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564 results on '"Carrilho, Flair José"'

2. Contrast phase recognition in liver computer tomography using deep learning

Author

Rocha, Bruno Aragão, Ferreira, Lorena Carneiro, Vianna, Luis Gustavo Rocha, Ferreira, Luma Gallacio Gomes, Ciconelle, Ana Claudia Martins, Da Silva Noronha, Alex, Cortez Filho, João Martins, Nogueira, Lucas Salume Lima, Leite, Jean Michel Rocha Sampaio, da Silva Filho, Maurício Ricardo Moreira, da Costa Leite, Claudia, de Maria Felix, Marcelo, Gutierrez, Marco Antônio, Nomura, Cesar Higa, Cerri, Giovanni Guido, Carrilho, Flair José, and Ono, Suzane Kioko

Published
2022
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6. HCC in Patients with NAFLD/NASH

Author

Stefano, Jose Tadeu, de Mello Malta, Fernanda, de Campos, Priscila Brizola, Andrade, Pedro Fernandes, Paranaguá-Vezzozo, Denise Cerqueira, Carrilho, Flair Jose, Oliveira, Claudia P., and Romero-Gomez, Manuel, editor

Published
2020
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10. Diagnostic performance of three non-invasive fibrosis scores (Hepamet, FIB-4, NAFLD fibrosis score) in NAFLD patients from a mixed Latin American population

Author

Zambrano-Huailla, Rommel, Guedes, Laura, Stefano, Jose Tadeu, de Souza, Arthur A. Arrais, Marciano, Sebastián, Yvamoto, Erika, Michalczuk, Matheus Truccolo, Vanni, Denise Siqueira, Rodriguez, Hernan, Carrilho, Flair Jose, Alvares-da-Silva, Mario Reis, Gadano, Adrian, Arrese, Marco, Miranda, Adelina Lozano, and Oliveira, Claudia P.

Published
2020
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13. Lysosomal Acid Lipase Deficiency in the Etiological Investigation of Cryptogenic Liver Disease in Adults: A Multicenter Brazilian Study

Author

Candolo, Aline Coelho Rocha, primary, Cançado, Guilherme Grossi Lopes, additional, Zitelli, Patricia Momoyo, additional, Mazo, Daniel Ferraz de Campos, additional, Oliveira, Claudia Pinto Marques, additional, Cunha-Silva, Marlone, additional, Greca, Raquel Dias, additional, Araújo, Roberta Chaves, additional, Alustau, Amanda Sacha Paulino Tolentino, additional, Couto, Claudia Alves, additional, Nardelli, Mateus Jorge, additional, de Lima, Roque Gabriel Rezende, additional, Farias, Alberto Queiroz, additional, Carrilho, Flair José, additional, and Pessôa, Mário Guimarães, additional

Published
2023
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15. P-89 ASSESSMENT OF HEPATIC FIBROSIS IN TYPE 2 DIABETIC PATIENTS: A CROSS SECTIONAL ANALYSIS

Author

Mincis Rodrigo, Altikes Renato Gama, Vanni Denise Siqueira, Rossi Da Maria Elizabeth, Zitteli Patrícia Momoyo, Carrilho Flair José, P. Oliveira Claudia, and Pessoa Mario Guimarães

Subjects
Specialties of internal medicine, RC581-951
Abstract

Introduction: Metabolic dysfunction associated fatty liver disease (MAFLD) was suggested recently as a more appropriate nomenclature to describe the liver disease associated with known metabolic dysfunction .Type 2 Diabetes is a risk factor for MAFLD, steatohepatitis and patients are at increased risk to developing liver fibrosis and need to be more investigated. Aim: To investigate which MAFLD patients with type 2 diabetes have higher risk for advanced fibrosis. Methods: Patients in diabetes clinic, without known hepatic diseases and without significant alcohol intake (< 21 drinks per week), were voluntarily selected to perform liver ultrasound, liver stiffness and CAP measurements using Fibroscan (Echosens, Paris, France) and serological tests for B and C hepatitis to exclude viral causes of liver disease. Subjects were submitted to a complete clinical examination and laboratory tests. Results: 90 patients were included in this cross-sectional analysis. Overall, 12,2% (11 patients) had advanced fibrosis (liver stiffness > 8,7 Kpa) and 23% (21 patients) had severe steatosis (Grade 3 steatosis; CAP> 290 db/m) based on transient elastography. Factors associated with significant fibrosis were age over 60 years old, alanine amino transferase (ALT) elevation, low HDL (lower than 40), triglycerides elevation, higher BMI and severe steatosis. Conclusion: Prevalence of advanced fibrosis and severe steatosis in patients with type 2 diabetes and MAFLD is very high (12,2% and 23% respectively), what makes screening of these high-risk patients very important. Risk factors such as elevated glycated hemoglobin, higher BMI, triglycerides, ALT and CAP measurements on Fibroscan and low HDL indices are considered to be associated to advanced liver fibrosis.

