaurilcikas, Adrius, Franchi, Dorella, Fischerova, Daniela, Mor, Elisa, Savelli, Luca, Pascual, Maria Àngela, Kudla, Marek Jerzy, Guerriero, Stefano, Buonomo, Francesca, Liuba, Karina, Montik, Nina, Alcázar, Juan Luis, Domali, Ekaterini, Pangilinan, Nelinda Catherine P., Carella, Chiara, Munaretto, Maria, Saskova, Petra, Verri, Debora, Visenzi, Chiara, Herman, Pawel, Smith, Kevin, and Epstein, Elisabeth

Published
2025
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8. Nutritional assessment and medical dietary therapy for management of obesity in patients with non-dialysis chronic kidney disease: a practical guide for endocrinologist, nutritionists and nephrologists. A consensus statement from the Italian society of endocrinology (SIE), working group of the club nutrition–hormones and metabolism; the Italian society of nutraceuticals (SINut), club ketodiets and nutraceuticals “KetoNut-SINut”; and the Italian society of nephrology (SIN)

Author

Annunziata, G., Caprio, M., Verde, L., Carella, A. M., Camajani, E., Benvenuto, A., Paolini, B., De Nicola, L., Aucella, F., Bellizzi, V., Barberi, S., Grassi, D., Fogacci, F., Colao, A., Cicero, A. F. G., Prodam, F., Aimaretti, G., Muscogiuri, G., and Barrea, L.

Published
2024
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10. Legendre Conjecture over Arithmetic Progressions

Author

Carella, N. A.

Subjects
Mathematics - General Mathematics, Primary 11N05, Secondary 11N32
Abstract

Let $1\leq a1$ be a large number. This note discusses the existence of a short sequence of primes $p\equiv a\bmod q$ between two squares $x^2$ and $(x+1)^2$., Comment: Seven Pages. Keywords: Prime in short interval; Prime in arithmetic progression; Distribution of prime; Legendre conjecture

Published
2024

11. Euclid preparation. Modelling spectroscopic clustering on mildly nonlinear scales in beyond-$\Lambda$CDM models

Author

Euclid Collaboration, Bose, B., Carrilho, P., Marinucci, M., Moretti, C., Pietroni, M., Carella, E., Piga, L., Wright, B. S., Vernizzi, F., Carbone, C., Casas, S., D'Amico, G., Frusciante, N., Koyama, K., Pace, F., Pourtsidou, A., Baldi, M., de la Bella, L. F., Fiorini, B., Giocoli, C., Lombriser, L., Aghanim, N., Amara, A., Andreon, S., Auricchio, N., Bardelli, S., Bodendorf, C., Bonino, D., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Capobianco, V., Cardone, V. F., Carretero, J., Castellano, M., Cavuoti, S., Cimatti, A., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Costille, A., Courbin, F., Courtois, H. M., Da Silva, A., Degaudenzi, H., Di Giorgio, A. M., Dubath, F., Duncan, C. A. J., Dupac, X., Dusini, S., Farina, M., Farrens, S., Ferriol, S., Fosalba, P., Frailis, M., Franceschi, E., Galeotta, S., Garilli, B., Gillis, B., Grazian, A., Grupp, F., Guzzo, L., Haugan, S. V. H., Hormuth, F., Hornstrup, A., Jahnke, K., Joachimi, B., Keihänen, E., Kermiche, S., Kiessling, A., Kilbinger, M., Kitching, T., Kunz, M., Kurki-Suonio, H., Ligori, S., Lilje, P. B., Lindholm, V., Lloro, I., Maino, D., Maiorano, E., Mansutti, O., Marggraf, O., Markovic, K., Martinet, N., Marulli, F., Massey, R., Medinaceli, E., Meneghetti, M., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. -M., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Percival, W. J., Pettorino, V., Pires, S., Polenta, G., Poncet, M., Popa, L. A., Pozzetti, L., Raison, F., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Roncarelli, M., Saglia, R., Sapone, D., Sartoris, B., Schneider, P., Secroun, A., Seidel, G., Seiffert, M., Serrano, S., Sirignano, C., Sirri, G., Stanco, L., Starck, J. -L., Tallada-Crespí, P., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valentijn, E. A., Valenziano, L., Vassallo, T., Veropalumbo, A., Wang, Y., Weller, J., Zamorani, G., Zoubian, J., Zucca, E., Biviano, A., Bozzo, E., Burigana, C., Colodro-Conde, C., Di Ferdinando, D., Graciá-Carpio, J., Mauri, N., Neissner, C., Sakr, Z., Scottez, V., Tenti, M., Viel, M., Wiesmann, M., Akrami, Y., Allevato, V., Anselmi, S., Ballardini, M., Bernardeau, F., Borgani, S., Bruton, S., Cabanac, R., Cappi, A., Carvalho, C. S., Castignani, G., Castro, T., Cañas-Herrera, G., Chambers, K. C., Cooray, A. R., Coupon, J., Davini, S., de la Torre, S., De Lucia, G., Desprez, G., Di Domizio, S., Dole, H., Díaz-Sánchez, A., Vigo, J. A. Escartin, Escoffier, S., Ferreira, P. G., Ferrero, I., Finelli, F., Gabarra, L., Ganga, K., García-Bellido, J., Giacomini, F., Gozaliasl, G., Guinet, D., Hall, A., Joudaki, S., Kajava, J. J. E., Kansal, V., Karagiannis, D., Kirkpatrick, C. C., Legrand, L., Loureiro, A., Macias-Perez, J., Magliocchetti, M., Maoli, R., Martinelli, M., Martins, C. J. A. P., Matthew, S., Maturi, M., Maurin, L., Metcalf, R. B., Migliaccio, M., Monaco, P., Morgante, G., Nadathur, S., Walton, Nicholas A., Patrizii, L., Pezzotta, A., Popa, V., Porciani, C., Potter, D., Pöntinen, M., Reimberg, P., Rocci, P. -F., Sánchez, A. G., Schneider, A., Sefusatti, E., Sereno, M., Silvestri, A., Mancini, A. Spurio, Steinwagner, J., Testera, G., Teyssier, R., Toft, S., Tosi, S., Troja, A., Tucci, M., Valiviita, J., and Vergani, D.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We investigate the approximations needed to efficiently predict the large-scale clustering of matter and dark matter halos in beyond-$\Lambda$CDM scenarios. We examine the normal branch of the Dvali-Gabadadze-Porrati model, the Hu-Sawicki $f(R)$ model, a slowly evolving dark energy, an interacting dark energy model and massive neutrinos. For each, we test approximations for the perturbative kernel calculations, including the omission of screening terms and the use of perturbative kernels based on the Einstein-de Sitter universe; we explore different infrared-resummation schemes, tracer bias models and a linear treatment of massive neutrinos; we employ two models for redshift space distortions, the Taruya-Nishimishi-Saito prescription and the Effective Field Theory of Large-Scale Structure. This work further provides a preliminary validation of the codes being considered by Euclid for the spectroscopic clustering probe in beyond-$\Lambda$CDM scenarios. We calculate and compare the $\chi^2$ statistic to assess the different modelling choices. This is done by fitting the spectroscopic clustering predictions to measurements from numerical simulations and perturbation theory-based mock data. We compare the behaviour of this statistic in the beyond-$\Lambda$CDM cases, as a function of the maximum scale included in the fit, to the baseline $\Lambda$CDM case. We find that the Einstein-de Sitter approximation without screening is surprisingly accurate for all cases when comparing to the halo clustering monopole and quadrupole obtained from simulations. Our results suggest that the inclusion of multiple redshift bins, higher-order multipoles, higher-order clustering statistics (such as the bispectrum) and photometric probes such as weak lensing, will be essential to extract information on massive neutrinos, modified gravity and dark energy., Comment: 29 pages, 10 figures, 4 tables, 3 appendices. Journal accepted version

