58 results on '"Carvalho FO"'
Search Results
2. Risk factors for atherosclerosis in an elderly out patient population in the City of São Paulo
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Yolanda Maria Garcia Alencar, Eurico Thomaz de Carvalho Fº, Sérgio Márcio Pacheco Paschoal, José Antonio Esper Curiati, Chiu Ping Wong, and Júlio Litvoc
- Subjects
risk factors ,atherosclerosis ,elderly ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
OBJECTIVE: To analyze in out clinic elderly patients of both sexes for the prevalence of risk factors for atherosclerosis and study their association with the complications of atherosclerosis. METHODS: Five hundred and sixteen outpatients, 152 men and 364 women, 60 years or older, were studied. The prevalences of hypertension, dyslipidemia, diabetes mellitus, cigarette smoking and obesity were determined in both sexes and compared using the chi-square test. The association between these factors and the presence of atherosclerotic complications was analyzed by logistic regression. RESULTS: The comparative analysis of the factors in both sexes showed that hypertension, total cholesterol > or = 240mg/dL, LDL-cholesterol > or = 160mg/dL, and body mass index >27.5 were more frequent among women, but HDL-cholesterol or = 250mg/dL and diabetes mellitus. After adjustment of the variables in the regression model, we observed that in the total of elderly patients, risk factors for complications of atherosclerosis were: triglycerides > or = 250mg/dL, hypertension, and male sex. Among men, the risk factors were: LDL-cholesterol > or = 160mg/dL, diabetes mellitus, HDL-cholesterol or = 250mg/dL and hypertension. CONCLUSION: The results showed that, in the elderly, the risk factors for atherosclerosis persist, but with different behaviors between men and women. The study suggests that the relative importance of the risk factors can change with the aging process.
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- 2000
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3. Insuficiência cardíaca diastólica no idoso
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Eurico Thomaz de Carvalho Fº, Romeu Rodrigues de Souza, and José Luiz Figueira
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 1998
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4. Insuficiência cardíaca diastólica no idoso
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José Luiz Figueira, Eurico Thomaz de Carvalho Fº, and Romeu Rodrigues de Souza
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medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,business.industry ,lcsh:RC666-701 ,Internal medicine ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Published
- 1998
5. Signal to cut-off (S/CO) ratio and detection of HCV genotype 1 by real-time PCR one-step method: is there any direct relationship?
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Albertoni, Guilherme, primary, Arnoni, CP, additional, Araújo, PRB, additional, Carvalho, FO, additional, and Barreto, JA, additional
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- 2010
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6. Risk factors for atherosclerosis in an elderly out patient population in the City of São Paulo
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Alencar, Yolanda Maria Garcia, primary, Carvalho Fº, Eurico Thomaz de, additional, Paschoal, Sérgio Márcio Pacheco, additional, Curiati, José Antonio Esper, additional, Wong, Chiu Ping, additional, and Litvoc, Júlio, additional
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- 2000
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7. Insuficiência cardíaca diastólica no idoso
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Carvalho Fº, Eurico Thomaz de, primary, Souza, Romeu Rodrigues de, additional, and Figueira, José Luiz, additional
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- 1998
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8. High prevalence of celiac disease in Brazilian blood donor volunteers based on screening by IgA antitissue transglutaminase antibody.
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Oliveira RP, Sdepanian VL, Barreto JA, Cortez AJP, Carvalho FO, Bordin JO, de Camargo Soares MA, da Silva Patrício FR, Kawakami E, de Morais MB, and Fagundes-Neto U
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- 2007
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9. Effects of excess concentrations of aluminum, chloride and manganese in the nutrient solution on growth and composition of two soybean cultivars
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I.S. Machado, H.C. Carvalho Fº, F.A.M. Solis, H.J. Rochelle, E. de Freitas, J.M. Fernandes, I.S. Ribeiro, I. Andrioli, J. Kaminski, Santos G.A, F. Andreola, João Edson Carvalho, J.A. Jorge, F.S. Cavalcante, H.M. Cabrini, G. Bertoloti, I.E. Eimori, Eurípedes Malavolta, and I.M.S. Vieira
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Horticulture ,Nutrient solution ,chemistry ,Crop production ,General Health Professions ,Botany ,chemistry.chemical_element ,Composition (visual arts) ,Dry matter ,Phytotoxicity ,Manganese ,Cultivar - Abstract
Dois cultivares de soja, Santa Rosa e UFV-1, foram cultivados em solução nutritiva na presença de excesso de alumínio, cloro e manganês. Além de provocar o aparecimento de sintomas foliares (cloro e manganês) ou radiculares (alumínio), os elementos em excesso causaram diminuições no crescimento e impediram a produção de vagens. A análise mineral das folhas mostrou a influência dos tratamentos na composição do tecido. Two soybean cultivars, Santa Rosa and FV-1, were grown in nutrient solution in the presence of high concentrations of Al (24 ppm), CI (1750 ppm) and Mn (25 ppm). Observations, measurements and chemical analyses allowed for the following conclusions to be drawn: (1) symptoms of toxicity are in agreement with those described in the literatura; (2) the detrimental effect obeyed the decreasing order - Mn Al CI; (3) dry matter production by the variety UFV - 1 was relatively more affected by the treatments; (4) leaf analyses do not provide a reliable indication of the sensitivity of the two varieties to the high levels of the three elements in the substrate; (5) Ca/Al ratio in the roots keeps a good relationship with the relative tolerance of the two cultivas to excess Al in the medium.
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- 1980
10. Efeitos dos excessos de alumínio, cloro e manganês em dois cultivares de soja (Glycine max (L.) Merrill)
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Malavolta, E., Freitas Jr., E. de, Andreola, F., Cavalcante, F.S., Solis, F.A.M., Fernandes, J.M., Santos, G.A, Bertoloti, G., Cabrini, H.M., Carvalho Fº, H.C., Rochelle, H.J., Vieira, I.M.S., Machado, I.S., Eimori, I.E., Andrioli, I., Ribeiro, I.S., Kaminski, J., Jorge, J.A., and Carvalho, J.E.R.
- Abstract
Two soybean cultivars, Santa Rosa and FV-1, were grown in nutrient solution in the presence of high concentrations of Al (24 ppm), CI (1750 ppm) and Mn (25 ppm). Observations, measurements and chemical analyses allowed for the following conclusions to be drawn: (1) symptoms of toxicity are in agreement with those described in the literatura; (2) the detrimental effect obeyed the decreasing order - Mn Al CI; (3) dry matter production by the variety UFV - 1 was relatively more affected by the treatments; (4) leaf analyses do not provide a reliable indication of the sensitivity of the two varieties to the high levels of the three elements in the substrate; (5) Ca/Al ratio in the roots keeps a good relationship with the relative tolerance of the two cultivas to excess Al in the medium. Dois cultivares de soja, Santa Rosa e UFV-1, foram cultivados em solução nutritiva na presença de excesso de alumínio, cloro e manganês. Além de provocar o aparecimento de sintomas foliares (cloro e manganês) ou radiculares (alumínio), os elementos em excesso causaram diminuições no crescimento e impediram a produção de vagens. A análise mineral das folhas mostrou a influência dos tratamentos na composição do tecido.
- Published
- 1980
11. Monoarticulars exercises for the weight training.
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Dossantos DC, Moraes ICM, Mello F, de Oliveira KJN, Carvalho FO Jr., and Gulmaraes M
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- 2008
12. Association between the environment for physical activity in public schools and childhood obesity: a view in the light of complex systems.
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Souza Filho AN, Bezerra TA, Bandeira PFR, Cabral LG, Brito A, Guerra PH, Martins CML, and Carvalho FO
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- Humans, Child, Male, Cross-Sectional Studies, Female, Sex Factors, Age Factors, Overweight epidemiology, Schools, Pediatric Obesity epidemiology, Exercise physiology, Body Mass Index, Physical Education and Training
- Abstract
This article aims to analyse the relationship between physical activity (PA) environment at schools, sex, age, and obesity in children, using a network approach. This is a cross-sectional study, with 1,200 children (8.1±1.0 years old) from eight public schools in the same municipality. Weight and height measurements were assessed to calculate the Body Mass Index (BMI) and classified as healthier weight or overweight. To assess the PA environment at school, a interview with the school´s manager was conducted. The association between the PA environment at school and obesity was tested using a Network Analysis performed on the Jasp software. Positive associations between BMI and Physical Education classes (0.847), physical education teacher (0.349), break duration (0.564), and indoor sports court (0.662) were observed. Negative associations were seen with sex (-0.212) age (-0.387), extracurricular PA (-0.492), and playground (-0.557). Additionally, the centrality indicators highlighted extracurricular PA (1.789) as the variables with the highest betweenness values, and BMI with the highest closeness (2.239) and strength (1.230) values. Extracurricular PA and the presence of playgrounds in school´s environment are associated with healthier weight in low-income children.
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- 2024
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13. Effects of a multicomponent intervention on cardiovascular risk factors in overweight children: a randomized clinical trial in light of complex systems.
