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2. Scanned compound document encoding using multiscale recurrent patterns

Author

Francisco, N.C., Rodrigues, N.M.M., da Silva, E.A.B., de Carvalho, M.B., de Faria, S.M.M., and Silva, V.M.M.

Subjects
Image coding -- Innovations, Mathematical optimization -- Usage, Pixels -- Measurement, Business, Computers, Electronics, Electronics and electrical industries
Published
2010

5. Foreword

Author

de Carvalho, M.B., Davison, A.C., and Beirlant, J.

Published
2012

6. Learning Analytics for a Puzzle Game to Discover the Puzzle-Solving Tactics of Players

Author

Vahdat, M., Carvalho, M.B., Funk, M., Rauterberg, G.W.M., Hu, J., Anguita, D., Verbert, K., Sharples, M., Klobučar, T., and Creative Computing

Subjects
Elementary cognitive task, Serious games, Process (engineering), Computer science, media_common.quotation_subject, Learning analytics, Process mining, Context (language use), Puzzle games, 02 engineering and technology, computer.software_genre, Educational data mining, Cluster analysis, Human–computer interaction, 0202 electrical engineering, electronic engineering, information engineering, Quality (business), Technology Enhanced Learning, media_common, Multimedia, 05 social sciences, ComputingMilieux_PERSONALCOMPUTING, 050301 education, Variety (cybernetics), 020201 artificial intelligence & image processing, 0503 education, computer
Abstract

Games can be used as effective learning tools, proved to enhance players’ performance in a wide variety of cognitive tasks. In this context, Learning Analytics (LA) can be used to improve game quality and to support the achievement of learning goals. In this paper, we investigate the use of LA in digital puzzle games, which are commonly used for educational purposes. We describe our approach to explore the way players learn game skills and solve problems in an open-source puzzle game called Lix. We performed an initial study with 15 participants, in which we applied Process Mining and cluster analysis in a three-step analysis approach. This approach can be used as a basis for recommending interventions so as to facilitate the puzzle-solving process of players.

Published
2016

7. Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer

Author

Lesseur, C. Diergaarde, B. Olshan, A.F. Wünsch-Filho, V. Ness, A.R. Liu, G. Lacko, M. Eluf-Neto, J. Franceschi, S. Lagiou, P. Macfarlane, G.J. Richiardi, L. Boccia, S. Polesel, J. Kjaerheim, K. Zaridze, D. Johansson, M. Menezes, A.M. Curado, M.P. Robinson, M. Ahrens, W. Canova, C. Znaor, A. Castellsagué, X. Conway, D.I. Holcátová, I. Mates, D. Vilensky, M. Healy, C.M. Szeszenia-Dabrowska, N. Fabiánová, E. Lissowska, J. Grandis, J.R. Weissler, M.C. Tajara, E.H. Nunes, F.D. De Carvalho, M.B. Thomas, S. Hung, R.J. Peters, W.H.M. Herrero, R. Cadoni, G. Bueno-De-Mesquita, H.B. Steffen, A. Agudo, A. Shangina, O. Xiao, X. Gaborieau, V. Chabrier, A. Anantharaman, D. Boffetta, P. Amos, C.I. McKay, J.D. Brennan, P.

Abstract

We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10 â'8), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci - 9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1∗1301-HLA-DQA1∗0103-HLA-DQB1∗0603 (odds ratio (OR) = 0.59, P = 2.7 × 10-9). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10-6) than in HPV-negative (OR = 0.75, P = 0.16) cancers. © 2016 Nature America, Inc. part of Springer Nature, All Rights reserved.

Published
2016

11. Tutorial : service-oriented architecture (SOA) development for serious games

Author

Carvalho, M.B., Hu, J., Bellotti, F., de Gloria, A., Rauterberg, G.W.M., Chorianopoulos, K., Divitini, M., Hauge, J., Jaccheri, L., and Malaka, R.

