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1. Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy

Author: Edwin Wong, Carla Nester, Teresa Cavero, Alexandre Karras, Moglie Le Quintrec, Liz Lightstone, Ute Eisenberger, Maria Jose Soler, David Kavanagh, Erica Daina, Manuel Praga, Nicholas R. Medjeral-Thomas, Anja Gäckler, Clara Garcia-Carro, Andrea Biondani, Frederique Chaperon, Kenneth Kulmatycki, Julie Milojevic, Nicholas J.A. Webb, Prasanna Kumar Nidamarthy, Guido Junge, and Giuseppe Remuzzi
Subjects: complement 3 glomerulopathy, inflammatory kidney disease, iptacopan, kidney transplant, urine protein-to-creatinine ratio, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Introduction: Complement 3 glomerulopathy (C3G) is a rare inflammatory kidney disease mediated by dysregulation of the alternative complement pathway. No targeted therapy exists for this aggressive glomerulonephritis. Efficacy, safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) (measured by complement biomarkers) of iptacopan were assessed in patients with C3G. Methods: In this phase 2, multicenter, open-label, single-arm, nonrandomized study, adults with biopsy-proven, native kidney C3G (native cohort) and kidney transplant recipients with C3G recurrence (recurrent kidney transplant [KT] cohort) received iptacopan twice daily (bid) for 84 days (days 1–21: 10–100 mg; days 22–84: 200 mg). The primary end point was the urine protein-to-creatinine ratio (UPCR; native cohort) and the change in the C3 deposit score of kidney biopsy (recurrent KT cohort). The complement pathway measures included Wieslab assay, soluble C5b9, and serum C3 levels. Results: A total of 27 patients (16 native cohort and 11 recurrent KT cohort) were enrolled and all completed the study. In the native cohort, UPCR levels decreased by 45% from baseline to week 12 (P = 0.0003). In the recurrent KT cohort, the median C3 deposit score decreased by 2.50 (scale: 0–12) on day 84 versus baseline (P = 0.03). Serum C3 levels were normalized in most patients; complement hyperactivity observed pretreatment was reduced. Severe adverse events (AEs) included post-biopsy hematuria and hyperkalemia. No deaths occurred during the study. Conclusion: Iptacopan resulted in statistically significant and clinically important reductions in UPCR and normalization of serum C3 levels in the native cohort and reduced C3 deposit scores in the recurrent KT cohort with favorable safety and tolerability. (ClinicalTrials.gov identifier: NCT03832114).
Published: 2023
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2. Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study

Author: Shannon L. Murphy, John D. Mahan, Jonathan P. Troost, Tarak Srivastava, Amy J. Kogon, Yi Cai, T. Keefe Davis, Hilda Fernandez, Alessia Fornoni, Rasheed A. Gbadegesin, Emily Herreshoff, Pietro A. Canetta, Patrick H. Nachman, Bryce B. Reeve, David T. Selewski, Christine B. Sethna, Chia-shi Wang, Sharon M. Bartosh, Debbie S. Gipson, Katherine R. Tuttle, Ali Gharavi, Wooin Ahn, Gerald B. Appel, Rupali S. Avasare, Revekka Babayev, Ibrahim Batal, Andrew S. Bomback, Eric Brown, Eric S. Campenot, Pietro Canetta, Brenda Chan, Vivette D. D’Agati, Bartosz Foroncewicz, Gian Marco Ghiggeri, William H. Hines, Namrata G. Jain, Krzysztof Kiryluk, Fangming Lin, Francesca Lugani, Maddalena Marasa, Glen Markowitz, Sumit Mohan, Krzysztof Mucha, Thomas L. Nickolas, Jai Radhakrishnan, Maya K. Rao, Renu Regunathan-Shenk, Simone Sanna-Cherchi, Dominick Santoriello, Michael B. Stokes, Natalie Yu, Anthony M. Valeri, Ronald Zviti, Larry A. Greenbaum, William E. Smoyer, Amira Al-Uzri, Isa Ashoor, Diego Aviles, Rossana Baracco, John Barcia, Sharon Bartosh, Craig Belsha, Michael C. Braun, Aftab Chishti, Donna Claes, Carl Cramer, Keefe Davis, Elif Erkan, Daniel Feig, Michael Freundlich, Melisha Hanna, Guillermo Hidalgo, Amrish Jain, Myda Khalid, Mahmoud Kallash, MD, Jerome C. Lane, John Mahan, Nisha Mathews, Carla Nester, Cynthia Pan, Hiren Patel, Adelaide Revell, Rajasree Sreedharan, Julia Steinke, Scott E. Wenderfer, Craig S. Wong, Ronald Falk, William Cook, Vimal Derebail, Agnes Fogo, Adil Gasim, Todd Gehr, Raymond Harris, Jason Kidd, Louis-Philippe Laurin, Will Pendergraft, Vincent Pichette, Thomas Brian Powell, Matthew B. Renfrow, Virginie Royal, Lawrence B. Holzman, Sharon Adler, Charles Alpers, Raed Bou Matar, Elizabeth Brown, Michael Choi, Katherine M. Dell, Ram Dukkipati, Fernando C. Fervenza, Crystal Gadegbeku, Patrick Gipson, Leah Hasely, Sangeeta Hingorani, Michelle A. Hladunewich, Jonathan Hogan, J. Ashley Jefferson, Kenar Jhaveri, Duncan B. Johnstone, Frederick Kaskel, Amy Kogan, Jeffrey Kopp, Kevin V. Lemley, Laura Malaga- Dieguez, Kevin Meyers, Alicia Neu, Michelle Marie O'Shaughnessy, John F. O’Toole, Rulan Parekh, Heather Reich, Kimberly Reidy, Helbert Rondon, Kamalanathan K. Sambandam, John R. Sedor, Jeffrey Schelling, John C. Sperati, Agnes Swiatecka-Urban, Howard Trachtman, Joseph Weisstuch, Olga Zhdanova, Brenda Gillespie, Matthias Kretzler, Bruce M. Robinson, Laura Mariani, Matthew Wladkowski, and Lisa M. Guay-Woodford
Subjects: edema, health-related quality of life, patient-reported outcomes, primary glomerular disease, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Introduction: Prior cross-sectional studies suggest that health-related quality of life (HRQOL) worsens with more severe glomerular disease. This longitudinal analysis was conducted to assess changes in HRQOL with changing disease status. Methods: Cure Glomerulonephropathy (CureGN) is a cohort of patients with minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, IgA vasculitis, or IgA nephropathy. HRQOL was assessed at enrollment and follow-up visits 1 to 3 times annually for up to 5 years with the Patient-Reported Outcomes Measurement Information System (PROMIS). Global health, anxiety, and fatigue domains were measured in all; mobility was measured in children; and sleep-related impairment was measured in adults. Linear mixed effects models were used to evaluate HRQOL responsiveness to changes in disease status. Results: A total of 469 children and 1146 adults with PROMIS scores were included in the analysis. HRQOL improved over time in nearly all domains, though group-level changes were modest. Edema was most consistently associated with worse HRQOL across domains among children and adults. A greater number of symptoms also predicted worse HRQOL in all domains. Sex, age, obesity, and serum albumin were associated with some HRQOL domains. The estimated glomerular filtration rate (eGFR) was only associated with fatigue and adult physical health; proteinuria was not associated with any HRQOL domain in adjusted models. Conclusion: HRQOL measures were responsive to changes in disease activity, as indicated by edema. HRQOL over time was not predicted by laboratory-based markers of disease. Patient-reported edema and number of symptoms were the strongest predictors of HRQOL, highlighting the importance of the patient experience in glomerular disease. HRQOL outcomes inform understanding of the patient experience for children and adults with glomerular diseases.
Published: 2020
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3. Dynein-Mediated Trafficking: A New Mechanism of Diabetic Podocytopathy

Author: Hua Sun, Jillian Weidner, Chantal Allamargot, Robert C. Piper, Jason Misurac, and Carla Nester
Subjects: General Medicine
Published: 2022
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4. Baseline Clinical Characteristics and Complement Biomarkers of Patients with C3 Glomerulopathy Enrolled in Two Phase 2 Studies Investigating the Factor D Inhibitor Danicopan

