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7. ESCRT-III controls nuclear envelope reformation

Author

Olmos, Yolanda, Hodgson, Lorna, Mantell, Judith, Verkade, Paul, and Carlton, Jeremy G.

Subjects
Cell division -- Research, Cell research, Nuclear membranes -- Properties, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

During telophase, the nuclear envelope (NE) reforms around daughter nuclei to ensure proper segregation of nuclear and cytoplasmic contents (1-4). NE reformation requires the coating of chromatin by membrane derived from the endoplasmic reticulum, and a subsequent annular fusion step to ensure that the formed envelope is sealed (1,2,4,5). How annular fusion is accomplished is unknown, but it is thought to involve the p97 AAA-ATPase complex and bears a topological equivalence to the membrane fusion event that occurs during the abscission phase of cytokinesis (1,6). Here we show that the endosomal sorting complex required for transport-III (ESCRT-III) machinery localizes to sites of annular fusion in the forming NE in human cells, and is necessary for proper post-mitotic nucleocytoplasmic compartmentalization. The ESCRT-III component charged multivesicular body protein 2A (CHMP2A) is directed to the forming NE through binding to CHMP4B, and provides an activity essential for NE reformation. Localization also requires the p97 complex member ubiquitin fusion and degradation 1 (UFD1). Our results describe a novel role for the ESCRT machinery in cell division and demonstrate a conservation of the machineries involved in topologically equivalent mitotic membrane remodelling events., The ESCRT-III complex performs a topologically unique membrane fusion, allowing the release of enveloped retroviruses during viral budding, intraluminal vesicles during multivesicular body biogenesis, and daughter cells during the abscission [...]

Published
2015

10. AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody

Author

Merigliano, Chiara, primary, Burla, Romina, additional, La Torre, Mattia, additional, Del Giudice, Simona, additional, Teo, Hsiangling, additional, Liew, Chong Wai, additional, Chojnowski, Alexandre, additional, Goh, Wah Ing, additional, Olmos, Yolanda, additional, Maccaroni, Klizia, additional, Giubettini, Maria, additional, Chiolo, Irene, additional, Carlton, Jeremy G., additional, Raimondo, Domenico, additional, Vernì, Fiammetta, additional, Stewart, Colin L., additional, Rhodes, Daniela, additional, Wright, Graham D., additional, Burke, Brian E., additional, and Saggio, Isabella, additional

Published
2021
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14. LAP1 supports nuclear plasticity during constrained migration

Author

Jung-Garcia, Yaiza, primary, Maiques, Oscar, additional, Rodriguez-Hernandez, Irene, additional, Fanshawe, Bruce, additional, Domart, Marie-Charlotte, additional, Renshaw, Matt, additional, Marti, Rosa M, additional, Matias-Guiu, Xavier, additional, Collinson, Lucy M, additional, Sanz-Moreno, Victoria, additional, and Carlton, Jeremy G, additional

Published
2021
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16. Human AKTIP interacts with ESCRT proteins and functions at the midbody in cytokinesis

Author

Merigliano, Chiara, primary, Burla, Romina, additional, La Torre, Mattia, additional, Del Giudice, Simona, additional, Teo, Hsiang Ling, additional, Liew, Chong Wai, additional, Goh, Wah Ing, additional, Chojnowski, Alexandre, additional, Olmos, Yolanda, additional, Chiolo, Irene, additional, Carlton, Jeremy G., additional, Raimondo, Domenico, additional, Verni, Fiammetta, additional, Stewart, Colin, additional, Rhodes, Daniela, additional, Wright, Graham D., additional, Burke, Brian, additional, and Saggio, Isabella, additional

Published
2020
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18. CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope

Author

Ventimiglia, Leandro N., primary, Cuesta-Geijo, Miguel Angel, additional, Martinelli, Nicolas, additional, Caballe, Anna, additional, Macheboeuf, Pauline, additional, Miguet, Nolwenn, additional, Parnham, Ian M., additional, Olmos, Yolanda, additional, Carlton, Jeremy G., additional, Weissenhorn, Winfried, additional, and Martin-Serrano, Juan, additional

Published
2018
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19. ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

Author

Monypenny, James, primary, Milewicz, Hanna, additional, Flores-Borja, Fabian, additional, Weitsman, Gregory, additional, Cheung, Anthony, additional, Chowdhury, Ruhe, additional, Burgoyne, Thomas, additional, Arulappu, Appitha, additional, Lawler, Katherine, additional, Barber, Paul R., additional, Vicencio, Jose M., additional, Keppler, Melanie, additional, Wulaningsih, Wahyu, additional, Davidson, Sean M., additional, Fraternali, Franca, additional, Woodman, Natalie, additional, Turmaine, Mark, additional, Gillett, Cheryl, additional, Franz, Dafne, additional, Quezada, Sergio A., additional, Futter, Clare E., additional, Von Kriegsheim, Alex, additional, Kolch, Walter, additional, Vojnovic, Borivoj, additional, Carlton, Jeremy G., additional, and Ng, Tony, additional

Published
2018
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