Published
2023
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12. Correction: Inflammation scores based on C‑reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis

Author

Di Rosa, Mirko, Sabbatinelli, Jacopo, Giuliani, Angelica, Carella, Miriam, Magro, Daniele, Biscetti, Leonardo, Soraci, Luca, Spannella, Francesco, Fedecostante, Massimiliano, Lenci, Federica, Tortato, Elena, Pimpini, Lorenzo, Burattini, Maurizio, Cecchini, Sara, Cherubini, Antonio, Bonfigli, Anna Rita, Capalbo, Maria, Procopio, Antonio Domenico, Balistreri, Carmela Rita, and Olivieri, Fabiola

Published
2024
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13. Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis

Author

Di Rosa, Mirko, Sabbatinelli, Jacopo, Giuliani, Angelica, Carella, Miriam, Magro, Daniele, Biscetti, Leonardo, Soraci, Luca, Spannella, Francesco, Fedecostante, Massimiliano, Lenci, Federica, Tortato, Elena, Pimpini, Lorenzo, Burattini, Maurizio, Cecchini, Sara, Cherubini, Antonio, Bonfigli, Anna Rita, Capalbo, Maria, Procopio, Antonio Domenico, Balistreri, Carmela Rita, and Olivieri, Fabiola

Published
2024
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14. Busulfan-fludarabine versus busulfan-cyclophosphamide for allogeneic transplant in acute myeloid leukemia: long term analysis of GITMO AML-R2 trial

Author

Cavallaro, Gianluca, Grassi, Anna, Pavoni, Chiara, Micò, Maria Caterina, Busca, Alessandro, Cavattoni, Irene Maria, Santarone, Stella, Borghero, Carlo, Olivieri, Attilio, Milone, Giuseppe, Chiusolo, Patrizia, Musto, Pellegrino, Saccardi, Riccardo, Patriarca, Francesca, Pane, Fabrizio, Saporiti, Giorgia, Rivela, Paolo, Terruzzi, Elisabetta, Cerretti, Raffaella, Marotta, Giuseppe, Carella, Angelo Michele, Nagler, Arnon, Russo, Domenico, Corradini, Paolo, Bernasconi, Paolo, Iori, Anna Paola, Castagna, Luca, Mordini, Nicola, Oldani, Elena, Di Grazia, Carmen, Bacigalupo, Andrea, and Rambaldi, Alessandro

Published
2024
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15. Stem cell collection and hematological recovery in the Fondazione Italiana Linfomi (FIL) MCL0208 clinical trial

Author

Clerico, Michele, Ferrero, Simone, Alessandria, Beatrice, Zaccaria, Gian Maria, Genuardi, Elisa, Ragaini, Simone, Tavarozzi, Rita, Cavallo, Federica, Hohaus, Stefan, Musuraca, Gerardo, Carella, Angelo Michele, Stelitano, Caterina, Tani, Monica, Gaidano, Gianluca, Olivieri, Jacopo, Usai, Sara Veronica, Galimberti, Sara, Re, Francesca, Mian, Michael, Castellino, Claudia, Pavone, Vincenzo, Evangelista, Andrea, Bruno, Benedetto, Cortelazzo, Sergio, Passera, Roberto, and Ladetto, Marco

Published
2024
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17. Human leukocyte antigen variants associate with BNT162b2 mRNA vaccine response

Author

Esposito, Martina, Minnai, Francesca, Copetti, Massimiliano, Miscio, Giuseppe, Perna, Rita, Piepoli, Ada, De Vincentis, Gabriella, Benvenuto, Mario, D’Addetta, Paola, Croci, Susanna, Baldassarri, Margherita, Bruttini, Mirella, Fallerini, Chiara, Brugnoni, Raffaella, Cavalcante, Paola, Baggi, Fulvio, Corsini, Elena Maria Grazia, Ciusani, Emilio, Andreetta, Francesca, Dragani, Tommaso A., Fratelli, Maddalena, Carella, Massimo, Mantegazza, Renato E., Renieri, Alessandra, and Colombo, Francesca

Published
2024
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18. Inflammation and acute cardiotoxicity in adult hematological patients treated with CAR-T cells: results from a pilot proof-of-concept study

Author

Camilli, Massimiliano, Viscovo, Marcello, Felici, Tamara, Maggio, Luca, Ballacci, Federico, Carella, Giacomo, Bonanni, Alice, Lamendola, Priscilla, Tinti, Lorenzo, Di Renzo, Antonio, Coarelli, Giulia, Galli, Eugenio, Liuzzo, Giovanna, Burzotta, Francesco, Montone, Rocco Antonio, Sorà, Federica, Sica, Simona, Hohaus, Stefan, Lanza, Gaetano Antonio, Crea, Filippo, Lombardo, Antonella, and Minotti, Giorgio

Published
2024
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20. Squarefree Values Of Polynomials

Author

Carella, N. A.

