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2. Maternal human papillomavirus infections at mid-pregnancy and delivery in a Scandinavian mother–child cohort study

Author

Værnesbranden, Magdalena R., Wiik, Johanna, Sjøborg, Katrine, Staff, Anne Cathrine, Carlsen, Karin C. Lødrup, Haugen, Guttorm, Hedlin, Gunilla, Hilde, Katarina, Nordlund, Björn, Nystrand, Camilla F., Rangberg, Anbjørg, Rehbinder, Eva Maria, Rudi, Knut, Rueegg, Corina Silvia, Sandberg, Yvonne, Sjelmo, Sigrid, Skjerven, Håvard O., Söderhäll, Cilla, Vettukattil, Riyas, and Jonassen, Christine M.

Published
2021
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3. DNA methylation in childhood asthma: an epigenome-wide meta-analysis

Author

Xu, Cheng-Jian, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gruzieva, Olena, Gehring, Ulrike, Mason, Dan, Chatzi, Leda, Basterrechea, Mikel, Llop, Sabrina, Torrent, Maties, Forastiere, Francesco, Fantini, Maria Pia, Carlsen, Karin C Lødrup, Haahtela, Tari, Morin, Andréanne, Kerkhof, Marjan, Merid, Simon Kebede, van Rijkom, Bianca, Jankipersadsing, Soesma A, Bonder, Marc Jan, Ballereau, Stephane, Vermeulen, Cornelis J, Aguirre-Gamboa, Raul, de Jongste, Johan C, Smit, Henriette A, Kumar, Ashish, Pershagen, Göran, Guerra, Stefano, Garcia-Aymerich, Judith, Greco, Dario, Reinius, Lovisa, McEachan, Rosemary R C, Azad, Raf, Hovland, Vegard, Mowinckel, Petter, Alenius, Harri, Fyhrquist, Nanna, Lemonnier, Nathanaël, Pellet, Johann, Auffray, Charles, van der Vlies, Pieter, van Diemen, Cleo C, Li, Yang, Wijmenga, Cisca, Netea, Mihai G, Moffatt, Miriam F, Cookson, William O C M, Anto, Josep M, Bousquet, Jean, Laatikainen, Tiina, Laprise, Catherine, Carlsen, Kai-Håkon, Gori, Davide, Porta, Daniela, Iñiguez, Carmen, Bilbao, Jose Ramon, Kogevinas, Manolis, Wright, John, Brunekreef, Bert, Kere, Juha, Nawijn, Martijn C, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, and Koppelman, Gerard H

Published
2018
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6. Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Author

