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Non-coding RNAs (ncRNAs) and the innate immune system are closely related, acting as defense mechanisms and regulating gene expression and innate immunity. Both are modulators in the initiation, development and progression of cancer. We aimed to review the major types of ncRNAs, including small interfering RNAs (siRNAs), microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and long non-coding RNAs (lncRNAs), with a focus on cancer, innate immunity, and inflammation. We found that ncRNAs are closely related to innate immunity, epigenetics, chronic inflammation, and cancer and share properties such as inducibility, specificity, memory, and transfer. These similarities and interrelationships suggest that ncRNAs and modulators of trained immunity, together with the control of chronic inflammation, can be combined to develop novel therapeutic approaches for personalized cancer treatment. In conclusion, the close relationship between ncRNAs, the innate immune system, and inflammation highlights their importance in cancer pathways and their potential as targets for novel therapeutic strategies.

Neutrophils, which constitute the most abundant leukocytes in human blood, emerge as crucial players in the induction of endothelial cell death and the modulation of endothelial cell responses under both physiological and pathological conditions. The hallmark of preeclampsia is endothelial dysfunction induced by systemic inflammation, in which neutrophils, particularly through the formation of neutrophil extracellular traps (NETs), play a pivotal role in the development and perpetuation of endothelial dysfunction and the hypertensive state. Considering the potential of numerous pharmaceutical agents to attenuate NET formation (NETosis) in preeclampsia, a comprehensive assessment of the extensively studied candidates becomes imperative. This review aims to identify mechanisms associated with the induction and negative regulation of NETs in the context of preeclampsia. We discuss potential drugs to modulate NETosis, such as NF-κβ inhibitors, vitamin D, and aspirin, and their association with mutagenicity and genotoxicity. Strong evidence supports the notion that molecules involved in the activation of NETs could serve as promising targets for the treatment of preeclampsia.

Abstract Numerous repositioned drugs have been sought to decrease the severity of SARS-CoV-2 infection. It is known that among its physicochemical properties, Ursodeoxycholic Acid (UDCA) has a reduction in surface tension and cholesterol solubilization, it has also been used to treat cholesterol gallstones and viral hepatitis. In this study, molecular docking was performed with the SARS-CoV-2 Spike protein and UDCA. In order to confirm this interaction, we used Molecular Dynamics (MD) in “SARS-CoV-2 Spike protein-UDCA”. Using another system, we also simulated MD with six UDCA residues around the Spike protein at random, naming this “SARS-CoV-2 Spike protein-6UDCA”. Finally, we evaluated the possible interaction between UDCA and different types of membranes, considering the possible membrane conformation of SARS-CoV-2, this was named “SARS-CoV-2 membrane-UDCA”. In the “SARS-CoV-2 Spike protein-UDCA”, we found that UDCA exhibits affinity towards the central region of the Spike protein structure of − 386.35 kcal/mol, in a region with 3 alpha helices, which comprises residues from K986 to C1032 of each monomer. MD confirmed that UDCA remains attached and occasionally forms hydrogen bonds with residues R995 and T998. In the presence of UDCA, we observed that the distances between residues atoms OG1 and CG2 of T998 in the monomers A, B, and C in the prefusion state do not change and remain at 5.93 ± 0.62 and 7.78 ± 0.51 Å, respectively, compared to the post-fusion state. Next, in “SARS-CoV-2 Spike protein-6UDCA”, the three UDCA showed affinity towards different regions of the Spike protein, but only one of them remained bound to the region between the region's heptad repeat 1 and heptad repeat 2 (HR1 and HR2) for 375 ps of the trajectory. The RMSD of monomer C was the smallest of the three monomers with a value of 2.89 ± 0.32, likewise, the smallest RMSF was also of the monomer C (2.25 ± 056). In addition, in the simulation of “SARS-CoV-2 membrane-UDCA”, UDCA had a higher affinity toward the virion-like membrane; where three of the four residues remained attached once they were close (5 Å, to the centre of mass) to the membrane by 30 ns. However, only one of them remained attached to the plasma-like membrane and this was in a cluster of cholesterol molecules. We have shown that UDCA interacts in two distinct regions of Spike protein sequences. In addition, UDCA tends to stay bound to the membrane, which could potentially reduce the internalization of SARS-CoV-2 in the host cell.