Subjects
Mathematics - General Mathematics, Primary 11N32, Secondary 11N25, 11N37
Abstract

This note presents new results for the squarefree value sets of quartic polynomials over the integers., Comment: Twenty-Eight Pages. Keywords: Squarefree integer, Irreducible polynomial

Published
2023

21. Largest Prime Factors of Polynomials

Author

Carella, N. A.

Subjects
Mathematics - General Mathematics, Primary 11N05, Secondary 11N32
Abstract

LLet $x>1$ be a large number. This note shows that the largest prime factor of the quadratic product $\prod_{x\leq n\leq 2x}\left(n^2+1 \right)$ satisfies the relation $p \geq x^{3/2}$ as $x$ tends to infinity. This improves the current estimate $p \geq x^{1.279}$. In addition, it is shown that $n^2+1 $ has a large prime divisor in the interval $ p\in [x^{2-o(1)},x^2] $ for some $ n\geq x^{1-o(1)}$., Comment: Twenty Eight Pages. Keywords: Prime number; Distribution of prime; Polynomial prime value

Published
2023

22. DEMNUni: cross-correlating the nonlinear ISWRS effect with CMB-lensing and galaxies in the presence of massive neutrinos

Author

Cuozzo, Viviana, Carbone, Carmelita, Calabrese, Matteo, Carella, Elisabetta, and Migliaccio, Marina

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present an analytical modelling of the angular cross-correlations between the Integrated Sachs Wolfe-Rees Sciama (ISWRS) effect and large-scale structure tracers in the presence of massive neutrinos. Our method has been validated against large N-body simulations with a massive neutrino particle component, namely the DEMNUni suite. We investigate the impact of different neutrino masses on the cross-correlations between the ISWRS effect and both the galaxy clustering and the lensing of the Cosmic Microwave Background (CMB). We also test the ability of current nonlinear matter power spectrum modellings to reproduce neutrino effects in such cross-correlations. We show that the multipole position of a characteristic sign inversion in the cross-spectra, due to nonlinear effects, is strongly related to the total neutrino mass $M_\nu$ and depends almost linearly on it. While these nonlinear cross-correlation signals may not be able alone to constrain the neutrino mass, our approach paves the way to the detection of such cross-spectra on small scales for their exploitation in combination with main probes from future galaxy surveys and CMB experiments., Comment: 30 pages, 13 figures (new version of several figures), this version matches the accepted version in JCAP

Published
2023
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23. Note on the Distribution of the Traces of Frobenius

Author

Carella, N. A.

Subjects
Mathematics - General Mathematics, Primary 11K06, 11M50, Secondary 11G20, 14G10. and 14K15
Abstract

Let $E$ be a nonsingular elliptic curve over the rational numbers, and let $\tau^n=p^n+1-\#E(\mathbb{F}_{p^n})$. A result in the current literature claims that the normalized traces of Frobenius $\alpha_n=(\tau^n+\overline{\tau}^n)/2p^{n/2}$ are equidistributed on the interval $[-1,1]$ as $n\to \infty$. This short note has two goals: 1. Proposes a correction to this result on the distribution of the traces of Frobenius. 2. Provides a simple elementary proof of this result. More precisely, it is shown that the sequence $\{\alpha_n:n\geq1\}$ is dense but not equidistributed on the interval $[-1,1]$., Comment: Eleven Pages. Keywords: Algebraic curve; Traces of Frobenius; Sato-Tate distribution

Published
2023

24. Growth Parameters and Prevalence of Obesity in PKU Patients and Peers: Is This the Right Comparison?

Author

Giulia Paterno, Vito Di Tullio, Rosa Carella, Giada De Ruvo, Fabrizio Furioso, Aleksandra Skublewska-D’Elia, Donatella De Giovanni, and Albina Tummolo

Subjects
phenylketonuria, growth, body mass index, overweight, obesity, Medicine, Pediatrics, RJ1-570
Abstract

Background: One of the main objectives of Phenylketonuria (PKU) management is represented by optimising the growth trend under restricted protein diet regimen. The data on long-term growth in PKU children are limited and mostly based on earlier studies. Methods: The data for this twelve-year longitudinal study were collected from 34 PKU children and 37 healthy peers, whose auxological parameters were taken at 7 time-points over the follow-up. The weight-for-length ratio (WLR) z-score and body mass index (BMI) z-score were considered according to age. Prevalence of overweight/obesity was evaluated at last assessment. Results: The median BMI z-score of PKU children was normal and not statistically different from that of controls on all the seven time-point assessments. Their distributions tended to be wider than those of peers, with the upper limit exceeding the normal range since 12 months old, with a peak specifically at 3 years of age. In controls, there was a tendency to approach the BMI z-score values of overweight in later childhood. The prevalence of overweight was comparable (29% vs. 25%, p: 0.78) between the two groups at last assessment, and obese subjects (3/37) were only detected in the control group. Conclusions: In this study, we report data from a long-term follow-up on growth, highlighting that the median BMI z-score of PKU children was normal and not statistically different from that of controls. Also, the prevalence of obesity at 12 years of age was overlapping. However, the high prevalence of overweight children in the general population may explain the lack of difference and does not reassure about patients’ nutritional risk.

