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183 results on '"Caruntu, Ana"'

1. Complex Interaction Among Immune, Inflammatory, and Carcinogenic Mechanisms in the Head and Neck Squamous Cell Carcinoma

Author

Caruntu, Ana, Scheau, Cristian, Tampa, Mircea, Georgescu, Simona Roxana, Caruntu, Constantin, Tanase, Cristiana, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Pokorski, Mieczyslaw, editor

Published
2021
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2. Capsaicin: Emerging Pharmacological and Therapeutic Insights.

Author

Petran, Elena Madalina, Periferakis, Argyrios, Troumpata, Lamprini, Periferakis, Aristodemos-Theodoros, Scheau, Andreea-Elena, Badarau, Ioana Anca, Periferakis, Konstantinos, Caruntu, Ana, Savulescu-Fiedler, Ilinca, Sima, Romina-Marina, Calina, Daniela, Constantin, Carolina, Neagu, Monica, Caruntu, Constantin, and Scheau, Cristian

Published
2024
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3. The Interplay between Obesity and Inflammation.

Author

Savulescu-Fiedler, Ilinca, Mihalcea, Razvan, Dragosloveanu, Serban, Scheau, Cristian, Baz, Radu Octavian, Caruntu, Ana, Scheau, Andreea-Elena, Caruntu, Constantin, and Benea, Serban Nicolae

Subjects
CELL anatomy, QUALITY of life, CELLULAR signal transduction, FAT cells, PHENOTYPIC plasticity, WEIGHT loss
Abstract

Obesity is an important condition affecting the quality of life of numerous patients and increasing their associated risk for multiple diseases, including tumors and immune-mediated disorders. Inflammation appears to play a major role in the development of obesity and represents a central point for the activity of cellular and humoral components in the adipose tissue. Macrophages play a key role as the main cellular component of the adipose tissue regulating the chronic inflammation and modulating the secretion and differentiation of various pro- and anti-inflammatory cytokines. Inflammation also involves a series of signaling pathways that might represent the focus for new therapies and interventions. Weight loss is essential in decreasing cardiometabolic risks and the degree of associated inflammation; however, the latter can persist for long after the excess weight is lost, and can involve changes in macrophage phenotypes that can ensure the metabolic adjustment. A clear understanding of the pathophysiological processes in the adipose tissue and the interplay between obesity and chronic inflammation can lead to a better understanding of the development of comorbidities and may ensure future targets for the treatment of obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Author

Periferakis, Argyrios, primary, Periferakis, Aristodemos-Theodoros, additional, Troumpata, Lamprini, additional, Dragosloveanu, Serban, additional, Timofticiuc, Iosif-Aliodor, additional, Georgatos-Garcia, Spyrangelos, additional, Scheau, Andreea-Elena, additional, Periferakis, Konstantinos, additional, Caruntu, Ana, additional, Badarau, Ioana Anca, additional, Scheau, Cristian, additional, and Caruntu, Constantin, additional

Published
2024
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5. Role of Cannabinoids in Oral Cancer

Author

Cretu, Brigitte, primary, Zamfir, Alexandra, additional, Bucurica, Sandica, additional, Scheau, Andreea Elena, additional, Savulescu Fiedler, Ilinca, additional, Caruntu, Constantin, additional, Caruntu, Ana, additional, and Scheau, Cristian, additional

Published
2024
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6. Tumour Microenvironment in Skin Carcinogenesis

Author

Georgescu, Simona Roxana, Tampa, Mircea, Mitran, Cristina Iulia, Mitran, Madalina Irina, Caruntu, Constantin, Caruntu, Ana, Lupu, Mihai, Matei, Clara, Constantin, Carolina, Neagu, Monica, Crusio, Wim E., Series Editor, Lambris, John D., Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, and Birbrair, Alexander, editor

Published
2020
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8. Kaempferol: A Review of Current Evidence of Its Antiviral Potential

Author

Periferakis, Argyrios, primary, Periferakis, Aristodemos-Theodoros, additional, Troumpata, Lamprini, additional, Periferakis, Konstantinos, additional, Scheau, Andreea-Elena, additional, Savulescu-Fiedler, Ilinca, additional, Caruntu, Ana, additional, Badarau, Ioana Anca, additional, Caruntu, Constantin, additional, and Scheau, Cristian, additional

Published
2023
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9. Biomaterials Adapted to Vat Photopolymerization in 3D Printing: Characteristics and Medical Applications.

