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1. Biomechanical characteristics of different methods of neo-chordal fixation to the papillary muscles

Author

Luis Fernández, Amparo Martínez Monzonís, Mohammad M. El‐Diasty, Carmen Álvarez‐Lorenzo, Ángel Concheiro, Ángel L. Fernández, Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas, Universidade de Santiago de Compostela. Departamento de Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica, and Universidade de Santiago de Compostela. Departamento de Física Aplicada

Subjects
Male, Pulmonary and Respiratory Medicine, Chordal replacement, Sutures, Suture Techniques, Humans, Surgery, Papillary Muscles, Cardiology and Cardiovascular Medicine, Mitral valve repair, Polytetrafluoroethylene, Biomechanical Phenomena
Abstract

Background and Aim of the Study Several techniques have been described for neo-chordal fixation to the papillary muscles without any reported clinical differences. The objective of this study is to compare in vitro the biomechanical properties of four of these common techniques. Methods We studied the biomechanical properties of expanded polytetrafluoroethylene neo-chordal fixation using four techniques: nonknotted simple stitch, nonknotted figure-of-eight stitch, knotted pledgeted mattress stitch, and knotted pledgeted stitch using commercially available prefabricated loops. Neo-chordae were submitted to a total of 20 traction-relaxation cycles with incremental loads of 1, 2, and 4 N. We calculated the elongation, the force-strain curve, elasticity, and the maximum tolerated load before neo-chordal failure. Results The elongation of the neo-chordae was lowest in the simple stitch followed by the figure-of-eight, the pledgeted mattress, and he commercially prefabricated loops (p

Published
2022

2. Contributors

Author

José Francisco Noguera Aguilar, Mohammed Alhayek-Aí, Pedro A. Alonso Aguirre, Paula Álvarez-Chaver, Sara Alvarez-Gonzalez, Lucía Álvarez-Santullano, Javier Castro Alvariño, Jorge Amigo, Luis M. Antón Aparicio, Natalia Aptsiauri, María Sánchez Ares, Begoña Campos Balea, Paula Vieiro Balo, Lucía Barcia, Germán Bou, Vanesa Balboa Barreiro, Isaac Martínez Bendayán, Mónica Bernal, Pedro Carpintero Briones, Elena Brozos-Vázquez, Begoña Bravo Bueno, Alba Burundarena, Antonio Gómez Caamaño, José Manuel Mera Calviño, Marcos Calvo, Sonia Candamio-Folgar, Alejandra Cardelle-Cobas, Ángel Carracedo, Ainhoa Carrasco, Álvaro Gómez Castro, Ana María Carballo Castro, Alberto Cepeda, Alfonso Cepeda-Emiliani, Ángel Concha, Benito González Conde, Oscar J. Cordero, Alberto Centeno Cortés, Jesús Paredes Cotoré, Patricia Calvo Crespo, Alain García de Castro, Loretta De Chiara, Enrique González de la Ballina González, Sofía Rodríguez Martínez de Llano, Manuel Núñez Deben, M. del Carmen Corujeira Rivera, Cristina Méndez Díaz, Sonia Pértega Díaz, Leticia García Diéguez, Antonio Rodríguez D'Jesús, Ramón Vázquez Dourado, Alba Gómez Dovigo, Paloma Sosa Fajardo, Nereida Fernández Fernández, Rafaela Soler Fernández, Rosalía Fernández, Sergio Manuel Estévez Fernández, Carlos Fernandez-Lozano, Ceres Fernández-Rozadilla, Raquel Sardina Ferreiro, Silvia Varela Ferreiro, Roberto García Figueiras, Angélica Figueroa, Lydia Fraga Fontoira, Carlos M.N Franco, María Gallardo-Gómez, Concepción Crespo García, Esther Rodríguez García, Alba García-López, Federico Garrido, Javier Aguirrezabalaga González, Joaquín González-Carreró, Diego Gonzalez-Rivas, Begoña Graña-Suárez, Vicent Hernández, Paula Peleteiro Higuero, Héctor Lázare Iglesias, Orlando Fernández Lago, Alexandre Lamas, Jose Liñares-Blanco, María Jose Martinez-Sapiña Llanas, Fernando Fernández López, José Ramón Antúnez López, Rafael López-López, Anael López-Novo, Carmen Álvarez Lorenzo, Miguel Pereira Loureiro, Ramiro Manuel Macenlle García, Shirly Margarita Nieves Maldonado, Sara Seijas Marcos, Eva Martí Marqués, Cristina González Martín, Arantza Germade Martínez, Nieves Martínez Lago, Gala Martínez-Bernal, Julia Martínez-Pérez, Virginia Mato-Abad, Silvia Louzao Méndez, Manuel Bustamante Montalvo, Beatriz Romero Mosquera, Catuxa Celeiro Muñoz, Cristian R. Munteanu, Ángel Concheiro Nine, Alejandra García Novoa, Martina Lema Oreiro, Francisco Ruíz-Cabello Osuna, María Otero, Susana A. Otero Muinelo, Pilar Díaz Parada, Jesús P. Paredes Cotoré, Alejandro Pazos, Alejandro Pazos García, Carla Pazos García, Nieves Pedreira, María Teresa Seoane Pillado, Susana López Piñeiro, Margarita Poza, Natalia Cal Purriños, Francisco Queipo, Patricia Regal, Fernando Zelaya Reinquet, María Teresa Vázquez Rey, Andrés Dacal Rivas, José Luis Ulla Rocha, Alejandro Ledo Rodríguez, Francisco Javier González Rodríguez, Gerardo Baños Rodríguez, María Teresa García Rodríguez, Máximo Fraga Rodríguez, Miriam Rojas, Leopoldo López Rosés, Marta Covela Rúa, Juan Ruiz-Bañobre, Clara Ruiz-Ponte, Francisco Javier Maestro Saavedra, Víctor Sacristán Santos, Ismael Said-Criado, Aliuska Duardo Sánchez, Paloma González Santamaría, Rodrigo A.S. Sardenberg, Antonio Jurjo Sieira, Paulino Pais Silva, Rosa Fungueiriño Suarez, Tatiana María Civeira Taboada, Adriana Barreiro Trillo, Rosa Trillo, M. Lidia Vázquez-Tunas, Alfonso Martínez Turnes, Begoña Taboada Valladares, Manuel Valladares-Ayerbes, Vanesa Val Varela, Rubén Varela-Calviño, Beatriz I. Vázquez, Carla Blanco Vázquez, Juan Turnes Vázquez, Pablo Parada Vázquez, Vanesa Vilanova Vázquez, José M. Vázquez-Naya, Francisca Vázquez-Rivera, Alberto Veiga, Yolanda Vidal-Ínsua, Alba María Arceo Vilas, and Ignacio Couto Worner