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Bezerra TA, Souza Filho AN, Pessoa MLF, Ribeiro Bandeira PF, Cabral LGA, Moraes JFVN, Martins CML, and Carvalho FO
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- Child, Humans, Body Mass Index, Risk Factors, Heart Disease Risk Factors, Overweight psychology, Cardiovascular Diseases prevention & control
- Abstract
Analyzing the effects of interventions from a theoretical and statistical perspective that allows understanding these dynamic relationships of obesity etiology can be a more efficient and innovative way of understanding the phenomenon's complexity. Thus, we aimed to analyze the pattern of cardiovascular risk factors between-participants, and the effects within-participants of a multidisciplinary intervention on cardiovascular risk factors in overweight children. This is a randomized clinical trial, and 41 participated in this study. A multicomponent intervention (physical activities, nutritional and psychological counseling) was performed for 10 weeks. Anthropometric and hemodynamics measurements, lipid and glucose profile, cardiorespiratory fitness, and left ventricular mass were evaluated. A network analysis was done. Considering patterns in the network at baseline, WC, WHR, BMI, and Fat were the main variables for cardiovascular risks. Group was the most critical variable in the within-participant network. Participating in a multicomponent intervention and decreasing body fat promoted beneficial cardiovascular factors.
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- 2023
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14. Effectiveness of physical therapy interventions in women with dyspareunia: a systematic review and meta-analysis.
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Fernández-Pérez P, Leirós-Rodríguez R, Marqués-Sánchez MP, Martínez-Fernández MC, de Carvalho FO, and Maciel LYS
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- Humans, Female, Quality of Life, Physical Therapy Modalities, Pain, Dyspareunia therapy, Transcutaneous Electric Nerve Stimulation
- Abstract
Background: Dyspareunia is defined as the occurrence of pain during or after sexual intercourse, which directly affects physical, sexual, and mental health. This condition can lead to depression, anxiety, and low self-esteem in women who experience it., Objectives: The aim of this research was to evaluate the effectiveness of physical therapy interventions for the treatment of female dyspareunia., Design: A systematic review and meta-analysis was conducted., Method: Search of publications was conducted in Scopus, Medline, Pubmed, Cinahl and Web of Science. Treatment effects were defined as standardized mean difference and their 95% confidence intervals. Statistical heterogeneity was assessed using Crohan's Q test and quantified using the I
2 index., Results: Of the 19 articles selected, six applied multimodal physiotherapy treatments; five, electrotherapy; three, Thiele's massage; two, interdisciplinary interventions or pelvic floor muscle training; and one, extracorporeal shockwave therapy. The meta-analysis showed significant results for the variables pain and quality of life with the interventions based on electrotherapy and electrotherapy combined with pelvic floor muscle training. These interventions did not show significant results for the improvement of sexual function., Conclusions: Physiotherapy techniques are effective and procedures have been identified with reliable results in improving pain and quality of life in patients with dyspareunia. One of the most important aspects is the strengthening of the perineal musculature and the application of Transcutaneous Electrical Nerve Stimulation. Furthermore, manual trigger point release therapy and Thiele massage, optimize and guarantee the reduction of pain intensity., Prospero Registration: CRD42021236155., (© 2023. The Author(s).)- Published
- 2023
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15. Dynamics of SARS-CoV-2 seroprevalence during the first year of the COVID-19 pandemic in the Northeast region of Brazil.
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de Souza Araújo AA, Quintans-Júnior LJ, Heimfarth L, Schimieguel DM, Corrêa CB, de Moura TR, Cavalcante RCM, Grespan R, de Souza Siqueira Quintans J, Dos Santos DM, da Silva DN, de Oliveira YLM, de Franca MNF, da Conceição Silva M, de Sá DLF, de Carvalho FO, de Souza MF, de Oliveira Góes MA, Santos VS, and Martins-Filho PR
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- Adult, Aged, Female, Humans, Pandemics, Brazil, Seroepidemiologic Studies, Antibodies, Viral, SARS-CoV-2, COVID-19
- Abstract
In this household-based seroepidemiological survey, we analyzed the dynamics of SARS-CoV-2 seroprevalence during the first year of the COVID-19 pandemic in Sergipe State, Northeast Brazil, the poorest region of the country. A total of 16,547 individuals were tested using a rapid IgM-IgG antibody test and fluorescence immunoassay (FIA). Seroprevalence rates were presented according to age, sex, and geographic region. A comparative analysis was performed between the results obtained in July 2020 (peak of the first wave), August - November 2020 (end of the first wave), and February - March 2021 (beginning of the second wave). Seroprevalence rates in the three phases were estimated at 9.3% (95% CI 8.5-10.1), 12.0% (95% CI 11.2-12.9) and 15.4% (95% CI 14.5-16.4). At the end of the first wave, there was a rise in seroprevalence in the countryside (p < 0.001). At the beginning of the second wave, we found an increase in seroprevalence among women (p < 0.001), adults aged 20 to 59 years (p < 0.001), and the elderly (p < 0.001). In this phase, we found an increase in estimates both in metropolitan areas and in the countryside (p < 0.001). This study showed an increase in SARS-CoV-2 seroprevalence over the first year of the pandemic, with approximately one in six people having anti-SARS-CoV-2 antibodies at the beginning of the second wave of COVID-19. Furthermore, our results suggest a rapid spread of COVID-19 from metropolitan areas to the countryside during the first months of the pandemic.
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- 2023
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16. Efficacy of percutaneous electrolysis for the treatment of tendinopathies: A systematic review and meta-analysis.
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Asensio-Olea L, Leirós-Rodríguez R, Marqués-Sánchez MP, de Carvalho FO, and Maciel LYS
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- Humans, Treatment Outcome, Pain, Electrolysis methods, Exercise Therapy methods, Tendinopathy therapy
- Abstract
Objective: To evaluate the efficacy of percutaneous electrolysis for the treatment of patients with tendinopathies., Data Sources: A systematic search of publications was conducted in Pubmed, Cinahl, Medline, Scopus and Web of Science., Methods: The Oxford 2011 Levels of Evidence and the Jadad scale were used to assess the quality of studies. The mean and standard deviation were obtained for each study group and used to calculate the effect size. The DerSimonian and Laird method was used to develop a random-effects model., Results: Of the 14 articles, four applied percutaneous electrolysis to the knee, three to the shoulder, three to the elbow, two to the hip and two to the ankle and foot. A meta-analysis on intensity of pain (evaluated with algometer and the Visual Analogue Scale) was performed on studies comparing percutaneous electrolysis with a control group, indicating that the groups treated with percutaneous electrolysis had better results ( p = 0.01). Although percutaneous electrolysis did not overcome the analgesic effect achieved by corticosteroid injections., Conclusions: The percutaneous electrolysis is effective for the treatment of tendinopathies. The combination of this technique with eccentric training has proven to be one of the most effective treatments to date for improving pain. PROSPERO Registration: CRD42021230005.
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- 2023
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17. Risk factors for blood transfusion and its prognostic implications in curative gastrectomy for gastric cancer.
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Kawakami LE, Bonomi PB, Pereira MA, Carvalho FO, Ribeiro U Jr, Zilberstein B, Sampaio LR, Carneiro-D'Albuquerque LA, and Ramos MFKP
- Abstract
Background: Gastric cancer (GC) is still a prevalent neoplasm around the world and its main treatment modality is surgical resection. The need for perioperative blood transfusions is frequent, and there is a long-lasting debate regarding its impact on survival., Aim: To evaluate the factors related to the risk of receiving red blood cell (RBC) transfusion and its influence on surgical and survival outcomes of patients with GC., Methods: Patients who underwent curative resection for primary gastric adenocarcinoma at our Institute between 2009 and 2021 were retrospectively evaluated. Clinicopathological and surgical characteristics data were collected. The patients were divided into transfusion and non-transfusion groups for analysis., Results: A total of 718 patients were included, and 189 (26.3%) patients received perioperative RBC transfusion (23 intraoperatively, 133 postoperatively, and 33 in both periods). Patients in the RBC transfusions group were older ( P < 0.001), and had more comorbidities ( P = 0.014), American Society of Anesthesiologists classification III/IV ( P < 0.001), and lower preoperative hemoglobin ( P < 0.001) and albumin levels ( P < 0.001). Larger tumors ( P < 0.001) and advanced tumor node metastasis stage ( P < 0.001) were also associated with the RBC transfusion group. The rates of postoperative complications (POC) and 30-d and 90-d mortality were significantly higher in the RBC transfusion group than in the non-transfusion group. Lower hemoglobin and albumin levels, total gastrectomy, open surgery, and the occurrence of POC were factors associated with the RBC transfusion. Survival analysis demonstrated that the RBC transfusions group had worse disease-free survival (DFS) and overall survival (OS) compared with patients who did not receive transfusion ( P < 0.001 for both). In multivariate analysis, RBC transfusion, major POC, pT3/T4 category, pN+, D1 lymphadenectomy, and total gastrectomy were independent risk factors related to worse DFS and OS., Conclusion: Perioperative RBC transfusion is associated with worse clinical conditions and more advanced tumors. Further, it is an independent factor related to worse survival in the curative intent gastrectomy setting., Competing Interests: Conflict-of-interest statement: The authors declare no conflict of interest for this article., (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
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- 2023
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18. Prevalence of SARS-CoV-2 infection among urban cleaning and solid waste management workers during transmission of the Omicron variant in Brazil.