It is generally understood that the entry of semen into the female reproductive tract provokes molecular and cellular changes facilitating conception and pregnancy. We show a broader picture of the participation of prostaglandins in the fertilization, implantation and maintenance of the embryo. A large number of cells and molecules are related to signaling networks, which regulate tolerance to implantation and maintenance of the embryo and fetus. In this work, many of those cells and molecules are analyzed. We focus on platelets, polymorphonuclear leukocytes, and group 2 innate lymphoid cells involved in embryo tolerance in order to have a wider view of how prostaglandins participate. The combination of platelets and neutrophil extracellular traps (Nets), uterine innate lymphoid cells (uILC), Treg cells, NK cells, and sex hormones have an important function in immunological tolerance. In both animals and humans, the functions of these cells can be regulated by prostaglandins and soluble factors in seminal plasma to achieve an immunological balance, which maintains fetal-maternal tolerance. Prostaglandins, such as PGI2 and PGE2, play an important role in the suppression of the previously mentioned cells. PGI2 inhibits platelet aggregation, in addition to IL-5 and IL-13 expression in ILC2, and PGE2 inhibits some neutrophil functions, such as chemotaxis and migration processes, leukotriene B4 (LTB4) biosynthesis, ROS production, and the formation of extracellular traps, which could help prevent trophoblast injury and fetal loss. The implications are related to fertility in female when seminal fluid is deposited in the vagina or uterus.

SARS-CoV-2 contains certain molecules that are related to the presence of immunothrombosis. Here, we review the pathogen and damage-associated molecular patterns. We also study the imbalance of different molecules participating in immunothrombosis, such as tissue factor, factors of the contact system, histones, and the role of cells, such as endothelial cells, platelets, and neutrophil extracellular traps. Regarding the pathogenetic mechanism, we discuss clinical trials, case-control studies, comparative and translational studies, and observational studies of regulatory or inhibitory molecules, more specifically, extracellular DNA and RNA, histones, sensors for RNA and DNA, as well as heparin and heparinoids. Overall, it appears that a network of cells and molecules identified in this axis is simultaneously but differentially affecting patients at different stages of COVID-19, and this is characterized by endothelial damage, microthrombosis, and inflammation.

The presence of isoforms of β-glucosidase has been reported in some grasses such as sorghum, rice and maize. This work aims to extract and characterize isoform II in β-glucosidase from S. edule. A crude extract was prepared without buffer solution and adjusted to pH 4.6. Contaminating proteins were precipitated at 4 °C for 24 h. The supernatant was purified by chromatography on carboxymethyl cellulose (CMC) column, molecular exclusion on Sephacryl S-200HR, and exchange anionic on QFF column. Electrophoretic analyzes revealed a purified enzyme with aggregating molecular complex on SDS-PAGE, Native-PAGE, and AU-PAGE. Twelve peptides fragments were identified by nano liquid chromatography-tandem mass spectrometry (nano LC-ESI-MS/MS), which presented as 61% identical to Cucurbita moschata β-glucosidase and 55.74% identical to β-glucosidase from Cucumis sativus, another Cucurbitaceous member. The relative masses which contained 39% hydrophobic amino acids ranged from 982.49 to 2,781.26. The enzyme showed a specificity to β-d-glucose with a Km of 4.59 mM, a Vmax value of 104.3 μM∙min−1 and a kcat of 10,087 μM∙min−1 using p-nitrophenyl-β-D-glucopyranoside. The presence of molecular aggregates can be attributed to non-polar amino acids. This property is not mediated by a β-glucosidase aggregating factor (BGAF) as in grasses (maize and sorghum). The role of these aggregates is discussed.