Bousquet, Jean, Melén, Erik, Haahtela, Tari, Koppelman, Gerard, Togias, Alkis, Valenta, Rudolf, Akdis, Cezmi, Czarlewski, Wienczyslawa, Rothenberg, Marc, Valiulis, Arunas, Wickman, Magnus, Vichyanond, Pakit, Moniuszko, Marcin, Ėmužytė, Regina, Bush, Andrew, Chu, Derek K, Viegi, Giovanni, Wallace, Dana, Durham, Stephen, Wang, De Yun, Vandenplas, O., Just, Jocelyne, Carlsen, Karin C. Lodrup, Passalacqua, Giovanni, Williams, Siân, Linnemann, Désirée Larenas, Loureiro, Cláudia Chaves, Sagara, Hironori, Worm, Margitta, Yiallouros, Panayiotis, Yusuf, Osman, Zaitoun, Fares, Bonini, Matteo, Hrubiško, Martin, Cingi, C., Dykewicz, Mark, Zernotti, Mario, Calderon, Moises, Halpin, David M.G., Zidarn, Mihaela, Patella, Vincenzo, Sheikh, Aziz, Zuberbier, Jaron, Papadopoulos, Nikolaos, Louis, Renaud, Suppli Ulrik, Charlotte, Fonseca, João P., Zuberbier, Torsten, Anto, M. J., Costa, Elisio, Eiwegger, Thomas, Bosnic-Anticevich, Sinthia, Cruz, Alvaro, Sousa, Jaime Correia de, Louis-Philippe, Boulet, Erhola, Marina, Cardona, Victoria, Carr, Warner, Gemicioglu, Bilun, Pawankar, Ruby, Fokkens, Wytske, Calvo, Mário, Garcia-Aymerich, J., Mäkelä, Mika J., Hofmann, Maja Ann, Klimek, Ludger, Makris, Michael, Mohamed Sayed, Zeinab, Maurer, Marcus, D'Amato, G., Momas, Isabelle, Siroux, Valérie, Almeida, Mário Morais, Corrigan, Chris, Mullol, Joaquim, Montefort, Stephen, Jutel, Marek, Pham Thi, Nhan, Hossny, Elham, Akdis, Mubeccel, Pfaar, Oliver, Ventura, Maria Teresa, Regateiro, Frederico S., Bindslev-Jensen, Carsten, Ring, Johannes, Bustamante, Mariona, Pinto, Bernardo Sousa, Kaidashev, Igor, Guerra, Stefano, Standl, Marie, Sunyer, J., Keil, Thomas, Barata, Luís Taborda, Camargos, Paulo, Weiss, Scott, Naclerio, Robert, Yorgancıoglu, Arzu, Zhang, Luo, Nadeau, Kari, Abdul Latiff, Amir, Aberer, Werner, Heinrich, Joachim, Sisul, Juan, Nunes, Elizabete, Plavec, Davor, Agache, Ioana, Al-Ahmad, Mona, Serpa, Faradiba, Alobid, Isam, Kalayci, Omer, Giacco, S. Del, Fiocchi, Alessandro, Ansotegui Zubeldia, Ignacio Javier, Custovic, Adnan, Martins, Pedro Carreiro, Rouadi, Philip, Arshad, Syed Hasan, Asayag, Estrella, Bárbara, Cristina, Abdullah, Baharudin, Tomazic, Peter Valentin, Popov, T. A., Sayah, Zineb, Lkhagvaa, Battur, Nyembue Tshipukane , Dieudonne, Thomas, Mike, Bennoor, Kazi Saifuddin, Fyhrquist, Nanna Theresia, Irani, Carla, Berghea, Elena Camelia, De Blay, Frédéric, Toppila-Salmi, Sanna Katriina, Bergmann, Karl-Christian, Bernstein, D., Bewick, M., Casale, Thomas, Scheire, Sophie, Bumbacea, Roxana Silvia, Cepeda Sarabia, Alfonso, Puggioni, Francesca, Chandrasekharan, Ramanathan, Ohta, Ken, Okubo, Kimihiro, Charpin, Denis, Gomez, R Maximiliano, Chen, Y. Z., O'Hehir, Robyn, Cherrez Ojeda, Ivan, Bedbrook, Anna, To, Teresa, Devillier, Philippe, Schmid-Grendelmeier, Peter, Didier, Alain, Repka-Ramirez, María Susana, Teixeira, Maria Do Céu, Ispayeva, Zhanat, Dokic, Dejan, Quirce, Santiago, Douagui , Habib, Ivancevich, Juan Carlos, Gotua, Maia, Todo-Bom, Ana, Blain, Hubert, Guzman, Maria Antonieta, Kalyoncu, Ali Fuat, Hagemann, Jan, Buhl, Roland, Hamamah, Samir, Caraballo, Luis, Jares, Edgardo, Chivato, Tomás, Jartti, Tuomas, Jassem, Ewa, Christoff, George, Julge, Kalev, Ogulur, Ismail, Kardas, Przemyslaw, Doulaptsi, Maria, Kirenga, Bruce, Helga, Kraxner, Kull, Inger, Kulus, Marek, Daniel, Aguilar, Shamji, Mohamed, Kuna, Piotr, Nadif, Rachel, La Grutta, Stefania, Brightling, Chris, Samoliński, Bolesław, Lau, Susanne, Cordeiro, Carlos Manuel Da Silva Robalo, Solé, Dirceu, Le Thi Tuyet, Lan, Recto, Marysia, Ouedraogo, Solange, Halken, Susanne, Levin, Michael, Lipworth, Brian, Lourenço, Olga, Mahboub, Bassam, Niedoszytko, Marek, Sastre, Joaquin, Martinez‐Infante, E., Kupczyk, Maciej, Torres, María Jose, Matricardi, Paolo Maria, Cecchi, Lorenzo, Celedón, Juan C, Miculinic, Neven, Roche, Nicolas, Migueres, Nicolas, Brussino, Luisa, Florin, Mihaltan, Olze, Heidi, Savouré, Marine, Nekam, Kristof, Pali, Isabella, Okamoto, Yoshitaka, Palomares, O., Lemonnier, Nathanaël, Palosuo, Kati, Soto-Martinez, Manuel, Panaitescu, Carmen, Kvedarienė, Violeta, Panzner, P., Braido, Fulvio, Tsiligianni, Ioanna, Rodriguez-Gonzalez, Monica, Scichilone, Nicola, Canonica, Giogio Walter, Romantowski, Jan, Urrutia-Pereira, Marilyn, Filho, Nelson Augusto Rosario, Ollert, Markus W., Rottem, Menachem, Chkhartishvili, Ekaterine, Sova, Milan, Valovirta, Erkka, Mohammad, Yousser, Sperl, Annette, Spranger, Otto, Neffen, Hugo, Stelmach, Rafael, Burte, Emilie, Valentin Rostan, Marylin, Park, Hae-Sim, Van Ganse, Eric, Van Hage, Marianne, Pitsios, Constantinos, Vasankari, Tuula, and uBibliorum

Subjects
IL-33, Multimorbidity, Asthma, Toll-like receptors, Rhinitis
Abstract

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.