Author

Timofticiuc, Iosif-Aliodor, Călinescu, Octavian, Iftime, Adrian, Dragosloveanu, Serban, Caruntu, Ana, Scheau, Andreea-Elena, Badarau, Ioana Anca, Didilescu, Andreea Cristiana, Caruntu, Constantin, and Scheau, Cristian

Subjects
PHOTOPOLYMERIZATION, BIOMEDICAL materials, BIOMATERIALS, THREE-dimensional printing, PROBLEM solving
Abstract

Along with the rapid and extensive advancements in the 3D printing field, a diverse range of uses for 3D printing have appeared in the spectrum of medical applications. Vat photopolymerization (VPP) stands out as one of the most extensively researched methods of 3D printing, with its main advantages being a high printing speed and the ability to produce high-resolution structures. A major challenge in using VPP 3D-printed materials in medicine is the general incompatibility of standard VPP resin mixtures with the requirements of biocompatibility and biofunctionality. Instead of developing completely new materials, an alternate approach to solving this problem involves adapting existing biomaterials. These materials are incompatible with VPP 3D printing in their pure form but can be adapted to the VPP chemistry and general process through the use of innovative mixtures and the addition of specific pre- and post-printing steps. This review's primary objective is to highlight biofunctional and biocompatible materials that have been adapted to VPP. We present and compare the suitability of these adapted materials to different medical applications and propose other biomaterials that could be further adapted to the VPP 3D printing process in order to fulfill patient-specific medical requirements. [ABSTRACT FROM AUTHOR]

Published
2024
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19. PLGA Nanoparticles Uptake in Stem Cells from Human Exfoliated Deciduous Teeth and Oral Keratinocyte Stem Cells

Author

Tizu, Maria, primary, Mărunțelu, Ion, additional, Cristea, Bogdan Mihai, additional, Nistor, Claudiu, additional, Ishkitiev, Nikolay, additional, Mihaylova, Zornitsa, additional, Tsikandelova, Rozaliya, additional, Miteva, Marina, additional, Caruntu, Ana, additional, Sabliov, Cristina, additional, Calenic, Bogdan, additional, and Constantinescu, Ileana, additional

Published
2022
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20. The Spectrum of Extraglandular Manifestations in Primary Sjögren's Syndrome.

Author

Mihai, Ancuta, Caruntu, Constantin, Jurcut, Ciprian, Blajut, Florin Cristian, Casian, Mihnea, Opris-Belinski, Daniela, Ionescu, Ruxandra, and Caruntu, Ana

Subjects
SJOGREN'S syndrome, PROGNOSIS, DISEASE complications, MEDICAL research
Abstract

Extraglandular manifestations (EGMs) in primary Sjogren's syndrome (pSS) represent the clinical expression of the systemic involvement in this disease. EGMs are characterized by a wide heterogeneity; virtually any organ or system can be affected, with various degrees of dysfunction. The existing gaps of knowledge in this complex domain of extraglandular extension in pSS need to be overcome in order to increase the diagnostic accuracy of EGMs in pSS. The timely identification of EGMs, as early as from subclinical stages, can be facilitated using highly specific biomarkers, thus preventing decompensated disease and severe complications. To date, there is no general consensus on the diagnostic criteria for the wide range of extraglandular involvement in pSS, which associates important underdiagnosing of EGMs, subsequent undertreatment and progression to severe organ dysfunction in these patients. This review article presents the most recent basic and clinical science research conducted to investigate pathogenic mechanisms leading to EGMs in pSS patients. In addition, it presents the current diagnostic and treatment recommendations and the trends for future therapeutic strategies based on personalized treatment, as well as the latest research in the field of diagnostic and prognostic biomarkers for extraglandular involvement in pSS. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Current Perspectives on the Role of Matrix Metalloproteinases in the Pathogenesis of Basal Cell Carcinoma

Author

Tampa, Mircea, primary, Georgescu, Simona Roxana, additional, Mitran, Madalina Irina, additional, Mitran, Cristina Iulia, additional, Matei, Clara, additional, Caruntu, Ana, additional, Scheau, Cristian, additional, Nicolae, Ilinca, additional, Matei, Andreea, additional, Caruntu, Constantin, additional, Constantin, Carolina, additional, and Neagu, Monica, additional

Published
2021
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33. Applications of Nanosized-Lipid-Based Drug Delivery Systems in Wound Care

Author

Matei, Andreea-Mariana, primary, Caruntu, Constantin, additional, Tampa, Mircea, additional, Georgescu, Simona Roxana, additional, Matei, Clara, additional, Constantin, Maria Magdalena, additional, Constantin, Traian Vasile, additional, Calina, Daniela, additional, Ciubotaru, Diana Alina, additional, Badarau, Ioana Anca, additional, Scheau, Cristian, additional, and Caruntu, Ana, additional