Published
2024
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25. Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis

Author

Mirko Di Rosa, Jacopo Sabbatinelli, Angelica Giuliani, Miriam Carella, Daniele Magro, Leonardo Biscetti, Luca Soraci, Francesco Spannella, Massimiliano Fedecostante, Federica Lenci, Elena Tortato, Lorenzo Pimpini, Maurizio Burattini, Sara Cecchini, Antonio Cherubini, Anna Rita Bonfigli, Maria Capalbo, Antonio Domenico Procopio, Carmela Rita Balistreri, and Fabiola Olivieri

Subjects
Older patients, In-hospital mortality, C-reactive protein, CRP-to-albumin ratio, Immunologic diseases. Allergy, RC581-607, Geriatrics, RC952-954.6
Abstract

Abstract Systemic inflammation significantly increases the risk of short- and long-term mortality in geriatric hospitalized patients. To predict mortality in older patients with various age-related diseases and infections, including COVID-19, inflammatory biomarkers such as the C-reactive protein (CRP) to albumin ratio (CAR), and related scores and indexes, i.e. Glasgow Prognostic Score (GPS), modified GPS (mGPS), and high sensitivity (hs)-mGPS, have been increasingly utilized. Despite their easy affordability and widespread availability, these biomarkers are predominantly assessed for clinical purposes rather than predictive applications, leading to their underutilization in hospitalized older patients. In this study, we investigated the association of CAR, GPS, mGPS, and hs-mGPS with short-term mortality in 3,206 geriatric hospitalized patients admitted for acute conditions, irrespective of admission diagnosis. We observed that unit increases of CAR, and the highest classes of GPS, mGPS, and hs-mGPS were significantly associated with a two- to threefold increased risk of death, even adjusting the risk for different confounding variables. Interestingly, a hs-mGPS of 2 showed the highest effect size. Furthermore, gender analysis indicated a stronger association between all CRP-albumin based parameters and mortality in men, underscoring the gender-specific relevance of inflammation-based circulating parameters in mortality prediction. In conclusion, scores based on serum CRP and albumin levels offer additional guidance for the stratification of in-hospital mortality risk in older patients by providing additional information on the degree of systemic inflammation.

Published
2024
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26. Busulfan-fludarabine versus busulfan-cyclophosphamide for allogeneic transplant in acute myeloid leukemia: long term analysis of GITMO AML-R2 trial

Author

Gianluca Cavallaro, Anna Grassi, Chiara Pavoni, Maria Caterina Micò, Alessandro Busca, Irene Maria Cavattoni, Stella Santarone, Carlo Borghero, Attilio Olivieri, Giuseppe Milone, Patrizia Chiusolo, Pellegrino Musto, Riccardo Saccardi, Francesca Patriarca, Fabrizio Pane, Giorgia Saporiti, Paolo Rivela, Elisabetta Terruzzi, Raffaella Cerretti, Giuseppe Marotta, Angelo Michele Carella, Arnon Nagler, Domenico Russo, Paolo Corradini, Paolo Bernasconi, Anna Paola Iori, Luca Castagna, Nicola Mordini, Elena Oldani, Carmen Di Grazia, Andrea Bacigalupo, and Alessandro Rambaldi

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract We report the long-term results of a randomized trial (GITMO, AML-R2), comparing 1:1 the combination of busulfan and cyclophosphamide (BuCy2, n = 125) and the combination of busulfan and fludarabine (BuFlu, n = 127) as conditioning regimen in acute myeloid leukemia patients (median age 51 years, range 40–65) undergoing allogeneic hematopoietic stem cell transplantation. With a median follow-up of 6 years, significantly better non-relapse mortality (NRM) was confirmed in BuFlu recipients, which is sustained up to 4 years after transplant (10% vs. 20%, p = 0.0388). This difference was higher in patients older than 51 years (11% in BuFlu vs. 27% in BuCy2, p = 0.0262). The cumulative incidence of relapse, which was the first cause of death in the entire study population, did not differ between the two randomized arms. Similarly, the leukemia-free survival (LFS) and overall survival (OS) were not different in the two cohorts, even when stratifying patients per median age. Graft-and relapse-free survival (GRFS) in BuFlu arm vs. the BuCy2 arm was 25% vs. 20% at 4 years and 20% vs. 17% at 10 years. Hence, the benefit gained by NRM reduction is not offsets by an increased relapse. Leukemia relapse remains a major concern, urging the development of new therapeutic approaches.

Published
2024
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27. A Result for Germain Primes

Author

Carella, N. A.

Subjects
Mathematics - General Mathematics, Primary 11N05, Secondary 11N32
Abstract

This article determines a lower bound for the number Germain primes $p$ and $2p+1$ up to a large number $x$., Comment: Seventeen Pages. Keywords: Distribution of Primes; Germain Primes Conjecture; dePolignac Conjecture, Artin conjecture

Published
2023

28. Distinct chromosomal mutation associated with cefiderocol resistance in Acinetobacter baumannii: a combined bioinformatics and mass spectrometry approach to unveil and validate the in vivo-acquired chemoresistance

Author

Lavinia Morosi, Davide Golzato, Linda Bussini, Hygerda Guma, Federica Tordato, Federica Armanini, Zian Asif, Francesco Carella, Paola Morelli, Michele Bartoletti, Giorgio Da Rin, Erminia Casari, Giuseppe Martano, Maria Rescigno, Nicola Segata, Sara Carloni, and Valeria Cento

Subjects
Acinetobacter, cefiderocol, CRAB, variant calling analysis, LC–MS/MS, Microbiology, QR1-502
Abstract

Acinetobacter baumannii is a significant public health concern due to the emergence of antibiotic-resistant strains. Cefiderocol (FDC), a novel siderophore cephalosporin, has shown promise as a last-line treatment for multidrug-resistant Gram-negative bacteria. However, the emergence of in vivo-acquired FDC-resistant A. baumannii strains highlights the need for advanced tools to identify resistance-associated genomic mutations and address the challenges of FDC susceptibility testing. This study aims to characterize a novel mutation responsible for FDC resistance in A. baumannii and to develop a workflow that integrates genomic and functional analyses for improved antimicrobial resistance monitoring. We examined two carbapenem-resistant A. baumannii isolates from bacteremia cases in two patients (A. baumannii_5406 from patient A and A. baumannii_5577 from patient B). Initial whole-genome sequence BLAST typing identified both as the same strain. However, a minimum inhibitory concentration (MIC) analysis showed that A. baumannii_5406 was resistant to FDC, while _5577 was not. Further variant calling analysis revealed a novel chromosomal mutation in a gene encoding a TonB-dependent receptor homolog, which is involved in ferric-siderophore and heme uptake. This mutation causes a premature stop codon, likely impairing the receptor’s function. Mass spectrometry confirmed that the FDC-resistant strain exhibited reduced antibiotic uptake and intracellular accumulation. This study demonstrates the utility of combining genomic and functional analyses to detect emerging mutations associated with antibiotic resistance. The variant calling approach, together with LC–MS/MS technology, offers a valuable complement to traditional susceptibility testing in clinical settings, potentially improving the identification and monitoring of FDC resistance in A. baumannii. Additionally, this workflow could aid in the epidemiological tracking of resistant strains.