Published
2023

8. Urinary biomarkers for phthalates associated with asthma in Norwegian children

Author

Bertelsen, Randi J., Carlsen, Karin C. Lodrup, Calafat, Antonia M., Hoppin, Jane A., Haland, Geir, Mowinckel, Petter, Carlsen, Kai-Hakon, and Lovik, Martinus

Subjects
Asthma in children -- Risk factors -- Demographic aspects -- Research, Phthalates -- Health aspects, Biological markers -- Usage -- Health aspects, Environmental issues, Health
Abstract

Phthalates are widely used as plasticizers in consumer products such as building materials, toys, food packaging, cosmetics, and medical devices (Schettler 2006). The length of the alkyl chains gives rise [...]

Published
2013

9. Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence

Author

Bousquet, Jean, Schunemann, Holger J., Togias, Akdis, Bachert, Claus, Erhola, Martina, Hellings, Peter W., Klimek, Ludger, Pfaar, Oliver, Wallace, Dana, Ansotegui, Ignacio, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl-Christian, Bewick, Mike, Bonniaud, Philippe, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Brozek, Jan, Brusselle, Guy, Calderon, Moises A., Canonica, Walter G., Caraballo, Luis, Cardona, Vicky, Casale, Thomas, Cecchi, Lorenzo, Chu, Derek K., Costa, Elisio M., Cruz, Alvaro A., Czarlewski, Wienczyslawa, D'Amato, Gennaro, Devillier, Philippe, Dykewicz, Mark, Ebisawa, Motohiro, Fauquert, Jean-Louis, Fokkens, Wytske J., Fonseca, Joao A., Fontaine, Jean-Francois, Gemicioglu, Bilun, van Wijk, Roy Gerth, Haahtela, Tari, Halken, Susanne, Ierodiakonou, Despo, Iinuma, Tomohisa, Ivancevich, Juan-Carlos, Jutel, Marek, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Tebbe, Jorg Kleine, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, La Grutta, Stefania, Larenas-Linemann, Desiree, Lau, Susanne, Laune, Daniel, Le, Lan, Lieberman, Philipp, Carlsen, Karin C. Lodrup, Lourenco, Olga, Marien, Gert, Carreiro-Martins, Pedro, Melen, Erik, Menditto, Enrica, Neffen, Hugo, Mercier, Gregoire, Mosgues, Ralph, Mullol, Joaquim, Muraro, Antonella, Namazova, Leyla, Novellino, Ettore, O'Hehir, Robyn, Okamoto, Yoshitaka, Ohta, Ken, Park, Hae Sim, Panzner, Petr, Passalacqua, Giovanni, Price, David, Roberts, Graham, Roche, Nicolas, Rolland, Christine, Rosario, Nelson, Ryan, Dermot, Samolinski, Boleslaw, Sanchez-Borges, Mario, Scadding, Glenis K., Shamji, Mohamed H., Sheikh, Aziz, Bom, Ana-Maria Todo, Toppila-Salmi, Sanna, Tsiligianni, Ioana, Valentin-Rostan, Marylin, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Waserman, Susan, Yorgancioglu, Arzu, Zuberbier, Torsten, Bousquet, Jean, Schunemann, Holger J., Togias, Akdis, Bachert, Claus, Erhola, Martina, Hellings, Peter W., Klimek, Ludger, Pfaar, Oliver, Wallace, Dana, Ansotegui, Ignacio, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl-Christian, Bewick, Mike, Bonniaud, Philippe, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Brozek, Jan, Brusselle, Guy, Calderon, Moises A., Canonica, Walter G., Caraballo, Luis, Cardona, Vicky, Casale, Thomas, Cecchi, Lorenzo, Chu, Derek K., Costa, Elisio M., Cruz, Alvaro A., Czarlewski, Wienczyslawa, D'Amato, Gennaro, Devillier, Philippe, Dykewicz, Mark, Ebisawa, Motohiro, Fauquert, Jean-Louis, Fokkens, Wytske J., Fonseca, Joao A., Fontaine, Jean-Francois, Gemicioglu, Bilun, van Wijk, Roy Gerth, Haahtela, Tari, Halken, Susanne, Ierodiakonou, Despo, Iinuma, Tomohisa, Ivancevich, Juan-Carlos, Jutel, Marek, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Tebbe, Jorg Kleine, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, La Grutta, Stefania, Larenas-Linemann, Desiree, Lau, Susanne, Laune, Daniel, Le, Lan, Lieberman, Philipp, Carlsen, Karin C. Lodrup, Lourenco, Olga, Marien, Gert, Carreiro-Martins, Pedro, Melen, Erik, Menditto, Enrica, Neffen, Hugo, Mercier, Gregoire, Mosgues, Ralph, Mullol, Joaquim, Muraro, Antonella, Namazova, Leyla, Novellino, Ettore, O'Hehir, Robyn, Okamoto, Yoshitaka, Ohta, Ken, Park, Hae Sim, Panzner, Petr, Passalacqua, Giovanni, Price, David, Roberts, Graham, Roche, Nicolas, Rolland, Christine, Rosario, Nelson, Ryan, Dermot, Samolinski, Boleslaw, Sanchez-Borges, Mario, Scadding, Glenis K., Shamji, Mohamed H., Sheikh, Aziz, Bom, Ana-Maria Todo, Toppila-Salmi, Sanna, Tsiligianni, Ioana, Valentin-Rostan, Marylin, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Waserman, Susan, Yorgancioglu, Arzu, and Zuberbier, Torsten