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Martins-Filho PR, Dos Santos JTDC, Rezende MS, de Carvalho FO, Dos Reis ÉS, Barboza WS, Cavalcante TF, Dos Santos CA, Quintans-Júnior LJ, Grespan R, Corrêa CB, de Moura TR, Schimieguel DM, Quintans JSS, and de Souza Araújo AA
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- Humans, SARS-CoV-2, Brazil epidemiology, Prevalence, RNA, Viral, COVID-19 epidemiology, COVID-19 prevention & control, Waste Management
- Abstract
This study estimated the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in urban cleaning and solid waste management workers during the transmission of the Omicron variant in one of the poorest regions of Brazil (the state of Sergipe). Nasopharyngeal swabs were collected from 494 workers, and the presence of SARS-CoV-2 RNA was tested by quantitative reverse-transcriptase polymerase chain reaction. Data on socio-demographic characteristics, comorbidities, vaccination status, mask use, and use of public transport to commute to the workplace were collected. The prevalence with a 95% confidence interval (CI) was calculated from the proportion of SARS-CoV-2 positive cases among the total number of individuals tested. The prevalence ratio (PR) with a 95% CI was the measure of association used to evaluate the relationship between SARS-CoV-2 infection and the exposure variables. The prevalence of SARS-CoV-2 infection was 22.5% (95% CI, 19.0 to 26.4). Individuals under the age of 40 had a higher prevalence of infection (PR, 1.53; 95% CI, 1.03 to 2.30) as well as those who did not believe in the protective effect of vaccines (PR, 1.78; 95% CI, 1.05 to 2.89). Our results indicate the need for better guidance on preventive measures against coronavirus disease 2019 among urban cleaning and solid waste management workers.
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- 2023
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19. Massage for pain relief in newborns submitted to puncture: systematic review.
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Costa TMS, Oliveira EDS, Silva BVSD, Melo EBB, Carvalho FO, Duarte FHDS, Dantas RAN, and Dantas DV
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- Infant, Newborn, Humans, Punctures adverse effects, Pain, Databases, Factual, Massage, Pain Management
- Abstract
Objective: To analyze in the scientific literature the effects of massage on pain relief in newborns submitted to puncture., Method: Systematic review with meta-analysis performed in October 2020, using PubMed, Web of Science, CINAHL, Scopus, Cochrane and Gale databases. Studies without time frame were included, which used massage as the main technique for relieving neonatal pain during puncture. Data were extracted using standardized forms and the synthesis of results occurred in a descriptive way., Results: From the 12 studies included, massage was effective in pain relief in 83.3% of the studies. The comparative meta-analysis of massage versus routine care that assessed duration of crying obtained a statistically significant result (p = 0.0002; 95% CI -85.51 to -27.09)., Conclusion: Massage contributes to neonatal pain relief by reducing pain score and reducing crying time in newborns submitted to puncture.
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- 2022
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20. Limited Mobility to the Bed Reduces the Chances of Discharge and Increases the Chances of Death in the ICU.
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Dos Santos Moraes TL, de Farias JMF, Rezende BS, de Carvalho FO, Santiago MS, Porto ES, Doria FM, Santana KCS, Gomes MV, Leite VS, Madruga RETTA, Dos Santos Maciel LY, Andrade JD, de Farias Neto JP, Aidar FJ, and da Silva Junior WM
- Abstract
Background: Progressive mobility in the ICU has been recommended; however, the definitions of low, moderate, and high mobility in the ICU still diverge between studies. Therefore, our objective was to classify the mobility of the sample from verticalization and active withdrawal from the bed, and from that, to analyze the chances of discharge, death, and readmission to the ICU., Materials and Methods: This is an observational and retrospective study that consults the medical records of individuals admitted to the ICU of the University Hospital of Sergipe (HU/SE) between August 2017 and August 2018. Mobility level was classified based on the Intensive Care Unit Mobility Scale (IMS)., Results: A total of 121 individuals were included. The mean age was 61.45 ± 16.45, being 53.7% female. Of these, 28 (23.1%) had low mobility, 33 (27.3%) had moderate mobility, and 60 (49.6%) had high mobility. Individuals with low mobility were 45 times more likely to die (OR = 45.3; 95% CI = 3.23-636.3) and 88 times less likely to be discharged from the ICU (OR = 0.22; 95% CI = 0.002-0.30)., Conclusion: Those who evolved with low mobility had a higher chance of death and a lower chance of discharge from the ICU. Moderate and high mobility were not associated with the investigated outcomes.
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- 2021
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21. Would carvacrol be a supporting treatment option effective in minimizing the deleterious effects of COVID-19?
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de Carvalho FO, Silva JPR, Silva ÉR, de Albuquerque Júnior RLC, Nunes PS, and de Souza Araújo AA
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- Animals, Anti-Infective Agents pharmacology, Anti-Infective Agents therapeutic use, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents therapeutic use, Antioxidants pharmacology, COVID-19 immunology, Cymenes pharmacology, Cytokine Release Syndrome drug therapy, Cytokine Release Syndrome immunology, Cytokine Release Syndrome metabolism, Humans, Inflammation Mediators antagonists & inhibitors, Inflammation Mediators immunology, Inflammation Mediators metabolism, Antioxidants therapeutic use, COVID-19 metabolism, Cymenes therapeutic use, COVID-19 Drug Treatment
- Abstract
The pathophysiological process of the disease, Covid-19, is mediated by innate immunity, with the presence of macrophages responsible for secreting type 1 and 6 interleukins (IL), tumor necrosis factor (TNF) leading to dilation of endothelial cells with a consequent increase in capillary permeability. The treatment of this disease has been much discussed, but the variability in the clinical picture, the difficulties for diagnosis and treatment, especially of those patients who have the most severe clinical condition of the disease. Immunization is an effective tool for controlling the spread and overload of health services, but its effectiveness involves high investments in the acquisition of inputs, development of vaccines, and logistics of storage and distribution. These factors can be obstacles for countries with lower economic, technological, and infrastructure indexes. Reflecting on these difficulties, we raised the possibility of adjuvant therapies with imminent research feasibility, as is the case with the use of carvacrol, a monoterpenic phenol whose has biological properties that serve as a barrier to processes mediated by free radicals, such as irritation and inflammation, due to its antioxidant action. Many authors highlighted the activity of carvacrol as a potent suppressor of COX-2 expression minimizing the acute inflammatory process, decreasing the release of some pro-inflammatory mediators such as IL-1β, TNF-α, PGE2. Anyway, the benefits of carvacrol are numerous and the therapeutic possibilities too. With this description, the question arises: would carvacrol be a supporting treatment option, effective in minimizing the deleterious effects of Covid-19? There is still a lot to discover and research., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2021
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22. Monoterpenes and their derivatives as agents for cardiovascular disease management: A systematic review and meta-analysis.
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Silva EAP, Santos DM, de Carvalho FO, Menezes IAC, Barreto AS, Souza DS, Quintans-Júnior LJ, and Santos MRV
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- Animals, Disease Models, Animal, Humans, Hypertension drug therapy, Myocardial Infarction drug therapy, Oils, Volatile chemistry, Plants chemistry, Cardiovascular Agents pharmacology, Cardiovascular Diseases drug therapy, Monoterpenes pharmacology
- Abstract
Background: Monoterpenes are one of the most studied plant's secondary metabolites, they are found abundantly in essential oils of aromatic plants. They also have a great range of pharmacological properties, such as antihypertensive, bradycardic, antiarrhythmic and hypotensive. In the face of the burden caused by cardiovascular disease (CVDs) worldwide, studies using monoterpenes to assess their cardiovascular effects have increased over the years., Purpose: This systematic review aimed to summarize the use of monoterpenes in animal models of any CVDs., Methods: PubMed, SCOPUS, LILACS and Web of Science databases were used to search for articles that used monoterpenes, in any type of administration, to treat or prevent CVDs in animal models. The PRISMA guidelines were followed. Two independent researchers extracted main characteristics of studies, methods and outcomes. Data obtained were analyzed qualitatively and quantitatively., Results: At the ending of the search process, 33 articles were selected for the systematic review. Of these, 17 articles were included in the meta-analysis. A total of 16 different monoterpenes were found for the treatment of hypertension, myocardial infarction, pulmonary hypertension, cardiac hypertrophy and arrhythmia. The main actions include hypotension, bradycardia, vasodilatation, antiarrhythmic, and antioxidant and antiapoptotic properties. From our data, it can be suggested that monoterpenes may be a significant source for new drug development. However, there is still a need to apply these knowledge into clinical research and a long path to pursue before putting them in the market., Conclusion: The variability of cardiovascular effects demonstrated by the monoterpenes highlighted them as a promising candidates for treatment or prevention of CVDs. Nevertheless, studies that investigate their biological sites of action needs to be further encouraged., (Copyright © 2020 Elsevier GmbH. All rights reserved.)
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- 2021
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23. Diagnostic Accuracy of Serum Hyaluronan for Detecting HCV Infection and Liver Fibrosis in Asymptomatic Blood Donors.
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Rodart IF, Pares MM, Mendes A, Accardo CM, Martins JRM, Silva CB, Carvalho FO, Barreto JA, Reis MG, Tersariol ILS, and Nader HB
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- Adult, Enzyme-Linked Immunosorbent Assay, Female, Genotype, Hepacivirus genetics, Hepatitis C genetics, Humans, Liver Cirrhosis genetics, Male, Middle Aged, Blood Donors, Hepacivirus metabolism, Hepatitis C blood, Hepatitis C diagnosis, Hyaluronic Acid blood, Liver Cirrhosis blood, Liver Cirrhosis diagnosis
- Abstract
Background : The disease caused by hepatitis C virus (HCV) is asymptomatic, silent, and progressive liver disease. In HCV-infected patients the increase in serum HA is associated with the development of hepatic fibrosis and disease progression. Methods : HCV-RNA detection was performed in all serological samples of blood donors that tested positive using HCV Ultra ELISA. Determination of hyaluronan (HA) was performed in positive HCV samples using ELISA-like fluorometric method. The HA content was compared to HCV viral load, genotype of the virus, liver fibrosis as well as ALT and GGT liver biomarkers. Results : Persistently normal ALT (<40 U/L) and GGT (<50 U/L) serum levels were detected in 75% and 69% of the HCV-Infected blood donors, respectively. Based on ROC analysis, the HA value < 34.2 ng/mL is an optimal cut-off point to exclude HCV viremia (specificity = 91%, NPV = 99%). Applying HA value ≥34.2 ng/mL significant liver fibrosis (≥F2) can be estimated in 46% of the HCV-infected blood donors. HA serum level (≥34.2 ng/mL) associated with a high ALT level (>40 U/mL) can correctly identify HCV infection and probable liver fibrosis (sensitivity = 96% and specificity = 90%) in asymptomatic blood donors. Conclusions : A high level of HA (≥34.2 ng/mL) in association with ALT (≥40 U/L) in serum can provide a good clinical opportunity to detect HCV-infected asymptomatic persons that potentially require a liver biopsy confirmation and antiviral treatment to prevent the development of advanced liver fibrosis or cirrhosis.
