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4. Factors That Determine Risk for Surgery in Pediatric Patients With Crohn's Disease

Author

Schaefer, Marc E., Machan, Jason T., Kawatu, David, Langton, Christine R., Markowitz, James, Crandall, Wallace, Mack, David R., Evans, Jonathan S., Pfefferkorn, Marian D., Griffiths, Anne M., Otley, Anthony R., Bousvaros, Athos, Kugathasan, Subra, Rosh, Joel R., Keljo, David J., Carvalho, Ryan S., Tomer, Gitit, Mamula, Petar, Kay, Marsha H., Kerzner, Benny, Oliva–Hemker, Maria, Kappelman, Michael D., Saeed, Shehzad A., Hyams, Jeffrey S., and LeLeiko, Neal S.

Published
2010
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5. Partially Hydrolysed Whey-Based Infant Formula Improves Skin Barrier Function

Author

Holvoet, Sébastien, primary, Nutten, Sophie, additional, Dupuis, Lénaïck, additional, Donnicola, Dominique, additional, Bourdeau, Tristan, additional, Hughes-Formella, Betsy, additional, Simon, Dagmar, additional, Simon, Hans-Uwe, additional, Carvalho, Ryan S., additional, Spergel, Jonathan M., additional, Koletzko, Sibylle, additional, and Blanchard, Carine, additional

Published
2021
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11. Pulmonary manifestations in a pediatric patient with ulcerative colitis: a case report

Author

Carvalho Ryan S, Wilson Lindsay, and Cuffari Carmen

Subjects
Medicine
Abstract

Abstract Introduction Although respiratory involvement has been described in patients with IBD, well-defined interstitial lung disease has not been reported, especially among children with ulcerative colitis. Case presentation Herein, we present a case of an adolescent female with ulcerative colitis and extra-intestinal complications involving the lungs that were effectively treated with anti-metabolite therapy. Conclusion Children with UC may manifest either interstitial or large airway pulmonary involvement. All children with suspected lung involvement should be screened for tuberculosis prior to starting immunosuppressive therapy.

Published
2008
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12. Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity

Author

Dotson, Jennifer L, primary, Hyams, Jeffrey S, additional, Markowitz, James, additional, LeLeiko, Neal S, additional, Mack, David R, additional, Evans, Jonathan S, additional, Pfefferkorn, Marian D, additional, Griffiths, Anne M, additional, Otley, Anthony R, additional, Bousvaros, Athos, additional, Kugathasan, Subra, additional, Rosh, Joel R, additional, Keljo, David, additional, Carvalho, Ryan S, additional, Tomer, Gitit, additional, Mamula, Petar, additional, Kay, Marsha H, additional, Kerzner, Benny, additional, Oliva-Hemker, Maria, additional, Langton, Christine R, additional, and Crandall, Wallace, additional

Published
2010
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13. W1187 Outcome Following Infliximab Therapy in Pediatric Patients with Ulcerative Colitis: Results from a Multicenter Study

Author

Hyams, Jeffrey S., primary, Lerer, Trudy, additional, Griffiths, Anne M., additional, Evans, Jonathan S., additional, Carvalho, Ryan S., additional, Otley, Anthony R., additional, Bousvaros, Athos, additional, Mack, David R., additional, Pfefferkorn, Marian D., additional, Rosh, Joel R., additional, Kay, Marsha H., additional, Crandall, Wallace, additional, Tomer, Gitit, additional, Leleiko, Neal S., additional, Keljo, David J., additional, and Markowitz, James, additional

Published
2009
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14. W1198 Medication Use and Disease Characteristics in Early-Onset and Later-Onset Pediatric Inflammatory Bowel Disease (IBD)

Author

Oliva-Hemker, Maria, primary, Hutfless, Susan, additional, Hyams, Jeffrey S., additional, Langton, Christine R., additional, Lerer, Trudy, additional, Bousvaros, Athos, additional, Carvalho, Ryan S., additional, Crandall, Wallace, additional, Evans, Jonathan, additional, Griffiths, Anne M., additional, Kay, Marsha H., additional, Keljo, David J., additional, Kugathasan, Subra, additional, LeLeiko, Neal S., additional, Mack, David R., additional, Mamula, Petar, additional, Otley, Anthony R., additional, Pfefferkorn, Marian D., additional, Rosh, Joel R., additional, and Markowitz, James, additional

Published
2009
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15. W1196 Utilization and Effect of Methotrexate in the Treatment of Pediatric Crohn's Disease: A Multi-Center Experience