Abstract

The selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease and depends on many factors. Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines have considerably improved the treatment of allergic rhinitis. However, there is an increasing trend toward use of real-world evidence to inform clinical practice, especially because randomized controlled trials are often limited with regard to the applicability of results. The Contre les Maladies Chroniques pour un Vieillissement Actif (MACVIA) algorithm has proposed an allergic rhinitis treatment by a consensus group. This simple algorithm can be used to step up or step down allergic rhinitis treatment. Next-generation guidelines for the pharmacologic treatment of allergic rhinitis were developed by using existing GRADE-based guidelines for the disease, real-world evidence provided by mobile technology, and additive studies (allergen chamber studies) to refine the MACVIA algorithm.

Published
2020

10. Reduced lung function at birth and the risk of asthma at 10 years of age

Author

Haland, Geir, Carlsen, Karin C. Lodrup, Sandvik, Leiv, Devulapalli, Chandra Sekhar, Munthe-Kaas, Monica Cheng, Pettersen, Morten, and Carlsen, Kai-Hakon

Subjects
Asthma -- Risk factors, Asthma -- Health aspects, Asthma in children -- Risk factors, Asthma in children -- Health aspects
Abstract

A prospective birth cohort study of healthy infants is conducted in which the lung function is measured shortly after birth in order to assess whether reduced lung function shortly after birth predicts asthma 10 years later. The results have concluded that reduced lung function at birth is associated with an increased risk of asthma by 10 years of age.

Published
2006

11. ARIA pharmacy 2018 'Allergic rhinitis care pathways for community pharmacy'

Author

Yiallouros, Panayiotis K., Larenas‐Linnemann, Désirée E., Bosnic‐Anticevich, Sinthia, Costa, Elisio, Menditto, Enrica, Lourenço, Olga, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Buonaiuto, Roland, Chrystyn, Henry, Cvetkovski, Biljana, Capua, Stefania Di, Kritikos, Vicky, Mair, Alpana, Orlando, Valentina, Paulino, Ema, Salimäki, Johanna, Söderlund, Rojin, Tan, Rachel, Williams, Dennis M., Wroczynski, Piotr, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bedbrook, Anna, Bachert, Claus, Bewick, Mike, Bindslev‐Jensen, Carsten, Brozek, Jan L., Canonica, Giorgio Walter, Cardona, Victoria, Carr, Warner, Casale, Thomas B., Chavannes, Niels H., Sousa, Jaime Correia de, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Carlo, Giuseppe De, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., Gaga, Mina, El‐Gamal, Yehia, Fonseca, João, Fokkens, Wytske J., Guzmán, Maria Antonieta, Haahtela, Tari, Hellings, Peter W., Illario, Maddalena, Ivancevich, Juan Carlos, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Khaltaev, Nikolai, Keil, Thomas, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Laune, Daniel, Le, Lan T. T., Carlsen, Karin C. Lodrup, Mahboub, Bassam, Maier, Dieter, Malva, Joao, Manning, Patrick J., Morais‐Almeida, Mário, Mösges, Ralph, Mullol, Joaquim, Münter, Lars, Murray, Ruth, Naclerio, Robert, Namazova‐Baranova, Leyla, Nekam, Kristof, Nyembue, Tshipukane Dieudonné, Okubo, Kimi, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikolaos G., Park, Hae-Sim, Pawankar, Ruby, Pfaar, Oliver, Phillips, Jim, Plavec, Davor, Popov, Todor A., Potter, Paul C., Prokopakis, Emmanuel P., Roller‐Wirnsberger, Regina E., Rottem, Menachem, Ryan, Dermot, Samolinski, Bolesław, Sanchez‐Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan Carlos, Somekh, David, Stellato, Cristiana, To, Teresa, Todo‐Bom, Ana Maria, Tomazic, Peter Valentin, Toppila‐Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Valovirta, Errka, Ventura, Maria Teresa, Wagenmann, Martin, Wallace, Dana, Waserman, Susan, Wickman, Magnus, Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario E., Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, Bousquet, Jean, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Costa, Elisio [0000-0003-1158-1480], Kritikos, Vicky [0000-0003-3955-0002], Gaga, Mina [0000-0002-9949-6012], Papadopoulos, Nikolaos G. [0000-0002-4448-3468], and Prokopakis, Emmanuel P. [0000-0002-1208-1990]

Abstract

Pharmacists are trusted health care professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact for allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. This paper builds on existing studies and provides tools intended to help pharmacists provide optimal advice/interventions/strategies to patients with rhinitis. The Allergic Rhinitis and its Impact on Asthma (ARIA)-pharmacy ICP includes a diagnostic questionnaire specifically focusing attention on key symptoms and markers of the disease, a systematic Diagnosis Guide (including differential diagnoses), and a simple flowchart with proposed treatment for rhinitis and asthma multimorbidity. Key prompts for referral within the ICP are included. The use of technology is critical to enhance the management of allergic rhinitis. However, the ARIA-pharmacy ICP should be adapted to local healthcare environments/situations as regional (national) differences exist in pharmacy care. 74 7 1219 1236

