Search

Your search keyword '"Carvalho, Edgar M."' showing total 1,028 results
Start Over Author "Carvalho, Edgar M."
1,028 results on '"Carvalho, Edgar M."'

1. Disseminated Leishmaniasis, a Severe Form of Leishmania braziliensis Infection

Author

Machado, Paulo R.L., Lago, Alexsandro, Cardoso, Thiago M., Magalhaes, Andrea, Carvalho, Lucas P., Lago, Taina, Carvalho, Augusto M., Costa, Rubia, and Carvalho, Edgar M.

Subjects
Leishmaniasis -- Causes of -- Drug therapy -- Patient outcomes, Health
Abstract

Disseminated leishmaniasis (DL) is an aggressive form of tegumentary leishmaniasis associated with multiple and polymorphic cutaneous lesions (acneiform and inflammatory papules, nodules, and ulcers) in [greater than or equal to] [...]

Published
2024
Full Text
View/download PDF

8. Association of miltefosine with granulocyte and macrophage colony-stimulating factor (GM-CSF) in the treatment of cutaneous leishmaniasis in the Amazon region: A randomized and controlled trial

Author

Mendes, Luciana, Guerra, Jorge Oliveira, Costa, Bleno, Silva, Aríneia Soares da, Guerra, Maria das Graças Barbosa, Ortiz, Jéssica, Doria, Susan Smith, Silva, George Villarouco da, de Jesus, Denison Vital, Barral-Netto, Manoel, Penna, Gerson, Carvalho, Edgar M., and Machado, Paulo R.L.

Published
2021
Full Text
View/download PDF

10. Improved Treatment Outcome Following the Use of a Wound Dressings in Cutaneous Leishmaniasis Lesions.

Author

Borba, Pedro B., Lago, Jamile, Lago, Tainã, Araújo-Pereira, Mariana, Queiroz, Artur T. L., Barud, Hernane S., Carvalho, Lucas P., Machado, Paulo R. L., Carvalho, Edgar M., and de Oliveira, Camila I.

Subjects
LEISHMANIASIS, CUTANEOUS leishmaniasis, TREATMENT effectiveness, SKIN injuries, NEGLECTED diseases, SKIN diseases
Abstract

Leishmaniasis, caused by Leishmania parasites, is a neglected tropical disease and Cutaneous Leishmaniasis (CL) is the most common form. Despite the associated toxicity and adverse effects, Meglumine antimoniate (MA) remains the first-choice treatment for CL in Brazil, pressing the need for the development of better alternatives. Bacterial NanoCellulose (BNC), a biocompatible nanomaterial, has unique properties regarding wound healing. In a previous study, we showed that use of topical BNC + systemic MA significantly increased the cure rate of CL patients, compared to treatment with MA alone. Herein, we performed a study comparing the combination of a wound dressing (BNC or placebo) plus systemic MA versus systemic MA alone, in CL caused by Leishmania braziliensis. We show that patients treated with the combination treatment (BNC or placebo) + MA showed improved cure rates and decreased need for rescue treatment, although differences compared to controls (systemic MA alone) were not significant. However, the overall time-to-cure was significantly lower in groups treated with the combination treatment (BNC+ systemic MA or placebo + systemic MA) in comparison to controls (MA alone), indicating that the use of a wound dressing improves CL treatment outcome. Assessment of the immune response in peripheral blood showed an overall downmodulation in the inflammatory landscape and a significant decrease in the production of IL-1a (p < 0.05) in patients treated with topical BNC + systemic MA. Our results show that the application of wound dressings to CL lesions can improve chemotherapy outcome in CL caused by L. braziliensis. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity

Author

Farias Amorim, Camila, primary, Lovins, Victoria M., additional, Singh, Tej Pratap, additional, Novais, Fernanda O., additional, Harris, Jordan C., additional, Lago, Alexsandro S., additional, Carvalho, Lucas P., additional, Carvalho, Edgar M., additional, Beiting, Daniel P., additional, Scott, Phillip, additional, and Grice, Elizabeth A., additional

