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15. Irish thoracic society: Proceedings of annual scientific meeting held in Cork on 5th & 6th November, 1993

Author

Chan, K. H., Singh, H. P., Aherne, T., Carabine, U., Gilliland, H., Johnston, J. R., Lowry, K. G., McGuigan, J., Cosgrove, J., Veerasingham, D., McCarthy, J., Hurley, J., Wood, A. E., Gilliland, R., McGuigan, J. A., McManus, K. G., Wilkinson, P., Johnston, L. C., MacMahon, J., Wilson, D., Austin, C., Anikin, V., McManus, K., McGuigan, J., McManus, K., Anikin, V., Gibbons, J. R. P., McGuigan, J., Sharkey, R., Long, M., Maree, A., O’Neill, S., Maguire, C. P., Hayes, J. P., Masterson, J., Fitzgerald, M. X., Hayes, M., Maguire, C. P., Hayes, J. P., Masterson, J., Fitzgerald, M. X., Quigley, C., Mofidi, A., Mofidi, R., Fitzgerald, M. X., O’Neill, M., Watson, J. B. G., O’Halloran, E. T., Shortt, C., Taylor, M., Holland, C., O’Lorcain, P., Taylor, M., Holland, C., O’Lorcain, P., Pathmakanthan, S., Sreenan, S., Power, C. K., Poulter, L. W., Burke, C. M., Reilly, D., Pathmakanthan, S., Sreenan, S., Doyle, S., Burke, C. M., Sreenan, S., Power, C., Pathmakanthan, S., Goggin, A., Burke, C. M., Poulter, L. W., Sreenan, S., Doyle, S., Pathmakanthan, S., Poulter, L. W., Burke, C. M., Sreenan, S., Debenham, P., Pathmakanthan, S., Burke, C. M., Poulter, L. W., Southey, A., O’Connor, C. M., Fitzgerald, M. X., Bourke, W. J., McDonnell, T. J., Buck, J. B., Magee, T. R. A., Lowry, R. C., Graham, A. N. J., Owens, W. A., Kelly, S. B., McGuigan, J. A., Costelloe, R. W., Ryan, J., Collins, J., Guerin, D., Rooney, D., Long, E., O’Donnell, M., O’Neill, S., Cotter, T. P., Bredin, C. P., Buick, J. B., Lowry, R. C., MacMahon, J. J., Finlay, G., Concannon, D., McDonnell, T. J., Reid, P. T., Alderdice, J., Carson, J., Sinnamon, D. G., Murphy, S., Scott, T., Keane, C. T., Walsh, J. B., Coakley, D., McKeown, D., Kelly, P., Clancy, L., Kiely, J. L., Cryan, B., Bredin, C. P., Killeen, P., Farrell, S., Kelly, P., Clancy, L., Kiely, J. L., O’Riordan, D. M., Sheehan, S., Curtain, J., Hogan, J., Bredin, C. P., Malone, A., Ahmed, S., Watson, J. B. G., Murphy, M., Fennell, W., Ahmed, S., Watson, J. B. G., Aherne, T., Keohane, C., O’Neill, M., Gleeson, C. M., McGuigan, J., Ritchie, A. J., Russell, S. E. H., Molloy, E., Keane, M., Coakley, R., Costello, R., Condron, C., Watson, R. G. W., O’Neill, S., Kelly, C., Redmond, H., Watson, W., Burke, P., Bouchier-Hayes, D., Donnelly, S. C., Haslett, C., Dransfield, I., Robertson, C. E., Carter, D. C., Ross, J. A., Grant, I. S., Tedder, T. F., Doyle, S., Sreenan, S., Pathmakanthan, S., Burke, C. M., Heaney, L. G., Cross, L. J. M., Stanford, C. F., Ennis, Madeleine, Sreenan, S., Pathmakanthan, S., Power, C., Goggin, A., Poulter, L. W., Burke, C. M., Murphy, S., Scott, T., Keane, C. T., Walsh, J. B., Coakley, D., O’Riordan, D. M., Gergely, L., Deng, N., Rose, R. M., Hennessy, T., Hickey, L., Thornton, L., Collum, C., Durity, M., Power, J., Johnson, H., Lee, B., Doherty, E., Kelly, E., McDonnell, T., McKeown, D., Kelly, P., Clancy, L., Wilkinson, P., Varghese, G., Anikin, V., Gibbons, J., McManus, K., McGuigan, J., Reid, P. T., Gower, N. H., and Rudd, R. M.

