1. Clinical management outcomes of childhood glaucoma suspects
- Author
-
Kara M. Cavuoto, Carla Jeannette Osigian, Ta C. Chang, and Matthew B. Greenberg
- Subjects
Male ,Intraocular pressure ,Time Factors ,Eye Diseases ,genetic structures ,Economics ,Ocular hypertension ,Glaucoma ,Social Sciences ,lcsh:Medicine ,Blood Pressure ,Vascular Medicine ,Pediatrics ,Cornea ,0302 clinical medicine ,Medicine and Health Sciences ,Family history ,Child ,lcsh:Science ,Multidisciplinary ,Treatment Outcome ,Biometrics ,Child, Preschool ,Hypertension ,Female ,Anatomy ,Network Analysis ,Research Article ,medicine.medical_specialty ,Computer and Information Sciences ,Ocular Anatomy ,Research and Analysis Methods ,Childhood glaucoma ,03 medical and health sciences ,Ocular System ,Claims data ,Ophthalmology ,Computational Techniques ,medicine ,Humans ,Medical history ,Intraocular Pressure ,business.industry ,Significant difference ,lcsh:R ,Biology and Life Sciences ,Infant ,medicine.disease ,eye diseases ,030221 ophthalmology & optometry ,Ocular Hypertension ,lcsh:Q ,sense organs ,business ,030217 neurology & neurosurgery ,Finance ,Follow-Up Studies - Abstract
Purpose To investigate the outcomes of childhood glaucoma suspects. Design Retrospective case series. Methods Records of childhood glaucoma suspects were identified using financial claims data; medical history, baseline biometric and exam findings were recorded. Conversion from suspect to glaucoma was determined based on the Childhood Glaucoma Research Network criteria. The study adheres to the tenets of the Declarations of Helsinki. Results 214 subjects were enrolled, with median age at initial presentation of 6.37 years (interquartertile range: Q1 = 2.46, Q3 = 8.90). 22 (10.2%) subjects developed glaucoma, 64 (29.9%) had ocular hypertension but no glaucoma, 9 (4.2%) had high-risk condition or syndrome without either ocular hypertension or glaucoma after a mean follow up of 39 +/- 34 months. Neither a family history of glaucoma nor patient gender was significantly different between the groups. 40.2% of subjects (86 of 214) had two or more episodes of intraocular pressure (IOP) > 21 mmHg, among which 25.6% (22 of 86) developed glaucoma after a mean duration of 32.8 +/- 33.5 months. Conclusions Up to 25% of children with 2 or more episodes of elevated IOP may develop glaucoma. In 50% of suspects who converted to glaucoma, elevated IOP was not present at the initial evaluation. There is no significant difference in gender, family history, or baseline central corneal thickness between suspects who developed glaucoma compared to the rest. While suspects who converted to glaucoma had higher average, maximum and minimum IOP measurements, there is no clear cutoff between the groups.
- Published
- 2017