En el tratamiento del cáncer de mama, además de la agresión quirúrgica, en ocasiones mutilante, seguida o precedida por las molestias inherentes a los tratamientos oncoespecíficos, a veces persisten "heridas", que aunque invisibles, no siempre cierran totalmente, y afectan durante mucho tiempo, o toda la vida, a un grupo importante de pacientes y familiares cercanos. El proyecto "Alas por la vida" propone nuevas alternativas en el tratamiento de la mujer con cáncer de mama, que puedan prepararla para una nueva etapa, y vivir con el estatus de enferma crónica, que no refleje invalidez en el desempeño de sus funciones, que alcance la recuperación de su equilibrio biopsicosocial, y, consecuentemente, el disfrute de una adecuada calidad de vida. Mediante intercambios entre sobrevivientes de la enfermedad, familiares y profesionales, charlas científicas, sesiones de preguntas y respuestas, reflexiones de operadas en su lucha contra el cáncer de mama y también de sus esposos, así como con actividades socioculturales, etc., se han logrado resultados muy positivos por este grupo, lo que se refleja en encuestas realizadas a tal efecto. El Grupo de Apoyo a Pacientes Mastectomizadas "Alas por la vida", ha resultado ser un instrumento muy útil para elevar la autoestima y mejorar la calidad de vida de las sobrevivientes, que a la vez ha fortalecido y humanizado nuestra lucha contra el cáncer de mama, y se han aglutinando crecientemente más seguidores en esta noble causa, por lo que recomendamos se organicen proyectos similares en todas las provincias del país.In the treatment of beast cancer besides the surgical aggression occasionally mutilating followed or precedes by the molecules inherent to specific oncologic treatments, sometimes the "wounds" persist that although invisibles, not always are totally closed involving for much time or for life to a significant group of patients and close relatives.The project "Alas por la Vida" proposes new alternatives in the treatment of a woman presenting with breast cancer that may to prepare them for a new stage and to live the chronic diseased status without reflecting disability in the performance of its activities, to achieve the recovery of its bio-psychosocial balance and consequently the enjoyment of an appropriate quality of life. By means of exchanges among survivors of this disease, relatives and professionals, scientific talks, questions and answers sessions, reflections of the operated on patients and their husbands in its fight against the breast cancer, as well as with sociocultural activities, etc, results have been obtained to that end.The "Alas por la vida" support group of women underwent mastectomy has been a very useful tool to rise the self-esteem and to improve the quality of life of the survivors strengthening and humanizing our fight against the breast cancer and more and more followers of this noble cause, thus, authors recommended the organization of projects similar in all the provinces of our country.

El Asma Bronquial es una enfermedad crónica con herencia multifactorial, que constituye un problema de salud en todo el mundo, con una tendencia a incrementar su morbimortalidad. Con el objetivo de proponer una estrategia de prevención para esta enfermedad se realizó una investigación epidemiológica, analítica, y transversal (sobre gemelos y Asma Bronquial) incluido como parte del programa de desarrollo de la Genética Médica en Cuba en el municipio de Pinar del Río, provincia Pinar del Río (Cuba). Esta permitió hacer una caracterización clínica-epidemiológica y genealógica de la enfermedad en gemelos con al menos, un miembro afecto e identificar que los factores genéticos contribuyen en un 72%, al origen del Asma Bronquial en este medio, determinado por los estudios de concordancia y cálculo de su heredabilidad, teniendo en cuenta que la mayoría de los gemelos comparten el mismo ambiente. En el contexto de la investigación fue elaborada y propuesta una Estrategia de Salud dirigido a la prevención y mejora de la calidad de vida de las personas que padecen Asma Bronquial, contando para ello con los recursos que aporta el Sistema de Salud en Cuba y el apoyo de la sociedad organizada.Bronchial Asthma is a chronic disease with multifactorial inheritance that constitutes a health problem all over the world, having an increasing morbidity and mortality rate. Aimed at suggesting a strategy for the prevention of this disease an epidemiological, analytical and cross-sectional research (about bronchial asthma and twins) was conducted and included as a part of the program for the development of Medical Genetics in Cuba, Pinar del Rio municipality (Cuba). This research allowed making a clinical-epidemiological and genealogical characterization of this disease, with at least one member affected as well as to identify that genetic factors contribute with 72% of the disease origin in this environment, determining it by means of the studies of concordance and inheritance; taking into consideration that the majority of the twins share the same environment. During the research a Health Strategy was created aimed at preventing and improving the quality of life of people who suffer from Bronchial Asthma, supported on the resources of the Cuban Health System and the organization of the society.