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- 2021
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24. Planning and support in the work process of PHC teams in the Northeast: analysis of the PMAQ-AB (3rd cycle).
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Silva GTD, Carvalho FO, Vieira-Meyer APGF, Gomes GMS, Bezerra LMMR, Camelo RV, and Barbosa Filho VC
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- Brazil, Cross-Sectional Studies, Family Health, Humans, Primary Health Care, Quality of Health Care
- Abstract
This paper aims to describe the indicators related to planning and support in the work process reported by the Family Health Teams, from the 3rd cycle of the National Program for Improving Access and Quality of Primary Care (PMAQ-AB) in the Brazilian Northeast. This cross-sectional study employed secondary data from the external evaluation of the 3rd cycle of the PMAQ-AB. Sixteen indicators were used to ascertain the teams' work process actions, and 14,489 family health teams that adhered to the program were evaluated. Among the indicators assessed, we found that the teams held a meeting and planned actions and self-evaluated, monitored, and analyzed health indicators to reorganize the work process, highlighting the determining and conditioning factors. Health surveillance and the Extended Family Health Center (NASF) stand out in the indicators of institutional support and multidisciplinary support for solving complex cases. We identified improvements in the work process of the teams in the Northeast region, but the reality of fragmented and vertical work still requires a change to promote an outlook of shared teamwork, directly influencing the work process.
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- 2021
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25. Multidisciplinary care in Amyotrophic Lateral Sclerosis: a systematic review and meta-analysis.
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de Almeida FEO, do Carmo Santana AK, and de Carvalho FO
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- Humans, Interdisciplinary Studies, Palliative Care, Amyotrophic Lateral Sclerosis therapy, Quality of Life
- Abstract
Multidisciplinary care (MDC) has been the most recommended approach for symptom management in amyotrophic lateral sclerosis (ALS) but there is conflicting evidence about its effectiveness on survival and quality of life (QoL) of ALS patients. We conducted a systematic review to determine the effects of multidisciplinary care compared to general neurological care in survival and quality of life of ALS patients. A comprehensive literature search using Scopus, MEDLINE-PubMed, Cochrane, Web of Science, PEDro, and Science Direct was undertaken. Studies related to multidisciplinary care or general neurological care in ALS patients that assessed survival and quality of life and were published in the period up to and including January 2020 were included. A total of 1192 studies were initially identified, but only 6 were included. All studies that investigated survival showed and advantage of MDC over NC, and this benefit was even greater for bulbar onset patients. A meta-analysis was performed and showed a mean difference of 141.67 (CI 95%, 61.48 to 221.86), indicating that patients who received MDC had longer survival than those who underwent NC (p = 0.0005). Concerning QoL, only one study found better mental health scores related to QoL for patients under MDC. Multidisciplinary care is more effective than general neurology care at improving survival of patients with ALS, but only improves mental health outcomes related to quality of life of these patients.
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- 2021
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26. Mechanism of Action of Limonene in Tumor Cells: A Systematic Review and Meta-Analysis.
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de Vasconcelos C Braz J, de Carvalho FO, de Vasconcelos C Meneses D, Calixto FAF, Santana HSR, Almeida IB, de Aquino LAG, de Souza Araújo AA, and Serafini MR
- Subjects
- Databases, Factual, Limonene, Research Design
- Abstract
Background: Cancer is a complex, multifactorial disease, and a major public health problem, as it is a leading cause of morbidity and mortality worldwide. Although treatments have significantly improved, still more effective drugs are searched. One source for these drugs is natural products (NPs). One NP that has shown anticancer activity is Limonene. However, the mechanisms of limonene's antiproliferative, anticancer and antineoplastic activity are not fully understood., Objective: The objective of this study is to undertake a systematic review and meta-analysis of the literature on this subject., Methods: A comprehensive literature search was performed using the Scopus, MEDLINE-PubMed, Web of Science, and Science Direct databases using the keywords: "limonene", "cancer", "neoplasm", and "tumor". The inclusion criteria were: in vivo and in vitro studies on the use of limonene in cancer published in English, Portuguese and Spanish until December 2019. Review articles, meta-analyses, abstracts, conference papers, editorials/ letters and case reports were excluded., Results: The search identified 3568 articles, of which, 126 were selected for full reading, with 11 papers meeting the review criteria. Six more papers were added from the references of the initial 11 texts, giving a total of 17 papers. There was a high level of agreement in inclusion/exclusion (Kappa index > 80%). The risk of bias in the texts was shown to be high., Conclusion: The meta-analysis suggests that limonene acts mainly on tumor regression induced apoptosis and is a promising natural product for use in the treatment of several types of cancer., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
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- 2021
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27. Improving cognitive and physical function through 12-weeks of resistance training in older adults: Randomized controlled trial.
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Santos PRPD, Cavalcante BR, Vieira AKDS, Guimarães MD, Leandro Da Silva AM, Armstrong ADC, Carvalho RGDS, Carvalho FO, and Souza MF
- Subjects
- Aged, Executive Function physiology, Female, Gait physiology, Humans, Male, Middle Aged, Movement physiology, Muscle Strength physiology, Cognition physiology, Physical Functional Performance, Resistance Training methods
- Abstract
We performed a randomized, controlled trial to analyse the effects of resistance training (RT) on cognitive and physical function among older adults. Fifty participants (mean age 67 years, ~60% woman) were randomly assigned to an RT program or a control group. Participants allocated to RT performed three sets of 10-15RM in nine exercises, three times per week, for 12-weeks. Control group did not perform any exercise. Variables included cognitive (global and executive function) and physical function (gait, mobility and strength) outcomes. At completion of the intervention, RT was shown to have significantly mitigated the drop in selective attention and conflict resolution performance (Stroop test: -494.6; 95%CI: -883.1; -106.1) and promoted a significant improvement in working memory (digit span forward: -0.6; 95%CI: -1.0; -0.1 and forward minus backward: -0.9; 95% CI: -1.6; -0.2) and verbal fluency (animal naming: +1.4, 95%CI 0.3, 2.5). No significant between-group differences were observed for other cognitive outcomes. Regarding physical function, at completion of the intervention, the RT group demonstrated improved fast-pace gait performance (-0.3; 95% CI: -0.6; -0.0) and 1-RM (+21.4 kg; 95%CI: 16.6; 26.2). No significant between-group differences were observed for other mobility-related outcomes. In conclusion, RT improves cognitive and physical function of older adults.
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- 2020
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28. Anti-inflammatory and antioxidant activity of carvacrol in the respiratory system: A systematic review and meta-analysis.
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de Carvalho FO, Silva ÉR, Gomes IA, Santana HSR, do Nascimento Santos D, de Oliveira Souza GP, de Jesus Silva D, Monteiro JCM, de Albuquerque Júnior RLC, de Souza Araújo AA, and Nunes PS
- Subjects
- Animals, Guinea Pigs, Humans, Inflammation drug therapy, Inflammation metabolism, Inflammation prevention & control, Inflammation Mediators metabolism, Malondialdehyde metabolism, Mice, Monoterpenes pharmacology, Randomized Controlled Trials as Topic, Rats, Respiratory System metabolism, Respiratory System pathology, Anti-Inflammatory Agents pharmacology, Antioxidants pharmacology, Cymenes pharmacology, Respiratory System drug effects
- Abstract
Carvacrol is a monoterpene present in the essential oil of a number of plants and has been widely used in traditional medicine because it is considered to have a range of therapeutic effects including in relation to respiratory disease. To conduct a systematic review and meta-analysis to assess the anti-inflammatory and antioxidant activities of carvacrol when used in the treatment of respiratory disorders. A comprehensive literature search using Scopus, MEDLINE-PubMed, Cochrane and Web of Science was undertaken. Papers related to the anti-inflammatory or antioxidant properties of carvacrol in the treatment of an injury in the respiratory system in in vivo studies and published in the period up to and including August 2019. A total of 152 studies were initially identified, with only 17 meeting the inclusion criteria. Five of the studies were performed in humans, and 12 were performed in rodents. Among the 17 studies included in the systematic review, we performed the meta-analysis with nine of the studies with animals. Carvacrol had a positive effect on the reduction of interleukin (IL)-1β, IL-4, IL-8 and malondialdehyde (MDA); however, the analysis indicated that carvacrol had no effect on IL-6 and tumor necrosis factor alpha (TNF-α), probably due to the methodological quality of the studies and their heterogeneity. Current evidence supports the antioxidant and anti-inflammatory effects of carvacrol, but its relationship with the reduction of some inflammatory mediators in animals with lung injury needs further elucidation., (© 2020 John Wiley & Sons, Ltd.)
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- 2020
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29. Quality of life and functional independence in amyotrophic lateral sclerosis: A systematic review.
