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Abstract Background Intimate partner violence (IPV) is common globally, but there is a lack of research on how to intervene early with men who might be using IPV. Building on evidence supporting the benefits of online interventions for women victim/survivors, this study aims to test whether a healthy relationship website (BETTER MAN) is effective at improving men’s help seeking, their recognition of behaviours as IPV and their readiness to change their behaviours. Methods/design In this two-group, pragmatic randomised controlled trial, men aged 18–50 years residing in Australia who have been in an adult intimate relationship (female, male or non-binary partner) in the past 12 months are eligible. Men who report being worried about their behaviour or have had others express concerns about their behaviour towards a partner in the past 12 months will be randomised with a 1:1 allocation ratio to receive the BETTER MAN website or a comparator website (basic healthy relationships information). The BETTER MAN intervention includes self-directed, interactive reflection activities spread across three modules: Better Relationships, Better Values and Better Communication, with a final “action plan” of strategies and resources. Using an intention to treat approach, the primary analysis will estimate between-group difference in the proportion of men who report undertaking help-seeking behaviours for relationship issues in the last 6 months, at 6 months post-baseline. Analysis of secondary outcomes will estimate between-group differences in: (i) mean score of awareness of behaviours in relationships as abusive immediately post-use of website; (ii) mean score on readiness to change immediately post-use of website and 3 months after baseline; and (iii) cost-effectiveness. Discussion This trial will evaluate the effectiveness of an online healthy relationship tool for men who may use IPV. BETTER MAN could be incorporated into practice in community and health settings, providing an evidence-informed website to assist men to seek help to promote healthy relationships and reduce use of IPV. Trial registration ACTRN12622000786796 with the Australian New Zealand Clinical Trials Registry: 2 June 2022. Version: 1 (28 September 2023).

This study aims at explaining the impact of Instagram social media influencers on behavioural intentions (i.e., intentions to interact with them and recommend them, and also purchase the products they endorse or post). It focuses on influencers’ expertise and their role as opinion and taste leaders. Based on opinion leadership theory, a survey was conducted on 210 Instagram users. Main findings reveal that post originality, uniqueness, and quality impact on influencers’ opinion leadership which, in turn, impacts on behavioural intentions. Influencers’ expertise impacts on the intention to recommend the influencers and purchase the products posted, while influencers’ taste leadership only influences the intention to interact with them. Few papers analyse the direct effects of influencers’ expertise and opinion and taste leadership on followers’ behavioural intentions. Consequently, when designing a social media marketing campaign influencers’ selection should be made according to those traits which stimulate specific behaviours such as fostering interaction, increase electronic word of mouth or persuade to purchase the products posted. In case of product endorsements, selecting influencers with acknowledged expertise is recommended as they will cause an impact on the intention to purchase endorsed products. Influencers perceived as opinion leaders have an overall influence on their followers’ behavioural intentions.

This paper presents a complete bibliometric analysis of Aitchison’s 1986 seminal book “The Statistical Analysis of Compositional Data.” We have set three objectives. The first is to analyze the academic structure of Aitchison’s 1986 book. Results reveals that although the work has received citations uninterruptedly since its publication, the number of these has increased very significantly over the past 4 years. This is due to the significant increase in the number of publications on the theme of “Compositional Data Analysis” in fields related to “geoscience” over the last few years. The second objective is to determine which main journals Aitchison’s book has been cited in. The results highlight that the main journals are indexed under the following WoS category: “Geosciences, Multidisciplinary” and “Ecology.” Of these, “Mathematical Geosciences” and “Computers, Geosciences” stand out. The third objective is to determine the main topics analyzed in the principal papers published by authors citing Aitchison’s book. Our results show that the keywords in the main papers to have cited Aitchison’s 1986 book originate from the geoscience field, since many of them are related to concepts directly linked to this field and refer to terms related to “biodiversity,” “geodiversity,” “geoheritage,” and “georesources.” Lastly, the analysis shows how the CoDA methodology is now in a phase of exponential growth, expanding to other fields. This implies that geoscience is becoming consolidated in the scientific literature as one of the branches of modern science that has given rise to a new mathematical theory of great impact.