Published
2021
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17. Cryptogenic chronic hepatitis: looking for an ideal diagnostic algorithm

Author

Cançado, Guilherme Grossi Lopes, primary, Candolo, Aline Coelho Rocha, additional, Nardelli, Mateus Jorge, additional, Zitelli, Patricia Momoyo, additional, Mazo, Daniel Ferraz de Campos, additional, Oliveira, Claudia Pinto, additional, Cunha-Silva, Marlone, additional, Greca, Raquel Dias, additional, Araújo, Roberta Chaves, additional, Alustau, Amanda Sacha Paulino Tolentino, additional, Couto, Cláudia Alves, additional, Roque, Gabriel Rezende de Lima, additional, Farias, Alberto Queiroz, additional, Carrilho, Flair José, additional, and Pessôa, Mário Guimarães, additional

Published
2023
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20. P-38 CRYPTOGENIC CHRONIC HEPATITIS: LOOKING FOR AN ETIOLOGICAL DIAGNOSIS

Author

Lopes, Guilherme Cançado Grossi, primary, Rocha, Aline Candolo Coelho, additional, Mateus, Jorge Nardelli, additional, Momoyo, Patricia Zitelli, additional, De Campos, Daniel Mazo Ferraz, additional, De Souza, Claudia Oliveira Pinto Marques, additional, Cunha-Silva, Marlone, additional, Dias, Raquel Greca, additional, Chaves, Roberta Araújo, additional, Tolentino, Amanda Sacha Alustau Paulino, additional, Alves, Claudia Couto, additional, De Lima, Roque Gabriel Rezende, additional, Queiroz, Alberto Farias, additional, Carrilho, Flair José, additional, and Pessôa, Mário Guimarães, additional

Published
2023
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22. P-42 OBESITY AND ANTI-HBC IGG POSITIVITY INCREASE THE RISK OF HEPATOCELLULAR CARCINOMA IN A COHORT OF CHRONIC HEPATITIS C PATIENTS IN A TERTIARY OUTPATIENT CLINIC IN SÃO PAULO, BRAZIL

Author

Trazzi, Alexandre, primary, Zitelli, Patricia Momoyo, additional, Ferraz, Daniel Mazo, additional, Rezende, Roque Gabriel, additional, Pinto, Claudia Oliveira, additional, Lopes, Aline Chagas, additional, Carrilho, Flair José, additional, and Pessoa, Mário Guimarães, additional

Published
2023
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26. A randomized crossover trial to assess therapeutic efficacy and cost reduction of acid ursodeoxycholic manufactured by the university hospital for the treatment of primary biliary cholangitis

Author

Nakano, Larissa Akeme, Cançado, Eduardo Luiz Rachid, Chaves, Cleuber Esteves, Madeira, Maria Cristina Vaz, Katayose, Jéssica Toshie, Nabeshima, Mariana Akemi, Fossaluza, Victor, Uhrigshardt, Gabriela Guimarães, Liting, Zheng, Pinto, Vanusa Barbosa, Carrilho, Flair José, and Ono, Suzane Kioko

Published
2020
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30. NAFLD in Polycystic Ovary Syndrome: Association with PNPLA3 and Metabolic Features