Published
2019
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12. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

Author

Bousquet, J. Jean Schunemann, Holger J. Togias, Alkis and Erhola, Marina Hellings, Peter W. Zuberbier, Torsten Agache, Ioana Ansotegui, Ignacio J. Anto, Josep M. Bachert, Claus and Becker, Sven Bedolla-Barajas, Martin Bewick, Michael and Bosnic-Anticevich, Sinthia Bosse, Isabelle Boulet, Louis P. and Bourrez, Jean Marc Brusselle, Guy Chavannes, Niels Costa, Elisio Cruz, Alvaro A. Czarlewski, Wienczyslawa Fokkens, Wytske J. Fonseca, Joao A. Gaga, Mina Haahtela, Tari and Illario, Maddalena Klimek, Ludger Kuna, Piotr Kvedariene, Violeta Le, L. T. T. Larenas-Linnemann, Desiree Laune, Daniel Lourenco, Olga M. Menditto, Enrica Mullo, Joaquin and Okamoto, Yashitaka Papadopoulos, Nikos Nhan Pham-Thi Picard, Robert Pinnock, Hilary Roche, Nicolas Roller-Wirnsberger, Regina E. Rolland, Christine Samolinski, Boleslaw Sheikh, Aziz Toppila-Salmi, Sanna Tsiligianni, Ioanna Valiulis, Arunas Valovirta, Erkka Vasankari, Tuula Ventura, Maria-Teresa Walker, Samantha Williams, Sian Akdis, Cezmi A. and Annesi-Maesano, Isabella Arnavielhe, Sylvie Basagana, Xavier and Bateman, Eric Bedbrook, Anna Bennoor, K. S. Benveniste, Samuel Bergmann, Karl C. Bia, Slawomir Billo, Nils and Bindslev-Jensen, Carsten Bjermer, Leif Blain, Hubert Bonini, Mateo Bonniaud, Philippe Bouchard, Jacques Briedis, Vitalis and Brightling, Christofer E. Brozek, Jan Buhl, Roland and Buonaiuto, Roland Canonica, Giorgo W. Cardona, Victoria and Carriazo, Ana M. Carr, Warner Cartier, Christine Casale, Thomas Cecchi, Lorenzo Cepeda Sarabia, Alfonso M. and Chkhartishvili, Eka Chu, Derek K. Cingi, Cemal Colgan, Elaine de Sousa, Jaime Correia Courbis, Anne Lise Custovic, Adnan Cvetkosvki, Biljana D'Amato, Gennaro da Silva, Jane and Dantas, Carina Dokic, Dejand Dauvilliers, Yves Dedeu, Antoni De Feo, Giulia Devillier, Philippe Di Capua, Stefania and Dykewickz, Marc Dubakiene, Ruta Ebisawa, Motohiro and El-Gamal, Yaya Eller, Esben Emuzyte, Regina Farrell, John and Fink-Wagner, Antjie Fiocchi, Alessandro Fontaine, Jean F. and Gemicioglu, Bilun Schmid-Grendelmeir, Peter Gamkrelidze, Amiran Garcia-Aymerich, Judith Gomez, Maximiliano Gonzalez Diaz, Sandra Gotua, Maia Guldemond, Nick A. Guzman, Maria-Antonieta Hajjam, Jawad Hourihane, John O'B Humbert, Marc Iaccarino, Guido Ierodiakonou, Despo Ivancevich, Juan C. Joos, Guy Jung, Ki-Suck Jutel, Marek Kaidashev, Igor and Kalayci, Omer Kardas, Przemyslaw Keil, Thomas Khaitov, Mussa Khaltaev, Nikolai Kleine-Tebbe, Jorg Kowalski, Marek L. Kritikos, Vicky Kull, Inger Leonardini, Lisa and Lieberman, Philip Lipworth, Brian Carlsen, Karin C. Lodrup and Loureiro, Claudia C. Louis, Renaud Mair, Alpana Marien, Gert and Mahboub, Bassam Malva, Joao Manning, Patrick Keenoy, Esteban De Manuel Marshall, Gallen D. Masjedi, Mohamed R. and Maspero, Jorge F. Mathieu-Dupas, Eve Matricardi, Poalo M. and Melen, Eric Melo-Gomes, Elisabete Meltzer, Eli O. Mercier, Jacques Miculinic, Neven Mihaltan, Florin Milenkovic, Branislava Moda, Giuliana Mogica-Martinezl, Maria-Dolores and Mohammad, Yousser Montefort, Steve Monti, Ricardo and Morais-Almeida, Mario Moesges, Raft Munter, Lars Muraro, Antonella Murray, Ruth Naclerio, Robert Napoli, Luigi and Namazova-Baranova, Leila Neffen, Hugo Nekam, Kristoff Neou, Angelo Novellino, Enrico Nyembue, Dieudonne O'Hehir, Robin and Ohta, Ken Okubo, Kimi Onorato, Gabrielle Ouedraogo, Solange Pali-Schoell, Isabella Palkonen, Susanna Panzner, Peter Park, Hae-Sim Pepin, Jean-Louis Pereira, Ana-Maria and Pfaar, Oliver Paulino, Ema Phillips, Jim Plavec, Davor and Popov, Ted A. Portejoie, Fabienne Price, David Prokopakis, Emmanuel P. Pugin, Benoit Raciborski, Filip and Rajabian-Soderlund, Rojin Reitsma, Sietze Rodo, Xavier and Romano, Antonino Rosario, Nelson Rottem, Menahenm Ryan, Dermot Salimaki, Johanna Sanchez-Borges, Mario M. Sisul, Juan-Carlos Sole, Dirceu Somekh, David Sooronbaev, Talant and Sova, Milan Spranger, Otto Stellato, Cristina Stelmach, Rafael Ulrik, Charlotte Suppli Thibaudon, Michel To, Teresa and Todo-Bom, Ana Tomazic, V, Peter Valero, Antonio A. and Valenta, Rudolph Valentin-Rostan, Marylin van der Kleij, Rianne and Vandenplas, Olivier Vezzani, Giorgio Viart, Frederic and Vieg, Giovanni Wallace, Dana Wagenmann, Martin Wang, De Y. and Waserman, Susan Wickman, Magnus Williams, Dennis M. and Wong, Gary Wroczynski, Piotr Yiallouros, Panayiotis K. and Yorgancioglu, Arzu Yusuf, Osman M. Zar, Heahter J. Zeng, Stephane Zernotti, Mario Zhang, Luo Zhong, Nan S. and Zidarn, Mihaela ARIA Study Grp MASK Study Grp