Published
2023
Full Text
View/download PDF

17. Forecasting temporal dynamics of cutaneous leishmaniasis in Northeast Brazil.

Author

Lewnard, Joseph A, Jirmanus, Lara, Júnior, Nivison Nery, Machado, Paulo R, Glesby, Marshall J, Ko, Albert I, Carvalho, Edgar M, Schriefer, Albert, and Weinberger, Daniel M

Subjects
Animals, Humans, Psychodidae, Leishmaniasis, Cutaneous, Models, Statistical, Ecology, Public Health, Weather, Population Dynamics, Brazil, Leishmaniasis, Cutaneous, Models, Statistical, Tropical Medicine, Biological Sciences, Medical and Health Sciences
Abstract

IntroductionCutaneous leishmaniasis (CL) is a vector-borne disease of increasing importance in northeastern Brazil. It is known that sandflies, which spread the causative parasites, have weather-dependent population dynamics. Routinely-gathered weather data may be useful for anticipating disease risk and planning interventions.Methodology/principal findingsWe fit time series models using meteorological covariates to predict CL cases in a rural region of Bahía, Brazil from 1994 to 2004. We used the models to forecast CL cases for the period 2005 to 2008. Models accounting for meteorological predictors reduced mean squared error in one, two, and three month-ahead forecasts by up to 16% relative to forecasts from a null model accounting only for temporal autocorrelation.SignificanceThese outcomes suggest CL risk in northeastern Brazil might be partially dependent on weather. Responses to forecasted CL epidemics may include bolstering clinical capacity and disease surveillance in at-risk areas. Ecological mechanisms by which weather influences CL risk merit future research attention as public health intervention targets.

Published
2014

25. Influence of HTLV-1 on the clinical, microbiologic and immunologic presentation of tuberculosis

Author

Bastos, Maria, Santos, Silvane B, Souza, Anselmo, Finkmoore, Brooke, Bispo, Ohana, Barreto, Tasso, Cardoso, Ingrid, Bispo, Iana, Bastos, Flávia, Pereira, Daniele, Riley, Lee, and Carvalho, Edgar M

Abstract

AbstractBackgroundHTLV-1 is associated with increased susceptibility to Mycobacterium tuberculosis infection and severity of tuberculosis. Although previous studies have shown that HTLV-1 infected individuals have a low frequency of positive tuberculin skin test (TST) and decreasing in lymphoproliferative responses compared to HTLV-1 uninfected persons, these studies were not performed in individuals with history of tuberculosis or evidence of M. tuberculosis infection. Therefore the reasons why HTLV-1 infection increases susceptibility to infection and severity of tuberculosis are not understood.The aim of this study was to evaluate how HTLV-1 may influence the clinical, bacteriologic and immunologic presentation of tuberculosis.MethodsThe study prospectively enrolled and followed 13 new cases of tuberculosis associated with HTLV-1 (cases) and 25 patients with tuberculosis without HTLV-1 infection (controls). Clinical findings, bacterial load in the sputum, x-rays, immunological response and death were compared in the two groups.ResultsThere were no differences in the demographic, clinical and TST response between the two study groups. IFN-γ and TNF-α production was higher in unstimulated cultures of mononuclear cells of case than in control patients (p

Published
2012

30. Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies

Author

Pilling, Olivia A., primary, Reis-Cunha, João L., additional, Grace, Cooper A., additional, Berry, Alexander S. F., additional, Mitchell, Matthew W., additional, Yu, Jane A., additional, Malekshahi, Clara R., additional, Krespan, Elise, additional, Go, Christina K., additional, Lombana, Cláudia, additional, Song, Yun S., additional, Amorim, Camila F., additional, Lago, Alexsandro S., additional, Carvalho, Lucas P., additional, Carvalho, Edgar M., additional, Brisson, Dustin, additional, Scott, Phillip, additional, Jeffares, Daniel C., additional, and Beiting, Daniel P., additional