El embarazo postérmino es una entidad obstétrica muy discutida en la literatura médica debido a los diferentes criterios empleados con relación al diagnóstico, control prenatal, conducta a tomar y manejo intraparto. Con el objetivo de determinar el comportamiento de la inducción del parto en el embarazo postérmino, se realizó un estudio de casos y controles en el Hospital General Docente "Abel Santamaría" de Pinar del Río, en el trienio 2005-2007. El universo estuvo constituido por todos los nacimientos de esa institución hospitalaria, el grupo estudio por las embarazadas con 42 semanas de gestación con una labor de parto inducida (n=239) y un grupo control por las primeras 10 gestantes de cada mes con una labor de parto espontánea y edad gestacional de 37-41 semanas, con un feto vivo y con presentación de vértice (n=360). Se estudió: edad materna, paridad anterior, modo de terminación del parto, puntaje de Apgar del recién nacido, índice de Bishop, morbilidad materna y neonatal. Se utilizó frecuencia absoluta, porcentaje, Ji Cuadrado y Odds ratio al 95 % de certeza. Resultaron factores de riesgo de embarazo postérmino con labor inducida: la adolescencia (OR=5), la multiparidad (OR=7.5) y el índice de Bishop Post-term pregnancy is a controversial obstetric entity in medical literature due to the different criteria used regarding to its diagnosis, prenatal control, treatment to be followed and intra-labor management. Aimed at determining the behavior of the induction of labor in post-term pregnancy a case and control study was conducted at "Abel Santamaria Cuadrado" University Hospital, Pinar del Rio, during a three-year period (2005-2007). The universe was comprised of all the births occurring in the institution, women surpassing 42 weeks of pregnancy and inducing labor (n=239) and a control group for the first 10 pregnant women of each month with spontaneous labor and gestational age of 37-41 weeks, live fetus and with apex presentation (n=360). Maternal age, previous parity, ending of labor, Apgar score of the newborn, Bishop rate, maternal and neonatal mortality were the variables studied. Absolute frequency, percentage method, chi square test and Odss ratio to 95% of certainty were used. Post-term pregnancy with inducing labor had as risk factors: adolescence (OR=5), multiparity (OR=7.5) and the Bishop rate < 7 points (OR =6.6); prevailing cesarean section in post-term pregnancy, newborns presented a high incidence of low Apgar scores (p

Con el objetivo de identificar los factores epidemiológicos relacionados con la placenta previa se realizó un estudio retrospectivo, transversal y analítico (casos y controles) en el Hospital General Universitario "Abel Santamaría Cuadrado", en el período comprendido abril 2006 - 2007. El grupo estudio lo conformaron 19 pacientes con el diagnóstico de placenta previa y el grupo control 60 gestantes excluidas de este diagnóstico. Se estudiaron variables de la madre, del embarazo, nacimiento y neonato. Se utilizó el método empírico de medición usando la estadística descriptiva y deductiva. Se empleó la medición porcentual y Ji cuadrado (X²), con un nivel de significación de p < 0,05; además la prueba Odds ratio (OR) con un intervalo de confianza del 95% (IC 95%). La edad materna más frecuente de asociación con la placenta previa se encontró en el grupo de edades de 25 a 34 años. Los principales factores epidemiológicos a su vez catalogados como riesgos fueron: la procedencia urbana (OR=1,7), la desnutrición por defecto (OR=6,61) y por exceso (OR=3,93), la multiparidad (OR=1,55), antecedentes de aborto (OR=5,08) y de cesárea anterior (OR=3,21), así como la operación cesárea como modo de terminación del embarazo (OR=13,67**). Fue un terreno propicio para la morbilidad materno-neonatal.Aimed at identifying the epidemiological factors associated with placenta previa a retrospective, cross-sectional and analytical study (cases and controls) was conducted at "Abel Santamaria Cuadrado" University Hospital during April 2006-2007. The study group was comprised of 19 pregnant patients with placenta previa and 60 belonging to control group that were not included in the diagnosis. Variables of mothers, pregnancy, birth and newborn were studied. The empirical method of measurement using the descriptive and inferential statistics was applied; as well as percentage, chi square test (X²), a level of significance p

