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This document reports the final and manufacturing design of the MITICA Control Room.

The article presents the results of the research activity carried out within the framework of the European project H2020 REFLOW, which aims to build an integrated approach for the development of innovative participatory practices dedicated to urban circular metabolisms. As a result of the survey conducted on the application of collaborative models for the urban circular economy, it emerged that there is no shared operational strategy that can be adopted for the circular development of complex systems, such as cities. Based on this premise, this paper offers a new perspective on how to build and validate a transitional pathway for the development of circular cities through the adoption of a design-oriented approach that orchestrates different resources and capacities.

Background: In the phase 2 CAMMS223 trial (NCT00050778), alemtuzumab significantly improved clinical and MRI outcomes versus subcutaneous interferon beta-1a over 3 years in treatment-naive patients with relapsing–remitting MS. Here, we assess efficacy and safety of alemtuzumab over 12 years in CAMMS223 patients who enrolled in the CAMMS03409 extension (NCT00930553), with available follow-up through the subsequent TOPAZ extension (NCT02255656). Methods: In CAMMS223, patients received 2 alemtuzumab courses (12 mg/day; baseline: 5 days; 12 months later: 3 days); 22% received a third course. In the open-label, nonrandomized extensions, patients could receive as-needed additional alemtuzumab or other disease-modifying therapies. Results: Of 108 alemtuzumab-treated patients in CAMMS223, 60 entered the CAMMS03409 extension; 33% received a total of 2 alemtuzumab courses, and 73% received no more than 3 courses through Year 12. Over 12 years, annualized relapse rate was 0.09, 71% of patients had stable or improved Expanded Disability Status Scale scores, and 69% were free of 6-month confirmed disability worsening. In Year 12, 73% of patients were free of MRI disease activity. Cumulatively throughout the extensions (Years 7–12), 34% of patients had no evidence of disease activity. Adverse event (AE) incidence declined through Year 12. Infusion-associated reactions peaked at first course and declined thereafter. Cumulative thyroid AE incidence was 50%; one immune thrombocytopenia event occurred, and there were no autoimmune nephropathy cases. Conclusions: Alemtuzumab efficacy was maintained over 12 years in CAMMS223 patients, with 73% receiving no more than three courses. The safety profile in this cohort was consistent with other alemtuzumab clinical trials. © 2020, The Author(s).

A folha de erva-mate é consumida tradicionalmente e conhecida pela alta concentração de polifenóis. O método espectrofotométrico comumente usado para determinar o Teor de Polifenóis Totais (CFT) é o Folin-Ciocalteu. O objetivo desse trabalho foi adaptar o método de Folin-Ciocalteau para determinar o CTF em extrato de erva-mate visando a redução do tempo de reação, proporcionando eficiência e economia. Para tanto, a cinética da reação envolvida na análise do extrato de erva-mate foi estudada, sendo observada uma mudança de inclinação da curva cinética em 30 minutos de reação. Para avaliar a adequação do tempo de reação da análise em 30 minutos, a curva padrão foi obtida por três analistas diferentes e os resultados comparados à análise utilizando tempo de reação de 2 horas, conforme método Folin-Ciocalteu. Os resultados foram expressos em equivalente de ácido gálico (EAG). Os resultados de absorbância variaram de 0,004 ± 0,004 (0 mg EAG L-1)a 1,187 ± 0,100 (1000 mg EAG L-1) para a reação de 2 horas. Na reação de 30 minutos estes valores variaram de 0,005 ± 0,004 (0 mg EAG L-1) a 1,197 ± 0,022 (1000 mg EAG L-1). Estes métodos foram utilizados para quantificar o CFT em folhas de erva-mate e osresultados foram de 58,33 ± 3,90 mg EAG g-1(método tradicional) e de 57,77 ± 2,70 mg EAG g-1(método adaptado). Estes resultados demonstram a reprodutibilidade no método adaptado, mostrando a sua utilidade para obter maior eficiência e economia na análise. Made available in DSpace on 2021-04-23T12:34:14Z (GMT). No. of bitstreams: 1 Marcelo-Lazzarotto-Metodo-de-Folin.pdf: 534522 bytes, checksum: 8c266ba044c4d5166c536936dac6665a (MD5) Previous issue date: 2020

Sanofi; Bayer HealthCare Pharmaceuticals

This document reports on the test, installation and configuration of the components of the SPIDER Control Room.

This document reports the as-built design of the SPIDER Control rooms.

This document is intended as the Manufacturing Design required in Task Order #03 of F4E-OFC-280 Framework Contract for the part related to the Surveillance Camera System (OPTION #03) to be installed in the NBTF buildings.

This document contains the operation and maintenance manuals of the SPIDER Control room.