Published
2024
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29. Role of gastroenterologists and healthcare providers in promoting COVID-19 immunization among individuals with inflammatory bowel disease: A systematic review and meta-analysis on a global scale

Author

Francesco Paolo Bianchi, Maurizio Polignano, Nicola Carella, Ornella Rotolo, Margherita Curlo, and Mauro Mastronardi

Subjects
Crohn’s disease, ulcerative colitis, vaccine hesitancy, SARS-CoV-2, biological drugs, immunosuppressive therapy, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950
Abstract

ABSTRACTIndividuals with Inflammatory Bowel Disease (IBD) are more susceptible to experiencing severe complications of COVID-19 if infected. Nevertheless, sub-optimal immunization rates have been reported among these patients. Our study aims to assess COVID-19 VH among a global population of patients with IBD and to investigate the role of healthcare professionals, particularly gastroenterologists, in promoting immunization. Twenty-six studies were systematically selected from scientific articles in the MEDLINE/PubMed, WoK, and Scopus databases from January 1, 2020, to September 15, 2023. The pooled prevalence of COVID-19 VH was 27.2% (95%CI = 20.6–34.2%). A significant relationship was evidenced between COVID-19 vaccine compliance and receiving advice from gastroenterologists or healthcare providers (OR = 2.77; 95%CI = 1.79–4.30). By leveraging their knowledge of IBD, familiarity with patient histories, and trusted patient-doctor relationships, gastroenterologists are pivotal in promoting vaccination. This patient-centered care is crucial in increasing vaccine acceptance among individuals with IBD, contributing to better public health outcomes.

Published
2024
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30. Equidistributions of Sign Patterns of the Liouville Function and Normal Numbers

Author

Carella, N. A.

Subjects
Mathematics - General Mathematics, Primary 11K16
Abstract

The equidistribution of the double sign patterns of the Liouville function $\lambda$ is proved unconditionally. As application, it is shown that the computable real number $$\sum_{n \geq 1} \frac{1+\lambda(n)}{2^{n}}$$ is a simply normal number in base 4., Comment: Eighteen Pages. Keywords: Sign pattern; Liouille function; Normal number

Published
2022

31. Santander Statement: Towards Global Convergence in Transplantation: Sufficiency, Transparency, and Oversight

Author

Adamec, Milos, Ahn, Curie, Albreht, Katarina, Almén, Helena, Al Obaidli, Ali Abdul Kareem, Anušić Juričić, Martina, Arrabal, Samuel, Ascher, Nancy, Ashkenazi, Tamar, Avendaño-Solá, Cristina, Avsec, Danica, Badenes, Rafael, Bal, Omer, Ballesté, Chloë, Barquero, Teresita, Be, Alicia, Beltrán, Mauricio, Bengochea, Milka, Beqo, Flutra, Berenguer, Marina, Berishvili, Ekaterina, Bokhorst, Arlinke, Boletis, Ioannis, Bolocan, Vladimir, Koh, Mickey BC, Börgel, Martin, Briceño, Javier, Brix-Zuleger, Martina, Busic, Mirela, Buziuviene, Audrone, Caballero, Xavier, Caamaño, Aimée, Carmona, Mar, Capron, Alexander, Cardillo, Massimo, Carella, Claudia, Castillo, María Esther, Cervantes, Lilia, Chandrasekar, Akila, Chaouali, Mafaten, Chatzixiros, Efstratios, Ciccocioppo, Rachele, Cillo, Umberto, Cloherty, Jenny, Colenbie, Luc, Coll, Elisabeth, Cooper, Matthew, Correa-Rocha, Rafael, Cortesi, Paolo Angelo, Cozzi, Emanuele, Cuende, Natividad, Cuero, César, Antonio Da Silva, Juan, Daga, Domingo, Danielyan, Samvel, Danovitch, Gabriel, de Andrade, Joel, de Angelis, Vincenzo, Dedinska, Ivana, del Río, Francisco J., Delmonico, Francis L., Di Ciaccio, Paola, Doerr, Petra, Domínguez-Gil, Beatriz, Emery, Marie-Pierre, Espinel, Mauricio, Fadhil, Riadh, Foeken, Lydia, Forsberg, Anna, Forsythe, John L. R., Friend, Peter, Gadžijev, Andrej, Gallego, Daniel, Gardiner, Dale, Gatt, Sandra, Gjerek, Jernej, Gondolesi, Gabriel, Haraldsson, Börje, Hasal, Antonín, Hennerbichler, Simone, Hernández-Maraver, Dolores, Herson, Marisa, Hickey, Laura, Humar, Simona, Ilbawi, Andre, Immer, Franz, Izeta, Ander, Hawthorne, Wayne J., Jha, Vivekanand, Joyce, Ruth, Jusinskis, Janis, Kaminski, Artur, Kazancıoğlu, Rümeyza, Kim, Joe, Lentine, Krista L., Fraga, Marta López, Lundin, Kersti, Mahillo, Beatriz, Maier, Philip, Mallet, Laurent, Manas, Derek, Manyalich, Marti, Marco, Jaime, Martin, Dominique E., Martínez-Donate, María Dolores, Martjak, Marge, McGee, Andrew, McPhaden, Marcelle, Menjívar, Ana, Mey, Devi, Mihály, Sándor, Mihelčič, Petra, Miñambres, Eduardo, Mirabet, Sonia, Mojsova Mijovska, Maja, Montrasio, Lorenzo, María Moraleda, Jose, Morales, Fernando, Mueller, Thomas, Muller, Elmi, Musquera, Mireia, Nagral, Sanjay, Nathan, Naomi, Nikolac, Vanja, Niño Murcia, Alejandro, Noel, Luc, O’Sullivan, Siobhan, Oniscu, Gabriel C., Opdam, Helen, Orlando, Giuseppe, Ortega, Noelia, Padilla, Benita, Papatheodoridis, George, Pérez Bech, Eva, Pérez Blanco, Alicia, Pérez Martínez, Antonio, Perojo, Dolores, Pires Silva, Ana, Plattner, Verena, Porte, Robert, Potashnik, Anna, Potena, Luciano, Gilberto Prasca, Tomás, Premužić, Marina, Procaccio, Francesco, Rahmel, Axel, Randazzo, Enrico, Raptis, Dimitri A, Rela, Mohamed, Resanović, Vladimir, Rizzolo, Katherine, Adina Rugescu, Iona, Ruiz-Pérez, Blanca, Sainte-Marie, Isabelle, Angelica Salinas, Maria, Sánchez Ibáñez, Jacinto, Serrano, Roselyn, Shaheen, Faissal A., Shemie, Sam, Snyder, Jon, Marie Sørensen, Ragnhild, Spiro, Michael, Stock, Peter, Subotić-Popović, Andreja, Gracious, Noble, Sureda, Ana, Tassot, Johanna, ten Ham, Renske, Thomson, David, Timbalari, Tatiana, Torres, Martín, Tort, Jaume, Trias, Esteve, Trojan, Diletta, Tsimaratos, Mitchel, Tullius, Stefan G., Van Assche, Kristof, Van der Spiegel, Stefaan, Vatachki, Guenadiy, Velasco, Belén, Villatoro, Matías, Walsh, John, Wang, Haibo, and Waterman, Amy