Author: Steven D. Podos, Howard Trachtman, Gerald B. Appel, Andrew S. Bomback, Bradley P. Dixon, Jack F.M. Wetzels, H. Terence Cook, Samir V. Parikh, Matthew C. Pickering, James Tumlin, Craig B. Langman, Liz Lightstone, C. John Sperati, Erica Daina, Koenraad Peter Bouman, Kara Rice, Jane A. Thanassi, Mingjun Huang, Carla Nester, and Giuseppe Remuzzi
Subjects: Nephrology
Abstract: Introduction: C3 glomerulopathy (C3G) is a rare, progressive kidney disease resulting from dysregulation of the alternative pathway (AP) of complement. Biomarkers at baseline were investigated in patients with C3G who participated in two phase 2 studies with the factor D (FD) inhibitor, danicopan. Methods: Patients with biopsy-confirmed C3G, proteinuria ≥500 mg/day, and estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2 were enrolled into two studies (NCT03369236 and NCT03459443). Biomarker analysis was performed for patients with C3G confirmed by central pathology laboratory re-evaluation. Complement and clinical biomarkers, biopsy composite score, and activity and chronicity indices were assessed at baseline and analyzed by pairwise Spearman correlation analysis. Results: Twenty-nine patients were included in the analysis (median [interquartile range] age: 24.0 [10.0] years). Systemic complement AP activation was evident by reduced median concentrations of C3 and C5, elevated sC5b-9, and normal C4, relative to reference ranges. C3 showed strong pairwise correlations with C5 and sC5b-9 (r = 0.80 and −0.73, respectively; p < 0.0001). Baseline Ba and FD concentrations were inversely correlated with eGFR (r = −0.83 and −0.87, respectively; p < 0.0001). Urinary concentrations of sC5b-9 were correlated with both plasma sC5b-9 and proteinuria (r = 0.69 and r = 0.83, respectively; p < 0.0001). Biopsy activity indices correlated strongly with biomarkers of systemic AP activation, including C3 (r = −0.76, p < 0.0001), whereas chronicity indices aligned more closely with eGFR (r = −0.57, p = 0.0021). Conclusion: Associations among complement biomarkers, kidney function, and kidney histology may add to the current understanding of C3G and assist with the characterization of patients with this heterogenous disease.
Published: 2022
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5. Dynein-mediated trafficking and degradation of nephrin in diabetic podocytopathy

Author: Hua Sun, Jillian Weidner, Chantal Allamargot, Robert Piper, Jason Misurac, and Carla Nester
Abstract: Diabetic nephropathy (DN) is characterized by increased endocytosis and degradation of nephrin, a protein that comprises the molecular sieve of the glomerular filtration barrier, but the key trafficking mechanism that connects the initial endocytic events and the homeostasis of nephrin is unknown. Our work implicates cytoplasmic dynein, a transport complex that is upregulated in DN, plays a critical role in triaging the endocytosed nephrin between recycling and proteolytic pathways. Using Nephroseq platform, our transcription analysis in public DN databases revealed dynein overexpression in human DN and diabetic mouse kidney, correlated with the severity of hyperglycemia and nephropathy. The increased expression of dynein subunits was confirmed in high glucose-treated podocytes and in glomeruli isolated from streptozotocin (STZ)-induced diabetic mice. Using live cell imaging, we illustrated that dynein-mediated post-endocytic sorting of nephrin was upregulated, resulting in accelerated nephrin degradation and disrupted nephrin recycling. In diabetic podocytopathy, Dynll1 is one of the most upregulated dynein components that was recruited to endocytosed nephrin. This was corroborated by observing enhanced Dynll1-nephrin colocalization in podocytes of diabetic patients, as well as dynein-mediated trafficking and degradation of nephrin in STZ-induced diabetic mice. Knockdown of Dynll1 attenuated lysosomal degradation of nephrin and promoted its recycling, suggesting the essential role of Dynll1 in dynein-mediated mistrafficking. Defining the role of dynein-mediated mistrafficking of nephrin in diabetes will not only fill the knowledge gap about the early events of DN, but also inspire novel therapeutics that target a broad spectrum of molecular events involved in the dynein-mediated trafficking.Translational StatementDiabetic nephropathy (DN), the leading cause of end stage kidney disease in the United States, is characterized by a podocytopathy with mistrafficking and depletion of the slit diaphragm protein nephrin, which in turn compromises the podocytes’ function in maintaining the glomerular filtration barrier. There is a critical need to define the trafficking mechanisms underlying the depletion of nephrin. Our work implicates cytoplasmic dynein, a trafficking complex that connects diabetes-triggered endocytosis with proteolytic pathways. Delineation of the dynein-driven pathogenesis of diabetic podocytopathy will inspire new therapies that potentially target a broad spectrum of molecules involved in dynein-mediated trafficking and degradation pathways.
Published: 2022
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6. Persistent Disease Activity in Patients With Long-Standing Glomerular Disease

Author: Elisa Delbarba, Maddalena Marasa, Pietro A. Canetta, Stacy E. Piva, Debanjana Chatterjee, Byum Hee Kil, Xueru Mu, Keisha L. Gibson, Michelle A. Hladunewich, Jonathan J. Hogan, Bruce A. Julian, Jason M. Kidd, Louis-Philippe Laurin, Patrick H. Nachman, Michelle N. Rheault, Dana V. Rizk, Neil S. Sanghani, Howard Trachtman, Scott E. Wenderfer, Ali G. Gharavi, Andrew S. Bomback, Wooin Ahn, Gerald B. Appel, Revekka Babayev, Ibrahim Batal, Eric Brown, Eric S. Campenot, Pietro Canetta, Brenda Chan, Vivette D. D’Agati, Hilda Fernandez, Bartosz Foroncewicz, Gian Marco Ghiggeri, William H. Hines, Namrata G. Jain, Krzysztof Kiryluk, Wai L. Lau, Fangming Lin, Francesca Lugani, Glen Markowitz, Sumit Mohan, Krzysztof Mucha, Thomas L. Nickolas, Stacy Piva, Jai Radhakrishnan, Maya K. Rao, Simone Sanna-Cherchi, Dominick Santoriello, Michael B. Stokes, Natalie Yu, Anthony M. Valeri, Ronald Zviti, Larry A. Greenbaum, William E. Smoyer, Amira Al-Uzri, Isa Ashoor, Diego Aviles, Rossana Baracco, John Barcia, Sharon Bartosh, Craig Belsha, Corinna Bowers, Michael C. Braun, Aftab Chishti, Donna Claes, Carl Cramer, Keefe Davis, Elif Erkan, Daniel Feig, Michael Freundlich, Rasheed Gbadegesin, Melisha Hanna, Guillermo Hidalgo, Tracy E. Hunley, Amrish Jain, Mahmoud Kallash, Myda Khalid, Jon B. Klein, Jerome C. Lane, John Mahan, Nisha Mathews, Carla Nester, Cynthia Pan, Larry Patterson, Hiren Patel, Adelaide Revell, Cynthia Silva, Rajasree Sreedharan, Tarak Srivastava, Julia Steinke, Katherine Twombley, Tetyana L. Vasylyeva, Donald J. Weaver, Craig S. Wong, Salem Almaani, Isabelle Ayoub, Milos Budisavljevic, Vimal Derebail, Huma Fatima, Ronald Falk, Agnes Fogo, Todd Gehr, Keisha Gibson, Dorey Glenn, Raymond Harris, Susan Hogan, Koyal Jain, J. Charles Jennette, Bruce Julian, Jason Kidd, H. Davis Massey, Amy Mottl, Patrick Nachman, Tibor Nadasdy, Jan Novak, Samir Parikh, Vincent Pichette, Caroline Poulton, Thomas Brian Powell, Matthew Renfrow, Dana Rizk, Brad Rovin, Virginie Royal, Manish Saha, Neil Sanghani, Sally Self, Sharon Adler, Charles Alpers, Raed Bou Matar, Elizabeth Brown, Daniel Cattran, Michael Choi, Katherine M. Dell, Ram Dukkipati, Fernando C. Fervenza, Alessia Fornoni, Crystal Gadegbeku, Patrick Gipson, Leah Hasely, Sangeeta Hingorani, Michelle Hladunewich, Jonathan Hogan, Lawrence B. Holzman, J. Ashley Jefferson, Kenar Jhaveri, Duncan B. Johnstone, Frederick Kaskel, Amy Kogan, Jeffrey Kopp, Richard Lafayette, Kevin V. Lemley, Laura Malaga-Dieguez, Kevin Meyers, Alicia Neu, Michelle Marie O’Shaughnessy, John F. O’Toole, Rulan Parekh, Heather Reich, Kimberly Reidy, Helbert Rondon, Kamalanathan K. Sambandam, John R. Sedor, David T. Selewski, Christine B. Sethna, Jeffrey Schelling, John C. Sperati, Agnes Swiatecka-Urban, Katherine R. Tuttle, Joseph Weisstuch, Suzanne Vento, Olga Zhdanova, Brenda Gillespie, Debbie S. Gipson, Peg Hill-Callahan, Margaret Helmuth, Emily Herreshoff, Matthias Kretzler, Chrysta Lienczewski, Sarah Mansfield, Laura Mariani, Cynthia C. Nast, Bruce M. Robinson, Jonathan Troost, Matthew Wladkowski, Jarcy Zee, Dawn Zinsser, and Lisa M. Guay-Woodford
Subjects: medicine.medical_specialty, glomerulonephropathy, glomerular disease, 030232 urology & nephrology, Disease, 030204 cardiovascular system & hematology, Nephropathy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Focal segmental glomerulosclerosis, Membranous nephropathy, Clinical Research, Internal medicine, Biopsy, medicine, Minimal change disease, focal segmental glomerulosclerosis, Creatinine, medicine.diagnostic_test, business.industry, membranous nephropathy, IgA nephropathy, medicine.disease, minimal change disease, chemistry, Nephrology, Cohort, business
Abstract: Introduction Glomerular diseases are characterized by variable disease activity over many years. We aimed to analyze the relationship between clinical disease activity and duration of glomerular disease. Methods Disease activity in adults with chronic minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy (IgAN; first diagnostic biopsy >5 years before enrollment; Of Longstanding Disease [OLD] cohort, n = 256) followed at Columbia University Medical Center (CUMC), was compared with disease activity of an internal and external cohort of patients with first diagnostic biopsy, Graphical abstract
Published: 2020
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7. Clinical Outcomes of Patients with C3G or IC-MPGN Treated with the Factor D Inhibitor Danicopan: Final Results from Two Phase 2 Studies