Abstract

Background In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted “patient activation”, (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.

Published
2019

13. Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases

Author

Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhan, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhan, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., and Zidarn, Mihaela

Abstract

Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.

Published
2019
Full Text
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14. Feasibility of desensitizing children highly allergic to peanut by high-dose oral immunotherapy

Author

Reier-Nilsen, Tonje, Michelsen, Merethe Melbye, Carlsen, Karin C. Lodrup, Carlsen, Kai-Hakon, Mowinckel, Petter, Nygaard, Unni C., Namork, Ellen, Borres, Magnus P, Haland, Geir, Reier-Nilsen, Tonje, Michelsen, Merethe Melbye, Carlsen, Karin C. Lodrup, Carlsen, Kai-Hakon, Mowinckel, Petter, Nygaard, Unni C., Namork, Ellen, Borres, Magnus P, and Haland, Geir

Abstract

Background: There are limited data on the feasibility, efficacy and safety of high‐dose oral immunotherapy (OIT) in children highly allergic to peanuts. Objective: In children highly allergic to peanut, we primarily aimed to determine the feasibility of reaching the maximum maintenance dose (MMD) of 5000 mg peanut protein or, alternatively, a lower individual maintenance dose (IMD), by OIT up‐dosing. Secondarily, we aimed to identify adverse events (AEs) and determine factors associated with reaching a maintenance dose. Methods: The TAKE‐AWAY peanut OIT trial enrolled 77 children 5‐15 years old, with a positive oral peanut challenge. Fifty‐seven were randomized to OIT with biweekly dose step‐up until reaching MMD or IMD and 20 to observation only. Demographic and biological characteristics, AEs, medication and protocol deviations were explored for associations with reaching maintenance dose. Results: All children had anaphylaxis defined by objective symptoms in minimum two organ systems during baseline challenge. The MMD was reached by 21.1%, while 54.4% reached an IMD of median (minimum, maximum) 2700 (250, 4000) mg peanut protein, whereas 24.5% discontinued OIT. During up‐dosing, 19.4% experienced anaphylaxis. Not reaching the MMD was caused by distaste for peanuts (66.7%), unacceptable AEs (26.7%) and social reasons (6.7%). Increased peanut s‐IgG4/s‐IgE ratio (OR [95% CI]: 1.02 [1.00, 1.04]) was associated with reaching MMD. Conclusion: Although 75.5% of children with peanut anaphylaxis reached a maintenance dose of 0.25‐5 g, only 21.1% reached the MMD. Distaste for peanuts and AEs, including high risk of anaphylaxis, limited the feasibility of reaching MMD.