Author

Recuero, Amanda Medeiros, primary, Gomes, Larissa Garcia, additional, Maciel, Gustavo Arantes Rosa, additional, de Mello Malta, Fernanda, additional, Salles, Ana Paula Moreira, additional, Vezozzo, Denise Cerqueira Paranaguá, additional, Baracat, Edmund Chada, additional, Pinho, João Renato Rebello, additional, Carrilho, Flair José, additional, Stefano, José Tadeu, additional, and Oliveira, Claudia P., additional

Published
2022
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32. Two decades of liver resection with a multidisciplinary approach in a single institution: What has changed? Analysis of 1409 cases

Author

Herman, Paulo, Fonseca, Gilton Marques, Coelho, Fabricio Ferreira, Kruger, Jaime Arthur Pirola, Makdissi, Fabio Ferrari, Jeismann, Vagner Birk, Carrilho, Flair José, D’Albuquerque, Luiz Augusto Carneiro, and Nahas, Sergio Carlos

Subjects
Colorectal liver metastases, Liver neoplasms, Hepatocellular carcinoma, Hepatectomy, Morbidity
Abstract

Objectives: To evaluate results of patients undergoing liver resection in a single center over the past two decades with a particular look at Colorectal Liver Metastasis (CRLM) and Hepatocellular Carcinoma (HCC). Method: Patients were divided into two eras, from 2000 to 2010 (Era 1) and 2011 to 2020 (Era 2). The most frequent diagnosis was CRLM and HCC, with 738 (52.4%) and 227 (16.1%) cases respectively. An evaluation of all liver resection cases and a subgroup analysis of both CRLM and HCC were performed. Preoperative and per operative variables and long-term outcomes were evaluated. Results: 1409 liver resections were performed. In Era 2 the authors observed higher BMI, more: minimally invasive surgeries, Pringle maneuvers, and minor liver resections; and less transfusion, less ICU necessity, and shorter length of hospital stay. Severe complications were observed in 14.7% of patients, and 90-day mortality was 4.2%. Morbidity and mortality between eras were not different. From 738 CRLM resections, in Era 2 there were significantly more patients submitted to neoadjuvant chemotherapy, bilateral metastases, and smaller sizes with significantly less transfusion, the necessity of ICU, and shorter length of hospital stay. More pedicle clamping, minimally invasive surgeries, and minor resections were also observed. From 227 HCC resections, in Era 2 significantly more minimally invasive surgeries, fewer transfusions, less necessity of ICU, and shorter length of hospital stay were observed. OS was not different between eras for CRLM and HCC. Conclusions: Surgical resection in a multidisciplinary environment remains the cornerstone for the curative treatment of primary and metastatic liver tumors.

Published
2022

34. Outcome of liver cancer patients with SARS-CoV-2 infection

Author

Muñoz-Martínez, Sergio, Sapena, Victor, Forner, Alejandro, Bruix, Jordi, Sanduzzi-Zamparelli, Marco, Ríos, José, Bouattour, Mohamed, El Kassas, Mohamed, Leal, Cassia Regina Guedes, Mocan, Tudor, Nault, Jean-Charles, Alves, Rogerio Camargo Pinheiro, Reeves, Helen L, da Fonseca, Leonardo, García-Juárez, Ignacio, Pinato, David J, Varela, María, Alqahtani, Saleh A, Alvares-da-Silva, Mario Reis, Bandi, Juan C, Rimassa, Lorenza, Lozano, Mar, González Santiago, Jesús Manuel, Tacke, Frank, Sala, Margarita, Anders, María, Lachenmayer, Anja, Piñero, Federico, França, Alex, Guarino, Maria, Elvevi, Alessandra, Cabibbo, Giuseppe, Peck-Radosavljevic, Markus, Rojas, Ángela, Vergara, Mercedes, Braconi, Chiara, Pascual, Sonia, Perelló, Christie, Mello, Vivianne, Rodríguez-Lope, Carlos, Acevedo, Juan, Villani, Rosanna, Hollande, Clemence, Vilgrain, Valérie, Tawheed, Ahmed, Ferguson Theodoro, Carmem, Sparchez, Zeno, Blaise, Lorraine, Viera-Alves, Daniele Evaristo, Watson, Robyn, Carrilho, Flair José, Moctezuma-Velázquez, Carlos, D'Alessio, Antonio, Iavarone, Massimo, and Reig, Maria