Author: Carla Nester, Gerald B. Appel, Andrew S. Bomback, Koenraad Peter Bouman, H. Terence Cook, Erica Daina, Bradley P. Dixon, Kara Rice, Nader Najafian, James Hui, Steven D. Podos, Craig B. Langman, Liz Lightstone, Samir V. Parikh, Matthew C. Pickering, C. John Sperati, Howard Trachtman, James Tumlin, Aiko PJ de Vries, Jack F.M. Wetzels, and Giuseppe Remuzzi
Subjects: Clinical trial, Factor D inhibitor, Nephrology, Danicopan, Complement alternative pathway, C3 glomerulopathy
Abstract: Introduction: C3 glomerulopathy (C3G) is an ultrarare, chronic and progressive nephropathy mediated by dysregulation of the alternative pathway of complement (AP), with poor prognosis and limited treatment options. Targeted inhibition of proximal AP through factor D (FD) blockade represents a rational treatment approach. We present two phase 2 proof-of-concept clinical studies of the orally active FD inhibitor danicopan in patients with C3G and immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) (NCT03369236 and NCT03459443). Methods: A double-blind, placebo-controlled study in patients with C3G and a single-arm, open-label study in patients with C3G or IC-MPGN treated with danicopan are reported. The studies evaluated pharmacokinetic/pharmacodynamic (PK/PD), efficacy, and safety outcomes. The co-primary endpoints were change from baseline in composite biopsy score and the proportion of patients with a 30% reduction in proteinuria relative to baseline at 6 or 12 months. Results: Optimal systemic concentrations of danicopan were not achieved for complete and sustained inhibition of AP, although there was evidence that blockade of FD reduced AP activity shortly after drug administration. Consequently, limited clinical response was observed in key efficacy endpoints. While stable disease or improvement from baseline was seen in some patients, response was not consistent. The data confirmed the favorable safety profile of danicopan. Conclusion: While demonstrating a favorable safety profile, danicopan resulted in incomplete and inadequately sustained inhibition of AP, probably due to limitations in its PK/PD profile in C3G, leading to lack of efficacy. Complete and sustained AP inhibition is required for a clinical response in patients with C3G.
Published: 2022

8. Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulopathy Network

Author: Dhruti P. Chen, Margaret E. Helmuth, Abigail R. Smith, Pietro A. Canetta, Isabelle Ayoub, Krzysztof Mucha, Mahmoud Kallash, Jeffrey B. Kopp, Rasheed Gbadegesin, Brenda W. Gillespie, Larry A. Greenbaum, Rulan S. Parekh, Tracy E. Hunley, C. John Sperati, David T. Selewski, Jason Kidd, Aftab Chishti, Kimberly Reidy, Amy K. Mottl, Debbie S. Gipson, Tarak Srivastava, Katherine E. Twombley, Wooin Ahn, Gerald Appel, Paul Appelbaum, Revekka Babayev, Andrew Bomback, Brenda Chan, Vivette Denise D’Agati, Samitri Dogra, Hilda Fernandez, Ali Gharavi, William Hines, Syed Ali Husain, Namrata Jain, Krzysztof Kiryluk, Fangming Lin, Maddalena Marasa, Glen Markowitz, Hila Milo Rasouly, Sumit Mohan, Nicola Mongera, Jordan Nestor, Thomas Nickolas, Jai Radhakrishnan, Maya Rao, Simone Sanna-Cherchi, Shayan Shirazian, Michael Barry Stokes, Natalie Uy, Anthony Valeri, Natalie Vena, Bartosz Foroncewicz, Barbara Moszczuk, Agnieszka Perkowska-Ptasińska, Gian Marco Ghiggeri, Francesca Lugani, Josephine Ambruzs, Helen Liapis, Rossana Baracco, Amrish Jain, Isa Ashoor, Diego Aviles, Sun-Young Ahn, Prasad Devarajan, Elif Erkan, Donna Claes, Hillarey Stone, Sherene Mason, Liliana Gomez-Mendez, Chia-shi Wang, Hong Yin, Yi Cai, Goebel Jens, Julia Steinke, Donald Weaver, Jerome Lane, Carl Cramer, Cindy Pan, Neil Paloian, Rajasree Sreedharan, Corinna Bowers, Mary Dreher, John Mahan, Samantha Sharpe, William Smoyer, Amira Al-Uzri, Sandra Iragorri, Myda Khalid, Craig Belsha, Joseph Alge, Michael Braun, A.C. Gomez, Scott Wenderfer, Tetyana Vasylyeva, Daniel Feig, Gabriel Cara Fuentes, Melisha Hannah, Carla Nester, Jon Klein, Chryso Katsoufis, Wacharee Seeherunvong, Michelle Rheault, Craig Wong, Nisha Mathews, John Barcia, Agnes Swiatecka-Urban, Sharon Bartosh, Vikas Dharnidharka, Joseph Gaut, Louis-Philippe Laurin, Virginie Royal, Anand Achanti, Milos Budisavljevic, Sally Self, Cybele Ghossein, Yonatan Peleg, Shikha Wadhwani, Salem Almaani, Tibor Nadasdy, null Samir, null Parikh, Brad Rovin, Anthony Chang, Huma Fatima, Bruce Julian, Jan Novak, Matthew Renfrow, Dana Rizk, Vimal Derebail, Ronald Falk, Keisha Gibson, Dorey Glenn, Susan Hogan, Koyal Jain, J. Charles Jennette, Caroline Poulton, Manish Kanti Saha, Agnes Fogo, Neil Sanghani, Selvaraj Muthusamy, Jeffrey Schelling, Jean Hou, Kevin Lemley, Warren Mika, Pierre Russo, Michelle Denburg, Amy Kogon, Kevin Meyers, Madhura Pradhan, Raed Bou Matar, John O’Toole, John Sedor, Christine Sethna, Suzanne Vento, Mohamed Atta, Serena Bagnasco, Alicia Neu, Sharon Adler, Tiane Dai, Ram Dukkipati, Fernando Fervenza, Sanjeev Sethi, Frederick Kaskel, Kaye Brathwaite, Joseph Weisstuch, Ming Wu, Olga Zhdanova, Jurgen Heymann, Meryl Waldman, Cheryl Winkler, Katherine Tuttle, Jill Krissberg, Richard Lafayette, Kamal Fahmeedah, Elizabeth Talley, Michelle Hladunewich, Carmen Avila-Casado, Daniel Cattran, Reich Heather, Philip Boll, Yelena Drexler, Alessia Fornoni, Patrick Gipson, Jeffrey Hodgin, Andrea Oliverio, Jon Hogan, Lawrence Holzman, Matthew Palmer, Gaia Coppock, Blaise Abromovitz, Michael Mortiz, Charles Alpers, J. Ashley Jefferson, Elizabeth Brown, Kamal Sambandam, Bethany Roehm, Bruce Robinson, Cynthia Nast, Laura Barisoni, Matthias Kretzler, Laura Mariani, and Lisa M. Guay-Woodford
Subjects: Nephrology
Abstract: Adolescent- and adult-onset disease minimal change disease (MCD) may have a clinical course distinct from childhood-onset disease. We characterized the course of children and adults with MCD in the Cure Glomerulopathy Network (CureGN) and assessed predictors of rituximab response.Prospective, multicenter, observational study.CureGN participants with proven MCD on biopsy.Age at disease onset. Initiation of RAAS blockade and immunosuppression including rituximab during the study period.Relapse and remission, change in eGFR and kidney failure.Remission and relapse probabilities are estimated using Kaplan-Meier curves and gap time recurrent event models. Linear regression models were used for the outcome of change in estimated glomerular filtration rate (eGFR). Cox proportional hazards models were used to estimate the association between rituximab administration and remission.304 childhood (≤12 years old), 49 adolescent (13-17 years old), and 201 adult onset (≥18 years) participants were included with 2.7-3.2 years of follow-up after enrollment. Children had longer time to biopsy (238 days vs. 23 in adolescents, and 36 in adults, p0.001) and were more likely to have received therapy prior to biopsy. Children were more likely to be treated with immunosuppression but not RAAS blockade. The rate of relapse was higher in childhood-onset versus adult-onset participants (hazard ratio (HR) 1.69 (95% confidence interval (CI) 1.29-2.21)). The probability of remission was also higher in childhood-onset disease (HR 1.33 (95%CI 1.02-1.72)). eGFR loss in all groups was minimal. Children were more likely to remit after rituximab than adolescents and adults (adjusted HR 2.1, p=0.003). Across all groups, glucocorticoid-sensitivity was associated with a greater likelihood of achieving complete remission after rituximab (adjusted HR 2.62, p=0.002).CureGN was limited to biopsy-proven disease. Comparisons of childhood to non-childhood cases of MCD may be subject to selection bias, given that childhood cases who are biopsied may be limited to those patients who are least responsive to initial therapy.Among patients with MCD who underwent kidney biopsy, there were differences in the course (relapse and remission) of childhood-onset compared to adolescent and adult-onset disease, as well as rituximab response.
Published: 2022

9. Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease

Author: Jill R. Krissberg, Michelle M. O’Shaughnessy, Abigail R. Smith, Margaret E. Helmuth, Salem Almaani, Diego H. Aviles, Kaye E. Brathwaite, Yi Cai, Daniel Cattran, Rasheed Gbadegesin, Dorey A. Glenn, Larry A. Greenbaum, Sandra Iragorri, Koyal Jain, Myda Khalid, Jason Kidd, Jeffrey Kopp, Richard Lafayette, Jerome C. Lane, Francesca Lugani, Jordan G. Nestor, Rulan S. Parekh, Kimberly Reidy, David T. Selewski, Christine B. Sethna, C. John Sperati, Katherine Tuttle, Katherine Twombley, Tetyana L. Vasylyeva, Donald J. Weaver, Scott E. Wenderfer, Keisha Gibson, Wooin Ahn, Gerald Appel, Paul Appelbaum, Revekka Babayev, Andrew Bomback, Eric Brown, Pietro Canetta, Lucrezia Carlassara, Brenda Chan, Vivette Denise D’Agati, Samitri Dogra, Hilda Fernandez, Ali Gharavi, William Hines, Syed Ali Husain, Krzysztof Kiryluk, Fangming Lin, Maddalena Marasa, Glen Markowitz, Hila Milo Rasouly, Sumit Mohan, Nicola Mongera, Thomas Nickolas, Jai Radhakrishnan, Maya Rao, Simone Sanna-Cherchi, Shayan Shirazian, Michael Barry Stokes, Natalie Uy, Anthony Valeri, Natalie Vena, Bartosz Foroncewicz, Barbara Moszczuk, Krzysztof Mucha, Agnieszka Perkowska-Ptasińska, Gian Marco Ghiggeri, Josephine Ambruzs, Helen Liapis, Rossana Baracco, Amrish Jain, Isa Ashoor, Tarak Srivastava, Sun-Young Ahn, Prasad Devarajan, Elif Erkan, Donna Claes, Hillarey Stone, Sherene Mason, Cynthia Silva, Liliana Gomez-Mendez, Chia-shi Wang, Hong (Julie) Yin, Goebel Jens, Julia Steinke, Carl Cramer, Cindy Pan, Rajasree Sreedharan, Corinna Bowers, Mary Dreher, Mahmoud Kallash, John Mahan, Samantha Sharpe, William Smoyer, Amira Al-Uzri, Craig Belsha, Michael Braun, A.C. Gomez, Daniel Feig, Gabriel Cara Fuentes, Melisha Hannah, Carla Nester, Aftab Chishti, Jon Klein, Chryso Katsoufis, Wacharee Seeherunvong, Michelle Rheault, Craig Wong, Nisha Mathews, John Barcia, Agnes Swiatecka-Urban, Sharon Bartosh, Tracy Hunley, Vikas Dharnidharka, Joseph Gaut, Louis-Philippe Laurin, Virginie Royal, Anand Achanti, Milos Budisavljevic, Sally Self, Cybele Ghossein, Shikha Wadhwani, Isabelle Ayoub, Tibor Nadasdy, Samir Parikh, Brad Rovin, Anthony Chang, Huma Fatima, Jan Novak, Matthew Renfrow, Dana Rizk, Dhruti Chen, Vimal Derebail, Ronald Falk, Susan Hogan, J. Charles Jennette, Amy Mottl, Caroline Poulton, Manish Kanti Saha, Agnes Fogo, Neil Sanghani, Hugh Massey, Selvaraj Muthusamy, Santhi Ganesan, Agustin Gonzalez-Vicente, Jeffrey Schelling, Jean Hou, Kevin Lemley, Warren Mika, Pierre Russo, Michelle Denburg, Amy Kogon, Kevin Meyers, Madhura Pradhan, Raed Bou Matar, John O’Toole, John Sedor, Serena Bagnasco, Alicia Neu, Sharon Adler, Tiane Dai, Ram Dukkipati, Fernando Fervenza, Sanjeev Sethi, Frederick Kaskel, Suzanne Vento, Joseph Weisstuch, Ming Wu, Olga Zhdanova, Jurgen Heymann, Meryl Waldman, Cheryl Winkler, Michelle Hladunewich, Carmen Avila-Casado, Reich Heather, Philip Boll, Yelena Drexler, Alessia Fornoni, Patrick Gipson, Jeffrey Hodgin, Andrew Oliverio, Jon Hogan, Lawrence Holzman, Matthew Palmer, Blaise Abromovitz, Michael Mortiz, Charles Alpers, J. Ashley Jefferson, Elizabeth Brown, Kamal Sambandam, Bruce Robinson, Cynthia Nast, Laura Barisoni, Brenda Gillespie, Deb Gipson, Maggie Hicken, Matthias Kretzler, Laura Mariani, and Lisa M. Guay-Woodford
Subjects: Nephrology
Abstract: The effects of race, ethnicity, socioeconomic status (SES), and disease severity on acute care utilization in patients with glomerular disease are unknown.Prospective cohort study.1,456 adults and 768 children with biopsy-proven glomerular disease enrolled in the Cure Glomerulonephropathy (CureGN) cohort.Race and ethnicity as a participant-reported social factor.Acute care utilization defined as hospitalizations or emergency department visits.Multivariable recurrent event proportional rate models were used to estimate associations between race and ethnicity and acute care utilization.Black or Hispanic participants had lower SES and more severe glomerular disease than White or Asian participants. Acute care utilization rates were 45.6, 29.5, 25.8, and 19.2 per 100 person-years in Black, Hispanic, White, and Asian adults, respectively, and 55.8, 42.5, 40.8, and 13.0, respectively, for children. Compared with the White race (reference group), Black race was significantly associated with acute care utilization in adults (rate ratio [RR], 1.76 [95% CI, 1.37-2.27]), although this finding was attenuated after multivariable adjustment (RR, 1.31 [95% CI, 1.03-1.68]). Black race was not significantly associated with acute care utilization in children; Asian race was significantly associated with lower acute care utilization in children (RR, 0.32 [95% CI 0.14-0.70]); no significant associations between Hispanic ethnicity and acute care utilization were identified.We used proxies for SES and lacked direct information on income, household unemployment, or disability.Significant differences in acute care utilization rates were observed across racial and ethnic groups in persons with prevalent glomerular disease, although many of these difference were explained by differences in SES and disease severity. Measures to combat socioeconomic disadvantage in Black patients and to more effectively prevent and treat glomerular disease are needed to reduce disparities in acute care utilization, improve patient wellbeing, and reduce health care costs.
Published: 2022

10. CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease

Author: Laura H. Mariani, Andrew S. Bomback, Pietro A. Canetta, Michael F. Flessner, Margaret Helmuth, Michelle A. Hladunewich, Jonathan J. Hogan, Krzysztof Kiryluk, Patrick H. Nachman, Cynthia C. Nast, Michelle N. Rheault, Dana V. Rizk, Howard Trachtman, Scott E. Wenderfer, Corinna Bowers, Peg Hill-Callahan, Maddalena Marasa, Caroline J. Poulton, Adelaide Revell, Suzanne Vento, Laura Barisoni, Dan Cattran, Vivette D’Agati, J. Charles Jennette, Jon B. Klein, Louis-Philippe Laurin, Katherine Twombley, Ronald J. Falk, Ali G. Gharavi, Brenda W. Gillespie, Debbie S. Gipson, Larry A. Greenbaum, Lawrence B. Holzman, Matthias Kretzler, Bruce Robinson, William E. Smoyer, Lisa M. Guay-Woodford, Wooin Ahn, Gerald B. Appel, Revekka Babayev, Ibrahim Batal, Eric Brown, Eric S. Campenot, Pietro Canetta, Lucrezia Carlassara, Brenda Chan, Debanjana Chatterjee, Vivette D. D’Agati, Elisa Delbarba, Samriti Dogra, Hilda Fernandez, Bartosz Foroncewicz, Gian Marco Ghiggeri, William H. Hines, S. Ali Husain, Namrata G. Jain, Pascale Khairallah, Byum Hee Kil, Anushya Jeyabalan, Wai L. Lau, Fangming Lin, Francesca Lugani, Glen Markowitz, Sumit Mohan, Xueru Mu, Krzysztof Mucha, Thomas L. Nickolas, Stacy Piva, Jai Radhakrishnan, Maya K. Rao, Renu Regunathan-Shenk, Simone Sanna-Cherchi, Dominick Santoriello, Shayan Shirazian, Michael B. Stokes, Natalie Yu, Anthony M. Valeri, Ronald Zviti, Amira Al-Uzri, Josephine Ambruzs, Isa Ashoor, Diego Aviles, Rossana Baracco, John Barcia, Sharon Bartosh, Craig Belsha, Michael C. Braun, Yi Cai, Vladimir Chernitskiy, Aftab Chishti, Donna Claes, Kira Clark, Carl Cramer, Keefe Davis, Amy Dutcher, Elif Erkan, Daniel Feig, Michael Freundlich, Joseph Gaut, Rasheed Gbadegesin, Melisha Hanna, Guillermo Hidalgo, David Hooper, Tracy E. Hunley, Amrish Jain, Mahmoud Kallash, Margo Kamel, Myda Khalid, Theresa Kump, Jerome C. Lane, Helen Liapis, John Mahan, Nisha Mathews, Carla Nester, Cynthia Pan, Larry Patterson, Hiren Patel, Alice Raad, Cynthia Silva, Rajasree Sreedharan, Tarak Srivastava, Julia Steinke, Susan Sumner, Tetyana L. Vasylyeva, Chia-shi Wang, Donald J. Weaver, Craig S. Wong, Hong Yin, Anand Achanti, Salem Almaani, Isabelle Ayoub, Milos Budisavljevic, Maggie D'Angelo, Vimal Derebail, Huma Fatima, Ronald Falk, Agnes Fogo, Keisha Gibson, Dorey Glenn, Susan Hogan, Koyal Jain, Bruce Julian, Jason Kidd, H. Davis Massey, Amy Mottl, Shannon Murphy, Tibor Nadasdy, Jan Novak, Samir Parikh, Caroline Poulton, Thomas Brian Powell, Bryce Reeve, Matthew Renfrow, Monica Reynolds, Dana Rizk, Brad Rovin, Virginie Royal, Manish Saha, Neil Sanghani, Sally Self, Sharon Adler, Nada Alachkar, Charles Alpers, Raed Bou Matar, Carmen Avila-Casado, Serena Bagnasco, Emily Brede, Elizabeth Brown, Daniel Cattran, Michael Choi, Gabriel Contreras, Katherine M. Dell, Darren Dewalt, Michelle Denburg, Ram Dukkipati, Fernando C. Fervenza, Alessia Fornoni, Crystal Gadegbeku, Patrick Gipson, Anny Gonzalez-Zea, Leah Hasely, Elizabeth Hendren, Sangeeta Hingorani, Michelle Hladunewich, Jonathan Hogan, Jean Hou, J. Ashley Jefferson, Kenar Jhaveri, Duncan B. Johnstone, Frederick Kaskel, Amy Kogan, Jeffrey Kopp, Richard Lafayette, Kevin V. Lemley, Laura Malaga-Dieguez, Kevin Meyers, Alicia Neu, Michelle Marie O'Shaughnessy, John F. O’Toole, Andrea Oliverio, Matthew Palmer, Rulan Parekh, Renee Pitter, Heather Reich, Kimberly Reidy, Helbert Rondon, Kamalanathan K. Sambandam, Matthew Sampson, John R. Sedor, David T. Selewski, Christine B. Sethna, Jeffrey Schelling, John C. Sperati, Agnes Swiatecka-Urban, Katherine R. Tuttle, Meryl Waldman, Joseph Weisstuch, Roger Wiggins, David Williams, Cheryl Winkler, Eric Young, Olga Zhdanova, Charlotte Beil, Richard Eikstadt, Brenda Gillespie, John Graff, Stephen Hewitt, Emily Herreshoff, Chrysta Lienczewski, Sarah Mansfield, Laura Mariani, Keith McCullough, Nicholas Moore, Bruce M. Robinson, Melissa Sexton, Jonathan Troost, Matthew Wladkowski, Jarcy Zee, and Dawn Zinsser
Subjects: Adult, Male, medicine.medical_specialty, Henoch-Schonlein purpura, Adolescent, 030232 urology & nephrology, Disease, Glomerulonephritis, Membranous, Risk Assessment, Severity of Illness Index, Article, Nephropathy, Diagnosis, Differential, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Focal segmental glomerulosclerosis, Glomerulonephritis, Sex Factors, Membranous nephropathy, Internal medicine, medicine, Humans, Minimal change disease, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Child, Academic Medical Centers, business.industry, Glomerulosclerosis, Focal Segmental, Nephrosis, Lipoid, Biopsy, Needle, Age Factors, Glomerulonephritis, IGA, Middle Aged, medicine.disease, Prognosis, Immunohistochemistry, Survival Analysis, Nephrology, Multivariate Analysis, Disease Progression, Linear Models, Kidney Failure, Chronic, Female, business, Kidney disease
Abstract: Rationale & Objectives Glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) nephropathy, share clinical presentations, yet result from multiple biological mechanisms. Challenges to identifying underlying mechanisms, biomarkers, and new therapies include the rarity of each diagnosis and slow progression, often requiring decades to measure the effectiveness of interventions to prevent end-stage kidney disease (ESKD) or death. Study Design Multicenter prospective cohort study. Setting & Participants Cure Glomerulonephropathy (CureGN) will enroll 2,400 children and adults with minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (including IgA vasculitis) and a first diagnostic kidney biopsy within 5 years. Patients with ESKD and those with secondary causes of glomerular disease are excluded. Exposures Clinical data, including medical history, medications, family history, and patient-reported outcomes, are obtained, along with a digital archive of kidney biopsy images and blood and urine specimens at study visits aligned with clinical care 1 to 4 times per year. Outcomes Patients are followed up for changes in estimated glomerular filtration rate, disease activity, ESKD, and death and for nonrenal complications of disease and treatment, including infection, malignancy, cardiovascular, and thromboembolic events. Analytical Approach The study design supports multiple longitudinal analyses leveraging the diverse data domains of CureGN and its ancillary program. At 2,400 patients and an average of 2 years' initial follow-up, CureGN has 80% power to detect an HR of 1.4 to 1.9 for proteinuria remission and a mean difference of 2.1 to 3.0mL/min/1.73m2 in estimated glomerular filtration rate per year. Limitations Current follow-up can only detect large differences in ESKD and death outcomes. Conclusions Study infrastructure will support a broad range of scientific approaches to identify mechanistically distinct subgroups, identify accurate biomarkers of disease activity and progression, delineate disease-specific treatment targets, and inform future therapeutic trials. CureGN is expected to be among the largest prospective studies of children and adults with glomerular disease, with a broad goal to lessen disease burden and improve outcomes.
Published: 2018

11. Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study

Author: David T. Selewski, Josephine M. Ambruzs, Gerald B. Appel, Andrew S. Bomback, Raed Bou Matar, Yi Cai, Daniel C. Cattran, Aftab S. Chishti, Vivette D. D'Agati, Cynthia J. D'Alessandri-Silva, Rasheed A. Gbadegesin, Jonathan J. Hogan, Sandra Iragorri, J. Charles Jennette, Bruce A. Julian, Myda Khalid, Richard A. Lafayette, Helen Liapis, Francesca Lugani, Sarah A. Mansfield, Sherene Mason, Patrick H. Nachman, Cynthia C. Nast, Carla M. Nester, Damien G. Noone, Jan Novak, Michelle M. O'Shaughnessy, Heather N. Reich, Michelle N. Rheault, Dana V. Rizk, Manish K. Saha, Neil S. Sanghani, C. John Sperati, Rajasree Sreedharan, Tarak Srivastava, Agnieszka Swiatecka-Urban, Katherine Twombley, Tetyana L. Vasylyeva, Donald J. Weaver, Hong Yin, Jarcy Zee, Ronald J. Falk, Ali G. Gharavi, Brenda W. Gillespie, Debbie S. Gipson, Larry A. Greenbaum, Lawrence B. Holzman, Matthias Kretzler, Bruce M. Robinson, William E. Smoyer, Michael Flessner, Lisa M. Guay-Woodford, Krzysztof Kiryluk, Ali Gharavi, Wooin Ahn, Rupali S. Avasare, Revekka Babayev, Ibrahim Batal, Eric Brown, Eric S. Campenot, Pietro Canetta, Brenda Chan, Vivette D. D’Agati, Hilda Fernandez, Bartosz Foroncewicz, Gian Marco Ghiggeri, William H. Hines, Namrata G. Jain, Fangming Lin, Maddalena Marasa, Glen Markowitz, Sumit Mohan, Krzysztof Mucha, Thomas L. Nickolas, Jai Radhakrishnan, Maya K. Rao, Renu Regunathan-Shenk, Simone Sanna-Cherchi, Dominick Santoriello, Michael B. Stokes, Natalie Yu, Anthony M. Valeri, Ronald Zviti, Amira Al-Uzri, Isa Ashoor, Diego Aviles, Rossana Baracco, John Barcia, Sharon Bartosh, Craig Belsha, Michael C. Braun, Aftab Chishti, Donna Claes, Carl Cramer, Keefe Davis, Elif Erkan, Daniel Feig, Michael Freundlich, Melisha Hanna, Guillermo Hidalgo, Amrish Jain, Mahmoud Kallash, Jerome C. Lane, John Mahan, Nisha Mathews, Carla Nester, Cynthia Pan, Hiren Patel, Adelaide Revell, Julia Steinke, Scott E. Wenderfer, Craig S. Wong, Ronald Falk, William Cook, Vimal Derebail, Agnes Fogo, Adil Gasim, Todd Gehr, Raymond Harris, Jason Kidd, Louis-Philippe Laurin, Will Pendergraft, Vincent Pichette, Thomas Brian Powell, Matthew B. Renfrow, Virginie Royal, Sharon Adler, Charles Alpers, Elizabeth Brown, Daniel Cattran, Michael Choi, Katherine M. Dell, Ram Dukkipati, Fernando C. Fervenza, Alessia Fornoni, Crystal Gadegbeku, Patrick Gipson, Leah Hasely, Sangeeta Hingorani, Michelle A. Hladunewich, Jonathan Hogan, J. Ashley Jefferson, Kenar Jhaveri, Duncan B. Johnstone, Frederick Kaskel, Amy Kogan, Jeffrey Kopp, Kevin V. Lemley, Laura Malaga- Dieguez, Kevin Meyers, Alicia Neu, Michelle Marie O’Shaughnessy, John F. O’Toole, Rulan Parekh, Heather Reich, Kimberly Reidy, Helbert Rondon, Kamalanathan K. Sambandam, John R. Sedor, Christine B. Sethna, Jeffrey Schelling, Agnes Swiatecka-Urban, Howard Trachtman, Katherine R. Tuttle, Joseph Weisstuch, Olga Zhdanova, Brenda Gillespie, Laura Barisoni, Sarah Mansfield, Laura Mariani, and Matthew Wladkowski
Subjects: medicine.medical_specialty, 030232 urology & nephrology, Disease, 030204 cardiovascular system & hematology, urologic and male genital diseases, Nephropathy, 03 medical and health sciences, 0302 clinical medicine, Focal segmental glomerulosclerosis, Membranous nephropathy, Clinical Research, Internal medicine, IgA nephropathy (IgAN), Biopsy, medicine, Minimal change disease, medicine.diagnostic_test, business.industry, IgA vasculitis (IgAV), medicine.disease, 3. Good health, IgA vasculitis, Nephrology, Cohort, business, glomerulonephritis, Henoch-Schönlein purpura (HSP)
Abstract: Introduction The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including IgA vasculitis (IgAV). This study describes the clinical characteristics and treatment patterns in the IgA cohort, including comparisons between IgAN versus IgAV and adult versus pediatric patients. Methods Patients with a diagnostic kidney biopsy within 5 years of screening were eligible to join CureGN. This is a descriptive analysis of clinical and treatment data collected at the time of enrollment. Results A total of 667 patients (506 IgAN, 161 IgAV) constitute the IgAN/IgAV cohort (382 adults, 285 children). At biopsy, those with IgAV were younger (13.0 years vs. 29.6 years, P < 0.001), more frequently white (89.7% vs. 78.9%, P = 0.003), had a higher estimated glomerular filtration rate (103.5 vs. 70.6 ml/min per 1.73 m2, P < 0.001), and lower serum albumin (3.4 vs. 3.8 g/dl, P < 0.001) than those with IgAN. Adult and pediatric individuals with IgAV were more likely than those with IgAN to have been treated with immunosuppressive therapy at or prior to enrollment (79.5% vs. 54.0%, P < 0.001). Conclusion This report highlights clinical differences between IgAV and IgAN and between children and adults with these diagnoses. We identified differences in treatment with immunosuppressive therapies by disease type. This description of baseline characteristics will serve as a foundation for future CureGN studies.
Published: 2018