Subjects
Video game development, Multimedia, Software_GENERAL, Computer science, computer.internet_protocol, Computer Science (all), ComputingMilieux_PERSONALCOMPUTING, Theoretical Computer Science, Service-oriented architecture, computer.software_genre, Development (topology), Session (computer science), Architecture, Game Developer, computer
Abstract

This tutorial aims to introduce the benefits of applying a service-oriented architecture (SOA) approach to serious games developers. For that end, we propose a hands-on session in which we will provide information on state-of-the-art services for serious games and guide developers in rethinking one of their existing games or game ideas using our SOA framework for serious games.

Published
2015

12. Mapping learning and game mechanics for serious games analysis

Author

Arnab, S., Lim, T., Carvalho, M.B., Bellotti, F., de Freitas, S., Louchart, S., Suttie, N., Berta, R., De Gloria, A., Arnab, S., Lim, T., Carvalho, M.B., Bellotti, F., de Freitas, S., Louchart, S., Suttie, N., Berta, R., and De Gloria, A.

Abstract

Although there is a consensus on the instructional potential of Serious Games (SGs), there is still a lack of methodologies and tools not only for design but also to support analysis and assessment. Filling this gap is one of the main aims of the Games and Learning Alliance (http://www.galanoe.eu) European Network of Excellence on Serious Games, which has a focus upon pedagogy-driven SGs. This paper relies on the assumption that the fundamental aspect of SG design consists in the translation of learning goals/practices into mechanical element of gameplay, serving to an instructional purpose beside that of play and fun. This paper proposes the Learning Mechanics–Game Mechanics (LM-GM) model, which supports SG analysis and design by allowing reflection on the various pedagogical and game elements in an SG. The LM-GM model includes a set of pre-defined game mechanics and pedagogical elements that we have abstracted from literature on game studies and learning theories. Designers and analysts can exploit these mechanics to draw the LM-GM map for a game, so as to identify and highlight its main pedagogical and entertainment features, and their interrelations. The tool may also be useful for teachers to evaluate the effectiveness of a given game and better understand how to implement it in educational settings. A case study is reported to illustrate the framework's support in determining how gameplay and pedagogy intertwine in an SG. Finally, the paper presents the results of two comparative user tests demonstrating the advantages of the proposed model with respect to a similar state-of-the-art framework.

Published
2015

15. Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer

Author

Rodrigues, P.R.S., primary, Maia, L.L., additional, Santos, M., additional, Peterle, G.T., additional, Alves, L.U., additional, Takamori, J.T., additional, Souza, R.P., additional, Barbosa, W.M., additional, Mercante, A.M.C., additional, Nunes, F.D., additional, Carvalho, M.B., additional, Tajara, E.H., additional, Louro, I.D., additional, and Silva-Conforti, A.M.A., additional

Published
2015
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16. Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism

Author

Stur, E., primary, Agostini, L.P., additional, Garcia, F.M., additional, Peterle, G.T., additional, Maia, L.L., additional, Mendes, S.O., additional, Anders, Q.S., additional, Reis, R.S., additional, Santos, J.A., additional, Ventorim, D.P., additional, Carvalho, M.B., additional, Tajara, E.H., additional, Santos, M., additional, Paula, F., additional, Silva-Conforti, A.M.A., additional, and Louro, I.D., additional

Published
2015
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17. FAS ligand expression in inflammatory infiltrate lymphoid cells as a prognostic marker in oral squamous cell carcinoma

Author

Peterle, G.T., primary, Santos, M., additional, Mendes, S.O., additional, Carvalho-Neto, P.B., additional, Maia, L.L., additional, Stur, E., additional, Agostini, L.P., additional, Silva, C.V.M., additional, Trivilin, L.O., additional, Nunes, F.D., additional, Carvalho, M.B., additional, Tajara, E.H., additional, Louro, I.D., additional, and Silva-Conforti, A.M.A., additional

Published
2015
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19. Keratins 17 and 19 expression as prognostic markers in oral squamous cell carcinoma