Published
2023
Full Text
View/download PDF

35. The skin microbiome enhances disease through IL-1b and delays healing in cutaneous leishmaniasis patients

Author

Farias Amorim, Camila, primary, Lovins, Victoria M., additional, Singh, Tej Pratap, additional, Novais, Fernanda O., additional, Harris, Jordan C., additional, Lago, Alexsandro S., additional, Carvalho, Lucas P., additional, Carvalho, Edgar M., additional, Beiting, Daniel P., additional, Scott, Phillip, additional, and Grice, Elizabeth A., additional

Published
2023
Full Text
View/download PDF

38. Dogs Harbor Leishmania braziliensis and Participate in the Transmission Cycle of Human Tegumentary Leishmaniasis.

Author

Lago, Jamile, Fraga, Deborah, Coelho, Lívia, Jesus, Matheus Silva de, Leite, Bruna, Werneck, Guilherme L., Arruda, Sérgio, Lago, Ednaldo, Carvalho, Edgar M., and Bacellar, Olivia

Subjects
SAND flies, LEISHMANIASIS, DOGS, LEISHMANIA, SKIN ulcers, LEISHMANIA infantum, FLEA control
Abstract

Dogs play an important role in transmission of Leishmania infantum, but epidemiologic and clinical studies of canine tegumentary leishmaniasis (CTL) are scarce. In an endemic area of human American tegumentary leishmaniasis (ATL) caused by Leishmania braziliensis, we determine the prevalence and incidence of both CTL and subclinical (SC) L. braziliensis infection in dogs and evaluated if the presence of dogs with CTL or SC L. braziliensis infection is associated with the occurrence of human ATL. SC infection in healthy animals and CTL in animals with ulcers were determined by PCR on biopsied healthy skin or on ulcers or by detecting antibodies against soluble leishmania antigen. We compared the occurrence of human ATL in homes with dogs with CTL or SC infection with control homes without dogs or with dogs without CTL or SC infection. The prevalence of SC infection was 35% and of CTL 31%. The incidence of SC infection in dogs was 4.6% and of CTL 9.3%. The frequency of ATL in humans was 50% in homes with infected dogs and 13% in homes without L. braziliensis infection in dogs. CTL and SC infection is highly prevalent, and dogs may participate in the transmission chain of L. braziliensis. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

39. Blood cytokines in atopic and non‐atopic eosinophilic moderate to severe asthmatics

Author

Fernandes, Jamille Souza, primary, Cardoso, Luciana Santos, additional, Carneiro, Norma Vilany Queiroz, additional, das Chagas, Gabriela Pimentel Pinheiro, additional, Santana, Cinthia Vila Nova, additional, Atta, Ajax M., additional, de Oliveira, Isabela Silva, additional, Carvalho, Edgar M., additional, Figueiredo, Camila Alexandrina, additional, and Cruz, Álvaro A., additional

Published
2022
Full Text
View/download PDF

41. Serodiagnosis and therapeutic monitoring of New-World tegumentary leishmaniasis using synthetic type-2 glycoinositolphospholipid-based neoglycoproteins

Author

Viana, Sayonara M., primary, Montoya, Alba L., additional, Carvalho, Augusto M., additional, de Mendonça, Brunele S., additional, Portillo, Susana, additional, Olivas, Janet J., additional, Karimi, Nasim H., additional, Estevao, Igor L., additional, Ortega-Rodriguez, Uriel, additional, Carvalho, Edgar M., additional, Dutra, Walderez O., additional, Maldonaldo, Rosa A., additional, Michael, Katja, additional, de Oliveira, Camila I., additional, and Almeida, Igor C., additional

Published
2022
Full Text
View/download PDF

42. Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies

Author

Pilling, Olivia A., primary, Reis-Cunha, Joao L, additional, Grace, Cooper A, additional, Berry, Alexander SF, additional, Mitchell, Matthew W, additional, Yu, Jane A, additional, Malekshahi, Clara, additional, Krespan, Elise, additional, Go, Christina K, additional, Lombana, Claudia, additional, Song, Yun S, additional, Amorim, Camila F, additional, Lago, Alexsandro S, additional, Carvalho, Lucas P, additional, Carvalho, Edgar M, additional, Brisson, Dustin, additional, Scott, Phillip, additional, Jeffares, Daniel C, additional, and Beiting, Daniel P., additional