Published
1994
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16. Irish thoracic society: Proceedings of Annual Meeting held in Galway on November 6th & 7th, 1992

Author

Quigley, C., Mofidi, R., Liu, G., O’Connor, C., FitzGerald, M. X., Johnson, H., MacDonnell, T., Lee, B., Kelly, E., Doherty, E., McCarthy, J. F., Hurley, J., Wood, A. E., Lynch, V. P., Ellias, E., Tahir, M., Asad Ali, S., Istarabadi, M., Hussain, R., McGovern, Ms. E., Luke, D. A., Murphy, M., Mealy, K., Little, D., Burke, P., O’Neill, S., Broe, P., Guidon, M., Long, M., Reid, P. T., MacMahon, J., Babu, M. V. S., Watson, J. B. G., O’Halloran, E. T., Kumar, P., Shortt, C., Murphy, S., Hegarty, V., Scott, T., Keane, C. T., Walsh, J. B., Coakley, D., Clancy, L., Corcoran, P., Kelly, P., Healy, T., Moore, H., Cormican, M., Flynn, J., Gilmartin, J. J., O’Connor, H., Power, W., McNicholas, N., Lindsay, P. J., Noone, D., Glennon, M., Smith, T., Gannon, F., O’Dwyer, R., Stack, N., Kyne, K., McHale, E., Sidhu, P., O’ Sullivan, R., Callaghan, J., Wilkinson, P., McKenzie, G., O’Connor, C. M., Ryan, M., Shanahan, P., O’Donnel, N., Conlon, P., O’Neill, G., Long, H., Carmody, M., Keogh, B., Donohoe, J., Walshe, J., Lyons, D. J., Madrigal, L., Luke, D., McKinley, R. K., Jamison, J. P., Sreenan, S. K., Power, C. K., Pathmakanthan, S., Burke, C. M., Poulter, L. W., O’Donovan, D. A., Bouchier-Hayes, D. M., Kelly, C., Grace, P., Redmond, H. P., Monkhouse, W. S., Bouchier-Hayes, D., Bourke, W. J., McDonnell, T. J., Cotter, T. P., Bredin, C. P., Hayes, J. P., Ward, K., Muldowney, F., Othman, S., Conroy, R., Collum, C., Durity, M., Power, J., Gaffney, K., Southey, A., Keane, J., Byrne, N., Hayes, J., Magee, T. R. A., Buick, J. B., Lowry, R. C., Kelly, C. J., Shou, J., Gallagher, H., Daly, J. M., Bouchier-Hayes, D, Donnelly, S. C., Haslett, C., Grant, I. S., Streiter, R. M., Kunkel, S. L., Walz, A., Robertson, C. R., Carter, D. C., Pollock, A. J., O’Neill, M., Dockrell, D., Rooney, M., Memon, I., Loftus, B. G., Mulcahy, R., Periappuram, Murphy, P., Mulroy, Sr. M., Taylor, M. R. H., Costello, R., McNicholas, W. T., Watson, R. G. W., and O’Neill, S. J.