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Rosa Silva JP, Santiago Júnior JB, Dos Santos EL, de Carvalho FO, de França Costa IMP, and Mendonça DMF
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- Humans, Activities of Daily Living, Amyotrophic Lateral Sclerosis physiopathology, Amyotrophic Lateral Sclerosis rehabilitation, Quality of Life, Severity of Illness Index
- Abstract
Amyotrophic Lateral Sclerosis (ALS) leads to functional capacity decline, generating great impact in quality of life. Quality of life is directly related to physical integrity and functional independence. This systematic review aimed to analyze treatment protocols and their outcomes from clinical trials with focus on ALS rehabilitation that evaluated the effects on quality of life and functional independence from their intervention process. A literature search was conducted through MEDLINE-PubMed, Science Direct, Web of Science and Scopus databases. A total of 3630 articles were identified. Eleven studies met the inclusion criteria. They focused on different aspects of quality of life or functional independence, which are: respiratory care, mental health, communication skills and exercises. Use of bipap and inspiratory muscle training, anxiety and depression, communication devices implementation and exercises safety and tolerability were considered as key points. However, the drastic evolution of the disease is a limiting factor to the perception of quality of life improvement by patients. Further studies should be done to validate the benefits on patients' quality of life., (Copyright © 2019. Published by Elsevier Ltd.)
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- 2020
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30. Dance promotes positive benefits for negative symptoms in autism spectrum disorder (ASD): A systematic review.
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DeJesus BM, Oliveira RC, de Carvalho FO, de Jesus Mari J, Arida RM, and Teixeira-Machado L
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- Humans, Autism Spectrum Disorder therapy, Dancing, Social Participation
- Abstract
Background: Autism spectrum disorder (ASD) is characterized as a neurodevelopmental disorder with stereotyped and repetitive behaviors. Dance practice can elicit esthesia to stimulate the communication process through the notion of the phenomenal body that is recognized in an expressive and symbolic space., Objective: To conduct a systematic review to identify how dance promotes positive benefits for the negative symptoms in ASD., Method: We formulated the research question based on PICO: "What is the influence of dance on negative symptoms in individuals with autism spectrum disorder?". Databases were searched in March 2019 and included PubMed, Science Direct, Scopus, PsycInfo and Web of Science., Results: We identified 9,350 studies of which five were selected for our review (a total of 266 individuals). All included studies showed an influence of dance on negative symptoms, including empathy, emotional expression, body awareness, behavior, and psychological wellbeing that impact on social reciprocity, and consequently the communication process, in ASD., Conclusions: Dance practice may contribute to body awareness and social involvement using techniques that provide mirroring, synchronization, rhythm, and reciprocity in adults with normal to high-functioning ASD., Competing Interests: Declaration of Competing Interest The authors declare that they have no conflict of interest., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
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- 2020
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31. Effects of the solid lipid nanoparticle of carvacrol on rodents with lung injury from smoke inhalation.
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Carvalho FO, Silva ÉR, Nunes PS, Felipe FA, Ramos KPP, Ferreira LAS, Lima VNB, Shanmugam S, Oliveira AS, Guterres SS, Camargo EA, Cravalho Olivera TV, de Albuquerque Júnior RLC, de Lucca Junior W, Quintans-Júnior LJ, and Araújo AAS
- Subjects
- Administration, Inhalation, Animals, Cymenes chemistry, Drug Carriers administration & dosage, Drug Carriers chemistry, Female, Lipids, Lung Injury metabolism, Nanoparticles chemistry, Oxidative Stress drug effects, Oxidative Stress physiology, Random Allocation, Rats, Rats, Wistar, Smoke Inhalation Injury metabolism, Cymenes administration & dosage, Lung Injury drug therapy, Nanoparticles administration & dosage, Smoke Inhalation Injury drug therapy
- Abstract
The aim of this present study was to evaluate the effect of solid lipid nanoparticles (SLN) containing carvacrol over the lung damage of airway smoke inhalation. The study was conducted with 30 rats subjected to smoke inhalation and divided into 5 groups such as, normal control, negative control, oxygen group, SLN alone, and SLN+CARV group. The animals were sacrificed 24 h after the induction of inhalation injury further, the tissues of larynx, trachea, and lungs were collected for the histological, hematological, myeloperoxidase, and malondialdehyde analysis. The obtained results showed that treatment with CARV+SLN minimized the inhalation injury, since it reduced malondialdehyde significantly, when compared to the negative control group and minimized the histological changes which proves the absence of pulmonary emphysema and exudate in laryngeal and tracheal lumen in the CARV+SLN-treated group. Meanwhile, the presence of lesion with chronic characteristics was observed in the negative control and oxygen groups. It is suggested that the SLN containing carvacrol minimized oxidative stress and histological damages generated from smoke inhalation in rodents.
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- 2020
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32. Evaluation instruments for physical therapy using virtual reality in stroke patients: a systematic review.
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Felipe FA, de Carvalho FO, Silva ÉR, Santos NGL, Fontes PA, de Almeida AS, Garção DC, Nunes PS, and de Souza Araújo AA
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- Cognition, Humans, Motivation, Muscle Strength, Postural Balance, Quality of Life, Disability Evaluation, Stroke Rehabilitation methods, Surveys and Questionnaires, Virtual Reality
- Abstract
Background: Physiotherapeutic rehabilitation is essential to improve functional mobility, muscular strength, balance and quality of life of stroke patients, but conventional techniques using repeated physical activities can soon become monotonous. The use of virtual reality (VR) in rehabilitation offers a possible alternative to the traditional methods of promoting improvements in muscle strength and balance. However, there is not yet consensus about which instruments should be used to assess the effectiveness of VR in stroke rehabilitation., Objective: To conduct a systematic review to identify the types of evaluation tools used for different VR interventions to rehabilitate stroke patients, considering balance, strength, function, quality of life, cognition and motivation., Data Sources: A comprehensive literature search using MEDLINE-PubMed, Web of Science, Scopus, Lilacs and IEEE Xplore was undertaken., Study Selection: Studies on stroke patients who had undergone VR therapy and an assessment of its effectiveness using evaluative instruments., Study Appraisal and Synthesis Methods: Data were extracted by a single reviewer using standardised forms, and were checked by a second reviewer. The extracted information included study design, number of participants, type of stroke, items that were evaluated (balance, muscle strength, functional evaluation), console used, number of rehabilitation sessions, results and conclusions., Results: In total, 1836 articles were identified; of these, 29 were included in this review after consideration of the inclusion and exclusion criteria. The selected articles rated one or more of the following factors: balance (n=12), grip strength (with or without devices for direct measurement) (n=8), functionality (n=12) and quality of life (n=12)., Limitations: The full text of one article was not available, despite a request to the authors to send it via email., Conclusion and Implications of Key Findings: The Berg Balance Scale, the Fugl-Meyer Assessment and the Stroke Impact Scale were the instruments used most frequently to assess balance, function and quality of life, respectively, in stroke patients who underwent rehabilitation using VR. Systematic review registration PROSPERO number: 87546., (Copyright © 2019 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.)
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- 2020
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33. Sociodemographic determinants associated with physical activity level of quilombolas in the Brazilian state of Bahia: 2016 survey.
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Rodrigues DN, Mussi RFF, Almeida CB, Nascimento Junior JRA, Moreira SR, and Carvalho FO
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- Adult, Brazil, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Risk Factors, Socioeconomic Factors, Surveys and Questionnaires, Exercise, Sedentary Behavior
- Abstract
Objective to analyze sociodemographic variables associated with insufficient physical activity level in Bahian quilombolas. Methods this was a cross-sectional study with data on sociodemographic characteristics and level of physical activity using a standardized form, administered through interviews with a representative sample of adults living in quilombos in the geographical region of Bahia; crude and adjusted logistic regression was used. Results 850 participants were included whose average age was 45.0+17.0 years; 61.2% were female; prevalence of physical inactivity was 21.9% (95%CI 19.1; 24.7); insufficient physical activity level among adult quilombolas was higher among the elderly (OR 2.12; 95%CI 1.29; 3.49) and individuals who did not work (OR 1.47; 95%CI 1.01; 2, 14). Conclusion being elderly and not working is associated with insufficient physical activity in quilombolas.
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- 2020
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34. Anti-Inflammatory Activity of Limonene in the Prevention and Control of Injuries in the Respiratory System: A Systematic Review.
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Santana HSR, de Carvalho FO, Silva ER, Santos NGL, Shanmugam S, Santos DN, Wisniewski JO, Junior JSC, Nunes PS, Araujo AAS, de Albuquerque Junior RLC, and Dos Santos MRV
- Subjects
- Limonene chemistry, Limonene pharmacology, Meta-Analysis as Topic, Monoterpenes, Oxidative Stress, Terpenes chemistry, Terpenes pharmacology, Anti-Inflammatory Agents pharmacology, Respiratory System
- Abstract
Introduction: The pulmonary inflammatory response results from exposure to injurious factors and is associated with oxidative stress, which intensifies the pathological reaction. In this context, limonene, a monoterpene found in citrus fruits, can be a therapeutic alternative for the treatment of this pathology, as it presents known anti-inflammatory and antioxidant actions., Objective: The purpose of this article is to provide an overview of the anti-inflammatory activity of limonene and its capacity to prevent and control respiratory system injuries., Search Strategy: A comprehensive literature search of the Cochrane, Scopus, MEDLINE-PubMed, Web of Science, and Lilacs databases was performed using the keywords: "limonene", "lung", "pulmonary", "airway", "trachea", "lung injury", "respiratory system", "respiratory tract diseases"., Selection Criteria: Studies on the use of limonene in disorders of the respiratory system, published until August 2019, were included. Those that did not use limonene alone or treated lesions in different systems other than the respiratory system, without targeting its anti-inflammatory action were excluded. In addition, review articles, meta-analyses, abstracts, conference papers, editorials/letters and case reports were also excluded., Results: Of the 561 articles found, 64 were in the Cochrane database, 235 in Scopus, 99 in Web of science, 150 in PubMed and 13 in Lilacs. After completing the systematic steps, 25 articles were selected for full reading, after which 7 papers remained in the review. An article was added after a manual literature search, resulting in a total of 8 papers. There was a high level of agreement on inclusion/exclusion among the researchers who examined the papers (Kappa index > 88%)., Conclusion: Limonene has effective anti-inflammatory activity in both preventing and controlling respiratory system injuries., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
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- 2020
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35. Acceptability of tropical fruit pulps enriched with vegetal/microbial protein sources: viscosity, importance of nutritional information and changes on sensory analysis for different age groups.