Published
2022
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3. Handbook of Molecularly Imprinted Polymers

Author

Carmen Alvarez-Lorenzo, Angel Concheiro, Carmen Alvarez-Lorenzo, and Angel Concheiro

Subjects
Molecular imprinting, Imprinted polymers
Abstract

This handbook provides a useful guide to preparing molecularly imprinted polymers (MIPs) for diverse practical applications. The first chapter covers the general aspects of molecular imprinting technology. The following chapters focus on specific applications, such as MIPs for sample concentration, MIPs for chromatography and related techniques, MIPs as sensor components, MIPs as traps for medical and bioremediation, MIPs as catalysts and artificial enzymes, and MIPs as components of drug delivery systems. All chapters of the handbook follow a common structure: •interest of the MIP approach for that application •specific aspects of the synthesis of MIPs for this aim (requirements and general recipes) •representative examples of MIPs and their performance for that application •a look to the future.

Published
2013

4. Smart Materials for Drug Delivery : Volume 2

Author

Carmen Alvarez-Lorenzo, Angel Concheiro, Carmen Alvarez-Lorenzo, and Angel Concheiro

Subjects
Smart materials, Drug delivery systems--Technological innovations
Abstract

Smart materials, which can change properties when an external stimulus is applied, can be used for the targeted drug delivery of an active molecule to a specific site in the correct dosage. Different materials such as liposomes, polymeric systems, nanomaterials and hydrogels can respond to different stimuli such as pH, temperature and light and these are all attractive for controlled release applications. With so many papers available on smart and stimuli-responsive materials for drug delivery applications it's hard to know where to start reading about this exciting topic. This two volume set brings together the recent findings in the area and provides a critical analysis of the different materials available and how they can be applied to advanced drug delivery systems. With contributions from leading experts in the field, including a foreword from distinguished scientist Nicholas Peppas, The University of Texas at Austin, USA, the book will provide both an introduction to the key areas for graduate students and new researchers in the stimuli-responsive field as well as serving as a reference for those already working on fundamental materials research or drug delivery applications.

Published
2013

5. Smart Materials for Drug Delivery : Volume 1

Author

Carmen Alvarez-Lorenzo, Angel Concheiro, Carmen Alvarez-Lorenzo, and Angel Concheiro

Subjects
Smart materials, Drug delivery systems--Technological innovations
Abstract

Smart materials, which can change properties when an external stimulus is applied, can be used for the targeted drug delivery of an active molecule to a specific site in the correct dosage. Different materials such as liposomes, polymeric systems, nanomaterials and hydrogels can respond to different stimuli such as pH, temperature and light and these are all attractive for controlled release applications. With so many papers available on smart and stimuli-responsive materials for drug delivery applications it's hard to know where to start reading about this exciting topic. This two volume set brings together the recent findings in the area and provides a critical analysis of the different materials available and how they can be applied to advanced drug delivery systems. With contributions from leading experts in the field, including a foreword from distinguished scientist Nicholas Peppas, The University of Texas at Austin, USA, the book will provide both an introduction to the key areas for graduate students and new researchers in the stimuli-responsive field as well as serving as a reference for those already working on fundamental materials research or drug delivery applications.

Published
2013

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