Subjects
610 Medicine & health
Abstract

BACKGROUND & AIMS Information about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with liver cancer is lacking. This study characterizes the outcomes and mortality risk in this population. METHODS Multicenter retrospective, cross-sectional, international study of liver cancer patients with SARS-CoV-2 infection registered between February-December 2020. Clinical data at SARS-CoV-2 diagnosis and outcomes were registered. RESULTS Two-hundred-fifty patients from 38 centers were included, 218 with hepatocellular carcinoma (HCC), 32 with intrahepatic cholangiocarcinoma (iCCA). Median age was 66.5 and 64.5 years, and 84.9% and 21.9% had cirrhosis in the HCC and iCCA cohorts, respectively. Patients had advanced cancer stage at SARS-CoV-2 diagnosis in 39.0% of the HCC and 71.9% of the iCCA patients. After a median follow-up of 7.20 [IQR:1.84-11.24] months, 100 (40%) patients have died,48% of the deaths were SARS-CoV-2-related. Forty (18.4%) HCC patients died within 30-days. The death rate increase was significantly different according to the BCLC stage [6.10%(95%CI 2.24-12.74), 11.76%(95%CI 4.73-22.30), 20.69%(95%CI 11.35-31.96), and 34.52%(95%CI 17.03-52.78) for BCLC 0/A, B, C and D respectively; p=0.0017]. The Hazard Ratio was 1.45 (95%CI 0.49-4.31; p=0.5032) in BCLC-B vs 0/A, and 3.13 (95%CI 1.29-7.62; p=0.0118) in BCLC-C vs 0/A in the Competing risk Cox regression model. Nineteen out of 32 iCCA (59.4%) died, 12 deaths related to SARS-CoV-2 infection. CONCLUSIONS This is the largest cohort of liver cancer patients infected with SARS-CoV-2. It characterizes the 30-day mortality risk of SARS-CoV-2 infected patients with HCC during this period.

Published
2022

38. THU-057-YI Distinguishing clinical profiles in acute-on-chronic liver failure: a comparative analysis of alcohol-related hepatitis versus infection precipitated acute-on-chronic liver failure

Author

Pohl, Julian, Kerbert, Annarein, de la Peña-Ramirez, Carlos, Walia, Nirbaanjot, Sanchez, Cristina, Kumar, Pavitra, Zhang, Ingrid Wei, Rausch, Lilli, Sittner, Richard, Papp, Maria, Caraceni, Paolo, Alessandria, Carlo, Laleman, Wim, Albillos, Agustín, Janicko, Martin, Vargas Blasco, Víctor Manuel, Mookerjee, Rajeshwar Prosad, Farias, Alberto, Pereira, Gustavo, Torre, Aldo, Marciano, Sebastián, Mattos, Angelo Z., Carrilho, Flair Jose, Arroyo, Vicente, Trebicka, Jonel, Moreau, Richard, Clària, Joan, Angeli, Paolo, Piano, Salvatore, Gustot, Thierry, Andreola, Fausto, Jalan, Rajiv, and Engelmann, Cornelius

Published
2024
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39. THU-050 Urinary biomarkers of tubular and glomerular damage predict renal recovery in patients with hepatorenal syndrome-acute kidney injury

Author

Piano, Salvatore, Dall'Acqua, Stefano, de la Peña-Ramirez, Carlos, Sanchez, Cristina, Aguilar, Ferran, Zilio, Gianluca, Brocca, Alessandra, Farias, Alberto, Papp, Maria, Pereira, Gustavo, Caraceni, Paolo, Torre, Aldo, Alessandria, Carlo, Gadano, Adrian, Laleman, Wim, Mattos, Angelo Z., Uschner, Frank Erhard, Albillos, Agustín, Bañares, Rafael, Janicko, Martin, Vargas Blasco, Víctor Manuel, Mookerjee, Rajeshwar Prosad, Fernández, Javier, Gustot, Thierry, Jalan, Rajiv, Clària, Joan, Moreau, Richard, Arroyo, Vicente, Carrilho, Flair Jose, Trebicka, Jonel, and Angeli, Paolo