Published
2019
Full Text
View/download PDF

15. ARIA pharmacy 2018 Allergic rhinitis care pathways for community pharmacy AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Sante) \nPOLLAR (Impact of Air POLLution on Asthma and Rhinitis)\nGARD Demonstration project

Author

Bosnic-Anticevich, Sinthia, Costa, Elisio, Menditto, Enrica, Lourenco, Olga, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Buonaiuto, Roland, Chrystyn, Henry, Cvetkovski, Biljana, Di Capua, Stefania, Kritikos, Vicky, Mair, Alpana, Orlando, Valentina, Paulino, Ema, Salimaki, Johanna, Soderlund, Rojin, Tan, Rachel, Williams, Dennis M., Wroczynski, Piotr, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bedbrook, Anna, Bachert, Claus, Bewick, Mike, Bindslev-Jensen, Carsten, Brozek, Jan L., Canonica, Giorgio Walter, Cardona, Victoria, Carr, Warner, Casale, Thomas B., Chavannes, Niels H., de Sousa, Jaime Correia, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., Gaga, Mina, El-Gamal, Yehia, Fonseca, Joao, Fokkens, Wytske J., Antonieta Guzman, Maria, Haahtela, Tari, Hellings, Peter W., Illario, Maddalena, Carlos Ivancevich, Juan, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Khaltaev, Nikolai, Keil, Thomas, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree E., Laune, Daniel, Le, Lan T. T., Carlsen, Karin C. Lodrup, Mahboub, Bassam, Maier, Dieter, Malva, Joao, Manning, Patrick J., Morais-Almeida, Mario, Moesges, Ralph, Mullol, Joaquim, Munter, Lars, Murray, Ruth, Naclerio, Robert, Nannazova-Baranove, Leyla, Nekann, Kristof, Nyembue, Tshipukane Dieudonne, Okubo, Kimi, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikolaos G., Park, Hae-Sim, Pawankar, Ruby, Pfaar, Oliver, Phillips, Jim, Plavec, Davor, Popov, Todor A., Potter, Paul C., Prokopakis, Emmanuel P., Roller-Wirnsberger, Regina E., Rottenn, Menachem, Ryan, Dermot, Sannolinski, Bolesfaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan Carlos, Somekh, David, Stellato, Cristiana, To, Teresa, Todo-Bonn, Ana Maria, Tonnazic, Peter Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Valovirta, Errka, Ventura, Maria Teresa, Wagennnann, Martin, Wallace, Dana, Wasernnan, Susan, Wickman, Magnus, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario E., Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, Bousquet, Jean, Bosnic-Anticevich, Sinthia, Costa, Elisio, Menditto, Enrica, Lourenco, Olga, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Buonaiuto, Roland, Chrystyn, Henry, Cvetkovski, Biljana, Di Capua, Stefania, Kritikos, Vicky, Mair, Alpana, Orlando, Valentina, Paulino, Ema, Salimaki, Johanna, Soderlund, Rojin, Tan, Rachel, Williams, Dennis M., Wroczynski, Piotr, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bedbrook, Anna, Bachert, Claus, Bewick, Mike, Bindslev-Jensen, Carsten, Brozek, Jan L., Canonica, Giorgio Walter, Cardona, Victoria, Carr, Warner, Casale, Thomas B., Chavannes, Niels H., de Sousa, Jaime Correia, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., Gaga, Mina, El-Gamal, Yehia, Fonseca, Joao, Fokkens, Wytske J., Antonieta Guzman, Maria, Haahtela, Tari, Hellings, Peter W., Illario, Maddalena, Carlos Ivancevich, Juan, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Khaltaev, Nikolai, Keil, Thomas, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree E., Laune, Daniel, Le, Lan T. T., Carlsen, Karin C. Lodrup, Mahboub, Bassam, Maier, Dieter, Malva, Joao, Manning, Patrick J., Morais-Almeida, Mario, Moesges, Ralph, Mullol, Joaquim, Munter, Lars, Murray, Ruth, Naclerio, Robert, Nannazova-Baranove, Leyla, Nekann, Kristof, Nyembue, Tshipukane Dieudonne, Okubo, Kimi, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikolaos G., Park, Hae-Sim, Pawankar, Ruby, Pfaar, Oliver, Phillips, Jim, Plavec, Davor, Popov, Todor A., Potter, Paul C., Prokopakis, Emmanuel P., Roller-Wirnsberger, Regina E., Rottenn, Menachem, Ryan, Dermot, Sannolinski, Bolesfaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan Carlos, Somekh, David, Stellato, Cristiana, To, Teresa, Todo-Bonn, Ana Maria, Tonnazic, Peter Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Valovirta, Errka, Ventura, Maria Teresa, Wagennnann, Martin, Wallace, Dana, Wasernnan, Susan, Wickman, Magnus, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario E., Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, and Bousquet, Jean

Abstract

Pharmacists are trusted health care professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact for allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. This paper builds on existing studies and provides tools intended to help pharmacists provide optimal advice/interventions/strategies to patients with rhinitis. The Allergic Rhinitis and its Impact on Asthma (ARIA)-pharmacy ICP includes a diagnostic questionnaire specifically focusing attention on key symptoms and markers of the disease, a systematic Diagnosis Guide (including differential diagnoses), and a simple flowchart with proposed treatment for rhinitis and asthma multimorbidity. Key prompts for referral within the ICP are included. The use of technology is critical to enhance the management of allergic rhinitis. However, the ARIA-pharmacy ICP should be adapted to local healthcare environments/situations as regional (national) differences exist in pharmacy care.

