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10 results on '"Carrascosa, Lucia Campos"'

1. Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance

Author

Liu, Jiaye, Li, Pengfei, Wang, Ling, Li, Meng, Ge, Zhouhong, Noordam, Lisanne, Lieshout, Ruby, Verstegen, Monique M.A., Ma, Buyun, Su, Junhong, Yang, Qin, Zhang, Ruyi, Zhou, Guoying, Carrascosa, Lucia Campos, Sprengers, Dave, IJzermans, Jan N.M., Smits, Ron, Kwekkeboom, Jaap, van der Laan, Luc J.W., Peppelenbosch, Maikel P., Pan, Qiuwei, and Cao, Wanlu

Published
2021
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3. The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

Author

Luu, Maik, Pautz, Sabine, Kohl, Vanessa, Singh, Rajeev, Romero, Rossana, Lucas, Sébastien, Hofmann, Jörg, Raifer, Hartmann, Vachharajani, Niyati, Carrascosa, Lucia Campos, Lamp, Boris, Nist, Andrea, Stiewe, Thorsten, Shaul, Yoav, Adhikary, Till, Zaiss, Mario M., Lauth, Matthias, Steinhoff, Ulrich, and Visekruna, Alexander

Published
2019
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4. An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity

Author

Xu, Yuanming, primary, Carrascosa, Lucia Campos, additional, Yeung, Yik Andy, additional, Chu, Matthew Ling-Hon, additional, Yang, Wenjing, additional, Djuretic, Ivana, additional, Pappas, Danielle C., additional, Zeytounian, John, additional, Ge, Zhouhong, additional, de Ruiter, Valeska, additional, Starbeck-Miller, Gabriel R., additional, Patterson, James, additional, Rigas, Diamanda, additional, Chen, Shih-Hsun, additional, Kraynov, Eugenia, additional, Boor, Patrick P., additional, Noordam, Lisanne, additional, Doukas, Michael, additional, Tsao, Dave, additional, Ijzermans, Jan N., additional, Guo, Jie, additional, Grünhagen, Dirk J., additional, Erdmann, Joris, additional, Verheij, Joanne, additional, van Royen, Martin E., additional, Doornebosch, Pascal G., additional, Feldman, Renny, additional, Park, Terrence, additional, Mahmoudi, Salah, additional, Dorywalska, Magdalena, additional, Ni, Irene, additional, Chin, Sherman M., additional, Mistry, Tina, additional, Mosyak, Lidia, additional, Lin, Laura, additional, Ching, Keith A., additional, Lindquist, Kevin C., additional, Ji, Changhua, additional, Londono, Luz Marina, additional, Kuang, Bing, additional, Rickert, Robert, additional, Kwekkeboom, Jaap, additional, Sprengers, Dave, additional, Huang, Tzu-Hsuan, additional, and Chaparro-Riggers, Javier, additional

Published
2021
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5. Expression of cancer testis antigens in tumor-adjacent normal liver is associated with post-resection recurrence of hepatocellular carcinoma

Author

Noordam, Lisanne, Ge, Zhouhong, Özturk, Hadiye, Doukas, Michail, Mancham, Shanta, Boor, Patrick P.C., Carrascosa, Lucia Campos, Zhou, Guoying, van den Bosch, Thierry P.P., Pan, Qiuwei, Ijzermans, Jan N.M., Bruno, Marco J., Sprengers, Dave, Kwekkeboom, Jaap, Noordam, Lisanne, Ge, Zhouhong, Özturk, Hadiye, Doukas, Michail, Mancham, Shanta, Boor, Patrick P.C., Carrascosa, Lucia Campos, Zhou, Guoying, van den Bosch, Thierry P.P., Pan, Qiuwei, Ijzermans, Jan N.M., Bruno, Marco J., Sprengers, Dave, and Kwekkeboom, Jaap