Published
2021
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34. Neuroendocrine Factors in Melanoma Pathogenesis

Author

Scheau, Cristian, primary, Draghici, Carmen, additional, Ilie, Mihaela Adriana, additional, Lupu, Mihai, additional, Solomon, Iulia, additional, Tampa, Mircea, additional, Georgescu, Simona Roxana, additional, Caruntu, Ana, additional, Constantin, Carolina, additional, Neagu, Monica, additional, and Caruntu, Constantin, additional

Published
2021
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38. Ramus to Ramus Mandibular Defect Reconstruction with Osteocutaneous Fibula Free Flap – Case Presentation

Author

MURARU, Iulia, MURARU, Dragos, MARINESCU, Bogdan M., TUHAR, Ioana, GUZGANU, Ionut, IONESCU, Paul, MORARU, Liliana, DUMITRU, Catalin, CARUNTU, Ana, LASCAR, Ioan, and GABARA, Adrian

Subjects
Case Reports
Abstract

Introduction: Head and neck defects after tumor resection can be difficult to reconstruct using autogenous tissue without utilizing a free flap. Osteocutaneous fibula free flap is now considered the gold standard used for mandibular reconstruction after resections due to malignancy. Case presentation: We present the case of a 49-year old female known with an ectopic mucoepidermoid carcinoma involving the mandibula from one ramus to another. After tumor resection, we have reconstructed the mandible by using the only method available for reconstruction in this case – an osteocutaneous fibula free flap. We were able to reconstruct the mandible using 3D printed custom-made surgical guides. Discussion: Postoperative imaging showed that the height and symmetry of the mandible were satisfactory. There were no microvascular failures and the intraoral healing time was about 10 days. The donor site skin defect from the left leg was grafted with an autograft harvested from the ipsilateral thigh. The donor site healed uneventfully. Conclusion: Osteocutaneous fibula free flap is a highly effective method and sometimes the only one available for reconstruction of mandibular defects after resection of intraoral malignancies. Modern technologies, such as surgical planning using computer-aided design, play a critical part in extensive reconstructions, lowering the total intervention time.

Published
2020

39. The Effects of Capsaicin on Gastrointestinal Cancers

Author

Popescu, George Denis Alexandru, primary, Scheau, Cristian, additional, Badarau, Ioana Anca, additional, Dumitrache, Mihai-Daniel, additional, Caruntu, Ana, additional, Scheau, Andreea-Elena, additional, Costache, Daniel Octavian, additional, Costache, Raluca Simona, additional, Constantin, Carolina, additional, Neagu, Monica, additional, and Caruntu, Constantin, additional

Published
2020
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42. Cannabinoids in the Pathophysiology of Skin Inflammation

Author

Scheau, Cristian, primary, Badarau, Ioana Anca, additional, Mihai, Livia-Gratiela, additional, Scheau, Andreea-Elena, additional, Costache, Daniel Octavian, additional, Constantin, Carolina, additional, Calina, Daniela, additional, Caruntu, Constantin, additional, Costache, Raluca Simona, additional, and Caruntu, Ana, additional

Published
2020
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43. Neuroendocrine Factors and Head and Neck Squamous Cell Carcinoma: An Affair to Remember

Author

Solomon, Iulia, Voiculescu, Vlad Mihai, Caruntu, Constantin, Lupu, Mihai, Popa, Alexandra, Ilie, Mihaela Adriana, Albulescu, Radu, Caruntu, Ana, Tanase, Cristiana, Constantin, Carolina, Neagu, Monica, and Boda, Daniel

Subjects
Article Subject
Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies. Therefore, the major goal of cancer treatment is inhibition of tumor cell growth and of metastasis development. In order to choose the best management option for HNSCC patients, we need to identify reliable prognostic factors and to develop new molecular techniques in order to obtain a better understanding of therapy resistance. By acting as neurohormones, neurotransmitters, or neuromodulators, the neuroendocrine factors are able to signal the maintenance of physiological homeostasis or progression to malignant disease. Certain neuropeptides possess strong antitumor properties acting as tumor suppressors and immunomodulators, providing additional benefits for future potential therapeutic strategies. In light of the current understanding, cancer starts as a localized disease that can be effectively treated if discovered on proper time. Unfortunately, more than often cancer cells migrate to the surrounding tissues generating distant metastases, thus making the prognosis and survival in this stage much worse. As cellular migration is mandatory for tumor invasion and metastasis development, searching for alternate controllers of these processes, such as the neuroendocrine factors, it is an active tremendous task.