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Silva CEF, Abud AKS, Silva ICCD, Andrade NP, Cerqueira RBO, Andrade FP, Carvalho FO, Almeida RMRG, and Souza JEA
- Abstract
The combination of products traditionally consumed with other components with the alleged classification of functional food has become a continuous reality, if not a necessity. This article investigated the supplementation of tropical fruit pulps (acerola- Malpighia emarginata , guava- Psidium guajava , passion fruit- Passiflora edulis and mandarin- Citrus reticulata ), with 5-10% (m/V) on vegetal/microbial protein sources (soy protein, beer yeast and bee pollen). Viscosity and colour analysis were carried out and differences between fruit pulp with no addition and those supplemented were verified, with a specific importance to soy protein, which increased 5-10 times pulps viscosity, while the remaining supplemented formulations, 1.5-3 times. Between the sensory factors (colour, flavour, aroma and appearance), flavour significantly influenced the acceptance of the product ( p < 0.05). The nutritional information provided to tasters, as well as to specific age groups (children, elderly and youngsters/adults), significantly increased the product's acceptance; with values ranging between 70 and 80% in some cases, demonstrating the importance of cognitive response on those factors.
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- 2019
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36. Pharmacological Effects of Carvacrol in In vitro Studies: A Review.
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Silva ER, de Carvalho FO, Teixeira LGB, Santos NGL, Felipe FA, Santana HSR, Shanmugam S, Quintans Júnior LJ, de Souza Araújo AA, and Nunes PS
- Subjects
- Animals, Anti-Infective Agents chemical synthesis, Anti-Infective Agents chemistry, Anti-Inflammatory Agents chemical synthesis, Anti-Inflammatory Agents chemistry, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Antioxidants chemical synthesis, Antioxidants chemistry, Cymenes, Drug Design, Humans, Monoterpenes chemical synthesis, Monoterpenes chemistry, Anti-Infective Agents pharmacology, Anti-Inflammatory Agents pharmacology, Antineoplastic Agents pharmacology, Antioxidants pharmacology, Monoterpenes pharmacology
- Abstract
Carvacrol has a high therapeutic potential, with in vitro studies showing promising results in different cellular models using a variety of methodological designs. Therefore, the objective of this study was to conduct a systematic review to analyze the pharmacological effects of carvacrol in in vitro studies. A comprehensive search of the literature was made using four databases: Science Direct, Scopus, MEDLINE-PubMed, and Web of Science using different combinations of the following keywords: carvacrol, drug therapy, therapeutic uses, in vitro study. The search of the databases was for studies conducted in the period up to and including September 2016. A total of 3,269 studies were initially identified, with only 31 meeting the inclusion criteria. The included studies contained a variety of in vitro models able to determine the properties of Carvacrol. The following properties of Carvacrol were identified: antimicrobial (7 studies), bactericidal (4), bactericidal and antifungal (1), antiinflammatory (4), anticancer (4), mutagenic (4), antioxidant (3), antifungal (3), antidepressant (1), as a modulator of nerve impulses (1) and an immunological modulator (1). The In vitro studies with Carvacrol included in this review showed a diversity of models and confirmed the therapeutic potential of this product in relation to several diseases., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Published
- 2018
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37. The role of interleukins in vitiligo: a systematic review.
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Gomes IA, de Carvalho FO, de Menezes AF, Almeida FM, Shanmugam S, de Souza Siqueira Quintans J, Quintans-Júnior LJ, de Moura TR, Oliveira PD, and de Souza Araújo AA
- Subjects
- Humans, Interleukin-10 metabolism, Interleukin-17 metabolism, Interleukin-2 metabolism, Interleukin-33 metabolism, Interleukin-4 metabolism, Interleukin-6 metabolism, Interleukins metabolism, Vitiligo metabolism
- Abstract
Vitiligo is a disorder of the skin that causes depigmentation and asymptomatic macules whose exact cause is still unclear. Although its aetiology is not fully elucidated, the main theory of its pathomechanism is that it is associated with the autoimmune process. There is few summarized information about the role of inflammatory mediators, as interleukins, in vitiligo, so our aim was to present a systematic review of the role of interleukins in vitiligo, focusing on interleukins. In this review, we included all studies assessing interleukin levels in vitiligo patients conducted up to June 2017. Quality assessment of these studies was performed using the Newcastle-Ottawa Scale (NOS). The interleukins mainly involved were IL-2, IL-4, IL-6, IL-10 and IL-17. The studies highlight the crucial role of IL-17 in the onset and progression of the disease, and its synergistic action with IL-2, IL-6 and IL-33. Dysregulated levels of the interleukins were also correlated with the stage of disease, the affected skin surface area, and indicated as the main factor for lymphocyte infiltration found in depigmented regions. These findings illustrate the growing need for new therapies targeting vitiligo and further research into the role of interleukins as an area of particular interest., (© 2018 European Academy of Dermatology and Venereology.)
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- 2018
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38. Antiplatelet agents in perioperative noncardiac surgeries: to maintain or to suspend?
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Borges JMDM, de Carvalho FO, Gomes IA, Rosa MB, and Sousa ACS
- Abstract
Background: When prescribing antiplatelet agents, physicians face the challenge of protecting patients from thromboembolic events without inducing bleeding damage. However, especially in the perioperative period, the use of these medications requires a carefully balanced assessment of their risks and benefits., Objective: To conduct a systematic review to check whether the antiplatelet agent is to be maintained or suspended in the perioperative period of noncardiac surgeries., Search Strategy: A comprehensive literature search using Science Direct, Scopus, MEDLINE-PubMed, and Web of Science was undertaken., Selection Criteria: Clinical trials of noncardiac surgeries with patients taking regular anti-platelet therapy, published between 2013 and 2018., Results: A total of 1,302 studies were initially identified, with only four meeting the inclusion criteria. The selected studies were conducted in different countries such as, including India (2), Serbia (1), and the USA (1). The age group was similar in all studies, from 61 to 75 years. The most frequent surgery was related to tooth extraction and transurethral resection of bladder cancer. There was a group of patients who used single antiplatelet agents and groups who used single therapy and double therapy. Acetylsalicylic acid was the common drug in all studies., Conclusion: It was concluded that the clinical trials were classified as good quality and that it was not necessary to suspend antiplatelet therapy prior to surgical procedures such as dental extraction and transurethral resection of bladder cancer. It should be noted that it is necessary to jointly evaluate the type of antiplatelet agent, the thrombotic risk of the patient, and the hemorrhagic risk of the surgical procedure., Competing Interests: Disclosure The authors report no conflicts of interest in this work.
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- 2018
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39. Restless Legs Syndrome in Dialysis Patients: Does the Dialysis Modality Influence Its Occurrence and Severity?
- Author
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de Menezes AF, Motta DRMS, de Carvalho FO, Santana-Santos E, de Andrade Júnior MP, Figueirôa MF, Farias MIT, and Bastos KA
- Abstract
Background: Restless legs syndrome (RLS) is more prevalent in chronic kidney patients than in the general population, but it is often diagnosed late and its predictors are unknown., Purpose: To diagnose RLS in a group of chronic kidney patients on dialysis, determine its frequency and severity, compare the prevalence and severity of the condition among dialytic modalities, and identify possible predictive factors in this population., Methods: An observational and cross-sectional study with 326 patients who had been on dialysis for more than 3 months, 241 on hemodialysis (HD) and 85 on automatic peritoneal dialysis (APD), using the criteria established by the International Study Group on RLS for the diagnosis and the RLS Rating Scale to determine its severity., Results: RLS was diagnosed in 19.3% of the patients, 52.4% with severe or very severe forms. Patients with and without RLS did not differ in clinical and demographic characteristics and dialytic modality; however, patients on APD presented higher RLS severity compared to the HD group., Conclusions: RLS is frequent in dialysis patients and occurs predominantly in its most severe forms; the dialytic modality seems to have no influence on its occurrence; however, it is more severe in patients on APD.
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- 2018
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40. A Middleware with Comprehensive Quality of Context Support for the Internet of Things Applications.