Published
1993
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18. Irish Society of Gastroenterology: Proceedings of meeting held November 1990

Author

Coleman, J., Hayes, D. Bouchier, Daw, M. A., O’More, R., Keane, C. T., O’Morain, C., Johnson G. W., Spencer E. F. A., Wilkinson A. J., Kennedy T. L., Collins, J. S. A., Bamford, K. B., Collins, B. J., Sloan, J. M., Moorehead, R. J., Love, A. H. G., McCarthy, C., Collins, R., Beattie, S., McDevitt, J., Feighery, C., O’Farrelly, C., Weir, D. G., Kelleher, D., Whelan, A., Williams, Y., Kellegher, D., Weir, D., Prabhakar, M. C., Daw, M., Keane, F., McDermott E. W. M., Duduric B., Brennan M. F., Gaffney, R., O’Leary, J., Doyle, T., Gaffney, A., Gough, D. B., Fearon, K. C. H., Winstanley, P., Carter, D. C., McAnena, O. J., Moore, F. A., Moore, E. E., Pogetti, R., Peterson, V. M., Abemathy, C. M., Parsons, P., Williams, N. N., Daly, J. M., Herlyn, M., Bouchier-Hayes, D., Course, N. F., Horgan, P. G., Fahy, A., Delaney, C., Fitzpatrick, J. M., Gorey, T. F., Jazrawl S., Walsh T. N., Byrne P. J., Lawlor P., Hennessy T. P. J., O’Sullivan, K. R., Mathias, P. M., McNicholas, M., Logan, M., Masterson, J., Gillen, P., Hyland, J., Beausang, E., Joyce, W. P., Williams, N., Maxwell, W., Reid, I., Sharpe, I., Geraghty, J. G., Tanner, W. A., Patchett, S., Mulcahy, H., Afdhal, N., O’Donoghue, D., Lohan, A., Darzi, A., Keane, F. B. V., Keeling, P. W. N., Gibney, R. C., Keane, R., Drumm, J., Egan, T. J., Delaney, P. V., O’Sullivan, G., Harte, P., Grace, P. A., Qureshi, A., Osbome, H., Bouchier-Hayes, D. J., Bamford, S. L., Geraghty, J., Keane, F. B., Coleman, J. E., Gleeson, A., Mealy, K., Barry, M., Traynor, O., Keating, J. J., Chua, A., Ah-Kion, S., McNulty, J., Heaney, L. G., Murphy, P., Connolly, J. H., Callender, M. E., MacMathuna, P., Farrant, M., Hourihane, D. O. B., Donaldson, P., Lombard, M., Westaby, D., Weir, D. G., Williams, Roger, Couse, N. F., Burke, J., Lennon, G., Delaneyc, C. P., O’Brien, S., O’Brien, A., Fitzgerald, M. X., Hegarty, J. E., Noonan, N., Healy, M., O’Moore, R., Corrigan, O. I., Keating, P. W. N., Li, H. U. I., Byrne, P. J., Lawlor, P., Stuart, R. C., Jazrawi, S., Walsh, T. N., Hennessy, T. P. J., Course, N. F., Wai, D., Jaeger, H., Jackson, A. M., Mitchell, C. J., MacFie, J., Delaney, C. P., McGeeney, K., Caldwell, M. T. P., O’Donoghue, D. P., Connolly J., Stuart R. C., Kay E., Gorey T., Keane R., McKiernan, P., Glasgow, J. F. T., Johnson, B. T., Ferguson, R., Davidson, I., Hurley, J., Keeling, P., Crowley, T., Long, A. A., O’Brien, D. P., Waldron, R. P., Shearer, M. J., Given, H. F., McEntee, G., Monson, J., Donohue, J., Nagomey, D., Trimble, K. C., Molloy, A. M., Scott, J. M., Kay, E., McKeever, J., and Hennessey, T. P. J.

Published
1993
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20. Fifteenth Sir Peter Freyer Memorial Lecture and Surgical Symposium Proceedings of meeting held 14th & 15th September, 1990 at University College, Galway