Published
2025
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34. Stem cell collection and hematological recovery in the Fondazione Italiana Linfomi (FIL) MCL0208 clinical trial

Author

Michele Clerico, Simone Ferrero, Beatrice Alessandria, Gian Maria Zaccaria, Elisa Genuardi, Simone Ragaini, Rita Tavarozzi, Federica Cavallo, Stefan Hohaus, Gerardo Musuraca, Angelo Michele Carella, Caterina Stelitano, Monica Tani, Gianluca Gaidano, Jacopo Olivieri, Sara Veronica Usai, Sara Galimberti, Francesca Re, Michael Mian, Claudia Castellino, Vincenzo Pavone, Andrea Evangelista, Benedetto Bruno, Sergio Cortelazzo, Roberto Passera, and Marco Ladetto

Subjects
Mantle cell lymphoma (MCL), Autologous stem cell transplantation (ASCT), Peripheral blood stem cells (PBSC), Leukapheresis (LK), Hematological recovery, Medicine, Science
Abstract

Abstract In the frontline high-dose phase 3 FIL-MCL0208 trial (NCT02354313), 8% of enrolled mantle cell lymphoma (MCL) patients could not be randomised to receive lenalidomide (LEN) maintenance vs observation after autologous stem cell transplantation (ASCT) due to inadequate hematological recovery and 52% of those who started LEN, needed a dose reduction due to toxicity. We therefore focused on the role played by CD34 + hematopoietic stem cells (PBSC) harvesting and reinfusion on toxicity and outcome. Overall, 90% (n = 245) of enrolled patients who underwent the first leukapheresis collected ≥ 4 × 106 PBSC/kg, 2.6% (n = 7) mobilized 10 days) was associated with a worse outcome, both in terms of PFS and OS. In conclusion, although the harvesting procedures proved feasible for younger MCL patients, long-lasting cytopenia following ASCT remains a significant issue: this can hinder the administration of effective maintenance therapies, potentially increasing the relapse rate and negatively affecting survival outcomes.

Published
2024
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35. Note on the Chowla Conjecture and the Discrete Fourier Transform

Author

Carella, N. A.

Subjects
Mathematics - General Mathematics, Primary 11N37, Secondary 11L03, 11K31
Abstract

Let $x\geq 1$ be a large integer, and let $a_00$ is an arbitrary constant., Comment: Thirty Four Pages. Keywords: Arithmetic function; Mobius function; Liouville function; Autocorrelation function; Correlation function; Chowla conjecture; Discrete Fourier transform

Published
2022

36. Correction: Inflammation scores based on C‑reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis

Author

Mirko Di Rosa, Jacopo Sabbatinelli, Angelica Giuliani, Miriam Carella, Daniele Magro, Leonardo Biscetti, Luca Soraci, Francesco Spannella, Massimiliano Fedecostante, Federica Lenci, Elena Tortato, Lorenzo Pimpini, Maurizio Burattini, Sara Cecchini, Antonio Cherubini, Anna Rita Bonfigli, Maria Capalbo, Antonio Domenico Procopio, Carmela Rita Balistreri, and Fabiola Olivieri

Subjects
Immunologic diseases. Allergy, RC581-607, Geriatrics, RC952-954.6
Published
2024
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37. An Innovative ICT Platform Targeting Primary Prevention of Gambling Disorder

Author

Cometa, Rita, Cavallo, Giuseppe, Ariano, Vincenza, Carella, Roberto, Pierri, Katia, Lovell, Nigel H., Advisory Editor, Oneto, Luca, Advisory Editor, Piotto, Stefano, Advisory Editor, Rossi, Federico, Advisory Editor, Samsonovich, Alexei V., Advisory Editor, Babiloni, Fabio, Advisory Editor, Liwo, Adam, Advisory Editor, Magjarevic, Ratko, Advisory Editor, Bochicchio, Mario, editor, Siciliano, Pietro, editor, Monteriù, Andrea, editor, Bettelli, Alice, editor, and De Fano, Domenico, editor

Published
2024
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39. How to Use Strategic Design Process to Address Complex Challenges : A Practical Case of Application to Discuss Strategic Design Process’ Fundamental Traits

Author

Carella, Gianluca, Melazzini, Michele, Zurlo, Francesco, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Zanella, Francesca, editor, Bosoni, Giampiero, editor, Di Stefano, Elisabetta, editor, Iannilli, Gioia Laura, editor, Matteucci, Giovanni, editor, Messori, Rita, editor, and Trocchianesi, Raffaella, editor

Published
2024
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40. Designing Employee Experience to Experiment with Novel Working Modes. Action Research Project to Support Organizations in Engaging Employees in a Post-pandemic Scenario

Author

Melazzini, Michele, Carella, Gianluca, Tosi, Francesca, Editor-in-Chief, Germak, Claudio, Series Editor, Zurlo, Francesco, Series Editor, Jinyi, Zhi, Series Editor, Pozzatti Amadori, Marilaine, Series Editor, Caon, Maurizio, Series Editor, Zanella, Francesca, editor, Bosoni, Giampiero, editor, Di Stefano, Elisabetta, editor, Iannilli, Gioia Laura, editor, Matteucci, Giovanni, editor, Messori, Rita, editor, and Trocchianesi, Raffaella, editor