We present a rare challenging case of metastatic non-small cell lung cancer with Epstein-Barr virus positivity that was also diagnosed with pulmonary tuberculosis at the same time. Palliative chemotherapy gemcitabine and carboplatin was started after two weeks of anti-tuberculosis treatment with the hopes that this period would be sufficient to keep acid fast bacilli non-viable to minimise risk of tuberculosis re-activation due to chemotherapy induced immunosuppression. She completed four cycles of chemotherapy and six months of anti-tuberculosis treatment with good results and minimal side effects. Two years later, there was disease recurrence in cervical and mediastinal lymph nodes which was treated with local treatment i.e. surgery and palliative radiotherapy. It has been two years since last radiotherapy and overall more than five years since diagnosis with no active disease at present. Given the complexity and rarity of this case, significant multidisciplinary team involvement, including oncologists and radiation oncologists, pulmonologists with special interest in tuberculosis and pathologists was necessary throughout.

Background: The current spread of carbapenemase-producing Enterobacterales (CPE) is a great concern. Methods: We recovered 198 CPE from 162 patients admitted in our Hospital (March 2014-March 2016) during the R-GNOSIS European Project. Microbiological features and plasmid characteristics of CPE recovered from patients co-colonized with multiple CPE were studied. Findings: Thirty patients (18.5%; CI 95%= 12.5%–24.5%) presented co-colonization with multiple CPE producing the same (CPE-SC) (15.4%) or a different carbapenemase (CPE-DC) (4.3%). OXA-48 (83.3%) was the most frequent carbapenemase, followed by VIM-1 (26.7%), NDM-1 (10%) and KPC-3 (3.3%). CPE-DC-patients had longer admissions [63 days (20–107)] than the other patients. Moreover, hospital stay until CPE detection was lower [9 days (5–14)] (p = 0.0052) in CPE-SC-patients than in those with a single colonization; 56% showed co-colonization in the first positive sample, although most of them had previous admissions and had received multiple antibiotic treatments. CPE were more frequently recovered in clinical samples from co-colonized [CPE-DC (28.6%), CPE-SC (24%)] patients than from patients with a single CPE (15.2%). Among CPE-SCOXA-48 [80% (p = 0.11)], K. pneumoniae [88% (p = 0.006)] and E. coli [84% (p

Within the process of progressive digitization of materials and tools for teaching and distance learning of a subject of introduction to Microeconomics (quarterly, in year three of the Degree in Social Work), taught by the authors at the National University of Distance Education (UNED), a virtual assistant in the form of chatbot, or conversational robot, called EconBot, has been designed and made available to students from 2017. This paper presents the reasons that led to its adoption, the process of its development, differentiating two phases, its characteristics and functions, the assessment of its usefulness and the role of teachers in the implementation of this type of technological innovation.

This study presents a comprehensive bibliometric analysis of the paper published by John Aitchison in the Journal of the Royal Statistical Society. Series B (Methodological) in 1982. Having recently reached the milestone of 35 years since its publication, this pioneering paper was the first to illustrate the use of the methodology "Compositional Data Analysis" or "CoDA". By October 2019, this paper had received over 780 citations, making it the most widely cited and influential article among those using said methodology. The bibliometric approach used in this study encompasses a wide range of techniques, including a specific analysis of the main authors and institutions to have cited Aitchison' paper. The VOSviewer software was also used for the purpose of developing network maps for said publication. Specifically, the techniques used were co-citations and bibliographic coupling. The results clearly show the significant impact the paper has had on scientific research, having been cited by authors and institutions that publish all around the world.

Background: Accelerating the diagnosis of bacteremia is one of the biggest challenges in clinical microbiology departments. The fast establishment of a correct treatment is determinant on bacteremic patients’ outcomes. Our objective was to evaluate the impact of antimicrobial therapy and clinical outcomes of a rapid blood culture workflow protocol in positive blood cultures with Gram-negative bacilli (GNB). Methods: A quasi-experimental before–after study was performed with two groups: (i) control group (conventional work-protocol) and (ii) intervention group (rapid workflow-protocol: rapid identification by Matrix-Assisted Laser Desorption/Ionization-Time-Of-Flight (MALDI-TOF) and antimicrobial susceptibility testing (AST) from bacterial pellet without overnight incubation). Patients were divided into different categories according to the type of intervention over treatment. Outcomes were compared between both groups. Results: A total of 313 patients with GNB-bacteremia were included: 125 patients in the control group and 188 in the intervention. The time from positive blood culture to intervention on antibiotic treatment decreased from 2.0 days in the control group to 1.0 in the intervention group (p < 0.001). On the maintenance of correct empirical treatment, the control group reported 2.0 median days until the clinical decision, while in the intervention group was 1.0 (p < 0.001). In the case of treatment de-escalation, a significant difference between both groups (4.0 vs. 2.0, p < 0.001) was found. A decreasing trend on the change from inappropriate treatments to appropriate ones was observed: 3.5 vs. 1.5; p = 0.12. No significant differences were found between both groups on 7-days mortality or on readmissions in the first 30-days. Conclusions: Routine implementation of a rapid workflow protocol anticipates the report of antimicrobial susceptibility testing results in patients with GNB-bacteremia, decreasing the time to effective and optimal antibiotic therapy.