This report describes the activities carried out within the subtask T5.7 of the Work Programme WP2019 at the High Voltage Padova Test Facility HVPTF and on the new High Voltage Short Gap Test Facility HVSGTF. The activities mainly consisted in: 1) Test of two electrodes with double-polarity configurations (Common Mode Voltage tests). 2) Test of electropolished electrodes 3) Tests with cathode covered by a thick alumina cap 4) Removal of dust deposited inside the vacuum vessel before starting the vacuum system: 5) Tests with specific shaped electrodes designed to understand the effect of the mutual exchange of charged particles between electrodes are still in progress 6) Tests of Non Evaporable Getter (NEG) pumps at high voltage in high vacuum are still in progress 7) Ordinary Maintenance of the vacuum pump system 8) Tests in HVSGTF to measure the Fowler-Nordheim emission current from stainless steel electrodes. The activities mentioned in points #5 and #6 are still in progress and will be completed next year. Concerning the other experiments, the main outcomes can be reported as follows: 1) CMV tests showed that the main microdischarge activity of the electrodes appears to be related to phenomena involving only a single power supply unit and the vacuum chamber, rather than the two electrodes under test 2) Test of electropolished electrodes, tests with cathode covered by a thick alumina cap and Removal of dust deposited inside the vacuum vessel did not indicate significant improvements of voltage holding 3) The measurement of the Fowler-Nordheim emission current from stainless steel electrodes showed a behaviour much more complex than expected and their analysis is in progress.

The MITICA Central Safety System (MITICA CSS) implements a set of important protection functions related to personnel health and safety, both during and outside the operation of the MITICA test bed, providing continuous monitoring of potentially dangerous events, automated protection actions, and logging of events and data relevant for safety of people. The Technical Specification for the call for tender of the supply of the MITICA CSS was drafted in 2017 (ref. RFX_MITICA_TS_041), but some important details were still to be defined, also depending on the status of the procurement of plant systems interfacing with MITICA CSS and according to the experience acquired with SPIDER CSS installation. This document is intended to be the report of the main activities related to MITICA safety carried out in 2019, in order to better define the aspects needed to pass from the MITICA CSS "Draft" to the "Detailed" Techinical Specification.

This document is intended as the Manufacturing Design required in Task Order #03of F4E-OFC-280 Framework Contract for the part related to radioprotection instrumentation(OPTION #02)installed in NBTF buildings.

In questo rapporto tecnico si evidenziano brevemente - senza scendere troppo in particolari tecnici - i vantaggi ottenuti con il nuovo cluster di server l inux per il High Performance Co mputing che è stato realizzato nell'arco degli ultimi 24 mesi al Consorzio RFX. Il sistema è risultato necessario - quando non indispensabile - per la progettazione e la soluzione di problemi scientifici relativi ai progetti RFX - MOD2, SPIDER, MITICA e DTT. Il progetto ha coinvolto tutto il personale del Servizio Information Technology del Consorzio RFX: in particolare, sono state necessarie le competenze nella progettazione dei sistemi e della rete, nella messa a punto di soluzioni inn ovative, nell'installazione delle applicazioni sui server e su tutti i pc dei ricercatori del Consorzio e nella implementazione del backup dei dati.

This report describes the main activities carried out at the High Voltage Padova Test Facility HVPTF in 2018 and the ones related to the installation of a new high voltage test stand at the Consorzio RFX . The activities of the subtask 5.7 have been carried out according with the Work Programme (WP) 2018 between F4E and the Consorzio RFX, agreement on the Neutral Beam Test Facility. The activities mainly consisted in: ? studying of the X-ray spectra to investigate the nature of the physical phenomena which occurs during the high voltage conditioning ? testing instrumentation for precise current measurements and for determining type and position of discharges (visible imaging, IR imaging, RX spectra and Residual Gas Analyzer) ? maintenance of both positive and negative HV power supplies and the refurbishment of high voltage ceramic feedthroughs ? evaluation of other methods for improving voltage holding capabilities: tests of surface treatments on electrodes (e.g. alumina spray) ? testing the behaviour of "transparent anodes", i.e. anodes in which the surface is screened by a thin metallic mesh, aimed at zeroing the electric field at surface behind ? experimental study of two-electrode configurations subjected to a combination of Common-Mode Voltage (CMV) and differential-mode voltage to understand the different contribution of anode and cathode on the discharge initiation ? ordinary maintenance of the vacuum plant and controlling system ? construction of a small experimental set-up to measure with sufficient accuracy the FN emission insulating the electrodes by short vacuum gaps, the experimental set up has been called High Voltage Short Gap Test Facility (HVSGTF) The activity mentioned at the last point is partially reported in sec. 10. The specific technical note T5.7 - P1.4_RFX-IE-TN-59 has been prepared to indicate the data for the radiological safety assessment of the HVSGTF.