Published
2024
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44. VAL-1221 for the treatment of patients with Lafora disease: study protocol for a single-arm, open-label clinical trial

Author

Paolo Prontera, Orazio Palumbo, Massimo Carella, Corrado Zenesini, Giuseppe Damante, Laura Licchetta, Francesca Bisulli, Lorenzo Muccioli, Luca Vignatelli, Roberto Michelucci, Giuseppe D’Orsi, Elena Pasini, Maria Tappatà, Cinzia Costa, Raffaele Lodi, Serena Mazzone, Dustin Armstrong, Cosimo Altomare, Lidia Di Vito, Nicola Gambacorta, Paola Imbrici, Valentina Imperatore, Antonella Liantonio, and Paola Mantuano

Subjects
Medicine
Abstract

Introduction Lafora disease (LD) is an ultrarare fatal progressive myoclonic epilepsy, causing drug-resistant epilepsy, myoclonus and psychomotor deterioration. LD is caused by mutations in EPM2A or NHLRC1, which lead to the accumulation of polyglucosans in the brain and neurodegeneration. There are no approved treatments for LD. VAL-1221 is a fusion protein comprising the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase, and has demonstrated an ability to clear polyglucosans. We hypothesise that intravenous infusion of VAL-1221 might be able to degrade cerebral polyglucosans and stabilise or improve disease outcomes. The aim of this study is to assess the safety and preliminary efficacy of VAL-1221 in patients with LD.Methods and analysis The study is a phase 2, single-arm, open-label, baseline-controlled clinical trial which will be conducted in a single investigational study centre in Italy, namely the sponsor ‘IRCCS Istituto delle Scienze Neurologiche di Bologna—Azienda USL di Bologna’. The study will enrol six genetically confirmed patients with mid- to late-stage LD. The global duration of the study for each participant will be 18 months, including screening period, open-label treatment (12 months) and follow-up period. VAL-1221 20 mg/kg will be administered as an intravenous infusion every week for 3 weeks, then every other week. Patients will undergo full clinical assessments at baseline, at an intermediate and at the end-of-treatment visit. The primary objective is to evaluate the safety. The exploratory efficacy endpoints will be related to epilepsy, neuropsychological and motor functions, global assessment and disease burden, in addition to biomarkers. Statistical analyses will be primarily descriptive.Ethics and dissemination The study protocol was approved by the local ethics committee (number 232-2023-FARM-AUSLBO-23020, 22 March 2023). The results of this study will be disseminated by the investigators through presentations at international scientific conferences and reported in peer-reviewed scientific journals.Trial registration number European Union Clinical Trials Register (EudraCT 2023-000185-34).

Published
2024
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45. Thrombin generation assay in COVID-19 patients shows a hypocoagulable pattern

Author

Giovanni L. Tiscia, Donatella Colaizzo, Antonio De Laurenzo, Filomena Cappucci, Lucia Fischetti, Elena Chinni, Mario Mastroianno, Giovanni Favuzzi, Massimo Carella, and Elvira Grandone

Subjects
COVID-19, coagulation, thrombin generation assay, coagulopathy, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Patients with COVID-19 often exhibit coagulopathy, which can significantly impact prognosis. Therefore, investigating coagulation in this context is clinically relevant. The thrombin generation assay (TGA) provides comprehensive data on individual clotting patterns. In our study, we utilized a calibrated automated thrombogram to globally assess coagulation in COVID-19 patients. The study included 67 COVID-19 patients (40 hospitalized in the medical ward and 27 in intensive care units) and 45 blood donors for comparison. Our analysis revealed significant differences in TGA parameters (lag time, time-to-peak, thrombin peak, and endogenous thrombin potential) between patients and blood donors, suggesting a hypocoagulable state in the former. Specifically, COVID-19 patients exhibited prolonged lag time and time-to-peak values, as well as lower thrombin peak and endogenous thrombin potential compared to blood donors (Mann-Whitney test: p

Published
2024
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46. Corrigendum: The molecular tumor board as a step in cancer patient management: a southern Italian experience

Author

Stefania Tommasi, Leonarda Maurmo, Alessandro Rizzo, Claudia Carella, Girolamo Ranieri, Simona De Summa, Francesco Mannavola, Vincenzo Emanuele Chiurì, Michele Guida, Claudia Nisi, Michele Montrone, Francesco Giotta, Margherita Patruno, Rosanna Lacalamita, Brunella Pilato, Francesco Alfredo Zito, Livia Fucci, Claudio Antonio Coppola, Paolo Ditonno, Patrizia Nardulli, Davide Quaresmini, and Sabino Strippoli

Subjects
Molecular Tumor Board, precision medicine, comprehensive genomic profile, team, liquid biopsy, Medicine (General), R5-920
Published
2024
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47. Tailored exercise with telehealth monitoring improves adherence and global health in kidney transplant recipients

Author

Marco Vecchiato, Federica Duregon, Emanuele Zanardo, Veronica Baioccato, Giulia Quinto, Alberto Livio, Barbara Mazzucato, Chiara Sarri, Lia Bellis, Claudia Carella, Massimo Cardillo, Daniel Neunhaeuserer, Andrea Ermolao, and Francesca Battista

Subjects
KTR, exercise, physical activity, transplantation, telemedicine, device, Sports, GV557-1198.995
Abstract

IntroductionTailored exercise prescription is a crucial intervention for kidney transplant recipients (KTRs). This longitudinal study investigates the impact on long-term effectiveness of exercise prescriptions over one year follow-up, implementing telehealth tools for exercise administration and adherence monitoring.Materials and methodsKTRs were evaluated with clinical assessments including body composition, blood and urinary parameters, physical performance and quality of life at baseline (T0), after six (T6) and twelve (T12) months. The adherence to prescribed exercise training was monitored via video call interviews until T6 when the sample was divided into a group monitored via wearables (WG) and a group continuing video calls (VG) until T12.ResultsTwenty-six KTRs completed the study. No changes in body composition and kidney function were reported. KTRs showed an improvement in lipid profile, systolic blood pressure, cardiorespiratory fitness and quality of life. WG showed no clinical differences compared to VG except for reported higher quality of life.DiscussionA good adherence to the exercise prescription was obtained with both monitoring methods (232 vs 253 min/week). This study reinforces the inclusion exercise training for KTRs to enhance physical fitness and reduce cardiovascular risk factors. These results emphasize the role of telehealth monitoring methods as motivators for adherence to long-term exercise prescriptions.