Con el objetivo de contribuir al mejor conocimiento del oligoamnios en nuestro medio, se realizó un estudio epidemiológico, observacional y analítico (casos y controles) en gestantes con oligoamnios en el Hospital General Universitario "Abel Santamaría Cuadrado" de Pinar del Río, en el período comprendido enero - diciembre de 2006. Se estudió un grupo de gestantes con oligoamnios por ultrasonido y un grupo control de gestantes sin esa entidad. Se estudiaron variables de la madre, del embarazo, nacimiento y neonato. Se utilizaron como métodos el Porcentaje, Media, Desviación estándar, Ji cuadrado, Odds Ratio con un intervalo de confianza del 95% (IC 95%) y el Riesgo Atribuible Porcentual (RAP). Los principales factores de riesgo fueron: el bajo peso al inicio de la gravidez (OR=16,7 y RAP=58,9%), el crecimiento intrauterino retardado (OR=5,5 y RAP=49,9%) y el embarazo prolongado (OR=3,8 y RAP=43,9); la insuficiente ganancia de peso y la senectud placentaria sólo estuvieron presentes en el grupo de control. El oligoamnios, a su vez, fue el factor de riesgo de labor inducida de parto y de puntaje de Apgar< 7 puntos a los 5 minutos de nacido. El 47,2% de las gestantes terminaron la gestación por cesárea primitiva y el sufrimiento fetal agudo fue la principal causa. El CIUR estuvo involucrado en gran medida con el oligoamnios y la asfixia severa recuperada fue dos veces más frecuente en las gestantes con ILA < 2,5 percentil; la no recuperada resultó ser causa de mortalidad neonatal en nuestra serie. No hubo muerte materna.Aimed at contributing to the better knowledge of Oligoamnios in obstetric context an epidemiological, analytical and observation study (cases and control) in pregnant women presenting oligoamnios at "Abel Santamaría Cuadrado" University Hospital in Pinar del Rio was conducted during January-December 2006. A group of pregnant women with oligoamnios (ultrasonic scanning) and a control group without this entity were included in the study. Variables of mothers, pregnancy, birth and newborn were studied. Percentage, mean, standard deviation, chi-square test, odds ratio with confidence interval (CI- 95%) and the attributable risk percent (ARP) were used as statistical methods. The main risk factors were: low-weight at early pregnancy (OR= 16,7 and ARP =58,9%), retarded intrauterine growth (OR= 5,5 and ARP= 49,9%) and the prolonged pregnancy (OR= 3,8 and ARP= 43,9); being only present in the control group the insufficient weight-gaining and the placental aging. The Oligoamnios was, at the same time, a risk factor for induced labor and to the Apgar score < 7 at 5 minutes birth. The 47, 2% of the pregnants ended the pregnancy with a primitive cesarean section and acute fetal distress was the main cause. The retarded intrauterine growth was in large measure associated with oligoamnios and recovered severe asphyxia was twice more frequent in pregnants with ILA < 2, 5 percentile; no-recovered asphyxia was the cause of newborn-death in this series, having no maternal death.

Se presentan 15 enfermos con bullas enfisematosas gigantes, tratados mediante lobectomía reglada en el Hospital Universitario "Comandante Manuel Fajardo", en el período de 1995 a 2000; todos estos pacientes se abordaron mediante incisiones axilares y en el 100 % eran del sexo masculino fumadores de 2 cajetillas de cigarros diarios. La mortalidad quirúrgica fue del 6,6 % a causa de que uno de los pacientes falleció por trombolismo pulmonar. En los 14 enfermos restantes se valoraron las pruebas funcionales respiratorias y se observó un cambio del volumen espiratorio forzado de disminución del volumen residual. En la gasometría arterial, la presión de oxígeno (PO2) aumentó en todos los enfermos hasta valores entre 80 y 85 lo que les permitió incorporarse a su vida laboral activa15 patients with giant emphysematous bullas treated by ruled lobectomy at Comandante Manuel Fajardo Teaching Hospital, from 1995 to 2000, were presented. All these patients were approached by axillary incisions. 100 % were males who smoked 2 packages of cigarettes daily. Surgical mortality was 6.6 % due to the fact that one of the patients died from pulmonary trombolism. In the other 14 patients the functional respiratory tests were made and it was observed a change of the forced expiratory volume in the reduction of the residual volume. In the arterial gasometry, the oxygen pressure (02P) increased in all patients, reaching values between 80 and 85, which allowed them to incorporate to their active working life

Se reportan las complicaciones de 72 enfermos con resecciones pulmonares, durante el período de 1995 a 1999 en el Hospital Clinicoquirúrgico "Comandante Manuel Fajardo". El 61,1 % fue por resecciones regladas (lobectomías y neumonectomías) y el resto atípicas. La mortalidad quirúrgica fue de 4,1 % y la morbilidad del 11,1 %. Las complicaciones más frecuentes fueron la neumonía y la sepsis de la herida, observada en el 2,7 %. La fístula bronquial se presentó en un enfermo (1,3 %).The complications of 72 patients with pulmonary resections performed at "Comandante Manuel Fajardo" Clinical and Surgical Hospital from 1995 to 1999 are reported. 61.1 % of the complications were due to segmental resections (lobectomies and neuronectomies) and the rest were atypical. Surgical mortality was 4.1 % and morbidity 11.1 %. The most frequent complications were pneumonia and wound sepsis, which were observed in 2.7 %. A patient had bronchial fistula (1.3 %).