Published
2018
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44. Mediators of Inflammation – A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Author

Tampa, Mircea, Mitran, Madalina Irina, Mitran, Cristina Iulia, Sarbu, Maria Isabela, Matei, Clara, Nicolae, Ilinca, Caruntu, Ana, Tocut, Sandra Milena, Popa, Mircea Ioan, Caruntu, Constantin, and Georgescu, Simona Roxana

Subjects
stomatognathic diseases, Article Subject
Abstract

Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflammation, strong evidence supporting the association between chronic inflammation and carcinogenesis. Moreover, an increasing number of studies have investigated the role of different mediators of inflammation in the early detection of OSCC. In this review, we have summarized the main markers of inflammation that could be useful in diagnosis and shed some light in OSCC pathogenesis.

Published
2018
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46. From Normal Skin to Squamous Cell Carcinoma: A Quest for Novel Biomarkers

Author

Voiculescu, Vlad, Calenic, Bogdan, Ghita, Mihaela, Lupu, Mihai, Caruntu, Ana, Moraru, Liliana, Voiculescu, Suzana, Ion, Alexandra, Greabu, Maria, Ishkitiev, Nikolay, and Caruntu, Constantin

Subjects
Article Subject
Abstract

Squamous cells carcinoma (SCC) is the second most frequent of the keratinocyte-derived malignancies after basal cell carcinoma and is associated with a significant psychosocial and economic burden for both the patient himself and society. Reported risk factors for the malignant transformation of keratinocytes and development of SCC include ultraviolet light exposure, followed by chronic scarring and inflammation, exposure to chemical compounds (arsenic, insecticides, and pesticides), and immune-suppression. Despite various available treatment methods and recent advances in noninvasive or minimal invasive diagnostic techniques, the risk recurrence and metastasis are far from being negligible, even in patients with negative histological margins and lymph nodes. Analyzing normal, dysplastic, and malignant keratinocyte proteome holds special promise for novel biomarker discovery in SCC that could be used in the future for early detection, risk assessment, tumor monitoring, and development of targeted therapeutic strategies.

Published
2016
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47. Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma

Author

Lupu, Mihai, Caruntu, Constantin, Ghita, Mihaela Adriana, Voiculescu, Vlad, Voiculescu, Suzana, Rosca, Adrian E., Caruntu, Ana, Moraru, Liliana, Popa, Iris Maria, Calenic, Bogdan, Greabu, Maria, and Costea, Daniela Elena

Subjects
integumentary system, Article Subject
Abstract

Basal cell carcinoma (BCC) is the world’s leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predisposed individuals, this being reflected by the anatomical distribution of lesions mainly on sun-exposed skin areas. Early diagnosis and prompt management are of crucial importance in order to prevent local tissue destruction and subsequent disfigurement. Although various noninvasive or minimal invasive techniques have demonstrated their utility in increasing diagnostic accuracy of BCC and progress has been made in its treatment options, recurrent, aggressive, and metastatic variants of BCC still pose significant challenge for the healthcare system. Analysis of gene expression and proteomic profiling of tumor cells and of tumoral microenvironment in various tissues strongly suggests that certain molecules involved in skin cancer pathogenic pathways might represent novel predictive and prognostic biomarkers in BCC.

Published
2016
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48. Neuroendocrine factors: The missing link in non-melanoma skin cancer

Author

Lupu, Mihai, primary, Caruntu, Ana, additional, Caruntu, Constantin, additional, Papagheorghe, Laura Maria Lucia, additional, Ilie, Mihaela Adriana, additional, Voiculescu, Vlad, additional, Boda, Daniel, additional, Constantin, Carolina, additional, Tanase, Cristiana, additional, Sifaki, Maria, additional, Drakoulis, Nikolaos, additional, Mamoulakis, Charalampos, additional, Tzanakakis, George, additional, Neagu, Monica, additional, Spandidos, Demetrios A., additional, Izotov, Boris N., additional, and Tsatsakis, Aristides M., additional

Published
2017
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50. Reflectance confocal microscopy and dermoscopy for in vivo, non-invasive skin imaging of superficial basal cell carcinoma

Author

GHITA, MIHAELA A., primary, CARUNTU, CONSTANTIN, additional, ROSCA, ADRIAN E., additional, KALESHI, HARILLAQ, additional, CARUNTU, ANA, additional, MORARU, LILIANA, additional, DOCEA, ANCA OANA, additional, ZURAC, SABINA, additional, BODA, DANIEL, additional, NEAGU, MONICA, additional, SPANDIDOS, DEMETRIOS A., additional, and TSATSAKIS, ARISTIDIS M., additional

Published
2016
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