Author

Coelho, B.A., primary, Peterle, G.T., additional, Santos, M., additional, Agostini, L.P., additional, Maia, L.L., additional, Stur, E., additional, Silva, C.V.M., additional, Mendes, S.O., additional, Almança, C.C.J., additional, Freitas, F.V., additional, Borçoi, A.R., additional, Archanjo, A.B., additional, Mercante, A.M.C., additional, Nunes, F.D., additional, Carvalho, M.B., additional, Tajara, E.H., additional, Louro, I.D., additional, and Silva-Conforti, A.M.A, additional

Published
2015
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20. MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell carcinoma

Author

Anders, Q.S., primary, Stur, E., additional, Agostini, L.P., additional, Garcia, F.M., additional, Reis, R.S., additional, Santos, J.A., additional, Mendes, S.O., additional, Maia, L.L., additional, Peterle, G.T., additional, Stange, V., additional, Carvalho, M.B., additional, Tajara, E.H., additional, Santos, M., additional, Silva-Conforti, A.M.A., additional, and Louro, I.D., additional

Published
2015
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23. Ocorrência de poliúria-polidpsia em eqüinos estabulados - descrição de dois casos de polidipsia psicogênica

Author

Lacerda Neto, J.C., Carvalho, M.B., Martins Filho, L.P., Marques, L.C., Fagliari, J.J., Trinque, C.L.N., and Lima, M.M.

Subjects
psychogenic polydipsia, Eqüino, poliúria- polidipsia, poliuria-polydipsia, Horse, polidipsia psicogênica
Abstract

Dois eqüinos da raça Brasileira de Hipismo, machos, quatro anos de idade, apresentando sinais de poliúria-polidipsia, foram submetidos a completa avaliação clínica e a exames de sangue e urina. Não foram observadas alterações clínicas, hematológicas ou bioquímicas, a não ser um decréscimo na gravidade específica da urina de ambos os animais (1,009 e 1,008). Realizou-se um teste de privação de água de 24 horas e durante esse período a gravidade especifica da urina subiu gradualmente até atingir a normalidade (1,028 e 1,026, respectivamente). O comportamento anormal ocorreu por confinamento excessivo. Os resultados clínicos e de laboratório e o teste de privação de água indicam o diagnóstico de polidipsia psicogênica. Two four-year-old male Brasileiro de Hipismo breed horses presenting signs of polyuria-polydipsia, were submitted to a complete clinical evaluation as well as having blood and urine samples collected for laboratory analysis. No clinical, hematological or biochemical abnormalities were observed, but a significant decrease in urine specific gravity was detected in both horses. One of the horses presented 1,009 and the other 1,008. A 24-hour water deprivation test was carried out and, during this period, the urine specific gravity gradually increased reaching the normal values of 1,028 and 1,026. The abnormal behavior occured as a consequence of an excessive confinement. The clinical and laboratory results associated to the 24-hour water deprivation test indicated a diagnosis of psychogenic polydipsia.

Published
2000

25. Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer

Author

López, R.V.M., primary, Zago, M.A., additional, Eluf-Neto, J., additional, Curado, M.P., additional, Daudt, A.W., additional, da Silva-Junior, W.A., additional, Zanette, D.L., additional, Levi, J.E., additional, de Carvalho, M.B., additional, Kowalski, L.P., additional, Abrahão, M., additional, de Góis-Filho, J.F., additional, Boffetta, P., additional, and Wünsch-Filho, V., additional

Published
2011
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50. Características clínico-epidemológicas do carcinoma epidermóide de cavidade oral no sexo feminino

Author

CARVALHO, M.B. DE, primary, LENZI, J., additional, LEHN, C.N., additional, FAVA, A.S., additional, AMAR, A., additional, KANDA, J.L., additional, WALDER, F., additional, MENEZES, M.B., additional, FRANZI, S.A., additional, MAGALHÃES, M.R. DE, additional, CURIONI, O.A., additional, MARCEL, R., additional, SZELIGA, S., additional, A. SOBRINHO, J. DE, additional, and RAPOPORT, A., additional

Published
2001
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