Published
2019

16. Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar

Author

Anto, Josep M. Pinart, Mariona Akdis, Muebeccel Auffray, Charles Bachert, Claus Basagana, Xavier Carlsen, Kai-Hakon and Guerra, Stefano von Hertzen, Leena Illi, Sabina and Kauffmann, Francine Keil, Thomas Kiley, James P. Koppelman, Gerard H. Lupinek, Christian Martinez, Fernando D. Nawijn, Martijn C. Postma, Dirkje S. Siroux, Valerie Smit, Henriette A. Sterk, Peter J. Sunyer, Jordi Valenta, Rudolf and Valverde, Sergio Akdis, Cezmi A. Annesi-Maesano, Isabella and Ballester, Ferran Benet, Marta Cambon-Thomsen, Anne Chatzi, Leda Coquet, Jonathan Demoly, Pascal Gan, Weiniu and Garcia-Aymerich, Judith Gimeno-Santos, Elena Guihenneuc-Jouyaux, Chantal Haahtela, Tari Heinrich, Joachim Herr, Marie and Hohmann, Cynthia Jacquemin, Benedicte Just, Jocelyne and Kerkhof, Marjan Kogevinas, Manolis Kowalski, Marek L. and Lambrecht, Bart N. Lau, Susanne Carlsen, Karin C. Lodrup and Maier, Dieter Momas, Isabelle Noel, Patricia Oddie, Sam and Palkonen, Susanna Pin, Isabelle Porta, Daniela Punturieri, Antonello Ranciere, Fanny Smith, Robert A. Stanic, Barbara and Stein, Renato T. van de Veen, Willem van Oosterhout, Antoon J. M. Varraso, Raphaelle Wickman, Magnus Wijmenga, Cisca and Wright, John Yaman, Gorkem Zuberbier, Torsten Bousquet, Jean and WHO Collaborating Ctr Asthma

Abstract

Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the individual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology, and animal models. The last chapter deals with the understanding of the population-based IgE-associated phenotypes in children and adolescents, including age effect in terms of maturation, observed effects of early-life exposures and shift of focus from early life to pregnancy, gene-environment interactions, cohort effects, and time trends in patients with allergic diseases. This review helps to define phenotypes of allergic diseases in MeDALL. (J Allergy Clin Immunol 2012;129:943-54.)

Published
2012

17. Alpha-nicotinic acetylcholine receptor and tobacco smoke exposure: Effects on bronchial hyperresponsiveness in children

Author

Torjussen, Tale M., Carlsen, Karin C. Lodrup, Munthe-Kaas, Monica C., Mowinckel, Petter, Carlsen, Kai-Hakon, Helms, Peter J., Gerritsen, Jorrit, Whyte, Moira K., Lenney, Warren, Undlien, Dag E., Shianna, Kevin V., Zhu, Guohua, and Pillai, Sreekumar G.

Subjects
RISK, bronchial hyperresponsiveness, BIRTH, genetic analysis, ASSOCIATION, asthma, association study, OBSTRUCTIVE PULMONARY-DISEASE, respiratory tract diseases, LUNG-CANCER, CHRNA3, SNP rs8034191, SUBUNIT, cohort study, METHACHOLINE, SUSCEPTIBILITY LOCUS, POLYMORPHISMS
Abstract

Background: The CHRNA 3 and 5 genes on chromosome 15 encode the alpha subunits of the nicotinic acetylcholine receptor, mediating airway cholinergic activity. Polymorphisms are associated with cigarette smoking, chronic obstructive pulmonary disease, and lung cancer. Aims: To determine possible associations between CHRNA 3/5 SNP rs8034191 and asthma or lung function in children in one local and one replicate multinational population, and assess if tobacco smoke modified the associations. Materials and methods: The rs8034191 SNP genotyped in 551 children from the environment and childhood asthma (ECA) birth cohort study in Oslo, Norway, and in 516 families from six European centers [the Genetics of Asthma International Network (GAIN) study] was tested for genotypic or allelic associations to current or history of asthma, allergic sensitization (= one positive skin prick tests), bronchial hyperresponsiveness (BHR), and lung function (FEV1% of predicted and FEV1/FVC ratio over/ below the 5th percentile). Results: Although the TT and CT genotypes at SNP rs 8034191 were overall significantly associated with BHR (OR = 3.9, 95% CI 1.510.0, p = 0.005), stratified analyses according to exposure to maternal smoking in-utero or indoor smoking at 10 yrs of age showed significant association (OR = 4.4, 95% CI 1.512.6, p = 0.006 and OR 5.6, 95% CI 1.718.5, p = 0.004, respectively) only in the non-exposed and not in exposed children. The SNPBHR association was replicated in the non-tobacco-smoke-exposed subjects in one of the GAIN centers (BHR associated with the T allele (p = 0.034)), but not in the collated GAIN populations. Asthma, allergic sensitization, and lung function were not associated with the rs8034191 alleles. Conclusion: An interaction between tobacco smoke exposure and a CHRNA3/5 polymorphism was found for BHR in children, but CHRNA3/5 was not associated with asthma or lung function.

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