Abstract

High recurrence rates after resection of hepatocellular carcinoma (HCC) with curative intent impair clinical outcomes of HCC. Cancer/testis antigens (CTAs) are suitable targets for cancer immunotherapy if selectively expressed in tumor cells. The aims were to identify CTAs that are frequently and selectively expressed in HCC-tumors, and to investigate whether CTAs could serve as biomarkers for occult metastasis. Tumor and paired tumor-free liver (TFL) tissues of HCC-patients and healthy tissues were assessed for mRNA expression of 49 CTAs by RT-qPCR and protein expression of five CTAs by immunohistochemistry. Twelve CTA-mRNAs were expressed in ≥10% of HCC-tumors and not in healthy tissues except testis. In tumors, mRNA and protein of ≥ 1 CTA was expressed in 78% and 71% of HCC-patients, respectively. In TFL, CTA mRNA and protein was found in 45% and 30% of HCC-patients, respectively. Interestingly, CTA-expression in TFL was an independent negative prognostic factor for post-resection HCC-recurrence and survival. We established a panel of 12 testis-restricted CTAs expressed in tumors of most HCC-patients. The increased risk of HCC-recurrence in patients with CTA expression in TFL, suggests that CTA-expressing (pre-)malignant cells may be a source of HCC-recurrence, reflecting the relevance of targeting these to prevent HCC-recurrence.

Published
2021

6. Targeting Gitr Enhances Human Tumour-infiltrating T Cell Functionality in Mismatch Repair Proficient Primary Colorectal Carcinoma and Liver Metastases

Author

Rakke, Yannick, Carrascosa, Lucia Campos, van Beek, Adriaan, de Ruiter, Valeska, Doukas, Michael, ter Borg, Susan, Doornebosch, Pascal, Vermaas, Maarten, van der Harst, Erwin, Coene, Peter Paul, Grunhagen, Dirk, Verhoef, Cornelis, IJzermans, Jan, Sprengers, Dave, Kwekkeboom, Jaap, Surgery, Gastroenterology & Hepatology, Internal Medicine, and Pathology

Published
2020

7. 588 Targeting GITR enhances human tumour-infiltrating T cell functionality in mismatch repair proficient primary colorectal carcinoma and liver metastases

Author

Rakké, Yannick, primary, Carrascosa, Lucia Campos, additional, Beek, Adriaan van, additional, Ruiter, Valeska de, additional, Doukas, Michael, additional, Borg, Susan ter, additional, Doornebosch, Pascal, additional, Vermaas, Maarten, additional, Harst, Erwin van der, additional, Coene, Peter Paul, additional, Grünhagen, Dirk, additional, Verhoef, Cornelis, additional, IJzermans, Jan, additional, Sprengers, Dave, additional, and Kwekkeboom, Jaap, additional

Published
2020
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8. TIGIT and PD1 dual checkpoint blockade restores functionality of tumor-infiltrating T cells in hepatocellular carcinoma

Author

Ge, Zhouhong, primary, Zhou, Guoying, additional, Carrascosa, Lucia Campos, additional, Gausvik, Erik, additional, Boor, Patrick, additional, Noordam, Lisanne, additional, Pan, Qiuwei, additional, Verheij, Joanne, additional, Erdmann, Joris, additional, Doukas, Michael, additional, IJzermans, Jan, additional, Kraan, Jaco, additional, Peppelenbosch, Maikel, additional, Kwekkeboom, Jaap, additional, and Sprengers, Dave, additional

Published
2020
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9. Expression of Cancer testis Antigens in Tumor-adjacent Normal Liver Predicts Post-resection Recurrence of Hepatocellular Carcinoma

Author

Noordam, Lisanne, primary, Ge, Zhouhong, additional, Özturk, Hadiye, additional, Doukas, Michail, additional, Mancham, Shanta, additional, Boor, Patrick P.C., additional, Carrascosa, Lucia Campos, additional, Zhou, Guoying, additional, Bosch, Thierry P.P. van den, additional, Pan, Qiuwei, additional, IJzermans, Jan N.M., additional, Bruno, Marco J., additional, Sprengers, Dave, additional, and Kwekkeboom, Jaap, additional

Published
2020
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