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619 results on '"Carroll, F. I."'

9. Base-catalyzed C-2 exchange and epimerization of cocaine analogs: methyl 3-beta-substituted 8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylates

Author

Casale, John F., Lewin, Anita H., Bowen, J. Phillip, and Carroll, F. I.

Subjects
Chemical reaction, Rate of -- Research, Cocaine -- Research, Biological sciences, Chemistry
Abstract

Deuterium incorporation, epimerization and molecular modeling studies were conducted on epimeric methyl 3-beta-substituted 8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylates to determine the compounds' kinetic and thermodynamic properties. Results showed that the compounds featured higher C-2 deprotonation rate from the alpha-face than from the beta-face resulting in more stable 2-alpha-epimeric structures. Moreover, the thermodynamics and kinetics of the compounds facilitated the formation of the pseudoisomer.

Published
1992

10. Formulation and Characterization of Conjugate Vaccines to Reduce Opioid Use Disorders Suitable for Pharmaceutical Manufacturing and Clinical Evaluation

Author

Baruffaldi, F., primary, Raleigh, M. D., additional, King, S. J., additional, Roslawski, M. J., additional, Birnbaum, A. K., additional, Hassler, C., additional, Carroll, F. I., additional, Runyon, S. P., additional, Winston, S., additional, Pentel, P. R., additional, and Pravetoni, M., additional

Published
2019
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15. Effect of nicotine and alpha-7 nicotinic modulators on visceral pain-induced conditioned place aversion in mice.

Author

Bagdas, D., Meade, J. A., Alkhlaif, Y., Muldoon, P. P., Carroll, F. I., and Damaj, M. I.

Abstract

Background: Preclinical assays of affective and sensorial aspects of nociception play a key role in research on both the neurobiology of pain and the development of novel analgesics. Therefore, we investigated the effects of nicotine and alpha-7 nicotinic acetylcholine receptor (nAChR) modulators in the negative affective and sensory components of visceral pain in mice.Methods and Results: Intraperitoneal acetic acid (AA) administration resulted in a robust stretching behaviour and conditioned place aversion (CPA) in mice. We observed a dose-dependent reduction in AA-induced stretching and CPA by the nonselective nAChRs agonist nicotine. Mecamylamine, a nonselective nAChRs agonist, was able to block its effects; however, hexamethonium, a peripherally restricted nonselective nicotinic antagonist, was able to block nicotine's effect on stretching behaviour but not on CPA. In addition, systemic administration of α7 nAChR full agonists PHA543613 and PNU282987 was failed to block stretching and CPA behaviour induced by AA. However, the α7 nAChR-positive allosteric modulator PNU120596 blocked AA-induced CPA in a dose-dependent manner without reducing stretching behaviours.Conclusions: Our data revealed that while nonselective nAChR activation induces antinociceptive properties on the sensorial and affective signs of visceral pain in mice, α7 nAChRS activation has no effect on these responses. In addition, nonselective nAChR activation-induced antinociceptive effect on stretching behaviour was mediated by central and peripheral mechanisms. However, the effect of nonselective nAChR activation on CPA was mediated centrally. Furthermore, our data suggest a pivotal role of allosteric modulation of α7 nAChRS in the negative affective, but not sensory, component of visceral pain.Significance: The present results suggest that allosteric modulation of α7 nAChR may provide new strategies in affective aspects of nociception. [ABSTRACT FROM AUTHOR]

Published
2018
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