Author

Rosh, Joel R., primary, Mohamed, Alliya, additional, Markowitz, James, additional, Mack, David R., additional, Griffiths, Anne M., additional, Bousvaros, Athos, additional, Kay, Marsha H., additional, Mamula, Petar, additional, Pfefferkorn, Marian D., additional, Carvalho, Ryan S., additional, Kugathasan, Subra, additional, Keljo, David J., additional, Tomer, Gitit, additional, LeLeiko, Neal S., additional, Oliva-Hemker, Maria, additional, Lerer, Trudy, additional, Hyams, Jeffrey S., additional, and Crandall, Wallace, additional

Published
2009
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16. W1189 Indeterminate Colitis (IC) in Children: A Two-Year Follow-Up

Author

Lora, Melissa, primary, Pfefferkorn, Marian D., additional, Langton, Christine R., additional, Markowitz, James, additional, Evans, Jonathan, additional, Rosh, Joel R., additional, Kay, Marsha H., additional, Crandall, Wallace, additional, Keljo, David J., additional, Otley, Anthony R., additional, Kugathasan, Subra, additional, Carvalho, Ryan S., additional, Oliva-Hemker, Maria, additional, Bousvaros, Athos, additional, Leleiko, Neal S., additional, Mack, David R., additional, Griffiths, Anne M., additional, and Hyams, Jeffrey S., additional

Published
2009
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17. W1188 Growth in Pediatric Patients with IBD Treated with Infliximab or 6-Mercaptopurine/Azathioprine

Author

Keljo, David J., primary, Markowitz, James, additional, Langton, Christine R., additional, Lerer, Trudy, additional, Bousvaros, Athos, additional, Carvalho, Ryan S., additional, Crandall, Wallace, additional, Evans, Jonathan, additional, Griffiths, Anne M., additional, Kay, Marsha H., additional, Kugathasan, Subra, additional, LeLeiko, Neal S., additional, Mack, David R., additional, Oliva-Hemker, Maria, additional, Otley, Anthony R., additional, Pfefferkorn, Marian D., additional, Rosh, Joel R., additional, Tomer, Gitit, additional, and Hyams, Jeffrey S., additional

Published
2009
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18. 154 Inter-Center Variation in the Clinical Outcomes of Pediatric Crohn's Disease

Author

Kappelman, Michael D., primary, Markowitz, James, additional, Bousvaros, Athos, additional, Carvalho, Ryan S., additional, Crandall, Wallace, additional, Evans, Jonathan, additional, Galanko, Joseph A., additional, Griffiths, Anne M., additional, Keljo, David J., additional, Kugathasan, Subra, additional, Langton, Christine R., additional, Leleiko, Neal S., additional, Mack, David R., additional, Otley, Anthony R., additional, Pfefferkorn, Marian D., additional, Rosh, Joel R., additional, Tomer, Gitit, additional, and Hyams, Jeffrey S., additional

Published
2009
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19. W1127 Clinical Outcome Following Immunomodulator Therapy in Pediatric Ulcerative Colitis (UC): Results from a Prospective Multicenter Inception Cohort

Author

Bousvaros, Athos, primary, Lerer, Trudy, additional, Markowitz, James, additional, Griffiths, Anne M., additional, Keljo, David, additional, LeLeiko, Neal S., additional, Mack, David R., additional, Evans, Jonathan, additional, Pfefferkorn, Marian D., additional, Otley, Anthony R., additional, Kugathasan, Subra, additional, Rosh, Joel R., additional, Carvalho, Ryan S., additional, Moyer, M. Susan, additional, Kay, Marsha H., additional, Mamula, Petar, additional, Kerzner, Benny, additional, Crandall, Wallace, additional, and Hyams, Jeffrey S., additional

Published
2008
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20. W1219 Retrospective Evaluation of the Safety and Effect of Adalimumab Therapy (Reseat) in Pediatric Crohn's Disease

Author

Rosh, Joel R., primary, Lerer, Trudy, additional, Markowitz, James, additional, Goli, Sridhar R., additional, Mamula, Petar, additional, Noe, Joshua D., additional, Pfefferkorn, Marian D., additional, Kelleher, Kathleen T., additional, Griffiths, Anne M., additional, Kugathasan, Subra, additional, Keljo, David, additional, Oliva-Hemker, Maria, additional, Crandall, Wallace, additional, Carvalho, Ryan S., additional, Mack, David R., additional, and Hyams, Jeffrey S., additional