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Gomes BTP, Muniz LCM, da Silva E Silva FJ, Dos Santos DV, Lopes RF, Coutinho LR, Carvalho FO, and Endler M
- Abstract
Context aware systems are able to adapt their behavior according to the environment in which the user is. They can be integrated into an Internet of Things (IoT) infrastructure, allowing a better perception of the user's physical environment by collecting context data from sensors embedded in devices known as smart objects. An IoT extension called the Internet of Mobile Things (IoMT) suggests new scenarios in which smart objects and IoT gateways can move autonomously or be moved easily. In a comprehensive view, Quality of Context (QoC) is a term that can express quality requirements of context aware applications. These requirements can be those related to the quality of information provided by the sensors (e.g., accuracy, resolution, age, validity time) or those referring to the quality of the data distribution service (e.g, reliability, delay, delivery time). Some functionalities of context aware applications and/or decision-making processes of these applications and their users depend on the level of quality of context available, which tend to vary over time for various reasons. Reviewing the literature, it is possible to verify that the quality of context support provided by IoT-oriented middleware systems still has limitations in relation to at least four relevant aspects: (i) quality of context provisioning; (ii) quality of context monitoring; (iii) support for heterogeneous device and technology management; (iv) support for reliable data delivery in mobility scenarios. This paper presents two main contributions: (i) a state-of-the-art survey specifically aimed at analyzing the middleware with quality of context support and; (ii) a new middleware with comprehensive quality of context support for Internet of Things Applications. The proposed middleware was evaluated and the results are presented and discussed in this article, which also shows a case study involving the development of a mobile remote patient monitoring application that was developed using the proposed middleware. This case study highlights how middleware components were used to meet the quality of context requirements of the application. In addition, the proposed middleware was compared to other solutions in the literature., Competing Interests: The authors declare no conflict of interest.
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- 2017
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41. Creatine supplementation elicits greater muscle hypertrophy in upper than lower limbs and trunk in resistance-trained men.
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Nunes JP, Ribeiro AS, Schoenfeld BJ, Tomeleri CM, Avelar A, Trindade MC, Nabuco HC, Cavalcante EF, Junior PS, Fernandes RR, Carvalho FO, and Cyrino ES
- Subjects
- Absorptiometry, Photon, Adolescent, Adult, Athletic Performance, Creatine adverse effects, Double-Blind Method, Humans, Lower Extremity, Male, Muscle, Skeletal diagnostic imaging, Organ Specificity, Performance-Enhancing Substances adverse effects, Reproducibility of Results, Torso, Upper Extremity, Young Adult, Creatine administration & dosage, Dietary Supplements adverse effects, Muscle Development, Muscle, Skeletal growth & development, Performance-Enhancing Substances administration & dosage, Resistance Training
- Abstract
Background: Creatine (Cr) supplementation associated with resistance training produces greater muscular strength improvements in the upper compared with the lower body; however, no study has investigated if such region-specific results are seen with gains in muscle mass., Aim: We aimed to evaluate the effect of Cr supplementation in combination with resistance training on lean soft tissue changes in the upper and lower limbs and trunk in resistance-trained young adult men., Methods: In a randomized, double-blind and placebo-controlled design, 43 resistance-trained men (22.7 ± 3.0 years, 72.9 ± 8.7 kg, 177.9 ± 5.7 cm, 23.0 ± 2.5 kg/m
2 ) received either creatine (Cr, n = 22) or placebo (PLA, n = 21) over an 8-week study period. The supplementation protocol included a loading phase (7 days, four doses of 0.3 g/kg per day) and a maintenance phase (7 weeks, single dose of 0.03 g/kg per day). During the same period, subjects performed resistance training four times per week using the following two-way split routine: Monday and Thursday = pectoral, shoulders, triceps, and abdomen, Tuesday and Friday = back, biceps, thighs, and calves. Lean soft tissue of the upper limbs (ULLST), lower limbs (LLLST), and trunk (TLST) was assessed by dual-energy X-ray absorptiometry before and after the intervention., Results: Both groups showed significant ( p < 0.001) improvements in ULLST, LLLST, TLST, and the Cr group achieved greater ( p < 0.001) increases in these outcomes compared with PLA. For the Cr group, improvements in ULLST (7.1 ± 2.9%) were higher than those observed in LLLST (3.2 ± 2.1%) and TLST (2.1 ± 2.2%). Otherwise, for PLA group there was no significant difference in the magnitude of segmental muscle hypertrophy (ULLST = 1.6 ± 3.0%; LLLST = 0.7 ± 2.8%; TLST = 0.7 ± 2.8%)., Conclusion: Our results suggest that Cr supplementation can positively augment muscle hypertrophy in resistance-trained young adult men, particularly in the upper limbs.- Published
- 2017
- Full Text
- View/download PDF
42. Natural and synthetic products used for the treatment of smoke inhalation: a patent review.
- Author
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De Carvalho FO, Silva ÉR, Felipe FA, Teixeira LGB, Zago LBS, Nunes PS, Shanmugam S, Serafini MR, and Araújo AAS
- Subjects
- Animals, Burns pathology, Humans, Patents as Topic, Respiratory System physiopathology, Smoke Inhalation Injury physiopathology, Biological Products therapeutic use, Drug Design, Smoke Inhalation Injury drug therapy
- Abstract
Introduction: Inhalation injury is the leading cause of death in burn patients and is usually caused by the uninhibited absorption of smoke, which has an extremely toxic effect on the respiratory system. The physiopathology of inhalation injury covers multiple factors and the injured respiratory system may present deterioration in a few hours. Areas covered: In this present review, we analyzed patents based on both natural and synthetic products developed for the treatment of smoke inhalation. We found 14 patents in Espacenet, 25 in WIPO and none in the USPTO data search. Expert opinion: Several previous reports on treatments used for smoke inhalation are discussed. Although there are a number of research based products for this injury, there has been no review of the patents dealing with treatments for smoke inhalation. The development of novel natural or synthetic products are discussed in detail in the review.
- Published
- 2017
- Full Text
- View/download PDF
43. Creation of a contusion injury method for skeletal muscle in rats with differing impacts.
- Author
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Dantas MGB, Damasceno CMD, Barros VRP, Menezes ES, Fontoura HS, Lima RS, Carvalho FO, and Almeida JRGDS
- Subjects
- Animals, Contusions etiology, Equipment Design instrumentation, Equipment Design methods, Female, Inflammation pathology, Muscle, Skeletal pathology, Rats, Wistar, Contusions pathology, Disease Models, Animal, Muscle, Skeletal injuries
- Abstract
Purpose:: To realize a morphological examination of the musculoskeletal tissue, assessing the effect of a contusion method for the production in rat gastrocnemius, comparing the inflammatory responses generated by different impacts., Methods:: For the analysis of a contusion method, twelve female Wistar rats were distributed into four groups. The lesion was generated by 324 g of mass that was dropped from different predetermined heights for each group (30, 45, 60 and 70 cm)., Results:: In the analysis of musculoskeletal tissue, the response to injury varied according to the mass of the height drop onto the muscle. Only the group that was injured from 70 cm responded with uniform and severe inflammation, whereas the groups 30, 45 and 60 cm showed inflammation in some regions of the tissue with mild and moderate infiltrates., Conclusion:: The method with the 324-gram mass dropped from a 70-cm height onto the gastrocnemius muscle of rats seems to be the most suitable for the production of muscle injury in these animals after 72 hours, showing an important inflammatory infiltrate.
- Published
- 2017
- Full Text
- View/download PDF
44. Synthetic drugs for the treatment of vitiligo: a patent review (2010-2015).
- Author
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de Menezes AF, Shanmugam S, Gomes IA, de Carvalho FO, Quintans-Júnior LJ, Gurgel RQ, de Santana Silva B, Serafini MR, and Araújo AAS
- Abstract
Introduction: Vitiligo is one of the most important acquired depigmentation disorders, with an average worldwide prevalence of 0.5-2.0%. The exact etiology of vitiligo is not fully understood, but the principle theories focus on the mechanism responsible for the destruction of melanocytes, which is proposed to be autoimmune, neurogenic, or self-destructive. There is no cure for vitiligo and the results of current treatments vary between individuals, being unsatisfactory in most cases. Despite being a cosmetic disease, the disorder can be psychologically devastating and stigmatizing. Areas covered: In this review, the authors summarize new synthetic drugs for the treatment of vitiligo developed between 2010 and 2015, which include MC1 R agonists and peptides, as well as considering new approaches and strategies using existing drugs. Expert opinion: In conclusion, we found significant advancement in this field of research, demonstrating the growing interest of academic and industrial groups in developing successful products for the treatment of vitiligo. New therapeutic options could contribute to improving the quality of life of patients and advance the search for a truly effective treatment of vitiligo.
- Published
- 2016
- Full Text
- View/download PDF
45. Inflammatory Mediators and Oxidative Stress in Animals Subjected to Smoke Inhalation: A Systematic Review.
- Author
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de Carvalho FO, Felipe FA, de Melo Costa AC, Teixeira LG, Silva ÉR, Nunes PS, Shanmugam S, de Lucca Junior W, Quintans JS, and de Souza Araújo AA
- Subjects
- Animals, Biomarkers metabolism, Interleukin-1beta metabolism, Interleukin-6 metabolism, Interleukin-8 metabolism, Malondialdehyde metabolism, NF-kappa B metabolism, Peroxidase metabolism, Tumor Necrosis Factor-alpha metabolism, Cytokines metabolism, Inflammation metabolism, Inflammation Mediators metabolism, Oxidative Stress, Smoke Inhalation Injury metabolism
- Abstract
Background: The inhalation injury is usually initiated by uninhibited absorption of smoke, favoring the release of cytokines and other lipid mediators from inflammatory cells in lung airways and parenchyma., Objectives: To systematically review, examine, and synthesize the main inflammatory mediators analyzed in published studies in animals subjected to smoke inhalation, as well as oxidative stress., Search Strategy: A comprehensive literature search was conducted through MEDLINE-PubMed, Web of Science, and Scopus., Selection Criteria: Studies with animals subjected to lung damage from smoke inhalation that evaluated the presence and the action of inflammatory mediators and oxidative stress., Results: A total of 1332 studies were initially identified, with only 31 meeting the inclusion criteria. The inflammatory mediators and oxidative stress markers studied and presented in the articles described herein were varied; however, the most cited ones were tumor necrosis factor-alpha (6), IL-8 and IL-6 (both studied in five articles), IL-1β and nuclear factor kappa β (both studied in 4 articles), malondialdehyde (11 studies), and myeloperoxidase (7). It is worth noting that most studies evaluated more than one inflammatory mediator and oxidative stress marker., Conclusion: Based on this review, we could observe that the main inflammatory mediators and oxidative stress markers analyzed were TNF-α, IL-8, IL-6, IL-1β, nuclear factor kappa β, MDA, and MPO. However, it is necessary to increase the rigor of study design and data, in order to have studies that are more homogeneous and with appropriate methodological quality.