In 1986, a new syndrome was described in Taiwan secondary to hypervirulent K. pneumoniae (hvKP), and its main feature was the ability to cause severe infection in young and immunocompetent hosts. Their virulence is explained by the efficient acquisition of iron and an increase in capsule production, which confer the characteristic hypermucoviscous phenotype. Most of these cases have been described in Asia and subsequently spread to America and Europe, where their prevalence is much lower. We present four cases of bacteremia and liver abscesses secondary to hypervirulent K. pneumoniae, two of them associated with endophthalmitis. K. pneumoniae isolates recovered from two of the patients belonged to capsular serotype K1 (genes wzx_K1 and magA), while the other two were K2 (gene wzy_K2). Both of the K1 isolates were classified into a ST23, and isolates of serotype K2 belonged to the ST375 and ST881 clones.In Europe, hvKP isolates are less frequently recovered, mostly associated with Asian citizens or travelers, which was not the case in our patients. K1 capsular serotype is a major cause of primary liver abscess and secondary septic embolus, and K2 is associated with secondary liver abscess. Although these hypervirulent variants usually affect immunocompetent patients as in our cases, diabetes mellitus is a major risk factor for the most invasive cases, with concomitant poor prognosis. Identification of hypervirulent K. pneumoniae serotypes K1 and K2 should be considered as part of the microbiological diagnosis of community-acquired liver abscess due to their clinical implications. Keywords: Hypermucoviscous Klebsiella pneumoniae, Liver abscess, Community acquired infection, MLST

The aim of the research was to develop a theoretical approach to describe the emotional and techno-ontological logic of mathematics teachers during distance learning during the COVID-19 pandemic and the impact of their emotional state on the learning process. The research approach used in this paper belongs to the qualitative paradigm. The study involved teachers and students from universities in Ecuador, both private and public. The study observed the behavior of teachers and students, analyzed the use of technology in mathematical activities, and analyzed personal opinions about the learning process of the participants of the study. A digital observation guide and open-ended interviews were used to collect data. The qualitative analysis program Atlas. Ti was used to analyze the data. The program created three categories: andragogical heterotopia of mathematics, emotional scar in teacher preparation, and perceptions of the educational process. As the results of the research showed, there was a deficit of digital professional training of teachers in the university teaching of mathematics. As a result of the research work carried out, a theoretical approach is proposed, through which it is possible to avoid the manifestation of techno-ontological logical emotions in mathematics teachers in Ecuadorian universities.

Objetivo: Analizar los artículos sobre usabilidad publicados durante el periodo 1971-2005 desde el punto de vista bibliométrico. Material y Métodos: Para obtener los trabajos se interrogaron las bases de datos del CSIC, Social Science Citation Index, Science Citation Index, PsycInfo, MEDLINE e Inspec mediante estrategias de búsqueda diseñadas ad hoc para cada base de datos. Se calcularon los índices de aporte, aporte específico y solapamiento y los indicadores de evolución de la productividad científica, productividad de las instituciones de trabajo y de las revistas, y distribución de las revistas por área de conocimiento. Resultados: Se ha observado un crecimiento exponencial de los artículos publicados, más acusado en el último quinquenio. Las instituciones más productivas son fundamentalmente universitarias y estadounidenses y las revistas más productivas pertenecen al campo de la informática, ingeniería y psicología. Conclusiones: en la actualidad existe una incógnita sobre la consideración de la usabilidad como ciencia o disciplina científica, ya que no cuenta con un currículo formativo acorde, ni un perfil profesional determinado, ni un área específica de conocimiento en la que se pueda englobar.