Published
2024
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48. The molecular tumor board as a step in cancer patient management: a southern Italian experience

Author

Stefania Tommasi, Leonarda Maurmo, Alessandro Rizzo, Claudia Carella, Girolamo Ranieri, Simona De Summa, Francesco Mannavola, Vincenzo Emanuele Chiurì, Michele Guida, Claudia Nisi, Michele Montrone, Francesco Giotta, Margherita Patruno, Rosanna Lacalamita, Brunella Pilato, Francesco Alfredo Zito, Livia Fucci, Claudio Antonio Coppola, Paolo Ditonno, Patrizia Nardulli, Davide Quaresmini, and Sabino Strippoli

Subjects
Molecular Tumor Board, precision medicine, comprehensive genomic profile, team, liquid biopsy, Medicine (General), R5-920
Abstract

IntroductionThe management of cancer patients follows a Diagnostic Therapeutic and Care Pathway (PDTA) approach, aimed at achieving the optimal balance between care and quality of life. To support this process, precision medicine and innovative technologies [e.g., next-generation sequencing (NGS)] allow rapid identification of genetic-molecular alterations useful for the design of PDTA-approved therapies. If the standard approach proves inadequate, the Molecular Tumor Board (MTB), a group comprising specialists from diverse disciplines, can step in to evaluate a broader molecular profile, proposing potential therapies beyond evidence levels I–II or considering enrolment in clinical trials. Our aim is to analyze the role of the MTB in the entire management of patients in our institute and its impact on the strategy of personalized medicine, particularly when all approved treatments have failed.Materials and methodsIn alignment with European and national guidelines, a panel of clinicians and preclinical specialists from our institution was defined as the MTB core team. We designed and approved a procedure for the operation of this multidisciplinary group, which is the only one operating in the Puglia region.Results and discussionIn 29 months (2021–2023), we discussed and analyzed 93 patients. A total of 44% presented pathogenic alterations, of which 40.4% were potentially actionable. Only 11 patients were proposed for enrollment in clinical trials, treatment with off-label drugs, or AIFA (the Italian pharmaceutical agency for drugs)—5% funding. Our process indicators, time to analysis, and number of patient cases discussed are in line with the median data of other European institutions. Such findings underscore both the importance and usefulness of the integration of an MTB process into the care of oncology patients.

Published
2024
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49. Combining proximal and remote sensing to assess ‘Calatina’ olive water status

Author

Alessandro Carella, Roberto Massenti, Francesco Paolo Marra, Pietro Catania, Eliseo Roma, and Riccardo Lo Bianco

Subjects
precision irrigation, drought stress, Olea europaea L., crop water stress index, normalized difference vegetation index, stem water potential, Plant culture, SB1-1110
Abstract

Developing an efficient and sustainable precision irrigation strategy is crucial in contemporary agriculture. This study aimed to combine proximal and remote sensing techniques to show the benefits of using both monitoring methods, simultaneously assessing the water status and response of ‘Calatina’ olive under two distinct irrigation levels: full irrigation (FI), and drought stress (DS, -3 to -4 MPa). Stem water potential (Ψstem) and stomatal conductance (gs) were monitored weekly as reference indicators of plant water status. Crop water stress index (CWSI) and stomatal conductance index (Ig) were calculated through ground-based infrared thermography. Fruit gauges were used to monitor continuously fruit growth and data were converted in fruit daily weight fluctuations (ΔW) and relative growth rate (RGR). Normalized difference vegetation index (NDVI), normalized difference RedEdge index (NDRE), green normalized difference vegetation index (GNDVI), chlorophyll vegetation index (CVI), modified soil-adjusted vegetation index (MSAVI), water index (WI), normalized difference greenness index (NDGI) and green index (GI) were calculated from data collected by UAV-mounted multispectral camera. Data obtained from proximal sensing were correlated with both Ψstem and gs, while remote sensing data were correlated only with Ψstem. Regression analysis showed that both CWSI and Ig proved to be reliable indicators of Ψstem and gs. Of the two fruit growth parameters, ΔW exhibited a stronger relationship, primarily with Ψstem. Finally, NDVI, GNDVI, WI and NDRE emerged as the vegetation indices that correlated most strongly with Ψstem, achieving high R2 values. Combining proximal and remote sensing indices suggested two valid approaches: a more simplified one involving the use of CWSI and either NDVI or WI, and a more comprehensive one involving CWSI and ΔW as proximal indices, along with WI as a multispectral index. Further studies on combining proximal and remote sensing data will be necessary in order to find strategic combinations of sensors and establish intervention thresholds.

Published
2024
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50. A rare case of solitary plasmacytoma mimicking submucosal lesion of ascending colon: a case report and literature review

Author

Alessandra Carella, Francesco Spannella, Sonia Morè, Riccardo Grifoni, Carlo Romano Settanni, Alessandra Mandolesi, Alessandra Filosa, Gaia Goteri, Gianfranco Boccoli, and Giammarco Fava

Subjects
plasmacytoma, gastrointestinal tumors, submucosal lesion, colonoscopy, digestive endoscopy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Solitary primary extraosseous plasmacytoma is a rare disease in the gastrointestinal tract, recently classified as an “exceptional” tumor of the colon site. The real incidence (one case/population/year) is unknown but reasonably less than 1/10,000,000 cases/year with very few descriptions in the literature. The rare cases described in the literature are often diagnosed after surgery for perforation and with predominant localization of the left colon. The main endoscopic presentation mimics colon carcinoma with ulcerated mass and obstructing lumen. In this paper, we report a rare case of isolated mass mimicking a submucosal lesion of the ascending colon diagnosed in an older female patient by colonoscopy. The patient was almost asymptomatic; she reported only a history of hematochezia without anemia. This mass was successfully treated by surgery and followed by hematological investigations, including bone marrow biopsy, specific laboratory tests, and CT/PET scan, which confirmed primary isolated plasmacytoma of the colon.

Published
2024
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