Se presenta la estrategia ante el cáncer de esófago irresecable y se exponen los resultados en 24 enfermos con mal estado general, en los que se utilizó prótesis transtumorales, combinada en 8 casos previamente con infiltración de alcohol absoluto al tumor, sin presentar mortalidad quirúrgica y una supervivencia del 75 % a los 6 meses y del 33,3 % al año. Todos los enfermos tuvieron control endoscópico previo, utilizando el método de tracción en la colocación de la prótesisThe authors present the strategy used in the non-resectable esophagus cancer and show the results obtained in 24 patients with a poor general state, among whom transtumor prostheses were utilized. These prostheses were previously combined with infiltration of absolute alcohol to the tumor in 8 cases. There was no surgical mortality and it was attained a survival of 75 % at 6 months and of 33.3 % at a year. All patients had a previous endoscopic control. Prostheses were placed by using the traction method

Se presenta un enfermo de 63 años de edad, con un tumor voluminoso en cara anterior del cuello, que se moviliza a la deglución. La biopsia aspirativa con aguja fina (BAAF) informó tejido tiroideo. Se comprueba con la exéresis del tumor el diagnóstico de quiste branquial en una localización inusualA 63-year-old patient with a voluminous tumor in the anterior side of the neck that mobilizes on deglutition is presented. Thyroid tissue was found on performing fine needle aspiration biopsy (FNAB). The diagnosis of branchial cyst in an unsual localization was proved with the exeresis of the tumor

Se reporta una paciente de 24 años de edad, con antecedentes de apendicectomía, que meses después presentó cuadros de fiebre que desaparecen con diarreas profusas. El diagnóstico radiológico y quirúrgico confirmó la presencia de una fístula colónica interna con la confirmación de un pseudocolon derecho a expensas del parietocólico derecho. El tratamiento curativo incluyó la resección del segmento de colon afectado con drenaje y curetaje del parietocólicoA 24-year old patient with history of appendectomy that some months later had episodes of fever that disappear with profuse diarrheas is presented. The radiologic and surgical diagnosis proved the presence of a colonic internal fistula with the confirmation of a right pseudocolon at the expense of the right parietocolic. The curative treatment included the resection of the affected colon segment with drainage and curettage of the right parietocolic

INTRODUCCIÓN. La displasia mamaria es un problema de salud de gran repercusión social, por el estrés y la ansiedad que suelen acompañarla. El presente trabajo tuvo el objetivo de valorar diferentes variantes de conducta ante esta afección. MÉTODOS. Se realizó un estudio retrospectivo-prospectivo con 3668 pacientes diagnosticadas de displasia mamaria, y atendidas por esta razón entre enero de 1991 y diciembre de 2004 en el Hospital Universitario Comandante «Manuel Fajardo». RESULTADOS. La incidencia de displasia mamaria (enfermedad fibroquística) en la consulta de patología mamaria fue del 50 %, seguida en frecuencia por el fibroadenoma y las enfermedades inflamatorias. Se realizó el estudio en dos etapas: una con carácter retrospectivo (1991-1996) y otra con carácter prospectivo (1997-2004). La evolución de los casos que solo recibieron información fue similar a la de los pacientes que fueron sometidos a otros esquemas de tratamiento médico, en ambas etapas. Se necesitó exéresis quirúrgica en el 16,21 % y 13,42 % de los pacientes, respectivamente, a causa de dudas en relación con un carcinoma. CONCLUSIONES. La información médica es una opción que puede utilizarse en más del 70 % de las mujeres que presentan displasia mamaria (enfermedad fibroquística). Tiene la ventaja de que los resultados son más duraderos que los del tratamiento médico, y de que disminuye el consumo innecesario de medicamentos. El tratamiento quirúrgico de la enfermedad fibroquística está solo justificado ante la duda de cáncer y en lesiones que no se modifican ni duelen durante el ciclo menstrual, sobre todo en el caso de mujeres mayores de 35 años.INTRODUCTION. Breast dysplasia is a health problem of great social impact due to the stress and anxiety accompanying it. The present paper was aimed at assessing different variants of behavior before this affection. METHODS. A retrospective prospective study was conducted among 3 688 patients that were diagnosed breast dysplasia and received attention from January 1991 to December 2004 in «Comandante Manuel Fajardo» Teaching Hospital. RESULTS. The incidence of breast dysplasia (fibrocystic disease) at the breast pathology office was 50 %, followed in frequency by fibroadenoma and inflammatory diseases. A two-stage study was undertaken: one with retrospective character (1991-1996) and the other with prospective character (1997-2004). The evolution of the cases that received only information was similar to that of those that underwent other medical treatment schemes, in both stages. Surgical exeresis was necessary in 16.21 % and 13.42 % of the patients, respectively, due to suspicion of carcinoma. CONCLUSIONS. Medical information is an option that may be used in more than 70 % of females with breast dysplasia (fibrocystic disease). Some of its advantages are that the results last more than those of medical treatment and that it reduces the unnecessary administration of drugs. The surgical treatment of the fibrocystic disease is only justified when cancer is suspected and in lesions that neither modify nor hurt during the menstrual cycle, mainly in females over 35.