Author

Bolger, C., Fry, G., Coakley, D., Philips, J., Sheahan, N., Malone, J., Gray, W. P., O’Sullivan, M., Buckley, T. F., O’Dwyer, T. P., Gullane, P. J., Kneafsey, B. P., Moran, K. T., O’Sullivan, S. T., Brady, M. P., Coveney, E. C., Geraghty, J. G., O’Higgins, N. J., O’Beirne, J., Seighe, P., McElwain, J. P., McCabe, J. P., Waldron, B., Byme, J., Waldron, B., Hickey, N., McCabe, J., McMahon, J., Colville, J., Moran, B. J., Frost, R. A., Kerin, M. J., Jaeger, J. J., Mitchell, C. J., MacFie, J., O’Hanrahan, T., Scott, N. A., Leinhardt, D., Irving, M. H., Gough, D., White, M., Morrin, M., Joyce, W., Phelan, D., Fitzpatrick, J., Gorey, T., Kerin, M. J., Wilkinson, D., Parkin, A., Kester, R. C., Gibney, E. J., McGrath, K., Cunningham, A. J., Bouchier-Hayes, D., Barry, M., Farrell, M., Monkhouse, W., Bouchier-Hayes, D., Dawson, K. J., Hehir, D., Hamilton, G., Grace, P. A., Quereschi, A., Keane, R., Broe, P., Bouchier-Hayes, D., Stansby, G., Hehir, D., Fuller, B., Hamilton, G., Connolly, A., O’Donnell, J., Little, D., Keane, R. M., Regan, M., Bouchier-Hayes, D., Horgan, P. G., Curran, C., O’Brien, D., Waldron, D., Mooney, E., Greally, J., Given, H. F., Duffy, M. J., Reilly, D., Coveney, E., Geraghty, J., Fennelly, J. J., O’Higgins, N., O’Hare, C. M., Jones, P. L., Zoma, T. A., Hemstreet, G. P., Postier, R. G., Coleman, J. E., Chaikof, E. L., Merrill, E. W., Callow, A. D., Williams, N. N., Daly, J. M., Herlyn, M., Bouchier-Hayes, D., Gaffney, R., Walsh, M., McShane, D., Timon, C., Hamilton, D., Connolly, J., Byrne, P. J., Stuart, R. B., Kay, E., Gorey, T., Hennessy, T. P. J., O’Leary, D. P., Booker, M., Scott, T. E., LaMorte, W. W., Geraty, J. G., Angerson, W. A., Carter, D. C., Lyons, J., Gough, D., Stack, A., Joyce, W., Gorey, T., Fitzpatrick, J. M., Kelly, C., Augustine, C., Kennedy, J., Creagh, T., Bouchier-Hayes, D., Mannion, D., Seigne, P., Fitzpatrick, G., Feeley, M., Butler, P., Grace, P., Leader, M., Curren, B., Barry-Walsh, C., Bouchier-Hayes, D., O’Brien, D., Horgan, P. G., Waldron, R., Shearer, M., Given, H. F., O’Rourke, S., Galea, M., Gilmour, A., Carter, R., Parkin, D., Blarney, R. W., Hehir, D. J., Parbhoo, S. P., Rothnie, N., Crowe, J., Wells, C., Dawson, K. J., Geraghty, J. G., Coveney, E. C., Duffy, M. J., Sherry, F., O’Higgins, N. J., Duffy, M. J., O’Grady, P., Coveney, E., Geraghty, J., Fennelly, J. J., O’Higgins, N. J., Byrne, J., Horgan, P. G., England, S., O’Callaghan, J., Given, H. F., Horgan, P. G., Waldron, D., O’Brien, D., Mooney, E., Grimes, H., Given, H. F., O’Brien, D., Horgan, P. G., Mooney, E., Waldron, D., Grimes, H., Given, H. F., Mulcahy, Ursula, Coveney, E. C., Smyth, P. P. A., McAlister, V., Geraghty, J. G., Murray, M. J., O’Higgins, M. J., Laoide, R. O., Coveney, E. C., Geraghty