12. Health-related quality of life in glomerular disease

Author: Pietro A. Canetta, Jonathan P. Troost, Shannon Mahoney, Amy J. Kogon, Noelle Carlozzi, Sharon M. Bartosh, Yi Cai, T. Keefe Davis, Hilda Fernandez, Alessia Fornoni, Rasheed A. Gbadegesin, Emily Herreshoff, John D. Mahan, Patrick H. Nachman, David T. Selewski, Christine B. Sethna, Tarak Srivastava, Katherine R. Tuttle, Chia-shi Wang, Ronald J. Falk, Ali G. Gharavi, Brenda W. Gillespie, Larry A. Greenbaum, Lawrence B. Holzman, Matthias Kretzler, Bruce M. Robinson, William E. Smoyer, Lisa M. Guay-Woodford, Bryce Reeve, Debbie S. Gipson, Wooin Ahn, Gerald B. Appel, Revekka Babayev, Ibrahim Batal, Andrew S. Bomback, Eric Brown, Eric S. Campenot, Pietro Canetta, Lucrezia Carlassara, Brenda Chan, Debanjana Chatterjee, Vivette D. D’Agati, Elisa Delbarba, Samriti Dogra, Bartosz Foroncewicz, Gian Marco Ghiggeri, William H. Hines, S. Ali Husain, Namrata G. Jain, Pascale Khairallah, Byum Hee Kil, Krzysztof Kiryluk, Anushya Jeyabalan, Wai L. Lau, Fangming Lin, Francesca Lugani, Maddalena Marasa, Glen Markowitz, Sumit Mohan, Xueru Mu, Krzysztof Mucha, Thomas L. Nickolas, Stacy Piva, Jai Radhakrishnan, Maya K. Rao, Regunathan-Shenk Renu, Simone Sanna-Cherchi, Dominick Santoriello, Shayan Shirazian, Michael B. Stokes, Natalie Uy, Anthony M. Valeri, Amira Al-Uzri, Josephine Ambruzs, Isa Ashoor, Diego Aviles, Rossana Baracco, John Barcia, Sharon Bartosh, Craig Belsha, Corinna Bowers, Michael C. Braun, Vladimir Chernitskiy, Aftab Chishti, Donna Claes, Kira Clark, Carl Cramer, Keefe Davis, Elif Erkan, Daniel Feig, Michael Freundlich, Joseph Gaut, Rasheed Gbadegesin, Melisha Hanna, Guillermo Hidalgo, David Hooper, Tracy E. Hunley, Amrish Jain, Mahmoud Kallash, Margo Kamel, Myda Khalid, Jon B. Klein, Theresa Kump, Jerome C. Lane, Helen Liapis, John Mahan, Carla Nester, Cynthia Pan, Larry Patterson, Hiren Patel, Alice Raad, Adelaide Revell, Michelle N. Rheault, Cynthia Silva, Rajasree Sreedharan, Julia Steinke, Susan Sumner, Katherine Twombley, Scott E. Wenderfer, Tetyana L. Vasylyeva, Donald J. Weaver, Craig S. Wong, Hong Yin, Anand Achanti, Salem Almaani, Isabelle Ayoub, Milos Budisavljevic, Maggie D’Angelo, Huma Fatima, Ronald Falk, Agnes Fogo, Keisha Gibson, Dorey Glenn, Susan Hogan, J. Charles Jennette, Bruce Julian, Jason Kidd, Louis-Philippe Laurin, H. Davis Massey, Amy Mottl, Shannon Murphy, Patrick Nachman, Tibor Nadasdy, Jan Novak, Samir Parikh, Caroline Poulton, Thomas Brian Powell, Matthew Renfrow, Monica Reynolds, Dana Rizk, Brad Rovin, Virginie Royal, Neil Sanghani, Sally Self, Sharon Adler, Nada Alachkar, Charles Alpers, Raed Bou Matar, Carmen Avila-Casado, Serena Bagnasco, Emily Brede, Elizabeth Brown, Daniel Cattran, Michael Choi, Katherine M. Dell, Darren Dewalt, Michelle Denburg, Ram Dukkipati, Fernando C. Fervenza, Crystal Gadegbeku, Patrick Gipson, Anny Gonzalez-Zea, Leah Hasely, Elizabeth Hendren, Sangeeta Hingorani, Michelle Hladunewich, Jonathan Hogan, Jean Hou, J. Ashley Jefferson, Kenar Jhaveri, Duncan B. Johnstone, Frederick Kaskel, Amy Kogan, Jeffrey Kopp, Richard Lafayette, Kevin V. Lemley, Laura Malaga-Dieguez, Kevin Meyers, Alicia Neu, Michelle Marie O'Shaughnessy, John F. O’Toole, Andrea Oliverio, Matthew Palmer, Rulan Parekh, Renee Pitter, Heather Reich, Kimberly Reidy, Helbert Rondon, Kamalanathan K. Sambandam, Matthew Sampson, John R. Sedor, Jeffrey Schelling, John C. Sperati, Agnes Swiatecka-Urban, Howard Trachtman, Meryl Waldman, Joseph Weisstuch, Roger Wiggins, David Williams, Cheryl Winkler, Suzanne Vento, Eric Young, Olga Zhdanova, Laura Barisoni, Charlotte Beil, Richard Eikstadt, Brenda Gillespie, John Graff, Stephen Hewitt, Peg Hill-Callahan, Margaret Helmuth, Chrysta Lienczewski, Sarah Mansfield, Laura Mariani, Keith McCullough, Nicholas Moore, Cynthia C. Nast, Melissa Sexton, Jonathan Troost, Matthew Wladkowski, Jarcy Zee, and Dawn Zinsser
Subjects: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Adolescent, 030232 urology & nephrology, Renal function, Article, Nephropathy, 03 medical and health sciences, 0302 clinical medicine, Focal segmental glomerulosclerosis, Glomerulonephritis, Membranous nephropathy, Quality of life, Internal medicine, medicine, Edema, Humans, Minimal change disease, Longitudinal Studies, Child, Aged, business.industry, Middle Aged, medicine.disease, Obesity, humanities, 030104 developmental biology, Nephrology, Quality of Life, Anxiety, Female, Self Report, medicine.symptom, business
Abstract: There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). We assessed the relationship between HRQOL and demographic and clinical variables in 478 children and 1115 adults at the time of enrollment into CureGN. Domains measured by PROMIS items included global assessments of health, mobility, anxiety, fatigue, and sleep impairment, as well as a derived composite measure incorporating all measured domains. Multivariable models were created that explained 7 to 32% of variance in HRQOL. Patient-reported edema consistently had the strongest and most robust association with each measured domain of HRQOL in multivariable analysis (adjusted β [95% CI] for composite PROMIS score in children, -5.2 [-7.1 to -3.4]; for composite PROMIS score in adults, -6.1 [-7.4 to -4.9]). Female sex, weight (particularly obesity), and estimated glomerular filtration rate were also associated with some, but not all, domains of HRQOL. Primary diagnosis, disease duration, and exposure to immunosuppression were not associated with HRQOL after adjustment. Sensitivity analyses and interaction testing demonstrated no significant association between disease duration or immunosuppression and any measured domain of HRQOL. Thus, patient-reported edema has a consistent negative association with HRQOL in patients with primary glomerular diseases, with substantially greater impact than other demographic and clinical variables.
Published: 2018

13. Clinical Pediatric Nephrology

Author: Michele Mietus-Snyder, Carla Nester, Hans Pohl, Prasad Devarajan, and Danniele Holanda
Subjects: Chemistry, Acid–base homeostasis, Cell biology
Published: 2016
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14. A study of primary care teaching comparing academic and community-based settings

Author: Philip A. Masters and Carla Nester
Subjects: Community based, medicine.medical_specialty, business.industry, Teaching, Public health, Professional qualification, education, Primary health care, Physicians, Family, Hospitals, Community, Original Articles, Primary care, Pennsylvania, Hospitals community, Nursing, Preceptorship, ComputingMilieux_COMPUTERSANDEDUCATION, Internal Medicine, Humans, Medicine, Practice Patterns, Physicians', Hospitals, Teaching, business, Education, Medical, Undergraduate
Abstract: To compare teaching activity and content between academic and community-based practices used in third year medical student primary care training.Academic and community-based primary care practices participating in third-year internal medicine, family medicine, and primary care core clerkships.Five-hundred thirteen preceptor-student encounters involving 32 preceptors and 26 third-year medical students were evaluated.Student-preceptor pairs collected a convenience sample of data from shared patient encounters. Preceptors recorded the content of teaching interventions, and students independently documented learning points received for each clinical encounter.Comparison of problem exposure, frequency and content of teaching interventions, and the effect of patient complexity and patient care workload on teaching frequency was made between the academic and community-based practices. Several small differences were found in the frequency of clinical problem exposure between the 2 settings. The frequency and focus of teaching interventions did not differ by practice type. Teaching by community-based preceptors tended to decrease with increased patient care workload, but increased in academically based practices.Although several differences exist between educational experiences in community- and academically based primary care practices, they appear to be minor and of minimal educational significance.
Published: 2001
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15. An audit analysis of a guideline for the investigation and initial therapy of diarrhea negative (atypical) hemolytic uremic syndrome