INTRODUCCIÓN. El neumotórax espontáneo simple es causado, en general, por la rotura de una pequeña zona debilitada del pulmón. Un neumotórax recidivante puede causar una incapacidad considerable. MÉTODOS. Se realizó un estudio descriptivo, prospectivo, de corte transversal de los pacientes con neumotórax persistente y recidivante, atendidos en el Hospital Universitario «Comandante Manuel Fajardo» en el período de 1988 a 2006. Se analizaron las causas del neumotórax y los resultados de su tratamiento. El universo de estudio fueron todos los pacientes con diagnóstico de neumotórax (225 pacientes), entre los cuales se seleccionó a los diagnosticados de neumotórax persistente o recidivante (42 en total). Todos los pacientes fueron atendidos siguiendo un algoritmo de trabajo del servicio de cirugía del hospital. RESULTADOS. Las bullas fueron la causa fundamental en el neumotórax recidivante y las vesículas subpleurales, en los persistentes. En los neumotórax persistentes se mantuvo la sonda de aspiración hasta el quinto día en el 71 % de los casos, hasta 5 a 7 días en el 23 % y por más de 7 días en el 6 %. Se utilizó la vía axilar para la incisión y se realizó resección atípica o reglada con pleurectomía parietal o abrasión, que tuvo un 100 % de efectividad. La mortalidad quirúrgica fue nula. CONCLUSIONES. Los cuidados de la sonda de pleurotomía y la aspiración continua controlada son pilares en el tratamiento primario del neumotórax. Después de 5 días sin lograr la reexpansión pulmonar y si existe un segundo neumotórax, debe siempre valorarse el tratamiento definitivo por toracotomía. Debe considerarse la pleurectomía parietal como el proceder de elección en los pacientes con reserva cardiorrespiratoria adecuada. Un buen sistema de aspiración de drenaje hace que no sea necesaria una segunda intervención y disminuye las posibilidades de complicacionesINTRODUCTION. The simple spontaneous pneumothorax is generally caused by the rupture of a small weakened zone of the lung. A recurrent pneumothorax may cause considerable disability. METHODS. A descriptive, prospective and cross-sectional study was conducted among the patients with persistent and recurrent pneumothorax that received attention at "Comandante Manuel Fajardo" University Hospital from 1998 to 2006. The causes of the pneumothorax and the results of its treatment were analyzed. The study group was composed of all the patients with pneumothorax diagnosis (225 patients), of whom those diagnosed with persistent or recurrent pneumothorax (42 in all) were selected. All the patients were attended by following a working algorithm of surgery service of the hospital. RESULTS. The bullae were the main cause of the recurrent pneumothorax, and the subpleural vesicles of the persistent. In the persistent pneumothorax, the aspiration probe was maintained until the fifth day in 71 % of the cases, from 5 to 7 in 23 %, and for more than 7 days in 6 %. The axillary route was used for the incision, and atypical or regulated resection was performed with parietal pleurotomy or abrasion, which had 100 % of effectivity. No surgical mortality was reported. CONCLUSIONS. The care of the pleurotomy catheter and the continual controlled aspiration are milestones in the primary treatment of pneumothorax. After 5 days without attaining the pulmonary reexpansion, and if there is a second pneumothorax, the definitive treatment by thoracotomy should always be assessed. Parietal pleurotomy should be considered as an elective procedure in the patients with an adequate respiratory reserve. A good drainage aspiration system prevents a second intervention and reduces the possibilities of complications