Published
2008
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21. W1128 Extra-Intestinal Manifestations of Pediatric Inflammatory Bowel Disease

Author

Dotson, Jennifer L., primary, Hyams, Jeffrey S., additional, Markowitz, James, additional, LeLeiko, Neal S., additional, Mack, David R., additional, Evans, Jonathan, additional, Pfefferkorn, Marian D., additional, Griffiths, Anne M., additional, Otley, Anthony R., additional, Bousvaros, Athos, additional, Kugathasan, Subra, additional, Rosh, Joel R., additional, Keljo, David, additional, Carvalho, Ryan S., additional, Moyer, M. Susan, additional, Mamula, Petar, additional, Kay, Marsha H., additional, Kerzner, Benny, additional, Langton, Christine R., additional, and Crandall, Wallace, additional

Published
2008
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22. 924 Long-Term Outcome Following Infliximab Therapy in Pediatric Patients with Crohn Disease: Results from a Multicenter Study

Author

Hyams, Jeffrey S., primary, Lerer, Trudy, additional, Pfefferkorn, Marian D., additional, Kugathasan, Subra, additional, Evans, Jonathan, additional, Otley, Anthony R., additional, Griffiths, Anne M., additional, Carvalho, Ryan S., additional, Mack, David R., additional, Bousvaros, Athos, additional, Rosh, Joel R., additional, Mamula, Petar, additional, Moyer, M. Susan, additional, Kay, Marsha H., additional, Crandall, Wallace, additional, Oliva-Hemker, Maria, additional, Keljo, David, additional, LeLeiko, Neal S., additional, and Markowitz, James, additional

Published
2008
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23. W1225 Budesonide Is An Effective But Underutilized Therapy in Pediatric Crohn Disease

Author

Otley, Anthony R., primary, Markowitz, James, additional, LeLeiko, Neal S., additional, Griffiths, Anne M., additional, Crandall, Wallace, additional, Kugathasan, Subra, additional, Oliva-Hemker, Maria, additional, Bousvaros, Athos, additional, Pfefferkorn, Marian D., additional, Mack, David R., additional, Evans, Jonathan, additional, Rosh, Joel R., additional, Keljo, David, additional, Mamula, Petar, additional, Moyer, M. Susan, additional, Carvalho, Ryan S., additional, Kerzner, Benny, additional, Kay, Marsha H., additional, Lerer, Trudy, additional, and Hyams, Jeffrey S., additional

Published
2008
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24. T1164 Surgery in a Prospectively Followed Cohort of Pediatric Patients with Crohn's Disease (CD)

Author

Schaefer, Marc E., primary, Hyams, Jeffrey S., additional, Markowitz, James, additional, Mack, David R., additional, Griffiths, Anne M., additional, Otley, Anthony R., additional, Bousvaros, Athos, additional, Keljo, David, additional, Evans, Jonathan, additional, Pfefferkorn, Marian D., additional, Kay, Marsha H., additional, Mamula, Petar, additional, Rosh, Joel R., additional, Carvalho, Ryan S., additional, Kugathasan, Subra, additional, Moyer, M. Susan, additional, Crandall, Wallace, additional, and LeLeiko, Neal S., additional

Published
2008
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27. Human Milk Bioactives: Future Perspective.

Author

Finn KL, Kineman BD, Czerkies LA, and Carvalho RS

Subjects
Animals, Breast Feeding, Female, Humans, Infant, Milk chemistry, Oligosaccharides analysis, Prebiotics, Gastrointestinal Microbiome, Milk, Human chemistry
Abstract

Human milk is a dynamic, complex fluid that offers much more than nutrition to infants. The macronutrient content of human milk has been well characterized and described. However, human milk is not a simple matrix of protein, carbohydrate, fat, and micronutrients. The National Institutes of Health have defined bioactives in food as elements that "affect biological processes or substrates and hence have an impact on body function or condition and ultimately health." Bioactives are cells, anti-infectious and anti-inflammatory agents, growth factors, and prebiotics that are naturally present in human milk. They may explain the differences in health outcomes observed between breastfed and non-breastfed infants. They influence the development of the immune and gastrointestinal systems, gut microbiota, neurodevelopment, metabolic health, and protection against infection. Human milk oligosaccharides are one bioactive that have been an increasingly popular area of research. This review provides a broad overview of some bioactive components that positively affect the immune system and touches on certain well-known growth factors present in human milk. Future research will look at the interplay of the multitude of bioactive components in human milk as a biological system and beyond singular compounds., (© 2022 S. Karger AG, Basel.)

Published
2021
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