, J. G., Hourihane, J. B., O’Higgins, N. J., Mooney, E. F., Horgan, P. G., Brougham, C., Headon, D. R., Given, H. F., Coleman, C., Coveny, E. C., Laoide, R. O., Geraghty, J. G., Hourihane, J. B., O’Higgins, N. J., Jazawi, S., Walsh, T. N., Byrne, P. J., Lawlor, P., Li, H., Bolger, C., Sanfey, H., Hennessy, T. P. J., Joyce, W. P., Gough, D. B., Delaney, P. V., Gorey, T. F., Fitzpatrick, J. M., Attwood, S. E. A., Watson, A., Rogers, E., Waldron, R. P., Glynn, G., El-Bouri, K. U., Flynn, J., Keeling, P., Davies, M. G., Lavelle, J., Connolly, J., Shine, M. F., Lennon, F., Byrne, P. J., Stewart, R. C., Lawlor, P., Walsh, T. N., Hennessy, T. P., McKiernan, M. V., Johnston, J. G., Rogers, E., Greally, J., Hanrahan, L., Bredin, H. C., Corcoran, M. O., Norton, M., Rogers, E., Bredin, H. C., Corcoran, M. O., Flynn, R., Gleeson, M., Grainger, R., McDermott, T. E. D., Lanigan, D., McLean, P., Curran, B., Leader, M., Gleeson, M. J., Griffin, D. P., Gallagher, H. J., Creagh, T. A., Mulvin, D. M., Donovan, M. G., Murphy, D. M., McLean, P. A., Mulvin, D. W., Creagh, T. A., O’Brien, A., Murphy, D. M., O’Flynn, K. L., McDonagh, R., Thomas, D. G., Lynch, T. H., Anderson, P., Vaughan, A. T. M., Beaney, R. P., Wallace, D. M. A., Connolly, J., Solomon, L., Lavelle, J., Lennon, F., Shine, M. F., O’Riordain, D. S., O’Connell, P. R., Kirwan, W. O., Li, Hui, Byrne, P. J., Lawlor, P., Stuart, R. C., Jazrawi, S., Walsh, T. N., Hennessy, T. P. J., Koh, T. N., Sheehan, S. J., McKeever, J., Donohoe, J., Carmody, M., Osborne, D. H., Waldron, D. E., Rodgers, E., Patel, F., Horgan, P., Corcoran, M., Given, H. F., Walsh, K., Joyce, W. P., Gough, D. B., Gorey, T. F., Fitzpatrick, J. M., O’Donoghue, J. M., Waldron, R., Kerin, M. J., McCabe, J. P., McAnena, O. J., McGuire, M., Given, H. F., Smyth, J., Keye, G., Bahadursingh, A., Delaney, C., Joyce, W. P., Gough, D., Fitzpatrick, J. M., Gorey, T. F., Richie, A. J., Gibbons, J. R. P., O’Hanrahan, T., Marples, M., Banacewicz, J., Coleman, J. E., Troidl, H., Cassidy, L., Grace, P., Bouchier-Hayes, D., Prenderville, E. J., Burke, P. E., Colgan, M. -.P, Wee, B. L., Moore, D. J., Shanik, G. D., Cross, K. S., El-Sanadiki, M., Murray, J. J., Mikat, E., McCann, R., Hagen, P. -O., Cheatle, T. R., Steibe, E., Smith, P. D. Colebridge, Scurr, J. H., Barry, K., Waldron, D., Bresnihan, E., Courtney, D. F., Quill, D. S., Buckley, D., O’Riordan, D. S., O’Donncll, J. A., Gray, W. P., O’Donnell, J. A., Hill, A. D. K., O’Dwycr, P. J., MacErlean, D. P., Kerin, M. J., Couse, N. F., MacFie, J., Campbell, D., McBride, K., Geraghty, J. G., MacErlean, D., Murphy, J. J., Kirwan, W. O., Kaar, K., Docrat, H., Malik, S., Egan, J., Davidson, I. R., Hurley, J., Keeling, P., Rowley, H., Kaar, K., O’Sullivan, S. T., and Brady, M. P.