Introducción: El manejo de la infección todavía es un reto en el tratamiento del desnutrido grave porque la inmunosupresión y la anemia concomitante comprometen la respuesta inflamatoria. Objetivo: Comparar la respuesta inflamatoria entre niños con desnutrición aguda grave tipo marasmo y kwashiorkor y niños eutróficos con y sin anemia (grupos control), mediante la medición de los niveles de proteína C reactiva (PCR) y de las citocinas pro-inflamatorias IL-8, IL-1β, IL-6, IL-10, TNFα e IL-12. Metodología: Se realizó un estudio de corte transversal, donde se determinaron los niveles de algunos indicadores de la respuesta inflamatoria como proteína C reactiva (PCR), citocinas pro-inflamatorias como IL-8, IL-1β, IL-6, IL-10, TNF-α e IL-12p70, hemoglobina y ferritina en un grupo de 40 niños: 10 con marasmo, 10 con kwashiorkor, 10 eutróficos con anemia y 10 eutróficos sin anemia. Resultados. La PCR fue significativamente mayor en desnutridos que en eutróficos. Las concentraciones de las citocinas pro-inflamatorias fueron más altas en niños con kwashiorkor seguidos de eutróficos con anemia, marasmáticos y eutróficos sin anemia. La hemoglobina se correlacionó negativamente con los niveles de IL-8 (r=-0,409 p=0,009), IL-6 (r=-0,442 p=0,004) e IL-10 (r=-0,436 p=0,005). Conclusión. Los niños con desnutrición aguda grave producen una respuesta inflamatoria con aumento en los niveles de la PCR y de citocinas pro-inflamatorias que indican infección aun cuando no presenten signos, lo cual apoya la recomendación del protocolo de la OMS de medicarlos con antibioticos. Adicionalmente, estos resultados sugieren que las citocinas pro-inflamatorias podrian participar en la patogenesis de la anemia en pacientes con o sin desnutricion.

El consumo de libros científicos electrónicos es aún muy reducido en el ámbito universitario, debido en parte a la necesidad de realizar una lectura de trabajo durante más tiempo y a problemas de usabilidad y de diseño de las interfaces. En este trabajo se aborda el grado de satisfacción de uso del e-reader, el tipo de lecturas que se realizan en estos dispositivos y el nivel de conocimiento, uso y satisfacción con la colección digital de las bibliotecas universitarias. Para ello se ha realizado una encuesta digital dirigida a estudiantes de las universidades públicas españolas que durante el curso 2012-2013 impartieron docencia en el Grado de Información y Documentación. Los resultados muestran que pese a que el uso del e-reader está muy extendido, el ordenador sigue siendo el dispositivo más empleado para la lectura y consulta del libro científico digital.

Objectives The in vivo selection of E157Q plus R263K has not been reported in patients treated with coformulated bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF). To the best of our knowledge, we hereby report the first case of high-grade INSTI resistance associated with the presence of these aminoacidic substitutions in a treatment-experienced HIV patient treated with BIC/FTC/TAF. Methods Clinical case report and review of the literature. Results A heavily treatment-experienced patient was switched to BIC/FTC/TAF due to drug–drug interactions after being diagnosed with disseminated Mycobacterium avium-intracellulare disease. He had been treated before with raltegravir with poor adherence. No mutations in the integrase gene were detected 1 year after finishing treatment with raltegravir. Months after being switched to BIC/FTC/TAF, and again with poor adherence documented, virological failure (VF) was detected. The polymorphic substitution E157Q and the resistance mutation R263K in the integrase gene were detected, as well as M184V, among other mutations in the reverse transcriptase gene. The patient is currently being treated with dolutegravir q12h plus boosted darunavir along with directly observed treatment, and for the first time in 20 years, plasmatic viral load values are below 100 copies/mL. Conclusions This case illustrates that the combination of E157Q and R263K plus M184V can be selected in vivo in a clinical scenario of poor adherence with BIC/FTC/TAF, although it is a very rare phenomenon. Previous VF with first-generation integrase strand transfer inhibitors (INSTIs) should be kept in mind when switching patients to second-generation INSTIs. [ABSTRACT FROM AUTHOR]