Author: Johnson S, Stojanovic J, Ariceta G, Bitzan M, Besbas N, Frieling M, Karpman D, Landau D, Langman C, Licht C, Pecoraro C, Riedl M, Siomou E, van de Kar N Walle JV, Loirat C, Taylor CM, Anne-Laure Adra, Klaus Arbeiter, Yelda Bilginer, Heiko Billing, Maria Bitsori, Bernard Boudailliez, Francisco de la Cerda – Ojeda, Gérard Champion, Amit Dagan, Bradley Dixon, Philippe Eckart, Israel Eisenstein, Arnaud Garnier, Clara Gomes, Karsten Häffner, Jerome Harambat, Carol Inward, Rafael Krmar, Theresa Kwon, Anne-Laure Lapeyraque, Sebastian Loos, Meeta Malik, Mignon McCulloch, David Milford, Danko Milosevic, Carla Nester, François Nobili, Pedro J Ortega, Fotios Papachristou, Antonia Peña - Carrión, Ludmila Podracká, Nikoleta Printza, Bruno Ranchin, Christopher Reid, Caroline Rousset-Rouvière, Rémi Salomon, Anne-Laure Sellier-Leclerc, James Springate, Sophie Taque, Despoina Tramma, Sibylle Tschumi, Ulrike Walden, Kay Tyerman, Aoife Waters, and Donald J Weaver Jr
Subjects: Male, Nephrology, Clinical audit, medicine.medical_specialty, Pediatrics, Thrombotic microangiopathy, Adolescent, medicine.medical_treatment, atypical hemolytic-uremic syndrome, alternative complement pathway, plasmapheresis, complement disregulation, chronic kidney disease, thrombotic microangiopathy, urologic and male genital diseases, Surveys and Questionnaires, hemic and lymphatic diseases, Internal medicine, Atypical hemolytic uremic syndrome, medicine, Humans, Child, Atypical Hemolytic Uremic Syndrome, Clinical Audit, business.industry, Infant, Newborn, Infant, Guideline, Eculizumab, medicine.disease, female genital diseases and pregnancy complications, Diarrhea, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], Child, Preschool, Practice Guidelines as Topic, Pediatrics, Perinatology and Child Health, Immunology, Female, Plasmapheresis, Guideline Adherence, medicine.symptom, business, medicine.drug
Abstract: Item does not contain fulltext BACKGROUND: In 2009, the European Paediatric Study Group for Haemolytic Uraemic Syndrome (HUS) published a clinical practice guideline for the investigation and initial therapy of diarrhea-negative HUS (now more widely referred to as atypical HUS, aHUS). The therapeutic component of the guideline (comprising early, high-volume plasmapheresis) was derived from anecdotal evidence and expert consensus, and the authors committed to auditing outcome. METHODS: Questionnaires were distributed to pediatric nephrologists across Europe, North America, and the Middle East, who were asked to complete one questionnaire per patient episode of aHUS between July 1, 2009 and December 31, 2010. Comprehensive, anonymous demographic and clinical data were collected. RESULTS: Seventy-one children were reported with an episode of aHUS during the audit period. Six cases occurred on a background of influenza A H1N1 infection. Of 71 patients, 59 (83 %) received plasma therapy within the first 33 days, of whom ten received plasma infusion only. Complications of central venous catheters occurred in 16 out of 51 patients with a catheter in-situ (31 %). Median time to enter hematological remission was 11.5 days, and eight of 71 (11 %) patients did not enter hematological remission by day 33. Twelve patients (17 %) remained dialysis dependent at day 33. CONCLUSIONS: This audit provides a snapshot of the early outcome of a group of children with aHUS in the months prior to more widespread use of eculizumab. 01 oktober 2014
Published: 2014

16. Cystatin C

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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17. Catheter-Associated Urinary Tract Infection

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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18. Conscious Sedation

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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19. Congenital Heart Disease in Children

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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20. Craniocervical Vertical Distraction Injury

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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21. Cocaine

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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22. Cauda Equina Syndrome

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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23. Carbonic Anhydrase Inhibitors

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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24. Coxiella burnetii

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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25. Clostridium difficile-Associated Disease

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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26. Central Spinal Cord Syndrome

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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27. Cardiogenic Pulmonary Edema

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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28. Capsaicin- 8-methyl-N-vanillyl-6-nonenamide

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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29. Cryptococcus gattii

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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30. Clinical Pulmonary Infection Score (CPIS)

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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31. Chest Infection

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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32. Catheter-Associated Bloodstream Infection

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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33. Coma depasse

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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34. Cystic Echinococcosis (CE)

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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35. Calcium Channel Antagonist Poisoning

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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36. Cardiac Steroids and Glycoside Toxicity

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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37. Closure Time (PFA)

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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38. Cardiac Output, Measurements

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Subjects: medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiology, End-diastolic volume, business, End-systolic volume, Pulse pressure
Published: 2012
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39. Cardiac Troponin T

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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40. Critical Illness Myopathy and/or Neuropathy (CRIMYNE)

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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41. Continuous Veno-venous Hemodiafiltration (CVVHDF)

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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42. Clostridium difficile Infection

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
Full Text: View/download PDF

43. Closed Head Injury (CHI)

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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44. Cerebrospinal Fluid Pressure Monitoring

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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45. Contact Precautions

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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46. Capillary Refill

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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47. Creatinine and Creatinine Clearance in Children

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
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48. Complicated Intra-abdominal Infections

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
Full Text: View/download PDF

49. Contrast Nephropathy

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
Full Text: View/download PDF

50. Clostridium difficile Diarrhea

Author: Adeel Abbasi, Francis DeRoos, José Artur Paiva, J.M. Pereira, Brian G. Harbrecht, Donald P. Levine, Patricia D. Brown, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Jonathan R. Egan, Marino S. Festa, Chadwick D. Miller, Daniel W. Entrikin, W. Gregory Hundley, James McCord, Giorgio Della Rocca, Maria Gabriella Costa, Nima Majlesi, Diane P. Calello, Richard D. Shih, Dominic W. K. Spray, Raghu R. Seethala, Benjamin S. Abella, Claudio Ronco, Mikko Haapio, Nagesh S. Anavekar, Andrew A. House, Rinaldo Bellomo, Andrew M. Morris, Scott E. Bell, Kathryn M. Beauchamp, Sarah E. Pinski, Arianne Boylan, Jens-Peter Witt, Todd F. VanderHeiden, Philip F. Stahel, Gorazd Voga, José Rodolfo Rocco, Daniel B. Craig, Suzanne M. Shepherd, William H. Shoff, Samuel Waller, Sonia Labeau, Dominique Vandijck, Stijn Blot, John Tobias Nagurney, Donald D. Trunkey, John C. Mayberry, Christopher M. Watson, Robert G. Sawyer, Laura J. Moore, Ares Krishna Menon, Rüdiger Autschbach, Werner Baulig, Donat R. Spahn, Michael T. Ganter, Jeffry L. Kashuk, Judd E. Hollander, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Lewis J. Kaplan, Roselle Crombie, Gina Luckianow, Derrick Sun, John H. Burton, Eric A. J. Hoste, Zhongping Huang, William R. Clark, Harold Litt, Jeremy Cordingley, Thomas J. Marrie, Lucido L. Ponce, Claudia S. Robertson, Carla Nester, Patrick D. Brophy, Anders Kallner, Brent P. Goodman, Oliver L. Hung, and Stefan Herget-Rosenthal
Published: 2012
Full Text: View/download PDF

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