Published
1991
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31. Stationary Crystal Diffraction with a Monochromatic Convergent X-Ray Source and Application for Macromolecular Crystal Data Collection

Author

Ho, J. X, Snell, E. H, Sisk, R. C, Ruble, J. R, Carter, D. C, Owens, S. M, and Gibson, W. M

Subjects
Solid-State Physics
Abstract

A diffraction geometry utilizing convergent X-rays from a polycapillary optic incident on a stationary crystal is described. A mathematical simulation of the resulting diffraction pattern (in terms of spot shape, position and intensity) is presented along with preliminary experimental results recorded from a lysozyme crystal. The effective source coverage factor is introduced to bring the reflection intensities onto the same scale. The feasibility of its application to macromolecular crystal data collection is discussed.

Published
1997

42. Preliminary crystallographic studies of four crystal forms of serum albumin

Author

Carter, D. C, Chang, B, Ho, J. X, Keeling, K, and Krishnasami, Z

Subjects
Life Sciences (General)
Abstract

Several crystal forms of serum albumin suitable for three-dimensional structure determination have been grown. These forms include crystals of recombinant and wild-type human serum albumin, baboon serum albumin, and canine serum albumin. The intrinsic limits of X-ray diffraction for these crystals are in the range 0.28-0.22 nm. Two of the crystal forms produced from human and canine albumin include incorporated long-chain fatty acids. Molecular replacement experiments have been successfully conducted on each crystal form using the previously determined atomic coordinates of human serum albumin illustrating the conserved tertiary structure.

Published
1994
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43. Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV

Author

Lim, K, Ho, J. X, Keeling, K, Gilliland, G. L, Ji, X, Ruker, F, and Carter, D. C

Subjects
Life Sciences (General)
Abstract

The 3-dimensional crystal structure of glutathione S-transferase (GST) of Schistosoma japonicum (Sj) fused with a conserved neutralizing epitope on gp41 (glycoprotein, 41 kDa) of human immunodeficiency virus type 1 (HIV-1) (Muster T et al., 1993, J Virol 67:6642-6647) was determined at 2.5 A resolution. The structure of the 3-3 isozyme rat GST of the mu gene class (Ji X, Zhang P, Armstrong RN, Gilliland GL, 1992, Biochemistry 31:10169-10184) was used as a molecular replacement model. The structure consists of a 4-stranded beta-sheet and 3 alpha-helices in domain 1 and 5 alpha-helices in domain 2. The space group of the Sj GST crystal is P4(3)2(1)2, with unit cell dimensions of a = b = 94.7 A, and c = 58.1 A. The crystal has 1 GST monomer per asymmetric unit, and 2 monomers that form an active dimer are related by crystallographic 2-fold symmetry. In the binding site, the ordered structure of reduced glutathione is observed. The gp41 peptide (Glu-Leu-Asp-Lys-Trp-Ala) fused to the C-terminus of Sj GST forms a loop stabilized by symmetry-related GSTs. The Sj GST structure is compared with previously determined GST structures of mammalian gene classes mu, alpha, and pi. Conserved amino acid residues among the 4 GSTs that are important for hydrophobic and hydrophilic interactions for dimer association and glutathione binding are discussed.

Published
1994

44. Structure of a human monoclonal antibody Fab fragment against gp41 of human immunodeficiency virus type

Author

He, X. M, Ruker, F, Casale, E, and Carter, D. C

Subjects
Life Sciences (General)
Abstract

The three-dimensional structure of a human monoclonal antibody (Fab), which binds specifically to a major epitope of the transmembrane protein gp41 of the human immunodeficiency virus type 1, has been determined by crystallographic methods to a resolution of 2.7 A. It has been previously determined that this antibody recognizes the epitope SGKLICTTAVPWNAS, belongs to the subclass IgG1 (kappa), and exhibits antibody-dependent cellular cytotoxicity. The quaternary structure of the Fab is in an extended conformation with an elbow bend angle between the constant and variable domains of 175 degrees. Structurally, four of the hypervariable loops can be classified according to previously recognized canonical structures. The third hypervariable loops of the heavy (H3) and light chain (L3) are structurally distinct. Hypervariable loop H3, residues 102H-109H, is unusually extended from the surface. The complementarity-determining region forms a hydrophobic binding pocket that is created primarily from hypervariable loops L3, H3, and H2.

Published
1992

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