Published
2024
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40. LBP-012 Epidemiological trends and clinical impact of multidrug-resistant bacterial infections in patients with cirrhosis across Latin America: results from the ACLARA study

Author

Diaz, Juan Manuel, Farias, Alberto, Uson, Eva, Zitelli, Patricia Momoyo, Pereira, Gustavo, Goncalves, Luciana Lofego, Torre, Aldo, Gadano, Adrian, Mattos, Angelo Z., Alvares-da-Silva, Mario, Costa Mendes, Liliana Sampaio, Bittencourt, Paulo, Benitez, Carlos, Couto, Claudia Alves, Mendizabal, Manuel, Toledo, Claudio, Mazo, Daniel, Castillo, Mauricio, Martín, Padilla Machaca, Lyra, André Castro, Lozano, Adelina, Velazquez, René Malé, Davalos, Milagros, Pérez-Hernández, José Luis, Rafael, Oliveira Ximenes, Giovanni, Faria Silva, Beltran, Oscar, González-Huezo, Maria Sarai, Bessone, Fernando, da Rocha Tarciso Daniel, dos Santos, Fassio, Eduardo, Carlos, Terra, Marín Zuluaga, Juan Ignacio, Sierra, Patricia, de la Peña-Ramirez, Carlos, Aguilar, Ferran, Fernanda, Fernandes Souza, Maria da Penha, Zago Gomes, Marciano, Sebastián, Osvely, Mendez, Codes, Liana, Arrese, Marco, de Alcanatara Barreto, Camila Marques, Sanchez, Cristina, Trebicka, Jonel, Gustot, Thierry, Claria, Joan, Jalan, Rajiv, Angeli, Paolo, Arroyo, Vicente, Carrilho, Flair Jose, Moreau, Richard, and Fernandez, Javier

Published
2024
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41. Liver elastography can predict degree of advanced fibrosis for autoimmune hepatitis in biochemical remission.

Author

Paranaguá‐Vezozzo, Denise Cerqueira, Benedita Terrabuio, Débora Raquel, Reinoso‐Pereira, Gleicy Luz, Moutinho, Renata, Kioko Ono, Suzane, Walwyn Salas, Veronica, Dias França, Joao Italo, Alves, Venâncio Avancini Ferreira, Cançado, Eduardo Luiz Rachid, and Carrilho, Flair José

Subjects
AUTOIMMUNE hepatitis, HEPATIC fibrosis, RECEIVER operating characteristic curves, LIVER biopsy, ELASTOGRAPHY
Abstract

Background and Aim: The aim was to analyze the concordance of liver stiffness measurement (LSM) either by transient elastography (TE) or ARFI with liver biopsy in autoimmune hepatitis (AIH) patients with biochemical remission and to identify those with histological remission. Liver biopsy is still the golden standard for AIH diagnosis. However, it is an invasive procedure and these patients, most of the time, require many biopsies, so it would be valuable to search for noninvasive method that could select all these patients and keep under observation. Methods: Thirty‐three patients with AIH were submitted for liver biopsy to evaluate histological remission after at least 18 months of normal aminotransferases. The efficiency of LSM and fibrosis stages was tested by a receiver operating characteristic curve analysis (AUROC). Results: One patient (3%) was F0, 6 (18.2%) were F1, 8 (24.2%) were F2, 10 (30.3%) were F3, and 8 (24.2%) were F4, according to METAVIR. Thirteen of thirty‐three (39.4%) patients did not achieve histological remission. AUROC for F4 stage was 0.83 (IC: 0.76–0.99) for TE and 0.78 (IC: 0.65–0.95) for ARFI. Optimal LSM cutoff values were 12.3 kPa (Se = 87.5%, Sp = 88%) for TE and 1.65 m/s (Se = 87.5%, Sp = 76%) for ARFI. The tests were unable to differentiate patients with histological activity from those in histological remission (P < 0.05). Conclusion: TE and ARFI accurately identify liver fibrosis by METAVIR score in AIH patients with biochemical remission. No cutoff value was detected to indicate whether the patient achieved histological remission. [ABSTRACT FROM AUTHOR]

Published
2023
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