Published
2022
Full Text
View/download PDF

47. Sistema de Informação Contabilístico e Fiscal: Análise Comparativa entre Portugal e a Guiné-Bissau

Author

Carvalho, Edgar M

Subjects
Guiné-Bissau, Sistema Contabilístico, Portugal, Sistema Fiscal
Abstract

As normas contabilísticas registam uma grande evolução de acordo com as exigências económicas que se vivem em todo mundo. Nesta modernização, não é menos importante referir, que o processo de normalização contabilística desenvolvido pelo International Accounting Standards Board (IASB), através das Normas Internacionais de Contabilidade (NIC) demonstram eficiência, responsabilidade e transparência nos mercados. Assim, o presente projeto aplicado tem, como objetivo, estudar as normas contabilísticas e fiscais na Guiné-Bissau e apresentar uma análise comparativa entre os Sistemas Contabilísticos existentes em Portugal e na Guiné-Bissau. A metodologia de investigação divide-se numa análise teórica centrada na contabilidade e na fiscalidade na Guiné-Bissau, nomeadamente, na Organisation pour l´Harmonisation en Afrique du Droit des Affaires (OHADA) e, assim como, nos processos da convergência para as NIC. A análise empírica desenvolveu-se através do método de caso de estudo (Yin, 2018) e centrou-se numa análise de uma empresa especializada na comercialização da castanha de caju, tendo sido evidenciadas as riquezas naturais do país (Flora e Fauna) decorrente da atividade comercial da empresa. Paralelamente, foram estudadas as suas demonstrações financeiras dos exercícios económicos de 2017 a 2020, tendo-se apresentado uma análise comparativa entre os Sistemas Contabilísticos existentes em Portugal e na Guiné-Bissau. Este documento do projeto aplicado sistematiza todas as análises referidas e, ainda, foram escritas as conclusões e as limitações.

Published
2022

48. Pioglitazone, a Peroxisome Proliferator-Activated Receptor-γ Agonist, Downregulates the Inflammatory Response in Cutaneous Leishmaniasis Patients Without Interfering in Leishmania braziliensis Killing by Monocytes

Author

Nascimento, Maurício T., Cordeiro, Ravena S. O., Abreu, Cayo, Santos, Camila P., Peixoto, Fábio, Duarte, Gabriela A., Cardoso, Thiago, de Oliveira, Camila I., Carvalho, Edgar M., and Carvalho, Lucas P.

Subjects
Microbiology (medical), Infectious Diseases, Immunology, Microbiology
Abstract

Patients with cutaneous leishmaniasis (CL) due toLeishmania braziliensisinfection have an exacerbated inflammatory response associated with tissue damage and ulcer development. An increase in the rate of patients who fail therapy with pentavalent antimony has been documented. An adjuvant therapy with an anti-inflammatory drug with the potential ofLeishmaniakilling would benefit CL patients. The aim of the present study was to investigate the contribution of peroxisome proliferator-activated receptor-γ (PPAR-γ) activation by pioglitazone in the regulation of the inflammatory response andL. braziliensiskilling by monocytes. Pioglitazone is an oral drug used in the treatment of diabetes, and its main mechanism of action is through the activation of PPAR-γ, which is expressed in many cell types of the immune response. We found that activation of PPAR-γ by pioglitazone decreases the inflammatory response in CL patients without affectingL. braziliensiskilling by monocytes. Our data suggest that pioglitazone may serve as an adjunctive treatment for CL caused byL. braziliensis.

Published
2022

49. Leishmania braziliensis causing human disease in Northeast Brazil presents loci with genotypes in long-term equilibrium

Author

Silva, Juliana A., primary, Pinheiro, Ana Isabelle, additional, Dourado, Maria Luiza, additional, Medina, Lilian, additional, Queiroz, Adriano, additional, Guimarães, Luiz Henrique, additional, Lessa, Marcus Miranda, additional, Lago, Ednaldo L., additional, Machado, Paulo Roberto L., additional, Wilson, Mary E., additional, Carvalho, Edgar M., additional, and Schriefer, Albert, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results