- Published
- 2016
- Full Text
- View/download PDF
46. Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol.
- Author
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Dantas MG, Reis SA, Damasceno CM, Rolim LA, Rolim-Neto PJ, Carvalho FO, Quintans-Junior LJ, and Almeida JR
- Subjects
- Animals, Chemistry, Pharmaceutical, Drug Stability, Hydrogen-Ion Concentration, Mice, Viscosity, Camphanes chemistry, Gels, Monoterpenes chemistry
- Abstract
Borneol is a bicyclic monoterpenoid alcohol commonly used in traditional Chinese and Indian medicine. It is extracted from the essential oil of various medicinal plants. It has antibacterial, analgesic, and anti-inflammatory action proven in studies that used oral and intraperitoneal applications of this monoterpene in mice. The current study was designed to develop a topical gel formulation containing the monoterpene borneol using carbopol as gel base and to evaluate its stability. The prepared formulation was subjected to physical characterization and physical-chemistry assessment. The gel was prepared from carbopol and 5% of borneol. The prepared gel was subjected to pharmacotechnical tests such as its pH, viscosity, conductivity, spreadability, centrifugation, and accelerated stability with freezing-thaw cycle. The borneol was successfully incorporated into the carbopol formulation. Borneol gel (BG5) showed good stability after eight months of its development and after 12 days in the freeze-thaw cycle, not showing statistical difference in pH value, conductivity, and viscosity before and after test. Furthermore, the formulation showed a good spreadability. Therefore, it was concluded that the formulation could be very promising alternative for the topical or transdermal treatment of skin diseases.
- Published
- 2016
- Full Text
- View/download PDF
47. Products with Natural Components to Heal Dermal Burns: A Patent Review.
- Author
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de Melo Costa AC, Pereira Ramos KP, Serafini MR, de Carvalho FO, Teixeira LG, Garcao DC, Shanmugam S, de Souza Araujo AA, and Nunes PS
- Subjects
- Humans, Patents as Topic, Biological Products therapeutic use, Burns drug therapy, Wound Healing drug effects
- Abstract
Background: Burns are a global public health problem, and non-fatal burn injuries are a leading cause of morbidity. The scale of the problem has led researchers to seek to develop new prod- ucts (both synthetic and natural) for use in the treatment of burn lesions., Objective: The aim of this study was to examine all patents in databases between 2010 and 2015 related to natural prod- ucts for the treatment of burn-related wounds that targeted tissue repair and healing., Method: The search term "burn" and the code A61K36/00 (plant and other natural derivatives used in medicinal prepara- tions) from the international classification of patents were used to identify treatments., Results: The search was performed in the WIPO, ESPACENET and USPTO databases. The highest number of patent ap- plications was found in the WIPO data base (617), followed by ESPACENET(23) and USPTO(6). The USA and China were the countries with the most patent applications, and 2008 was the year that had the highest number of applications. Patent applications written in Spanish, English and Portuguese and that were published between 2010 and 2015 were se- lected. 559 patent applications in other languages, and 63 that did not result in the creation of new products between 2010 and 2015 were excluded and the remaining 13 patents application were selected for full reading of the text., Conclusion: Through this study we were able to identify and summarize the new active natural compounds that can be used in the treatment of burns, both in terms of tissue recovery and analgesia.
- Published
- 2015
- Full Text
- View/download PDF
48. Traditional games resulted in post-exercise hypotension and a lower cardiovascular response to the cold pressor test in healthy children.
- Author
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Rauber SB, Boullosa DA, Carvalho FO, de Moraes JF, de Sousa IR, Simões HG, and Campbell CS
- Abstract
The present study aimed to verify if blood pressure (BP) reactivity could be reduced through a previous single session of active playing when compared to sedentary leisure. Sixteen pre-pubertal healthy children participated in this study. After familiarization with procedures and anthropometric evaluation, participants performed three sessions in randomized order: (1) 30 min of traditional Brazilian games (PLAY); (2) 30 min of video game playing (DDR); and (3) 30 min of watching TV (TV). Each session lasted 80 min, being 10 min of rest; 30 min of intervention activity; and 40 min of recovery. After recovery, the Cold Pressor Test (CPT) was used for the assessment of acute cardiovascular reactivity. BP was recorded at 30 s and 1 min during the CPT. Analysis of variance showed post-exercise hypotension (PEH) only after PLAY, and that systolic and diastolic BP were significantly increased in all conditions during CPT. However, the magnitude of the CPT-induced BP response was significantly less in PLAY compared to DDR and TV. The PEH observed during recovery and the reduced BP response to CPT following playing traditional games may be due its higher cardiovascular and metabolic demand as was indicated by the increased heart rate, oxygen consumption, and BP. It was concluded that BP reactivity to stress may be reduced through a previous single session of traditional games and that PEH was recorded only after this exercise form. This benefit indicates a potential role of playing strategies for cardiovascular health in childhood.
- Published
- 2014
- Full Text
- View/download PDF
49. Laparoscopic assisted ventriculoperitoneal shunt revisions as an option for pediatric patients with previous intraabdominal complications.
- Author
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Carvalho FO, Bellas AR, Guimarães L, and Salomão JF
- Subjects
- Adolescent, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Hydrocephalus complications, Male, Peritonitis surgery, Reproducibility of Results, Retreatment, Retrospective Studies, Risk Factors, Treatment Outcome, Abdominal Cavity surgery, Laparoscopy methods, Ventriculoperitoneal Shunt methods, Video-Assisted Surgery methods
- Abstract
Unlabelled: Multiple shunt failure is a challenge in pediatric neurosurgery practice and one of the most feared complications of hydrocephalus., Objective: To demonstrate that laparoscopic procedures for distal ventriculoperitoneal shunt failure may be an effective option for patients who underwent multiple revisions due to repetitive manipulation of the peritoneal cavity, abdominal pseudocyst, peritonitis or other situations leading to a "non reliable" peritoneum., Method: From March 2012 to February 2013, the authors reviewed retrospectively the charts of six patients born and followed up at our institution, which presented with previous intra-peritoneal complications and underwent ventriculoperitoneal shunt revision assisted by video laparoscopy., Results: After a mean follow-up period of nine months, all patients are well and no further shunt failure was identified so far., Conclusion: Laparoscopy assisted shunt revision in children may be, in selected cases, an effective option for patients with multiple peritoneal complications due to ventriculo-peritoneal shunting.
- Published
- 2014
- Full Text
- View/download PDF
50. A new strategy to identify rare blood donors: single polymerase chain reaction multiplex SNaPshot reaction for detection of 16 blood group alleles.
- Author
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Latini FR, Gazito D, Arnoni CP, Muniz JG, de Medeiros Person R, Carvalho FO, Baleotti W Jr, Castilho L, and Barreto JA
- Subjects
- Alleles, Blood Group Antigens analysis, Blood Grouping and Crossmatching economics, Brazil, Cost-Benefit Analysis, Costs and Cost Analysis, DNA Primers, Donor Selection economics, High-Throughput Nucleotide Sequencing economics, Humans, Polymerase Chain Reaction economics, Polymorphism, Restriction Fragment Length, Blood Donors, Blood Group Antigens genetics, Blood Grouping and Crossmatching methods, Donor Selection methods, Polymerase Chain Reaction methods, Polymorphism, Single Nucleotide
- Abstract
Background: As an alternative to phenotyping, large-scale DNA-based assays, which are feasible for high-throughput donor red blood cell typing, were developed for determination of blood group polymorphisms. However, high-throughput genotyping platforms based on these technologies are still expensive and the inclusion of single nucleotide polymorphisms and analysis of the alleles depend on the manufacturer's determination. To overcome this limitation and in order to develop an assay to enable the screening of rare donors, we developed a SNaPshot assay for analysis of nine single nucleotide polymorphisms related to antigens that are difficult to assess using conventional serology., Materials and Methods: The single polymerase chain reaction multiplex SNaPshot reaction was optimized to identify nine single nucleotide polymorphisms determining 16 alleles: KEL*3/KEL*4, KEL*6/KEL*7, DI*1/DI*2, DI*3/DI*4, YT*1/YT*2, CO*1/CO*2, DO*1/DO*2, DO*4, DO*5. We designed a single multiplex PCR with primers encompassing the blood group single nucleotide polymorphisms and performed an internal reaction with probe primers able to discriminate the alleles after fragment analysis. The SNaPshot assay was validated with 140 known alleles previously determined by PCR restriction fragment length polymorphism., Results: We were able to simultaneous detect nine single nucleotide polymorphisms defining 16 blood group alleles on an assay based on a multiplex PCR combined with a single base extension using genomic DNA., Discussion: This study demonstrates a robust genotyping strategy for conducting rare donor screening which can be applied in blood centers and could be an important tool for identifying antigen-negative donors and, therefore, for providing rare blood.
- Published
- 2014
- Full Text
- View/download PDF
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