En 1945, Foote y Stewart plantearon que “el antecedente más frecuente de cáncer en un seno es haber tenido una neoplasia en el seno contrario”. Se realizó un estudio sobre los casos de cáncer de mama bilateral atendidos en nuestro servicio entre 1982 y 2003. Métodos: El universo de nuestro trabajo está compuesto por 25 pacientes que fueron atendidas en los últimos 20 años por cáncer de mama bilateral, la mayoría de ellos metacrónicos (21 casos). En cada caso se analizó edad, etapas clínicas al momento del diagnóstico, tratamiento utilizado, tipo histológico y evolución, entre otras variables. Resultados: Se observó la mayor incidencia de esta enfermedad en la 5ta. y 6ta. décadas de la vida, con predominio de los tumores en etapa II. El tipo de operación más realizado fue la mastectomía radical modificada de Patey y prevalecieron las técnicas más conservadores en la segunda operación. Siete de las pacientes fallecieron por la enfermedad. Conclusiones: El pronóstico de las mujeres con cáncer de mama bilateral suele ser favorable y depende de la etapa de desarrollo de éste al momento del diagnóstico. El tratamiento del segundo primario fue más conservador que el primero. El seguimiento estricto y el uso de la ingeniería genética son elementos fundamentales para el diagnóstico precozIn 1945, Foote and Stewart said: “the most frequent antecedent of cancer in a breast is having had a neoplasia in the other breast” A study of the cases of bilateral breast cancer seen in our service between 1982 and 2003 was conducted. Methods: The universe of our work was composed of 25 patients attended in the last 20 years due to bilateral breast cancer. Most of them were metachronic (21 cases). Age, clinical stages at the time of diagnosis, treatment used, histological type and evolution, among other variables, were analyzed. Results: the highest incidence of this disease was observed in the 5th and 6th decades of life, with predominance of stage II tumors. Patev's modified radical mastectomy was the most common operation. The most conservative techniques prevailed in the second operation. Seven of the patients died as a result of the disease. Conclusions: the prognosis of women with bilateral breast cancer is usually favorable and it depends on its development stage at the time of the diagnosis. The treatment of the second was more conservative than the first one. The strict follow-up and the use of genetic engineering are fundamental elements for the early diagnosis

Con el objetivo de determinar la conducta ante el neumotórax espontáneo, se realizó un estudio descriptivo, prospectivo, de corte transversal, en 125 pacientes con diagnóstico de neumotórax espontáneo, que fueron atendidos en el Hospital Docente “Comandante Manuel Fajardo” en el período comprendido entre enero de 1988 y julio de 2003. El 62,4 % de los casos estudiados correspondió a neumotórax primario y los restantes a neumotórax secundario. Predominaron las edades tempranas de la vida y el sexo masculino, este último en una relación de 14 a 1. Los síntomas más reportados fueron dolor, disnea y tos, y el 88,8 % de los pacientes eran fumadores. La pleurotomía fue el tratamiento definitivo en el 65,8 % de los pacientes y eficaz en el 85,6 %. Fue necesaria la toracotomía en 29,4 % de los casos, por la presencia de neumotórax persistente, recidivante y bullas. No tuvimos mortalidad quirúrgica. Concluimos que la conducta ante el neumotórax depende de la magnitud, repercusión clínica, etiología, necesidad de evitar la recidiva y la evaluación del riesgo quirúrgicoIn order to determine the conduct to be followed with the spontaneous pneumothorax, a descriptive, prospective, cross-sectional study was undertaken among 125 patients with diagnosis of spontaneous pneumothorax that received attention at “Comandante Manuel Fajardo” Teaching Hospital from January 1998 to July 2003. 62.4 % of the cases studied corresponded to primary pneumothorax and the rest to secondary pneumothorax. There was predominance of early ages and of males. The latter at a ratio of 14:1. The most reported symptoms were pain, dyspnea, and cough. 88,8 % of the patients were smokers. Pleurotomy was the definitive treatment in 65.8 % of the patients and it was efficient in 85.6 %. Thoracotomy was necessary in 29.4 % of the cases due to the presence of persistent, recidivant pneumothorax and bullae. There was no surgical mortality. We concluded that the conduct to be followed with pneumothorax depends on the magnitude, clinical repercussion, etiology, need to prevent relapse and the evaluation of the surgical risk